|
G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
decreases activity |
ISO |
thiazolyl blue results in decreased activity of ABCB1 protein |
CTD |
PMID:15451006 |
|
NCBI chr 4:26,312,403...26,488,456
|
|
G |
Aco2 |
aconitase 2 |
multiple interactions |
ISO |
[Calcium results in increased activity of ACO2 protein] which results in increased reduction of thiazolyl blue; [Potassium deficiency results in decreased activity of ACO2 protein] which results in decreased reduction of thiazolyl blue |
CTD |
PMID:12548706 |
|
NCBI chr 7:113,385,677...113,428,794
|
|
G |
Casp3 |
caspase 3 |
increases activity |
ISO |
thiazolyl blue results in increased activity of CASP3 protein |
CTD |
PMID:22401948 |
|
NCBI chr16:52,395,539...52,413,794
|
|
G |
Casp8 |
caspase 8 |
increases activity |
ISO |
thiazolyl blue results in increased activity of CASP8 protein |
CTD |
PMID:22401948 |
|
NCBI chr 9:67,747,109...67,806,699
|
|
G |
Nqo2 |
N-ribosyldihydronicotinamide:quinone dehydrogenase 2 |
increases reduction multiple interactions |
ISO |
NQO2 protein results in increased reduction of thiazolyl blue resveratrol inhibits the reaction [NQO2 protein results in increased reduction of thiazolyl blue]; Tacrine inhibits the reaction [NQO2 protein results in increased reduction of thiazolyl blue] |
CTD |
PMID:29281794 |
|
NCBI chr17:30,909,482...30,938,725
|
|
|
G |
Slc22a2 |
solute carrier family 22 member 2 |
multiple interactions |
ISO |
Butylscopolammonium Bromide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] |
CTD |
PMID:21599003 |
|
NCBI chr 1:50,668,817...50,711,019
|
|
|
G |
Htr1a |
5-hydroxytryptamine receptor 1A |
multiple interactions |
EXP ISO |
[1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine binds to and results in decreased activity of HTR1A protein] which results in decreased susceptibility to Serotonin [1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine binds to and results in decreased activity of HTR1A protein] which results in decreased susceptibility to Methamphetamine |
CTD |
PMID:15213358 PMID:15482641 PMID:16528294 |
|
NCBI chr 2:38,427,169...38,431,733
|
|
|
G |
Adm |
adrenomedullin |
multiple interactions |
ISO |
pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ADM mRNA] |
CTD |
PMID:20064835 |
|
NCBI chr 1:174,164,178...174,182,372
|
|
G |
Agt |
angiotensinogen |
multiple interactions |
EXP |
pifithrin inhibits the reaction [AGT protein modified form results in increased cleavage of CASP3 protein] |
CTD |
PMID:19808082 |
|
NCBI chr19:69,426,540...69,447,017
|
|
G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions affects localization |
ISO |
pifithrin binds to and results in increased activity of AHR protein pifithrin affects the localization of AHR protein |
CTD |
PMID:15843497 |
|
NCBI chr 6:57,961,423...57,998,901
|
|
G |
Aifm1 |
apoptosis inducing factor, mitochondria associated 1 |
multiple interactions |
ISO |
pifithrin inhibits the reaction [Cisplatin affects the localization of AIFM1 protein] |
CTD |
PMID:15983031 |
|
NCBI chr X:132,528,107...132,567,237
|
|
G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
[Copper Sulfate co-treated with pifithrin] results in increased phosphorylation of AKT1 protein; [pifithrin co-treated with Paclitaxel] results in decreased phosphorylation of AKT1 protein; pifithrin inhibits the reaction [5-Methoxypsoralen results in decreased phosphorylation of AKT1 protein]; pifithrin inhibits the reaction [di-n-propyldithiocarbamate results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; pifithrin inhibits the reaction [Fingolimod Hydrochloride results in decreased phosphorylation of AKT1 protein]; pifithrin results in increased expression of and results in increased phosphorylation of AKT1 protein |
CTD |
PMID:15001399 PMID:18516295 PMID:25939952 PMID:30576070 PMID:32687844 |
|
NCBI chr 6:137,534,810...137,555,131
|
|
G |
Apaf1 |
apoptotic peptidase activating factor 1 |
increases expression |
ISO |
pifithrin results in increased expression of APAF1 protein |
CTD |
PMID:28483490 |
|
NCBI chr 7:27,381,392...27,466,772
|
|
G |
App |
amyloid beta precursor protein |
multiple interactions |
EXP |
pifithrin inhibits the reaction [APP protein alternative form results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [APP protein alternative form results in increased phosphorylation of TP53 protein] |
CTD |
PMID:24567336 |
|
NCBI chr11:37,506,207...37,724,351
|
|
G |
Atf3 |
activating transcription factor 3 |
multiple interactions |
ISO |
pifithrin inhibits the reaction [sodium arsenite results in increased expression of ATF3 mRNA] |
CTD |
PMID:26148435 |
|
NCBI chr13:105,274,103...105,331,653
|
|
G |
Atm |
ATM serine/threonine kinase |
multiple interactions |
ISO |
pifithrin inhibits the reaction [Etoposide results in increased phosphorylation of and affects the localization of ATM protein] |
CTD |
PMID:26259609 |
|
NCBI chr 8:62,724,939...62,829,040
|
|
G |
Bak1 |
BCL2-antagonist/killer 1 |
multiple interactions |
EXP |
pifithrin inhibits the reaction [triptolide results in increased expression of BAK1 protein] |
CTD |
PMID:30009776 |
|
NCBI chr20:5,102,334...5,111,615
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions decreases expression |
ISO EXP |
pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased expression of BAX protein]; pifithrin inhibits the reaction [Asbestos, Amosite affects the localization of BAX protein]; pifithrin inhibits the reaction [Cisplatin results in increased expression of BAX protein]; pifithrin inhibits the reaction [CITED2 mutant form promotes the reaction [Cisplatin results in increased expression of BAX protein]]; pifithrin inhibits the reaction [Gentian Violet promotes the reaction [TP53 protein results in increased expression of BAX mRNA]]; pifithrin inhibits the reaction [Particulate Matter affects the localization of BAX protein]; pifithrin inhibits the reaction [Pyrroles analog results in increased expression of BAX protein]; pifithrin inhibits the reaction [Reactive Oxygen Species results in increased expression of BAX protein]; pifithrin inhibits the reaction [Smoke analog results in increased expression of BAX mRNA]; pifithrin inhibits the reaction [Smoke analog results in increased expression of BAX protein] pifithrin inhibits the reaction [Doxorubicin results in increased expression of BAX mRNA]; pifithrin inhibits the reaction [Rotenone results in increased expression of BAX protein]; pifithrin inhibits the reaction [Vehicle Emissions results in increased expression of BAX protein] pifithrin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BAX protein]; pifithrin inhibits the reaction [Camptothecin results in increased expression of BAX protein]; pifithrin inhibits the reaction [Doxorubicin results in increased expression of BAX protein]; pifithrin inhibits the reaction [Humic Substances results in increased expression of BAX protein]; pifithrin inhibits the reaction [Ropivacaine results in increased expression of BAX mRNA]; pifithrin inhibits the reaction [Ropivacaine results in increased expression of BAX protein]; pifithrin inhibits the reaction [triptolide results in increased expression of BAX protein] pifithrin results in decreased expression of BAX protein |
CTD |
PMID:11279278 PMID:12893085 PMID:14766674 PMID:16357363 PMID:16946128 PMID:18683188 PMID:18775851 PMID:18940243 PMID:21660965 PMID:23665932 PMID:24535435 PMID:26031332 PMID:26884717 PMID:30009776 PMID:30543781 PMID:33031904 PMID:34091999 PMID:35022897 More...
|
|
NCBI chr 1:105,076,472...105,081,906
|
|
G |
Bbc3 |
Bcl-2 binding component 3 |
multiple interactions decreases expression |
ISO EXP |
pifithrin inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Cisplatin results in increased expression of BBC3 protein]]] pifithrin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [APP protein alternative form results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [cyanoginosin LR results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased expression of BBC3 protein] pifithrin inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [5-Methoxypsoralen results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [Gentian Violet promotes the reaction [TP53 protein results in increased expression of BBC3 mRNA]]; pifithrin inhibits the reaction [Simvastatin results in increased expression of BBC3 mRNA]; pifithrin inhibits the reaction [Simvastatin results in increased expression of BBC3 protein] pifithrin results in decreased expression of BBC3 mRNA; pifithrin results in decreased expression of BBC3 protein |
CTD |
PMID:18364113 PMID:18775851 PMID:19095966 PMID:19475672 PMID:20045437 PMID:21593185 PMID:24535435 PMID:24567336 PMID:30576070 PMID:31157505 PMID:32540572 PMID:33031904 PMID:35022897 More...
|
|
NCBI chr 1:86,141,450...86,150,666
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
EXP ISO |
pifithrin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BCL2 protein]; pifithrin inhibits the reaction [Arsenic Trioxide results in increased expression of BCL2 mRNA]; pifithrin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; pifithrin inhibits the reaction [Ropivacaine results in decreased expression of BCL2 mRNA]; pifithrin inhibits the reaction [Ropivacaine results in decreased expression of BCL2 protein]; pifithrin inhibits the reaction [triptolide results in decreased expression of BCL2 protein] [pifithrin co-treated with Arsenic Trioxide] results in decreased expression of BCL2 protein; [pifithrin co-treated with Paclitaxel] results in increased phosphorylation of BCL2 protein; pifithrin inhibits the reaction [Pyrroles analog results in decreased expression of BCL2 protein]; pifithrin inhibits the reaction [Reactive Oxygen Species results in decreased expression of BCL2 protein] |
CTD |
PMID:17487067 PMID:18516295 PMID:18775851 PMID:26884717 PMID:30009776 PMID:30543781 PMID:33031904 PMID:34091999 PMID:35030298 More...
|
|
NCBI chr13:23,204,464...23,366,900
|
|
G |
Bcl2l1 |
Bcl2-like 1 |
multiple interactions |
ISO EXP |
[Puromycin Aminonucleoside co-treated with pifithrin] results in increased expression of BCL2L1 protein; pifithrin inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Cisplatin results in decreased expression of BCL2L1]]] pifithrin inhibits the reaction [triptolide results in decreased expression of BCL2L1 protein] |
CTD |
PMID:15987750 PMID:21593185 PMID:30009776 |
|
NCBI chr 3:161,713,777...161,764,844
|
|
G |
Bid |
BH3 interacting domain death agonist |
multiple interactions |
ISO |
pifithrin inhibits the reaction [Silybin results in increased cleavage of BID protein] |
CTD |
PMID:16777994 |
|
NCBI chr 4:155,785,366...155,808,775
|
|
G |
Birc5 |
baculoviral IAP repeat-containing 5 |
multiple interactions |
ISO |
[Topotecan co-treated with pifithrin] results in increased degradation of BIRC5 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[pifithrin co-treated with Topotecan] results in increased degradation of BIRC5 protein] |
CTD |
PMID:19812371 |
|
NCBI chr10:103,567,369...103,580,069
|
|
G |
Brca1 |
BRCA1, DNA repair associated |
multiple interactions |
ISO |
pifithrin inhibits the reaction [Etoposide results in increased expression of and affects the localization of BRCA1 protein] |
CTD |
PMID:26259609 |
|
NCBI chr10:86,917,693...86,978,012
|
|
G |
Bub1b |
BUB1 mitotic checkpoint serine/threonine kinase B |
multiple interactions |
ISO |
pifithrin inhibits the reaction [TP53 protein promotes the reaction [chromium hexavalent ion results in decreased expression of BUB1B protein]] |
CTD |
PMID:22886373 |
|
NCBI chr 3:126,017,019...126,069,470
|
|
G |
C3 |
complement C3 |
multiple interactions |
EXP |
pifithrin inhibits the reaction [Isoproterenol results in increased expression of C3 protein] |
CTD |
PMID:32924446 |
|
NCBI chr 9:2,174,412...2,201,339
|
|
G |
C5 |
complement C5 |
multiple interactions |
EXP |
pifithrin inhibits the reaction [Isoproterenol results in increased expression of C5 protein] |
CTD |
PMID:32924446 |
|
NCBI chr 3:38,668,174...38,759,468
|
|
G |
Casp12 |
caspase 12 |
multiple interactions |
EXP |
pifithrin inhibits the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP12 protein] |
CTD |
PMID:16687611 |
|
NCBI chr 8:10,927,188...10,954,442
|
|
G |
Casp2 |
caspase 2 |
multiple interactions |
ISO EXP |
pifithrin inhibits the reaction [Cisplatin results in increased activity of CASP2 protein] pifithrin inhibits the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP2 protein] pifithrin inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP2 protein]; pifithrin promotes the reaction [Topotecan results in increased cleavage of CASP2 protein] |
CTD |
PMID:15983031 PMID:16687611 PMID:16777994 PMID:19812371 |
|
NCBI chr 4:72,116,265...72,134,023
|
|
G |
Casp3 |
caspase 3 |
multiple interactions increases cleavage decreases activity decreases expression |
EXP ISO |
pifithrin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [AGT protein modified form results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [cyanoginosin LR results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [Diquat results in increased expression of CASP3 protein modified form]; pifithrin inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP3 protein]; pifithrin inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]; pifithrin inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [Ropivacaine results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [Ropivacaine results in increased expression of CASP3 mRNA]; pifithrin inhibits the reaction [triptolide results in increased cleavage of CASP3 protein] pifithrin results in increased cleavage of CASP3 protein pifithrin results in decreased activity of CASP3 protein [pifithrin co-treated with Paclitaxel] results in increased cleavage of and results in increased activity of CASP3 protein; [pifithrin co-treated with thiocholchicine] results in increased cleavage of and results in increased activity of CASP3 protein; [pifithrin co-treated with Vinorelbine] results in increased cleavage of and results in increased activity of CASP3 protein; [pifithrin results in decreased activity of TP53 protein] results in decreased susceptibility to [Oxaliplatin results in increased activity of CASP3 protein]; [pifithrin results in increased susceptibility to Plant Preparations] which results in increased cleavage of CASP3 protein; pifithrin inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in decreased cleavage of CASP3 protein]; pifithrin inhibits the reaction [2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone analog results in decreased expression of CASP3 protein]; pifithrin inhibits the reaction [5-Methoxypsoralen results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [[Oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased activity of CASP3 protein]; pifithrin inhibits the reaction [Mustard Gas results in decreased cleavage of CASP3 protein]; pifithrin inhibits the reaction [PSEN2 protein mutant form promotes the reaction [Staurosporine results in increased activity of CASP3 protein]]; pifithrin inhibits the reaction [Pyrroles analog results in increased expression of CASP3 protein modified form]; pifithrin inhibits the reaction [Reactive Oxygen Species results in increased activity of CASP3 protein]; pifithrin inhibits the reaction [Silicon Dioxide results in increased expression of CASP3 protein modified form]; pifithrin inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP3 protein]; pifithrin promotes the reaction [Etoposide results in increased activity of CASP3 protein]; pifithrin promotes the reaction [Etoposide results in increased cleavage of CASP3 protein] pifithrin results in decreased expression of CASP3 protein pifithrin inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein]]]; pifithrin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [deoxynivalenol results in increased activity of CASP3 protein]; pifithrin inhibits the reaction [Vehicle Emissions results in increased activity of CASP3 protein]; pifithrin promotes the reaction [2,4-dibromophenol metabolite results in increased expression of CASP3 protein modified form]; pifithrin promotes the reaction [quinone analog results in increased expression of CASP3 protein modified form]; pifithrin promotes the reaction [Topotecan results in increased activity of CASP3 protein] |
CTD |
PMID:12556443 PMID:12665479 PMID:15144874 PMID:15976193 PMID:16687611 PMID:16777994 PMID:18364113 PMID:18516295 PMID:18775851 PMID:18940243 PMID:19728331 PMID:19808082 PMID:19812371 PMID:20708607 PMID:21593185 PMID:25448276 PMID:26259609 PMID:26451628 PMID:26630137 PMID:26884717 PMID:28483490 PMID:29484840 PMID:29698619 PMID:30009776 PMID:30543781 PMID:30576070 PMID:31082419 PMID:31157505 PMID:32924446 PMID:33031904 PMID:33961949 PMID:34091999 PMID:35908932 More...
|
|
NCBI chr16:52,395,539...52,413,794
|
|
G |
Casp7 |
caspase 7 |
multiple interactions |
EXP ISO |
pifithrin inhibits the reaction [cordycepin results in increased cleavage of CASP7 protein] pifithrin promotes the reaction [Etoposide results in increased activity of CASP7 protein] |
CTD |
PMID:24704558 PMID:26259609 |
|
NCBI chr 1:265,442,647...265,481,938
|
|
G |
Casp8 |
caspase 8 |
multiple interactions |
ISO EXP |
pifithrin inhibits the reaction [[Decitabine co-treated with Busulfan] results in increased activity of CASP8 protein]; pifithrin inhibits the reaction [[Oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased activity of CASP8 protein]; pifithrin inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP8 protein] pifithrin inhibits the reaction [Doxorubicin results in increased activity of CASP8 protein] |
CTD |
PMID:16687611 PMID:16777994 PMID:19728331 PMID:19732952 |
|
NCBI chr 9:67,747,109...67,806,699
|
|
G |
Casp9 |
caspase 9 |
multiple interactions |
ISO EXP |
pifithrin inhibits the reaction [5-Methoxypsoralen results in increased cleavage of CASP9 protein]; pifithrin inhibits the reaction [[Decitabine co-treated with Busulfan] results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [cobaltous chloride results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [nickel chloride results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [Particulate Matter results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [Reactive Oxygen Species results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP9 protein]; pifithrin promotes the reaction [Mustard Gas results in increased cleavage of CASP9 protein] pifithrin inhibits the reaction [Doxorubicin results in increased activity of CASP9 protein] pifithrin inhibits the reaction [Asbestos, Amosite results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased cleavage of CASP9 protein]; pifithrin inhibits the reaction [Humic Substances results in increased cleavage of CASP9 protein]; pifithrin inhibits the reaction [Particulate Matter results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [triptolide results in increased expression of CASP9 protein modified form] |
CTD |
PMID:16357363 PMID:16687611 PMID:16777994 PMID:16946128 PMID:18683188 PMID:18775851 PMID:19732952 PMID:23380477 PMID:23566959 PMID:25448276 PMID:26884717 PMID:29653124 PMID:30009776 PMID:30576070 More...
|
|
|
|
G |
Ccnb1 |
cyclin B1 |
multiple interactions increases expression |
ISO |
[pifithrin co-treated with Paclitaxel] results in increased expression of CCNB1 protein pifithrin results in increased expression of CCNB1 mRNA; pifithrin results in increased expression of CCNB1 protein |
CTD |
PMID:16620711 PMID:18516295 |
|
NCBI chr 2:33,646,252...33,655,225
|
|
G |
Ccng1 |
cyclin G1 |
multiple interactions |
EXP |
pifithrin inhibits the reaction [Arsenic Trioxide results in increased expression of CCNG1 mRNA] |
CTD |
PMID:17487067 |
|
NCBI chr10:25,678,503...25,684,876
|
|
G |
Ccng2 |
cyclin G2 |
multiple interactions |
ISO |
[pifithrin co-treated with Arsenic Trioxide] results in increased expression of CCNG2 mRNA |
CTD |
PMID:35030298 |
|
NCBI chr14:15,088,694...15,097,190
|
|
G |
Cdc25a |
cell division cycle 25A |
multiple interactions |
ISO |
pifithrin inhibits the reaction [sodium arsenite results in decreased expression of CDC25A mRNA] |
CTD |
PMID:26148435 |
|
NCBI chr 8:118,742,824...118,761,190
|
|
G |
Cdc25c |
cell division cycle 25C |
multiple interactions |
ISO |
[pifithrin co-treated with Paclitaxel] results in increased phosphorylation of CDC25C protein |
CTD |
PMID:18516295 |
|
NCBI chr18:26,608,483...26,630,292
|
|
G |
Cdh1 |
cadherin 1 |
multiple interactions decreases expression |
ISO |
pifithrin inhibits the reaction [di-n-propyldithiocarbamate results in increased expression of CDH1 protein] pifithrin results in decreased expression of CDH1 protein |
CTD |
PMID:32687844 |
|
NCBI chr19:51,402,178...51,471,572
|
|
G |
Cdk1 |
cyclin-dependent kinase 1 |
increases expression multiple interactions increases phosphorylation |
ISO |
pifithrin results in increased expression of CDK1 protein [pifithrin co-treated with Paclitaxel] results in decreased phosphorylation of CDK1 protein pifithrin results in increased phosphorylation of CDK1 protein |
CTD |
PMID:16620711 PMID:18516295 |
|
NCBI chr20:19,265,252...19,280,456
|
|
G |
Cdk2 |
cyclin dependent kinase 2 |
multiple interactions |
ISO |
pifithrin inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in decreased expression of CDK2 protein] |
CTD |
PMID:26451628 |
|
NCBI chr 7:1,714,392...1,721,964
|
|
G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression multiple interactions decreases expression |
ISO EXP |
pifithrin results in increased expression of CDKN1A protein pifithrin inhibits the reaction [arecoline hydrobromide results in increased expression of CDKN1A mRNA]; pifithrin inhibits the reaction [arecoline hydrobromide results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [Arsenic Trioxide results in increased expression of CDKN1A mRNA]; pifithrin inhibits the reaction [Benzo(a)pyrene results in increased expression of CDKN1A mRNA]; pifithrin inhibits the reaction [Benzo(a)pyrene results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [cyanoginosin LR results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [TP53 protein results in increased expression of CDKN1A protein] pifithrin inhibits the reaction [2,4-dibromophenol metabolite results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [quinone analog results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [Vanadates results in increased activity of CDKN1A protein]; TRP53 protein affects the reaction [pifithrin results in decreased expression of CDKN1A mRNA] pifithrin inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [5-Methoxypsoralen results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [[Air Pollutants results in increased abundance of Benzo(a)pyrene] which results in increased expression of CDKN1A mRNA]; pifithrin inhibits the reaction [[Air Pollutants results in increased abundance of Benzo(a)pyrene] which results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [Benzo(a)pyrene results in increased expression of CDKN1A mRNA]; pifithrin inhibits the reaction [Decitabine results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [Ellagic Acid promotes the reaction [Quercetin results in increased expression of CDKN1A protein]]; pifithrin inhibits the reaction [Paclitaxel results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [Quercetin results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [Resveratrol results in increased expression of CDKN1A mRNA]; pifithrin results in decreased susceptibility to [1-nitropyrene results in increased expression of CDKN1A protein] pifithrin results in decreased expression of CDKN1A protein |
CTD |
PMID:11889192 PMID:11931974 PMID:12413886 PMID:12893085 PMID:15144874 PMID:15735102 PMID:17487067 PMID:17997002 PMID:18223691 PMID:18516295 PMID:21887816 PMID:22044530 PMID:24361490 PMID:26086121 PMID:26451628 PMID:30576070 PMID:31157505 PMID:33961949 PMID:35022897 PMID:36982514 More...
|
|
NCBI chr20:7,150,820...7,161,373
|
|
G |
Chek2 |
checkpoint kinase 2 |
multiple interactions |
ISO |
pifithrin inhibits the reaction [Etoposide results in increased phosphorylation of CHEK2 protein] |
CTD |
PMID:26259609 |
|
NCBI chr12:51,448,838...51,481,159
|
|
G |
Cited2 |
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 |
multiple interactions |
ISO |
pifithrin inhibits the reaction [CITED2 mutant form promotes the reaction [Cisplatin results in increased expression of BAX protein]]; pifithrin inhibits the reaction [CITED2 mutant form promotes the reaction [Cisplatin results in increased expression of TP53 protein]] |
CTD |
PMID:21660965 |
|
NCBI chr 1:12,312,426...12,314,869
|
|
G |
Crebbp |
CREB binding protein |
multiple interactions |
EXP |
pifithrin inhibits the reaction [Camptothecin inhibits the reaction [RELA protein binds to CREBBP protein]]; pifithrin inhibits the reaction [Camptothecin promotes the reaction [TP53 protein binds to CREBBP protein]]; pifithrin promotes the reaction [RELA protein binds to CREBBP protein] |
CTD |
PMID:13679428 |
|
NCBI chr10:11,842,307...11,968,266
|
|
G |
Cxcr4 |
C-X-C motif chemokine receptor 4 |
multiple interactions |
ISO |
pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CXCR4 mRNA] |
CTD |
PMID:20064835 |
|
NCBI chr13:42,630,383...42,634,288
|
|
G |
Cycs |
cytochrome c, somatic |
multiple interactions |
EXP |
pifithrin inhibits the reaction [Doxorubicin affects the localization of CYCS protein] |
CTD |
PMID:16687611 |
|
NCBI chr 4:80,982,667...80,984,767
|
|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
decreases activity increases expression |
ISO |
pifithrin results in decreased activity of CYP1A1 protein pifithrin results in increased expression of CYP1A1 mRNA; pifithrin results in increased expression of CYP1A1 protein |
CTD |
PMID:15698582 PMID:15843497 PMID:16258175 PMID:22044530 |
|
NCBI chr 8:66,991,940...66,998,014
|
|
G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
decreases activity increases expression |
ISO |
pifithrin results in decreased activity of CYP1A2 protein pifithrin results in increased expression of CYP1A2 mRNA; pifithrin results in increased expression of CYP1A2 protein |
CTD |
PMID:16258175 |
|
NCBI chr 8:66,971,261...66,978,149
|
|
G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
multiple interactions increases expression decreases activity |
ISO |
pifithrin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased activity of CYP1B1 protein] pifithrin results in increased expression of CYP1B1 mRNA pifithrin results in decreased activity of CYP1B1 protein |
CTD |
PMID:16258175 PMID:35908932 |
|
NCBI chr 6:21,093,927...21,103,091
|
|
G |
Ddb2 |
damage specific DNA binding protein 2 |
multiple interactions |
ISO |
pifithrin inhibits the reaction [benzo(a)pyrene diolepoxide I results in increased expression of DDB2 mRNA]; pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of DDB2 mRNA] |
CTD |
PMID:20064835 PMID:27694624 |
|
NCBI chr 3:77,185,114...77,207,650
|
|
G |
Dusp1 |
dual specificity phosphatase 1 |
multiple interactions |
ISO |
pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of DUSP1 mRNA] |
CTD |
PMID:20064835 |
|
NCBI chr10:17,184,853...17,187,646
|
|
G |
Edn1 |
endothelin 1 |
decreases expression multiple interactions |
ISO |
pifithrin results in decreased expression of EDN1 mRNA pifithrin inhibits the reaction [[KITLG protein co-treated with EDN1 protein] results in increased phosphorylation of TP53 protein] |
CTD |
PMID:19098008 |
|
NCBI chr17:22,660,799...22,666,687
|
|
G |
Ednrb |
endothelin receptor type B |
decreases expression |
ISO |
pifithrin results in decreased expression of EDNRB mRNA |
CTD |
PMID:19098008 |
|
NCBI chr15:87,055,490...87,086,765
|
|
G |
Ervfrd-1 |
endogenous retrovirus group FRD member 1, envelope |
multiple interactions |
ISO |
pifithrin inhibits the reaction [Benzo(a)pyrene results in increased expression of ERVFRD-1 mRNA] |
CTD |
PMID:24361490 |
|
NCBI chr12:22,151,211...22,158,264
|
|
G |
Fas |
Fas cell surface death receptor |
multiple interactions |
ISO EXP |
pifithrin inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of FAS protein]; pifithrin inhibits the reaction [Doxorubicin results in increased expression of FAS mRNA]; pifithrin inhibits the reaction [Doxorubicin results in increased expression of FAS protein] |
CTD |
PMID:11779855 PMID:16687611 PMID:26451628 |
|
NCBI chr 1:241,212,155...241,245,774
|
|
G |
Fdxr |
ferredoxin reductase |
multiple interactions |
ISO |
pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FDXR mRNA] |
CTD |
PMID:20064835 |
|
NCBI chr10:100,507,863...100,516,649
|
|
G |
Fosb |
FosB proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FOSB mRNA] |
CTD |
PMID:20064835 |
|
NCBI chr 1:88,082,324...88,089,506
|
|
G |
Fth1 |
ferritin heavy chain 1 |
multiple interactions |
ISO |
pifithrin inhibits the reaction [di-n-propyldithiocarbamate results in increased degradation of FTH1 protein] |
CTD |
PMID:32687844 |
|
NCBI chr 1:216,052,037...216,054,325
|
|
G |
Gadd45a |
growth arrest and DNA-damage-inducible, alpha |
multiple interactions |
ISO |
pifithrin inhibits the reaction [Excitatory Amino Acid Agents results in increased expression of GADD45A mRNA] pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of GADD45A mRNA] |
CTD |
PMID:20064835 PMID:20955365 |
|
NCBI chr 4:97,484,497...97,486,799
|
|
G |
Gdf15 |
growth differentiation factor 15 |
multiple interactions |
ISO |
pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of GDF15 mRNA] |
CTD |
PMID:20064835 |
|
NCBI chr16:18,838,436...18,842,022
|
|
G |
Glb1 |
galactosidase, beta 1 |
multiple interactions |
EXP |
pifithrin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of GLB1 protein] |
CTD |
PMID:33737050 |
|
NCBI chr 8:122,963,718...123,036,326
|
|
G |
Gpx4 |
glutathione peroxidase 4 |
multiple interactions |
EXP |
pifithrin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of GPX4 protein] |
CTD |
PMID:33737050 |
|
NCBI chr 7:10,300,833...10,303,629
|
|
G |
H2ax |
H2A.X variant histone |
multiple interactions |
ISO |
pifithrin promotes the reaction [2,4-dibromophenol metabolite results in increased expression of H2AX protein modified form]; pifithrin promotes the reaction [quinone analog results in increased expression of H2AX protein modified form] [pifithrin results in decreased phosphorylation of TP53 protein] inhibits the reaction [Oxaliplatin results in increased expression of H2AX protein modified form]; pifithrin inhibits the reaction [Decitabine results in increased phosphorylation of H2AX protein]; pifithrin promotes the reaction [Etoposide results in increased expression of H2AX protein]; pifithrin promotes the reaction [Mustard Gas results in increased phosphorylation of H2AX protein] |
CTD |
PMID:19732952 PMID:19735649 PMID:25448276 PMID:26259609 PMID:33961949 |
|
NCBI chr 8:53,568,718...53,570,072
|
|
G |
Ikbkb |
inhibitor of nuclear factor kappa B kinase subunit beta |
increases phosphorylation multiple interactions |
EXP |
pifithrin results in increased phosphorylation of IKBKB protein pifithrin inhibits the reaction [triptolide results in decreased phosphorylation of IKBKB protein] |
CTD |
PMID:31618665 |
|
NCBI chr16:76,021,968...76,075,717
|
|
G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
increases expression |
ISO |
pifithrin results in increased expression of JUN protein |
CTD |
PMID:16061640 |
|
NCBI chr 5:115,009,900...115,012,993
|
|
G |
Kit |
KIT proto-oncogene receptor tyrosine kinase |
decreases expression |
ISO |
pifithrin results in decreased expression of KIT mRNA |
CTD |
PMID:19098008 |
|
NCBI chr14:32,901,615...32,978,895
|
|
G |
Kitlg |
KIT ligand |
decreases expression multiple interactions |
ISO |
pifithrin results in decreased expression of KITLG mRNA pifithrin inhibits the reaction [[KITLG protein co-treated with EDN1 protein] results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [KITLG protein results in increased phosphorylation of TP53 protein] |
CTD |
PMID:19098008 |
|
NCBI chr 7:36,782,621...36,863,796
|
|
G |
Lasp1 |
LIM and SH3 protein 1 |
increases expression |
ISO |
pifithrin results in increased expression of LASP1 mRNA |
CTD |
PMID:28232485 |
|
NCBI chr10:83,290,820...83,331,989
|
|
G |
Ldha |
lactate dehydrogenase A |
multiple interactions |
ISO |
pifithrin inhibits the reaction [icaritin results in decreased expression of LDHA mRNA]; pifithrin inhibits the reaction [icaritin results in decreased expression of LDHA protein] |
CTD |
PMID:38431053 |
|
NCBI chr 1:97,371,823...97,381,247
|
|
G |
Lyz2 |
lysozyme 2 |
multiple interactions |
ISO |
pifithrin inhibits the reaction [Lipopolysaccharides results in increased expression of LYZ2 mRNA] |
CTD |
PMID:18550754 |
|
NCBI chr 7:52,906,810...52,912,154
|
|
G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions increases phosphorylation increases expression |
EXP ISO |
pifithrin inhibits the reaction [dibenzo(a,l)pyrene results in increased phosphorylation of MAPK1 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of MAPK1 protein] pifithrin results in increased phosphorylation of MAPK1 protein 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [pifithrin results in increased phosphorylation of MAPK1 protein]; pifithrin promotes the reaction [Doxorubicin results in increased phosphorylation of MAPK1 protein] pifithrin inhibits the reaction [Iron Compounds results in increased expression of MAPK1 protein modified form] pifithrin results in increased expression of MAPK1 protein modified form |
CTD |
PMID:12884365 PMID:16005925 PMID:16687611 PMID:28483490 |
|
NCBI chr11:97,462,025...97,529,193
|
|
G |
Mapk10 |
mitogen activated protein kinase 10 |
multiple interactions |
EXP |
pifithrin inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of MAPK10 protein] |
CTD |
PMID:16687611 |
|
NCBI chr14:6,802,247...7,094,103
|
|
G |
Mapk14 |
mitogen activated protein kinase 14 |
multiple interactions increases phosphorylation |
EXP ISO |
pifithrin inhibits the reaction [dibenzo(a,l)pyrene results in increased phosphorylation of MAPK14 protein] pifithrin results in increased phosphorylation of MAPK14 protein |
CTD |
PMID:16005925 PMID:16061640 |
|
NCBI chr20:6,751,288...6,812,294
|
|
G |
Mapk3 |
mitogen activated protein kinase 3 |
increases expression multiple interactions increases phosphorylation |
ISO EXP |
pifithrin results in increased expression of MAPK3 protein modified form pifithrin inhibits the reaction [Iron Compounds results in increased expression of MAPK3 protein modified form] 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [pifithrin results in increased phosphorylation of MAPK3 protein]; pifithrin promotes the reaction [Doxorubicin results in increased phosphorylation of MAPK3 protein] pifithrin inhibits the reaction [dibenzo(a,l)pyrene results in increased phosphorylation of MAPK3 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of MAPK3 protein] |
CTD |
PMID:12884365 PMID:16005925 PMID:16687611 PMID:28483490 |
|
NCBI chr 1:190,797,189...190,803,411
|
|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions increases phosphorylation |
ISO |
pifithrin inhibits the reaction [Silybin results in increased phosphorylation of MAPK8 protein] pifithrin results in increased phosphorylation of MAPK8 protein |
CTD |
PMID:16061640 PMID:16777994 |
|
NCBI chr16:8,645,171...8,728,225
|
|
G |
Mapk9 |
mitogen-activated protein kinase 9 |
multiple interactions |
ISO EXP |
pifithrin inhibits the reaction [Silybin results in increased phosphorylation of MAPK9 protein] pifithrin inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of MAPK9 protein] |
CTD |
PMID:16687611 PMID:16777994 |
|
NCBI chr10:34,670,750...34,711,972
|
|
G |
Mc1r |
melanocortin 1 receptor |
decreases expression |
ISO |
pifithrin results in decreased expression of MC1R mRNA |
CTD |
PMID:19098008 |
|
NCBI chr19:68,360,950...68,363,877
|
|
G |
Mdm2 |
MDM2 proto-oncogene |
multiple interactions |
EXP ISO |
pifithrin inhibits the reaction [Arsenic Trioxide results in increased expression of MDM2 mRNA] pifithrin inhibits the reaction [Doxorubicin results in increased expression of MDM2 mRNA]; pifithrin inhibits the reaction [Vehicle Emissions results in decreased expression of MDM2 protein] |
CTD |
PMID:14766674 PMID:17487067 PMID:18940243 |
|
NCBI chr 7:55,176,558...55,201,757
|
|
G |
Mitf |
melanocyte inducing transcription factor |
decreases expression |
ISO |
pifithrin results in decreased expression of MITF mRNA; pifithrin results in decreased expression of MITF protein |
CTD |
PMID:19098008 |
|
NCBI chr 4:131,965,676...132,177,790
|
|
G |
Mmp1 |
matrix metallopeptidase 1 |
multiple interactions |
ISO |
pifithrin inhibits the reaction [Etoposide results in decreased expression of MMP1 protein] |
CTD |
PMID:18557930 |
|
NCBI chr 8:12,943,453...12,963,966
|
|
G |
Mtor |
mechanistic target of rapamycin kinase |
increases expression multiple interactions |
ISO |
pifithrin results in increased expression of MTOR protein pifithrin inhibits the reaction [di-n-propyldithiocarbamate results in decreased expression of MTOR protein] |
CTD |
PMID:32687844 |
|
NCBI chr 5:164,167,985...164,277,438
|
|
G |
Ncoa4 |
nuclear receptor coactivator 4 |
multiple interactions decreases expression |
ISO |
pifithrin inhibits the reaction [di-n-propyldithiocarbamate results in increased expression of NCOA4 protein] pifithrin results in decreased expression of NCOA4 protein |
CTD |
PMID:32687844 |
|
NCBI chr16:7,395,502...7,415,846
|
|
G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO |
pifithrin results in increased activity of [NFKB1 protein binds to RELA protein] |
CTD |
PMID:16061640 |
|
NCBI chr 2:226,689,745...226,805,897
|
|
G |
Nfkbia |
NFKB inhibitor alpha |
increases phosphorylation |
EXP |
pifithrin results in increased phosphorylation of NFKBIA protein |
CTD |
PMID:31618665 |
|
NCBI chr 6:78,593,844...78,597,307
|
|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
EXP |
pifithrin inhibits the reaction [Benzo(a)pyrene results in increased expression of NOS2 protein] |
CTD |
PMID:26086121 |
|
NCBI chr10:64,313,335...64,349,221
|
|
G |
Notch1 |
notch receptor 1 |
multiple interactions |
ISO |
pifithrin inhibits the reaction [Cadmium Chloride results in increased cleavage of NOTCH1 protein] |
CTD |
PMID:25118938 |
|
NCBI chr 3:29,676,040...29,721,613
|
|
G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO EXP |
[pifithrin co-treated with Arsenic Trioxide] results in decreased expression of PARP1 protein; [pifithrin co-treated with Arsenic Trioxide] results in increased cleavage of PARP1 protein; [pifithrin results in increased susceptibility to Plant Preparations] which results in increased cleavage of PARP1 protein; pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [[Decitabine co-treated with Busulfan] results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [goniothalamin results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [Silybin results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [Simvastatin results in increased cleavage of PARP1 protein]; pifithrin promotes the reaction [Capsaicin results in increased cleavage of and results in increased activity of PARP1 protein]; pifithrin promotes the reaction [Mustard Gas results in increased cleavage of PARP1 protein] pifithrin inhibits the reaction [cordycepin results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [cyanoginosin LR results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein] |
CTD |
PMID:16687611 PMID:16777994 PMID:19732952 PMID:20045437 PMID:21810437 PMID:22226932 PMID:24704558 PMID:25448276 PMID:25939952 PMID:29698619 PMID:31157505 PMID:35022897 PMID:35030298 More...
|
|
NCBI chr13:94,839,484...94,871,295
|
|
G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions |
EXP |
pifithrin inhibits the reaction [Arsenic Trioxide results in increased expression of PCNA mRNA] |
CTD |
PMID:17487067 |
|
NCBI chr 3:139,951,948...139,955,820
|
|
G |
Pidd1 |
p53-induced death domain protein 1 |
multiple interactions |
ISO |
pifithrin inhibits the reaction [Cisplatin results in increased expression of PIDD1 mRNA] |
CTD |
PMID:15983031 |
|
NCBI chr 1:205,966,392...205,972,359
|
|
G |
Pkm |
pyruvate kinase M1/2 |
multiple interactions |
ISO |
pifithrin inhibits the reaction [icaritin results in decreased expression of PKM mRNA]; pifithrin inhibits the reaction [icaritin results in decreased expression of PKM protein] |
CTD |
PMID:38431053 |
|
NCBI chr 8:68,949,731...68,975,394
|
|
G |
Plk1 |
polo-like kinase 1 |
multiple interactions |
ISO |
[pifithrin co-treated with Paclitaxel] results in increased expression of PLK1 protein |
CTD |
PMID:18516295 |
|
NCBI chr 1:186,147,658...186,157,637
|
|
G |
Pmaip1 |
phorbol-12-myristate-13-acetate-induced protein 1 |
decreases expression multiple interactions |
ISO EXP |
pifithrin results in decreased expression of PMAIP1 protein pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased expression of PMAIP1 protein]; pifithrin inhibits the reaction [goniothalamin results in increased expression of PMAIP1 protein]; pifithrin inhibits the reaction [Simvastatin results in increased expression of PMAIP1 mRNA] pifithrin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PMAIP1 protein] |
CTD |
PMID:20045437 PMID:21810437 PMID:33031904 PMID:35022897 |
|
NCBI chr18:62,255,970...62,262,384
|
|
G |
Polh |
DNA polymerase eta |
multiple interactions |
ISO |
pifithrin inhibits the reaction [benzo(a)pyrene diolepoxide I results in increased expression of POLH mRNA]; pifithrin inhibits the reaction [fotemustine results in increased expression of POLH mRNA]; pifithrin inhibits the reaction [fotemustine results in increased expression of POLH protein]; pifithrin inhibits the reaction [Lomustine results in increased expression of POLH protein] |
CTD |
PMID:25125662 PMID:27694624 |
|
NCBI chr 9:14,778,355...14,813,210
|
|
G |
Prkaa1 |
protein kinase AMP-activated catalytic subunit alpha 1 |
multiple interactions |
ISO |
[pifithrin co-treated with Quercetin] results in increased phosphorylation of PRKAA1 protein |
CTD |
PMID:24535669 |
|
NCBI chr 2:55,967,766...56,003,450
|
|
G |
Prkdc |
protein kinase, DNA-activated, catalytic subunit |
multiple interactions |
ISO |
pifithrin inhibits the reaction [Capsaicin results in increased phosphorylation of PRKDC protein] |
CTD |
PMID:22226932 |
|
NCBI chr11:98,544,952...98,762,499
|
|
G |
Psen2 |
presenilin 2 |
multiple interactions |
ISO |
pifithrin inhibits the reaction [PSEN2 protein mutant form promotes the reaction [Staurosporine results in increased activity of CASP3 protein]] |
CTD |
PMID:12556443 |
|
NCBI chr13:94,499,451...94,528,419
|
|
G |
Pten |
phosphatase and tensin homolog |
multiple interactions |
ISO |
pifithrin inhibits the reaction [5-Methoxypsoralen results in increased expression of PTEN protein] |
CTD |
PMID:30576070 |
|
NCBI chr 1:240,043,707...240,110,330
|
|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
EXP |
pifithrin inhibits the reaction [Diquat results in increased expression of PTGS2 protein] |
CTD |
PMID:29484840 |
|
NCBI chr13:64,714,063...64,722,320
|
|
G |
Rad51 |
RAD51 recombinase |
multiple interactions |
ISO |
pifithrin inhibits the reaction [tetrachlorobenzoquinone results in decreased expression of RAD51 protein] |
CTD |
PMID:27989139 |
|
NCBI chr 3:126,554,210...126,578,888
|
|
G |
Raf1 |
Raf-1 proto-oncogene, serine/threonine kinase |
multiple interactions |
ISO |
[pifithrin co-treated with Paclitaxel] results in increased phosphorylation of RAF1 protein |
CTD |
PMID:18516295 |
|
NCBI chr 4:150,352,158...150,412,813
|
|
G |
Rb1 |
RB transcriptional corepressor 1 |
multiple interactions |
EXP |
pifithrin inhibits the reaction [Humic Substances results in decreased expression of RB1 protein] |
CTD |
PMID:18683188 |
|
NCBI chr15:54,780,858...54,911,989
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions increases expression |
EXP ISO |
pifithrin inhibits the reaction [Camptothecin inhibits the reaction [RELA protein binds to CREBBP protein]]; pifithrin inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]; pifithrin inhibits the reaction [triptolide results in decreased expression of RELA protein]; pifithrin promotes the reaction [RELA protein binds to CREBBP protein] pifithrin results in increased expression of RELA protein pifithrin results in increased activity of [NFKB1 protein binds to RELA protein] |
CTD |
PMID:12665479 PMID:13679428 PMID:16061640 PMID:31618665 |
|
NCBI chr 1:212,354,336...212,364,815
|
|
G |
S100a9 |
S100 calcium binding protein A9 |
multiple interactions |
EXP |
pifithrin inhibits the reaction [Isoproterenol results in increased expression of S100A9 protein] |
CTD |
PMID:32924446 |
|
NCBI chr 2:178,487,941...178,490,622
|
|
G |
Sesn1 |
sestrin 1 |
multiple interactions |
ISO |
pifithrin inhibits the reaction [sodium arsenite results in increased expression of SESN1 mRNA] |
CTD |
PMID:26148435 |
|
NCBI chr20:46,876,918...46,970,010
|
|
G |
Sesn2 |
sestrin 2 |
multiple interactions |
ISO |
[pifithrin co-treated with Arsenic Trioxide] results in increased expression of SESN2 mRNA; [pifithrin co-treated with Quercetin] results in increased expression of SESN2 protein pifithrin inhibits the reaction [Rotenone results in increased expression of SESN2 protein] |
CTD |
PMID:24535669 PMID:26031332 PMID:35030298 |
|
NCBI chr 5:149,986,304...150,005,255
|
|
G |
Slc2a1 |
solute carrier family 2 member 1 |
multiple interactions |
EXP ISO |
pifithrin inhibits the reaction [triptolide results in decreased expression of SLC2A1 protein] pifithrin inhibits the reaction [icaritin results in decreased expression of SLC2A1 mRNA]; pifithrin inhibits the reaction [icaritin results in decreased expression of SLC2A1 protein] |
CTD |
PMID:31618665 PMID:38431053 |
|
NCBI chr 5:138,002,522...138,030,742
|
|
G |
Slc2a4 |
solute carrier family 2 member 4 |
multiple interactions |
EXP |
pifithrin inhibits the reaction [triptolide results in decreased expression of SLC2A4 protein] |
CTD |
PMID:31618665 |
|
NCBI chr10:55,164,721...55,170,289
|
|
G |
Slc7a11 |
solute carrier family 7 member 11 |
multiple interactions |
EXP |
pifithrin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SLC7A11 protein] |
CTD |
PMID:33737050 |
|
NCBI chr 2:136,532,912...136,668,560
|
|
G |
Snai1 |
snail family transcriptional repressor 1 |
increases expression multiple interactions |
ISO |
pifithrin results in increased expression of SNAI1 protein pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SNAI1 mRNA] |
CTD |
PMID:20064835 PMID:32687844 |
|
NCBI chr 3:176,667,476...176,671,965
|
|
G |
Snai2 |
snail family transcriptional repressor 2 |
increases expression |
ISO |
pifithrin results in increased expression of SNAI2 protein |
CTD |
PMID:32687844 |
|
NCBI chr11:99,686,934...99,690,349
|
|
G |
Sod2 |
superoxide dismutase 2 |
multiple interactions |
ISO |
pifithrin inhibits the reaction [Rosiglitazone results in increased expression of SOD2 protein] |
CTD |
PMID:19226370 |
|
NCBI chr 1:50,043,323...50,050,168
|
|
G |
Sox30 |
SRY-box transcription factor 30 |
multiple interactions |
ISO |
pifithrin inhibits the reaction [SOX30 protein results in increased expression of TP53 mRNA]; pifithrin inhibits the reaction [SOX30 protein results in increased expression of TP53 protein] |
CTD |
PMID:25435374 |
|
NCBI chr10:30,417,499...30,446,441
|
|
G |
Star |
steroidogenic acute regulatory protein |
multiple interactions |
ISO |
pifithrin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of STAR protein] |
CTD |
PMID:32199951 |
|
NCBI chr16:72,969,824...72,974,447
|
|
G |
Tgfa |
transforming growth factor alpha |
multiple interactions decreases expression |
EXP |
TP53 protein affects the reaction [pifithrin results in decreased expression of TGFA protein] |
CTD |
PMID:12143041 |
|
NCBI chr 4:120,175,549...120,258,342
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP |
pifithrin inhibits the reaction [Diquat results in increased expression of TNF protein] |
CTD |
PMID:29484840 |
|
NCBI chr20:3,626,685...3,629,303
|
|
G |
Tp53 |
tumor protein p53 |
decreases activity decreases expression multiple interactions decreases phosphorylation affects expression |
EXP ISO |
pifithrin results in decreased activity of TP53 protein pifithrin results in decreased expression of TP53 mRNA; pifithrin results in decreased expression of TP53 protein pifithrin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TP53 protein]; pifithrin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TP53 protein]; pifithrin inhibits the reaction [APP protein alternative form results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Arsenic Trioxide results in increased activity of TP53 protein]; pifithrin inhibits the reaction [Camptothecin promotes the reaction [TP53 protein binds to CREBBP protein]]; pifithrin inhibits the reaction [Camptothecin results in increased activity of TP53 protein]; pifithrin inhibits the reaction [Cisplatin results in increased activity of TP53 protein]; pifithrin inhibits the reaction [cyanoginosin LR results in increased expression of TP53 protein]; pifithrin inhibits the reaction [dibenzo(a,l)pyrene results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Diquat results in increased expression of and affects the localization of TP53 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased expression of and results in increased localization of TP53 protein modified form]; pifithrin inhibits the reaction [Doxorubicin results in increased expression of and results in increased phosphorylation of and results in increased activity of TP53 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased localization of TP53 protein]; pifithrin inhibits the reaction [Isoproterenol results in increased expression of and results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Lipopolysaccharides results in increased localization of TP53 protein]; pifithrin inhibits the reaction [Ropivacaine results in increased expression of TP53 mRNA]; pifithrin inhibits the reaction [Ropivacaine results in increased expression of TP53 protein]; pifithrin inhibits the reaction [TP53 protein results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [TP53 protein results in increased susceptibility to Cisplatin]; pifithrin inhibits the reaction [triptolide results in increased expression of and results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [triptolide results in increased expression of TP53 protein modified form]; pifithrin inhibits the reaction [triptolide results in increased expression of TP53 protein]; pifithrin results in decreased expression of and results in decreased phosphorylation of TP53 protein; TP53 protein affects the reaction [pifithrin results in decreased expression of TGFA protein] pifithrin results in decreased phosphorylation of TP53 protein pifithrin affects the expression of TRP53 protein [pifithrin co-treated with cobaltous chloride] results in increased expression of and affects the localization of TP53 protein; [pifithrin results in decreased activity of TP53 protein] results in decreased susceptibility to [Oxaliplatin results in increased activity of CASP3 protein]; [pifithrin results in decreased activity of TP53 protein] which results in decreased susceptibility to Oxaliplatin; [pifithrin results in decreased phosphorylation of TP53 protein] inhibits the reaction [Oxaliplatin results in increased expression of H2AX protein modified form]; pifithrin inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of TP53 protein]; pifithrin inhibits the reaction [[Air Pollutants results in increased abundance of Benzo(a)pyrene] which results in increased expression of TP53 mRNA]; pifithrin inhibits the reaction [[KITLG protein co-treated with EDN1 protein] results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Asbestos, Amosite affects the localization of TP53 protein]; pifithrin inhibits the reaction [Asbestos, Amosite results in increased expression of TP53 protein]; pifithrin inhibits the reaction [Benzo(a)pyrene results in increased expression of TP53 protein]; pifithrin inhibits the reaction [Capsaicin results in increased phosphorylation of and results in increased activity of TP53 protein]; pifithrin inhibits the reaction [Celecoxib results in increased expression of TP53 protein]; pifithrin inhibits the reaction [Cisplatin results in increased expression of TP53 protein]; pifithrin inhibits the reaction [CITED2 mutant form promotes the reaction [Cisplatin results in increased expression of TP53 protein]]; pifithrin inhibits the reaction [di-n-propyldithiocarbamate results in increased expression of and results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Ellagic Acid promotes the reaction [Quercetin results in increased phosphorylation of TP53 protein]]; pifithrin inhibits the reaction [Etoposide results in increased activity of TP53 protein]; pifithrin inhibits the reaction [Gentian Violet promotes the reaction [TP53 protein results in increased expression of BAX mRNA]]; pifithrin inhibits the reaction [Gentian Violet promotes the reaction [TP53 protein results in increased expression of BBC3 mRNA]]; pifithrin inhibits the reaction [goniothalamin results in increased phosphorylation of and results in increased expression of TP53 protein]; pifithrin inhibits the reaction [KITLG protein results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [olaquindox results in decreased expression of TP53 protein]; pifithrin inhibits the reaction [Particulate Matter affects the localization of TRP53 protein]; pifithrin inhibits the reaction [Particulate Matter results in increased expression of TRP53 mRNA]; pifithrin inhibits the reaction [Particulate Matter results in increased expression of TRP53 protein]; pifithrin inhibits the reaction [Pyrroles analog results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Quercetin results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Reactive Oxygen Species affects the localization of TP53 protein]; pifithrin inhibits the reaction [Resveratrol results in increased expression of and results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Resveratrol results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Silybin results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Simvastatin results in increased expression of TP53 protein]; pifithrin inhibits the reaction [Smoke analog results in increased expression of TP53 mRNA]; pifithrin inhibits the reaction [SOX30 protein results in increased expression of TP53 mRNA]; pifithrin inhibits the reaction [SOX30 protein results in increased expression of TP53 protein]; pifithrin inhibits the reaction [TP53 protein promotes the reaction [chromium hexavalent ion results in decreased expression of BUB1B protein]]; pifithrin inhibits the reaction [TP53 protein results in increased susceptibility to Resveratrol]; pifithrin inhibits the reaction [TP53 protein results in increased susceptibility to trichostatin A]; pifithrin inhibits the reaction [TP53 results in increased susceptibility to Celecoxib]; pifithrin results in decreased expression of and results in decreased phosphorylation of TP53 protein; pifithrin results in decreased susceptibility to [Oxaliplatin results in increased expression of TP53 protein modified form]; pifithrin results in decreased susceptibility to [Oxaliplatin results in increased expression of TP53 protein] pifithrin results in decreased activity of TRP53 protein 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [pifithrin results in increased expression of and results in increased activity of TRP53 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [pifithrin results in increased expression of and results in increased activity of TRP53 protein]; [pifithrin results in decreased activity of TP53 protein] which results in decreased susceptibility to deoxynivalenol; [pifithrin results in decreased activity of TRP53 protein] inhibits the reaction [zearalenol affects the abundance of Reactive Oxygen Species]; [pifithrin results in decreased activity of TRP53 protein] which results in decreased susceptibility to zearalenol; pifithrin inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Cisplatin results in increased acetylation of TRP53 protein]]]; pifithrin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased phosphorylation of TRP53 protein]; pifithrin inhibits the reaction [Cisplatin results in increased acetylation of TRP53 protein]; pifithrin inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased expression of TRP53 protein]; pifithrin inhibits the reaction [deoxynivalenol results in increased phosphorylation of and results in increased activity of TRP53 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased expression of and results in increased phosphorylation of TRP53 protein]; pifithrin inhibits the reaction [Lipopolysaccharides results in increased expression of TRP53 mRNA]; pifithrin inhibits the reaction [Vanadates results in increased activity of TRP53 protein]; pifithrin inhibits the reaction [Vehicle Emissions results in increased phosphorylation of TRP53 protein]; pifithrin results in increased expression of and results in increased phosphorylation of and results in increased activity of TRP53 protein; TRP53 protein affects the reaction [pifithrin results in decreased expression of CDKN1A mRNA] |
CTD |
PMID:10702639 PMID:11279278 PMID:11889192 PMID:11914272 PMID:11931974 PMID:12143041 PMID:12413886 PMID:12665479 PMID:12884365 PMID:12893085 PMID:13679428 PMID:14766674 PMID:15144874 PMID:15315938 PMID:15735102 PMID:15976193 PMID:16005925 PMID:16087272 PMID:16258175 PMID:16357363 PMID:16467109 PMID:16687611 PMID:16777994 PMID:16814113 PMID:16882877 PMID:16946128 PMID:17487067 PMID:17670903 PMID:18364113 PMID:18550754 PMID:18775851 PMID:18940243 PMID:19098008 PMID:19706164 PMID:19735649 PMID:20045437 PMID:20708607 PMID:20878077 PMID:21593185 PMID:21660965 PMID:21810437 PMID:22226932 PMID:22491426 PMID:22886373 PMID:22983795 PMID:23152798 PMID:23376438 PMID:23380477 PMID:23665932 PMID:24535435 PMID:24567336 PMID:25435374 PMID:25956474 PMID:26259609 PMID:26884717 PMID:28757460 PMID:29484840 PMID:30009776 PMID:30543781 PMID:31157505 PMID:31618665 PMID:32540572 PMID:32687844 PMID:32924446 PMID:33031904 PMID:33737050 PMID:34091999 PMID:35908932 PMID:36982514 More...
|
|
NCBI chr10:54,798,871...54,810,300
|
|
G |
Tp53bp1 |
tumor protein p53 binding protein 1 |
multiple interactions |
ISO |
pifithrin inhibits the reaction [Etoposide results in increased expression of and affects the localization of TP53BP1 protein] |
CTD |
PMID:26259609 |
|
NCBI chr 3:108,166,574...108,270,229
|
|
G |
Tyr |
tyrosinase |
decreases expression |
ISO |
pifithrin results in decreased expression of TYR mRNA; pifithrin results in decreased expression of TYR protein |
CTD |
PMID:19098008 |
|
NCBI chr 1:150,527,687...150,622,857
|
|
G |
Usp8 |
ubiquitin specific peptidase 8 |
multiple interactions |
ISO |
pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased expression of BAX protein]; pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased expression of PMAIP1 protein] |
CTD |
PMID:35022897 |
|
NCBI chr 3:113,962,136...114,009,683
|
|
G |
Vim |
vimentin |
multiple interactions |
ISO |
pifithrin inhibits the reaction [di-n-propyldithiocarbamate results in decreased expression of VIM protein] |
CTD |
PMID:32687844 |
|
NCBI chr17:81,577,261...81,585,746
|
|
G |
Xiap |
X-linked inhibitor of apoptosis |
multiple interactions |
ISO |
[Topotecan co-treated with pifithrin] results in increased degradation of XIAP protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[pifithrin co-treated with Topotecan] results in increased degradation of XIAP protein] |
CTD |
PMID:19812371 |
|
NCBI chr X:125,756,107...125,803,979
|
|
G |
Xpc |
XPC complex subunit, DNA damage recognition and repair factor |
multiple interactions |
ISO |
pifithrin inhibits the reaction [benzo(a)pyrene diolepoxide I results in increased expression of XPC mRNA] |
CTD |
PMID:27694624 |
|
NCBI chr 4:123,993,670...124,020,922
|
|
|
G |
Slc5a5 |
solute carrier family 5 member 5 |
multiple interactions |
ISO |
sodium bromide inhibits the reaction [SLC5A5 protein results in increased uptake of perrhenate analog]; sodium bromide inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide analog]; sodium bromide inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Pertechnetate Tc 99m] |
CTD |
PMID:12488351 |
|
NCBI chr16:18,546,709...18,556,698
|
|
|
G |
Chrm1 |
cholinergic receptor, muscarinic 1 |
affects binding |
ISO |
Tiotropium Bromide binds to CHRM1 protein |
CTD |
PMID:21870878 |
|
NCBI chr 1:205,567,226...205,583,001
|
|
G |
Chrm2 |
cholinergic receptor, muscarinic 2 |
affects binding |
ISO |
Tiotropium Bromide binds to CHRM2 protein |
CTD |
PMID:21870878 |
|
NCBI chr 4:65,981,136...66,116,128
|
|
G |
Chrm3 |
cholinergic receptor, muscarinic 3 |
affects binding |
ISO |
Tiotropium Bromide binds to CHRM3 protein |
CTD |
PMID:21870878 |
|
NCBI chr17:64,696,549...65,158,622
|
|
G |
Chrm4 |
cholinergic receptor, muscarinic 4 |
affects binding |
ISO |
Tiotropium Bromide binds to CHRM4 protein |
CTD |
PMID:21870878 |
|
NCBI chr 3:98,349,080...98,356,821
|
|
G |
Chrm5 |
cholinergic receptor, muscarinic 5 |
affects binding |
ISO |
Tiotropium Bromide binds to CHRM5 protein |
CTD |
PMID:21870878 |
|
NCBI chr 3:99,284,846...99,337,252
|
|
G |
Edn1 |
endothelin 1 |
multiple interactions |
ISO |
Tiotropium Bromide inhibits the reaction [Oxotremorine results in increased expression of EDN1 mRNA] |
CTD |
PMID:22796455 |
|
NCBI chr17:22,660,799...22,666,687
|
|
G |
Pon1 |
paraoxonase 1 |
decreases activity |
ISO |
Tiotropium Bromide results in decreased activity of PON1 protein |
CTD |
PMID:31581362 |
|
NCBI chr 4:34,261,312...34,292,327
|
|
G |
Tnf |
tumor necrosis factor |
decreases secretion |
ISO |
Tiotropium Bromide results in decreased secretion of TNF protein |
CTD |
PMID:21352583 |
|
NCBI chr20:3,626,685...3,629,303
|
|
|
G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
decreases activity |
ISO |
thiaton results in decreased activity of KCNH2 protein |
CTD |
PMID:28551711 |
|
NCBI chr 4:11,719,357...11,751,424
|
|
G |
Mpo |
myeloperoxidase |
multiple interactions |
EXP |
thiaton inhibits the reaction [Indomethacin results in increased activity of MPO protein] |
CTD |
PMID:11855677 |
|
NCBI chr10:73,092,124...73,102,057
|
|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
EXP |
thiaton inhibits the reaction [Indomethacin results in increased activity of NOS2 protein] |
CTD |
PMID:11855677 |
|
NCBI chr10:64,313,335...64,349,221
|
|
|
G |
Abca1 |
ATP binding cassette subfamily A member 1 |
multiple interactions |
ISO |
Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCA1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCA1 protein] |
CTD |
PMID:30036686 |
|
NCBI chr 5:72,473,676...72,596,563
|
|
G |
Abcg1 |
ATP binding cassette subfamily G member 1 |
multiple interactions |
ISO |
Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCG1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCG1 protein] |
CTD |
PMID:30036686 |
|
NCBI chr20:9,128,056...9,184,312
|
|
G |
Chrm1 |
cholinergic receptor, muscarinic 1 |
multiple interactions |
ISO |
Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein] |
CTD |
PMID:9846649 |
|
NCBI chr 1:205,567,226...205,583,001
|
|
G |
Chrm2 |
cholinergic receptor, muscarinic 2 |
multiple interactions |
ISO |
Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM2 protein] |
CTD |
PMID:9846649 |
|
NCBI chr 4:65,981,136...66,116,128
|
|
G |
Chrm3 |
cholinergic receptor, muscarinic 3 |
multiple interactions |
ISO |
Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein] |
CTD |
PMID:9846649 |
|
NCBI chr17:64,696,549...65,158,622
|
|
G |
Chrm4 |
cholinergic receptor, muscarinic 4 |
multiple interactions |
ISO |
Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM4 protein] |
CTD |
PMID:9846649 |
|
NCBI chr 3:98,349,080...98,356,821
|
|
G |
Chrm5 |
cholinergic receptor, muscarinic 5 |
multiple interactions |
ISO |
Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein] |
CTD |
PMID:9846649 |
|
NCBI chr 3:99,284,846...99,337,252
|
|
G |
Chrna3 |
cholinergic receptor nicotinic alpha 3 subunit |
multiple interactions |
ISO |
Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]] |
CTD |
PMID:16931985 |
|
NCBI chr 8:55,401,668...55,415,165
|
|
G |
Chrna4 |
cholinergic receptor nicotinic alpha 4 subunit |
multiple interactions |
ISO |
Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Vecuronium Bromide results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] |
CTD |
PMID:14645658 PMID:16931985 |
|
NCBI chr 3:168,136,246...168,157,839
|
|
G |
Chrna7 |
cholinergic receptor nicotinic alpha 7 subunit |
multiple interactions |
ISO |
Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein] |
CTD |
PMID:16931985 |
|
NCBI chr 1:126,123,425...126,249,181
|
|
G |
Chrnb2 |
cholinergic receptor nicotinic beta 2 subunit |
multiple interactions |
ISO |
Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Vecuronium Bromide results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] |
CTD |
PMID:14645658 PMID:16931985 |
|
NCBI chr 2:175,181,402...175,189,619
|
|
G |
Chrnb4 |
cholinergic receptor nicotinic beta 4 subunit |
multiple interactions |
ISO |
Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]] |
CTD |
PMID:16931985 |
|
NCBI chr 8:55,417,583...55,437,027
|
|
G |
Cyp11a1 |
cytochrome P450, family 11, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP11A1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP11A1 protein] |
CTD |
PMID:31846720 |
|
NCBI chr 8:67,318,665...67,330,196
|
|
G |
Cyp19a1 |
cytochrome P450, family 19, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP19A1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP19A1 protein] |
CTD |
PMID:30959089 |
|
NCBI chr 8:63,449,148...63,476,534
|
|
G |
Egr1 |
early growth response 1 |
multiple interactions |
ISO |
Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of EGR1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of EGR1 protein] |
CTD |
PMID:29486207 |
|
NCBI chr18:26,737,078...26,740,877
|
|
G |
Elk1 |
ETS transcription factor ELK1 |
multiple interactions |
ISO |
Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of ELK1 protein] |
CTD |
PMID:29486207 |
|
NCBI chr X:3,692,367...3,709,252
|
|
G |
Hdac4 |
histone deacetylase 4 |
multiple interactions |
ISO |
Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 protein] |
CTD |
PMID:31846720 |
|
NCBI chr 9:99,950,972...100,200,994
|
|
G |
Hexb |
hexosaminidase subunit beta |
increases secretion |
ISO |
Vecuronium Bromide results in increased secretion of HEXB protein |
CTD |
PMID:19758318 |
|
NCBI chr 2:28,483,997...28,504,165
|
|
G |
Hsd11b2 |
hydroxysteroid 11-beta dehydrogenase 2 |
increases expression multiple interactions |
ISO |
Vecuronium Bromide results in increased expression of HSD11B2 mRNA; Vecuronium Bromide results in increased expression of HSD11B2 protein Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 protein] |
CTD |
PMID:29486207 |
|
NCBI chr19:50,307,569...50,312,812
|
|
G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:29486207 |
|
NCBI chr11:97,462,025...97,529,193
|
|
G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:29486207 |
|
NCBI chr 1:190,797,189...190,803,411
|
|
G |
Nr1h2 |
nuclear receptor subfamily 1, group H, member 2 |
multiple interactions |
ISO |
Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H2 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H2 protein] |
CTD |
PMID:30036686 |
|
NCBI chr 1:95,041,967...95,047,358
|
|
G |
Nr1h3 |
nuclear receptor subfamily 1, group H, member 3 |
multiple interactions |
ISO |
Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H3 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H3 protein] |
CTD |
PMID:30036686 |
|
NCBI chr 3:97,614,616...97,632,053
|
|
G |
Scarb1 |
scavenger receptor class B, member 1 |
multiple interactions |
ISO |
Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of SCARB1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of SCARB1 protein] |
CTD |
PMID:30036686 |
|
NCBI chr12:36,957,302...37,023,982
|
|
G |
Star |
steroidogenic acute regulatory protein |
multiple interactions |
ISO |
Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of STAR mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of STAR protein] |
CTD |
PMID:31846720 |
|
NCBI chr16:72,969,824...72,974,447
|
|