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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:coformycin
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Accession:CHEBI:16213 term browser browse the term
Definition:An N-glycosyl in which (8R)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol is attached to ribofuranose via a beta-N(3)-glycosidic bond. compound The parent of the class of coformycins.
Synonyms:exact_synonym: (8R)-3-beta-D-ribofuranosyl-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol
 related_synonym: (R)-3,4,7,8-Tetrahydro-3-beta-D-ribofuranosylimidazo(4,5-d)(1,3)diazepin-8-ol;   Formula=C11H16N4O5;   InChI=1S/C11H16N4O5/c16-2-6-8(18)9(19)11(20-6)15-4-14-7-5(17)1-12-3-13-10(7)15/h3-6,8-9,11,16-19H,1-2H2,(H,12,13)/t5-,6-,8-,9-,11-/m1/s1;   InChIKey=YOOVTUPUBVHMPG-LODYRLCVSA-N;   SMILES=OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2[C@H](O)CNC=Nc12
 alt_id: CHEBI:14013;   CHEBI:23358;   CHEBI:3810
 xref: CAS:11033-22-0;   KEGG:C01677
 xref_mesh: MESH:D003070
 xref: MetaCyc:COFORMYCIN;   PMID:11913523;   PMID:14630012;   PMID:6860359;   PMID:7204504;   Reaxys:5609987
 cyclic_relationship: is_conjugate_base_of CHEBI:57682


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coformycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Faslg Fas ligand multiple interactions ISO [Adenosine co-treated with Coformycin] results in decreased expression of FASL mRNA CTD PMID:11992407 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Gzmb granzyme B multiple interactions ISO [Adenosine co-treated with Coformycin] results in decreased expression of GZMB mRNA CTD PMID:11992407 NCBI chr15:30,343,352...30,346,814
Ensembl chr15:30,173,603...30,346,814 		JBrowse link
G Ifng interferon gamma multiple interactions ISO [Adenosine co-treated with Coformycin] results in decreased expression of IFNG protein CTD PMID:11992407 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Adenosine co-treated with Coformycin] results in decreased expression of IL2 protein CTD PMID:11992407 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Prf1 perforin 1 multiple interactions ISO [Adenosine co-treated with Coformycin] results in decreased expression of PRF1 mRNA CTD PMID:11992407 NCBI chr20:29,246,202...29,251,712
Ensembl chr20:29,246,202...29,251,701 		JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO [Adenosine co-treated with Coformycin] results in decreased expression of TNFSF10 mRNA CTD PMID:11992407 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19867
    role 19837
      biological role 19835
        antimicrobial agent 18251
          nucleoside antibiotic 347
            coformycins 6
              coformycin 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19867
    subatomic particle 19865
      composite particle 19865
        hadron 19865
          baryon 19865
            nucleon 19865
              atomic nucleus 19865
                atom 19865
                  main group element atom 19803
                    p-block element atom 19803
                      carbon group element atom 19744
                        carbon atom 19740
                          organic molecular entity 19740
                            heteroorganic entity 19512
                              organochalcogen compound 19273
                                organooxygen compound 19189
                                  carbohydrates and carbohydrate derivatives 15289
                                    carbohydrate 15289
                                      carbohydrate derivative 14304
                                        glycosyl compound 13067
                                          N-glycosyl compound 5876
                                            coformycins 6
                                              coformycin 6
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