CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: dihydroxyacetone
Accession: CHEBI:16016
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Definition: A ketotriose consisting of acetone bearing hydroxy substituents at positions 1 and 3. The simplest member of the class of ketoses and the parent of the class of glycerones.
Synonyms: related_synonym: 1,3-Dihydroxy-2-propanone; 1,3-Dihydroxyacetone; 1,3-Dihydroxydimethyl ketone; 1,3-Dihydroxypropan-2-one; 1,3-Dihydroxypropanone; 1,3-propanediol-2-one; Bis(hydroxymethyl) ketone; DHA; Formula=C3H6O3; Glycerone; InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2; InChIKey=RXKJFZQQPQGTFL-UHFFFAOYSA-N; SMILES=C(CO)(CO)=O; alpha,alpha'-dihydroxyacetone
alt_id: CHEBI:14340; CHEBI:24354; CHEBI:39809; CHEBI:5453
xref: Beilstein:1740268; CAS:96-26-4; DrugBank:DB01775; HMDB:HMDB0001882; KEGG:C00184; KEGG:D07841
xref_mesh: MESH:D004098
xref: MetaCyc:DIHYDROXYACETONE; PDBeChem:2HA; PMID:20936361; PMID:21549029; PMID:21598406; PMID:23543734; PMID:23554234; PMID:23748086; PMID:24209782; Reaxys:1740268; Wikipedia:Dihydroxyacetone
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Atm
ATM serine/threonine kinase
decreases expression
ISO
Dihydroxyacetone results in decreased expression of ATM mRNA
CTD
PMID:32506039
NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
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Casp3
caspase 3
increases cleavage
ISO
Dihydroxyacetone results in increased cleavage of CASP3 protein
CTD
PMID:29193605
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Ccl21
C-C motif chemokine ligand 21
decreases expression
ISO
Dihydroxyacetone results in decreased expression of CCL21 mRNA
CTD
PMID:32506039
NCBI chr 5:56,980,557...56,981,661
Ensembl chr 5:56,980,558...56,981,686
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Ccl3
C-C motif chemokine ligand 3
decreases expression
ISO
Dihydroxyacetone results in decreased expression of CCL3 mRNA
CTD
PMID:32506039
NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
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Ccl4
C-C motif chemokine ligand 4
decreases expression
ISO
Dihydroxyacetone results in decreased expression of CCL4 mRNA
CTD
PMID:32506039
NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231
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Ccnc
cyclin C
increases expression
ISO
Dihydroxyacetone results in increased expression of CCNC mRNA
CTD
PMID:32506039
NCBI chr 5:35,266,828...35,284,943
Ensembl chr 5:35,266,823...35,296,584
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
decreases expression
ISO
Dihydroxyacetone results in decreased expression of CDKN1A mRNA
CTD
PMID:32506039
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Cel
carboxyl ester lipase
increases expression
ISO
Dihydroxyacetone results in increased expression of CEL protein
CTD
PMID:32506039
NCBI chr 3:11,883,532...11,891,035
Ensembl chr 3:11,883,532...11,891,035
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Chek2
checkpoint kinase 2
decreases expression
ISO
Dihydroxyacetone results in decreased expression of CHEK2 mRNA
CTD
PMID:32506039
NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
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Cryab
crystallin, alpha B
increases expression
ISO
Dihydroxyacetone results in increased expression of CRYAB mRNA; Dihydroxyacetone results in increased expression of CRYAB protein
CTD
PMID:32506039
NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157
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Csf2
colony stimulating factor 2
increases expression
ISO
Dihydroxyacetone results in increased expression of CSF2 mRNA
CTD
PMID:32506039
NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
decreases expression
ISO
Dihydroxyacetone results in decreased expression of CYP1A1 mRNA
CTD
PMID:32506039
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
decreases expression
ISO
Dihydroxyacetone results in decreased expression of CYP2E1 mRNA
CTD
PMID:32506039
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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Cyp7a1
cytochrome P450 family 7 subfamily A member 1
decreases expression
ISO
Dihydroxyacetone results in decreased expression of CYP7A1 mRNA
CTD
PMID:32506039
NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
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Ddit3
DNA-damage inducible transcript 3
increases expression
ISO
Dihydroxyacetone results in increased expression of DDIT3 mRNA
CTD
PMID:32506039
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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Dnajb4
DnaJ heat shock protein family (Hsp40) member B4
increases expression
ISO
Dihydroxyacetone results in increased expression of DNAJB4 mRNA
CTD
PMID:32506039
NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089
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E2f1
E2F transcription factor 1
increases expression
ISO
Dihydroxyacetone results in increased expression of E2F1 mRNA
CTD
PMID:32506039
NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
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Egr1
early growth response 1
affects expression
ISO
Dihydroxyacetone affects the expression of EGR1 mRNA
CTD
PMID:32506039
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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Eif2s1
eukaryotic translation initiation factor 2 subunit alpha
increases phosphorylation
ISO
Dihydroxyacetone results in increased phosphorylation of EIF2S1 protein
CTD
PMID:32506039
NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
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Ephx2
epoxide hydrolase 2
decreases expression
ISO
Dihydroxyacetone results in decreased expression of EPHX2 mRNA
CTD
PMID:32506039
NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
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Ercc3
ERCC excision repair 3, TFIIH core complex helicase subunit
increases expression
ISO
Dihydroxyacetone results in increased expression of ERCC3 mRNA
CTD
PMID:32506039
NCBI chr18:23,883,613...23,914,326
Ensembl chr18:23,883,580...23,914,329
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Faslg
Fas ligand
affects expression
ISO
Dihydroxyacetone affects the expression of FASLG mRNA
CTD
PMID:32506039
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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Fmo1
flavin containing dimethylaniline monoxygenase 1
decreases expression
ISO
Dihydroxyacetone results in decreased expression of FMO1 mRNA
CTD
PMID:32506039
NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647
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Gdf15
growth differentiation factor 15
decreases expression
ISO
Dihydroxyacetone results in decreased expression of GDF15 mRNA
CTD
PMID:32506039
NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055
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Glo1
glyoxalase 1
affects response to substance
ISO
GLO1 protein affects the susceptibility to Dihydroxyacetone
CTD
PMID:32506039
NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649
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Gpd2
glycerol-3-phosphate dehydrogenase 2
multiple interactions
ISO
GPD2 protein inhibits the reaction [Dihydroxyacetone results in increased abundance of alpha-glycerophosphoric acid]; GPD2 protein inhibits the reaction [Dihydroxyacetone results in increased abundance of Glucose-6-Phosphate]
CTD
PMID:31974165
NCBI chr 3:41,800,552...41,937,729
Ensembl chr 3:41,801,930...41,936,901
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H2ax
H2A.X variant histone
increases expression
ISO
Dihydroxyacetone results in increased expression of H2AX protein
CTD
PMID:32506039
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
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Hmox1
heme oxygenase 1
increases expression
ISO
Dihydroxyacetone results in increased expression of HMOX1 mRNA; Dihydroxyacetone results in increased expression of HMOX1 protein
CTD
PMID:32506039
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Hspa1a
heat shock protein family A (Hsp70) member 1A
increases expression
ISO
Dihydroxyacetone results in increased expression of HSPA1A mRNA
CTD
PMID:32506039
NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
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Hspa2
heat shock protein family A (Hsp70) member 2
increases expression
ISO
Dihydroxyacetone results in increased expression of HSPA2 mRNA
CTD
PMID:32506039
NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287
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Hspa6l-ps1
heat shock protein family A (Hsp70) member 6 like, pseudogene 1
increases expression
ISO
Dihydroxyacetone results in increased expression of HSPA6 protein
CTD
PMID:32506039
NCBI chr13:83,273,176...83,274,317
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Hspb1
heat shock protein family B (small) member 1
increases phosphorylation
ISO
Dihydroxyacetone results in increased phosphorylation of HSPB1 protein
CTD
PMID:32506039
NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
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Hspd1
heat shock protein family D (Hsp60) member 1
increases expression
ISO
Dihydroxyacetone results in increased expression of HSPD1 mRNA
CTD
PMID:32506039
NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
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Hspe1
heat shock protein family E (Hsp10) member 1
increases expression
ISO
Dihydroxyacetone results in increased expression of HSPE1 mRNA
CTD
PMID:32506039
NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089
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Il6
interleukin 6
increases expression
ISO
Dihydroxyacetone results in increased expression of IL6 mRNA
CTD
PMID:32506039
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Mapk1
mitogen activated protein kinase 1
increases phosphorylation
ISO
Dihydroxyacetone results in increased phosphorylation of MAPK1 protein
CTD
PMID:32506039
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
increases phosphorylation
ISO
Dihydroxyacetone results in increased phosphorylation of MAPK3 protein
CTD
PMID:32506039
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Mmp10
matrix metallopeptidase 10
decreases secretion
ISO
Dihydroxyacetone results in decreased secretion of MMP10 protein
CTD
PMID:30959092
NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748
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Mmp13
matrix metallopeptidase 13
decreases secretion
ISO
Dihydroxyacetone results in decreased secretion of MMP13 protein
CTD
PMID:30959092
NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
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Mt2A
metallothionein 2A
decreases expression
ISO
Dihydroxyacetone results in decreased expression of MT2A mRNA
CTD
PMID:32506039
NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
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Muc5ac
mucin 5AC, oligomeric mucus/gel-forming
decreases secretion
ISO
Dihydroxyacetone results in decreased secretion of MUC5AC protein
CTD
PMID:30959092
NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475
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Nfe2l2
NFE2 like bZIP transcription factor 2
increases expression
ISO
Dihydroxyacetone results in increased expression of NFE2L2 protein
CTD
PMID:32506039
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nfkb1
nuclear factor kappa B subunit 1
decreases expression
ISO
Dihydroxyacetone results in decreased expression of NFKB1 mRNA
CTD
PMID:32506039
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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Nos2
nitric oxide synthase 2
decreases expression
ISO
Dihydroxyacetone results in decreased expression of NOS2 mRNA
CTD
PMID:32506039
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Oat
ornithine aminotransferase
multiple interactions
EXP
Dihydroxyacetone inhibits the reaction [Cyclic AMP results in increased activity of OAT protein]
CTD
PMID:2827574
NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682
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Parp1
poly (ADP-ribose) polymerase 1
increases cleavage
ISO
Dihydroxyacetone results in increased cleavage of PARP1 protein
CTD
PMID:29193605 PMID:38867704
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Pcna
proliferating cell nuclear antigen
increases expression
ISO
Dihydroxyacetone results in increased expression of PCNA mRNA
CTD
PMID:32506039
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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Pklr
pyruvate kinase L/R
multiple interactions
EXP
4-hydroxy-3-(4-(2-hydroxyphenyl)phenyl)-6-oxo-7H-thieno(2,3-b)pyridine-5-carbonitrile inhibits the reaction [Dihydroxyacetone results in increased expression of PKLR mRNA]
CTD
PMID:31974165
NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870
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Prkaa1
protein kinase AMP-activated catalytic subunit alpha 1
multiple interactions
ISO
[[PRKAA1 gene mutant form co-treated with PRKAA2 gene mutant form] affects the susceptibility to [Dihydroxyacetone co-treated with S 4048]] which results in decreased abundance of Adenosine Triphosphate; [PRKAA1 gene mutant form co-treated with PRKAA2 gene mutant form] affects the susceptibility to [Dihydroxyacetone co-treated with S 4048]
CTD
PMID:31974165
NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
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Prkaa2
protein kinase AMP-activated catalytic subunit alpha 2
multiple interactions
ISO
[[PRKAA1 gene mutant form co-treated with PRKAA2 gene mutant form] affects the susceptibility to [Dihydroxyacetone co-treated with S 4048]] which results in decreased abundance of Adenosine Triphosphate; [PRKAA1 gene mutant form co-treated with PRKAA2 gene mutant form] affects the susceptibility to [Dihydroxyacetone co-treated with S 4048]
CTD
PMID:31974165
NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543
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Tnf
tumor necrosis factor
increases expression
ISO
Dihydroxyacetone results in increased expression of TNF mRNA
CTD
PMID:32506039
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnfrsf1a
TNF receptor superfamily member 1A
affects expression
ISO
Dihydroxyacetone affects the expression of TNFRSF1A mRNA
CTD
PMID:32506039
NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
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Tnfsf10
TNF superfamily member 10
decreases expression
ISO
Dihydroxyacetone results in decreased expression of TNFSF10 mRNA
CTD
PMID:32506039
NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
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Ung
uracil-DNA glycosylase
decreases expression
ISO
Dihydroxyacetone results in decreased expression of UNG mRNA
CTD
PMID:32506039
NCBI chr12:42,485,276...42,494,217
Ensembl chr12:42,485,276...42,494,206
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Xrcc2
X-ray repair cross complementing 2
increases expression
ISO
Dihydroxyacetone results in increased expression of XRCC2 mRNA; Dihydroxyacetone results in increased expression of XRCC2 protein
CTD
PMID:32506039
NCBI chr 4:9,423,873...9,502,980
Ensembl chr 4:9,423,898...9,442,482
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Idh2
isocitrate dehydrogenase (NADP(+)) 2
increases abundance multiple interactions
ISO
IDH2 protein mutant form results in increased abundance of Dihydroxyacetone Phosphate Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Dihydroxyacetone Phosphate]
CTD
PMID:27469509
NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
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Tpi1
triosephosphate isomerase 1
affects metabolic processing
EXP
TPI1 protein affects the metabolism of Dihydroxyacetone Phosphate
CTD
PMID:14762718
NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541
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