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G |
ABCB1 |
ATP binding cassette subfamily B member 1 |
decreases activity |
EXP |
thiazolyl blue results in decreased activity of ABCB1 protein |
CTD |
PMID:15451006 |
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NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
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G |
ACO2 |
aconitase 2 |
multiple interactions |
ISO |
[Calcium results in increased activity of ACO2 protein] which results in increased reduction of thiazolyl blue; [Potassium deficiency results in decreased activity of ACO2 protein] which results in decreased reduction of thiazolyl blue |
CTD |
PMID:12548706 |
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NCBI chr22:41,469,117...41,528,974
Ensembl chr22:41,447,830...41,529,273
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G |
CASP3 |
caspase 3 |
increases activity |
EXP |
thiazolyl blue results in increased activity of CASP3 protein |
CTD |
PMID:22401948 |
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NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
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G |
CASP8 |
caspase 8 |
increases activity |
EXP |
thiazolyl blue results in increased activity of CASP8 protein |
CTD |
PMID:22401948 |
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NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836
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G |
NQO2 |
N-ribosyldihydronicotinamide:quinone dehydrogenase 2 |
increases reduction multiple interactions |
EXP |
NQO2 protein results in increased reduction of thiazolyl blue resveratrol inhibits the reaction [NQO2 protein results in increased reduction of thiazolyl blue]; Tacrine inhibits the reaction [NQO2 protein results in increased reduction of thiazolyl blue] |
CTD |
PMID:29281794 |
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NCBI chr 6:2,999,894...3,019,755
Ensembl chr 6:2,987,987...3,019,755
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G |
SLC22A2 |
solute carrier family 22 member 2 |
multiple interactions |
EXP |
Butylscopolammonium Bromide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] |
CTD |
PMID:21599003 |
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NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638
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G |
HTR1A |
5-hydroxytryptamine receptor 1A |
multiple interactions |
ISO EXP |
[1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine binds to and results in decreased activity of HTR1A protein] which results in decreased susceptibility to Serotonin [1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine binds to and results in decreased activity of HTR1A protein] which results in decreased susceptibility to Methamphetamine |
CTD |
PMID:15213358 PMID:15482641 PMID:16528294 |
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NCBI chr 5:63,957,874...63,962,445
Ensembl chr 5:63,957,874...63,962,507
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G |
ADM |
adrenomedullin |
multiple interactions |
EXP |
pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ADM mRNA] |
CTD |
PMID:20064835 |
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NCBI chr11:10,305,073...10,307,397
Ensembl chr11:10,305,073...10,307,397
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G |
AGT |
angiotensinogen |
multiple interactions |
ISO |
pifithrin inhibits the reaction [AGT protein modified form results in increased cleavage of CASP3 protein] |
CTD |
PMID:19808082 |
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NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576
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G |
AHR |
aryl hydrocarbon receptor |
affects localization multiple interactions |
EXP ISO |
pifithrin affects the localization of AHR protein pifithrin binds to and results in increased activity of AHR protein |
CTD |
PMID:15843497 |
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NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
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G |
AIFM1 |
apoptosis inducing factor mitochondria associated 1 |
multiple interactions |
ISO |
pifithrin inhibits the reaction [Cisplatin affects the localization of AIFM1 protein] |
CTD |
PMID:15983031 |
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NCBI chr X:130,129,362...130,165,841
Ensembl chr X:130,124,666...130,165,879
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G |
AKT1 |
AKT serine/threonine kinase 1 |
multiple interactions |
EXP |
[Copper Sulfate co-treated with pifithrin] results in increased phosphorylation of AKT1 protein; [pifithrin co-treated with Paclitaxel] results in decreased phosphorylation of AKT1 protein; pifithrin inhibits the reaction [5-Methoxypsoralen results in decreased phosphorylation of AKT1 protein]; pifithrin inhibits the reaction [di-n-propyldithiocarbamate results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; pifithrin inhibits the reaction [Fingolimod Hydrochloride results in decreased phosphorylation of AKT1 protein]; pifithrin results in increased expression of and results in increased phosphorylation of AKT1 protein |
CTD |
PMID:15001399 PMID:18516295 PMID:25939952 PMID:30576070 PMID:32687844 |
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NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759
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G |
APAF1 |
apoptotic peptidase activating factor 1 |
increases expression |
EXP |
pifithrin results in increased expression of APAF1 protein |
CTD |
PMID:28483490 |
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NCBI chr12:98,645,290...98,735,433
Ensembl chr12:98,645,149...98,735,433
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G |
APP |
amyloid beta precursor protein |
multiple interactions |
ISO |
pifithrin inhibits the reaction [APP protein alternative form results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [APP protein alternative form results in increased phosphorylation of TP53 protein] |
CTD |
PMID:24567336 |
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NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128
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G |
ATF3 |
activating transcription factor 3 |
multiple interactions |
EXP |
pifithrin inhibits the reaction [sodium arsenite results in increased expression of ATF3 mRNA] |
CTD |
PMID:26148435 |
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NCBI chr 1:212,565,407...212,620,777
Ensembl chr 1:212,565,334...212,620,777
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G |
ATM |
ATM serine/threonine kinase |
multiple interactions |
EXP |
pifithrin inhibits the reaction [Etoposide results in increased phosphorylation of and affects the localization of ATM protein] |
CTD |
PMID:26259609 |
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NCBI chr11:108,223,067...108,369,102
Ensembl chr11:108,222,804...108,369,102
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G |
BAK1 |
BCL2 antagonist/killer 1 |
multiple interactions |
ISO |
pifithrin inhibits the reaction [triptolide results in increased expression of BAK1 protein] |
CTD |
PMID:30009776 |
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NCBI chr 6:33,572,552...33,580,276
Ensembl chr 6:33,572,547...33,580,293
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G |
BAX |
BCL2 associated X, apoptosis regulator |
decreases expression multiple interactions |
EXP ISO |
pifithrin results in decreased expression of BAX protein pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased expression of BAX protein]; pifithrin inhibits the reaction [Asbestos, Amosite affects the localization of BAX protein]; pifithrin inhibits the reaction [Cisplatin results in increased expression of BAX protein]; pifithrin inhibits the reaction [CITED2 mutant form promotes the reaction [Cisplatin results in increased expression of BAX protein]]; pifithrin inhibits the reaction [Gentian Violet promotes the reaction [TP53 protein results in increased expression of BAX mRNA]]; pifithrin inhibits the reaction [Particulate Matter affects the localization of BAX protein]; pifithrin inhibits the reaction [Pyrroles analog results in increased expression of BAX protein]; pifithrin inhibits the reaction [Reactive Oxygen Species results in increased expression of BAX protein]; pifithrin inhibits the reaction [Smoke analog results in increased expression of BAX mRNA]; pifithrin inhibits the reaction [Smoke analog results in increased expression of BAX protein] pifithrin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BAX protein]; pifithrin inhibits the reaction [Camptothecin results in increased expression of BAX protein]; pifithrin inhibits the reaction [Doxorubicin results in increased expression of BAX protein]; pifithrin inhibits the reaction [Humic Substances results in increased expression of BAX protein]; pifithrin inhibits the reaction [Ropivacaine results in increased expression of BAX mRNA]; pifithrin inhibits the reaction [Ropivacaine results in increased expression of BAX protein]; pifithrin inhibits the reaction [triptolide results in increased expression of BAX protein] pifithrin inhibits the reaction [Doxorubicin results in increased expression of BAX mRNA]; pifithrin inhibits the reaction [Rotenone results in increased expression of BAX protein]; pifithrin inhibits the reaction [Vehicle Emissions results in increased expression of BAX protein] |
CTD |
PMID:11279278 PMID:12893085 PMID:14766674 PMID:16357363 PMID:16946128 PMID:18683188 PMID:18775851 PMID:18940243 PMID:21660965 PMID:23665932 PMID:24535435 PMID:26031332 PMID:26884717 PMID:30009776 PMID:30543781 PMID:33031904 PMID:34091999 PMID:35022897 More...
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NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
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G |
BBC3 |
BCL2 binding component 3 |
multiple interactions decreases expression |
EXP ISO |
pifithrin inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [5-Methoxypsoralen results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [Gentian Violet promotes the reaction [TP53 protein results in increased expression of BBC3 mRNA]]; pifithrin inhibits the reaction [Simvastatin results in increased expression of BBC3 mRNA]; pifithrin inhibits the reaction [Simvastatin results in increased expression of BBC3 protein] pifithrin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [APP protein alternative form results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [cyanoginosin LR results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased expression of BBC3 protein] pifithrin results in decreased expression of BBC3 mRNA; pifithrin results in decreased expression of BBC3 protein pifithrin inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Cisplatin results in increased expression of BBC3 protein]]] |
CTD |
PMID:18364113 PMID:18775851 PMID:19095966 PMID:19475672 PMID:20045437 PMID:21593185 PMID:24535435 PMID:24567336 PMID:30576070 PMID:31157505 PMID:32540572 PMID:33031904 PMID:35022897 More...
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NCBI chr19:47,220,824...47,232,860
Ensembl chr19:47,220,822...47,232,766
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G |
BCL2 |
BCL2 apoptosis regulator |
multiple interactions |
ISO EXP |
pifithrin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BCL2 protein]; pifithrin inhibits the reaction [Arsenic Trioxide results in increased expression of BCL2 mRNA]; pifithrin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; pifithrin inhibits the reaction [Ropivacaine results in decreased expression of BCL2 mRNA]; pifithrin inhibits the reaction [Ropivacaine results in decreased expression of BCL2 protein]; pifithrin inhibits the reaction [triptolide results in decreased expression of BCL2 protein] [pifithrin co-treated with Arsenic Trioxide] results in decreased expression of BCL2 protein; [pifithrin co-treated with Paclitaxel] results in increased phosphorylation of BCL2 protein; pifithrin inhibits the reaction [Pyrroles analog results in decreased expression of BCL2 protein]; pifithrin inhibits the reaction [Reactive Oxygen Species results in decreased expression of BCL2 protein] |
CTD |
PMID:17487067 PMID:18516295 PMID:18775851 PMID:26884717 PMID:30009776 PMID:30543781 PMID:33031904 PMID:34091999 PMID:35030298 More...
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NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
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G |
BCL2L1 |
BCL2 like 1 |
multiple interactions |
ISO |
[Puromycin Aminonucleoside co-treated with pifithrin] results in increased expression of BCL2L1 protein; pifithrin inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Cisplatin results in decreased expression of BCL2L1]]] pifithrin inhibits the reaction [triptolide results in decreased expression of BCL2L1 protein] |
CTD |
PMID:15987750 PMID:21593185 PMID:30009776 |
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NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
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G |
BID |
BH3 interacting domain death agonist |
multiple interactions |
EXP |
pifithrin inhibits the reaction [Silybin results in increased cleavage of BID protein] |
CTD |
PMID:16777994 |
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NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770
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G |
BIRC5 |
baculoviral IAP repeat containing 5 |
multiple interactions |
EXP |
[Topotecan co-treated with pifithrin] results in increased degradation of BIRC5 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[pifithrin co-treated with Topotecan] results in increased degradation of BIRC5 protein] |
CTD |
PMID:19812371 |
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NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636
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G |
BRCA1 |
BRCA1 DNA repair associated |
multiple interactions |
EXP |
pifithrin inhibits the reaction [Etoposide results in increased expression of and affects the localization of BRCA1 protein] |
CTD |
PMID:26259609 |
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NCBI chr17:43,044,295...43,170,327
Ensembl chr17:43,044,295...43,170,245
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G |
BUB1B |
BUB1 mitotic checkpoint serine/threonine kinase B |
multiple interactions |
EXP |
pifithrin inhibits the reaction [TP53 protein promotes the reaction [chromium hexavalent ion results in decreased expression of BUB1B protein]] |
CTD |
PMID:22886373 |
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NCBI chr15:40,161,069...40,221,123
Ensembl chr15:40,161,023...40,221,123
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G |
C3 |
complement C3 |
multiple interactions |
ISO |
pifithrin inhibits the reaction [Isoproterenol results in increased expression of C3 protein] |
CTD |
PMID:32924446 |
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NCBI chr19:6,677,704...6,720,650
Ensembl chr19:6,677,704...6,730,562
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G |
C5 |
complement C5 |
multiple interactions |
ISO |
pifithrin inhibits the reaction [Isoproterenol results in increased expression of C5 protein] |
CTD |
PMID:32924446 |
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NCBI chr 9:120,952,335...121,074,865
Ensembl chr 9:120,932,987...121,075,195
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G |
CASP12 |
caspase 12 (gene/pseudogene) |
multiple interactions |
ISO |
pifithrin inhibits the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP12 protein] |
CTD |
PMID:16687611 |
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NCBI chr11:104,883,286...104,898,460
Ensembl chr11:104,885,718...104,898,670
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G |
CASP2 |
caspase 2 |
multiple interactions |
ISO EXP |
pifithrin inhibits the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP2 protein] pifithrin inhibits the reaction [Cisplatin results in increased activity of CASP2 protein] pifithrin inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP2 protein]; pifithrin promotes the reaction [Topotecan results in increased cleavage of CASP2 protein] |
CTD |
PMID:15983031 PMID:16687611 PMID:16777994 PMID:19812371 |
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NCBI chr 7:143,288,351...143,307,696
Ensembl chr 7:143,288,215...143,307,696
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G |
CASP3 |
caspase 3 |
multiple interactions decreases expression decreases activity increases cleavage |
ISO EXP |
pifithrin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [AGT protein modified form results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [cyanoginosin LR results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [Diquat results in increased expression of CASP3 protein modified form]; pifithrin inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP3 protein]; pifithrin inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]; pifithrin inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [Ropivacaine results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [Ropivacaine results in increased expression of CASP3 mRNA]; pifithrin inhibits the reaction [triptolide results in increased cleavage of CASP3 protein] [pifithrin co-treated with Paclitaxel] results in increased cleavage of and results in increased activity of CASP3 protein; [pifithrin co-treated with thiocholchicine] results in increased cleavage of and results in increased activity of CASP3 protein; [pifithrin co-treated with Vinorelbine] results in increased cleavage of and results in increased activity of CASP3 protein; [pifithrin results in decreased activity of TP53 protein] results in decreased susceptibility to [Oxaliplatin results in increased activity of CASP3 protein]; [pifithrin results in increased susceptibility to Plant Preparations] which results in increased cleavage of CASP3 protein; pifithrin inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in decreased cleavage of CASP3 protein]; pifithrin inhibits the reaction [2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone analog results in decreased expression of CASP3 protein]; pifithrin inhibits the reaction [5-Methoxypsoralen results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [[Oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased activity of CASP3 protein]; pifithrin inhibits the reaction [Mustard Gas results in decreased cleavage of CASP3 protein]; pifithrin inhibits the reaction [PSEN2 protein mutant form promotes the reaction [Staurosporine results in increased activity of CASP3 protein]]; pifithrin inhibits the reaction [Pyrroles analog results in increased expression of CASP3 protein modified form]; pifithrin inhibits the reaction [Reactive Oxygen Species results in increased activity of CASP3 protein]; pifithrin inhibits the reaction [Silicon Dioxide results in increased expression of CASP3 protein modified form]; pifithrin inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP3 protein]; pifithrin promotes the reaction [Etoposide results in increased activity of CASP3 protein]; pifithrin promotes the reaction [Etoposide results in increased cleavage of CASP3 protein] pifithrin results in decreased expression of CASP3 protein pifithrin results in decreased activity of CASP3 protein pifithrin results in increased cleavage of CASP3 protein pifithrin inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein]]]; pifithrin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [deoxynivalenol results in increased activity of CASP3 protein]; pifithrin inhibits the reaction [Vehicle Emissions results in increased activity of CASP3 protein]; pifithrin promotes the reaction [2,4-dibromophenol metabolite results in increased expression of CASP3 protein modified form]; pifithrin promotes the reaction [quinone analog results in increased expression of CASP3 protein modified form]; pifithrin promotes the reaction [Topotecan results in increased activity of CASP3 protein] |
CTD |
PMID:12556443 PMID:12665479 PMID:15144874 PMID:15976193 PMID:16687611 PMID:16777994 PMID:18364113 PMID:18516295 PMID:18775851 PMID:18940243 PMID:19728331 PMID:19808082 PMID:19812371 PMID:20708607 PMID:21593185 PMID:25448276 PMID:26259609 PMID:26451628 PMID:26630137 PMID:26884717 PMID:28483490 PMID:29484840 PMID:29698619 PMID:30009776 PMID:30543781 PMID:30576070 PMID:31082419 PMID:31157505 PMID:32924446 PMID:33031904 PMID:33961949 PMID:34091999 PMID:35908932 More...
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NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
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G |
CASP7 |
caspase 7 |
multiple interactions |
ISO EXP |
pifithrin inhibits the reaction [cordycepin results in increased cleavage of CASP7 protein] pifithrin promotes the reaction [Etoposide results in increased activity of CASP7 protein] |
CTD |
PMID:24704558 PMID:26259609 |
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NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907
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G |
CASP8 |
caspase 8 |
multiple interactions |
EXP ISO |
pifithrin inhibits the reaction [[Decitabine co-treated with Busulfan] results in increased activity of CASP8 protein]; pifithrin inhibits the reaction [[Oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased activity of CASP8 protein]; pifithrin inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP8 protein] pifithrin inhibits the reaction [Doxorubicin results in increased activity of CASP8 protein] |
CTD |
PMID:16687611 PMID:16777994 PMID:19728331 PMID:19732952 |
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NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836
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G |
CASP9 |
caspase 9 |
multiple interactions |
ISO EXP |
pifithrin inhibits the reaction [Asbestos, Amosite results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased cleavage of CASP9 protein]; pifithrin inhibits the reaction [Humic Substances results in increased cleavage of CASP9 protein]; pifithrin inhibits the reaction [Particulate Matter results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [triptolide results in increased expression of CASP9 protein modified form] pifithrin inhibits the reaction [5-Methoxypsoralen results in increased cleavage of CASP9 protein]; pifithrin inhibits the reaction [[Decitabine co-treated with Busulfan] results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [cobaltous chloride results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [nickel chloride results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [Particulate Matter results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [Reactive Oxygen Species results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP9 protein]; pifithrin promotes the reaction [Mustard Gas results in increased cleavage of CASP9 protein] |
CTD |
PMID:16357363 PMID:16687611 PMID:16777994 PMID:16946128 PMID:18683188 PMID:18775851 PMID:19732952 PMID:23380477 PMID:23566959 PMID:25448276 PMID:26884717 PMID:29653124 PMID:30009776 PMID:30576070 More...
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NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
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G |
CCNB1 |
cyclin B1 |
multiple interactions increases expression |
EXP |
[pifithrin co-treated with Paclitaxel] results in increased expression of CCNB1 protein pifithrin results in increased expression of CCNB1 mRNA; pifithrin results in increased expression of CCNB1 protein |
CTD |
PMID:16620711 PMID:18516295 |
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NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245
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G |
CCNG1 |
cyclin G1 |
multiple interactions |
ISO |
pifithrin inhibits the reaction [Arsenic Trioxide results in increased expression of CCNG1 mRNA] |
CTD |
PMID:17487067 |
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NCBI chr 5:163,437,571...163,457,640
Ensembl chr 5:163,437,569...163,448,199
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G |
CCNG2 |
cyclin G2 |
multiple interactions |
EXP |
[pifithrin co-treated with Arsenic Trioxide] results in increased expression of CCNG2 mRNA |
CTD |
PMID:35030298 |
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NCBI chr 4:77,157,207...77,170,060
Ensembl chr 4:77,157,207...77,433,388
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G |
CDC25A |
cell division cycle 25A |
multiple interactions |
EXP |
pifithrin inhibits the reaction [sodium arsenite results in decreased expression of CDC25A mRNA] |
CTD |
PMID:26148435 |
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NCBI chr 3:48,157,146...48,188,417
Ensembl chr 3:48,157,146...48,188,417
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G |
CDC25C |
cell division cycle 25C |
multiple interactions |
EXP |
[pifithrin co-treated with Paclitaxel] results in increased phosphorylation of CDC25C protein |
CTD |
PMID:18516295 |
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NCBI chr 5:138,285,265...138,338,355
Ensembl chr 5:138,285,269...138,338,355
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G |
CDH1 |
cadherin 1 |
multiple interactions decreases expression |
EXP |
pifithrin inhibits the reaction [di-n-propyldithiocarbamate results in increased expression of CDH1 protein] pifithrin results in decreased expression of CDH1 protein |
CTD |
PMID:32687844 |
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NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,537
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G |
CDK1 |
cyclin dependent kinase 1 |
increases expression multiple interactions increases phosphorylation |
EXP |
pifithrin results in increased expression of CDK1 protein [pifithrin co-treated with Paclitaxel] results in decreased phosphorylation of CDK1 protein pifithrin results in increased phosphorylation of CDK1 protein |
CTD |
PMID:16620711 PMID:18516295 |
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NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852
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G |
CDK2 |
cyclin dependent kinase 2 |
multiple interactions |
EXP |
pifithrin inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in decreased expression of CDK2 protein] |
CTD |
PMID:26451628 |
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NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789
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CDKN1A |
cyclin dependent kinase inhibitor 1A |
multiple interactions decreases expression increases expression |
ISO EXP |
pifithrin inhibits the reaction [arecoline hydrobromide results in increased expression of CDKN1A mRNA]; pifithrin inhibits the reaction [arecoline hydrobromide results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [Arsenic Trioxide results in increased expression of CDKN1A mRNA]; pifithrin inhibits the reaction [Benzo(a)pyrene results in increased expression of CDKN1A mRNA]; pifithrin inhibits the reaction [Benzo(a)pyrene results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [cyanoginosin LR results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [TP53 protein results in increased expression of CDKN1A protein] pifithrin results in decreased expression of CDKN1A mRNA pifithrin results in decreased expression of CDKN1A protein pifithrin inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [5-Methoxypsoralen results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [[Air Pollutants results in increased abundance of Benzo(a)pyrene] which results in increased expression of CDKN1A mRNA]; pifithrin inhibits the reaction [[Air Pollutants results in increased abundance of Benzo(a)pyrene] which results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [Benzo(a)pyrene results in increased expression of CDKN1A mRNA]; pifithrin inhibits the reaction [Decitabine results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [Ellagic Acid promotes the reaction [Quercetin results in increased expression of CDKN1A protein]]; pifithrin inhibits the reaction [Paclitaxel results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [Quercetin results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [Resveratrol results in increased expression of CDKN1A mRNA]; pifithrin results in decreased susceptibility to [1-nitropyrene results in increased expression of CDKN1A protein] pifithrin results in increased expression of CDKN1A protein pifithrin inhibits the reaction [2,4-dibromophenol metabolite results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [quinone analog results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [Vanadates results in increased activity of CDKN1A protein]; TRP53 protein affects the reaction [pifithrin results in decreased expression of CDKN1A mRNA] |
CTD |
PMID:11889192 PMID:11931974 PMID:12413886 PMID:12893085 PMID:15144874 PMID:15735102 PMID:17487067 PMID:17997002 PMID:18223691 PMID:18516295 PMID:21887816 PMID:22044530 PMID:24361490 PMID:26086121 PMID:26451628 PMID:30576070 PMID:31157505 PMID:33961949 PMID:35022897 PMID:36982514 More...
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NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,397
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G |
CGB3 |
chorionic gonadotropin subunit beta 3 |
multiple interactions |
EXP |
pifithrin inhibits the reaction [Benzo(a)pyrene results in increased expression of CGB3 mRNA] |
CTD |
PMID:24361490 |
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NCBI chr19:49,022,869...49,024,333
Ensembl chr19:49,022,869...49,024,333
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G |
CHEK2 |
checkpoint kinase 2 |
multiple interactions |
EXP |
pifithrin inhibits the reaction [Etoposide results in increased phosphorylation of CHEK2 protein] |
CTD |
PMID:26259609 |
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NCBI chr22:28,687,743...28,741,834
Ensembl chr22:28,687,743...28,742,422
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G |
CITED2 |
Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 |
multiple interactions |
EXP |
pifithrin inhibits the reaction [CITED2 mutant form promotes the reaction [Cisplatin results in increased expression of BAX protein]]; pifithrin inhibits the reaction [CITED2 mutant form promotes the reaction [Cisplatin results in increased expression of TP53 protein]] |
CTD |
PMID:21660965 |
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NCBI chr 6:139,371,807...139,374,648
Ensembl chr 6:139,371,807...139,374,648
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G |
CREBBP |
CREB binding protein |
multiple interactions |
ISO |
pifithrin inhibits the reaction [Camptothecin inhibits the reaction [RELA protein binds to CREBBP protein]]; pifithrin inhibits the reaction [Camptothecin promotes the reaction [TP53 protein binds to CREBBP protein]]; pifithrin promotes the reaction [RELA protein binds to CREBBP protein] |
CTD |
PMID:13679428 |
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NCBI chr16:3,725,054...3,880,713
Ensembl chr16:3,725,054...3,880,713
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G |
CXCR4 |
C-X-C motif chemokine receptor 4 |
multiple interactions |
EXP |
pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CXCR4 mRNA] |
CTD |
PMID:20064835 |
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NCBI chr 2:136,114,349...136,118,149
Ensembl chr 2:136,114,349...136,119,177
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G |
CYCS |
cytochrome c, somatic |
multiple interactions |
ISO |
pifithrin inhibits the reaction [Doxorubicin affects the localization of CYCS protein] |
CTD |
PMID:16687611 |
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NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
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G |
CYP1A1 |
cytochrome P450 family 1 subfamily A member 1 |
increases expression decreases activity |
ISO EXP |
pifithrin results in increased expression of CYP1A1 mRNA; pifithrin results in increased expression of CYP1A1 protein pifithrin results in decreased activity of CYP1A1 protein |
CTD |
PMID:15698582 PMID:15843497 PMID:16258175 PMID:22044530 |
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NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
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G |
CYP1A2 |
cytochrome P450 family 1 subfamily A member 2 |
decreases activity increases expression |
EXP |
pifithrin results in decreased activity of CYP1A2 protein pifithrin results in increased expression of CYP1A2 mRNA; pifithrin results in increased expression of CYP1A2 protein |
CTD |
PMID:16258175 |
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NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
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G |
CYP1B1 |
cytochrome P450 family 1 subfamily B member 1 |
increases expression decreases activity multiple interactions |
EXP ISO |
pifithrin results in increased expression of CYP1B1 mRNA pifithrin results in decreased activity of CYP1B1 protein pifithrin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased activity of CYP1B1 protein] |
CTD |
PMID:16258175 PMID:35908932 |
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NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902
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G |
DDB2 |
damage specific DNA binding protein 2 |
multiple interactions |
EXP |
pifithrin inhibits the reaction [benzo(a)pyrene diolepoxide I results in increased expression of DDB2 mRNA]; pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of DDB2 mRNA] |
CTD |
PMID:20064835 PMID:27694624 |
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NCBI chr11:47,214,454...47,239,217
Ensembl chr11:47,214,465...47,239,217
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G |
DUSP1 |
dual specificity phosphatase 1 |
multiple interactions |
EXP |
pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of DUSP1 mRNA] |
CTD |
PMID:20064835 |
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NCBI chr 5:172,768,096...172,771,195
Ensembl chr 5:172,768,096...172,771,195
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G |
EDN1 |
endothelin 1 |
decreases expression multiple interactions |
EXP |
pifithrin results in decreased expression of EDN1 mRNA pifithrin inhibits the reaction [[KITLG protein co-treated with EDN1 protein] results in increased phosphorylation of TP53 protein] |
CTD |
PMID:19098008 |
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NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194
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G |
EDNRB |
endothelin receptor type B |
decreases expression |
EXP |
pifithrin results in decreased expression of EDNRB mRNA |
CTD |
PMID:19098008 |
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NCBI chr13:77,895,487...77,975,527
Ensembl chr13:77,895,481...77,975,529
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G |
ERVFRD-1 |
endogenous retrovirus group FRD member 1, envelope |
multiple interactions |
EXP |
pifithrin inhibits the reaction [Benzo(a)pyrene results in increased expression of ERVFRD-1 mRNA] |
CTD |
PMID:24361490 |
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NCBI chr 6:11,102,489...11,111,725
Ensembl chr 6:11,102,324...11,111,845
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G |
FAS |
Fas cell surface death receptor |
multiple interactions |
EXP ISO |
pifithrin inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of FAS protein]; pifithrin inhibits the reaction [Doxorubicin results in increased expression of FAS mRNA]; pifithrin inhibits the reaction [Doxorubicin results in increased expression of FAS protein] |
CTD |
PMID:11779855 PMID:16687611 PMID:26451628 |
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NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605
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G |
FDXR |
ferredoxin reductase |
multiple interactions |
EXP |
pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FDXR mRNA] |
CTD |
PMID:20064835 |
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NCBI chr17:74,862,497...74,872,994
Ensembl chr17:74,862,497...74,873,031
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G |
FOSB |
FosB proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
EXP |
pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FOSB mRNA] |
CTD |
PMID:20064835 |
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NCBI chr19:45,467,996...45,475,179
Ensembl chr19:45,467,995...45,475,179
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G |
FTH1 |
ferritin heavy chain 1 |
multiple interactions |
EXP |
pifithrin inhibits the reaction [di-n-propyldithiocarbamate results in increased degradation of FTH1 protein] |
CTD |
PMID:32687844 |
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NCBI chr11:61,964,285...61,967,634
Ensembl chr11:61,959,718...61,967,634
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G |
GADD45A |
growth arrest and DNA damage inducible alpha |
multiple interactions |
ISO EXP |
pifithrin inhibits the reaction [Excitatory Amino Acid Agents results in increased expression of GADD45A mRNA] pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of GADD45A mRNA] |
CTD |
PMID:20064835 PMID:20955365 |
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NCBI chr 1:67,685,201...67,688,334
Ensembl chr 1:67,685,201...67,688,334
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G |
GDF15 |
growth differentiation factor 15 |
multiple interactions |
EXP |
pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of GDF15 mRNA] |
CTD |
PMID:20064835 |
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NCBI chr19:18,386,158...18,389,176
Ensembl chr19:18,374,731...18,389,176
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G |
GLB1 |
galactosidase beta 1 |
multiple interactions |
ISO |
pifithrin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of GLB1 protein] |
CTD |
PMID:33737050 |
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NCBI chr 3:32,961,108...33,097,146
Ensembl chr 3:32,996,609...33,097,202
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G |
GPX4 |
glutathione peroxidase 4 |
multiple interactions |
ISO |
pifithrin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of GPX4 protein] |
CTD |
PMID:33737050 |
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NCBI chr19:1,103,994...1,106,779
Ensembl chr19:1,103,982...1,106,791
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G |
H2AX |
H2A.X variant histone |
multiple interactions |
EXP ISO |
[pifithrin results in decreased phosphorylation of TP53 protein] inhibits the reaction [Oxaliplatin results in increased expression of H2AX protein modified form]; pifithrin inhibits the reaction [Decitabine results in increased phosphorylation of H2AX protein]; pifithrin promotes the reaction [Etoposide results in increased expression of H2AX protein]; pifithrin promotes the reaction [Mustard Gas results in increased phosphorylation of H2AX protein] pifithrin promotes the reaction [2,4-dibromophenol metabolite results in increased expression of H2AX protein modified form]; pifithrin promotes the reaction [quinone analog results in increased expression of H2AX protein modified form] |
CTD |
PMID:19732952 PMID:19735649 PMID:25448276 PMID:26259609 PMID:33961949 |
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NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,874...119,095,465
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G |
IKBKB |
inhibitor of nuclear factor kappa B kinase subunit beta |
multiple interactions increases phosphorylation |
ISO |
pifithrin inhibits the reaction [triptolide results in decreased phosphorylation of IKBKB protein] pifithrin results in increased phosphorylation of IKBKB protein |
CTD |
PMID:31618665 |
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NCBI chr 8:42,271,302...42,332,460
Ensembl chr 8:42,271,302...42,332,460
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G |
JUN |
Jun proto-oncogene, AP-1 transcription factor subunit |
increases expression |
ISO |
pifithrin results in increased expression of JUN protein |
CTD |
PMID:16061640 |
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NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048
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G |
KIT |
KIT proto-oncogene, receptor tyrosine kinase |
decreases expression |
EXP |
pifithrin results in decreased expression of KIT mRNA |
CTD |
PMID:19098008 |
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NCBI chr 4:54,657,957...54,740,715
Ensembl chr 4:54,657,267...54,740,783
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G |
KITLG |
KIT ligand |
decreases expression multiple interactions |
EXP |
pifithrin results in decreased expression of KITLG mRNA pifithrin inhibits the reaction [[KITLG protein co-treated with EDN1 protein] results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [KITLG protein results in increased phosphorylation of TP53 protein] |
CTD |
PMID:19098008 |
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NCBI chr12:88,492,793...88,580,471
Ensembl chr12:88,492,793...88,580,851
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G |
LASP1 |
LIM and SH3 protein 1 |
increases expression |
EXP |
pifithrin results in increased expression of LASP1 mRNA |
CTD |
PMID:28232485 |
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NCBI chr17:38,870,058...38,921,770
Ensembl chr17:38,869,859...38,921,770
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G |
LASP1NB |
LASP1 neighbor |
decreases expression |
EXP |
pifithrin results in decreased expression of LASP1NB mRNA |
CTD |
PMID:28232485 |
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NCBI chr17:38,925,614...38,929,381
Ensembl chr17:38,925,614...38,929,381
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G |
LDHA |
lactate dehydrogenase A |
multiple interactions |
EXP |
pifithrin inhibits the reaction [icaritin results in decreased expression of LDHA mRNA]; pifithrin inhibits the reaction [icaritin results in decreased expression of LDHA protein] |
CTD |
PMID:38431053 |
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NCBI chr11:18,394,563...18,408,425
Ensembl chr11:18,394,560...18,408,425
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G |
LYZ |
lysozyme |
multiple interactions |
ISO |
pifithrin inhibits the reaction [Lipopolysaccharides results in increased expression of LYZ2 mRNA] |
CTD |
PMID:18550754 |
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NCBI chr12:69,348,381...69,354,234
Ensembl chr12:69,348,381...69,354,234
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G |
MAPK1 |
mitogen-activated protein kinase 1 |
multiple interactions increases phosphorylation increases expression |
ISO EXP |
pifithrin inhibits the reaction [dibenzo(a,l)pyrene results in increased phosphorylation of MAPK1 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of MAPK1 protein] pifithrin results in increased phosphorylation of MAPK1 protein pifithrin inhibits the reaction [Iron Compounds results in increased expression of MAPK1 protein modified form] 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [pifithrin results in increased phosphorylation of MAPK1 protein]; pifithrin promotes the reaction [Doxorubicin results in increased phosphorylation of MAPK1 protein] pifithrin results in increased expression of MAPK1 protein modified form |
CTD |
PMID:12884365 PMID:16005925 PMID:16687611 PMID:28483490 |
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NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
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G |
MAPK10 |
mitogen-activated protein kinase 10 |
multiple interactions |
ISO |
pifithrin inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of MAPK10 protein] |
CTD |
PMID:16687611 |
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NCBI chr 4:86,010,405...86,594,074
Ensembl chr 4:85,990,007...86,594,625
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G |
MAPK14 |
mitogen-activated protein kinase 14 |
increases phosphorylation multiple interactions |
ISO |
pifithrin results in increased phosphorylation of MAPK14 protein pifithrin inhibits the reaction [dibenzo(a,l)pyrene results in increased phosphorylation of MAPK14 protein] |
CTD |
PMID:16005925 PMID:16061640 |
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NCBI chr 6:36,027,808...36,124,214
Ensembl chr 6:36,027,752...36,122,511
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G |
MAPK3 |
mitogen-activated protein kinase 3 |
multiple interactions increases expression increases phosphorylation |
EXP ISO |
pifithrin inhibits the reaction [Iron Compounds results in increased expression of MAPK3 protein modified form] pifithrin inhibits the reaction [dibenzo(a,l)pyrene results in increased phosphorylation of MAPK3 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of MAPK3 protein] 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [pifithrin results in increased phosphorylation of MAPK3 protein]; pifithrin promotes the reaction [Doxorubicin results in increased phosphorylation of MAPK3 protein] pifithrin results in increased expression of MAPK3 protein modified form |
CTD |
PMID:12884365 PMID:16005925 PMID:16687611 PMID:28483490 |
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NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
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G |
MAPK8 |
mitogen-activated protein kinase 8 |
increases phosphorylation multiple interactions |
ISO EXP |
pifithrin results in increased phosphorylation of MAPK8 protein pifithrin inhibits the reaction [Silybin results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:16061640 PMID:16777994 |
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NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360
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G |
MAPK9 |
mitogen-activated protein kinase 9 |
multiple interactions |
ISO EXP |
pifithrin inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of MAPK9 protein] pifithrin inhibits the reaction [Silybin results in increased phosphorylation of MAPK9 protein] |
CTD |
PMID:16687611 PMID:16777994 |
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NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099
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G |
MC1R |
melanocortin 1 receptor |
decreases expression |
EXP |
pifithrin results in decreased expression of MC1R mRNA |
CTD |
PMID:19098008 |
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NCBI chr16:89,918,862...89,920,972
Ensembl chr16:89,912,119...89,920,973
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G |
MDM2 |
MDM2 proto-oncogene |
multiple interactions |
ISO |
pifithrin inhibits the reaction [Doxorubicin results in increased expression of MDM2 mRNA]; pifithrin inhibits the reaction [Vehicle Emissions results in decreased expression of MDM2 protein] pifithrin inhibits the reaction [Arsenic Trioxide results in increased expression of MDM2 mRNA] |
CTD |
PMID:14766674 PMID:17487067 PMID:18940243 |
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NCBI chr12:68,808,172...68,850,686
Ensembl chr12:68,808,177...68,845,544
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G |
MITF |
melanocyte inducing transcription factor |
decreases expression |
EXP |
pifithrin results in decreased expression of MITF mRNA; pifithrin results in decreased expression of MITF protein |
CTD |
PMID:19098008 |
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NCBI chr 3:69,739,464...69,968,332
Ensembl chr 3:69,739,456...69,968,336
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G |
MMP1 |
matrix metallopeptidase 1 |
multiple interactions |
EXP |
pifithrin inhibits the reaction [Etoposide results in decreased expression of MMP1 protein] |
CTD |
PMID:18557930 |
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NCBI chr11:102,789,919...102,798,160
Ensembl chr11:102,789,401...102,798,160
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G |
MTOR |
mechanistic target of rapamycin kinase |
increases expression multiple interactions |
EXP |
pifithrin results in increased expression of MTOR protein pifithrin inhibits the reaction [di-n-propyldithiocarbamate results in decreased expression of MTOR protein] |
CTD |
PMID:32687844 |
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NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556
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G |
NCOA4 |
nuclear receptor coactivator 4 |
multiple interactions decreases expression |
EXP |
pifithrin inhibits the reaction [di-n-propyldithiocarbamate results in increased expression of NCOA4 protein] pifithrin results in decreased expression of NCOA4 protein |
CTD |
PMID:32687844 |
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NCBI chr10:46,005,088...46,030,623
Ensembl chr10:46,005,088...46,030,623
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G |
NFKB1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO |
pifithrin results in increased activity of [NFKB1 protein binds to RELA protein] |
CTD |
PMID:16061640 |
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NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302
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G |
NFKBIA |
NFKB inhibitor alpha |
increases phosphorylation |
ISO |
pifithrin results in increased phosphorylation of NFKBIA protein |
CTD |
PMID:31618665 |
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NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749
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G |
NOS2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
pifithrin inhibits the reaction [Benzo(a)pyrene results in increased expression of NOS2 protein] |
CTD |
PMID:26086121 |
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NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
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G |
NOTCH1 |
notch receptor 1 |
multiple interactions |
EXP |
pifithrin inhibits the reaction [Cadmium Chloride results in increased cleavage of NOTCH1 protein] |
CTD |
PMID:25118938 |
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NCBI chr 9:136,494,433...136,546,048
Ensembl chr 9:136,494,433...136,546,048
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G |
PARP1 |
poly(ADP-ribose) polymerase 1 |
multiple interactions |
ISO EXP |
pifithrin inhibits the reaction [cordycepin results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [cyanoginosin LR results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein] [pifithrin co-treated with Arsenic Trioxide] results in decreased expression of PARP1 protein; [pifithrin co-treated with Arsenic Trioxide] results in increased cleavage of PARP1 protein; [pifithrin results in increased susceptibility to Plant Preparations] which results in increased cleavage of PARP1 protein; pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [[Decitabine co-treated with Busulfan] results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [goniothalamin results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [Silybin results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [Simvastatin results in increased cleavage of PARP1 protein]; pifithrin promotes the reaction [Capsaicin results in increased cleavage of and results in increased activity of PARP1 protein]; pifithrin promotes the reaction [Mustard Gas results in increased cleavage of PARP1 protein] |
CTD |
PMID:16687611 PMID:16777994 PMID:19732952 PMID:20045437 PMID:21810437 PMID:22226932 PMID:24704558 PMID:25448276 PMID:25939952 PMID:29698619 PMID:31157505 PMID:35022897 PMID:35030298 More...
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NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154
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G |
PCNA |
proliferating cell nuclear antigen |
multiple interactions |
ISO |
pifithrin inhibits the reaction [Arsenic Trioxide results in increased expression of PCNA mRNA] |
CTD |
PMID:17487067 |
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NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626
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G |
PIDD1 |
p53-induced death domain protein 1 |
multiple interactions |
ISO |
pifithrin inhibits the reaction [Cisplatin results in increased expression of PIDD1 mRNA] |
CTD |
PMID:15983031 |
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NCBI chr11:799,184...809,501
Ensembl chr11:799,179...809,753
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G |
PKM |
pyruvate kinase M1/2 |
multiple interactions |
EXP |
pifithrin inhibits the reaction [icaritin results in decreased expression of PKM mRNA]; pifithrin inhibits the reaction [icaritin results in decreased expression of PKM protein] |
CTD |
PMID:38431053 |
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NCBI chr15:72,199,029...72,231,591
Ensembl chr15:72,199,029...72,231,819
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G |
PLK1 |
polo like kinase 1 |
multiple interactions |
EXP |
[pifithrin co-treated with Paclitaxel] results in increased expression of PLK1 protein |
CTD |
PMID:18516295 |
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NCBI chr16:23,678,889...23,690,367
Ensembl chr16:23,677,656...23,690,367
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G |
PMAIP1 |
phorbol-12-myristate-13-acetate-induced protein 1 |
multiple interactions decreases expression |
EXP ISO |
pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased expression of PMAIP1 protein]; pifithrin inhibits the reaction [goniothalamin results in increased expression of PMAIP1 protein]; pifithrin inhibits the reaction [Simvastatin results in increased expression of PMAIP1 mRNA] pifithrin results in decreased expression of PMAIP1 protein pifithrin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PMAIP1 protein] |
CTD |
PMID:20045437 PMID:21810437 PMID:33031904 PMID:35022897 |
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NCBI chr18:59,899,996...59,904,305
Ensembl chr18:59,899,996...59,904,305
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G |
POLH |
DNA polymerase eta |
multiple interactions |
EXP |
pifithrin inhibits the reaction [benzo(a)pyrene diolepoxide I results in increased expression of POLH mRNA]; pifithrin inhibits the reaction [fotemustine results in increased expression of POLH mRNA]; pifithrin inhibits the reaction [fotemustine results in increased expression of POLH protein]; pifithrin inhibits the reaction [Lomustine results in increased expression of POLH protein] |
CTD |
PMID:25125662 PMID:27694624 |
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NCBI chr 6:43,576,185...43,620,523
Ensembl chr 6:43,576,185...43,620,523
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G |
PRKAA1 |
protein kinase AMP-activated catalytic subunit alpha 1 |
multiple interactions |
EXP |
[pifithrin co-treated with Quercetin] results in increased phosphorylation of PRKAA1 protein |
CTD |
PMID:24535669 |
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NCBI chr 5:40,759,389...40,798,374
Ensembl chr 5:40,759,389...40,798,374
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G |
PRKDC |
protein kinase, DNA-activated, catalytic subunit |
multiple interactions |
EXP |
pifithrin inhibits the reaction [Capsaicin results in increased phosphorylation of PRKDC protein] |
CTD |
PMID:22226932 |
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NCBI chr 8:47,773,111...47,960,136
Ensembl chr 8:47,773,111...47,960,178
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G |
PSEN2 |
presenilin 2 |
multiple interactions |
EXP |
pifithrin inhibits the reaction [PSEN2 protein mutant form promotes the reaction [Staurosporine results in increased activity of CASP3 protein]] |
CTD |
PMID:12556443 |
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NCBI chr 1:226,870,616...226,903,668
Ensembl chr 1:226,870,184...226,927,726
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G |
PTEN |
phosphatase and tensin homolog |
multiple interactions |
EXP |
pifithrin inhibits the reaction [5-Methoxypsoralen results in increased expression of PTEN protein] |
CTD |
PMID:30576070 |
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NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,862,638...87,971,930
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G |
PTGS2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
pifithrin inhibits the reaction [Diquat results in increased expression of PTGS2 protein] |
CTD |
PMID:29484840 |
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NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
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G |
RAD51 |
RAD51 recombinase |
multiple interactions |
EXP |
pifithrin inhibits the reaction [tetrachlorobenzoquinone results in decreased expression of RAD51 protein] |
CTD |
PMID:27989139 |
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NCBI chr15:40,694,733...40,732,340
Ensembl chr15:40,694,774...40,732,340
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G |
RAF1 |
Raf-1 proto-oncogene, serine/threonine kinase |
multiple interactions |
EXP |
[pifithrin co-treated with Paclitaxel] results in increased phosphorylation of RAF1 protein |
CTD |
PMID:18516295 |
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NCBI chr 3:12,583,601...12,664,117
Ensembl chr 3:12,582,101...12,664,201
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G |
RB1 |
RB transcriptional corepressor 1 |
multiple interactions |
ISO |
pifithrin inhibits the reaction [Humic Substances results in decreased expression of RB1 protein] |
CTD |
PMID:18683188 |
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NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436
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G |
RELA |
RELA proto-oncogene, NF-kB subunit |
multiple interactions increases expression |
ISO |
pifithrin inhibits the reaction [Camptothecin inhibits the reaction [RELA protein binds to CREBBP protein]]; pifithrin inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]; pifithrin inhibits the reaction [triptolide results in decreased expression of RELA protein]; pifithrin promotes the reaction [RELA protein binds to CREBBP protein] pifithrin results in increased activity of [NFKB1 protein binds to RELA protein] pifithrin results in increased expression of RELA protein |
CTD |
PMID:12665479 PMID:13679428 PMID:16061640 PMID:31618665 |
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NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090
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G |
S100A9 |
S100 calcium binding protein A9 |
multiple interactions |
ISO |
pifithrin inhibits the reaction [Isoproterenol results in increased expression of S100A9 protein] |
CTD |
PMID:32924446 |
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NCBI chr 1:153,357,854...153,361,023
Ensembl chr 1:153,357,854...153,361,023
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G |
SESN1 |
sestrin 1 |
multiple interactions |
EXP |
pifithrin inhibits the reaction [sodium arsenite results in increased expression of SESN1 mRNA] |
CTD |
PMID:26148435 |
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NCBI chr 6:108,984,309...109,094,846
Ensembl chr 6:108,984,309...109,094,846
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G |
SESN2 |
sestrin 2 |
multiple interactions |
ISO EXP |
pifithrin inhibits the reaction [Rotenone results in increased expression of SESN2 protein] [pifithrin co-treated with Arsenic Trioxide] results in increased expression of SESN2 mRNA; [pifithrin co-treated with Quercetin] results in increased expression of SESN2 protein |
CTD |
PMID:24535669 PMID:26031332 PMID:35030298 |
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NCBI chr 1:28,259,518...28,282,491
Ensembl chr 1:28,259,518...28,282,491
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G |
SLC2A1 |
solute carrier family 2 member 1 |
multiple interactions |
ISO EXP |
pifithrin inhibits the reaction [triptolide results in decreased expression of SLC2A1 protein] pifithrin inhibits the reaction [icaritin results in decreased expression of SLC2A1 mRNA]; pifithrin inhibits the reaction [icaritin results in decreased expression of SLC2A1 protein] |
CTD |
PMID:31618665 PMID:38431053 |
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NCBI chr 1:42,925,353...42,958,868
Ensembl chr 1:42,925,353...42,958,893
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G |
SLC2A4 |
solute carrier family 2 member 4 |
multiple interactions |
ISO |
pifithrin inhibits the reaction [triptolide results in decreased expression of SLC2A4 protein] |
CTD |
PMID:31618665 |
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NCBI chr17:7,281,718...7,288,257
Ensembl chr17:7,281,718...7,288,257
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G |
SLC7A11 |
solute carrier family 7 member 11 |
multiple interactions |
ISO |
pifithrin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SLC7A11 protein] |
CTD |
PMID:33737050 |
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NCBI chr 4:138,164,097...138,312,671
Ensembl chr 4:138,164,097...138,242,349
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G |
SNAI1 |
snail family transcriptional repressor 1 |
multiple interactions increases expression |
EXP |
pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SNAI1 mRNA] pifithrin results in increased expression of SNAI1 protein |
CTD |
PMID:20064835 PMID:32687844 |
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NCBI chr20:49,982,980...49,988,886
Ensembl chr20:49,982,980...49,988,886
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G |
SNAI2 |
snail family transcriptional repressor 2 |
increases expression |
EXP |
pifithrin results in increased expression of SNAI2 protein |
CTD |
PMID:32687844 |
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NCBI chr 8:48,917,598...48,921,429
Ensembl chr 8:48,917,598...48,921,740
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G |
SOD2 |
superoxide dismutase 2 |
multiple interactions |
ISO |
pifithrin inhibits the reaction [Rosiglitazone results in increased expression of SOD2 protein] |
CTD |
PMID:19226370 |
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NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
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G |
SOX30 |
SRY-box transcription factor 30 |
multiple interactions |
EXP |
pifithrin inhibits the reaction [SOX30 protein results in increased expression of TP53 mRNA]; pifithrin inhibits the reaction [SOX30 protein results in increased expression of TP53 protein] |
CTD |
PMID:25435374 |
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NCBI chr 5:157,625,679...157,671,480
Ensembl chr 5:157,625,679...157,671,480
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G |
STAR |
steroidogenic acute regulatory protein |
multiple interactions |
ISO |
pifithrin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of STAR protein] |
CTD |
PMID:32199951 |
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NCBI chr 8:38,142,700...38,150,952
Ensembl chr 8:38,142,700...38,150,992
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G |
STK17A |
serine/threonine kinase 17a |
multiple interactions |
EXP |
pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of STK17A mRNA] |
CTD |
PMID:20064835 |
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NCBI chr 7:43,583,108...43,627,379
Ensembl chr 7:43,582,758...43,650,713
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G |
TGFA |
transforming growth factor alpha |
decreases expression multiple interactions |
ISO |
pifithrin results in decreased expression of TGFA protein TP53 protein affects the reaction [pifithrin results in decreased expression of TGFA protein] |
CTD |
PMID:12143041 |
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NCBI chr 2:70,447,284...70,553,826
Ensembl chr 2:70,447,284...70,554,193
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G |
TNF |
tumor necrosis factor |
multiple interactions |
ISO |
pifithrin inhibits the reaction [Diquat results in increased expression of TNF protein] |
CTD |
PMID:29484840 |
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NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
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G |
TP53 |
tumor protein p53 |
affects expression decreases activity multiple interactions decreases expression decreases phosphorylation |
ISO EXP |
pifithrin affects the expression of TRP53 protein pifithrin results in decreased activity of TRP53 protein [pifithrin co-treated with cobaltous chloride] results in increased expression of and affects the localization of TP53 protein; [pifithrin results in decreased activity of TP53 protein] results in decreased susceptibility to [Oxaliplatin results in increased activity of CASP3 protein]; [pifithrin results in decreased activity of TP53 protein] which results in decreased susceptibility to Oxaliplatin; [pifithrin results in decreased phosphorylation of TP53 protein] inhibits the reaction [Oxaliplatin results in increased expression of H2AX protein modified form]; pifithrin inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of TP53 protein]; pifithrin inhibits the reaction [[Air Pollutants results in increased abundance of Benzo(a)pyrene] which results in increased expression of TP53 mRNA]; pifithrin inhibits the reaction [[KITLG protein co-treated with EDN1 protein] results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Asbestos, Amosite affects the localization of TP53 protein]; pifithrin inhibits the reaction [Asbestos, Amosite results in increased expression of TP53 protein]; pifithrin inhibits the reaction [Benzo(a)pyrene results in increased expression of TP53 protein]; pifithrin inhibits the reaction [Capsaicin results in increased phosphorylation of and results in increased activity of TP53 protein]; pifithrin inhibits the reaction [Celecoxib results in increased expression of TP53 protein]; pifithrin inhibits the reaction [Cisplatin results in increased expression of TP53 protein]; pifithrin inhibits the reaction [CITED2 mutant form promotes the reaction [Cisplatin results in increased expression of TP53 protein]]; pifithrin inhibits the reaction [di-n-propyldithiocarbamate results in increased expression of and results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Ellagic Acid promotes the reaction [Quercetin results in increased phosphorylation of TP53 protein]]; pifithrin inhibits the reaction [Etoposide results in increased activity of TP53 protein]; pifithrin inhibits the reaction [Gentian Violet promotes the reaction [TP53 protein results in increased expression of BAX mRNA]]; pifithrin inhibits the reaction [Gentian Violet promotes the reaction [TP53 protein results in increased expression of BBC3 mRNA]]; pifithrin inhibits the reaction [goniothalamin results in increased phosphorylation of and results in increased expression of TP53 protein]; pifithrin inhibits the reaction [KITLG protein results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [olaquindox results in decreased expression of TP53 protein]; pifithrin inhibits the reaction [Particulate Matter affects the localization of TRP53 protein]; pifithrin inhibits the reaction [Particulate Matter results in increased expression of TRP53 mRNA]; pifithrin inhibits the reaction [Particulate Matter results in increased expression of TRP53 protein]; pifithrin inhibits the reaction [Pyrroles analog results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Quercetin results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Reactive Oxygen Species affects the localization of TP53 protein]; pifithrin inhibits the reaction [Resveratrol results in increased expression of and results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Resveratrol results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Silybin results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Simvastatin results in increased expression of TP53 protein]; pifithrin inhibits the reaction [Smoke analog results in increased expression of TP53 mRNA]; pifithrin inhibits the reaction [SOX30 protein results in increased expression of TP53 mRNA]; pifithrin inhibits the reaction [SOX30 protein results in increased expression of TP53 protein]; pifithrin inhibits the reaction [TP53 protein promotes the reaction [chromium hexavalent ion results in decreased expression of BUB1B protein]]; pifithrin inhibits the reaction [TP53 protein results in increased susceptibility to Resveratrol]; pifithrin inhibits the reaction [TP53 protein results in increased susceptibility to trichostatin A]; pifithrin inhibits the reaction [TP53 results in increased susceptibility to Celecoxib]; pifithrin results in decreased expression of and results in decreased phosphorylation of TP53 protein; pifithrin results in decreased susceptibility to [Oxaliplatin results in increased expression of TP53 protein modified form]; pifithrin results in decreased susceptibility to [Oxaliplatin results in increased expression of TP53 protein] pifithrin results in decreased expression of TP53 mRNA; pifithrin results in decreased expression of TP53 protein pifithrin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TP53 protein]; pifithrin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TP53 protein]; pifithrin inhibits the reaction [APP protein alternative form results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Arsenic Trioxide results in increased activity of TP53 protein]; pifithrin inhibits the reaction [Camptothecin promotes the reaction [TP53 protein binds to CREBBP protein]]; pifithrin inhibits the reaction [Camptothecin results in increased activity of TP53 protein]; pifithrin inhibits the reaction [Cisplatin results in increased activity of TP53 protein]; pifithrin inhibits the reaction [cyanoginosin LR results in increased expression of TP53 protein]; pifithrin inhibits the reaction [dibenzo(a,l)pyrene results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Diquat results in increased expression of and affects the localization of TP53 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased expression of and results in increased localization of TP53 protein modified form]; pifithrin inhibits the reaction [Doxorubicin results in increased expression of and results in increased phosphorylation of and results in increased activity of TP53 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased localization of TP53 protein]; pifithrin inhibits the reaction [Isoproterenol results in increased expression of and results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Lipopolysaccharides results in increased localization of TP53 protein]; pifithrin inhibits the reaction [Ropivacaine results in increased expression of TP53 mRNA]; pifithrin inhibits the reaction [Ropivacaine results in increased expression of TP53 protein]; pifithrin inhibits the reaction [TP53 protein results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [TP53 protein results in increased susceptibility to Cisplatin]; pifithrin inhibits the reaction [triptolide results in increased expression of and results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [triptolide results in increased expression of TP53 protein modified form]; pifithrin inhibits the reaction [triptolide results in increased expression of TP53 protein]; pifithrin results in decreased expression of and results in decreased phosphorylation of TP53 protein; TP53 protein affects the reaction [pifithrin results in decreased expression of TGFA protein] 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [pifithrin results in increased expression of and results in increased activity of TRP53 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [pifithrin results in increased expression of and results in increased activity of TRP53 protein]; [pifithrin results in decreased activity of TP53 protein] which results in decreased susceptibility to deoxynivalenol; [pifithrin results in decreased activity of TRP53 protein] inhibits the reaction [zearalenol affects the abundance of Reactive Oxygen Species]; [pifithrin results in decreased activity of TRP53 protein] which results in decreased susceptibility to zearalenol; pifithrin inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Cisplatin results in increased acetylation of TRP53 protein]]]; pifithrin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased phosphorylation of TRP53 protein]; pifithrin inhibits the reaction [Cisplatin results in increased acetylation of TRP53 protein]; pifithrin inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased expression of TRP53 protein]; pifithrin inhibits the reaction [deoxynivalenol results in increased phosphorylation of and results in increased activity of TRP53 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased expression of and results in increased phosphorylation of TRP53 protein]; pifithrin inhibits the reaction [Lipopolysaccharides results in increased expression of TRP53 mRNA]; pifithrin inhibits the reaction [Vanadates results in increased activity of TRP53 protein]; pifithrin inhibits the reaction [Vehicle Emissions results in increased phosphorylation of TRP53 protein]; pifithrin results in increased expression of and results in increased phosphorylation of and results in increased activity of TRP53 protein; TRP53 protein affects the reaction [pifithrin results in decreased expression of CDKN1A mRNA] |
CTD |
PMID:10702639 PMID:11279278 PMID:11889192 PMID:11914272 PMID:11931974 PMID:12143041 PMID:12413886 PMID:12665479 PMID:12884365 PMID:12893085 PMID:13679428 PMID:14766674 PMID:15144874 PMID:15315938 PMID:15735102 PMID:15976193 PMID:16005925 PMID:16087272 PMID:16258175 PMID:16357363 PMID:16467109 PMID:16687611 PMID:16777994 PMID:16814113 PMID:16882877 PMID:16946128 PMID:17487067 PMID:17670903 PMID:18364113 PMID:18550754 PMID:18775851 PMID:18940243 PMID:19098008 PMID:19706164 PMID:19735649 PMID:20045437 PMID:20708607 PMID:20878077 PMID:21593185 PMID:21660965 PMID:21810437 PMID:22226932 PMID:22491426 PMID:22886373 PMID:22983795 PMID:23152798 PMID:23376438 PMID:23380477 PMID:23665932 PMID:24535435 PMID:24567336 PMID:25435374 PMID:25956474 PMID:26259609 PMID:26884717 PMID:28757460 PMID:29484840 PMID:30009776 PMID:30543781 PMID:31157505 PMID:31618665 PMID:32540572 PMID:32687844 PMID:32924446 PMID:33031904 PMID:33737050 PMID:34091999 PMID:35908932 PMID:36982514 More...
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NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546
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G |
TP53BP1 |
tumor protein p53 binding protein 1 |
multiple interactions |
EXP |
pifithrin inhibits the reaction [Etoposide results in increased expression of and affects the localization of TP53BP1 protein] |
CTD |
PMID:26259609 |
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NCBI chr15:43,403,061...43,510,640
Ensembl chr15:43,403,061...43,510,728
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G |
TYR |
tyrosinase |
decreases expression |
EXP |
pifithrin results in decreased expression of TYR mRNA; pifithrin results in decreased expression of TYR protein |
CTD |
PMID:19098008 |
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NCBI chr11:89,177,875...89,295,759
Ensembl chr11:89,177,875...89,295,759
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G |
USP8 |
ubiquitin specific peptidase 8 |
multiple interactions |
EXP |
pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased expression of BAX protein]; pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased expression of PMAIP1 protein] |
CTD |
PMID:35022897 |
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NCBI chr15:50,424,405...50,514,421
Ensembl chr15:50,424,380...50,514,421
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G |
VIM |
vimentin |
multiple interactions |
EXP |
pifithrin inhibits the reaction [di-n-propyldithiocarbamate results in decreased expression of VIM protein] |
CTD |
PMID:32687844 |
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NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593
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G |
XIAP |
X-linked inhibitor of apoptosis |
multiple interactions |
EXP |
[Topotecan co-treated with pifithrin] results in increased degradation of XIAP protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[pifithrin co-treated with Topotecan] results in increased degradation of XIAP protein] |
CTD |
PMID:19812371 |
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NCBI chr X:123,859,708...123,913,972
Ensembl chr X:123,859,712...123,913,972
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G |
XPC |
XPC complex subunit, DNA damage recognition and repair factor |
multiple interactions |
EXP |
pifithrin inhibits the reaction [benzo(a)pyrene diolepoxide I results in increased expression of XPC mRNA] |
CTD |
PMID:27694624 |
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NCBI chr 3:14,145,147...14,178,601
Ensembl chr 3:14,145,145...14,178,621
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G |
SLC5A5 |
solute carrier family 5 member 5 |
multiple interactions |
EXP |
sodium bromide inhibits the reaction [SLC5A5 protein results in increased uptake of perrhenate analog]; sodium bromide inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide analog]; sodium bromide inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Pertechnetate Tc 99m] |
CTD |
PMID:12488351 |
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NCBI chr19:17,871,945...17,895,174
Ensembl chr19:17,871,945...17,895,174
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G |
CHRM1 |
cholinergic receptor muscarinic 1 |
affects binding |
EXP |
Tiotropium Bromide binds to CHRM1 protein |
CTD |
PMID:21870878 |
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NCBI chr11:62,908,679...62,921,878
Ensembl chr11:62,908,679...62,921,807
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G |
CHRM2 |
cholinergic receptor muscarinic 2 |
affects binding |
EXP |
Tiotropium Bromide binds to CHRM2 protein |
CTD |
PMID:21870878 |
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NCBI chr 7:136,868,652...137,020,213
Ensembl chr 7:136,868,652...137,020,255
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G |
CHRM3 |
cholinergic receptor muscarinic 3 |
affects binding |
EXP |
Tiotropium Bromide binds to CHRM3 protein |
CTD |
PMID:21870878 |
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NCBI chr 1:239,386,568...239,915,450
Ensembl chr 1:239,386,565...239,915,452
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G |
CHRM4 |
cholinergic receptor muscarinic 4 |
affects binding |
EXP |
Tiotropium Bromide binds to CHRM4 protein |
CTD |
PMID:21870878 |
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NCBI chr11:46,383,789...46,391,776
Ensembl chr11:46,383,789...46,391,776
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G |
CHRM5 |
cholinergic receptor muscarinic 5 |
affects binding |
EXP |
Tiotropium Bromide binds to CHRM5 protein |
CTD |
PMID:21870878 |
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NCBI chr15:33,968,497...34,067,458
Ensembl chr15:33,968,497...34,067,458
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G |
EDN1 |
endothelin 1 |
multiple interactions |
EXP |
Tiotropium Bromide inhibits the reaction [Oxotremorine results in increased expression of EDN1 mRNA] |
CTD |
PMID:22796455 |
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NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194
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G |
PON1 |
paraoxonase 1 |
decreases activity |
EXP |
Tiotropium Bromide results in decreased activity of PON1 protein |
CTD |
PMID:31581362 |
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NCBI chr 7:95,297,676...95,324,532
Ensembl chr 7:95,297,676...95,324,532
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G |
TNF |
tumor necrosis factor |
decreases secretion |
EXP |
Tiotropium Bromide results in decreased secretion of TNF protein |
CTD |
PMID:21352583 |
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NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
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G |
KCNH2 |
potassium voltage-gated channel subfamily H member 2 |
decreases activity |
EXP |
thiaton results in decreased activity of KCNH2 protein |
CTD |
PMID:28551711 |
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NCBI chr 7:150,944,961...150,978,321
Ensembl chr 7:150,944,961...150,978,321
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G |
MPO |
myeloperoxidase |
multiple interactions |
ISO |
thiaton inhibits the reaction [Indomethacin results in increased activity of MPO protein] |
CTD |
PMID:11855677 |
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NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935
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G |
NOS2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
thiaton inhibits the reaction [Indomethacin results in increased activity of NOS2 protein] |
CTD |
PMID:11855677 |
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NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
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G |
ABCA1 |
ATP binding cassette subfamily A member 1 |
multiple interactions |
EXP |
Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCA1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCA1 protein] |
CTD |
PMID:30036686 |
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NCBI chr 9:104,781,006...104,928,155
Ensembl chr 9:104,781,006...104,928,155
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G |
ABCG1 |
ATP binding cassette subfamily G member 1 |
multiple interactions |
EXP |
Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCG1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCG1 protein] |
CTD |
PMID:30036686 |
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NCBI chr21:42,199,689...42,297,244
Ensembl chr21:42,199,689...42,304,389
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G |
CHRM1 |
cholinergic receptor muscarinic 1 |
multiple interactions |
EXP |
Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein] |
CTD |
PMID:9846649 |
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NCBI chr11:62,908,679...62,921,878
Ensembl chr11:62,908,679...62,921,807
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G |
CHRM2 |
cholinergic receptor muscarinic 2 |
multiple interactions |
EXP |
Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM2 protein] |
CTD |
PMID:9846649 |
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NCBI chr 7:136,868,652...137,020,213
Ensembl chr 7:136,868,652...137,020,255
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G |
CHRM3 |
cholinergic receptor muscarinic 3 |
multiple interactions |
EXP |
Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein] |
CTD |
PMID:9846649 |
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NCBI chr 1:239,386,568...239,915,450
Ensembl chr 1:239,386,565...239,915,452
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G |
CHRM4 |
cholinergic receptor muscarinic 4 |
multiple interactions |
EXP |
Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM4 protein] |
CTD |
PMID:9846649 |
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NCBI chr11:46,383,789...46,391,776
Ensembl chr11:46,383,789...46,391,776
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G |
CHRM5 |
cholinergic receptor muscarinic 5 |
multiple interactions |
EXP |
Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein] |
CTD |
PMID:9846649 |
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NCBI chr15:33,968,497...34,067,458
Ensembl chr15:33,968,497...34,067,458
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G |
CHRNA3 |
cholinergic receptor nicotinic alpha 3 subunit |
multiple interactions |
EXP |
Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]] |
CTD |
PMID:16931985 |
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NCBI chr15:78,593,052...78,620,996
Ensembl chr15:78,593,052...78,621,295
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G |
CHRNA4 |
cholinergic receptor nicotinic alpha 4 subunit |
multiple interactions |
EXP |
Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Vecuronium Bromide results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] |
CTD |
PMID:14645658 PMID:16931985 |
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NCBI chr20:63,343,223...63,361,349
Ensembl chr20:63,343,223...63,378,401
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G |
CHRNA7 |
cholinergic receptor nicotinic alpha 7 subunit |
multiple interactions |
EXP |
Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein] |
CTD |
PMID:16931985 |
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NCBI chr15:32,030,483...32,173,018
Ensembl chr15:31,923,438...32,173,018
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G |
CHRNB2 |
cholinergic receptor nicotinic beta 2 subunit |
multiple interactions |
EXP |
Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Vecuronium Bromide results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] |
CTD |
PMID:14645658 PMID:16931985 |
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NCBI chr 1:154,567,778...154,580,013
Ensembl chr 1:154,567,778...154,580,013
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G |
CHRNB4 |
cholinergic receptor nicotinic beta 4 subunit |
multiple interactions |
EXP |
Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]] |
CTD |
PMID:16931985 |
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NCBI chr15:78,624,111...78,661,641
Ensembl chr15:78,624,111...78,727,754
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G |
CYP11A1 |
cytochrome P450 family 11 subfamily A member 1 |
multiple interactions |
ISO |
Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP11A1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP11A1 protein] |
CTD |
PMID:31846720 |
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NCBI chr15:74,337,762...74,367,646
Ensembl chr15:74,337,759...74,367,646
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G |
CYP19A1 |
cytochrome P450 family 19 subfamily A member 1 |
multiple interactions |
EXP |
Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP19A1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP19A1 protein] |
CTD |
PMID:30959089 |
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NCBI chr15:51,208,057...51,338,596
Ensembl chr15:51,208,057...51,338,601
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G |
EGR1 |
early growth response 1 |
multiple interactions |
EXP |
Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of EGR1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of EGR1 protein] |
CTD |
PMID:29486207 |
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NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303
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G |
ELK1 |
ETS transcription factor ELK1 |
multiple interactions |
EXP |
Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of ELK1 protein] |
CTD |
PMID:29486207 |
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NCBI chr X:47,635,520...47,650,604
Ensembl chr X:47,635,520...47,650,604
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G |
HDAC4 |
histone deacetylase 4 |
multiple interactions |
ISO |
Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 protein] |
CTD |
PMID:31846720 |
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NCBI chr 2:239,048,168...239,401,649 NCBI chr 2:239,193,331...239,195,457
Ensembl chr 2:239,048,168...239,401,654
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G |
HEXB |
hexosaminidase subunit beta |
increases secretion |
EXP |
Vecuronium Bromide results in increased secretion of HEXB protein |
CTD |
PMID:19758318 |
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NCBI chr 5:74,640,023...74,721,288
Ensembl chr 5:74,640,023...74,722,647
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G |
HSD11B2 |
hydroxysteroid 11-beta dehydrogenase 2 |
increases expression multiple interactions |
EXP |
Vecuronium Bromide results in increased expression of HSD11B2 mRNA; Vecuronium Bromide results in increased expression of HSD11B2 protein Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 protein] |
CTD |
PMID:29486207 |
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NCBI chr16:67,429,801...67,437,553
Ensembl chr16:67,430,652...67,437,553
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G |
MAPK1 |
mitogen-activated protein kinase 1 |
multiple interactions |
EXP |
Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:29486207 |
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NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
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G |
MAPK3 |
mitogen-activated protein kinase 3 |
multiple interactions |
EXP |
Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:29486207 |
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NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
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G |
NR1H2 |
nuclear receptor subfamily 1 group H member 2 |
multiple interactions |
EXP |
Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H2 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H2 protein] |
CTD |
PMID:30036686 |
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NCBI chr19:50,376,457...50,383,388
Ensembl chr19:50,329,653...50,383,388
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G |
NR1H3 |
nuclear receptor subfamily 1 group H member 3 |
multiple interactions |
EXP |
Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H3 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H3 protein] |
CTD |
PMID:30036686 |
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NCBI chr11:47,248,300...47,269,033
Ensembl chr11:47,248,300...47,269,033
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G |
SCARB1 |
scavenger receptor class B member 1 |
multiple interactions |
EXP |
Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of SCARB1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of SCARB1 protein] |
CTD |
PMID:30036686 |
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NCBI chr12:124,776,856...124,863,864
Ensembl chr12:124,776,856...124,882,668
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G |
STAR |
steroidogenic acute regulatory protein |
multiple interactions |
ISO |
Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of STAR mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of STAR protein] |
CTD |
PMID:31846720 |
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NCBI chr 8:38,142,700...38,150,952
Ensembl chr 8:38,142,700...38,150,992
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