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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:N-hydroxy-4-aminobiphenyl
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Accession:CHEBI:16580 term browser browse the term
Definition:A N-substituted amine that is 4-aminobiphenyl substituted by a hydroxy group at the nitrogen atom.
Synonyms:related_synonym: 4-biphenylhydroxylamine;   4-hydroxyaminobiphenyl;   4-hydroxylaminobiphenyl;   N-1,1'-biphenyl-4-ylhydroxylamine;   N-4-biphenylylhydroxylamine;   N-hydroxy-[1,1'-biphenyl]-4-amine
 alt_id: CHEBI:12601;   CHEBI:21736;   CHEBI:7296
 xref: CAS:6810-26-0
 xref_mesh: MESH:C014593
 xref: Reaxys:2639597;   kegg.compound:C03622;   pubmed:1600616;   pubmed:16970317;   pubmed:24881456;   pubmed:647655
 chemrof_formula: C12H11NO
 chemrof_inchi: InChI=1S/C12H11NO/c14-13-12-8-6-11(7-9-12)10-4-2-1-3-5-10/h1-9,13-14H
 chemrof_inchikey: MYVLYOJYVMLSFA-UHFFFAOYSA-N
 chemrof_smiles: ONc1ccc(-c2ccccc2)cc1
 cyclic_relationship: has_functional_parent CHEBI:1784


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N-hydroxy-4-aminobiphenyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hras HRas proto-oncogene, GTPase multiple interactions ISO [N-hydroxy-4-aminobiphenyl co-treated with Copper] results in increased mutagenesis of HRAS gene CTD PMID:11275476 NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:205,725,975...205,729,590 		JBrowse link
G Nat2 N-acetyltransferase 2 increases metabolic processing ISO NAT2 protein results in increased metabolism of N-hydroxy-4-aminobiphenyl CTD PMID:16857729 NCBI chr16:26,974,874...27,005,191
Ensembl chr16:26,974,601...26,976,304 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions
increases sulfation 		ISO N-hydroxy-4-aminobiphenyl inhibits the reaction [SULT1A1 protein results in increased sulfation of Estradiol]
SULT1A1 protein results in increased sulfation of N-hydroxy-4-aminobiphenyl 		CTD PMID:17433394 NCBI chr 1:190,702,592...190,706,112
Ensembl chr 1:190,702,592...190,706,131 		JBrowse link
G Sult1c2a sulfotransferase family 1C member 2A increases sulfation ISO SULT1C2 protein results in increased sulfation of N-hydroxy-4-aminobiphenyl CTD PMID:17433394 NCBI chr 9:7,075,873...7,103,316
Ensembl chr 9:7,066,905...7,244,132 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [N-hydroxy-4-aminobiphenyl co-treated with Copper] results in increased mutagenesis of TP53 gene CTD PMID:11275476 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      biological role 20831
        aetiopathogenetic role 19572
          carcinogenic agent 18900
            N-hydroxy-4-aminobiphenyl 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            heteroorganic entity 20201
                              organonitrogen compound 19311
                                organic amino compound 17164
                                  amine 6497
                                    primary amine 2768
                                      primary arylamine 393
                                        aminobiphenyl 82
                                          N-hydroxy-4-aminobiphenyl 5
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