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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:gossypetin
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Accession:CHEBI:16400 term browser browse the term
Definition:A hexahydroxyflavone having the hydroxy groups placed at the 3-, 3'-, 4'-, 5- 7- and 8-positions.
Synonyms:exact_synonym: 2-(3,4-dihydroxyphenyl)-3,5,7,8-tetrahydroxy-4H-chromen-4-one
 related_synonym: 3,3',4',5,7,8-Hexahydroxyflavone;   Articulatidin;   Equisporol;   Formula=C15H10O8;   InChI=1S/C15H10O8/c16-6-2-1-5(3-7(6)17)14-13(22)12(21)10-8(18)4-9(19)11(20)15(10)23-14/h1-4,16-20,22H;   InChIKey=YRRAGUMVDQQZIY-UHFFFAOYSA-N;   SMILES=Oc1ccc(cc1O)-c1oc2c(O)c(O)cc(O)c2c(=O)c1O
 alt_id: CHEBI:11682;   CHEBI:1362;   CHEBI:19860;   CHEBI:38341
 xref: CAS:489-35-0;   KEGG:C04109;   KNApSAcK:C00004721;   LINCS:LSM-36971;   LIPID_MAPS_instance:LMPK12113231
 xref_mesh: MESH:C059922
 xref: MetaCyc:334578-HEXAHYDROXYFLAVONE;   PMID:19895818;   PMID:22953867;   PMID:2676226;   PMID:8424824;   Patent:JP55054883;   Patent:WO0103681;   Reaxys:332194;   Wikipedia:Gossypetin
 cyclic_relationship: is_conjugate_acid_of CHEBI:57759;   is_conjugate_acid_of CHEBI:77862


show annotations for term's descendants           Sort by:
gossypetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg12 autophagy related 12 multiple interactions ISO gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [ATG5 protein binds to ATG12 protein]] CTD PMID:25622137 NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418 		JBrowse link
G Atg5 autophagy related 5 multiple interactions ISO gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [ATG5 protein binds to ATG12 protein]] CTD PMID:25622137 NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Becn1 beclin 1 multiple interactions
increases response to substance		 ISO 3-methyladenine inhibits the reaction [gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [BECN1 protein binds to PIK3C3 protein]]]; gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [BECN1 protein binds to PIK3C3 protein]]; gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of BECN1 protein]
BECN1 protein results in increased susceptibility to gossypetin		 CTD PMID:25622137 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO gossypetin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased cleavage of CASP3 protein] CTD PMID:25622137 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO gossypetin results in increased expression of CYP1A1 mRNA CTD PMID:29584932 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human results in decreased phosphorylation of MTOR protein] CTD PMID:25622137 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 decreases activity
multiple interactions		 ISO gossypetin results in decreased activity of PARP1 protein
gossypetin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased cleavage of PARP1 protein]		 CTD PMID:17884996 PMID:25622137 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 multiple interactions ISO 3-methyladenine inhibits the reaction [gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [BECN1 protein binds to PIK3C3 protein]]]; 3-methyladenine inhibits the reaction [gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of PIK3C3 protein]]; gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [BECN1 protein binds to PIK3C3 protein]]; gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of PIK3C3 protein] CTD PMID:25622137 NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha affects response to substance ISO PPARA protein affects the susceptibility to gossypetin CTD PMID:23845592 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects response to substance ISO PPARG protein affects the susceptibility to gossypetin CTD PMID:23845592 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Pten phosphatase and tensin homolog increases expression
multiple interactions		 ISO gossypetin results in increased expression of PTEN protein
Enzyme Inhibitors inhibits the reaction [gossypetin results in increased expression of PTEN protein]		 CTD PMID:25622137 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO gossypetin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of SQSTM1 protein] CTD PMID:25622137 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
gossypin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf1 activating transcription factor 1 multiple interactions
decreases phosphorylation		 ISO gossypin inhibits the reaction [EGF protein results in increased phosphorylation of ATF1 protein]
gossypin results in decreased phosphorylation of ATF1 protein		 CTD PMID:30536456 NCBI chr 7:131,361,962...131,404,677
Ensembl chr 7:131,362,450...131,404,670 		JBrowse link
G Aurka aurora kinase A multiple interactions ISO gossypin binds to and results in decreased activity of AURKA protein CTD PMID:30536456 NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO gossypin results in decreased expression of BCL2L1 protein CTD PMID:30536456 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Casp3 caspase 3 increases cleavage ISO gossypin results in increased cleavage of CASP3 protein CTD PMID:30536456 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 increases cleavage ISO gossypin results in increased cleavage of CASP7 protein CTD PMID:30536456 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp9 caspase 9 increases cleavage ISO gossypin results in increased cleavage of CASP9 protein CTD PMID:30536456 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions EXP gossypin inhibits the reaction [Lipopolysaccharides results in decreased expression of CAT protein]; gossypin inhibits the reaction [Oleic Acid results in increased activity of CAT protein] CTD PMID:37148149 PMID:37696682 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccna2 cyclin A2 decreases expression ISO gossypin results in decreased expression of CCNA2 protein CTD PMID:30536456 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO gossypin results in decreased expression of CCNB1 protein CTD PMID:30536456 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases phosphorylation ISO gossypin results in decreased phosphorylation of CDK1 protein CTD PMID:30536456 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Crp C-reactive protein multiple interactions EXP gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of CRP protein] CTD PMID:37148149 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO gossypin inhibits the reaction [EGF protein results in increased phosphorylation of ATF1 protein] CTD PMID:30536456 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP gossypin inhibits the reaction [Lipopolysaccharides results in decreased expression of HMOX1 protein] CTD PMID:37148149 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP gossypin inhibits the reaction [Lipopolysaccharides results in decreased expression of IL10 protein] CTD PMID:37148149 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il13 interleukin 13 multiple interactions EXP gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of IL13 protein] CTD PMID:37148149 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il17a interleukin 17A multiple interactions EXP gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of IL17A protein] CTD PMID:37148149 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il18 interleukin 18 multiple interactions EXP gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 protein] CTD PMID:37148149 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; gossypin inhibits the reaction [Oleic Acid results in increased expression of IL1B mRNA] CTD PMID:37148149 PMID:37696682 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il4 interleukin 4 multiple interactions EXP gossypin inhibits the reaction [Lipopolysaccharides results in decreased expression of IL4 protein] CTD PMID:37148149 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il5 interleukin 5 multiple interactions EXP gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of IL5 protein] CTD PMID:37148149 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; gossypin inhibits the reaction [Oleic Acid results in increased expression of IL6 mRNA] CTD PMID:37148149 PMID:37696682 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases phosphorylation ISO gossypin results in decreased phosphorylation of JUN protein CTD PMID:30536456 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of MPO protein] CTD PMID:37148149 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP gossypin inhibits the reaction [Lipopolysaccharides results in decreased expression of NFE2L2 protein] CTD PMID:37148149 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO gossypin results in increased cleavage of PARP1 protein CTD PMID:30536456 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:37148149 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rps6ka3 ribosomal protein S6 kinase A3 multiple interactions ISO gossypin binds to and results in decreased activity of RPS6KA3 protein CTD PMID:30536456 NCBI chr  X:35,517,306...35,623,296
Ensembl chr  X:35,517,306...35,623,207 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of TGFB1 protein] CTD PMID:37148149 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; gossypin inhibits the reaction [Oleic Acid results in increased expression of TNF mRNA]; gossypin inhibits the reaction [Oleic Acid results in increased expression of TNF protein] CTD PMID:37148149 PMID:37696682 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      biological role 19848
        biochemical role 19556
          metabolite 19544
            eukaryotic metabolite 19368
              plant metabolite 17985
                gossypetin 39
                  2,3-dihydrogossypetin 0
                  3,3',4',5,7-pentahydroxy-8-methoxyflavone 0
                  gossypetin 8-rhamnoside 0
                  gossypin 29
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            organic molecule 19706
                              organic cyclic compound 19495
                                organic heterocyclic compound 18874
                                  oxacycle 17906
                                    benzopyran 11972
                                      1-benzopyran 11726
                                        flavonoid 7226
                                          anthoxanthin 4585
                                            flavones 4585
                                              hydroxyflavone 4562
                                                flavonols 4428
                                                  7-hydroxyflavonol 4393
                                                    gossypetin 39
                                                      2,3-dihydrogossypetin 0
                                                      3,3',4',5,7-pentahydroxy-8-methoxyflavone 0
                                                      gossypetin 8-rhamnoside 0
                                                      gossypin 29
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