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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:benzoate
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Accession:CHEBI:16150 term browser browse the term
Definition:The simplest member of the class of benzoates that is the conjugate base of benzoic acid, comprising a benzoic acid core with a proton missing to give a charge of -1.
Synonyms:related_synonym: Benzenecarboxylate;   Benzeneformate;   Benzenemethanoate;   Formula=C7H5O2;   InChI=1S/C7H6O2/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H,8,9)/p-1;   InChIKey=WPYMKLBDIGXBTP-UHFFFAOYSA-M;   Phenylcarboxylate;   Phenylformate;   SMILES=[O-]C(=O)c1ccccc1;   benzoate anion;   benzoic acid, ion(1-)
 alt_id: CHEBI:13879;   CHEBI:22717
 xref: CAS:766-76-7;   Gmelin:2945;   HMDB:HMDB0001870;   KEGG:C00180;   MetaCyc:BENZOATE;   Reaxys:1862486;   UM-BBD_compID:c0121
 cyclic_relationship: is_conjugate_base_of CHEBI:30746


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3,4-dihydroxybenzoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Epas1 endothelial PAS domain protein 1 increases expression
multiple interactions		 ISO 3,4-dihydroxybenzoate results in increased expression of EPAS1 mRNA
[3,4-dihydroxybenzoate co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of EPAS1 mRNA		 CTD PMID:19679656 NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression
multiple interactions
affects localization		 ISO
EXP		 3,4-dihydroxybenzoate results in increased expression of HIF1A mRNA
[3,4-dihydroxybenzoate co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HIF1A mRNA
[3,4-dihydroxybenzoate co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine metabolite] affects the localization of HIF1A protein
3,4-dihydroxybenzoate affects the localization of HIF1A protein		 CTD PMID:19679656 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 ISO [3,4-dihydroxybenzoate co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HMOX1 mRNA; [3,4-dihydroxybenzoate co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HMOX1 protein
3,4-dihydroxybenzoate results in increased expression of HMOX1 mRNA; 3,4-dihydroxybenzoate results in increased expression of HMOX1 protein		 CTD PMID:19679656 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Slc40a1 solute carrier family 40 member 1 multiple interactions ISO 3,4-dihydroxybenzoate inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC40A1 protein] CTD PMID:19679656 NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression		 ISO [3,4-dihydroxybenzoate co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SOD2 protein
3,4-dihydroxybenzoate results in increased expression of SOD2 protein		 CTD PMID:19679656 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
sodium benzoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
increases activity		 EXP Ascorbic Acid inhibits the reaction [Sodium Benzoate results in increased activity of ACHE protein] CTD PMID:35187746 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO Sodium Benzoate inhibits the reaction [[DAO protein results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA] CTD PMID:19860415 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions EXP Sodium Benzoate promotes the reaction [Cocaine results in increased phosphorylation of and results in increased activity of CAMK2A protein] CTD PMID:17609678 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases expression		 ISO
EXP		 Sodium Benzoate inhibits the reaction [Asbestos, Amosite results in increased activity of CASP3 protein]
Sodium Benzoate results in increased activity of CASP3 protein
Ascorbic Acid inhibits the reaction [Sodium Benzoate results in increased expression of CASP3 protein]		 CTD PMID:11329530 PMID:32911041 PMID:35187746 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO Sodium Benzoate inhibits the reaction [Asbestos, Amosite results in increased activity of CASP9 protein] CTD PMID:12540492 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase decreases activity
multiple interactions		 EXP Sodium Benzoate results in decreased activity of CAT protein
Ascorbic Acid inhibits the reaction [Sodium Benzoate results in decreased activity of CAT protein]		 CTD PMID:32911041 PMID:35187746 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Sodium Benzoate inhibits the reaction [[DAO protein results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA] CTD PMID:19860415 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Dao D-amino-acid oxidase multiple interactions
decreases activity		 ISO
EXP		 Sodium Benzoate inhibits the reaction [[DAO protein results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA]
Sodium Benzoate results in decreased activity of DAO protein		 CTD PMID:19860415 PMID:20952482 NCBI chr12:42,592,342...42,613,046
Ensembl chr12:42,592,343...42,612,741 		JBrowse link
G Esr1 estrogen receptor 1 decreases activity ISO Sodium Benzoate results in decreased activity of ESR1 protein CTD PMID:22562034 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Fshb follicle stimulating hormone subunit beta increases expression EXP Sodium Benzoate results in increased expression of FSHB protein CTD PMID:32911041 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Ifng interferon gamma multiple interactions ISO
EXP		 Sodium Benzoate inhibits the reaction [Lipopolysaccharides results in increased secretion of IFNG protein]
[Food Preservatives results in increased abundance of Sodium Benzoate] which results in increased expression of IFNG mRNA		 CTD PMID:26706697 PMID:32179172 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP [Food Preservatives results in increased abundance of Sodium Benzoate] which results in increased expression of IL10 mRNA CTD PMID:32179172 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP [Food Preservatives results in increased abundance of Sodium Benzoate] which results in increased expression of IL1B mRNA CTD PMID:32179172 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression		 ISO
EXP		 Sodium Benzoate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
[Food Preservatives results in increased abundance of Sodium Benzoate] which results in increased expression of IL6 mRNA
Sodium Benzoate results in increased expression of IL6 protein		 CTD PMID:26706697 PMID:32179172 PMID:32911041 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Lhb luteinizing hormone subunit beta increases expression EXP Sodium Benzoate results in increased expression of LHB protein CTD PMID:32911041 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Msr1 macrophage scavenger receptor 1 multiple interactions ISO Sodium Benzoate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MSR1 mRNA alternative form]; Sodium Benzoate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MSR1 mRNA] CTD PMID:9614211 NCBI chr16:52,717,775...52,803,602
Ensembl chr16:52,717,732...52,799,676 		JBrowse link
G Otc ornithine transcarbamylase multiple interactions ISO Sodium Benzoate affects the reaction [OTC gene mutant form affects the abundance of Hydroxyindoleacetic Acid]; Sodium Benzoate affects the reaction [OTC gene mutant form affects the metabolism of Glycine]; Sodium Benzoate affects the reaction [OTC gene mutant form affects the metabolism of Serotonin]; Sodium Benzoate affects the reaction [OTC gene mutant form results in increased abundance of Ammonium Compounds] CTD PMID:3091026 PMID:3374991 NCBI chr  X:12,453,834...12,529,954
Ensembl chr  X:12,453,834...12,566,918 		JBrowse link
G Tfam transcription factor A, mitochondrial increases expression EXP Sodium Benzoate results in increased expression of TFAM protein CTD PMID:32911041 NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 ISO
EXP		 Sodium Benzoate inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
[Food Preservatives results in increased abundance of Sodium Benzoate] which results in increased expression of TNF mRNA; Ascorbic Acid inhibits the reaction [Sodium Benzoate results in increased expression of TNF protein]		 CTD PMID:26706697 PMID:32179172 PMID:32911041 PMID:35187746 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression		 ISO
EXP		 Sodium Benzoate inhibits the reaction [Asbestos, Amosite results in increased expression of TP53 mRNA]
Sodium Benzoate results in increased expression of TP53 protein		 CTD PMID:16357363 PMID:32911041 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Ucp2 uncoupling protein 2 increases expression EXP Sodium Benzoate results in increased expression of UCP2 protein CTD PMID:32911041 NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611 		JBrowse link
G Xdh xanthine dehydrogenase increases activity EXP Sodium Benzoate results in increased activity of XDH protein CTD PMID:32911041 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      biological role 19848
        biochemical role 19556
          metabolite 19544
            eukaryotic metabolite 19368
              plant metabolite 17985
                benzoate 27
                  2,3-dihydroxybenzoate 0
                  2,3-dimethylbenzoate 0
                  2,4,6-trimethylbenzoate 0
                  2,4-dichlorobenzoate 0
                  2,4-dimethylbenzoate 0
                  2,5-dimethylbenzoate 0
                  2,6-dichlorobenzoate 0
                  2,6-dimethylbenzoate 0
                  2-diazoniobenzoate + 0
                  2-halobenzoate + 0
                  2-nitrobenzoate 0
                  3,4-dihydroxybenzoate 5
                  3,4-dimethylbenzoate 0
                  3,5-dibromo-4-hydroxybenzoate 0
                  3,5-dichloro-4-hydroxybenzoate 0
                  3,5-dimethylbenzoate 0
                  3-bromo-4-hydroxybenzoate 0
                  3-chlorobenzoate 0
                  3-diazoniobenzoate + 0
                  3-ethoxybenzoate 0
                  3-fluorobenzoate + 0
                  3-hydroxybenzoate + 0
                  4-aminobenzoate + 0
                  4-bromobenzoate + 0
                  4-chlorobenzoate + 0
                  4-diazoniobenzoate + 0
                  4-fluorobenzoate + 0
                  4-hydroxy-3-octaprenylbenzoate 0
                  4-hydroxybenzoate + 0
                  4-iodobenzoate + 0
                  4-methoxybenzoate + 0
                  4-nitrobenzoate 0
                  4-sulfonatobenzoate(2-) 0
                  cloperastine fendizoate 0
                  macrophomate 0
                  p-mercuribenzoate 0
                  sodium benzoate + 22
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            organic ion 11443
                              organic anion 6849
                                carboxylic acid anion 2494
                                  monocarboxylic acid anion 1605
                                    benzoates 1281
                                      benzoate 27
                                        2,3-dihydroxybenzoate 0
                                        2,3-dimethylbenzoate 0
                                        2,4,6-trimethylbenzoate 0
                                        2,4-dichlorobenzoate 0
                                        2,4-dimethylbenzoate 0
                                        2,5-dimethylbenzoate 0
                                        2,6-dichlorobenzoate 0
                                        2,6-dimethylbenzoate 0
                                        2-diazoniobenzoate + 0
                                        2-halobenzoate + 0
                                        2-nitrobenzoate 0
                                        3,4-dihydroxybenzoate 5
                                        3,4-dimethylbenzoate 0
                                        3,5-dibromo-4-hydroxybenzoate 0
                                        3,5-dichloro-4-hydroxybenzoate 0
                                        3,5-dimethylbenzoate 0
                                        3-bromo-4-hydroxybenzoate 0
                                        3-chlorobenzoate 0
                                        3-diazoniobenzoate + 0
                                        3-ethoxybenzoate 0
                                        3-fluorobenzoate + 0
                                        3-hydroxybenzoate + 0
                                        4-aminobenzoate + 0
                                        4-bromobenzoate + 0
                                        4-chlorobenzoate + 0
                                        4-diazoniobenzoate + 0
                                        4-fluorobenzoate + 0
                                        4-hydroxy-3-octaprenylbenzoate 0
                                        4-hydroxybenzoate + 0
                                        4-iodobenzoate + 0
                                        4-methoxybenzoate + 0
                                        4-nitrobenzoate 0
                                        4-sulfonatobenzoate(2-) 0
                                        cloperastine fendizoate 0
                                        macrophomate 0
                                        p-mercuribenzoate 0
                                        sodium benzoate + 22
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