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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:bromide
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Accession:CHEBI:15858 term browser browse the term
Definition:A monoatomic bromine that has formula Br.
Synonyms:exact_synonym: bromide(1-)
 related_synonym: BROMIDE ION;   Br;   Formula=Br;   InChI=1S/BrH/h1H/p-1;   InChIKey=CPELXLSAUQHCOX-UHFFFAOYSA-M;   SMILES=[Br-];   bromine anion
 alt_id: CHEBI:13918;   CHEBI:3178;   CHEBI:49515
 xref: Beilstein:3587179;   CAS:24959-67-9;   Gmelin:14908;   KEGG:C00720;   KEGG:C01324;   PDBeChem:BR
 cyclic_relationship: is_conjugate_base_of CHEBI:47266



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3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A decreases activity ISO thiazolyl blue results in decreased activity of ABCB1 protein CTD PMID:15451006 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
JBrowse link
G Aco2 aconitase 2, mitochondrial multiple interactions EXP [Calcium results in increased activity of ACO2 protein] which results in increased reduction of thiazolyl blue; [Potassium deficiency results in decreased activity of ACO2 protein] which results in decreased reduction of thiazolyl blue CTD PMID:12548706 NCBI chr15:81,756,664...81,799,338
Ensembl chr15:81,756,510...81,799,334
JBrowse link
G Casp3 caspase 3 increases activity ISO thiazolyl blue results in increased activity of CASP3 protein CTD PMID:22401948 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp8 caspase 8 increases activity ISO thiazolyl blue results in increased activity of CASP8 protein CTD PMID:22401948 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662
JBrowse link
G Nqo2 N-ribosyldihydronicotinamide quinone reductase 2 multiple interactions
increases reduction
ISO resveratrol inhibits the reaction [NQO2 protein results in increased reduction of thiazolyl blue]; Tacrine inhibits the reaction [NQO2 protein results in increased reduction of thiazolyl blue] CTD PMID:29281794 NCBI chr13:34,148,642...34,172,448
Ensembl chr13:34,148,670...34,172,426
JBrowse link
butylscopolamine bromide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 multiple interactions ISO Butylscopolammonium Bromide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375
JBrowse link
NAN 190 hydrobromide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htr1a 5-hydroxytryptamine (serotonin) receptor 1A multiple interactions ISO
EXP
[1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine binds to and results in decreased activity of HTR1A protein] which results in decreased susceptibility to Serotonin
[1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine binds to and results in decreased activity of HTR1A protein] which results in decreased susceptibility to Methamphetamine
CTD PMID:15213358 PMID:15482641 PMID:16528294 NCBI chr13:105,580,040...105,584,630
Ensembl chr13:105,580,147...105,584,630
JBrowse link
pifithrin-alpha hydrobromide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin multiple interactions ISO pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ADM mRNA] CTD PMID:20064835 NCBI chr 7:110,226,864...110,229,027
Ensembl chr 7:110,226,868...110,229,027
JBrowse link
G Agt angiotensinogen multiple interactions ISO pifithrin inhibits the reaction [AGT protein modified form results in increased cleavage of CASP3 protein] CTD PMID:19808082 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445
JBrowse link
G Ahr aryl-hydrocarbon receptor affects localization
multiple interactions
ISO
EXP
pifithrin affects the localization of AHR protein
pifithrin binds to and results in increased activity of AHR protein
CTD PMID:15843497 NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037
JBrowse link
G Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 multiple interactions EXP pifithrin inhibits the reaction [Cisplatin affects the localization of AIFM1 protein] CTD PMID:15983031 NCBI chr  X:47,563,821...47,602,440
Ensembl chr  X:47,563,821...47,602,440
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO [Copper Sulfate co-treated with pifithrin] results in increased phosphorylation of AKT1 protein; [pifithrin co-treated with Paclitaxel] results in decreased phosphorylation of AKT1 protein; pifithrin inhibits the reaction [5-Methoxypsoralen results in decreased phosphorylation of AKT1 protein]; pifithrin inhibits the reaction [di-n-propyldithiocarbamate results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; pifithrin inhibits the reaction [Fingolimod Hydrochloride results in decreased phosphorylation of AKT1 protein]; pifithrin results in increased expression of and results in increased phosphorylation of AKT1 protein CTD PMID:15001399 PMID:18516295 PMID:25939952 PMID:30576070 PMID:32687844 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO pifithrin results in increased expression of APAF1 protein CTD PMID:28483490 NCBI chr10:90,825,173...90,918,688
Ensembl chr10:90,825,173...90,918,632
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO pifithrin inhibits the reaction [APP protein alternative form results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [APP protein alternative form results in increased phosphorylation of TP53 protein] CTD PMID:24567336 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654
JBrowse link
G Atf3 activating transcription factor 3 multiple interactions ISO pifithrin inhibits the reaction [sodium arsenite results in increased expression of ATF3 mRNA] CTD PMID:26148435 NCBI chr 1:190,902,493...190,915,530
Ensembl chr 1:190,902,493...190,950,236
JBrowse link
G Atm ataxia telangiectasia mutated multiple interactions ISO pifithrin inhibits the reaction [Etoposide results in increased phosphorylation of and affects the localization of ATM protein] CTD PMID:26259609 NCBI chr 9:53,348,422...53,448,125
Ensembl chr 9:53,350,449...53,448,040
JBrowse link
G B230217C12Rik RIKEN cDNA B230217C12 gene decreases expression ISO pifithrin results in decreased expression of LASP1NB mRNA CTD PMID:28232485 NCBI chr11:97,731,961...97,734,263
Ensembl chr11:97,731,606...97,734,925
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions ISO pifithrin inhibits the reaction [triptolide results in increased expression of BAK1 protein] CTD PMID:30009776 NCBI chr17:27,238,786...27,247,601
Ensembl chr17:27,238,784...27,247,983
JBrowse link
G Bax BCL2-associated X protein multiple interactions
decreases expression
ISO
EXP
pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased expression of BAX protein]; pifithrin inhibits the reaction [Asbestos, Amosite affects the localization of BAX protein]; pifithrin inhibits the reaction [Cisplatin results in increased expression of BAX protein]; pifithrin inhibits the reaction [CITED2 mutant form promotes the reaction [Cisplatin results in increased expression of BAX protein]]; pifithrin inhibits the reaction [Gentian Violet promotes the reaction [TP53 protein results in increased expression of BAX mRNA]]; pifithrin inhibits the reaction [Particulate Matter affects the localization of BAX protein]; pifithrin inhibits the reaction [Pyrroles analog results in increased expression of BAX protein]; pifithrin inhibits the reaction [Reactive Oxygen Species results in increased expression of BAX protein]; pifithrin inhibits the reaction [Smoke analog results in increased expression of BAX mRNA]; pifithrin inhibits the reaction [Smoke analog results in increased expression of BAX protein]
pifithrin results in decreased expression of BAX protein
pifithrin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BAX protein]; pifithrin inhibits the reaction [Camptothecin results in increased expression of BAX protein]; pifithrin inhibits the reaction [Doxorubicin results in increased expression of BAX protein]; pifithrin inhibits the reaction [Humic Substances results in increased expression of BAX protein]; pifithrin inhibits the reaction [Ropivacaine results in increased expression of BAX mRNA]; pifithrin inhibits the reaction [Ropivacaine results in increased expression of BAX protein]; pifithrin inhibits the reaction [triptolide results in increased expression of BAX protein]
pifithrin inhibits the reaction [Doxorubicin results in increased expression of BAX mRNA]; pifithrin inhibits the reaction [Rotenone results in increased expression of BAX protein]; pifithrin inhibits the reaction [Vehicle Emissions results in increased expression of BAX protein]
CTD PMID:11279278 PMID:12893085 PMID:14766674 PMID:16357363 PMID:16946128 More... NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bbc3 BCL2 binding component 3 decreases expression
multiple interactions
ISO
EXP
pifithrin results in decreased expression of BBC3 mRNA; pifithrin results in decreased expression of BBC3 protein
pifithrin inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [5-Methoxypsoralen results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [Gentian Violet promotes the reaction [TP53 protein results in increased expression of BBC3 mRNA]]; pifithrin inhibits the reaction [Simvastatin results in increased expression of BBC3 mRNA]; pifithrin inhibits the reaction [Simvastatin results in increased expression of BBC3 protein]
pifithrin inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Cisplatin results in increased expression of BBC3 protein]]]
pifithrin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [APP protein alternative form results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [cyanoginosin LR results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased expression of BBC3 protein]
CTD PMID:18364113 PMID:18775851 PMID:19095966 PMID:19475672 PMID:20045437 More... NCBI chr 7:16,042,307...16,052,130
Ensembl chr 7:16,042,318...16,052,130
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO pifithrin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BCL2 protein]; pifithrin inhibits the reaction [Arsenic Trioxide results in increased expression of BCL2 mRNA]; pifithrin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; pifithrin inhibits the reaction [Ropivacaine results in decreased expression of BCL2 mRNA]; pifithrin inhibits the reaction [Ropivacaine results in decreased expression of BCL2 protein]; pifithrin inhibits the reaction [triptolide results in decreased expression of BCL2 protein]
[pifithrin co-treated with Arsenic Trioxide] results in decreased expression of BCL2 protein; [pifithrin co-treated with Paclitaxel] results in increased phosphorylation of BCL2 protein; pifithrin inhibits the reaction [Pyrroles analog results in decreased expression of BCL2 protein]; pifithrin inhibits the reaction [Reactive Oxygen Species results in decreased expression of BCL2 protein]
CTD PMID:17487067 PMID:18516295 PMID:18775851 PMID:26884717 PMID:30009776 More... NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Bcl2l1 BCL2-like 1 multiple interactions EXP
ISO
[Puromycin Aminonucleoside co-treated with pifithrin] results in increased expression of BCL2L1 protein; pifithrin inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Cisplatin results in decreased expression of BCL2L1]]]
pifithrin inhibits the reaction [triptolide results in decreased expression of BCL2L1 protein]
CTD PMID:15987750 PMID:21593185 PMID:30009776 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO pifithrin inhibits the reaction [Silybin results in increased cleavage of BID protein] CTD PMID:16777994 NCBI chr 6:120,870,080...120,894,074
Ensembl chr 6:120,868,891...120,893,814
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO [Topotecan co-treated with pifithrin] results in increased degradation of BIRC5 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[pifithrin co-treated with Topotecan] results in increased degradation of BIRC5 protein] CTD PMID:19812371 NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569
JBrowse link
G Brca1 breast cancer 1, early onset multiple interactions ISO pifithrin inhibits the reaction [Etoposide results in increased expression of and affects the localization of BRCA1 protein] CTD PMID:26259609 NCBI chr11:101,379,587...101,442,808
Ensembl chr11:101,379,590...101,442,781
JBrowse link
G Bub1b BUB1B, mitotic checkpoint serine/threonine kinase multiple interactions ISO pifithrin inhibits the reaction [TP53 protein promotes the reaction [chromium hexavalent ion results in decreased expression of BUB1B protein]] CTD PMID:22886373 NCBI chr 2:118,428,684...118,472,073
Ensembl chr 2:118,428,692...118,472,072
JBrowse link
G C3 complement component 3 multiple interactions ISO pifithrin inhibits the reaction [Isoproterenol results in increased expression of C3 protein] CTD PMID:32924446 NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136
JBrowse link
G Casp12 caspase 12 multiple interactions ISO pifithrin inhibits the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP12 protein] CTD PMID:16687611 NCBI chr 9:5,345,419...5,373,034
Ensembl chr 9:5,345,430...5,373,032
JBrowse link
G Casp2 caspase 2 multiple interactions EXP
ISO
pifithrin inhibits the reaction [Cisplatin results in increased activity of CASP2 protein]
pifithrin inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP2 protein]; pifithrin promotes the reaction [Topotecan results in increased cleavage of CASP2 protein]
pifithrin inhibits the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP2 protein]
CTD PMID:15983031 PMID:16687611 PMID:16777994 PMID:19812371 NCBI chr 6:42,241,942...42,259,442
Ensembl chr 6:42,241,919...42,259,442
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
decreases expression
decreases activity
EXP
ISO
pifithrin inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein]]]; pifithrin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [deoxynivalenol results in increased activity of CASP3 protein]; pifithrin inhibits the reaction [Vehicle Emissions results in increased activity of CASP3 protein]; pifithrin promotes the reaction [2,4-dibromophenol metabolite results in increased expression of CASP3 protein modified form]; pifithrin promotes the reaction [quinone analog results in increased expression of CASP3 protein modified form]; pifithrin promotes the reaction [Topotecan results in increased activity of CASP3 protein]
[pifithrin co-treated with Paclitaxel] results in increased cleavage of and results in increased activity of CASP3 protein; [pifithrin co-treated with thiocholchicine] results in increased cleavage of and results in increased activity of CASP3 protein; [pifithrin co-treated with Vinorelbine] results in increased cleavage of and results in increased activity of CASP3 protein; [pifithrin results in decreased activity of TP53 protein] results in decreased susceptibility to [Oxaliplatin results in increased activity of CASP3 protein]; [pifithrin results in increased susceptibility to Plant Preparations] which results in increased cleavage of CASP3 protein; pifithrin inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in decreased cleavage of CASP3 protein]; pifithrin inhibits the reaction [2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone analog results in decreased expression of CASP3 protein]; pifithrin inhibits the reaction [5-Methoxypsoralen results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [[Oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased activity of CASP3 protein]; pifithrin inhibits the reaction [Mustard Gas results in decreased cleavage of CASP3 protein]; pifithrin inhibits the reaction [PSEN2 protein mutant form promotes the reaction [Staurosporine results in increased activity of CASP3 protein]]; pifithrin inhibits the reaction [Pyrroles analog results in increased expression of CASP3 protein modified form]; pifithrin inhibits the reaction [Reactive Oxygen Species results in increased activity of CASP3 protein]; pifithrin inhibits the reaction [Silicon Dioxide results in increased expression of CASP3 protein modified form]; pifithrin inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP3 protein]; pifithrin promotes the reaction [Etoposide results in increased activity of CASP3 protein]; pifithrin promotes the reaction [Etoposide results in increased cleavage of CASP3 protein]
pifithrin results in increased cleavage of CASP3 protein
pifithrin results in decreased expression of CASP3 protein
pifithrin results in decreased activity of CASP3 protein
pifithrin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [AGT protein modified form results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [cyanoginosin LR results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [Diquat results in increased expression of CASP3 protein modified form]; pifithrin inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP3 protein]; pifithrin inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]; pifithrin inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [Ropivacaine results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [Ropivacaine results in increased expression of CASP3 mRNA]; pifithrin inhibits the reaction [triptolide results in increased cleavage of CASP3 protein]
CTD PMID:12556443 PMID:12665479 PMID:15144874 PMID:15976193 PMID:16687611 More... NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp7 caspase 7 multiple interactions ISO pifithrin promotes the reaction [Etoposide results in increased activity of CASP7 protein]
pifithrin inhibits the reaction [cordycepin results in increased cleavage of CASP7 protein]
CTD PMID:24704558 PMID:26259609 NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776
JBrowse link
G Casp8 caspase 8 multiple interactions ISO pifithrin inhibits the reaction [[Decitabine co-treated with Busulfan] results in increased activity of CASP8 protein]; pifithrin inhibits the reaction [[Oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased activity of CASP8 protein]; pifithrin inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP8 protein]
pifithrin inhibits the reaction [Doxorubicin results in increased activity of CASP8 protein]
CTD PMID:16687611 PMID:16777994 PMID:19728331 PMID:19732952 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662
JBrowse link
G Casp9 caspase 9 multiple interactions ISO
EXP
pifithrin inhibits the reaction [5-Methoxypsoralen results in increased cleavage of CASP9 protein]; pifithrin inhibits the reaction [[Decitabine co-treated with Busulfan] results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [cobaltous chloride results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [nickel chloride results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [Particulate Matter results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [Reactive Oxygen Species results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP9 protein]; pifithrin promotes the reaction [Mustard Gas results in increased cleavage of CASP9 protein]
pifithrin inhibits the reaction [Doxorubicin results in increased activity of CASP9 protein]
pifithrin inhibits the reaction [Asbestos, Amosite results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased cleavage of CASP9 protein]; pifithrin inhibits the reaction [Humic Substances results in increased cleavage of CASP9 protein]; pifithrin inhibits the reaction [Particulate Matter results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [triptolide results in increased expression of CASP9 protein modified form]
CTD PMID:16357363 PMID:16687611 PMID:16777994 PMID:16946128 PMID:18683188 More... NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
JBrowse link
G Ccnb1 cyclin B1 increases expression
multiple interactions
ISO pifithrin results in increased expression of CCNB1 mRNA; pifithrin results in increased expression of CCNB1 protein
[pifithrin co-treated with Paclitaxel] results in increased expression of CCNB1 protein
CTD PMID:16620711 PMID:18516295 NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078
JBrowse link
G Ccng1 cyclin G1 multiple interactions ISO pifithrin inhibits the reaction [Arsenic Trioxide results in increased expression of CCNG1 mRNA] CTD PMID:17487067 NCBI chr11:40,639,379...40,646,044
Ensembl chr11:40,639,379...40,646,138
JBrowse link
G Ccng2 cyclin G2 multiple interactions ISO [pifithrin co-treated with Arsenic Trioxide] results in increased expression of CCNG2 mRNA CTD PMID:35030298 NCBI chr 5:93,415,432...93,424,090
Ensembl chr 5:93,415,116...93,424,090
JBrowse link
G Cdc25a cell division cycle 25A multiple interactions ISO pifithrin inhibits the reaction [sodium arsenite results in decreased expression of CDC25A mRNA] CTD PMID:26148435 NCBI chr 9:109,704,545...109,722,963
Ensembl chr 9:109,704,647...109,722,963
JBrowse link
G Cdc25c cell division cycle 25C multiple interactions ISO [pifithrin co-treated with Paclitaxel] results in increased phosphorylation of CDC25C protein CTD PMID:18516295 NCBI chr18:34,866,046...34,884,644
Ensembl chr18:34,866,046...34,884,586
JBrowse link
G Cdh1 cadherin 1 multiple interactions
decreases expression
ISO pifithrin inhibits the reaction [di-n-propyldithiocarbamate results in increased expression of CDH1 protein]
pifithrin results in decreased expression of CDH1 protein
CTD PMID:32687844 NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878
JBrowse link
G Cdk1 cyclin dependent kinase 1 multiple interactions
increases expression
increases phosphorylation
ISO [pifithrin co-treated with Paclitaxel] results in decreased phosphorylation of CDK1 protein
pifithrin results in increased expression of CDK1 protein
pifithrin results in increased phosphorylation of CDK1 protein
CTD PMID:16620711 PMID:18516295 NCBI chr10:69,170,976...69,188,742
Ensembl chr10:69,170,976...69,188,768
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO pifithrin inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in decreased expression of CDK2 protein] CTD PMID:26451628 NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900
JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A multiple interactions
decreases expression
increases expression
EXP
ISO
pifithrin inhibits the reaction [2,4-dibromophenol metabolite results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [quinone analog results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [Vanadates results in increased activity of CDKN1A protein]; TRP53 protein affects the reaction [pifithrin results in decreased expression of CDKN1A mRNA]
pifithrin results in decreased expression of CDKN1A protein
pifithrin results in increased expression of CDKN1A protein
pifithrin inhibits the reaction [arecoline hydrobromide results in increased expression of CDKN1A mRNA]; pifithrin inhibits the reaction [arecoline hydrobromide results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [Arsenic Trioxide results in increased expression of CDKN1A mRNA]; pifithrin inhibits the reaction [Benzo(a)pyrene results in increased expression of CDKN1A mRNA]; pifithrin inhibits the reaction [Benzo(a)pyrene results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [cyanoginosin LR results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [TP53 protein results in increased expression of CDKN1A protein]
pifithrin inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [5-Methoxypsoralen results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [[Air Pollutants results in increased abundance of Benzo(a)pyrene] which results in increased expression of CDKN1A mRNA]; pifithrin inhibits the reaction [[Air Pollutants results in increased abundance of Benzo(a)pyrene] which results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [Benzo(a)pyrene results in increased expression of CDKN1A mRNA]; pifithrin inhibits the reaction [Decitabine results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [Ellagic Acid promotes the reaction [Quercetin results in increased expression of CDKN1A protein]]; pifithrin inhibits the reaction [Paclitaxel results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [Quercetin results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [Resveratrol results in increased expression of CDKN1A mRNA]; pifithrin results in decreased susceptibility to [1-nitropyrene results in increased expression of CDKN1A protein]
CTD PMID:11889192 PMID:11931974 PMID:12413886 PMID:12893085 PMID:15144874 More... NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions ISO pifithrin inhibits the reaction [Etoposide results in increased phosphorylation of CHEK2 protein] CTD PMID:26259609 NCBI chr 5:110,987,668...111,022,006
Ensembl chr 5:110,987,845...111,022,011
JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 multiple interactions ISO pifithrin inhibits the reaction [CITED2 mutant form promotes the reaction [Cisplatin results in increased expression of BAX protein]]; pifithrin inhibits the reaction [CITED2 mutant form promotes the reaction [Cisplatin results in increased expression of TP53 protein]] CTD PMID:21660965 NCBI chr10:17,598,452...17,601,422
Ensembl chr10:17,598,966...17,601,422
JBrowse link
G Crebbp CREB binding protein multiple interactions ISO pifithrin inhibits the reaction [Camptothecin inhibits the reaction [RELA protein binds to CREBBP protein]]; pifithrin inhibits the reaction [Camptothecin promotes the reaction [TP53 protein binds to CREBBP protein]]; pifithrin promotes the reaction [RELA protein binds to CREBBP protein] CTD PMID:13679428 NCBI chr16:3,899,198...4,031,864
Ensembl chr16:3,899,192...4,031,861
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 multiple interactions ISO pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CXCR4 mRNA] CTD PMID:20064835 NCBI chr 1:128,515,936...128,520,036
Ensembl chr 1:128,515,936...128,520,030
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO pifithrin inhibits the reaction [Doxorubicin affects the localization of CYCS protein] CTD PMID:16687611 NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
decreases activity
EXP
ISO
pifithrin results in increased expression of CYP1A1 mRNA; pifithrin results in increased expression of CYP1A1 protein
pifithrin results in decreased activity of CYP1A1 protein
CTD PMID:15698582 PMID:15843497 PMID:16258175 PMID:22044530 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
decreases activity
ISO pifithrin results in increased expression of CYP1A2 mRNA; pifithrin results in increased expression of CYP1A2 protein
pifithrin results in decreased activity of CYP1A2 protein
CTD PMID:16258175 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression
decreases activity
multiple interactions
ISO
EXP
pifithrin results in increased expression of CYP1B1 mRNA
pifithrin results in decreased activity of CYP1B1 protein
pifithrin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased activity of CYP1B1 protein]
CTD PMID:16258175 PMID:35908932 NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490
JBrowse link
G Ddb2 damage specific DNA binding protein 2 multiple interactions ISO pifithrin inhibits the reaction [benzo(a)pyrene diolepoxide I results in increased expression of DDB2 mRNA]; pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of DDB2 mRNA] CTD PMID:20064835 PMID:27694624 NCBI chr 2:91,041,924...91,067,465
Ensembl chr 2:91,041,917...91,067,327
JBrowse link
G Dusp1 dual specificity phosphatase 1 multiple interactions ISO pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of DUSP1 mRNA] CTD PMID:20064835 NCBI chr17:26,724,565...26,727,446
Ensembl chr17:26,724,564...26,781,102
JBrowse link
G Edn1 endothelin 1 decreases expression
multiple interactions
ISO pifithrin results in decreased expression of EDN1 mRNA
pifithrin inhibits the reaction [[KITLG protein co-treated with EDN1 protein] results in increased phosphorylation of TP53 protein]
CTD PMID:19098008 NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466
JBrowse link
G Ednrb endothelin receptor type B decreases expression ISO pifithrin results in decreased expression of EDNRB mRNA CTD PMID:19098008 NCBI chr14:104,052,055...104,081,764
Ensembl chr14:104,052,061...104,081,838
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO pifithrin inhibits the reaction [Doxorubicin results in increased expression of FAS protein]
pifithrin inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of FAS protein]; pifithrin inhibits the reaction [Doxorubicin results in increased expression of FAS mRNA]; pifithrin inhibits the reaction [Doxorubicin results in increased expression of FAS protein]
CTD PMID:11779855 PMID:16687611 PMID:26451628 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172
JBrowse link
G Fdxr ferredoxin reductase multiple interactions ISO pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FDXR mRNA] CTD PMID:20064835 NCBI chr11:115,158,850...115,167,925
Ensembl chr11:115,158,850...115,167,876
JBrowse link
G Fosb FBJ osteosarcoma oncogene B multiple interactions ISO pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FOSB mRNA] CTD PMID:20064835 NCBI chr 7:19,036,621...19,043,970
Ensembl chr 7:19,036,621...19,043,976
JBrowse link
G Fth1 ferritin heavy polypeptide 1 multiple interactions ISO pifithrin inhibits the reaction [di-n-propyldithiocarbamate results in increased degradation of FTH1 protein] CTD PMID:32687844 NCBI chr19:9,957,964...9,962,475
Ensembl chr19:9,957,962...9,962,462
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha multiple interactions EXP
ISO
pifithrin inhibits the reaction [Excitatory Amino Acid Agents results in increased expression of GADD45A mRNA]
pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of GADD45A mRNA]
CTD PMID:20064835 PMID:20955365 NCBI chr 6:67,012,080...67,014,391
Ensembl chr 6:67,012,080...67,014,441
JBrowse link
G Gdf15 growth differentiation factor 15 multiple interactions ISO pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of GDF15 mRNA] CTD PMID:20064835 NCBI chr 8:71,082,043...71,085,106
Ensembl chr 8:71,082,043...71,085,106
JBrowse link
G Glb1 galactosidase, beta 1 multiple interactions ISO pifithrin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of GLB1 protein] CTD PMID:33737050 NCBI chr 9:114,230,146...114,303,447
Ensembl chr 9:114,230,144...114,303,966
JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions ISO pifithrin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of GPX4 protein] CTD PMID:33737050 NCBI chr10:79,883,000...79,892,273
Ensembl chr10:79,883,000...79,892,273
JBrowse link
G H2ax H2A.X variant histone multiple interactions EXP
ISO
pifithrin promotes the reaction [2,4-dibromophenol metabolite results in increased expression of H2AX protein modified form]; pifithrin promotes the reaction [quinone analog results in increased expression of H2AX protein modified form]
[pifithrin results in decreased phosphorylation of TP53 protein] inhibits the reaction [Oxaliplatin results in increased expression of H2AX protein modified form]; pifithrin inhibits the reaction [Decitabine results in increased phosphorylation of H2AX protein]; pifithrin promotes the reaction [Etoposide results in increased expression of H2AX protein]; pifithrin promotes the reaction [Mustard Gas results in increased phosphorylation of H2AX protein]
CTD PMID:19732952 PMID:19735649 PMID:25448276 PMID:26259609 PMID:33961949 NCBI chr 9:44,246,012...44,247,374
Ensembl chr 9:44,245,991...44,247,374
JBrowse link
G Hc hemolytic complement multiple interactions ISO pifithrin inhibits the reaction [Isoproterenol results in increased expression of C5 protein] CTD PMID:32924446 NCBI chr 2:34,873,341...34,958,518
Ensembl chr 2:34,873,343...34,951,450
JBrowse link
G Ikbkb inhibitor of kappaB kinase beta increases phosphorylation
multiple interactions
ISO pifithrin results in increased phosphorylation of IKBKB protein
pifithrin inhibits the reaction [triptolide results in decreased phosphorylation of IKBKB protein]
CTD PMID:31618665 NCBI chr 8:23,149,228...23,196,605
Ensembl chr 8:23,149,228...23,196,605
JBrowse link
G Jun jun proto-oncogene increases expression EXP pifithrin results in increased expression of JUN protein CTD PMID:16061640 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase decreases expression ISO pifithrin results in decreased expression of KIT mRNA CTD PMID:19098008 NCBI chr 5:75,735,647...75,817,382
Ensembl chr 5:75,735,576...75,817,382
JBrowse link
G Kitl kit ligand decreases expression
multiple interactions
ISO pifithrin results in decreased expression of KITLG mRNA
pifithrin inhibits the reaction [[KITLG protein co-treated with EDN1 protein] results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [KITLG protein results in increased phosphorylation of TP53 protein]
CTD PMID:19098008 NCBI chr10:99,851,477...99,936,278
Ensembl chr10:99,851,492...99,936,278
JBrowse link
G Lasp1 LIM and SH3 protein 1 increases expression ISO pifithrin results in increased expression of LASP1 mRNA CTD PMID:28232485 NCBI chr11:97,689,748...97,729,591
Ensembl chr11:97,689,826...97,729,590
JBrowse link
G Ldha lactate dehydrogenase A multiple interactions ISO pifithrin inhibits the reaction [icaritin results in decreased expression of LDHA mRNA]; pifithrin inhibits the reaction [icaritin results in decreased expression of LDHA protein] CTD PMID:38431053 NCBI chr 7:46,491,698...46,505,051
Ensembl chr 7:46,490,899...46,505,051
JBrowse link
G Lyz2 lysozyme 2 multiple interactions EXP pifithrin inhibits the reaction [Lipopolysaccharides results in increased expression of LYZ2 mRNA] CTD PMID:18550754 NCBI chr10:117,113,446...117,118,177
Ensembl chr10:117,113,236...117,118,226
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
increases expression
increases phosphorylation
ISO
EXP
pifithrin inhibits the reaction [Iron Compounds results in increased expression of MAPK1 protein modified form]
pifithrin results in increased expression of MAPK1 protein modified form
pifithrin inhibits the reaction [dibenzo(a,l)pyrene results in increased phosphorylation of MAPK1 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of MAPK1 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [pifithrin results in increased phosphorylation of MAPK1 protein]; pifithrin promotes the reaction [Doxorubicin results in increased phosphorylation of MAPK1 protein]
CTD PMID:12884365 PMID:16005925 PMID:16687611 PMID:28483490 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk10 mitogen-activated protein kinase 10 multiple interactions ISO pifithrin inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of MAPK10 protein] CTD PMID:16687611 NCBI chr 5:103,056,413...103,359,200
Ensembl chr 5:103,055,814...103,359,200
JBrowse link
G Mapk14 mitogen-activated protein kinase 14 multiple interactions
increases phosphorylation
ISO
EXP
pifithrin inhibits the reaction [dibenzo(a,l)pyrene results in increased phosphorylation of MAPK14 protein]
pifithrin results in increased phosphorylation of MAPK14 protein
CTD PMID:16005925 PMID:16061640 NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
increases expression
increases phosphorylation
ISO
EXP
pifithrin inhibits the reaction [Iron Compounds results in increased expression of MAPK3 protein modified form]
pifithrin results in increased expression of MAPK3 protein modified form
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [pifithrin results in increased phosphorylation of MAPK3 protein]; pifithrin promotes the reaction [Doxorubicin results in increased phosphorylation of MAPK3 protein]
pifithrin inhibits the reaction [dibenzo(a,l)pyrene results in increased phosphorylation of MAPK3 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CTD PMID:12884365 PMID:16005925 PMID:16687611 PMID:28483490 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions
EXP
ISO
pifithrin results in increased phosphorylation of MAPK8 protein
pifithrin inhibits the reaction [Silybin results in increased phosphorylation of MAPK8 protein]
CTD PMID:16061640 PMID:16777994 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO pifithrin inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of MAPK9 protein]
pifithrin inhibits the reaction [Silybin results in increased phosphorylation of MAPK9 protein]
CTD PMID:16687611 PMID:16777994 NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248
JBrowse link
G Mc1r melanocortin 1 receptor decreases expression ISO pifithrin results in decreased expression of MC1R mRNA CTD PMID:19098008 NCBI chr 8:124,133,839...124,137,483
Ensembl chr 8:124,133,846...124,137,483
JBrowse link
G Mdm2 transformed mouse 3T3 cell double minute 2 multiple interactions EXP
ISO
pifithrin inhibits the reaction [Doxorubicin results in increased expression of MDM2 mRNA]; pifithrin inhibits the reaction [Vehicle Emissions results in decreased expression of MDM2 protein]
pifithrin inhibits the reaction [Arsenic Trioxide results in increased expression of MDM2 mRNA]
CTD PMID:14766674 PMID:17487067 PMID:18940243 NCBI chr10:117,524,780...117,546,663
Ensembl chr10:117,524,780...117,546,663
JBrowse link
G Mitf melanogenesis associated transcription factor decreases expression ISO pifithrin results in decreased expression of MITF mRNA; pifithrin results in decreased expression of MITF protein CTD PMID:19098008 NCBI chr 6:97,783,966...97,998,321
Ensembl chr 6:97,784,013...97,998,310
JBrowse link
G Mmp1b matrix metallopeptidase 1b (interstitial collagenase) multiple interactions ISO pifithrin inhibits the reaction [Etoposide results in decreased expression of MMP1 protein] CTD PMID:18557930 NCBI chr 9:7,367,670...7,388,026
Ensembl chr 9:7,368,239...7,388,047
JBrowse link
G Mtor mechanistic target of rapamycin kinase increases expression
multiple interactions
ISO pifithrin results in increased expression of MTOR protein
pifithrin inhibits the reaction [di-n-propyldithiocarbamate results in decreased expression of MTOR protein]
CTD PMID:32687844 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140
JBrowse link
G Ncoa4 nuclear receptor coactivator 4 multiple interactions
decreases expression
ISO pifithrin inhibits the reaction [di-n-propyldithiocarbamate results in increased expression of NCOA4 protein]
pifithrin results in decreased expression of NCOA4 protein
CTD PMID:32687844 NCBI chr14:31,881,884...31,901,210
Ensembl chr14:31,881,822...31,901,812
JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions EXP pifithrin results in increased activity of [NFKB1 protein binds to RELA protein] CTD PMID:16061640 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha increases phosphorylation ISO pifithrin results in increased phosphorylation of NFKBIA protein CTD PMID:31618665 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO pifithrin inhibits the reaction [Benzo(a)pyrene results in increased expression of NOS2 protein] CTD PMID:26086121 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Notch1 notch 1 multiple interactions ISO pifithrin inhibits the reaction [Cadmium Chloride results in increased cleavage of NOTCH1 protein] CTD PMID:25118938 NCBI chr 2:26,347,914...26,393,834
Ensembl chr 2:26,347,915...26,406,675
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions ISO pifithrin inhibits the reaction [cordycepin results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [cyanoginosin LR results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein]
[pifithrin co-treated with Arsenic Trioxide] results in decreased expression of PARP1 protein; [pifithrin co-treated with Arsenic Trioxide] results in increased cleavage of PARP1 protein; [pifithrin results in increased susceptibility to Plant Preparations] which results in increased cleavage of PARP1 protein; pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [[Decitabine co-treated with Busulfan] results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [goniothalamin results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [Silybin results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [Simvastatin results in increased cleavage of PARP1 protein]; pifithrin promotes the reaction [Capsaicin results in increased cleavage of and results in increased activity of PARP1 protein]; pifithrin promotes the reaction [Mustard Gas results in increased cleavage of PARP1 protein]
CTD PMID:16687611 PMID:16777994 PMID:19732952 PMID:20045437 PMID:21810437 More... NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO pifithrin inhibits the reaction [Arsenic Trioxide results in increased expression of PCNA mRNA] CTD PMID:17487067 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234
JBrowse link
G Pidd1 p53 induced death domain protein 1 multiple interactions EXP pifithrin inhibits the reaction [Cisplatin results in increased expression of PIDD1 mRNA] CTD PMID:15983031 NCBI chr 7:141,018,026...141,027,477
Ensembl chr 7:141,018,026...141,023,938
JBrowse link
G Pkm pyruvate kinase, muscle multiple interactions ISO pifithrin inhibits the reaction [icaritin results in decreased expression of PKM mRNA]; pifithrin inhibits the reaction [icaritin results in decreased expression of PKM protein] CTD PMID:38431053 NCBI chr 9:59,563,859...59,586,655
Ensembl chr 9:59,563,651...59,586,658
JBrowse link
G Plk1 polo like kinase 1 multiple interactions ISO [pifithrin co-treated with Paclitaxel] results in increased expression of PLK1 protein CTD PMID:18516295 NCBI chr 7:121,758,658...121,769,107
Ensembl chr 7:121,758,662...121,769,096
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 multiple interactions
decreases expression
ISO pifithrin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PMAIP1 protein]
pifithrin results in decreased expression of PMAIP1 protein
pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased expression of PMAIP1 protein]; pifithrin inhibits the reaction [goniothalamin results in increased expression of PMAIP1 protein]; pifithrin inhibits the reaction [Simvastatin results in increased expression of PMAIP1 mRNA]
CTD PMID:20045437 PMID:21810437 PMID:33031904 PMID:35022897 NCBI chr18:66,591,675...66,598,629
Ensembl chr18:66,591,604...66,598,636
JBrowse link
G Polh polymerase (DNA directed), eta (RAD 30 related) multiple interactions ISO pifithrin inhibits the reaction [benzo(a)pyrene diolepoxide I results in increased expression of POLH mRNA]; pifithrin inhibits the reaction [fotemustine results in increased expression of POLH mRNA]; pifithrin inhibits the reaction [fotemustine results in increased expression of POLH protein]; pifithrin inhibits the reaction [Lomustine results in increased expression of POLH protein] CTD PMID:25125662 PMID:27694624 NCBI chr17:46,482,281...46,513,567
Ensembl chr17:46,482,281...46,513,571
JBrowse link
G Prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit multiple interactions ISO [pifithrin co-treated with Quercetin] results in increased phosphorylation of PRKAA1 protein CTD PMID:24535669 NCBI chr15:5,172,641...5,211,380
Ensembl chr15:5,173,343...5,211,380
JBrowse link
G Prkdc protein kinase, DNA activated, catalytic polypeptide multiple interactions ISO pifithrin inhibits the reaction [Capsaicin results in increased phosphorylation of PRKDC protein] CTD PMID:22226932 NCBI chr16:15,455,698...15,660,103
Ensembl chr16:15,455,730...15,660,099
JBrowse link
G Psen2 presenilin 2 multiple interactions ISO pifithrin inhibits the reaction [PSEN2 protein mutant form promotes the reaction [Staurosporine results in increased activity of CASP3 protein]] CTD PMID:12556443 NCBI chr 1:180,054,569...180,091,030
Ensembl chr 1:180,054,569...180,091,003
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO pifithrin inhibits the reaction [5-Methoxypsoralen results in increased expression of PTEN protein] CTD PMID:30576070 NCBI chr19:32,734,977...32,803,560
Ensembl chr19:32,734,897...32,803,560
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO pifithrin inhibits the reaction [Diquat results in increased expression of PTGS2 protein] CTD PMID:29484840 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Rad51 RAD51 recombinase multiple interactions ISO pifithrin inhibits the reaction [tetrachlorobenzoquinone results in decreased expression of RAD51 protein] CTD PMID:27989139 NCBI chr 2:118,943,295...118,966,554
Ensembl chr 2:118,943,274...118,977,926
JBrowse link
G Raf1 v-raf-leukemia viral oncogene 1 multiple interactions ISO [pifithrin co-treated with Paclitaxel] results in increased phosphorylation of RAF1 protein CTD PMID:18516295 NCBI chr 6:115,595,530...115,653,596
Ensembl chr 6:115,595,028...115,653,596
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO pifithrin inhibits the reaction [Humic Substances results in decreased expression of RB1 protein] CTD PMID:18683188 NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions
increases expression
ISO
EXP
pifithrin inhibits the reaction [Camptothecin inhibits the reaction [RELA protein binds to CREBBP protein]]; pifithrin inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]; pifithrin inhibits the reaction [triptolide results in decreased expression of RELA protein]; pifithrin promotes the reaction [RELA protein binds to CREBBP protein]
pifithrin results in increased expression of RELA protein
pifithrin results in increased activity of [NFKB1 protein binds to RELA protein]
CTD PMID:12665479 PMID:13679428 PMID:16061640 PMID:31618665 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
JBrowse link
G S100a9 S100 calcium binding protein A9 (calgranulin B) multiple interactions ISO pifithrin inhibits the reaction [Isoproterenol results in increased expression of S100A9 protein] CTD PMID:32924446 NCBI chr 3:90,599,937...90,603,028
Ensembl chr 3:90,599,939...90,603,028
JBrowse link
G Sesn1 sestrin 1 multiple interactions ISO pifithrin inhibits the reaction [sodium arsenite results in increased expression of SESN1 mRNA] CTD PMID:26148435 NCBI chr10:41,686,570...41,784,432
Ensembl chr10:41,685,931...41,784,420
JBrowse link
G Sesn2 sestrin 2 multiple interactions EXP
ISO
pifithrin inhibits the reaction [Rotenone results in increased expression of SESN2 protein]
[pifithrin co-treated with Arsenic Trioxide] results in increased expression of SESN2 mRNA; [pifithrin co-treated with Quercetin] results in increased expression of SESN2 protein
CTD PMID:24535669 PMID:26031332 PMID:35030298 NCBI chr 4:132,220,115...132,237,767
Ensembl chr 4:132,219,343...132,237,812
JBrowse link
G Slc2a1 solute carrier family 2 (facilitated glucose transporter), member 1 multiple interactions ISO pifithrin inhibits the reaction [triptolide results in decreased expression of SLC2A1 protein]
pifithrin inhibits the reaction [icaritin results in decreased expression of SLC2A1 mRNA]; pifithrin inhibits the reaction [icaritin results in decreased expression of SLC2A1 protein]
CTD PMID:31618665 PMID:38431053 NCBI chr 4:118,966,001...118,994,527
Ensembl chr 4:118,965,908...118,995,180
JBrowse link
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 multiple interactions ISO pifithrin inhibits the reaction [triptolide results in decreased expression of SLC2A4 protein] CTD PMID:31618665 NCBI chr11:69,833,112...69,839,040
Ensembl chr11:69,833,365...69,839,014
JBrowse link
G Slc7a11 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 multiple interactions ISO pifithrin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SLC7A11 protein] CTD PMID:33737050 NCBI chr 3:50,319,385...50,403,947
Ensembl chr 3:49,846,975...50,398,063
JBrowse link
G Snai1 snail family zinc finger 1 multiple interactions
increases expression
ISO pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SNAI1 mRNA]
pifithrin results in increased expression of SNAI1 protein
CTD PMID:20064835 PMID:32687844 NCBI chr 2:167,380,115...167,384,734
Ensembl chr 2:167,380,115...167,384,734
JBrowse link
G Snai2 snail family zinc finger 2 increases expression ISO pifithrin results in increased expression of SNAI2 protein CTD PMID:32687844 NCBI chr16:14,523,716...14,527,259
Ensembl chr16:14,523,716...14,527,249
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions EXP pifithrin inhibits the reaction [Rosiglitazone results in increased expression of SOD2 protein] CTD PMID:19226370 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
JBrowse link
G Sox30 SRY (sex determining region Y)-box 30 multiple interactions ISO pifithrin inhibits the reaction [SOX30 protein results in increased expression of TP53 mRNA]; pifithrin inhibits the reaction [SOX30 protein results in increased expression of TP53 protein] CTD PMID:25435374 NCBI chr11:45,869,873...45,908,824
Ensembl chr11:45,871,137...45,908,821
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions EXP pifithrin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of STAR protein] CTD PMID:32199951 NCBI chr 8:26,298,502...26,306,010
Ensembl chr 8:26,296,583...26,306,010
JBrowse link
G Synb syncytin b multiple interactions ISO pifithrin inhibits the reaction [Benzo(a)pyrene results in increased expression of ERVFRD-1 mRNA] CTD PMID:24361490 NCBI chr14:69,527,827...69,549,857
Ensembl chr14:69,526,793...69,531,748
JBrowse link
G Tgfa transforming growth factor alpha decreases expression
multiple interactions
ISO pifithrin results in decreased expression of TGFA protein
TP53 protein affects the reaction [pifithrin results in decreased expression of TGFA protein]
CTD PMID:12143041 NCBI chr 6:86,172,020...86,252,726
Ensembl chr 6:86,172,205...86,252,701
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO pifithrin inhibits the reaction [Diquat results in increased expression of TNF protein] CTD PMID:29484840 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Traj18 T cell receptor alpha joining 18 multiple interactions ISO pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of STK17A mRNA] CTD PMID:20064835 NCBI chr14:54,438,234...54,438,299
Ensembl chr14:54,438,234...54,438,299
JBrowse link
G Trp53 transformation related protein 53 decreases expression
decreases activity
multiple interactions
affects expression
decreases phosphorylation
ISO
EXP
pifithrin results in decreased expression of TP53 mRNA; pifithrin results in decreased expression of TP53 protein
pifithrin results in decreased activity of TRP53 protein
[pifithrin co-treated with cobaltous chloride] results in increased expression of and affects the localization of TP53 protein; [pifithrin results in decreased activity of TP53 protein] results in decreased susceptibility to [Oxaliplatin results in increased activity of CASP3 protein]; [pifithrin results in decreased activity of TP53 protein] which results in decreased susceptibility to Oxaliplatin; [pifithrin results in decreased phosphorylation of TP53 protein] inhibits the reaction [Oxaliplatin results in increased expression of H2AX protein modified form]; pifithrin inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of TP53 protein]; pifithrin inhibits the reaction [[Air Pollutants results in increased abundance of Benzo(a)pyrene] which results in increased expression of TP53 mRNA]; pifithrin inhibits the reaction [[KITLG protein co-treated with EDN1 protein] results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Asbestos, Amosite affects the localization of TP53 protein]; pifithrin inhibits the reaction [Asbestos, Amosite results in increased expression of TP53 protein]; pifithrin inhibits the reaction [Benzo(a)pyrene results in increased expression of TP53 protein]; pifithrin inhibits the reaction [Capsaicin results in increased phosphorylation of and results in increased activity of TP53 protein]; pifithrin inhibits the reaction [Celecoxib results in increased expression of TP53 protein]; pifithrin inhibits the reaction [Cisplatin results in increased expression of TP53 protein]; pifithrin inhibits the reaction [CITED2 mutant form promotes the reaction [Cisplatin results in increased expression of TP53 protein]]; pifithrin inhibits the reaction [di-n-propyldithiocarbamate results in increased expression of and results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Ellagic Acid promotes the reaction [Quercetin results in increased phosphorylation of TP53 protein]]; pifithrin inhibits the reaction [Etoposide results in increased activity of TP53 protein]; pifithrin inhibits the reaction [Gentian Violet promotes the reaction [TP53 protein results in increased expression of BAX mRNA]]; pifithrin inhibits the reaction [Gentian Violet promotes the reaction [TP53 protein results in increased expression of BBC3 mRNA]]; pifithrin inhibits the reaction [goniothalamin results in increased phosphorylation of and results in increased expression of TP53 protein]; pifithrin inhibits the reaction [KITLG protein results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [olaquindox results in decreased expression of TP53 protein]; pifithrin inhibits the reaction [Particulate Matter affects the localization of TRP53 protein]; pifithrin inhibits the reaction [Particulate Matter results in increased expression of TRP53 mRNA]; pifithrin inhibits the reaction [Particulate Matter results in increased expression of TRP53 protein]; pifithrin inhibits the reaction [Pyrroles analog results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Quercetin results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Reactive Oxygen Species affects the localization of TP53 protein]; pifithrin inhibits the reaction [Resveratrol results in increased expression of and results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Resveratrol results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Silybin results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Simvastatin results in increased expression of TP53 protein]; pifithrin inhibits the reaction [Smoke analog results in increased expression of TP53 mRNA]; pifithrin inhibits the reaction [SOX30 protein results in increased expression of TP53 mRNA]; pifithrin inhibits the reaction [SOX30 protein results in increased expression of TP53 protein]; pifithrin inhibits the reaction [TP53 protein promotes the reaction [chromium hexavalent ion results in decreased expression of BUB1B protein]]; pifithrin inhibits the reaction [TP53 protein results in increased susceptibility to Resveratrol]; pifithrin inhibits the reaction [TP53 protein results in increased susceptibility to trichostatin A]; pifithrin inhibits the reaction [TP53 results in increased susceptibility to Celecoxib]; pifithrin results in decreased expression of and results in decreased phosphorylation of TP53 protein; pifithrin results in decreased susceptibility to [Oxaliplatin results in increased expression of TP53 protein modified form]; pifithrin results in decreased susceptibility to [Oxaliplatin results in increased expression of TP53 protein]
pifithrin affects the expression of TRP53 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [pifithrin results in increased expression of and results in increased activity of TRP53 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [pifithrin results in increased expression of and results in increased activity of TRP53 protein]; [pifithrin results in decreased activity of TP53 protein] which results in decreased susceptibility to deoxynivalenol; [pifithrin results in decreased activity of TRP53 protein] inhibits the reaction [zearalenol affects the abundance of Reactive Oxygen Species]; [pifithrin results in decreased activity of TRP53 protein] which results in decreased susceptibility to zearalenol; pifithrin inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Cisplatin results in increased acetylation of TRP53 protein]]]; pifithrin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased phosphorylation of TRP53 protein]; pifithrin inhibits the reaction [Cisplatin results in increased acetylation of TRP53 protein]; pifithrin inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased expression of TRP53 protein]; pifithrin inhibits the reaction [deoxynivalenol results in increased phosphorylation of and results in increased activity of TRP53 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased expression of and results in increased phosphorylation of TRP53 protein]; pifithrin inhibits the reaction [Lipopolysaccharides results in increased expression of TRP53 mRNA]; pifithrin inhibits the reaction [Vanadates results in increased activity of TRP53 protein]; pifithrin inhibits the reaction [Vehicle Emissions results in increased phosphorylation of TRP53 protein]; pifithrin results in increased expression of and results in increased phosphorylation of and results in increased activity of TRP53 protein; TRP53 protein affects the reaction [pifithrin results in decreased expression of CDKN1A mRNA]
pifithrin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TP53 protein]; pifithrin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TP53 protein]; pifithrin inhibits the reaction [APP protein alternative form results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Arsenic Trioxide results in increased activity of TP53 protein]; pifithrin inhibits the reaction [Camptothecin promotes the reaction [TP53 protein binds to CREBBP protein]]; pifithrin inhibits the reaction [Camptothecin results in increased activity of TP53 protein]; pifithrin inhibits the reaction [Cisplatin results in increased activity of TP53 protein]; pifithrin inhibits the reaction [cyanoginosin LR results in increased expression of TP53 protein]; pifithrin inhibits the reaction [dibenzo(a,l)pyrene results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Diquat results in increased expression of and affects the localization of TP53 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased expression of and results in increased localization of TP53 protein modified form]; pifithrin inhibits the reaction [Doxorubicin results in increased expression of and results in increased phosphorylation of and results in increased activity of TP53 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased localization of TP53 protein]; pifithrin inhibits the reaction [Isoproterenol results in increased expression of and results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Lipopolysaccharides results in increased localization of TP53 protein]; pifithrin inhibits the reaction [Ropivacaine results in increased expression of TP53 mRNA]; pifithrin inhibits the reaction [Ropivacaine results in increased expression of TP53 protein]; pifithrin inhibits the reaction [TP53 protein results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [TP53 protein results in increased susceptibility to Cisplatin]; pifithrin inhibits the reaction [triptolide results in increased expression of and results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [triptolide results in increased expression of TP53 protein modified form]; pifithrin inhibits the reaction [triptolide results in increased expression of TP53 protein]; pifithrin results in decreased expression of and results in decreased phosphorylation of TP53 protein; TP53 protein affects the reaction [pifithrin results in decreased expression of TGFA protein]
CTD PMID:10702639 PMID:11279278 PMID:11889192 PMID:11914272 PMID:11931974 More... NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
G Trp53bp1 transformation related protein 53 binding protein 1 multiple interactions ISO pifithrin inhibits the reaction [Etoposide results in increased expression of and affects the localization of TP53BP1 protein] CTD PMID:26259609 NCBI chr 2:121,025,316...121,126,830
Ensembl chr 2:121,023,762...121,101,888
JBrowse link
G Tyr tyrosinase decreases expression ISO pifithrin results in decreased expression of TYR mRNA; pifithrin results in decreased expression of TYR protein CTD PMID:19098008 NCBI chr 7:87,073,979...87,142,637
Ensembl chr 7:87,073,979...87,142,720
JBrowse link
G Usp8 ubiquitin specific peptidase 8 multiple interactions ISO pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased expression of BAX protein]; pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased expression of PMAIP1 protein] CTD PMID:35022897 NCBI chr 2:126,549,280...126,601,234
Ensembl chr 2:126,549,248...126,601,217
JBrowse link
G Vim vimentin multiple interactions ISO pifithrin inhibits the reaction [di-n-propyldithiocarbamate results in decreased expression of VIM protein] CTD PMID:32687844 NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637
JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO [Topotecan co-treated with pifithrin] results in increased degradation of XIAP protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[pifithrin co-treated with Topotecan] results in increased degradation of XIAP protein] CTD PMID:19812371 NCBI chr  X:41,148,483...41,198,541
Ensembl chr  X:41,148,556...41,198,533
JBrowse link
G Xpc xeroderma pigmentosum, complementation group C multiple interactions ISO pifithrin inhibits the reaction [benzo(a)pyrene diolepoxide I results in increased expression of XPC mRNA] CTD PMID:27694624 NCBI chr 6:91,466,287...91,492,870
Ensembl chr 6:91,466,287...91,492,870
JBrowse link
sodium bromide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc5a5 solute carrier family 5 (sodium iodide symporter), member 5 multiple interactions ISO sodium bromide inhibits the reaction [SLC5A5 protein results in increased uptake of perrhenate analog]; sodium bromide inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide analog]; sodium bromide inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Pertechnetate Tc 99m] CTD PMID:12488351 NCBI chr 8:71,335,529...71,345,429
Ensembl chr 8:71,335,533...71,345,401
JBrowse link
tiotropium bromide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrm1 cholinergic receptor, muscarinic 1, CNS affects binding ISO Tiotropium Bromide binds to CHRM1 protein CTD PMID:21870878 NCBI chr19:8,641,369...8,660,970
Ensembl chr19:8,641,153...8,660,951
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2, cardiac affects binding ISO Tiotropium Bromide binds to CHRM2 protein CTD PMID:21870878 NCBI chr 6:36,364,928...36,505,573
Ensembl chr 6:36,365,019...36,505,349
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3, cardiac affects binding ISO Tiotropium Bromide binds to CHRM3 protein CTD PMID:21870878 NCBI chr13:9,925,522...10,411,131
Ensembl chr13:9,925,522...10,410,883
JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 affects binding ISO Tiotropium Bromide binds to CHRM4 protein CTD PMID:21870878 NCBI chr 2:91,752,531...91,760,180
Ensembl chr 2:91,757,594...91,759,033
JBrowse link
G Chrm5 cholinergic receptor, muscarinic 5 affects binding ISO Tiotropium Bromide binds to CHRM5 protein CTD PMID:21870878 NCBI chr 2:112,306,055...112,365,487
Ensembl chr 2:112,309,516...112,311,114
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO Tiotropium Bromide inhibits the reaction [Oxotremorine results in increased expression of EDN1 mRNA] CTD PMID:22796455 NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466
JBrowse link
G Pon1 paraoxonase 1 decreases activity ISO Tiotropium Bromide results in decreased activity of PON1 protein CTD PMID:31581362 NCBI chr 6:5,168,101...5,193,824
Ensembl chr 6:5,168,090...5,193,946
JBrowse link
G Tnf tumor necrosis factor decreases secretion ISO Tiotropium Bromide results in decreased secretion of TNF protein CTD PMID:21352583 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
tiquizium bromide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 decreases activity ISO thiaton results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO thiaton inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:11855677 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO thiaton inhibits the reaction [Indomethacin results in increased activity of NOS2 protein] CTD PMID:11855677 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
vecuronium bromide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP-binding cassette, sub-family A member 1 multiple interactions ISO Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCA1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCA1 protein] CTD PMID:30036686 NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 multiple interactions ISO Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCG1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCG1 protein] CTD PMID:30036686 NCBI chr17:31,276,668...31,336,958
Ensembl chr17:31,276,649...31,336,962
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1, CNS multiple interactions ISO Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein] CTD PMID:9846649 NCBI chr19:8,641,369...8,660,970
Ensembl chr19:8,641,153...8,660,951
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2, cardiac multiple interactions ISO Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM2 protein] CTD PMID:9846649 NCBI chr 6:36,364,928...36,505,573
Ensembl chr 6:36,365,019...36,505,349
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3, cardiac multiple interactions ISO Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein] CTD PMID:9846649 NCBI chr13:9,925,522...10,411,131
Ensembl chr13:9,925,522...10,410,883
JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 multiple interactions ISO Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM4 protein] CTD PMID:9846649 NCBI chr 2:91,752,531...91,760,180
Ensembl chr 2:91,757,594...91,759,033
JBrowse link
G Chrm5 cholinergic receptor, muscarinic 5 multiple interactions ISO Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein] CTD PMID:9846649 NCBI chr 2:112,306,055...112,365,487
Ensembl chr 2:112,309,516...112,311,114
JBrowse link
G Chrna3 cholinergic receptor, nicotinic, alpha polypeptide 3 multiple interactions ISO Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]] CTD PMID:16931985 NCBI chr 9:54,917,401...54,933,846
Ensembl chr 9:54,917,395...54,933,846
JBrowse link
G Chrna4 cholinergic receptor, nicotinic, alpha polypeptide 4 multiple interactions ISO Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Vecuronium Bromide results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:14645658 PMID:16931985 NCBI chr 2:180,664,104...180,685,339
Ensembl chr 2:180,660,173...180,685,339
JBrowse link
G Chrna7 cholinergic receptor, nicotinic, alpha polypeptide 7 multiple interactions ISO Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein] CTD PMID:16931985 NCBI chr 7:62,748,440...62,862,274
Ensembl chr 7:62,748,440...62,862,317
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions ISO Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Vecuronium Bromide results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:14645658 PMID:16931985 NCBI chr 3:89,660,755...89,671,939
Ensembl chr 3:89,653,502...89,671,939
JBrowse link
G Chrnb4 cholinergic receptor, nicotinic, beta polypeptide 4 multiple interactions ISO Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]] CTD PMID:16931985 NCBI chr 9:54,935,438...54,956,236
Ensembl chr 9:54,935,438...54,956,063
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions EXP Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP11A1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP11A1 protein] CTD PMID:31846720 NCBI chr 9:57,905,307...57,934,314
Ensembl chr 9:57,913,694...57,934,306
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions ISO Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP19A1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP19A1 protein] CTD PMID:30959089 NCBI chr 9:54,073,221...54,175,448
Ensembl chr 9:54,073,221...54,175,394
JBrowse link
G Egr1 early growth response 1 multiple interactions ISO Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of EGR1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of EGR1 protein] CTD PMID:29486207 NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037
JBrowse link
G Elk1 ELK1, member of ETS oncogene family multiple interactions ISO Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of ELK1 protein] CTD PMID:29486207 NCBI chr  X:20,799,634...20,816,847
Ensembl chr  X:20,799,634...20,816,847
JBrowse link
G Hdac4 histone deacetylase 4 multiple interactions EXP Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 protein] CTD PMID:31846720 NCBI chr 1:91,856,501...92,123,424
Ensembl chr 1:91,856,501...92,123,421
JBrowse link
G Hexb hexosaminidase B increases secretion ISO Vecuronium Bromide results in increased secretion of HEXB protein CTD PMID:19758318 NCBI chr13:97,312,839...97,334,865
Ensembl chr13:97,312,839...97,334,865
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 increases expression
multiple interactions
ISO Vecuronium Bromide results in increased expression of HSD11B2 mRNA; Vecuronium Bromide results in increased expression of HSD11B2 protein
Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 protein]
CTD PMID:29486207 NCBI chr 8:106,245,378...106,250,620
Ensembl chr 8:106,245,387...106,250,620
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein] CTD PMID:29486207 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein] CTD PMID:29486207 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 multiple interactions ISO Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H2 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H2 protein] CTD PMID:30036686 NCBI chr 7:44,199,040...44,204,928
Ensembl chr 7:44,199,040...44,203,375
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions ISO Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H3 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H3 protein] CTD PMID:30036686 NCBI chr 2:91,014,406...91,033,189
Ensembl chr 2:91,014,406...91,033,179
JBrowse link
G Scarb1 scavenger receptor class B, member 1 multiple interactions ISO Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of SCARB1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of SCARB1 protein] CTD PMID:30036686 NCBI chr 5:125,354,151...125,418,082
Ensembl chr 5:125,354,151...125,418,158
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions EXP Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of STAR mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of STAR protein] CTD PMID:31846720 NCBI chr 8:26,298,502...26,306,010
Ensembl chr 8:26,296,583...26,306,010
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22317
    chemical entity 22316
      molecular entity 22312
        elemental molecular entity 18372
          elemental halogen 10044
            elemental bromine 156
              monoatomic bromine 149
                bromide 149
                  bromide salt + 149
Path 2
Term Annotations click to browse term
  CHEBI ontology 22317
    chemical entity 22316
      molecular entity 22312
        elemental molecular entity 18372
          monoatomic entity 17335
            monoatomic ion 17330
              monoatomic anion 9944
                monoatomic monoanion 9944
                  halide anion 9944
                    bromide 149
                      bromide salt + 149
paths to the root