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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tetrahydropalmatine
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Accession:CHEBI:16563 term browser browse the term
Definition:A berberine alkaloid obtained by formal addition of two molecules of hydrogen to the pyridine ring of palmatine.
Synonyms:exact_synonym: (13aS)-2,3,9,10-tetramethoxy-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline
 related_synonym: (S)-Tetrahydropalmatine;   2,3,9,10-tetramethoxy-13aalpha-berbine;   Formula=C21H25NO4;   InChI=1S/C21H25NO4/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4/h5-6,10-11,17H,7-9,12H2,1-4H3/t17-/m0/s1;   InChIKey=AEQDJSLRWYMAQI-KRWDZBQOSA-N;   L-tetrahydropalmatine;   SMILES=[H][C@@]12Cc3ccc(OC)c(OC)c3CN1CCc1cc(OC)c(OC)cc21
 alt_id: CHEBI:15223;   CHEBI:26917;   CHEBI:9486
 xref: CAS:483-14-7;   KEGG:C02890;   KNApSAcK:C00025252
 xref_mesh: MESH:C014215
 xref: MetaCyc:TETRAHYDROPALMATINE;   PMID:10680579;   PMID:11488467;   PMID:12709895;   PMID:17260290;   PMID:19544352;   PMID:19927376;   PMID:20083181;   PMID:20109541;   PMID:20234973;   PMID:20349723;   PMID:20828314;   PMID:20884991;   PMID:21196089;   PMID:21319371;   PMID:21493954;   PMID:21633914;   PMID:21678521;   PMID:21733652;   Reaxys:96288;   Wikipedia:Tetrahydropalmatine


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tetrahydropalmatine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcf1 ATP binding cassette subfamily F member 1 decreases expression ISO tetrahydropalmatine results in decreased expression of ABCF1 protein CTD PMID:20109541 NCBI chr20:2,802,519...2,815,433
Ensembl chr20:2,802,488...2,815,433 		JBrowse link
G Acbd3 acyl-CoA binding domain containing 3 increases expression ISO tetrahydropalmatine results in increased expression of ACBD3 protein CTD PMID:20109541 NCBI chr13:92,455,813...92,484,556
Ensembl chr13:92,455,655...92,483,380 		JBrowse link
G Acot9 acyl-CoA thioesterase 9 decreases expression ISO tetrahydropalmatine results in decreased expression of ACOT9 protein CTD PMID:20109541 NCBI chr  X:40,073,197...40,123,573
Ensembl chr  X:40,064,810...40,123,559 		JBrowse link
G Aldh5a1 aldehyde dehydrogenase 5 family, member A1 increases expression ISO tetrahydropalmatine results in increased expression of ALDH5A1 protein CTD PMID:20109541 NCBI chr17:40,132,339...40,158,677
Ensembl chr17:40,130,883...40,158,677 		JBrowse link
G Ap2a1 adaptor related protein complex 2 subunit alpha 1 increases expression ISO tetrahydropalmatine results in increased expression of AP2A1 protein CTD PMID:20109541 NCBI chr 1:95,384,306...95,414,170
Ensembl chr 1:95,384,309...95,414,147 		JBrowse link
G Ar androgen receptor multiple interactions EXP tetrahydropalmatine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of AR mRNA] CTD PMID:37606869 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Arhgap1 Rho GTPase activating protein 1 decreases expression ISO tetrahydropalmatine results in decreased expression of ARHGAP1 protein CTD PMID:20109541 NCBI chr 3:77,621,377...77,643,400
Ensembl chr 3:77,620,655...77,643,396 		JBrowse link
G Arih1 ariadne RBR E3 ubiquitin protein ligase 1 decreases expression ISO tetrahydropalmatine results in decreased expression of ARIH1 protein CTD PMID:20109541 NCBI chr 8:59,777,378...59,879,762
Ensembl chr 8:59,777,379...59,880,245 		JBrowse link
G Arpc3 actin related protein 2/3 complex, subunit 3 decreases expression ISO tetrahydropalmatine results in decreased expression of ARPC3 protein CTD PMID:20109541 NCBI chr12:34,172,780...34,186,651
Ensembl chr12:34,172,780...34,186,651 		JBrowse link
G Arpp19 cAMP-regulated phosphoprotein 19 decreases expression ISO tetrahydropalmatine results in decreased expression of ARPP19 protein CTD PMID:20109541 NCBI chr 8:75,779,640...75,802,474
Ensembl chr 8:75,779,523...75,802,452
Ensembl chr 8:75,779,523...75,802,452 		JBrowse link
G Atad3a ATPase family, AAA domain containing 3A increases expression ISO tetrahydropalmatine results in increased expression of ATAD3A protein CTD PMID:20109541 NCBI chr 5:166,350,302...166,370,492
Ensembl chr 5:166,350,304...166,370,482 		JBrowse link
G Atp2b1 ATPase plasma membrane Ca2+ transporting 1 decreases expression ISO tetrahydropalmatine results in decreased expression of ATP2B1 protein CTD PMID:20109541 NCBI chr 7:33,735,595...33,845,226
Ensembl chr 7:33,735,871...33,843,295 		JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO tetrahydropalmatine results in increased expression of BAD protein CTD PMID:20109541 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO tetrahydropalmatine results in increased expression of BAX protein CTD PMID:20109541 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member decreases expression ISO tetrahydropalmatine results in decreased expression of BCAR1 protein CTD PMID:20109541 NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO tetrahydropalmatine results in decreased expression of BCL2 protein CTD PMID:20109541 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bzw1 basic leucine zipper and W2 domains 1 decreases expression ISO tetrahydropalmatine results in decreased expression of BZW1 protein CTD PMID:20109541 NCBI chr 9:59,930,672...59,944,468
Ensembl chr 9:59,930,744...59,944,430 		JBrowse link
G Cald1 caldesmon 1 decreases expression
increases expression		 ISO tetrahydropalmatine results in decreased expression of CALD1 protein
tetrahydropalmatine results in increased expression of CALD1 protein		 CTD PMID:20109541 NCBI chr 4:63,265,781...63,446,938
Ensembl chr 4:63,265,942...63,446,932 		JBrowse link
G Calu calumenin decreases expression ISO tetrahydropalmatine results in decreased expression of CALU protein CTD PMID:20109541 NCBI chr 4:57,949,086...57,976,589
Ensembl chr 4:57,948,997...57,976,593 		JBrowse link
G Casp3 caspase 3 increases cleavage ISO tetrahydropalmatine results in increased cleavage of CASP3 protein CTD PMID:20109541 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cavin3 caveolae associated protein 3 decreases expression ISO tetrahydropalmatine results in decreased expression of CAVIN3 protein CTD PMID:20109541 NCBI chr 1:159,826,549...159,828,138
Ensembl chr 1:159,826,549...159,828,161 		JBrowse link
G Cc2d1b coiled-coil and C2 domain containing 1B decreases expression ISO tetrahydropalmatine results in decreased expression of CC2D1B protein CTD PMID:20109541 NCBI chr 5:123,353,289...123,367,343
Ensembl chr 5:123,353,292...123,367,318 		JBrowse link
G Ckap5 cytoskeleton associated protein 5 decreases expression ISO tetrahydropalmatine results in decreased expression of CKAP5 protein CTD PMID:20109541 NCBI chr 3:77,491,195...77,593,300
Ensembl chr 3:77,491,276...77,593,264 		JBrowse link
G Ckb creatine kinase B decreases secretion ISO tetrahydropalmatine results in decreased secretion of CKB protein CTD PMID:37606869 NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315 		JBrowse link
G Clip1 CAP-GLY domain containing linker protein 1 decreases expression ISO tetrahydropalmatine results in decreased expression of CLIP1 protein CTD PMID:20109541 NCBI chr12:32,910,932...33,017,891
Ensembl chr12:32,910,977...33,017,884 		JBrowse link
G Coa6 cytochrome c oxidase assembly factor 6 decreases expression ISO tetrahydropalmatine results in decreased expression of COA6 protein CTD PMID:20109541 NCBI chr19:54,395,746...54,398,348
Ensembl chr19:54,395,742...54,399,407 		JBrowse link
G Coasy Coenzyme A synthase decreases expression ISO tetrahydropalmatine results in decreased expression of COASY protein CTD PMID:20109541 NCBI chr10:86,014,566...86,018,849
Ensembl chr10:86,014,597...86,018,841 		JBrowse link
G Cops2 COP9 signalosome subunit 2 decreases expression ISO tetrahydropalmatine results in decreased expression of COPS2 protein CTD PMID:20109541 NCBI chr 3:113,084,174...113,110,090
Ensembl chr 3:113,084,176...113,109,947 		JBrowse link
G Cops3 COP9 signalosome subunit 3 decreases expression ISO tetrahydropalmatine results in decreased expression of COPS3 protein CTD PMID:20109541 NCBI chr10:44,618,115...44,652,807
Ensembl chr10:44,618,115...44,641,597 		JBrowse link
G Cox6c cytochrome c oxidase subunit 6C increases expression ISO tetrahydropalmatine results in increased expression of COX6C protein CTD PMID:20109541 NCBI chr 7:67,129,265...67,142,001
Ensembl chr 7:67,111,024...67,141,963 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression ISO tetrahydropalmatine results in decreased expression of CPT1A protein CTD PMID:20109541 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Crip2 cysteine-rich protein 2 decreases expression ISO tetrahydropalmatine results in decreased expression of CRIP2 protein CTD PMID:20109541 NCBI chr 6:132,221,120...132,226,066
Ensembl chr 6:132,221,082...132,226,065 		JBrowse link
G Cryz crystallin zeta decreases expression ISO tetrahydropalmatine results in decreased expression of CRYZ protein CTD PMID:20109541 NCBI chr 2:243,552,037...243,580,369
Ensembl chr 2:243,552,119...243,579,758 		JBrowse link
G Csde1 cold shock domain containing E1 decreases expression ISO tetrahydropalmatine results in decreased expression of CSDE1 protein CTD PMID:20109541 NCBI chr 2:190,546,015...190,582,787
Ensembl chr 2:190,554,980...190,582,784 		JBrowse link
G Cstb cystatin B increases expression ISO tetrahydropalmatine results in increased expression of CSTB protein CTD PMID:20109541 NCBI chr20:10,245,462...10,247,505
Ensembl chr20:10,245,462...10,247,526 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases expression ISO tetrahydropalmatine results in decreased expression of CYP1A2 mRNA; tetrahydropalmatine results in decreased expression of CYP1A2 protein CTD PMID:28257954 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Dcaf7 DDB1 and CUL4 associated factor 7 decreases expression ISO tetrahydropalmatine results in decreased expression of DCAF7 protein CTD PMID:20109541 NCBI chr10:90,974,095...90,996,275
Ensembl chr10:90,974,095...90,996,275 		JBrowse link
G Dctn2 dynactin subunit 2 decreases expression ISO tetrahydropalmatine results in decreased expression of DCTN2 protein CTD PMID:20109541 NCBI chr 7:63,092,061...63,107,560
Ensembl chr 7:63,092,057...63,108,543 		JBrowse link
G Ddx19b DEAD-box helicase 19B decreases expression ISO tetrahydropalmatine results in decreased expression of DDX19B protein CTD PMID:20109541 NCBI chr19:38,968,215...38,998,907
Ensembl chr19:38,968,215...38,997,259 		JBrowse link
G Ddx50 DExD-box helicase 50 decreases expression ISO tetrahydropalmatine results in decreased expression of DDX50 protein CTD PMID:20109541 NCBI chr20:30,561,623...30,591,324
Ensembl chr20:30,560,544...30,591,152 		JBrowse link
G Decr2 2,4-dienoyl-CoA reductase 2 increases expression ISO tetrahydropalmatine results in increased expression of DECR2 protein CTD PMID:20109541 NCBI chr10:15,104,907...15,113,281
Ensembl chr10:15,002,926...15,118,479 		JBrowse link
G Dhx8 DEAH-box helicase 8 increases expression ISO tetrahydropalmatine results in increased expression of DHX8 protein CTD PMID:20109541 NCBI chr10:86,667,641...86,704,198
Ensembl chr10:86,667,834...86,705,137 		JBrowse link
G Dnajb11 DnaJ heat shock protein family (Hsp40) member B11 decreases expression ISO tetrahydropalmatine results in decreased expression of DNAJB11 protein CTD PMID:20109541 NCBI chr11:78,151,750...78,168,259
Ensembl chr11:78,150,429...78,180,407 		JBrowse link
G Dpp3 dipeptidylpeptidase 3 decreases expression ISO tetrahydropalmatine results in decreased expression of DPP3 protein CTD PMID:20109541 NCBI chr 1:202,204,683...202,228,501
Ensembl chr 1:202,204,693...202,228,541 		JBrowse link
G Drd1 dopamine receptor D1 multiple interactions ISO tetrahydropalmatine binds to and results in decreased activity of DRD1 protein CTD PMID:17361394 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions ISO tetrahydropalmatine binds to and results in decreased activity of DRD2 protein CTD PMID:17361394 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Drd3 dopamine receptor D3 affects binding EXP tetrahydropalmatine binds to DRD3 protein CTD PMID:17361394 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596 		JBrowse link
G Dync1i2 dynein cytoplasmic 1 intermediate chain 2 decreases expression ISO tetrahydropalmatine results in decreased expression of DYNC1I2 protein CTD PMID:20109541 NCBI chr 3:56,033,882...56,085,080
Ensembl chr 3:56,033,917...56,085,080 		JBrowse link
G Dync1li2 dynein, cytoplasmic 1 light intermediate chain 2 decreases expression ISO tetrahydropalmatine results in decreased expression of DYNC1LI2 protein CTD PMID:20109541 NCBI chr19:531,783...554,670
Ensembl chr19:531,812...554,670 		JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 increases expression ISO tetrahydropalmatine results in increased expression of EEF1A1 protein CTD PMID:20109541 NCBI chr 8:79,341,554...79,344,784
Ensembl chr 8:79,341,557...79,344,839 		JBrowse link
G Eef1a2 eukaryotic translation elongation factor 1 alpha 2 decreases expression ISO tetrahydropalmatine results in decreased expression of EEF1A2 protein CTD PMID:20109541 NCBI chr 3:168,265,893...168,275,071
Ensembl chr 3:168,195,357...168,275,071 		JBrowse link
G Eif1 eukaryotic translation initiation factor 1 decreases expression ISO tetrahydropalmatine results in decreased expression of EIF1 protein CTD PMID:20109541 NCBI chr10:85,246,751...85,248,842
Ensembl chr10:85,246,764...85,427,327
Ensembl chr 5:85,246,764...85,427,327 		JBrowse link
G Eif4a2 eukaryotic translation initiation factor 4A2 decreases expression ISO tetrahydropalmatine results in decreased expression of EIF4A2 protein CTD PMID:20109541 NCBI chr11:77,764,126...77,770,810
Ensembl chr11:77,764,124...77,770,781 		JBrowse link
G Esr1 estrogen receptor 1 decreases expression
multiple interactions		 ISO
EXP		 tetrahydropalmatine results in decreased expression of ESR1 mRNA
tetrahydropalmatine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of ESR1 mRNA]		 CTD PMID:37606869 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Exoc8 exocyst complex component 8 decreases expression ISO tetrahydropalmatine results in decreased expression of EXOC8 protein CTD PMID:20109541 NCBI chr19:52,855,010...52,857,499
Ensembl chr19:52,852,578...52,857,491 		JBrowse link
G Faf2 Fas associated factor family member 2 decreases expression ISO tetrahydropalmatine results in decreased expression of FAF2 protein CTD PMID:20109541 NCBI chr17:9,947,211...9,989,474
Ensembl chr17:9,947,220...9,989,485 		JBrowse link
G Fah fumarylacetoacetate hydrolase decreases expression ISO tetrahydropalmatine results in decreased expression of FAH protein CTD PMID:20109541 NCBI chr 1:138,548,830...138,571,599
Ensembl chr 1:138,548,834...138,571,505 		JBrowse link
G Fam136a family with sequence similarity 136, member A decreases expression ISO tetrahydropalmatine results in decreased expression of FAM136A protein CTD PMID:20109541 NCBI chr 4:118,805,129...118,811,046
Ensembl chr 4:118,805,127...118,811,047 		JBrowse link
G Fkbp8 FKBP prolyl isomerase 8 decreases expression ISO tetrahydropalmatine results in decreased expression of FKBP8 protein CTD PMID:20109541 NCBI chr16:18,895,608...18,902,648
Ensembl chr16:18,893,576...18,902,612 		JBrowse link
G Flywch2 FLYWCH family member 2 decreases expression ISO tetrahydropalmatine results in decreased expression of FLYWCH2 protein CTD PMID:20109541 NCBI chr10:12,798,757...12,807,082
Ensembl chr10:12,798,762...12,806,439 		JBrowse link
G Fmr1 fragile X messenger ribonucleoprotein 1 decreases expression ISO tetrahydropalmatine results in decreased expression of FMR1 protein CTD PMID:20109541 NCBI chr  X:147,240,239...147,278,057
Ensembl chr  X:147,240,301...147,278,050 		JBrowse link
G Galk1 galactokinase 1 decreases expression ISO tetrahydropalmatine results in decreased expression of GALK1 protein CTD PMID:20109541 NCBI chr10:101,243,146...101,247,323
Ensembl chr10:101,235,994...101,247,337 		JBrowse link
G Ganab glucosidase II alpha subunit decreases expression ISO tetrahydropalmatine results in decreased expression of GANAB protein CTD PMID:20109541 NCBI chr 1:205,793,910...205,813,704
Ensembl chr 1:205,793,895...205,813,695 		JBrowse link
G Ggh gamma-glutamyl hydrolase increases expression ISO tetrahydropalmatine results in increased expression of GGH protein CTD PMID:20109541 NCBI chr 5:33,529,880...33,552,790
Ensembl chr 5:33,529,880...33,552,787 		JBrowse link
G Glrx glutaredoxin decreases expression ISO tetrahydropalmatine results in decreased expression of GLRX protein CTD PMID:20109541 NCBI chr 2:5,341,873...5,351,686
Ensembl chr 2:5,341,885...5,351,680 		JBrowse link
G Gmppb GDP-mannose pyrophosphorylase B increases expression ISO tetrahydropalmatine results in increased expression of GMPPB protein CTD PMID:20109541 NCBI chr 8:108,737,429...108,740,437
Ensembl chr 8:108,693,060...108,767,286 		JBrowse link
G Gpx4 glutathione peroxidase 4 decreases expression ISO tetrahydropalmatine results in decreased expression of GPX4 protein CTD PMID:20109541 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 multiple interactions EXP L-THP inhibits the reaction [Morphine increases expression of Gria1 protein in the striatum] RGD PMID:32717192 RGD:405100728 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases expression ISO tetrahydropalmatine results in decreased expression of GSK3B mRNA CTD PMID:37606869 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Gsn gelsolin decreases expression ISO tetrahydropalmatine results in decreased expression of GSN protein CTD PMID:20109541 NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402 		JBrowse link
G Gtpbp4 GTP binding protein 4 decreases expression ISO tetrahydropalmatine results in decreased expression of GTPBP4 protein CTD PMID:20109541 NCBI chr17:61,308,033...61,328,184
Ensembl chr17:61,308,014...61,418,009 		JBrowse link
G Hibch 3-hydroxyisobutyryl-CoA hydrolase increases expression ISO tetrahydropalmatine results in increased expression of HIBCH protein CTD PMID:20109541 NCBI chr 9:48,590,097...48,669,896
Ensembl chr 9:48,590,099...48,669,824 		JBrowse link
G Hint2 histidine triad nucleotide binding protein 2 decreases expression ISO tetrahydropalmatine results in decreased expression of HINT2 protein CTD PMID:20109541 NCBI chr 5:57,904,613...57,906,868
Ensembl chr 5:57,904,614...57,907,097 		JBrowse link
G Hk1 hexokinase 1 decreases expression
increases expression		 ISO tetrahydropalmatine results in decreased expression of HK1 protein
tetrahydropalmatine results in increased expression of HK1 protein		 CTD PMID:20109541 NCBI chr20:30,230,488...30,332,099
Ensembl chr20:30,230,486...30,332,131 		JBrowse link
G Hmga1 high mobility group AT-hook 1 decreases expression ISO tetrahydropalmatine results in decreased expression of HMGA1 protein CTD PMID:20109541 NCBI chr20:5,611,088...5,618,755
Ensembl chr20:5,611,694...5,618,752 		JBrowse link
G Hmox1 heme oxygenase 1 decreases expression ISO tetrahydropalmatine results in decreased expression of HMOX1 protein CTD PMID:20109541 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hnrnpul2 heterogeneous nuclear ribonucleoprotein U-like 2 increases expression ISO tetrahydropalmatine results in increased expression of HNRNPUL2 protein CTD PMID:20109541 NCBI chr 1:205,713,431...205,725,553
Ensembl chr 1:205,711,886...205,725,553 		JBrowse link
G Igf2bp3 insulin-like growth factor 2 mRNA binding protein 3 decreases expression ISO tetrahydropalmatine results in decreased expression of IGF2BP3 protein CTD PMID:20109541 NCBI chr 4:78,060,494...78,195,007
Ensembl chr 4:78,060,494...78,194,865 		JBrowse link
G Ipo9 importin 9 decreases expression ISO tetrahydropalmatine results in decreased expression of IPO9 protein CTD PMID:20109541 NCBI chr13:46,810,460...46,862,694
Ensembl chr13:46,813,171...46,862,673 		JBrowse link
G Iqgap3 IQ motif containing GTPase activating protein 3 decreases expression ISO tetrahydropalmatine results in decreased expression of IQGAP3 protein CTD PMID:20109541 NCBI chr 2:173,542,151...173,583,956
Ensembl chr 2:173,542,110...173,583,956 		JBrowse link
G Jpt2 Jupiter microtubule associated homolog 2 decreases expression ISO tetrahydropalmatine results in decreased expression of JPT2 protein CTD PMID:20109541 NCBI chr10:13,963,135...13,983,212
Ensembl chr10:13,963,137...13,983,170 		JBrowse link
G Letm1 leucine zipper and EF-hand containing transmembrane protein 1 decreases expression ISO tetrahydropalmatine results in decreased expression of LETM1 protein CTD PMID:20109541 NCBI chr14:76,942,647...76,982,220
Ensembl chr14:76,942,729...76,984,904 		JBrowse link
G Lta4h leukotriene A4 hydrolase decreases expression ISO tetrahydropalmatine results in decreased expression of LTA4H protein CTD PMID:20109541 NCBI chr 7:27,969,796...28,001,600
Ensembl chr 7:27,969,789...28,001,600 		JBrowse link
G Mak16 MAK16 homolog decreases expression ISO tetrahydropalmatine results in decreased expression of MAK16 protein CTD PMID:20109541 NCBI chr16:60,972,699...60,981,250
Ensembl chr16:60,972,697...60,983,243 		JBrowse link
G Man1b1 mannosidase, alpha, class 1B, member 1 increases expression ISO tetrahydropalmatine results in increased expression of MAN1B1 protein CTD PMID:20109541 NCBI chr 3:8,143,877...8,165,007
Ensembl chr 3:8,143,381...8,165,006 		JBrowse link
G Map1b microtubule-associated protein 1B increases expression ISO tetrahydropalmatine results in increased expression of MAP1B protein CTD PMID:20109541 NCBI chr 2:30,817,261...30,910,458
Ensembl chr 2:30,817,261...30,910,317 		JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 decreases expression ISO tetrahydropalmatine results in decreased expression of MAP2K2 protein CTD PMID:20109541 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243 		JBrowse link
G Metap2 methionyl aminopeptidase 2 decreases expression ISO tetrahydropalmatine results in decreased expression of METAP2 protein CTD PMID:20109541 NCBI chr 7:28,412,429...28,440,458
Ensembl chr 7:28,411,608...28,440,434 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO tetrahydropalmatine results in decreased expression of MMP9 mRNA CTD PMID:37606869 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases expression ISO tetrahydropalmatine results in decreased expression of MTOR protein CTD PMID:20109541 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Ncaph non-SMC condensin I complex, subunit H increases expression ISO tetrahydropalmatine results in increased expression of NCAPH protein CTD PMID:20109541 NCBI chr 3:114,371,937...114,399,178
Ensembl chr 3:114,371,941...114,399,180 		JBrowse link
G Nceh1 neutral cholesterol ester hydrolase 1 decreases expression ISO tetrahydropalmatine results in decreased expression of NCEH1 protein CTD PMID:20109541 NCBI chr 2:110,074,985...110,135,592
Ensembl chr 2:110,074,957...110,135,588 		JBrowse link
G Ndufb5 NADH:ubiquinone oxidoreductase subunit B5 decreases expression ISO tetrahydropalmatine results in decreased expression of NDUFB5 protein CTD PMID:20109541 NCBI chr 2:115,519,248...115,533,589
Ensembl chr 2:115,519,154...115,533,589 		JBrowse link
G Nelfe negative elongation factor complex member E decreases expression ISO tetrahydropalmatine results in decreased expression of NELFE protein CTD PMID:20109541 NCBI chr20:3,976,512...3,982,389
Ensembl chr20:3,976,518...3,982,355 		JBrowse link
G Nfu1 NFU1 iron-sulfur cluster scaffold decreases expression ISO tetrahydropalmatine results in decreased expression of NFU1 protein CTD PMID:20109541 NCBI chr 4:119,458,981...119,480,162
Ensembl chr 4:119,459,061...119,480,373 		JBrowse link
G Nipsnap1 nipsnap homolog 1 increases expression ISO tetrahydropalmatine results in increased expression of NIPSNAP1 protein CTD PMID:20109541 NCBI chr14:79,734,234...79,758,101
Ensembl chr14:79,734,209...79,758,098 		JBrowse link
G Nubp2 NUBP iron-sulfur cluster assembly factor 2 decreases expression ISO tetrahydropalmatine results in decreased expression of NUBP2 protein CTD PMID:20109541 NCBI chr10:13,903,224...13,906,928
Ensembl chr10:13,903,224...13,906,969 		JBrowse link
G Nufip2 nuclear FMR1 interacting protein 2 decreases expression ISO tetrahydropalmatine results in decreased expression of NUFIP2 protein CTD PMID:20109541 NCBI chr10:62,574,922...62,607,729
Ensembl chr10:62,574,882...62,600,346 		JBrowse link
G Nup155 nucleoporin 155 decreases expression ISO tetrahydropalmatine results in decreased expression of NUP155 protein CTD PMID:20109541 NCBI chr 2:57,201,310...57,252,918
Ensembl chr 2:57,201,272...57,254,148 		JBrowse link
G Palld palladin, cytoskeletal associated protein decreases expression ISO tetrahydropalmatine results in decreased expression of PALLD protein CTD PMID:20109541 NCBI chr16:28,228,006...28,621,349
Ensembl chr16:27,981,354...28,621,337 		JBrowse link
G Pawr pro-apoptotic WT1 regulator decreases expression ISO tetrahydropalmatine results in decreased expression of PAWR protein CTD PMID:20109541 NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028 		JBrowse link
G Pds5a PDS5 cohesin associated factor A increases expression ISO tetrahydropalmatine results in increased expression of PDS5A protein CTD PMID:20109541 NCBI chr14:42,551,653...42,651,074
Ensembl chr14:42,552,647...42,648,669 		JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein increases expression ISO tetrahydropalmatine results in increased expression of PICALM protein CTD PMID:20109541 NCBI chr 1:144,056,415...144,138,045
Ensembl chr 1:144,056,721...144,137,557 		JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 decreases expression ISO tetrahydropalmatine results in decreased expression of PIN1 protein CTD PMID:20109541 NCBI chr 8:19,189,408...19,200,785
Ensembl chr 8:19,189,373...19,200,785 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP tetrahydropalmatine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of PPARG mRNA] CTD PMID:37606869 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppil3 peptidylprolyl isomerase like 3 decreases expression ISO tetrahydropalmatine results in decreased expression of PPIL3 protein CTD PMID:20109541 NCBI chr 9:59,966,405...59,980,147
Ensembl chr 9:59,964,919...59,979,886 		JBrowse link
G Ppp2cb protein phosphatase 2 catalytic subunit beta decreases expression ISO tetrahydropalmatine results in decreased expression of PPP2CB protein CTD PMID:20109541 NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576 		JBrowse link
G Praf2 PRA1 domain family, member 2 increases expression ISO tetrahydropalmatine results in increased expression of PRAF2 protein CTD PMID:20109541 NCBI chr  X:14,773,398...14,776,035
Ensembl chr  X:14,773,420...14,775,909 		JBrowse link
G Prkar1a protein kinase cAMP-dependent type I regulatory subunit alpha decreases expression ISO tetrahydropalmatine results in decreased expression of PRKAR1A protein CTD PMID:20109541 NCBI chr10:94,621,042...94,639,534
Ensembl chr10:94,620,039...94,639,041 		JBrowse link
G Prkca protein kinase C, alpha decreases expression ISO tetrahydropalmatine results in decreased expression of PRKCA protein CTD PMID:20109541 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
G Prpf4 pre-mRNA splicing tri-snRNP complex factor 4 decreases expression ISO tetrahydropalmatine results in decreased expression of PRPF4 protein CTD PMID:20109541 NCBI chr 5:75,859,934...75,873,924
Ensembl chr 5:75,859,924...75,873,919 		JBrowse link
G Prpsap1 phosphoribosyl pyrophosphate synthetase-associated protein 1 decreases expression ISO tetrahydropalmatine results in decreased expression of PRPSAP1 protein CTD PMID:20109541 NCBI chr10:101,701,094...101,750,753
Ensembl chr10:101,701,096...101,750,751 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO tetrahydropalmatine results in decreased expression of PTGS2 mRNA CTD PMID:37606869 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Pym1 PYM homolog 1, exon junction complex associated factor decreases expression ISO tetrahydropalmatine results in decreased expression of PYM1 protein CTD PMID:20109541 NCBI chr 7:1,177,746...1,200,899
Ensembl chr 7:1,178,008...1,198,937 		JBrowse link
G Rab3gap1 RAB3 GTPase activating protein catalytic subunit 1 decreases expression ISO tetrahydropalmatine results in decreased expression of RAB3GAP1 protein CTD PMID:20109541 NCBI chr13:39,355,698...39,429,154
Ensembl chr13:39,352,247...39,429,169 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase increases expression ISO tetrahydropalmatine results in increased expression of RAF1 protein CTD PMID:20109541 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317 		JBrowse link
G Ranbp2 RAN binding protein 2 decreases expression ISO tetrahydropalmatine results in decreased expression of RANBP2 protein CTD PMID:20109541 NCBI chr20:26,442,156...26,493,481
Ensembl chr20:26,442,217...26,493,481 		JBrowse link
G Rbm39 RNA binding motif protein 39 decreases expression
increases expression		 ISO tetrahydropalmatine results in decreased expression of RBM39 protein
tetrahydropalmatine results in increased expression of RBM39 protein		 CTD PMID:20109541 NCBI chr 3:144,662,998...144,696,222
Ensembl chr 3:144,663,001...144,696,213 		JBrowse link
G Reep5 receptor accessory protein 5 decreases expression ISO tetrahydropalmatine results in decreased expression of REEP5 protein CTD PMID:20109541 NCBI chr18:25,945,375...25,983,271
Ensembl chr18:25,945,381...25,976,509 		JBrowse link
G Rfc4 replication factor C subunit 4 increases expression ISO tetrahydropalmatine results in increased expression of RFC4 protein CTD PMID:20109541 NCBI chr11:77,749,642...77,764,123
Ensembl chr11:77,749,638...77,764,122 		JBrowse link
G Rhob ras homolog family member B decreases expression ISO tetrahydropalmatine results in decreased expression of RHOB protein CTD PMID:20109541 NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108 		JBrowse link
G Rmnd5a required for meiotic nuclear division 5 homolog A increases expression ISO tetrahydropalmatine results in increased expression of RMND5A protein CTD PMID:20109541 NCBI chr 4:103,375,846...103,432,890
Ensembl chr 4:103,379,908...103,433,051 		JBrowse link
G Rnf40 ring finger protein 40 decreases expression ISO tetrahydropalmatine results in decreased expression of RNF40 protein CTD PMID:20109541 NCBI chr 1:182,202,475...182,217,899
Ensembl chr 1:182,202,600...182,217,241 		JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 decreases expression ISO tetrahydropalmatine results in decreased expression of ROCK2 protein CTD PMID:20109541 NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031 		JBrowse link
G Rpa2 replication protein A2 decreases expression ISO tetrahydropalmatine results in decreased expression of RPA2 protein CTD PMID:20109541 NCBI chr 5:144,976,789...144,989,445
Ensembl chr 5:144,976,748...144,987,350 		JBrowse link
G Rps28 ribosomal protein S28 decreases expression ISO tetrahydropalmatine results in decreased expression of RPS28 protein CTD PMID:20109541 NCBI chr 7:14,607,801...14,609,170
Ensembl chr 7:14,607,801...14,609,170
Ensembl chr16:14,607,801...14,609,170
Ensembl chr16:14,607,801...14,609,170 		JBrowse link
G Rps6ka3 ribosomal protein S6 kinase A3 increases expression ISO tetrahydropalmatine results in increased expression of RPS6KA3 protein CTD PMID:20109541 NCBI chr  X:35,517,306...35,623,296
Ensembl chr  X:35,517,306...35,623,207 		JBrowse link
G Septin11 septin 11 decreases expression ISO tetrahydropalmatine results in decreased expression of SEPTIN11 protein CTD PMID:20109541 NCBI chr14:14,844,759...14,990,856
Ensembl chr14:14,844,580...14,990,853 		JBrowse link
G Skic3 SKI3 subunit of superkiller complex decreases expression ISO tetrahydropalmatine results in decreased expression of SKIC3 protein CTD PMID:20109541 NCBI chr 2:5,631,544...5,783,643
Ensembl chr 2:5,631,635...5,751,626 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO tetrahydropalmatine inhibits the reaction [SLC22A1 protein results in increased uptake of Monocrotaline]; tetrahydropalmatine inhibits the reaction [SLC22A1 protein results in increased uptake of retrorsine] CTD PMID:23831208 PMID:24799337 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO tetrahydropalmatine inhibits the reaction [SLC22A2 protein results in increased import of Oxaliplatin] CTD PMID:34252480 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc22a4 solute carrier family 22 member 4 multiple interactions ISO tetrahydropalmatine inhibits the reaction [SLC22A4 protein results in increased import of Oxaliplatin] CTD PMID:34252480 NCBI chr10:38,133,333...38,179,932
Ensembl chr10:38,133,322...38,179,720 		JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions ISO tetrahydropalmatine inhibits the reaction [SLC22A5 protein results in increased import of Oxaliplatin] CTD PMID:34252480 NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309 		JBrowse link
G Slc25a10 solute carrier family 25 member 10 increases expression ISO tetrahydropalmatine results in increased expression of SLC25A10 protein CTD PMID:20109541 NCBI chr10:105,765,598...105,775,159
Ensembl chr10:105,765,372...105,773,556 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 decreases expression ISO tetrahydropalmatine results in decreased expression of SLC6A4 mRNA CTD PMID:37606869 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384 		JBrowse link
G Smarca5 SNF2 related chromatin remodeling ATPase 5 decreases expression ISO tetrahydropalmatine results in decreased expression of SMARCA5 protein CTD PMID:20109541 NCBI chr19:27,271,918...27,304,594
Ensembl chr19:27,271,148...27,304,594 		JBrowse link
G Sms spermine synthase decreases expression ISO tetrahydropalmatine results in decreased expression of SMS protein CTD PMID:20109541 NCBI chr  X:37,516,949...37,572,657
Ensembl chr  X:37,516,931...37,570,822
Ensembl chr 3:37,516,931...37,570,822 		JBrowse link
G Sncg synuclein, gamma decreases expression ISO tetrahydropalmatine results in decreased expression of SNCG protein CTD PMID:20109541 NCBI chr16:9,700,513...9,705,751
Ensembl chr16:9,700,514...9,705,368 		JBrowse link
G Snrpe small nuclear ribonucleoprotein polypeptide E decreases expression ISO tetrahydropalmatine results in decreased expression of SNRPE protein CTD PMID:20109541 NCBI chr13:45,050,986...45,057,231
Ensembl chr13:45,050,986...45,057,310
Ensembl chr 8:45,050,986...45,057,310 		JBrowse link
G Snw1 SNW domain containing 1 decreases expression ISO tetrahydropalmatine results in decreased expression of SNW1 protein CTD PMID:20109541 NCBI chr 6:107,095,450...107,119,536
Ensembl chr 6:107,095,457...107,119,536 		JBrowse link
G Snx1 sorting nexin 1 decreases expression ISO tetrahydropalmatine results in decreased expression of SNX1 protein CTD PMID:20109541 NCBI chr 8:66,630,086...66,670,418
Ensembl chr 8:66,630,086...66,670,360 		JBrowse link
G Snx2 sorting nexin 2 decreases expression ISO tetrahydropalmatine results in decreased expression of SNX2 protein CTD PMID:20109541 NCBI chr18:46,602,223...46,643,870
Ensembl chr18:46,602,284...46,643,865 		JBrowse link
G Spdl1 spindle apparatus coiled-coil protein 1 decreases expression ISO tetrahydropalmatine results in decreased expression of SPDL1 protein CTD PMID:20109541 NCBI chr10:19,269,125...19,294,213
Ensembl chr10:19,269,127...19,294,127 		JBrowse link
G Sri sorcin decreases expression ISO tetrahydropalmatine results in decreased expression of SRI protein CTD PMID:20109541 NCBI chr 4:25,973,493...25,997,879
Ensembl chr 4:25,966,750...25,998,077 		JBrowse link
G Srp19 signal recognition particle 19 decreases expression ISO tetrahydropalmatine results in decreased expression of SRP19 protein CTD PMID:20109541 NCBI chr18:25,931,734...25,937,974
Ensembl chr18:25,931,589...25,938,017 		JBrowse link
G Srp68 signal recognition particle 68 decreases expression ISO tetrahydropalmatine results in decreased expression of SRP68 protein CTD PMID:20109541 NCBI chr10:101,481,213...101,508,035
Ensembl chr10:101,481,212...101,508,035 		JBrowse link
G Srpra SRP receptor subunit alpha decreases expression ISO tetrahydropalmatine results in decreased expression of SRPRA protein CTD PMID:20109541 NCBI chr 8:33,560,365...33,566,458
Ensembl chr 8:33,560,348...33,566,470 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 increases expression ISO tetrahydropalmatine results in increased expression of STAT1 protein CTD PMID:20109541 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Stxbp1 syntaxin binding protein 1 decreases expression ISO tetrahydropalmatine results in decreased expression of STXBP1 protein CTD PMID:20109541 NCBI chr 3:16,076,725...16,138,431
Ensembl chr 3:16,076,391...16,138,369 		JBrowse link
G Swap70 switching B-cell complex subunit SWAP70 increases expression ISO tetrahydropalmatine results in increased expression of SWAP70 protein CTD PMID:20109541 NCBI chr 1:164,267,588...164,328,796
Ensembl chr 1:164,267,609...164,328,794 		JBrowse link
G Syvn1 synoviolin 1 decreases expression ISO tetrahydropalmatine results in decreased expression of SYVN1 protein CTD PMID:20109541 NCBI chr 1:203,339,235...203,346,137
Ensembl chr 1:203,339,619...203,346,152 		JBrowse link
G Tma7 translation machinery associated 7 homolog decreases expression ISO tetrahydropalmatine results in decreased expression of TMA7 protein CTD PMID:20109541 NCBI chr 8:109,726,213...109,730,902
Ensembl chr 8:109,726,196...109,735,474 		JBrowse link
G Tmed4 transmembrane p24 trafficking protein 4 decreases expression ISO tetrahydropalmatine results in decreased expression of TMED4 protein CTD PMID:20109541 NCBI chr14:81,125,049...81,129,646
Ensembl chr14:81,125,053...81,129,631 		JBrowse link
G Top1 DNA topoisomerase I increases expression ISO tetrahydropalmatine results in increased expression of TOP1 protein CTD PMID:20109541 NCBI chr 3:149,293,469...149,376,618
Ensembl chr 3:149,293,403...149,376,623 		JBrowse link
G Tsnax translin-associated factor X decreases expression ISO tetrahydropalmatine results in decreased expression of TSNAX protein CTD PMID:20109541 NCBI chr19:52,975,848...52,989,886
Ensembl chr19:52,975,659...52,989,878 		JBrowse link
G Tsr2 TSR2, ribosome maturation factor increases expression ISO tetrahydropalmatine results in increased expression of TSR2 protein CTD PMID:20109541 NCBI chr  X:20,064,102...20,072,673
Ensembl chr  X:20,064,103...20,072,620 		JBrowse link
G Uap1 UDP-N-acetylglucosamine pyrophosphorylase 1 increases expression ISO tetrahydropalmatine results in increased expression of UAP1 protein CTD PMID:20109541 NCBI chr13:82,342,946...82,377,558
Ensembl chr13:82,342,946...82,377,469
Ensembl chr 6:82,342,946...82,377,469 		JBrowse link
G Vps45 vacuolar protein sorting 45 homolog increases expression ISO tetrahydropalmatine results in increased expression of VPS45 protein CTD PMID:20109541 NCBI chr 2:183,555,919...183,616,312
Ensembl chr 2:183,555,921...183,616,295 		JBrowse link
G Wdhd1 WD repeat and HMG-box DNA binding protein 1 increases expression ISO tetrahydropalmatine results in increased expression of WDHD1 protein CTD PMID:20109541 NCBI chr15:20,478,310...20,523,106
Ensembl chr15:20,489,291...20,523,096 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      biological role 19842
        pharmacological role 19072
          analgesic 14769
            non-narcotic analgesic 13923
              tetrahydropalmatine 159
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            organic molecule 19700
                              organic cyclic compound 19490
                                organic heterocyclic compound 18868
                                  organonitrogen heterocyclic compound 18148
                                    dibenzoquinolizine 414
                                      berberine alkaloid 414
                                        palmatine 188
                                          tetrahydropalmatine 159
paths to the root