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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:5-oxoproline
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Accession:CHEBI:16010 term browser browse the term
Definition:An oxoproline having the oxo group placed at the 5-position. It is an intermediate metabolite in the glutathione cycle.
Synonyms:exact_synonym: 5-oxopyrrolidine-2-carboxylic acid
 related_synonym: 5-Pyrrolidone-2-carboxylic acid;   5-oxo-DL-proline;   Formula=C5H7NO3;   Glp;   InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9);   InChIKey=ODHCTXKNWHHXJC-UHFFFAOYSA-N;   Pyroglutamate;   Pyroglutamic acid;   SMILES=OC(=O)C1CCC(=O)N1
 alt_id: CHEBI:12157;   CHEBI:20624;   CHEBI:2116;   CHEBI:44943
 xref: Beilstein:82131;   CAS:149-87-1;   PMID:17439666;   PMID:22770225;   PMID:23217740;   Reaxys:82131;   Wikipedia:Pyroglutamic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:57606


show annotations for term's descendants           Sort by:
5-oxo-L-proline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dek DEK proto-oncogene multiple interactions ISO DEK protein results in decreased chemical synthesis of and results in increased uptake of Pyrrolidonecarboxylic Acid CTD PMID:28558019 NCBI chr17:17,580,804...17,602,825
Ensembl chr17:17,580,843...17,602,808 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO [1-Methyl-3-isobutylxanthine co-treated with butylbenzyl phthalate co-treated with INS protein] results in increased abundance of Pyrrolidonecarboxylic Acid analog CTD PMID:26820058 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      biological role 19852
        biochemical role 19582
          metabolite 19562
            eukaryotic metabolite 19390
              animal metabolite 19256
                mammalian metabolite 19255
                  human metabolite 18771
                    5-oxoproline 2
                      5-oxo-D-proline 0
                      5-oxo-L-proline + 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    p-block element atom 19849
                      carbon group element atom 19766
                        carbon atom 19785
                          organic molecular entity 19785
                            heteroorganic entity 19541
                              organochalcogen compound 19301
                                organooxygen compound 19193
                                  carbon oxoacid 18681
                                    carboxylic acid 18678
                                      carboacyl group 17728
                                        univalent carboacyl group 17728
                                          carbamoyl group 17548
                                            carboxamide 17580
                                              lactam 8393
                                                gamma-lactam 6643
                                                  pyrrolidin-2-ones 168
                                                    5-oxoproline 2
                                                      5-oxo-D-proline 0
                                                      5-oxo-L-proline + 2
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