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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:indole-3-acetamide
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Accession:CHEBI:16031 term browser browse the term
Definition:A member of the class of indoles that is acetamide substituted by a 1H-indol-3-yl group at position 2. It is an intermediate in the production of plant hormone indole acetic acid (IAA).
Synonyms:exact_synonym: 2-(1H-indol-3-yl)acetamide
 related_synonym: 1H-indole-3-acetamide;   3-indoleacetamide;   Formula=C10H10N2O;   InChI=1S/C10H10N2O/c11-10(13)5-7-6-12-9-4-2-1-3-8(7)9/h1-4,6,12H,5H2,(H2,11,13);   InChIKey=ZOAMBXDOGPRZLP-UHFFFAOYSA-N;   SMILES=NC(=O)Cc1c[nH]c2ccccc12;   indoleacetamide
 alt_id: CHEBI:14446;   CHEBI:24800;   CHEBI:46118;   CHEBI:5904
 xref: CAS:879-37-8;   HMDB:HMDB0029739;   KEGG:C02693;   KNApSAcK:C00000108
 xref_mesh: MESH:C015950
 xref: MetaCyc:CPD-237;   PDBeChem:TSR;   PMID:22079545;   PMID:22210218;   PMID:22447967;   PMID:23306880;   PMID:23521653;   PMID:24350783;   Reaxys:143368


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indole-3-acetamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression
multiple interactions 		ISO indoleacetamide results in increased expression of ABCB1 mRNA
indoleacetamide promotes the reaction [NR1I2 protein binds to ABCB1 promoter]; NR1I2 protein promotes the reaction [indoleacetamide results in increased expression of ABCB1 mRNA] 		CTD PMID:33002526 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
multiple interactions 		ISO indoleacetamide results in increased expression of CYP3A4 mRNA
NR1I2 protein promotes the reaction [indoleacetamide results in increased expression of CYP3A4 mRNA] 		CTD PMID:33002526 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO indoleacetamide binds to and results in increased activity of NR1I2 protein; indoleacetamide promotes the reaction [NR1I2 protein binds to ABCB1 promoter]; NR1I2 protein promotes the reaction [indoleacetamide results in increased expression of ABCB1 mRNA]; NR1I2 protein promotes the reaction [indoleacetamide results in increased expression of CYP3A4 mRNA] CTD PMID:33002526 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20871
    role 20829
      biological role 20827
        biochemical role 20274
          metabolite 20255
            eukaryotic metabolite 19969
              plant metabolite 18270
                indole-3-acetamide 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 20871
    subatomic particle 20869
      composite particle 20869
        hadron 20869
          baryon 20869
            nucleon 20869
              atomic nucleus 20869
                atom 20869
                  main group element atom 20792
                    p-block element atom 20792
                      carbon group element atom 20725
                        carbon atom 20721
                          organic molecular entity 20721
                            heteroorganic entity 20226
                              organochalcogen compound 19911
                                organooxygen compound 19814
                                  carbon oxoacid 19160
                                    carboxylic acid 19157
                                      carboacyl group 18080
                                        univalent carboacyl group 18080
                                          carbamoyl group 17916
                                            carboxamide 17916
                                              acetamides 14864
                                                acetamide 8919
                                                  indole-3-acetamide 3
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