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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:L-histidine
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Accession:CHEBI:15971 term browser browse the term
Definition:The L-enantiomer of the amino acid histidine.
Synonyms:exact_synonym: (2S)-2-amino-3-(1H-imidazol-4-yl)propanoic acid
 related_synonym: (S)-4-(2-Amino-2-carboxyethyl)imidazole;   (S)-alpha-Amino-1H-imidazole-4-propionic acid;   (S)-alpha-amino-1H-Imidazole-4-propanoic acid;   Formula=C6H9N3O2;   H;   HISTIDINE;   His;   InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1;   InChIKey=HNDVDQJCIGZPNO-YFKPBYRVSA-N;   L-Histidin;   SMILES=N[C@@H](Cc1c[nH]cn1)C(O)=O
 alt_id: CHEBI:13117;   CHEBI:21324;   CHEBI:43048;   CHEBI:43114;   CHEBI:43190;   CHEBI:43239;   CHEBI:6240
 xref: Beilstein:84088;   CAS:71-00-1;   DrugBank:DB00117;   ECMDB:ECMDB00177;   Gmelin:83042;   HMDB:HMDB0000177;   KEGG:C00135;   KEGG:D00032;   KNApSAcK:C00001363
 xref_mesh: MESH:D006639
 xref: MetaCyc:HIS;   PDBeChem:HIS;   PMID:15206581;   PMID:21608102;   PMID:21719207;   PMID:22324399;   PMID:22415677;   PMID:22517640;   Reaxys:84088;   Wikipedia:L-histidine;   YMDB:YMDB00369
 cyclic_relationship: is_conjugate_acid_of CHEBI:32510;   is_conjugate_base_of CHEBI:32513;   is_enantiomer_of CHEBI:27947;   is_tautomer_of CHEBI:57595


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L-histidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions
decreases abundance		 ISO [APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of Histidine; PF-06840003 inhibits the reaction [[APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of Histidine]
APP protein mutant form results in decreased abundance of Histidine
PF-06840003 inhibits the reaction [APP protein mutant form results in decreased abundance of Histidine]		 CTD PMID:39172838 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Hdc histidine decarboxylase multiple interactions ISO [HDC protein binds to Pyridoxal Phosphate] which binds to and results in increased metabolism of Histidine CTD PMID:35151785 NCBI chr 3:113,847,256...113,865,334
Ensembl chr 3:113,847,260...113,865,341 		JBrowse link
G Psen1 presenilin 1 multiple interactions ISO [APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of Histidine; PF-06840003 inhibits the reaction [[APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of Histidine] CTD PMID:39172838 NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650 		JBrowse link
ergothioneine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions ISO Ergothioneine inhibits the reaction [Cisplatin results in decreased activity of ACHE protein] CTD PMID:20932872 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased phosphorylation of AKT1 protein] CTD PMID:33580994 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased activity of CASP3 protein] CTD PMID:33580994 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions EXP Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased activity of CAT protein] CTD PMID:33580994 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of FOS protein] CTD PMID:33580994 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased activity of GPT protein] CTD PMID:33580994 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of IL6 protein] CTD PMID:33580994 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha multiple interactions EXP Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of PIK3CA protein] CTD PMID:33580994 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which affects the localization of RELA protein] CTD PMID:33580994 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Slc22a4 solute carrier family 22 member 4 multiple interactions ISO Ergothioneine inhibits the reaction [SLC22A4 protein results in increased abundance of and results in increased localization of Doxorubicin]
Ergothioneine inhibits the reaction [SLC22A4 protein results in increased abundance of Doxorubicin]		 CTD PMID:37453608 NCBI chr10:38,133,333...38,179,932
Ensembl chr10:38,133,322...38,179,720 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TNF protein] CTD PMID:33580994 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      biological role 19852
        biochemical role 19582
          metabolite 19562
            histidine 14
              L-histidine 14
                Ala-Gly-His 0
                Ala-Leu-Leu-His 0
                Ala-Val-Asp-His 0
                Asn-Gly-Pro-His 0
                Asn-His 0
                Asn-Lys-His-His 0
                Asn-Trp-Cys-His 0
                Asp-His 0
                Cys-Cys-His-His 0
                Cys-Met-Phe-His 0
                Gly-His 0
                His-His 0
                His-Ile 0
                His-Phe 0
                Ile-His 0
                L-histidine derivative + 11
                L-histidine residue + 0
                L-histidyl group 0
                Leu-Asn-His 0
                N(2)-L-histidino group 0
                N(alpha)-(L-gamma-glutamyl)-hercynyl-L-cysteine sulfoxide 0
                N(alpha)-(L-gamma-glutamyl)-hercynyl-L-selenocysteine 0
                N(pros)-L-histidino group 0
                N(tele)-L-histidino group 0
                Phe-His 0
                Ser-His 0
                Thr-Ala-His 0
                Thr-His 0
                Tyr-His 0
                Val-His 0
                alpha-methyl-L-histidine 0
                cyclo(L-His-L-Pro) 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    main group molecular entity 19849
                      s-block molecular entity 19681
                        hydrogen molecular entity 19662
                          hydrides 19167
                            inorganic hydride 18182
                              pnictogen hydride 18172
                                nitrogen hydride 18085
                                  azane 17866
                                    ammonia 17865
                                      organic amino compound 17888
                                        amino acid 16071
                                          alpha-amino acid 13929
                                            L-alpha-amino acid 12971
                                              L-histidine 14
                                                Ala-Gly-His 0
                                                Ala-Leu-Leu-His 0
                                                Ala-Val-Asp-His 0
                                                Asn-Gly-Pro-His 0
                                                Asn-His 0
                                                Asn-Lys-His-His 0
                                                Asn-Trp-Cys-His 0
                                                Asp-His 0
                                                Cys-Cys-His-His 0
                                                Cys-Met-Phe-His 0
                                                Gly-His 0
                                                His-His 0
                                                His-Ile 0
                                                His-Phe 0
                                                Ile-His 0
                                                L-histidine derivative + 11
                                                L-histidine residue + 0
                                                L-histidyl group 0
                                                Leu-Asn-His 0
                                                N(2)-L-histidino group 0
                                                N(alpha)-(L-gamma-glutamyl)-hercynyl-L-cysteine sulfoxide 0
                                                N(alpha)-(L-gamma-glutamyl)-hercynyl-L-selenocysteine 0
                                                N(pros)-L-histidino group 0
                                                N(tele)-L-histidino group 0
                                                Phe-His 0
                                                Ser-His 0
                                                Thr-Ala-His 0
                                                Thr-His 0
                                                Tyr-His 0
                                                Val-His 0
                                                alpha-methyl-L-histidine 0
                                                cyclo(L-His-L-Pro) 0
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