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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:FAD
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Accession:CHEBI:16238 term browser browse the term
Definition:A flavin adenine dinucleotide in which the substituent at position 10 of the flavin nucleus is a 5'-adenosyldiphosphoribityl group.
Synonyms:exact_synonym: adenosine 5'-(3-{D-ribo-5-[7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl]-2,3,4-trihydroxypentyl} dihydrogen diphosphate)
 related_synonym: Adenosine 5'-(trihydrogen pyrophosphate), 5'-5'-ester with riboflavine;   Flavin adenine dinucleotide;   Formula=C27H33N9O15P2;   InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1;   InChIKey=VWWQXMAJTJZDQX-UYBVJOGSSA-N;   Riboflavin 5'-(trihydrogen diphosphate), 5'-5'-ester with adenosine;   Riboflavin 5'-adenosine diphosphate;   SMILES=Cc1cc2nc3c(nc(=O)[nH]c3=O)n(C[C@H](O)[C@H](O)[C@H](O)COP(O)(=O)OP(O)(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c(N)ncnc34)c2cc1C;   adenosine 5'-[3-(riboflavin-5'-yl) dihydrogen diphosphate]
 alt_id: CHEBI:13315;   CHEBI:21125;   CHEBI:42388;   CHEBI:4956
 xref: Beilstein:1208946;   CAS:146-14-5;   COMe:MOL000039;   DrugBank:DB03147;   Gmelin:108834;   KEGG:C00016;   KEGG:D00005;   KNApSAcK:C00001500
 xref_mesh: MESH:D005182
 xref: PDBeChem:FAD;   PMID:24643482;   PMID:25108762
 cyclic_relationship: is_conjugate_acid_of CHEBI:57692


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FAD term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ndufa9 NADH:ubiquinone oxidoreductase subunit A9 multiple interactions ISO Flavin-Adenine Dinucleotide binds to and results in increased activity of NDUFA9 protein CTD PMID:25526675 NCBI chr 4:159,659,242...159,688,034
Ensembl chr 4:159,659,242...159,688,018 		JBrowse link
G Rfk riboflavin kinase increases abundance ISO RFK protein results in increased abundance of Flavin-Adenine Dinucleotide CTD PMID:21308351 NCBI chr 1:214,799,880...214,807,440
Ensembl chr 1:214,799,825...214,807,438
Ensembl chr  X:214,799,825...214,807,438 		JBrowse link
G Slc52a3 solute carrier family 52 member 3 multiple interactions EXP Flavin-Adenine Dinucleotide inhibits the reaction [SLC52A3 protein results in increased transport of Riboflavin] CTD PMID:19122205 NCBI chr 3:140,498,924...140,515,845
Ensembl chr 3:140,509,473...140,514,096 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      biological role 19852
        biochemical role 19582
          cofactor 16588
            FAD 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    p-block element atom 19849
                      chalcogen 19598
                        oxygen atom 19570
                          oxygen molecular entity 19570
                            hydroxides 19374
                              oxoacid 18808
                                pnictogen oxoacid 14987
                                  phosphorus oxoacid 14587
                                    phosphoric acids 13935
                                      phosphoric acid 13935
                                        phosphoric acid derivative 13817
                                          phosphate 13843
                                            organic phosphate 13816
                                              nucleoside phosphate 1862
                                                nucleotide 1953
                                                  flavin nucleotide 4
                                                    flavin adenine dinucleotide 3
                                                      FAD 3
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