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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:biotin
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Accession:CHEBI:15956 term browser browse the term
Definition:An organic heterobicyclic compound that consists of 2-oxohexahydro-1H-thieno[3,4-d]imidazole having a valeric acid substituent attached to the tetrahydrothiophene ring. The parent of the class of biotins.
Synonyms:exact_synonym: 5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoic acid
 related_synonym: (3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-valeric acid;   5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid;   Coenzyme R;   D-Biotin;   Formula=C10H16N2O3S;   InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/t6-,7-,9-/m0/s1;   InChIKey=YBJHBAHKTGYVGT-ZKWXMUAHSA-N;   SMILES=[H][C@]12CS[C@@H](CCCCC(O)=O)[C@@]1([H])NC(=O)N2;   Vitamin H;   biotina;   biotine;   biotinum;   cis-(+)-Tetrahydro-2-oxothieno[3,4]imidazoline-4-valeric acid;   cis-Hexahydro-2-oxo-1H-thieno(3,4)imidazole-4-valeric acid;   cis-Tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid;   vitamin B7
 alt_id: CHEBI:13905;   CHEBI:22882;   CHEBI:22884;   CHEBI:3108;   CHEBI:41236
 xref: Beilstein:86838;   CAS:58-85-5;   COMe:MOL000144;   Chemspider:149962;   DrugBank:DB00121;   Drug_Central:373;   FooDB:FDB014510;   Gmelin:1918703;   HMDB:HMDB0000030;   KEGG:C00120;   KEGG:D00029;   KNApSAcK:C00000756;   LINCS:LSM-3994
 xref_mesh: MESH:D001710
 xref: MetaCyc:BIOTIN;   PDBeChem:BTN;   PMCID:PMC8089577;   PMID:10064317;   PMID:10215065;   PMID:10577274;   PMID:11435506;   PMID:11481419;   PMID:11800048;   PMID:12055344;   PMID:12070309;   PMID:12603856;   PMID:12803839;   PMID:15012185;   PMID:15202718;   PMID:15272000;   PMID:15690449;   PMID:15863846;   PMID:15899401;   PMID:15992684;   PMID:16011464;   PMID:16195795;   PMID:16419467;   PMID:16676358;   PMID:16677798;   PMID:16704206;   PMID:16769720;   PMID:17297119;   PMID:1814646;   PMID:18202531;   PMID:18452485;   PMID:18509457;   PMID:19212411;   PMID:19319844;   PMID:19727438;   PMID:19928962;   PMID:20967359;   PMID:20974274;   PMID:2100006;   PMID:21248194;   PMID:21356565;   PMID:21373679;   PMID:21596550;   PMID:21871906;   PMID:25515858;   PMID:33346513;   PMID:33461365;   PMID:34077272;   PMID:8333586;   PMID:8750932;   PMID:9022537;   PMID:9038855;   PMID:9094878;   PMID:9164991;   PMID:9176832;   PMID:9371938;   PMID:9416479;   Reaxys:86838;   Wikipedia:Biotin
 cyclic_relationship: is_conjugate_acid_of CHEBI:57586



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biotin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in decreased phosphorylation of AKT1 protein]; [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased cleavage of AKT1 protein]; Biotin inhibits the reaction [Aluminum Chloride results in decreased phosphorylation of AKT1 protein]; Biotin inhibits the reaction [Aluminum Chloride results in increased cleavage of AKT1 protein] CTD PMID:32383521 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G App amyloid beta precursor protein multiple interactions EXP [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of APP protein]; Biotin inhibits the reaction [Aluminum Chloride results in increased expression of APP protein] CTD PMID:32383521 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Ccna2 cyclin A2 increases expression ISO Biotin results in increased expression of CCNA2 mRNA CTD PMID:34699867 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnd3 cyclin D3 increases expression ISO Biotin results in increased expression of CCND3 mRNA CTD PMID:34699867 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
JBrowse link
G Ccne1 cyclin E1 increases expression ISO Biotin results in increased expression of CCNE1 mRNA CTD PMID:34699867 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Cdk2 cyclin dependent kinase 2 increases expression ISO Biotin results in increased expression of CDK2 mRNA CTD PMID:34699867 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk4 cyclin-dependent kinase 4 increases expression ISO Biotin results in increased expression of CDK4 mRNA CTD PMID:34699867 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression ISO Biotin results in decreased expression of CDKN1A mRNA CTD PMID:34699867 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cidea cell death-inducing DFFA-like effector a multiple interactions ISO [acetyl methyl tetramethyl tetralin co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in decreased expression of CIDEA mRNA CTD PMID:34323617 NCBI chr18:60,894,917...60,920,485
Ensembl chr18:60,894,874...60,920,481
JBrowse link
G Cidec cell death-inducing DFFA-like effector c multiple interactions ISO [acetyl methyl tetramethyl tetralin co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in increased expression of CIDEC mRNA; [quinoxyfen co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in increased expression of CIDEC mRNA CTD PMID:34323617 NCBI chr 4:146,569,288...146,582,173
Ensembl chr 4:146,569,289...146,582,173
JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 decreases expression ISO Biotin results in decreased expression of CXCL11 mRNA CTD PMID:15219929 NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,689,424...15,692,271
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
increases expression
ISO Biotin results in increased expression of and results in increased activity of CYP1B1 protein
Biotin results in increased expression of CYP1B1 mRNA
CTD PMID:15219929 PMID:15333708 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO Biotin inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein] CTD PMID:9143349 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G E2f1 E2F transcription factor 1 increases expression ISO Biotin results in increased expression of E2F1 mRNA CTD PMID:34699867 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
JBrowse link
G Hba-a2 hemoglobin alpha, adult chain 2 multiple interactions ISO [Chromium co-treated with Biotin] results in decreased expression of HBA1 protein modified form; [chromium tripicolinate co-treated with Biotin] results in decreased expression of HBA1 protein modified form CTD PMID:17684468 NCBI chr10:15,323,830...15,324,677
Ensembl chr10:15,307,815...15,338,392
JBrowse link
G Herc4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 increases expression ISO Biotin results in increased expression of HERC4 mRNA CTD PMID:15219929 NCBI chr20:25,329,972...25,404,657
Ensembl chr20:25,330,280...25,404,657
JBrowse link
G Hira histone cell cycle regulator decreases expression ISO Biotin results in decreased expression of HIRA mRNA CTD PMID:15219929 NCBI chr11:82,024,469...82,133,212
Ensembl chr11:82,024,469...82,133,529
JBrowse link
G Ighg1 immunoglobulin heavy constant gamma 1 increases expression ISO Biotin results in increased expression of IGHG1 mRNA CTD PMID:15219929 Ensembl chr 6:132,389,370...132,393,397 JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of IL1B protein]; Biotin inhibits the reaction [Aluminum Chloride results in increased expression of IL1B protein] CTD PMID:32383521 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions EXP [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of IL6 protein]; Biotin inhibits the reaction [Aluminum Chloride results in increased expression of IL6 protein] CTD PMID:32383521 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ins1 insulin 1 multiple interactions ISO [acetyl methyl tetramethyl tetralin co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in decreased expression of CIDEA mRNA; [acetyl methyl tetramethyl tetralin co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in decreased expression of SDHA protein; [acetyl methyl tetramethyl tetralin co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in increased expression of CIDEC mRNA; [quinoxyfen co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in decreased expression of SDHA protein; [quinoxyfen co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in increased expression of CIDEC mRNA CTD PMID:34323617 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions EXP [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride affects the phosphorylation of IRS1 protein]; Biotin inhibits the reaction [Aluminum Chloride affects the phosphorylation of IRS1 protein] CTD PMID:32383521 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 decreases expression ISO Biotin results in decreased expression of LAMP1 mRNA CTD PMID:15219929 NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases expression ISO Biotin results in increased expression of MAPK1 protein CTD PMID:34699867 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO Biotin results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Sdha succinate dehydrogenase complex flavoprotein subunit A multiple interactions ISO [acetyl methyl tetramethyl tetralin co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in decreased expression of SDHA protein; [quinoxyfen co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in decreased expression of SDHA protein CTD PMID:34323617 NCBI chr 1:28,935,965...28,960,936
Ensembl chr 1:28,940,164...28,961,535
JBrowse link
G Sele selectin E affects binding ISO [Acetylglucosamine analog binds to Biotin] which binds to SELE protein CTD PMID:12191509 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
JBrowse link
G Sell selectin L affects binding EXP [Acetylglucosamine analog binds to Biotin] which binds to SELL protein CTD PMID:12191509 NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456
JBrowse link
G Selp selectin P affects binding ISO [Acetylglucosamine analog binds to Biotin] which binds to SELP protein CTD PMID:12191509 NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845
JBrowse link
G Slc5a6 solute carrier family 5 member 6 affects expression
increases transport
increases uptake
multiple interactions
ISO
EXP
Biotin affects the expression of SLC5A6 mRNA; Biotin affects the expression of SLC5A6 protein
SLC5A6 protein results in increased transport of Biotin; SLC5A6 results in increased transport of Biotin
SLC5A6 results in increased uptake of Biotin
2,4-Dinitrophenol inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]; 4-Chloromercuribenzenesulfonate inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]; Azides inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]; calmidazolium inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]; chelerythrine inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]; Gramicidin inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]; Iodoacetates inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]; Ouabain inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]; Probenecid inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]; Sodium affects the reaction [SLC5A6 results in increased transport of Biotin]; Sodium promotes the reaction [SLC5A6 protein results in increased transport of Biotin]; Staurosporine inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]; Tetradecanoylphorbol Acetate promotes the reaction [SLC5A6 protein results in increased transport of Biotin]; Trifluoperazine inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]
Sodium affects the reaction [SLC5A6 results in increased transport of Biotin]; Thioctic Acid inhibits the reaction [SLC5A6 results in increased transport of Biotin]
CTD PMID:9516450 PMID:10329687 PMID:10516089 PMID:12646417 PMID:15561972 NCBI chr 6:25,319,187...25,331,713
Ensembl chr 6:25,320,442...25,331,712
JBrowse link
G Sp1 Sp1 transcription factor increases expression ISO Biotin results in increased expression of SP1 mRNA CTD PMID:34699867 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
JBrowse link
G Sp3 Sp3 transcription factor increases expression ISO Biotin results in increased expression of SP3 mRNA CTD PMID:34699867 NCBI chr 3:57,811,855...57,857,150
Ensembl chr 3:57,812,075...57,860,342
JBrowse link
G Tf transferrin multiple interactions ISO [acetyl methyl tetramethyl tetralin co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in decreased expression of CIDEA mRNA; [acetyl methyl tetramethyl tetralin co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in decreased expression of SDHA protein; [acetyl methyl tetramethyl tetralin co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in increased expression of CIDEC mRNA; [quinoxyfen co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in decreased expression of SDHA protein; [quinoxyfen co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in increased expression of CIDEC mRNA CTD PMID:34323617 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
JBrowse link
G Tmprss15 transmembrane serine protease 15 increases expression ISO Biotin results in increased expression of TMPRSS15 mRNA CTD PMID:15219929 NCBI chr11:17,677,741...17,802,255
Ensembl chr11:17,677,741...17,802,255
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of TNF protein]; Biotin inhibits the reaction [Aluminum Chloride results in increased expression of TNF protein] CTD PMID:32383521 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tpr translocated promoter region, nuclear basket protein increases expression ISO Biotin results in increased expression of TPR mRNA CTD PMID:15219929 NCBI chr13:62,424,312...62,487,502
Ensembl chr13:62,424,312...62,487,496
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19922
    role 19894
      biological role 19864
        biochemical role 19596
          cofactor 16592
            biotin 36
              GCB 0
              biocytin + 0
              biotin amide 0
              biotinyl group + 0
              biotinyl-5'-AMP 0
              biotinyl-CoA 0
              vitamin B complex 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19922
    subatomic particle 19892
      composite particle 19892
        hadron 19920
          baryon 19892
            nucleon 19920
              atomic nucleus 19892
                atom 19892
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19805
                        carbon atom 19802
                          organic molecular entity 19775
                            heteroorganic entity 19556
                              organochalcogen compound 19315
                                organooxygen compound 19205
                                  carbon oxoacid 18694
                                    carboxylic acid 18691
                                      carboacyl group 17723
                                        univalent carboacyl group 17723
                                          carbamoyl group 17576
                                            carboxamide 17576
                                              monocarboxylic acid amide 15748
                                                urea 6224
                                                  ureas 6222
                                                    biotins 36
                                                      biotin 36
                                                        GCB 0
                                                        biocytin + 0
                                                        biotin amide 0
                                                        biotinyl group + 0
                                                        biotinyl-5'-AMP 0
                                                        biotinyl-CoA 0
                                                        vitamin B complex 0
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