|
G |
Mc4r |
melanocortin 4 receptor |
increases activity |
ISO |
MSH, 4-Nle-7-Phe-alpha- results in increased activity of MC4R protein |
CTD |
PMID:17713970 |
|
NCBI chr18:60,419,832...60,421,719
Ensembl chr18:60,419,832...60,421,719
|
|
|
G |
Adam24 |
ADAM metallopeptidase domain 24 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of ADAM24 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr16:51,578,278...51,584,265
Ensembl chr16:51,578,277...51,584,312
|
|
G |
Adcyap1 |
adenylate cyclase activating polypeptide 1 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in decreased expression of ADCYAP1 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr 9:113,102,632...113,122,500
Ensembl chr 9:113,103,718...113,109,773
|
|
G |
Agt |
angiotensinogen |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of AGT mRNA |
CTD |
PMID:16635253 |
|
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
|
|
G |
Alas1 |
5'-aminolevulinate synthase 1 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of ALAS1 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917
|
|
G |
Alpl |
alkaline phosphatase, biomineralization associated |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in decreased expression of ALPL mRNA |
CTD |
PMID:16635253 |
|
NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
|
|
G |
Amhr2 |
anti-Mullerian hormone receptor type 2 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of AMHR2 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr 7:133,579,152...133,588,874
Ensembl chr 7:133,579,393...133,588,258
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|
G |
Anxa5 |
annexin A5 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in decreased expression of ANXA5 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369
|
|
G |
Arf3 |
ADP-ribosylation factor 3 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in decreased expression of ARF3 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr 7:129,886,082...129,912,022
Ensembl chr 7:129,886,082...129,912,002
|
|
G |
Btg1 |
BTG anti-proliferation factor 1 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of BTG1 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr 7:31,341,391...31,343,649
Ensembl chr 7:31,341,027...31,343,649
|
|
G |
Calb2 |
calbindin 2 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of CALB2 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr19:38,114,435...38,141,438
Ensembl chr19:38,114,424...38,141,438
|
|
G |
Camkk2 |
calcium/calmodulin-dependent protein kinase kinase 2 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of CAMKK2 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr12:33,791,023...33,845,000
Ensembl chr12:33,791,052...33,843,279
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|
G |
Car8 |
carbonic anhydrase 8 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of CAR8 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr 5:21,302,940...21,402,395
Ensembl chr 5:21,305,383...21,402,374
|
|
G |
Cck |
cholecystokinin |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in decreased expression of CCK mRNA |
CTD |
PMID:16635253 |
|
NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084
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|
G |
Cd63 |
Cd63 molecule |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of CD63 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr 7:1,325,108...1,340,447
Ensembl chr 7:1,325,103...1,399,178
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|
G |
Cdh15 |
cadherin 15 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of CDH15 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr19:50,903,757...50,927,151
Ensembl chr19:50,903,638...50,927,105
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|
G |
Chd7 |
chromodomain helicase DNA binding protein 7 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of CHD7 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr 5:21,812,007...21,995,358
Ensembl chr 5:21,812,070...21,995,358
|
|
G |
Cited2 |
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of CITED2 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897
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|
G |
Col18a1 |
collagen type XVIII alpha 1 chain |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of COL18A1 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr20:11,474,104...11,582,593
Ensembl chr20:11,474,104...11,582,593
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|
G |
Csrp2 |
cysteine and glycine-rich protein 2 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in decreased expression of CSRP2 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr 7:46,349,109...46,367,743
Ensembl chr 7:46,348,686...46,367,745
|
|
G |
Cyfip2 |
cytoplasmic FMR1 interacting protein 2 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in decreased expression of CYFIP2 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr10:30,621,318...30,741,113
Ensembl chr10:30,621,318...30,741,113
|
|
G |
Dao |
D-amino-acid oxidase |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of DAO mRNA |
CTD |
PMID:16635253 |
|
NCBI chr12:42,592,342...42,613,046
Ensembl chr12:42,592,343...42,612,741
|
|
G |
Dgkg |
diacylglycerol kinase, gamma |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of DGKG mRNA |
CTD |
PMID:16635253 |
|
NCBI chr11:78,384,212...78,579,158
Ensembl chr11:78,384,458...78,577,212
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|
G |
Dusp5 |
dual specificity phosphatase 5 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of CPG21 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818
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|
G |
Fat1 |
FAT atypical cadherin 1 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of FAT1 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr16:47,177,253...47,296,261
Ensembl chr16:47,177,248...47,296,107
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|
G |
Fxyd1 |
FXYD domain-containing ion transport regulator 1 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of FXYD1 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr 1:86,287,163...86,291,478
Ensembl chr 1:86,287,165...86,291,278
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|
G |
Gabra6 |
gamma-aminobutyric acid type A receptor subunit alpha6 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of GABRA6 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr10:26,810,411...26,825,768
Ensembl chr10:26,810,423...26,825,769
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|
G |
Gabrd |
gamma-aminobutyric acid type A receptor subunit delta |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of GABRD mRNA |
CTD |
PMID:16635253 |
|
NCBI chr 5:165,958,508...165,970,407
Ensembl chr 5:165,958,484...165,970,411
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|
G |
Gfra2 |
GDNF family receptor alpha 2 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in decreased expression of GFRA2 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr15:45,941,841...46,033,715
Ensembl chr15:45,941,828...46,033,714
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|
G |
Grid2 |
glutamate ionotropic receptor delta type subunit 2 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of GRID2 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr 4:92,415,019...93,892,472
Ensembl chr 4:92,415,230...93,889,355
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|
G |
Grm1 |
glutamate metabotropic receptor 1 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of GRM1 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr 1:5,058,285...5,453,170
Ensembl chr 1:5,058,292...5,453,170
|
|
G |
Grm4 |
glutamate metabotropic receptor 4 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of GRM4 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr20:5,484,172...5,572,821
Ensembl chr20:5,481,124...5,572,821
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|
G |
H1f0 |
H1.0 linker histone |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of H1F0 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr 7:110,592,834...110,594,694
Ensembl chr 7:110,592,208...110,594,694
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|
G |
H1f4 |
H1.4 linker histone, cluster member |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of H1F4 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr17:41,486,574...41,487,355
Ensembl chr17:41,486,560...41,487,403
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|
G |
Hpcal1 |
hippocalcin-like 1 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of HPCAL1 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr 6:40,478,206...40,584,721
Ensembl chr 6:40,478,208...40,584,687
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|
G |
Igf2 |
insulin-like growth factor 2 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of IGF2 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018
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|
G |
Igfbp2 |
insulin-like growth factor binding protein 2 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of IGFBP2 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937
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|
G |
Kcnc1 |
potassium voltage-gated channel subfamily C member 1 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of KCNC1 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr 1:96,902,953...96,944,744
Ensembl chr 1:96,902,953...96,944,744
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|
G |
Kcnj12 |
potassium inwardly-rectifying channel, subfamily J, member 12 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of KCNJ12 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr10:45,696,621...45,745,528
Ensembl chr10:45,696,849...45,745,492
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|
G |
Kcnmb4 |
potassium calcium-activated channel subfamily M regulatory beta subunit 4 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in decreased expression of KCNMB4 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr 7:52,066,145...52,119,098
Ensembl chr 7:52,066,136...52,119,278
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|
G |
Kif13a |
kinesin family member 13A |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of KIF13A mRNA |
CTD |
PMID:16635253 |
|
NCBI chr17:17,766,597...17,948,517
Ensembl chr17:17,766,597...17,943,615
|
|
G |
Kifc2 |
kinesin family member C2 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in decreased expression of KIFC2 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr 7:108,380,634...108,388,364
Ensembl chr 7:108,376,011...108,388,484
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|
G |
Klk6 |
kallikrein related-peptidase 6 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of KLK6 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr 1:94,278,863...94,286,136
Ensembl chr 1:94,280,340...94,286,121
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|
G |
Lgals1 |
galectin 1 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of LGALS1 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr 7:110,485,239...110,488,345
Ensembl chr 7:110,481,392...110,488,345
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|
G |
Lzts1 |
leucine zipper tumor suppressor 1 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in decreased expression of LZTS1 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr16:20,542,756...20,598,204
Ensembl chr16:20,542,809...20,598,203
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|
G |
Mab21l2 |
mab-21 like 2 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of MAB21L2 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr 2:171,946,573...171,949,655
Ensembl chr 2:171,946,573...171,949,655
|
|
G |
Nefh |
neurofilament heavy chain |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of NEFH mRNA |
CTD |
PMID:16635253 |
|
NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
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G |
Neurod1 |
neuronal differentiation 1 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of NEUROD1 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr 3:64,359,554...64,363,526
Ensembl chr 3:64,359,395...64,363,649
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|
G |
Nrep |
neuronal regeneration related protein |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of NREP mRNA |
CTD |
PMID:16635253 |
|
NCBI chr18:25,017,069...25,046,593
Ensembl chr18:25,017,083...25,046,591
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G |
Nsmf |
NMDA receptor synaptonuclear signaling and neuronal migration factor |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in decreased expression of NSMF mRNA |
CTD |
PMID:16635253 |
|
NCBI chr 3:7,861,846...7,870,615
Ensembl chr 3:7,861,872...7,870,614
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G |
Patj |
PATJ, crumbs cell polarity complex component |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of PATJ mRNA |
CTD |
PMID:16635253 |
|
NCBI chr 5:113,061,985...113,364,807
Ensembl chr 5:113,062,118...113,364,807
|
|
G |
Pcsk6 |
proprotein convertase subtilisin/kexin type 6 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of PCSK6 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr 1:119,428,978...119,627,626
Ensembl chr 1:119,429,265...119,627,596
|
|
G |
Pde2a |
phosphodiesterase 2A |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in decreased expression of PDE2A mRNA |
CTD |
PMID:16635253 |
|
NCBI chr 1:155,823,590...155,915,434
Ensembl chr 1:155,813,180...155,915,434
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|
G |
Per2 |
period circadian regulator 2 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in decreased expression of PER2 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459
|
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G |
Pex6 |
peroxisomal biogenesis factor 6 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of PEX6 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr 9:14,258,145...14,270,335
Ensembl chr 9:14,258,145...14,270,303
|
|
G |
Ppm1d |
protein phosphatase, Mg2+/Mn2+ dependent, 1D |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of PPM1D mRNA |
CTD |
PMID:16635253 |
|
NCBI chr10:70,172,603...70,208,607
Ensembl chr10:70,172,603...70,208,607
|
|
G |
Ptgds |
prostaglandin D2 synthase |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of PTGDS mRNA |
CTD |
PMID:16635253 |
|
NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833
|
|
G |
Ptgfrn |
prostaglandin F2 receptor inhibitor |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in decreased expression of PTGFRN mRNA |
CTD |
PMID:16635253 |
|
NCBI chr 2:188,469,521...188,544,795
Ensembl chr 2:188,469,521...188,544,795
|
|
G |
Ptk2b |
protein tyrosine kinase 2 beta |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in decreased expression of PTK2B mRNA |
CTD |
PMID:16635253 |
|
NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282
|
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G |
Ptpn5 |
protein tyrosine phosphatase, non-receptor type 5 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in decreased expression of PTPN5 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr 1:97,620,638...97,681,186
Ensembl chr 1:97,620,642...97,679,882
|
|
G |
Ptprr |
protein tyrosine phosphatase, receptor type, R |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of PTPRR mRNA |
CTD |
PMID:16635253 |
|
NCBI chr 7:51,662,595...51,929,605
Ensembl chr 7:51,662,595...51,929,603
|
|
G |
Pvalb |
parvalbumin |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of PVALB mRNA |
CTD |
PMID:16635253 |
|
NCBI chr 7:109,772,939...109,787,954
Ensembl chr 7:109,772,593...109,784,561
|
|
G |
Rbp4 |
retinol binding protein 4 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of RBP mRNA |
CTD |
PMID:16635253 |
|
NCBI chr 1:235,893,917...235,901,315
Ensembl chr 1:235,893,917...235,901,399
|
|
G |
Rgs12 |
regulator of G-protein signaling 12 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in decreased expression of RGS12 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr14:75,715,925...75,824,012
Ensembl chr14:75,715,934...75,794,596
|
|
G |
Rgs3 |
regulator of G-protein signaling 3 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of RGS3 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr 5:76,022,038...76,161,895
Ensembl chr 5:76,022,001...76,161,894
|
|
G |
Rgs4 |
regulator of G-protein signaling 4 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in decreased expression of RGS4 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068
|
|
G |
Rpl24 |
ribosomal protein L24 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of RPL24 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr11:44,653,937...44,659,346
Ensembl chr11:44,653,937...44,659,370
|
|
G |
Rps6ka1 |
ribosomal protein S6 kinase A1 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of RPS6KA1 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr 5:146,079,018...146,118,272
Ensembl chr 5:146,079,021...146,118,272
|
|
G |
Sdc1 |
syndecan 1 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of SDC1 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr 6:31,562,799...31,585,267
Ensembl chr 6:31,562,739...31,585,264
|
|
G |
Sh3bp5 |
SH3-domain binding protein 5 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of SH3BP5 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr16:6,583,462...6,678,344
Ensembl chr16:6,583,465...6,698,975
|
|
G |
Slc1a6 |
solute carrier family 1 member 6 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of SLC1A6 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr 7:10,841,836...10,870,424
Ensembl chr 7:10,841,837...10,870,449
|
|
G |
Smpd3 |
sphingomyelin phosphodiesterase 3 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in decreased expression of SMPD3 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr19:34,162,337...34,245,786
Ensembl chr19:34,162,341...34,245,749
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|
G |
Sparc |
secreted protein acidic and cysteine rich |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of SPARC mRNA |
CTD |
PMID:16635253 |
|
NCBI chr10:39,516,394...39,538,252
Ensembl chr10:39,516,406...39,538,396
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|
G |
Spp1 |
secreted phosphoprotein 1 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of SPP1 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
|
|
G |
Sstr1 |
somatostatin receptor 1 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in decreased expression of SSTR1 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr 6:75,832,292...75,836,806
Ensembl chr 6:75,832,530...75,836,802
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|
G |
Sstr3 |
somatostatin receptor 3 |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of SSTR3 mRNA |
CTD |
PMID:16635253 |
|
NCBI chr 7:110,092,563...110,109,043
Ensembl chr 7:110,092,575...110,099,769
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|
G |
Tf |
transferrin |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of TF mRNA |
CTD |
PMID:16635253 |
|
NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
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|
G |
Ttr |
transthyretin |
multiple interactions |
EXP |
[ampullosporin co-treated with Ketamine] results in increased expression of TTR mRNA |
CTD |
PMID:16635253 |
|
NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008
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|
|
G |
Agt |
angiotensinogen |
multiple interactions |
EXP |
[astressin co-treated with AGT protein] results in increased phosphorylation of FOS protein; [astressin co-treated with AGT protein] results in increased phosphorylation of MAPK1 protein; [astressin co-treated with AGT protein] results in increased phosphorylation of MAPK3 protein; [IL1RN protein co-treated with astressin] promotes the reaction [AGT protein results in increased expression of CRH protein]; [IL1RN protein co-treated with astressin] promotes the reaction [AGT protein results in increased expression of FOS protein]; [IL1RN protein co-treated with astressin] promotes the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; [IL1RN protein co-treated with astressin] promotes the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]; astressin promotes the reaction [AGT protein results in increased expression of CRH protein] |
CTD |
PMID:33872574 |
|
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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|
G |
Crh |
corticotropin releasing hormone |
multiple interactions |
EXP |
[IL1RN protein co-treated with astressin] promotes the reaction [AGT protein results in increased expression of CRH protein]; astressin promotes the reaction [AGT protein results in increased expression of CRH protein] |
CTD |
PMID:33872574 |
|
NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
|
|
G |
Crhr1 |
corticotropin releasing hormone receptor 1 |
multiple interactions |
ISO |
astressin binds to and results in decreased activity of CRHR1 protein |
CTD |
PMID:16014403 |
|
NCBI chr10:89,040,186...89,083,481
Ensembl chr10:89,040,203...89,083,481
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|
G |
Crhr2 |
corticotropin releasing hormone receptor 2 |
multiple interactions |
ISO |
astressin binds to and results in decreased activity of CRHR2 protein |
CTD |
PMID:16014403 |
|
NCBI chr 4:84,222,897...84,265,924
Ensembl chr 4:84,224,002...84,265,904
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|
G |
Cyp11a1 |
cytochrome P450, family 11, subfamily a, polypeptide 1 |
decreases expression |
ISO |
astressin results in decreased expression of CYP11A1 mRNA |
CTD |
PMID:16014403 |
|
NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
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|
G |
Cyp17a1 |
cytochrome P450, family 17, subfamily a, polypeptide 1 |
decreases expression |
ISO |
astressin results in decreased expression of CYP17A1 mRNA |
CTD |
PMID:16014403 |
|
NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
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|
G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
EXP |
[astressin co-treated with AGT protein] results in increased phosphorylation of FOS protein; [IL1RN protein co-treated with astressin] promotes the reaction [AGT protein results in increased expression of FOS protein] |
CTD |
PMID:33872574 |
|
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
|
|
G |
Il1rn |
interleukin 1 receptor antagonist |
multiple interactions |
EXP |
[IL1RN protein co-treated with astressin] promotes the reaction [AGT protein results in increased expression of CRH protein]; [IL1RN protein co-treated with astressin] promotes the reaction [AGT protein results in increased expression of FOS protein]; [IL1RN protein co-treated with astressin] promotes the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; [IL1RN protein co-treated with astressin] promotes the reaction [AGT protein results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:33872574 |
|
NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
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|
G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
EXP |
[astressin co-treated with AGT protein] results in increased phosphorylation of MAPK1 protein; [IL1RN protein co-treated with astressin] promotes the reaction [AGT protein results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:33872574 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
|
|
G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
EXP |
[astressin co-treated with AGT protein] results in increased phosphorylation of MAPK3 protein; [IL1RN protein co-treated with astressin] promotes the reaction [AGT protein results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:33872574 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
|
|
G |
Star |
steroidogenic acute regulatory protein |
decreases expression |
ISO |
astressin results in decreased expression of STAR mRNA |
CTD |
PMID:16014403 |
|
NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
|
|
G |
Sult2a1 |
sulfotransferase family 2A member 1 |
decreases expression |
ISO |
astressin results in decreased expression of SULT2A1 mRNA |
CTD |
PMID:16014403 |
|
NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134
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G |
Ucn |
urocortin |
multiple interactions decreases response to substance |
EXP |
astressin inhibits the reaction [UCN protein inhibits the reaction [Thapsigargin results in increased uptake of Calcium]]; astressin inhibits the reaction [UCN protein inhibits the reaction [Thapsigargin results in increased uptake of Manganese]] astressin results in decreased susceptibility to UCN protein |
CTD |
PMID:17885217 PMID:20237592 |
|
NCBI chr 6:25,238,120...25,238,950
Ensembl chr 6:25,238,120...25,238,950
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|
|
G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO |
astressin-2B inhibits the reaction [tcdA protein, Clostridium difficile results in increased expression of CCL2 mRNA] |
CTD |
PMID:16920976 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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|
G |
Cxcl3 |
C-X-C motif chemokine ligand 3 |
multiple interactions |
ISO |
astressin-2B inhibits the reaction [tcdA protein, Clostridium difficile results in increased expression of CXCL1 mRNA] |
CTD |
PMID:16920976 |
|
NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
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|
G |
Il6 |
interleukin 6 |
multiple interactions |
EXP |
astressin-2B promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] |
CTD |
PMID:12746300 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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|
G |
Pomc |
proopiomelanocortin |
increases secretion |
EXP |
astressin-2B results in increased secretion of POMC protein alternative form |
CTD |
PMID:12746300 |
|
NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
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|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP |
astressin-2B promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein] |
CTD |
PMID:12746300 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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|
G |
Ucn |
urocortin |
decreases activity |
EXP |
astressin-2B results in decreased activity of UCN protein |
CTD |
PMID:12010772 |
|
NCBI chr 6:25,238,120...25,238,950
Ensembl chr 6:25,238,120...25,238,950
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|
|
G |
A2m |
alpha-2-macroglobulin |
increases expression |
EXP |
Bacitracin results in increased expression of A2M mRNA |
CTD |
PMID:18289764 |
|
NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786
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|
G |
Ache |
acetylcholinesterase |
multiple interactions |
ISO |
Bacitracin binds to and results in decreased metabolism of and results in decreased secretion of ACHE protein |
CTD |
PMID:23047022 |
|
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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|
G |
Aldh1a1 |
aldehyde dehydrogenase 1 family, member A1 |
increases expression |
EXP |
Bacitracin results in increased expression of ALDH1A1 mRNA |
CTD |
PMID:18289764 |
|
NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
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G |
Anxa5 |
annexin A5 |
increases expression |
EXP |
Bacitracin results in increased expression of ANXA5 mRNA |
CTD |
PMID:18289764 |
|
NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369
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G |
Bmp1 |
bone morphogenetic protein 1 |
increases expression |
EXP |
Bacitracin results in increased expression of BMP1 mRNA |
CTD |
PMID:18289764 |
|
NCBI chr15:45,551,603...45,595,862
Ensembl chr15:45,551,603...45,595,776
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|
G |
Bmp4 |
bone morphogenetic protein 4 |
decreases expression |
EXP |
Bacitracin results in decreased expression of BMP4 mRNA |
CTD |
PMID:18289764 |
|
NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
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|
G |
Calb1 |
calbindin 1 |
decreases expression |
EXP |
Bacitracin results in decreased expression of CALB1 mRNA |
CTD |
PMID:18289764 |
|
NCBI chr 5:29,375,624...29,402,532
Ensembl chr 5:29,375,642...29,402,431
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G |
Cat |
catalase |
decreases expression |
EXP |
Bacitracin results in decreased expression of CAT mRNA |
CTD |
PMID:18289764 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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|
G |
Ccn1 |
cellular communication network factor 1 |
affects expression |
EXP |
Bacitracin affects the expression of CCN1 mRNA |
CTD |
PMID:18289764 |
|
NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
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|
G |
Ccnd1 |
cyclin D1 |
increases expression |
EXP |
Bacitracin results in increased expression of CCND1 mRNA |
CTD |
PMID:18289764 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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|
G |
Ccng1 |
cyclin G1 |
increases expression |
EXP |
Bacitracin results in increased expression of CCNG1 mRNA |
CTD |
PMID:18289764 |
|
NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641
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|
G |
Cd24 |
CD24 molecule |
increases expression |
EXP |
Bacitracin results in increased expression of CD24 mRNA |
CTD |
PMID:18289764 |
|
NCBI chr20:47,074,353...47,079,662
Ensembl chr20:47,073,512...47,079,662
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|
G |
Cd44 |
CD44 molecule |
increases expression |
EXP |
Bacitracin results in increased expression of CD44 mRNA |
CTD |
PMID:18289764 |
|
NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
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|
G |
Clu |
clusterin |
increases expression |
EXP |
Bacitracin results in increased expression of CLU mRNA |
CTD |
PMID:18289764 |
|
NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
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|
G |
Cp |
ceruloplasmin |
increases expression |
EXP |
Bacitracin results in increased expression of CP mRNA |
CTD |
PMID:18289764 |
|
NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075
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|
G |
Ctss |
cathepsin S |
increases expression |
EXP |
Bacitracin results in increased expression of CTSS mRNA |
CTD |
PMID:18289764 |
|
NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483
|
|
G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
decreases expression |
EXP |
Bacitracin results in decreased expression of CYP2D22 mRNA |
CTD |
PMID:18289764 |
|
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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|
G |
Egf |
epidermal growth factor |
decreases expression |
EXP |
Bacitracin results in decreased expression of EGF mRNA |
CTD |
PMID:18289764 |
|
NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
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|
G |
Fn1 |
fibronectin 1 |
increases expression |
EXP |
Bacitracin results in increased expression of FN1 mRNA |
CTD |
PMID:18289764 |
|
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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|
G |
G6pc1 |
glucose-6-phosphatase catalytic subunit 1 |
decreases expression |
EXP |
Bacitracin results in decreased expression of G6PC1 mRNA |
CTD |
PMID:18289764 |
|
NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
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G |
Gadd45a |
growth arrest and DNA-damage-inducible, alpha |
increases expression |
EXP |
Bacitracin results in increased expression of GADD45A mRNA |
CTD |
PMID:18289764 |
|
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
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|
G |
Ghr |
growth hormone receptor |
affects expression |
EXP |
Bacitracin affects the expression of GHR mRNA |
CTD |
PMID:18289764 |
|
NCBI chr 2:52,541,452...52,804,960
Ensembl chr 2:52,542,594...52,804,735
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|
G |
Glul |
glutamate-ammonia ligase |
increases expression |
EXP |
Bacitracin results in increased expression of GLUL mRNA |
CTD |
PMID:18289764 |
|
NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108
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G |
Gstm2 |
glutathione S-transferase mu 2 |
increases expression |
EXP |
Bacitracin results in increased expression of GSTM2 mRNA |
CTD |
PMID:18289764 |
|
NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
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|
G |
Havcr1 |
hepatitis A virus cellular receptor 1 |
increases expression |
EXP |
Bacitracin results in increased expression of HAVCR1 mRNA |
CTD |
PMID:18289764 |
|
NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
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|
G |
Hmox1 |
heme oxygenase 1 |
increases expression |
EXP |
Bacitracin results in increased expression of HMOX1 mRNA |
CTD |
PMID:18289764 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hmox2 |
heme oxygenase 2 |
increases expression |
EXP |
Bacitracin results in increased expression of HMOX2 mRNA |
CTD |
PMID:18289764 |
|
NCBI chr10:10,797,076...10,831,178
Ensembl chr10:10,797,055...10,831,148
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G |
Igfbp1 |
insulin-like growth factor binding protein 1 |
increases expression |
EXP |
Bacitracin results in increased expression of IGFBP1 mRNA |
CTD |
PMID:18289764 |
|
NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
|
|
G |
Igkc |
immunoglobulin kappa constant |
decreases expression increases expression |
EXP |
Bacitracin results in decreased expression of IGKC mRNA Bacitracin results in increased expression of IGKC mRNA |
CTD |
PMID:18289764 |
|
|
|
G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
increases expression |
EXP |
Bacitracin results in increased expression of JUN mRNA |
CTD |
PMID:18289764 |
|
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
|
|
G |
Klk1b3 |
kallikrein 1-related peptidase B3 |
decreases expression |
EXP |
Bacitracin results in decreased expression of NGFG mRNA |
CTD |
PMID:18289764 |
|
NCBI chr 1:94,709,105...94,713,308
Ensembl chr 1:94,709,105...94,713,308
|
|
G |
Lcn2 |
lipocalin 2 |
increases expression |
EXP |
Bacitracin results in increased expression of LCN2 mRNA |
CTD |
PMID:18289764 |
|
NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
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|
G |
Mgp |
matrix Gla protein |
increases expression |
EXP |
Bacitracin results in increased expression of MGP mRNA |
CTD |
PMID:18289764 |
|
NCBI chr 4:169,766,290...169,769,612
Ensembl chr 4:169,766,279...169,769,667
|
|
G |
Mt1 |
metallothionein 1 |
increases expression |
EXP |
Bacitracin results in increased expression of MT1A mRNA |
CTD |
PMID:18289764 |
|
NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049 Ensembl chr17:10,826,032...10,827,049
|
|
G |
Nphs2 |
NPHS2 stomatin family member, podocin |
decreases expression |
EXP |
Bacitracin results in decreased expression of NPHS2 mRNA |
CTD |
PMID:18289764 |
|
NCBI chr13:68,448,720...68,461,312
Ensembl chr13:68,448,926...68,461,313
|
|
G |
Oat |
ornithine aminotransferase |
increases expression |
EXP |
Bacitracin results in increased expression of OAT mRNA |
CTD |
PMID:18289764 |
|
NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682
|
|
G |
Rgn |
regucalcin |
decreases expression |
EXP |
Bacitracin results in decreased expression of RGN mRNA |
CTD |
PMID:18289764 |
|
NCBI chr X:1,619,030...1,634,456
Ensembl chr X:1,619,032...1,634,450
|
|
G |
Slc22a1 |
solute carrier family 22 member 1 |
decreases expression |
EXP |
Bacitracin results in decreased expression of SLC22A1 mRNA |
CTD |
PMID:18289764 |
|
NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
|
|
G |
Slc22a6 |
solute carrier family 22 member 6 |
decreases expression |
EXP |
Bacitracin results in decreased expression of SLC22A6 mRNA |
CTD |
PMID:18289764 |
|
NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
|
|
G |
Spp1 |
secreted phosphoprotein 1 |
increases expression |
EXP |
Bacitracin results in increased expression of SPP1 mRNA |
CTD |
PMID:18289764 |
|
NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
|
|
G |
Timp1 |
TIMP metallopeptidase inhibitor 1 |
increases expression |
EXP |
Bacitracin results in increased expression of TIMP1 mRNA |
CTD |
PMID:18289764 |
|
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
|
|
G |
Tmsb10 |
thymosin, beta 10 |
increases expression |
EXP |
Bacitracin results in increased expression of TMSB10 mRNA |
CTD |
PMID:18289764 |
|
NCBI chr 4:105,009,959...105,011,095
Ensembl chr 4:105,009,212...105,011,028
|
|
G |
Vcam1 |
vascular cell adhesion molecule 1 |
increases expression |
EXP |
Bacitracin results in increased expression of VCAM1 mRNA |
CTD |
PMID:18289764 |
|
NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
|
|
G |
Vegfa |
vascular endothelial growth factor A |
decreases expression |
EXP |
Bacitracin results in decreased expression of VEGFA mRNA |
CTD |
PMID:18289764 |
|
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
|
|
G |
Vim |
vimentin |
increases expression |
EXP |
Bacitracin results in increased expression of VIM mRNA |
CTD |
PMID:18289764 |
|
NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
|
|
|
G |
Agt |
angiotensinogen |
increases abundance multiple interactions |
EXP |
AGT protein results in increased abundance of beta-Endorphin IL1RN protein inhibits the reaction [AGT protein results in increased abundance of beta-Endorphin] |
CTD |
PMID:33872574 |
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NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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G |
Crh |
corticotropin releasing hormone |
decreases secretion increases secretion multiple interactions |
EXP |
beta-Endorphin results in decreased secretion of CRH protein CRF protein results in increased secretion of beta-Endorphin adinazolam inhibits the reaction [CRF protein results in increased secretion of beta-Endorphin]; beta-Endorphin inhibits the reaction [Nitroprusside results in increased secretion of CRH protein]; Naltrexone inhibits the reaction [beta-Endorphin results in decreased secretion of CRH protein] |
CTD |
PMID:1480515 PMID:3031743 |
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NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
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G |
Il1rn |
interleukin 1 receptor antagonist |
multiple interactions |
EXP |
IL1RN protein inhibits the reaction [AGT protein results in increased abundance of beta-Endorphin] |
CTD |
PMID:33872574 |
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NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
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G |
Il2 |
interleukin 2 |
decreases expression |
ISO |
beta-Endorphin results in decreased expression of IL2 mRNA |
CTD |
PMID:23965172 |
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NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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G |
Il4 |
interleukin 4 |
increases expression |
ISO |
beta-Endorphin results in increased expression of IL4 mRNA |
CTD |
PMID:23965172 |
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NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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G |
Mapk1 |
mitogen activated protein kinase 1 |
increases phosphorylation |
ISO |
beta-Endorphin results in increased phosphorylation of MAPK1 protein |
CTD |
PMID:23965172 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
increases phosphorylation |
ISO |
beta-Endorphin results in increased phosphorylation of MAPK3 protein |
CTD |
PMID:23965172 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Nfkbia |
NFKB inhibitor alpha |
increases expression |
ISO |
beta-Endorphin results in increased expression of NFKBIA protein |
CTD |
PMID:22258905 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Pld2 |
phospholipase D2 |
increases activity |
ISO |
beta-Endorphin results in increased activity of PLD2 protein |
CTD |
PMID:23965172 |
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NCBI chr10:55,256,326...55,274,192
Ensembl chr10:55,256,359...55,272,808
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G |
Usp15 |
ubiquitin specific peptidase 15 |
increases expression |
ISO |
beta-Endorphin results in increased expression of USP15 mRNA |
CTD |
PMID:24068670 |
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NCBI chr 7:58,756,714...58,848,778
Ensembl chr 7:58,756,872...58,848,721
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G |
Crp |
C-reactive protein |
decreases expression |
ISO |
bivalirudin results in decreased expression of CRP protein |
CTD |
PMID:16118546 |
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NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
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G |
F2 |
coagulation factor II, thrombin |
multiple interactions decreases activity increases cleavage |
ISO |
bivalirudin binds to and results in decreased activity of F2 protein; bivalirudin inhibits the reaction [F2 protein results in increased expression of SELP protein] bivalirudin results in decreased activity of F2 protein F2 protein results in increased cleavage of bivalirudin |
CTD |
PMID:1290488 PMID:8456428 PMID:15080313 PMID:15155122 PMID:16084352 PMID:16845256 PMID:17696810 PMID:18449412 PMID:19124943 PMID:19644995 More...
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NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
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G |
F2r |
coagulation factor II (thrombin) receptor |
decreases activity |
ISO |
bivalirudin results in decreased activity of F2R protein |
CTD |
PMID:19124943 |
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NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870
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G |
F2rl3 |
F2R like thrombin or trypsin receptor 3 |
decreases activity |
ISO |
bivalirudin results in decreased activity of F2RL3 protein |
CTD |
PMID:19124943 |
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NCBI chr16:17,117,441...17,119,434
Ensembl chr16:17,117,441...17,119,472
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G |
Mpo |
myeloperoxidase |
decreases expression |
ISO |
bivalirudin results in decreased expression of MPO protein |
CTD |
PMID:18701766 |
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NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
P2ry12 |
purinergic receptor P2Y12 |
affects response to substance |
ISO |
P2RY12 affects the susceptibility to bivalirudin |
CTD |
PMID:14597584 |
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NCBI chr 2:143,481,468...143,523,340
Ensembl chr 2:143,481,430...143,523,361
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G |
Pdgfb |
platelet derived growth factor subunit B |
affects expression |
EXP |
bivalirudin affects the expression of PDGFB protein |
CTD |
PMID:10754393 PMID:11316950 |
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NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
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G |
Selp |
selectin P |
multiple interactions |
ISO |
bivalirudin inhibits the reaction [F2 protein results in increased expression of SELP protein] |
CTD |
PMID:16845256 |
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NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845
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G |
Hcrt |
hypocretin neuropeptide precursor |
decreases expression |
EXP |
salmon calcitonin results in decreased expression of HCRT mRNA |
CTD |
PMID:12686383 |
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NCBI chr10:85,689,979...85,691,214
Ensembl chr10:85,689,465...85,691,210
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G |
Pmch |
pro-melanin-concentrating hormone |
decreases expression |
EXP |
salmon calcitonin results in decreased expression of PMCH mRNA |
CTD |
PMID:12686383 |
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NCBI chr 7:22,511,934...22,513,250
Ensembl chr 7:22,511,934...22,513,250
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G |
Ada |
adenosine deaminase |
increases activity |
ISO |
Adrenocorticotropic Hormone results in increased activity of ADA protein |
CTD |
PMID:8868375 |
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NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088
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G |
Calca |
calcitonin-related polypeptide alpha |
increases abundance |
EXP |
CALCA protein results in increased abundance of Adrenocorticotropic Hormone |
CTD |
PMID:12639925 |
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NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
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G |
Cnp |
2',3'-cyclic nucleotide 3' phosphodiesterase |
decreases activity |
EXP |
Adrenocorticotropic Hormone results in decreased activity of CNP protein |
CTD |
PMID:3030154 |
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NCBI chr10:85,511,164...85,517,723
Ensembl chr10:85,511,160...85,517,720
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G |
Crh |
corticotropin releasing hormone |
multiple interactions increases secretion |
EXP |
Astemizole inhibits the reaction [Corticosterone inhibits the reaction [CRH protein results in increased secretion of Adrenocorticotropic Hormone]]; Corticosterone inhibits the reaction [CRH protein results in increased secretion of Adrenocorticotropic Hormone]; E 4031 inhibits the reaction [Corticosterone inhibits the reaction [CRH protein results in increased secretion of Adrenocorticotropic Hormone]]; Tetraethylammonium promotes the reaction [CRH protein results in increased secretion of Adrenocorticotropic Hormone] |
CTD |
PMID:18835572 |
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NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
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G |
Cyp17a1 |
cytochrome P450, family 17, subfamily a, polypeptide 1 |
affects abundance |
ISO |
CYP17A1 protein affects the abundance of Adrenocorticotropic Hormone |
CTD |
PMID:18645707 |
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NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
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G |
Gh1 |
growth hormone 1 |
multiple interactions |
ISO |
Adrenocorticotropic Hormone inhibits the reaction [INS protein results in increased secretion of GH1 protein] |
CTD |
PMID:3008584 |
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NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078
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G |
Htr2a |
5-hydroxytryptamine receptor 2A |
multiple interactions affects expression |
EXP |
Bupropion inhibits the reaction [Adrenocorticotropic Hormone affects the expression of HTR2A mRNA] |
CTD |
PMID:18239281 |
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NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
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G |
Ins2 |
insulin 2 |
multiple interactions |
ISO |
Adrenocorticotropic Hormone inhibits the reaction [INS protein results in increased secretion of GH1 protein] |
CTD |
PMID:3008584 |
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NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
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G |
Nr3c1 |
nuclear receptor subfamily 3, group C, member 1 |
affects abundance |
ISO |
NR3C1 gene polymorphism affects the abundance of Adrenocorticotropic Hormone |
CTD |
PMID:17716631 |
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NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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G |
Ppp1r1b |
protein phosphatase 1, regulatory (inhibitor) subunit 1B |
multiple interactions |
ISO |
Cocaine promotes the reaction [PPP1R1B protein results in increased abundance of Adrenocorticotropic Hormone] |
CTD |
PMID:10516482 |
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NCBI chr10:83,347,731...83,356,775
Ensembl chr10:83,347,731...83,356,775
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G |
Ucn2 |
urocortin 2 |
increases abundance |
ISO |
UCN2 protein results in increased abundance of Adrenocorticotropic Hormone |
CTD |
PMID:16330704 |
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NCBI chr 8:109,637,624...109,639,173
Ensembl chr 8:109,638,285...109,639,172
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G |
Crhr1 |
corticotropin releasing hormone receptor 1 |
increases expression decreases activity multiple interactions |
EXP |
Corticotropin-Releasing Hormone results in increased expression of CRHR1 mRNA Corticotropin-Releasing Hormone results in decreased activity of CRHR1 protein Pentobarbital inhibits the reaction [Corticotropin-Releasing Hormone results in decreased activity of CRHR1 protein]; Pentobarbital inhibits the reaction [Corticotropin-Releasing Hormone results in increased expression of CRHR1 mRNA] |
CTD |
PMID:12093084 |
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NCBI chr10:89,040,186...89,083,481
Ensembl chr10:89,040,203...89,083,481
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G |
Hsd11b2 |
hydroxysteroid 11-beta dehydrogenase 2 |
decreases expression |
ISO |
Cosyntropin results in decreased expression of HSD11B2 protein |
CTD |
PMID:11082157 |
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NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
affects activity |
ISO |
enfuvirtide affects the activity of CYP1A2 protein |
CTD |
PMID:15656696 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
affects activity |
ISO |
enfuvirtide affects the activity of CYP2C19 protein |
CTD |
PMID:15656696 |
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NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
affects activity |
ISO |
enfuvirtide affects the activity of CYP2E1 protein |
CTD |
PMID:15656696 |
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NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Lhb |
luteinizing hormone subunit beta |
decreases secretion decreases expression |
ISO |
ganirelix results in decreased secretion of LHB protein ganirelix results in decreased expression of LHB protein |
CTD |
PMID:17579202 PMID:21273126 |
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NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
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G |
Birc2 |
baculoviral IAP repeat-containing 2 |
multiple interactions |
ISO |
[gastrin 17 co-treated with CCKBR protein] results in decreased expression of BIRC2 |
CTD |
PMID:17704804 |
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NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
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G |
Birc3 |
baculoviral IAP repeat-containing 3 |
multiple interactions |
ISO |
[gastrin 17 co-treated with CCKBR protein] results in decreased expression of BIRC3 |
CTD |
PMID:17704804 |
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NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
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G |
Cckbr |
cholecystokinin B receptor |
multiple interactions |
ISO |
[gastrin 17 co-treated with CCKBR protein] results in decreased expression of BIRC2; [gastrin 17 co-treated with CCKBR protein] results in decreased expression of BIRC3; [gastrin 17 co-treated with CCKBR protein] results in increased expression of IER3 mRNA |
CTD |
PMID:17704804 |
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NCBI chr 1:159,771,733...159,781,738
Ensembl chr 1:159,771,733...159,814,881
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G |
Ier3 |
immediate early response 3 |
multiple interactions |
ISO |
[gastrin 17 co-treated with CCKBR protein] results in increased expression of IER3 mRNA |
CTD |
PMID:17704804 |
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NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
decreases activity |
ISO |
gastrin 17 results in decreased activity of NFKB1 protein |
CTD |
PMID:15623601 |
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NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
decreases activity |
ISO |
gastrin 17 results in decreased activity of RELA protein |
CTD |
PMID:15623601 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Sele |
selectin E |
decreases expression |
ISO |
gastrin 17 results in decreased expression of SELE protein |
CTD |
PMID:15623601 |
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NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
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G |
Cnr1 |
cannabinoid receptor 1 |
multiple interactions |
EXP |
Ghrelin inhibits the reaction [[Fructose co-treated with Streptozocin] results in decreased expression of CNR1 mRNA] |
CTD |
PMID:31468622 |
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NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
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G |
Glp1r |
glucagon-like peptide 1 receptor |
multiple interactions |
EXP |
Ghrelin inhibits the reaction [[Fructose co-treated with Streptozocin] results in decreased expression of GLP1R mRNA] |
CTD |
PMID:31468622 |
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NCBI chr20:8,972,004...9,010,241
Ensembl chr20:8,972,004...9,010,241
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
ghrelin inhibits the reaction [High fat diet increases expression of IL1b mRNA in heart] |
RGD |
PMID:32084395 |
RGD:242905211 |
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
ghrelin inhibits the reaction [High fat diet increases expression of Il6 mRNA in heart] |
RGD |
PMID:32084395 |
RGD:242905211 |
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Mir33 |
microRNA 33 |
multiple interactions |
EXP |
Ghrelin inhibits the reaction [[Fructose co-treated with Streptozocin] results in increased expression of MIR33A mRNA] |
CTD |
PMID:31468622 |
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NCBI chr 7:113,713,855...113,713,923
Ensembl chr 7:113,713,855...113,713,923
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
ISO |
ghrelin inhibits the reaction [High fat diet increases expression of Tgfb1 mRNA in heart] |
RGD |
PMID:32084395 |
RGD:242905211 |
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
ghrelin inhibits the reaction [high fat diet increases expression of TNF mRNA in heart] |
RGD |
PMID:32084395 |
RGD:242905211 |
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Itgam |
integrin subunit alpha M |
multiple interactions |
ISO |
High-density lipoprotein inhibits the reaction [cholesterol increases expression of ITGAM protein on monocytes and granulocytes] High-density lipoprotein inhibits the reaction [PMA increases expression of ITGAM protein on monocytes] |
RGD |
PMID:26026058 PMID:18617650 |
RGD:329853768, RGD:329901662 |
NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions increases activity |
ISO EXP |
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Insulin] results in decreased phosphorylation of AKT1 protein; [2-amino-3,4-dimethylimidazo(4,5-f)quinoline co-treated with Insulin] results in decreased phosphorylation of AKT1 protein; [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline co-treated with Insulin] results in decreased phosphorylation of AKT1 protein Insulin increases activity of Akt1 protein in adipocytes |
CTD RGD |
PMID:37005939 PMID:9065430 |
RGD:407420264 |
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Akt2 |
AKT serine/threonine kinase 2 |
multiple interactions |
ISO |
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Insulin] results in decreased phosphorylation of AKT2 protein; [2-amino-3,4-dimethylimidazo(4,5-f)quinoline co-treated with Insulin] results in decreased phosphorylation of AKT2 protein; [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline co-treated with Insulin] results in decreased phosphorylation of AKT2 protein |
CTD |
PMID:37005939 |
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NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
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G |
Akt3 |
AKT serine/threonine kinase 3 |
multiple interactions |
ISO |
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Insulin] results in decreased phosphorylation of AKT3 protein; [2-amino-3,4-dimethylimidazo(4,5-f)quinoline co-treated with Insulin] results in decreased phosphorylation of AKT3 protein; [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline co-treated with Insulin] results in decreased phosphorylation of AKT3 protein |
CTD |
PMID:37005939 |
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NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708
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G |
Casp1 |
caspase 1 |
multiple interactions |
EXP |
Insulin promotes the reaction [Ozone inhibits the reaction [Streptozocin results in increased expression of CASP1 mRNA]] |
CTD |
PMID:26614261 |
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NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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G |
Casp3 |
caspase 3 |
multiple interactions |
EXP |
Insulin promotes the reaction [Ozone inhibits the reaction [Streptozocin results in increased expression of CASP3 mRNA]] |
CTD |
PMID:26614261 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp9 |
caspase 9 |
multiple interactions |
EXP |
Insulin promotes the reaction [Ozone inhibits the reaction [Streptozocin results in increased expression of CASP9 mRNA]] |
CTD |
PMID:26614261 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cebpa |
CCAAT/enhancer binding protein alpha |
multiple interactions |
ISO |
[Dexamethasone co-treated with Insulin co-treated with Indomethacin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CEBPA mRNA; cordycepin inhibits the reaction [[Dexamethasone co-treated with Insulin co-treated with Indomethacin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CEBPA mRNA] |
CTD |
PMID:34575692 |
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NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
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G |
Fabp4 |
fatty acid binding protein 4 |
multiple interactions |
ISO |
[Dexamethasone co-treated with Insulin co-treated with Indomethacin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of FABP4 mRNA; cordycepin inhibits the reaction [[Dexamethasone co-treated with Insulin co-treated with Indomethacin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of FABP4 mRNA] |
CTD |
PMID:34575692 |
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NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions |
EXP |
Insulin promotes the reaction [Ozone inhibits the reaction [Streptozocin results in increased expression of HIF1A mRNA]] |
CTD |
PMID:26614261 |
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NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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G |
Insr |
insulin receptor |
decreases expression |
EXP |
insulin decreases expression of hepatic mRNA in streptozocin treated rats |
RGD |
PMID:1280238 |
RGD:15036814 |
NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
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G |
Kcnn4 |
potassium calcium-activated channel subfamily N member 4 |
increases expression multiple interactions |
EXP |
insulin increases expression of Kcnn4 mRNA and protein in vascular smooth muscle cells 2-(2-amino-3-methoxyphenyl)chromen-4-one inhibits the reaction [insulin increases expression of Kcnn4 mRNA and protein in vascular smooth muscle cells] |
RGD |
PMID:21463632 PMID:21463632 |
RGD:401794561, RGD:401794561 |
NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340
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G |
Lpl |
lipoprotein lipase |
multiple interactions |
ISO |
[Dexamethasone co-treated with Insulin co-treated with Indomethacin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of LPL mRNA; cordycepin inhibits the reaction [[Dexamethasone co-treated with Insulin co-treated with Indomethacin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of LPL mRNA] |
CTD |
PMID:34575692 |
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NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
EXP |
[[Paraquat results in increased phosphorylation of MAPK8 protein] which results in decreased abundance of Insulin] which results in increased abundance of Glucose |
CTD |
PMID:36394833 |
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NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mir210 |
microRNA 210 |
increases expression multiple interactions |
EXP |
Insulin increases expression of Mir210 miRNA in myocardial cell LY294002 inhibits the reaction [Insulin increases expression of Mir210 miRNA in myocardial cell] |
RGD |
PMID:25968948 PMID:25968948 |
RGD:11086706, RGD:11086706 |
NCBI chr 1:196,326,343...196,326,452
Ensembl chr 1:196,326,337...196,326,454
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions |
ISO |
[Dexamethasone co-treated with Insulin co-treated with Indomethacin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA; cordycepin inhibits the reaction [[Dexamethasone co-treated with Insulin co-treated with Indomethacin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA] |
CTD |
PMID:34575692 |
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NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Srebf1 |
sterol regulatory element binding transcription factor 1 |
increases expression multiple interactions |
EXP ISO |
insulin increases expression of Srebf1 mRNA in hepatoma cells cilostazol inhibits the reaction [insulin increases expression of Srebf1 mRNA in liver cancer cells] cilostazol inhibits the reaction [insulin increases expression of Srebf1 mRNA in primary hepatocytes] cilostazol inhibits the reaction [insulin increases expression of Srebf1 mRNA in hepatoma cells] |
RGD |
PMID:24458133 PMID:24458133 PMID:24458133 PMID:24458133 PMID:24458133 PMID:24458133 More...
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RGD:401842379, RGD:401842379, RGD:401842379, RGD:401842379, RGD:401842379, RGD:401842379 |
NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP |
Insulin promotes the reaction [Ozone inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]] |
CTD |
PMID:26614261 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tnf |
tumor necrosis factor |
increases secretion |
EXP |
Novorapid inhibits the reaction [Lipopolysaccharide increases secretion of Tnf protein in serum] |
RGD |
PMID:18078960 |
RGD:15023464 |
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
F2 |
coagulation factor II, thrombin |
multiple interactions |
ISO |
lepirudin binds to and results in decreased activity of F2 protein |
CTD |
PMID:15080313 PMID:18449412 |
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NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
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G |
Acaca |
acetyl-CoA carboxylase alpha |
multiple interactions |
ISO |
Liraglutide inhibits the reaction [IL1B protein results in increased phosphorylation of ACACA protein] |
CTD |
PMID:32898504 |
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NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
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G |
Adam33 |
ADAM metallopeptidase domain 33 |
decreases methylation increases expression |
ISO |
Liraglutide results in decreased methylation of ADAM33 promoter Liraglutide results in increased expression of ADAM33 mRNA; Liraglutide results in increased expression of ADAM33 protein |
CTD |
PMID:34534549 |
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NCBI chr 3:118,262,395...118,283,456
Ensembl chr 3:118,271,029...118,283,461
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G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
multiple interactions |
ISO |
Liraglutide inhibits the reaction [IL1B protein results in decreased secretion of ADIPOQ protein] |
CTD |
PMID:32898504 |
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NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
Liraglutide inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Liraglutide inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]] |
CTD |
PMID:31173752 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
ISO EXP |
Liraglutide inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; Wortmannin inhibits the reaction [Liraglutide inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]] Liraglutide inhibits the reaction [Methotrexate results in increased expression of BAX protein] |
CTD |
PMID:31173752 PMID:31362085 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO EXP |
Liraglutide inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]; Wortmannin inhibits the reaction [Liraglutide inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]] Liraglutide inhibits the reaction [Methotrexate results in decreased expression of BCL2 protein] |
CTD |
PMID:31173752 PMID:31362085 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Casp3 |
caspase 3 |
multiple interactions |
ISO EXP |
Liraglutide inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]; Wortmannin inhibits the reaction [Liraglutide inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]] Liraglutide inhibits the reaction [Methotrexate results in increased expression of and results in increased activity of CASP3 protein] |
CTD |
PMID:31173752 PMID:31362085 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Cdh1 |
cadherin 1 |
increases expression decreases methylation |
ISO |
Liraglutide results in increased expression of CDH1 mRNA; Liraglutide results in increased expression of CDH1 protein Liraglutide results in decreased methylation of CDH1 promoter |
CTD |
PMID:34534549 |
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NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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G |
Cpt1a |
carnitine palmitoyltransferase 1A |
multiple interactions |
ISO |
Liraglutide inhibits the reaction [IL1B protein results in decreased expression of CPT1A protein] |
CTD |
PMID:32898504 |
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NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
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G |
Creb1 |
cAMP responsive element binding protein 1 |
multiple interactions |
EXP |
Liraglutide inhibits the reaction [Methotrexate results in decreased phosphorylation of CREB1 protein] |
CTD |
PMID:31362085 |
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NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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G |
Cyba |
cytochrome b-245 alpha chain |
multiple interactions |
ISO |
Liraglutide inhibits the reaction [Pyruvaldehyde results in increased expression of CYBA mRNA] |
CTD |
PMID:35985417 |
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NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
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G |
Cybb |
cytochrome b-245 beta chain |
multiple interactions |
ISO |
Liraglutide inhibits the reaction [Pyruvaldehyde results in increased expression of CYBB mRNA] |
CTD |
PMID:35985417 |
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NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586
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G |
Dgat1 |
diacylglycerol O-acyltransferase 1 |
multiple interactions |
ISO |
Liraglutide inhibits the reaction [IL1B protein results in decreased expression of DGAT1 protein] |
CTD |
PMID:32898504 |
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NCBI chr 7:108,223,860...108,235,413
Ensembl chr 7:108,218,524...108,234,299
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G |
Esr1 |
estrogen receptor 1 |
increases expression |
ISO |
Liraglutide results in increased expression of ESR1 mRNA; Liraglutide results in increased expression of ESR1 protein |
CTD |
PMID:34534549 |
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NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Glp1r |
glucagon-like peptide 1 receptor |
multiple interactions increases activity increases expression |
EXP ISO |
Liraglutide inhibits the reaction [nitrofen results in decreased expression of GLP1R mRNA] Liraglutide results in increased activity of GLP1R protein Liraglutide binds to and results in increased activity of GLP1R protein Liraglutide results in increased expression of GLP1R mRNA |
CTD |
PMID:23354098 PMID:23471186 PMID:35985417 |
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NCBI chr20:8,972,004...9,010,241
Ensembl chr20:8,972,004...9,010,241
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
EXP |
Liraglutide inhibits the reaction [Methotrexate results in increased expression of GPT protein] |
CTD |
PMID:31362085 |
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NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
multiple interactions |
ISO |
Liraglutide inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of GSK3B protein]; Wortmannin inhibits the reaction [Liraglutide inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of GSK3B protein]] |
CTD |
PMID:31173752 |
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NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions |
EXP |
Liraglutide inhibits the reaction [Methotrexate results in increased expression of HMOX1 protein] |
CTD |
PMID:31362085 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
Liraglutide inhibits the reaction [IL1B protein results in decreased expression of CPT1A protein]; Liraglutide inhibits the reaction [IL1B protein results in decreased expression of DGAT1 protein]; Liraglutide inhibits the reaction [IL1B protein results in decreased expression of PPARGC1A protein]; Liraglutide inhibits the reaction [IL1B protein results in decreased secretion of ADIPOQ protein]; Liraglutide inhibits the reaction [IL1B protein results in increased expression of NOX4 mRNA]; Liraglutide inhibits the reaction [IL1B protein results in increased expression of NOX4 protein]; Liraglutide inhibits the reaction [IL1B protein results in increased phosphorylation of ACACA protein] |
CTD |
PMID:32898504 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
EXP |
Liraglutide inhibits the reaction [Methotrexate results in increased expression of IL6 protein] |
CTD |
PMID:31362085 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Mapt |
microtubule-associated protein tau |
multiple interactions |
ISO |
Liraglutide inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPT protein]; Wortmannin inhibits the reaction [Liraglutide inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPT protein]] |
CTD |
PMID:31173752 |
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NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
EXP |
Liraglutide inhibits the reaction [Methotrexate results in decreased expression of NFE2L2 protein] |
CTD |
PMID:31362085 |
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nox4 |
NADPH oxidase 4 |
multiple interactions |
ISO |
Liraglutide inhibits the reaction [IL1B protein results in increased expression of NOX4 mRNA]; Liraglutide inhibits the reaction [IL1B protein results in increased expression of NOX4 protein] |
CTD |
PMID:32898504 |
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NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
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G |
Ppargc1a |
PPARG coactivator 1 alpha |
multiple interactions |
ISO |
Liraglutide inhibits the reaction [IL1B protein results in decreased expression of PPARGC1A protein] |
CTD |
PMID:32898504 |
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NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
EXP |
Liraglutide inhibits the reaction [Methotrexate results in increased expression of PTGS2 protein] |
CTD |
PMID:31362085 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
EXP |
Liraglutide inhibits the reaction [Methotrexate results in increased expression of RELA protein] |
CTD |
PMID:31362085 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Sftpa1 |
surfactant protein A1 |
increases expression multiple interactions |
EXP |
Liraglutide results in increased expression of SFTPA1 mRNA Liraglutide inhibits the reaction [nitrofen results in decreased expression of SFTPA1 mRNA]; Liraglutide inhibits the reaction [nitrofen results in decreased expression of SFTPA1 protein] |
CTD |
PMID:23354098 |
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NCBI chr16:17,008,180...17,011,686
Ensembl chr16:17,008,180...17,011,685
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G |
Sftpb |
surfactant protein B |
increases expression |
EXP |
Liraglutide results in increased expression of SFTPB mRNA |
CTD |
PMID:23354098 |
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NCBI chr 4:104,359,303...104,368,439
Ensembl chr 4:104,359,396...104,368,436
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP |
Liraglutide inhibits the reaction [Methotrexate results in increased expression of TNF protein] |
CTD |
PMID:31362085 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tsc1 |
TSC complex subunit 1 |
multiple interactions |
EXP |
Liraglutide reverses the reaction [palmitate fatty acid decreases expression of tsc1 protein in hepatocytes] |
RGD |
PMID:31787541 |
RGD:25823196 |
NCBI chr 3:11,969,547...12,018,591
Ensembl chr 3:11,979,729...12,015,674
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G |
Xdh |
xanthine dehydrogenase |
multiple interactions |
ISO |
Liraglutide inhibits the reaction [Pyruvaldehyde results in increased expression of XDH mRNA] |
CTD |
PMID:35985417 |
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NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
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G |
Il18 |
interleukin 18 |
multiple interactions |
ISO |
lixisenatide inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 mRNA]; lixisenatide inhibits the reaction [Lipopolysaccharides results in increased secretion of IL18 protein] |
CTD |
PMID:38229325 |
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NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
lixisenatide inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; lixisenatide inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] |
CTD |
PMID:38229325 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Muc5ac |
mucin 5AC, oligomeric mucus/gel-forming |
multiple interactions |
ISO |
lixisenatide inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC mRNA]; lixisenatide inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC protein]; NFE2L2 protein affects the reaction [lixisenatide inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC mRNA]]; NFE2L2 protein affects the reaction [lixisenatide inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC protein]] |
CTD |
PMID:38229325 |
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NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
ISO |
NFE2L2 protein affects the reaction [lixisenatide inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC mRNA]]; NFE2L2 protein affects the reaction [lixisenatide inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC protein]] |
CTD |
PMID:38229325 |
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
lixisenatide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:38229325 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
lixisenatide inhibits the reaction [Lipopolysaccharides results in decreased expression of RELA mRNA]; lixisenatide inhibits the reaction [Lipopolysaccharides results in decreased expression of RELA protein]; lixisenatide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein] |
CTD |
PMID:38229325 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
lixisenatide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; lixisenatide inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] |
CTD |
PMID:38229325 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Itgam |
integrin subunit alpha M |
increases expression |
ISO |
Low-density lipoprotein increases expression of ITGAM protein on monocytes |
RGD |
PMID:22901456 |
RGD:329853769 |
NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
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G |
Abca1 |
ATP binding cassette subfamily A member 1 |
multiple interactions increases phosphorylation |
ISO |
mastoparan inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased export of Cholesterol]] mastoparan results in increased phosphorylation of ABCA1 protein |
CTD |
PMID:16118212 |
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NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
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G |
Apoa1 |
apolipoprotein A1 |
multiple interactions |
ISO |
mastoparan inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased export of Cholesterol]] |
CTD |
PMID:16118212 |
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NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
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G |
Calm1 |
calmodulin 1 |
affects binding |
EXP |
mastoparan binds to CALM1 protein |
CTD |
PMID:17098364 |
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NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
mastoparan inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] |
CTD |
PMID:21255617 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Nos1 |
nitric oxide synthase 1 |
decreases activity |
EXP |
mastoparan results in decreased activity of NOS1 protein |
CTD |
PMID:17098364 |
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NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
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G |
Actb |
actin, beta |
increases expression |
ISO |
Melitten results in increased expression of ACTB protein |
CTD |
PMID:34375656 |
|
NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877
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G |
Adam10 |
ADAM metallopeptidase domain 10 |
multiple interactions |
ISO |
Melitten results in increased cleavage of and results in increased activity of ADAM10 protein |
CTD |
PMID:22613720 |
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NCBI chr 8:71,346,008...71,477,889
Ensembl chr 8:71,345,837...71,477,889
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G |
Adam17 |
ADAM metallopeptidase domain 17 |
multiple interactions |
ISO |
Melitten results in increased cleavage of and results in increased activity of ADAM17 protein |
CTD |
PMID:22613720 |
|
NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639
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G |
Aim2 |
absent in melanoma 2 |
multiple interactions |
ISO |
AIM2 protein promotes the reaction [Melitten results in increased expression of IL18 protein]; AIM2 protein promotes the reaction [Melitten results in increased expression of IL1B protein] |
CTD |
PMID:22973906 |
|
NCBI chr13:85,865,206...85,906,996
Ensembl chr13:85,866,284...85,906,975
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
Melitten inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:22926441 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Alox5 |
arachidonate 5-lipoxygenase |
increases activity |
ISO |
Melitten results in increased activity of ALOX5 protein |
CTD |
PMID:18475477 |
|
NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
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G |
Apaf1 |
apoptotic peptidase activating factor 1 |
multiple interactions |
EXP ISO |
Melitten inhibits the reaction [[IL6 protein co-treated with IL6R protein] results in increased expression of APAF1 protein] Melitten affects the reaction [TGFB1 protein affects the localization of APAF1 protein] |
CTD |
PMID:21354845 PMID:21871910 |
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NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
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G |
Atp5po |
ATP synthase peripheral stalk subunit OSCP |
decreases expression |
ISO |
Melitten results in decreased expression of ATP5PO mRNA |
CTD |
PMID:37678661 |
|
NCBI chr11:31,165,218...31,171,530
Ensembl chr11:31,165,217...31,171,592
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G |
Bak1 |
BCL2-antagonist/killer 1 |
increases expression |
ISO |
Melitten results in increased expression of BAK1 protein |
CTD |
PMID:34375656 |
|
NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions increases expression |
ISO |
Melitten affects the reaction [TGFB1 protein affects the localization of BAX protein] Melitten results in increased expression of BAX protein Melitten analog results in increased expression of BAX mRNA; Melitten analog results in increased expression of BAX protein; Melitten results in increased expression of BAX protein |
CTD |
PMID:21871910 PMID:22027265 PMID:29387245 PMID:34375656 PMID:37678661 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression multiple interactions |
ISO EXP |
Melitten analog results in decreased expression of BCL2 mRNA; Melitten analog results in decreased expression of BCL2 protein; Melitten results in decreased expression of BCL2 protein Melitten inhibits the reaction [[IL6 protein co-treated with IL6R protein] results in increased expression of BCL2 mRNA]; Melitten inhibits the reaction [[IL6 protein co-treated with IL6R protein] results in increased expression of BCL2 protein] Melitten affects the reaction [TGFB1 protein affects the localization of BCL2 protein] |
CTD |
PMID:21354845 PMID:21456063 PMID:21871910 PMID:22027265 PMID:29387245 PMID:37678661 More...
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bdnf |
brain-derived neurotrophic factor |
decreases expression |
ISO |
Melitten results in decreased expression of BDNF protein |
CTD |
PMID:37678661 |
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NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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G |
Birc3 |
baculoviral IAP repeat-containing 3 |
decreases expression |
ISO |
Melitten results in decreased expression of BIRC3 protein |
CTD |
PMID:21456063 |
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NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
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G |
Calm1 |
calmodulin 1 |
affects binding |
EXP |
Melitten binds to CALM1 protein |
CTD |
PMID:17098364 |
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NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227
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G |
Casp3 |
caspase 3 |
increases expression increases cleavage decreases expression multiple interactions |
ISO EXP |
Melitten analog results in increased expression of CASP3 mRNA; Melitten analog results in increased expression of CASP3 protein; Melitten results in increased expression of CASP3 protein modified form Melitten results in increased cleavage of CASP3 protein Melitten results in decreased expression of CASP3 protein Melitten results in increased cleavage of and results in increased activity of CASP3 protein Melitten promotes the reaction [[IL6 protein co-treated with IL6R protein] results in increased expression of and results in increased activity of CASP3 protein]; Melitten promotes the reaction [[IL6 protein co-treated with IL6R protein] results in increased expression of CASP3 mRNA] Melitten inhibits the reaction [TGFB1 protein results in increased cleavage of CASP3 protein] |
CTD |
PMID:21354845 PMID:21456063 PMID:21871910 PMID:22027265 PMID:29387245 PMID:34375656 PMID:37678661 More...
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp8 |
caspase 8 |
increases expression |
ISO |
Melitten results in increased expression of CASP8 protein modified form |
CTD |
PMID:22027265 |
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
multiple interactions increases expression |
ISO EXP |
Melitten results in increased cleavage of and results in increased activity of CASP9 protein Melitten analog results in increased expression of CASP9 mRNA; Melitten analog results in increased expression of CASP9 protein Melitten promotes the reaction [[IL6 protein co-treated with IL6R protein] results in increased expression of CASP9 mRNA]; Melitten promotes the reaction [[IL6 protein co-treated with IL6R protein] results in increased expression of CASP9 protein] Melitten inhibits the reaction [TGFB1 protein results in increased cleavage of CASP9 protein] |
CTD |
PMID:21354845 PMID:21456063 PMID:21871910 PMID:29387245 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Ccnd1 |
cyclin D1 |
decreases expression |
ISO |
Melitten results in decreased expression of CCND1 protein |
CTD |
PMID:26189965 |
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Cdh1 |
cadherin 1 |
increases secretion |
ISO |
Melitten results in increased secretion of CDH1 protein |
CTD |
PMID:22613720 |
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NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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G |
Cdk4 |
cyclin-dependent kinase 4 |
decreases expression |
ISO |
Melitten results in decreased expression of CDK4 protein |
CTD |
PMID:26189965 |
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NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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G |
Chrna7 |
cholinergic receptor nicotinic alpha 7 subunit |
multiple interactions increases activity |
EXP |
Bungarotoxins inhibits the reaction [Melitten results in increased activity of CHRNA7 protein]; methyllycaconitine inhibits the reaction [Melitten results in increased activity of CHRNA7 protein] |
CTD |
PMID:19910175 |
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NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240
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G |
Chuk |
component of inhibitor of nuclear factor kappa B kinase complex |
multiple interactions affects binding |
ISO |
[Melitten inhibits the reaction [Nitroprusside results in increased phosphorylation of CHUK protein]] which results in decreased localization of NFKB1 protein; Melitten inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of CHUK protein]; Melitten inhibits the reaction [Nitroprusside results in increased phosphorylation of and results in increased activity of CHUK protein] Melitten binds to CHUK protein [Melitten inhibits the reaction [Nitroprusside results in increased phosphorylation of CHUK protein]] which results in decreased localization of NFKB1 protein; Dithiothreitol inhibits the reaction [Melitten binds to and results in decreased activity of CHUK protein]; Dithiothreitol inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased activity of CHUK protein]]; Glutathione inhibits the reaction [Melitten binds to and results in decreased activity of CHUK protein]; Glutathione inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased activity of CHUK protein]]; Hydrogen Peroxide inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased activity of CHUK protein]]; Melitten inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of CHUK protein]; Melitten inhibits the reaction [Nitroprusside results in increased activity of CHUK protein]; Melitten inhibits the reaction [Nitroprusside results in increased phosphorylation of and results in increased activity of CHUK protein]; Melitten inhibits the reaction [Nitroprusside results in increased phosphorylation of CHUK protein]; Melitten inhibits the reaction [Thioacetamide results in increased phosphorylation of CHUK protein]; Melitten inhibits the reaction [TNF protein results in increased activity of CHUK protein]; Melitten inhibits the reaction [TNF protein results in increased phosphorylation of CHUK protein] |
CTD |
PMID:17067557 PMID:21969711 |
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NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
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G |
Creb1 |
cAMP responsive element binding protein 1 |
decreases phosphorylation |
ISO |
Melitten results in decreased phosphorylation of CREB1 protein |
CTD |
PMID:37678661 |
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NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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G |
Cryab |
crystallin, alpha B |
multiple interactions |
EXP |
Melitten promotes the reaction [sodium arsenite results in increased expression of CRYAB mRNA]; Melitten promotes the reaction [sodium arsenite results in increased expression of CRYAB protein] |
CTD |
PMID:8591993 |
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NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157
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G |
Dlg4 |
discs large MAGUK scaffold protein 4 |
decreases expression |
ISO |
Melitten results in decreased expression of DLG4 protein |
CTD |
PMID:37678661 |
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NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153
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G |
Dnah12 |
dynein, axonemal, heavy chain 12 |
decreases expression |
ISO |
Melitten results in decreased expression of DNAH12 mRNA |
CTD |
PMID:37678661 |
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NCBI chr16:1,936,354...2,092,663
Ensembl chr16:1,937,817...2,092,664
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G |
Dnah17 |
dynein, axonemal, heavy chain 17 |
increases expression |
ISO |
Melitten results in increased expression of DNAH17 mRNA |
CTD |
PMID:37678661 |
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NCBI chr10:103,244,144...103,364,953
Ensembl chr10:103,249,363...103,364,901
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G |
Drd2 |
dopamine receptor D2 |
multiple interactions |
ISO |
Melitten inhibits the reaction [Spiperone binds to DRD2 protein] |
CTD |
PMID:20969853 |
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NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
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G |
Egfr |
epidermal growth factor receptor |
increases activity |
ISO |
Melitten results in increased activity of EGFR protein |
CTD |
PMID:22613720 |
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NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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G |
Fas |
Fas cell surface death receptor |
increases expression |
ISO |
Melitten results in increased expression of FAS mRNA; Melitten results in increased expression of FAS protein |
CTD |
PMID:16974113 PMID:17854560 |
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NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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G |
Fgf2 |
fibroblast growth factor 2 |
decreases expression |
ISO |
Melitten results in decreased expression of FGF2 mRNA |
CTD |
PMID:18076793 |
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NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
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G |
Fn1 |
fibronectin 1 |
multiple interactions |
ISO |
Melitten inhibits the reaction [Thioacetamide results in increased expression of FN1 protein] |
CTD |
PMID:21969711 |
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NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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G |
Gap43 |
growth associated protein 43 |
increases phosphorylation decreases expression |
ISO |
Melitten results in increased phosphorylation of GAP43 protein Melitten results in decreased expression of GAP43 protein |
CTD |
PMID:9852580 PMID:37678661 |
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NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045
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G |
Gli1 |
GLI family zinc finger 1 |
decreases expression |
ISO |
Melitten results in decreased expression of GLI1 protein |
CTD |
PMID:26189965 |
|
NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251
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G |
Gng11 |
G protein subunit gamma 11 |
decreases expression |
ISO |
Melitten results in decreased expression of GNG11 mRNA |
CTD |
PMID:37678661 |
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NCBI chr 4:32,023,003...32,028,443
Ensembl chr 4:32,023,003...32,028,442
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G |
Gnrh1 |
gonadotropin releasing hormone 1 |
multiple interactions |
ISO |
GNRH1 protein results in increased susceptibility to [Melitten binds to CGB3 protein] |
CTD |
PMID:19261682 |
|
NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581 Ensembl chr15:41,972,905...41,973,581
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G |
H19 |
H19 imprinted maternally expressed transcript |
decreases expression |
ISO |
Melitten results in decreased expression of H19 mRNA |
CTD |
PMID:34375656 |
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NCBI chr 1:197,730,698...197,733,374
Ensembl chr 1:197,730,698...197,733,134
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G |
Hrh2 |
histamine receptor H 2 |
increases response to substance increases activity multiple interactions |
EXP |
HRH2 protein results in increased susceptibility to Melitten Melitten results in increased activity of HRH2 protein Ranitidine inhibits the reaction [Melitten results in increased activity of HRH2 protein] |
CTD |
PMID:22995146 |
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NCBI chr17:10,366,004...10,407,791
Ensembl chr17:10,368,298...10,407,631
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G |
Htr1a |
5-hydroxytryptamine receptor 1A |
multiple interactions |
ISO |
Melitten inhibits the reaction [HTR1A protein inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]] |
CTD |
PMID:11356925 |
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NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442
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G |
Icam1 |
intercellular adhesion molecule 1 |
decreases expression |
ISO |
Melitten results in decreased expression of ICAM1 protein |
CTD |
PMID:12697458 |
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NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Ikbkb |
inhibitor of nuclear factor kappa B kinase subunit beta |
multiple interactions affects binding |
ISO |
Melitten inhibits the reaction [Nitroprusside results in increased activity of IKBKB protein] Melitten binds to IKBKB protein Dithiothreitol inhibits the reaction [Melitten binds to and results in decreased activity of IKBKB protein]; Dithiothreitol inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased activity of IKBKB protein]]; Glutathione inhibits the reaction [Melitten binds to and results in decreased activity of IKBKB protein]; Glutathione inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased activity of IKBKB protein]]; Hydrogen Peroxide inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased activity of IKBKB protein]]; Melitten inhibits the reaction [Lipopolysaccharides results in increased activity of IKBKB protein]; Melitten inhibits the reaction [Nitroprusside results in increased activity of IKBKB protein]; Melitten inhibits the reaction [TNF protein results in increased activity of IKBKB protein] |
CTD |
PMID:17067557 |
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NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
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G |
Il18 |
interleukin 18 |
increases expression multiple interactions |
ISO |
Melitten results in increased expression of IL18 protein AIM2 protein promotes the reaction [Melitten results in increased expression of IL18 protein] |
CTD |
PMID:22973906 |
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NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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G |
Il1b |
interleukin 1 beta |
multiple interactions increases expression |
ISO EXP |
AIM2 protein promotes the reaction [Melitten results in increased expression of IL1B protein] Melitten inhibits the reaction [TNF protein results in increased expression of IL1B protein] Melitten inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA] |
CTD |
PMID:17570326 PMID:21969711 PMID:22973906 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
EXP ISO |
Melitten inhibits the reaction [[IL6 protein co-treated with IL6R protein] results in increased expression of APAF1 protein]; Melitten inhibits the reaction [[IL6 protein co-treated with IL6R protein] results in increased expression of BCL2 mRNA]; Melitten inhibits the reaction [[IL6 protein co-treated with IL6R protein] results in increased expression of BCL2 protein]; Melitten inhibits the reaction [[IL6 protein co-treated with IL6R protein] results in increased expression of IL6STP1 mRNA]; Melitten inhibits the reaction [[IL6 protein co-treated with IL6R protein] results in increased expression of STAT3 mRNA]; Melitten inhibits the reaction [[IL6 protein co-treated with IL6R protein] results in increased localization of and results in increased activity of RELA protein]; Melitten inhibits the reaction [[IL6 protein co-treated with IL6R protein] results in increased phosphorylation of and results in increased activity of STAT3 protein]; Melitten inhibits the reaction [TNF protein results in increased expression of IL6 protein]; Melitten promotes the reaction [[IL6 protein co-treated with IL6R protein] results in increased expression of and results in increased activity of CASP3 protein]; Melitten promotes the reaction [[IL6 protein co-treated with IL6R protein] results in increased expression of CASP3 mRNA]; Melitten promotes the reaction [[IL6 protein co-treated with IL6R protein] results in increased expression of CASP9 mRNA]; Melitten promotes the reaction [[IL6 protein co-treated with IL6R protein] results in increased expression of CASP9 protein] Melitten inhibits the reaction [Acetic Acid results in increased expression of IL6 protein]; Melitten inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Melitten inhibits the reaction [Thioacetamide results in increased expression of IL6 protein] |
CTD |
PMID:17570326 PMID:21354845 PMID:21969711 PMID:33002459 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Il6r |
interleukin 6 receptor |
multiple interactions |
EXP |
Melitten inhibits the reaction [[IL6 protein co-treated with IL6R protein] results in increased expression of APAF1 protein]; Melitten inhibits the reaction [[IL6 protein co-treated with IL6R protein] results in increased expression of BCL2 mRNA]; Melitten inhibits the reaction [[IL6 protein co-treated with IL6R protein] results in increased expression of BCL2 protein]; Melitten inhibits the reaction [[IL6 protein co-treated with IL6R protein] results in increased expression of IL6STP1 mRNA]; Melitten inhibits the reaction [[IL6 protein co-treated with IL6R protein] results in increased expression of STAT3 mRNA]; Melitten inhibits the reaction [[IL6 protein co-treated with IL6R protein] results in increased localization of and results in increased activity of RELA protein]; Melitten inhibits the reaction [[IL6 protein co-treated with IL6R protein] results in increased phosphorylation of and results in increased activity of STAT3 protein]; Melitten promotes the reaction [[IL6 protein co-treated with IL6R protein] results in increased expression of and results in increased activity of CASP3 protein]; Melitten promotes the reaction [[IL6 protein co-treated with IL6R protein] results in increased expression of CASP3 mRNA]; Melitten promotes the reaction [[IL6 protein co-treated with IL6R protein] results in increased expression of CASP9 mRNA]; Melitten promotes the reaction [[IL6 protein co-treated with IL6R protein] results in increased expression of CASP9 protein] |
CTD |
PMID:21354845 |
|
NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
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G |
Jak2 |
Janus kinase 2 |
decreases phosphorylation |
ISO |
Melitten results in decreased phosphorylation of JAK2 protein |
CTD |
PMID:22027265 |
|
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions decreases expression |
ISO |
Melitten inhibits the reaction [Tetradecanoylphorbol Acetate results in increased localization of JUN protein] Melitten results in decreased expression of JUN mRNA |
CTD |
PMID:20082219 PMID:37678661 |
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NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Kdr |
kinase insert domain receptor |
decreases expression |
ISO |
Melitten results in decreased expression of KDR protein |
CTD |
PMID:23110475 |
|
NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
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G |
Lhcgr |
luteinizing hormone/choriogonadotropin receptor |
multiple interactions |
ISO |
LHCGR protein results in increased susceptibility to [Melitten binds to CGB3 protein] |
CTD |
PMID:19261682 |
|
NCBI chr 6:5,661,871...5,728,109
Ensembl chr 6:5,661,871...5,724,521
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G |
Map2 |
microtubule-associated protein 2 |
decreases expression |
ISO |
Melitten results in decreased expression of MAP2 protein |
CTD |
PMID:37678661 |
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NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809
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G |
Mapk1 |
mitogen activated protein kinase 1 |
decreases phosphorylation increases phosphorylation multiple interactions |
ISO EXP |
Melitten results in decreased phosphorylation of MAPK1 protein Melitten results in increased phosphorylation of MAPK1 protein Melitten inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of MAPK1 protein] Melitten inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Melitten inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]; Melitten results in increased phosphorylation of and results in increased activity of MAPK1 protein |
CTD |
PMID:17570326 PMID:17579088 PMID:17654254 PMID:20082219 PMID:22613720 PMID:22926441 PMID:23110475 More...
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions decreases phosphorylation increases phosphorylation |
ISO EXP |
Melitten inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Melitten inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]; Melitten results in increased phosphorylation of and results in increased activity of MAPK3 protein Melitten results in decreased phosphorylation of MAPK3 protein Melitten inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of MAPK3 protein] Melitten results in increased phosphorylation of MAPK3 protein |
CTD |
PMID:17570326 PMID:17579088 PMID:17654254 PMID:20082219 PMID:22613720 PMID:22926441 PMID:23110475 More...
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mecp2 |
methyl CpG binding protein 2 |
decreases expression |
ISO |
Melitten results in decreased expression of MECP2 mRNA; Melitten results in decreased expression of MECP2 protein |
CTD |
PMID:26189965 |
|
NCBI chr X:151,781,177...151,844,687
Ensembl chr X:151,789,930...151,844,689
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G |
Mmp2 |
matrix metallopeptidase 2 |
multiple interactions |
ISO |
Melitten inhibits the reaction [TNF protein results in increased secretion of MMP2 protein] |
CTD |
PMID:22926441 |
|
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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G |
Mmp3 |
matrix metallopeptidase 3 |
multiple interactions |
ISO |
Melitten inhibits the reaction [Lipopolysaccharides results in increased expression of MMP3 protein] |
CTD |
PMID:17303203 |
|
NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
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G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions |
ISO |
Melitten inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP9 protein]; Melitten inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased secretion of MMP9 protein]; Melitten inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]; Melitten inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; Melitten inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; Melitten inhibits the reaction [TNF protein results in increased secretion of MMP9 protein] |
CTD |
PMID:19969058 PMID:20082219 PMID:22926441 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Mt-atp6 |
mitochondrially encoded ATP synthase membrane subunit 6 |
increases expression |
ISO |
Melitten results in increased expression of ATP6 mRNA |
CTD |
PMID:37678661 |
|
NCBI chr MT:7,919...8,599 NCBI chr MT:7,919...8,599 NCBI chr MT:7,919...8,599 NCBI chr MT:7,919...8,599 NCBI chr MT:7,919...8,599 NCBI chr MT:7,919...8,599 NCBI chr MT:7,919...8,599
Ensembl chr MT:7,919...8,599
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G |
Mt-nd1 |
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 |
increases expression |
ISO |
Melitten results in increased expression of ND1 mRNA |
CTD |
PMID:37678661 |
|
NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694
Ensembl chr MT:2,740...3,694
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G |
Mt-nd2 |
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2 |
increases expression |
ISO |
Melitten results in increased expression of ND2 mRNA |
CTD |
PMID:37678661 |
|
NCBI chr MT:3,904...4,942 NCBI chr MT:3,904...4,942 NCBI chr MT:3,904...4,942 NCBI chr MT:3,904...4,942 NCBI chr MT:3,904...4,942 NCBI chr MT:3,904...4,942 NCBI chr MT:3,904...4,942 NCBI chr MT:3,904...4,942 NCBI chr MT:3,904...4,942
Ensembl chr MT:3,904...4,942
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G |
Mt-nd4 |
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 |
increases expression |
ISO |
Melitten results in increased expression of ND4 mRNA |
CTD |
PMID:37678661 |
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NCBI chr MT:10,160...11,537 NCBI chr MT:10,160...11,537 NCBI chr MT:10,160...11,537 NCBI chr MT:10,160...11,537 NCBI chr MT:10,160...11,537 NCBI chr MT:10,160...11,537 NCBI chr MT:10,160...11,537 NCBI chr MT:10,160...11,537
Ensembl chr MT:10,160...11,537
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Mt-nd4l |
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4L |
increases expression |
ISO |
Melitten results in increased expression of ND4L mRNA |
CTD |
PMID:37678661 |
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NCBI chr MT:9,870...10,166 NCBI chr MT:9,870...10,166 NCBI chr MT:9,870...10,166 NCBI chr MT:9,870...10,166 NCBI chr MT:9,870...10,166 NCBI chr MT:9,870...10,166 NCBI chr MT:9,870...10,166 NCBI chr MT:9,870...10,166 NCBI chr MT:9,870...10,166
Ensembl chr MT:9,870...10,166
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Mt-nd5 |
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 |
increases expression |
ISO |
Melitten results in increased expression of ND5 mRNA |
CTD |
PMID:37678661 |
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NCBI chr MT:11,736...13,565 NCBI chr MT:11,736...13,565 NCBI chr MT:11,736...13,565 NCBI chr MT:11,736...13,565 NCBI chr MT:11,736...13,565 NCBI chr MT:11,736...13,565 NCBI chr MT:11,736...13,565 NCBI chr MT:11,736...13,565 NCBI chr MT:11,736...13,565
Ensembl chr MT:11,736...13,565
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Ndufa2 |
NADH:ubiquinone oxidoreductase subunit A2 |
decreases expression |
ISO |
Melitten results in decreased expression of NDUFA2 mRNA |
CTD |
PMID:37678661 |
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NCBI chr18:28,355,774...28,357,863
Ensembl chr18:28,355,774...28,358,076
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Ndufb10 |
NADH:ubiquinone oxidoreductase subunit B10 |
decreases expression |
ISO |
Melitten results in decreased expression of NDUFB10 mRNA |
CTD |
PMID:37678661 |
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NCBI chr10:13,749,273...13,751,434
Ensembl chr10:13,749,275...13,751,442
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Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions decreases localization |
ISO |
[Melitten inhibits the reaction [Nitroprusside results in increased phosphorylation of CHUK protein]] which results in decreased localization of NFKB1 protein; [Melitten inhibits the reaction [Nitroprusside results in increased phosphorylation of NFKBIA protein]] which results in decreased localization of NFKB1 protein; Melitten inhibits the reaction [Lipopolysaccharides results in increased localization of and results in increased activity of NFKB1 protein]; Melitten inhibits the reaction [Lipopolysaccharides results in increased localization of NFKB1 protein]; Melitten inhibits the reaction [Nitroprusside results in increased localization of NFKB1 protein]; pyrazolanthrone inhibits the reaction [Melitten inhibits the reaction [Lipopolysaccharides results in increased localization of NFKB1 protein]]; pyrazolanthrone inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased localization of NFKB1 protein]] Melitten results in decreased localization of NFKB1 protein |
CTD |
PMID:15529353 PMID:17067557 PMID:18507870 PMID:21456063 |
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NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
[Melitten inhibits the reaction [Nitroprusside results in increased phosphorylation of NFKBIA protein]] which results in decreased localization of NFKB1 protein; Melitten inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]; Melitten inhibits the reaction [Nitroprusside results in increased phosphorylation of NFKBIA protein]; Melitten inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Melitten inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; pyrazolanthrone inhibits the reaction [Melitten inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; pyrazolanthrone inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased phosphorylation of NFKBIA protein]] [Melitten inhibits the reaction [Nitroprusside results in increased phosphorylation of NFKBIA protein]] which results in decreased localization of NFKB1 protein; Dithiothreitol inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased phosphorylation of NFKBIA protein]]; Glutathione inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased phosphorylation of NFKBIA protein]]; Melitten inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]; Melitten inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]; Melitten inhibits the reaction [Nitroprusside results in increased phosphorylation of NFKBIA protein]; Melitten inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:15529353 PMID:17067557 PMID:17570326 PMID:18507870 PMID:22926441 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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Nos1 |
nitric oxide synthase 1 |
decreases activity |
EXP |
Melitten results in decreased activity of NOS1 protein |
CTD |
PMID:17098364 |
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NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
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Nos2 |
nitric oxide synthase 2 |
decreases expression multiple interactions |
ISO |
Melitten results in decreased expression of NOS2 protein Melitten inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Melitten inhibits the reaction [[Nitroprusside results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Melitten inhibits the reaction [[TNF protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Melitten inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] |
CTD |
PMID:15529353 PMID:17067557 PMID:17570326 PMID:21456063 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Ntrk2 |
neurotrophic receptor tyrosine kinase 2 |
decreases phosphorylation |
ISO |
Melitten results in decreased phosphorylation of NTRK2 protein |
CTD |
PMID:37678661 |
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NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
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P2rx7 |
purinergic receptor P2X 7 |
increases activity increases response to substance |
ISO |
Melitten results in increased activity of P2RX7 protein P2RX7 protein results in increased susceptibility to Melitten |
CTD |
PMID:22613720 |
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NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619
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Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO |
Melitten inhibits the reaction [TGFB1 protein results in increased cleavage of PARP1 protein] |
CTD |
PMID:21871910 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Pdgfrb |
platelet derived growth factor receptor beta |
multiple interactions |
EXP |
Melitten results in decreased phosphorylation of and results in decreased activity of PDGFRB protein |
CTD |
PMID:17654254 |
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NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843
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Pla2g2a |
phospholipase A2 group IIA |
multiple interactions |
ISO |
Melitten inhibits the reaction [Acetic Acid results in increased expression of PLA2G2A protein] |
CTD |
PMID:33002459 |
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NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014
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Pla2g4a |
phospholipase A2 group 4A |
decreases expression |
ISO |
Melitten results in decreased expression of PLA2G4A protein |
CTD |
PMID:21456063 |
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NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266
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Plcg1 |
phospholipase C, gamma 1 |
decreases phosphorylation |
EXP |
Melitten results in decreased phosphorylation of PLCG1 protein |
CTD |
PMID:17654254 |
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NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330
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Ptch1 |
patched 1 |
increases expression |
ISO |
Melitten results in increased expression of PTCH1 protein |
CTD |
PMID:26189965 |
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NCBI chr17:1,542,705...1,607,730
Ensembl chr17:1,542,877...1,607,333
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Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions increases expression decreases expression |
ISO |
[Melitten results in decreased expression of PTGS2 protein] which results in decreased chemical synthesis of Dinoprostone; Melitten inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Melitten inhibits the reaction [[Nitroprusside results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; SB 203580 inhibits the reaction [Melitten results in decreased expression of PTGS2 protein] Melitten results in increased expression of PTGS2 mRNA; Melitten results in increased expression of PTGS2 protein [Melitten results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; Melitten inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Melitten inhibits the reaction [[Nitroprusside results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Melitten inhibits the reaction [[TNF protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Melitten inhibits the reaction [Acetic Acid results in increased expression of PTGS2 protein]; Melitten inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA] |
CTD |
PMID:11094054 PMID:11821123 PMID:15529353 PMID:17067557 PMID:17570326 PMID:17579088 PMID:21456063 PMID:23110475 PMID:33002459 More...
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Rab11a |
RAB11a, member RAS oncogene family |
multiple interactions |
ISO |
Melitten results in decreased localization of [RAB11A protein co-treated with RAB5A protein] |
CTD |
PMID:22683840 |
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NCBI chr 8:65,223,698...65,246,461
Ensembl chr 8:65,222,949...65,246,525
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Rab5a |
RAB5A, member RAS oncogene family |
multiple interactions |
ISO |
Melitten results in decreased localization of [RAB11A protein co-treated with RAB5A protein]; Melitten results in increased localization of [SLC6A3 protein co-treated with RAB5A protein] |
CTD |
PMID:22683840 |
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NCBI chr 9:6,483,906...6,512,877
Ensembl chr 9:6,484,469...6,512,873
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Rac1 |
Rac family small GTPase 1 |
decreases activity |
ISO |
Melitten results in decreased activity of RAC1 protein |
CTD |
PMID:18506888 |
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NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
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Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions decreases localization |
ISO EXP |
Melitten inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]; Melitten inhibits the reaction [Nitroprusside results in increased localization of RELA protein]; Melitten inhibits the reaction [Tetradecanoylphorbol Acetate results in increased localization of RELA protein]; Melitten inhibits the reaction [TNF protein affects the localization of RELA protein]; pyrazolanthrone inhibits the reaction [Melitten inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]]; pyrazolanthrone inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased localization of RELA protein]] Melitten inhibits the reaction [[IL6 protein co-treated with IL6R protein] results in increased localization of and results in increased activity of RELA protein] Melitten inhibits the reaction [Lipopolysaccharides results in increased localization of and results in increased activity of RELA protein]; Melitten inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]; Melitten inhibits the reaction [Nitroprusside results in increased localization of RELA protein]; pyrazolanthrone inhibits the reaction [Melitten inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]]; pyrazolanthrone inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased localization of RELA protein]] Melitten results in decreased localization of RELA protein |
CTD |
PMID:17570326 PMID:18507870 PMID:20082219 PMID:21354845 PMID:21456063 PMID:22926441 More...
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Scn10a |
sodium voltage-gated channel alpha subunit 10 |
increases expression multiple interactions |
EXP |
Melitten results in increased expression of SCN10A mRNA; Melitten results in increased expression of SCN10A protein [Melitten results in increased expression of SCN10A protein] which results in increased transport of Sodium |
CTD |
PMID:23264124 |
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NCBI chr 8:119,350,723...119,462,882
Ensembl chr 8:119,350,724...119,462,614
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Scn11a |
sodium voltage-gated channel alpha subunit 11 |
increases expression multiple interactions increases response to substance |
EXP |
Melitten results in increased expression of SCN11A mRNA; Melitten results in increased expression of SCN11A protein [Melitten results in increased expression of SCN11A protein] which results in increased transport of Sodium SCN11A protein results in increased susceptibility to Melitten |
CTD |
PMID:23264124 |
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NCBI chr 8:119,495,550...119,567,044
Ensembl chr 8:119,496,769...119,567,044
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Sdhc |
succinate dehydrogenase complex subunit C |
decreases expression |
ISO |
Melitten results in decreased expression of SDHC mRNA |
CTD |
PMID:37678661 |
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NCBI chr13:83,544,652...83,565,560
Ensembl chr13:83,544,652...83,566,253
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Shh |
sonic hedgehog signaling molecule |
decreases expression |
ISO |
Melitten results in decreased expression of SHH protein |
CTD |
PMID:26189965 |
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NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170
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Slc6a3 |
solute carrier family 6 member 3 |
increases localization multiple interactions |
ISO |
Melitten results in increased localization of SLC6A3 protein Cocaine inhibits the reaction [Melitten results in increased localization of SLC6A3 protein]; Melitten inhibits the reaction [2beta-carbomethoxy-3beta-(4-iodophenyl)tropane binds to SLC6A3 protein]; Melitten inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]; Melitten results in increased localization of [SLC6A3 protein co-treated with RAB5A protein] |
CTD |
PMID:20969853 PMID:22683840 |
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NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
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Socs3 |
suppressor of cytokine signaling 3 |
decreases expression |
ISO |
Melitten results in decreased expression of SOCS3 mRNA |
CTD |
PMID:37678661 |
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NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
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Stat3 |
signal transducer and activator of transcription 3 |
decreases phosphorylation multiple interactions |
ISO EXP |
Melitten results in decreased phosphorylation of STAT3 protein Melitten inhibits the reaction [[IL6 protein co-treated with IL6R protein] results in increased expression of STAT3 mRNA]; Melitten inhibits the reaction [[IL6 protein co-treated with IL6R protein] results in increased phosphorylation of and results in increased activity of STAT3 protein] TNFRSF10A protein affects the reaction [Melitten results in decreased phosphorylation of STAT3 protein]; TNFRSF21 protein affects the reaction [Melitten results in decreased phosphorylation of STAT3 protein]; TNFRSF25 protein affects the reaction [Melitten results in decreased phosphorylation of STAT3 protein] |
CTD |
PMID:21354845 PMID:22027265 |
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NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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Syp |
synaptophysin |
decreases expression |
ISO |
Melitten results in decreased expression of SYP protein |
CTD |
PMID:37678661 |
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NCBI chr X:14,849,444...14,864,553
Ensembl chr X:14,849,444...14,864,745
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Tbxa2r |
thromboxane A2 receptor |
increases response to substance |
EXP |
TBXA2R protein results in increased susceptibility to Melitten |
CTD |
PMID:16524625 |
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NCBI chr 7:8,383,347...8,390,753
Ensembl chr 7:8,383,378...8,388,176
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Tgfa |
transforming growth factor alpha |
increases secretion |
ISO |
Melitten results in increased secretion of TGFA protein |
CTD |
PMID:22613720 |
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NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894
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Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions decreases activity |
ISO |
Melitten affects the reaction [TGFB1 protein affects the localization of APAF1 protein]; Melitten affects the reaction [TGFB1 protein affects the localization of BAX protein]; Melitten affects the reaction [TGFB1 protein affects the localization of BCL2 protein]; Melitten inhibits the reaction [TGFB1 protein results in increased cleavage of CASP3 protein]; Melitten inhibits the reaction [TGFB1 protein results in increased cleavage of CASP9 protein]; Melitten inhibits the reaction [TGFB1 protein results in increased cleavage of PARP1 protein]; Melitten inhibits the reaction [Thioacetamide results in increased expression of TGFB1 protein] Melitten results in decreased activity of TGFB1 protein |
CTD |
PMID:21871910 PMID:21969711 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Tlr4 |
toll-like receptor 4 |
multiple interactions |
ISO |
Melitten inhibits the reaction [Acetic Acid results in increased expression of TLR4 protein] |
CTD |
PMID:33002459 |
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NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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Tnf |
tumor necrosis factor |
multiple interactions decreases secretion increases expression |
ISO EXP |
Melitten inhibits the reaction [TNF protein affects the localization of RELA protein]; Melitten inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Melitten inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; Melitten inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; Melitten inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]; Melitten inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]; Melitten inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]; Melitten inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; Melitten inhibits the reaction [TNF protein results in increased secretion of MMP2 protein]; Melitten inhibits the reaction [TNF protein results in increased secretion of MMP9 protein] Melitten results in decreased secretion of TNF protein Melitten inhibits the reaction [TNF protein results in increased expression of IL1B protein]; Melitten inhibits the reaction [TNF protein results in increased expression of IL6 protein] Melitten results in increased expression of TNF mRNA Melitten inhibits the reaction [[TNF protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Melitten inhibits the reaction [[TNF protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Melitten inhibits the reaction [Acetic Acid results in increased expression of TNF protein]; Melitten inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Melitten inhibits the reaction [Thioacetamide results in increased expression of TNF protein]; Melitten inhibits the reaction [TNF protein results in increased activity of CHUK protein]; Melitten inhibits the reaction [TNF protein results in increased activity of IKBKB protein]; Melitten inhibits the reaction [TNF protein results in increased phosphorylation of CHUK protein]; Melitten inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:11094054 PMID:11821123 PMID:17067557 PMID:17570326 PMID:21969711 PMID:22926441 PMID:33002459 More...
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnfrsf10b |
TNF receptor superfamily member 10b |
multiple interactions increases expression affects response to substance |
ISO |
TNFRSF10A protein affects the reaction [Melitten results in decreased phosphorylation of STAT3 protein] Melitten results in increased expression of TNFRSF10A mRNA TNFRSF10A protein affects the susceptibility to Melitten |
CTD |
PMID:22027265 |
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NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467
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G |
Tnfrsf21 |
TNF receptor superfamily member 21 |
increases expression affects response to substance multiple interactions |
ISO |
Melitten results in increased expression of TNFRSF21 mRNA TNFRSF21 protein affects the susceptibility to Melitten TNFRSF21 protein affects the reaction [Melitten results in decreased phosphorylation of STAT3 protein] |
CTD |
PMID:22027265 |
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NCBI chr 9:17,879,156...17,954,085
Ensembl chr 9:17,879,156...17,954,085
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G |
Tnfrsf25 |
TNF receptor superfamily member 25 |
increases expression multiple interactions affects response to substance |
ISO |
Melitten results in increased expression of TNFRSF25 mRNA TNFRSF25 protein affects the reaction [Melitten results in decreased phosphorylation of STAT3 protein] TNFRSF25 protein affects the susceptibility to Melitten |
CTD |
PMID:22027265 |
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NCBI chr 5:162,621,669...162,626,341
Ensembl chr 5:162,622,075...162,626,341
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G |
Traf6 |
TNF receptor associated factor 6 |
multiple interactions |
ISO |
Melitten inhibits the reaction [Acetic Acid results in increased expression of TRAF6 protein] |
CTD |
PMID:33002459 |
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NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507
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G |
Trpv1 |
transient receptor potential cation channel, subfamily V, member 1 |
multiple interactions increases response to substance increases activity |
EXP |
[Melitten results in increased activity of TRPV1 protein] which results in increased transport of Calcium; capsazepine inhibits the reaction [[Melitten results in increased activity of TRPV1 protein] which results in increased transport of Calcium]; capsazepine inhibits the reaction [TRPV1 protein results in increased susceptibility to Melitten]; Indomethacin inhibits the reaction [[Melitten results in increased activity of TRPV1 protein] which results in increased transport of Calcium]; Masoprocol inhibits the reaction [[Melitten results in increased activity of TRPV1 protein] which results in increased transport of Calcium]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Melitten results in increased activity of TRPV1 protein] which results in increased transport of Calcium] |
CTD |
PMID:16446039 PMID:21453681 |
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NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
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G |
Uqcrfs1 |
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 |
decreases expression |
ISO |
Melitten results in decreased expression of UQCRFS1 mRNA |
CTD |
PMID:37678661 |
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NCBI chr17:33,977,908...33,982,478
Ensembl chr17:33,977,921...33,982,479
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G |
Vcam1 |
vascular cell adhesion molecule 1 |
multiple interactions |
ISO |
Melitten inhibits the reaction [Thioacetamide results in increased expression of VCAM1 protein] |
CTD |
PMID:21969711 |
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NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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G |
Vdac1 |
voltage-dependent anion channel 1 |
increases expression |
ISO |
Melitten results in increased expression of VDAC1 protein |
CTD |
PMID:34375656 |
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NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640
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G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions decreases expression |
ISO |
SB 203580 inhibits the reaction [Melitten results in decreased expression of VEGFA protein] Melitten results in decreased expression of VEGFA mRNA; Melitten results in decreased expression of VEGFA protein |
CTD |
PMID:18076793 PMID:23110475 |
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Xiap |
X-linked inhibitor of apoptosis |
decreases expression |
ISO |
Melitten results in decreased expression of XIAP protein |
CTD |
PMID:21456063 |
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NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700
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G |
Xist |
X inactive specific transcript |
increases expression |
ISO |
Melitten results in increased expression of XIST mRNA |
CTD |
PMID:34375656 |
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NCBI chr X:68,474,987...68,492,500
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G |
Tacr2 |
tachykinin receptor 2 |
affects binding |
ISO |
Neurokinin A binds to TACR2 protein |
CTD |
PMID:15925360 |
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NCBI chr20:30,208,907...30,223,446
Ensembl chr20:30,208,907...30,223,446
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G |
Snai1 |
snail family transcriptional repressor 1 |
decreases expression |
ISO |
Nisin results in decreased expression of SNAI1 mRNA |
CTD |
PMID:36084725 |
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NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
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G |
Twist1 |
twist family bHLH transcription factor 1 |
decreases expression |
ISO |
Nisin results in decreased expression of TWIST1 mRNA |
CTD |
PMID:36084725 |
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NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653
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G |
Oprl1 |
opioid related nociceptin receptor 1 |
multiple interactions affects binding |
ISO |
Endocannabinoids inhibits the reaction [Nociceptin binds to and results in increased activity of OPRL1 protein]; Nociceptin binds to and results in increased activity of OPRL1 protein Nociceptin binds to OPRL1 protein |
CTD |
PMID:20359694 PMID:21866885 PMID:30102254 |
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NCBI chr 3:168,831,934...168,839,920
Ensembl chr 3:168,834,003...168,839,920
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G |
Clu |
clusterin |
multiple interactions |
EXP |
omega-Conotoxin GVIA inhibits the reaction [methoxyacetic acid results in increased expression of and results in increased secretion of CLU protein] |
CTD |
PMID:14656996 |
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NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
EXP |
[Nifedipine co-treated with omega-Conotoxin GVIA co-treated with omega-Agatoxin IVA] inhibits the reaction [Potassium Chloride affects the expression of FOS mRNA] |
CTD |
PMID:20211981 |
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Kcna1 |
potassium voltage-gated channel subfamily A member 1 |
multiple interactions |
EXP |
[Nifedipine co-treated with omega-Conotoxin GVIA co-treated with omega-Agatoxin IVA] promotes the reaction [Potassium Chloride results in increased expression of KCNA1 mRNA] |
CTD |
PMID:20211981 |
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NCBI chr 4:159,464,223...159,472,905
Ensembl chr 4:159,464,188...159,472,682
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G |
Kcnc3 |
potassium voltage-gated channel subfamily C member 3 |
multiple interactions |
EXP |
[Nifedipine co-treated with omega-Conotoxin GVIA co-treated with omega-Agatoxin IVA] inhibits the reaction [Potassium Chloride results in increased expression of KCNC3 mRNA] |
CTD |
PMID:20211981 |
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NCBI chr 1:95,080,960...95,095,165
Ensembl chr 1:95,080,960...95,095,160
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G |
Sct |
secretin |
multiple interactions |
EXP |
omega-Conotoxin GVIA inhibits the reaction [Potassium Chloride results in increased secretion of SCT protein] |
CTD |
PMID:16888165 |
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NCBI chr 1:196,382,857...196,383,668
Ensembl chr 1:196,382,856...196,383,658
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G |
Snca |
synuclein alpha |
multiple interactions |
EXP |
omega-Conotoxin GVIA inhibits the reaction [SNCA protein results in increased uptake of Calcium] |
CTD |
PMID:17179863 |
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NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
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G |
Tac1 |
tachykinin, precursor 1 |
multiple interactions |
EXP |
omega-Conotoxin GVIA inhibits the reaction [Potassium results in increased secretion of TAC1 protein modified form] |
CTD |
PMID:2325850 |
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NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
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G |
Map3k7 |
mitogen activated protein kinase kinase kinase 7 |
multiple interactions increases phosphorylation |
ISO |
Albiflorin inhibits the reaction [oxidized LDL increases phosphorylation of MAP3K7 protein in umbilical vein endothelial cells] Oxidized LDL increases phosphorylation of MAP3K7 protein in umbilical vein endothelial cells |
RGD |
PMID:35601145 PMID:35601145 |
RGD:155804296, RGD:155804296 |
NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597
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G |
Nr1h3 |
nuclear receptor subfamily 1, group H, member 3 |
decreases expression increases expression |
ISO |
Oxidized LDL decreases expression of Nr1h3 mRNA and protein in vascular smooth muscle cells Oxidized LDL increases expression of NR1H3 protein in macrophages |
RGD |
PMID:27807703 PMID:32780606 |
RGD:401850553, RGD:401850600 |
NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722
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G |
Phactr1 |
phosphatase and actin regulator 1 |
increases expression decreases expression |
ISO |
Oxidized low-density lipoprotein increases expression of PHACTR1 mRNA in umbilical vein endothelial cells Oxidized low density lipoprotein increases expression of short length PHACTR1 mRNA in macrophages Oxidized low density lipoprotein decreases expression of intermediate length PHACTR1 mRNA in macrophages |
RGD |
PMID:36091033 PMID:27187934 PMID:27187934 |
RGD:401900131, RGD:401900169, RGD:401900169 |
NCBI chr17:21,560,364...22,040,166
Ensembl chr17:21,562,721...22,039,831
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G |
Ptgis |
prostaglandin I2 synthase |
decreases expression |
ISO |
Oxidized LDL decreases expression of PTGIS mRNA in aortic endothelial cells and aortic smooth muscle cells |
RGD |
PMID:22112851 |
RGD:401959395 |
NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451
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G |
Ptpn1 |
protein tyrosine phosphatase, non-receptor type 1 |
increases expression |
ISO |
Oxidized-LDL increases expression of PTPN1 mRNA and protein in endothelial cell of umbilical vein |
RGD |
PMID:35747159 |
RGD:401976383 |
NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504
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G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
ISO |
PR 39 inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] |
CTD |
PMID:12388057 |
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NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Sele |
selectin E |
multiple interactions |
ISO |
PR 39 inhibits the reaction [TNF protein results in increased expression of SELE protein] |
CTD |
PMID:12388057 |
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NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
PR 39 inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; PR 39 inhibits the reaction [TNF protein results in increased expression of SELE protein]; PR 39 inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] |
CTD |
PMID:12388057 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Vcam1 |
vascular cell adhesion molecule 1 |
multiple interactions |
ISO |
PR 39 inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] |
CTD |
PMID:12388057 |
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NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
EXP |
royal jelly inhibits the reaction [Fluorides results in decreased expression of BAX protein] |
CTD |
PMID:34227456 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO EXP |
royal jelly inhibits the reaction [Nicotine results in decreased expression of BCL2 mRNA] royal jelly inhibits the reaction [Fluorides results in increased expression of BCL2 protein] |
CTD |
PMID:30896085 PMID:34227456 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bdnf |
brain-derived neurotrophic factor |
multiple interactions |
EXP |
royal jelly inhibits the reaction [Fluorides results in decreased expression of BDNF protein] |
CTD |
PMID:34227456 |
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NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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G |
Casp3 |
caspase 3 |
multiple interactions |
ISO EXP |
royal jelly inhibits the reaction [Nicotine results in increased expression of CASP3 mRNA] royal jelly inhibits the reaction [Fluorides results in decreased expression of CASP3 protein] |
CTD |
PMID:30896085 PMID:34227456 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp6 |
caspase 6 |
multiple interactions |
EXP |
royal jelly inhibits the reaction [Fluorides results in decreased expression of CASP6 protein] |
CTD |
PMID:34227456 |
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NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
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G |
Casp9 |
caspase 9 |
multiple interactions |
EXP |
royal jelly inhibits the reaction [Fluorides results in decreased expression of CASP9 protein] |
CTD |
PMID:34227456 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
multiple interactions |
EXP ISO |
royal jelly inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; royal jelly inhibits the reaction [Fluorides results in decreased activity of CAT protein] royal jelly inhibits the reaction [Nicotine results in decreased activity of CAT protein] |
CTD |
PMID:20369241 PMID:30896085 PMID:34227456 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Ccnd1 |
cyclin D1 |
multiple interactions |
ISO |
royal jelly inhibits the reaction [phenylhydrazine affects the expression of CCND1 mRNA] |
CTD |
PMID:35099105 |
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
E2f1 |
E2F transcription factor 1 |
multiple interactions |
EXP |
royal jelly inhibits the reaction [Paclitaxel results in increased expression of E2F1 mRNA] |
CTD |
PMID:27496854 |
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NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
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G |
Esr1 |
estrogen receptor 1 |
multiple interactions affects binding increases activity |
ISO |
Estradiol inhibits the reaction [royal jelly binds to ESR1 protein]; royal jelly binds to and results in increased activity of ESR1 protein; royal jelly inhibits the reaction [Estradiol binds to ESR1 protein] royal jelly results in increased activity of ESR1 protein |
CTD |
PMID:15946813 PMID:17287592 |
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NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Esr2 |
estrogen receptor 2 |
multiple interactions affects binding |
ISO |
Estradiol inhibits the reaction [royal jelly binds to ESR2 protein]; royal jelly binds to and results in increased activity of ESR2 protein; royal jelly inhibits the reaction [Estradiol binds to ESR2 protein] |
CTD |
PMID:15946813 PMID:17287592 |
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NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
multiple interactions |
EXP |
royal jelly inhibits the reaction [Fluorides results in increased expression of GSK3B protein] |
CTD |
PMID:34227456 |
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NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
Ins1 |
insulin 1 |
multiple interactions |
EXP |
royal jelly inhibits the reaction [Fructose results in increased expression of INS1 protein] |
CTD |
PMID:18981581 |
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NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
multiple interactions decreases expression |
ISO EXP |
royal jelly inhibits the reaction [phenylhydrazine results in decreased expression of MYC mRNA] royal jelly inhibits the reaction [Paclitaxel results in decreased expression of MYC mRNA] royal jelly results in decreased expression of MYC mRNA |
CTD |
PMID:27496854 PMID:35099105 |
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NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
EXP |
royal jelly inhibits the reaction [Fluorides results in decreased expression of NFE2L2 protein] |
CTD |
PMID:34227456 |
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions |
ISO |
royal jelly inhibits the reaction [Nicotine results in decreased expression of PCNA protein] |
CTD |
PMID:30896085 |
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NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
EXP |
royal jelly inhibits the reaction [Fluorides results in increased expression of RELA protein] |
CTD |
PMID:34227456 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Tff1 |
trefoil factor 1 |
increases expression |
ISO |
royal jelly results in increased expression of TFF1 mRNA |
CTD |
PMID:15946813 |
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NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
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G |
Tp53 |
tumor protein p53 |
multiple interactions |
ISO |
royal jelly inhibits the reaction [Nicotine results in increased expression of TRP53 mRNA] |
CTD |
PMID:30896085 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Vegfa |
vascular endothelial growth factor A |
increases expression |
ISO EXP |
royal jelly results in increased expression of VEGFA mRNA |
CTD |
PMID:15946813 PMID:17287592 |
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO EXP |
[Tetradecanoylphorbol Acetate co-treated with Calcimycin] inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]; HDAC5 protein inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]; semaglutide inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein] |
CTD |
PMID:36075570 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Casp3 |
caspase 3 |
multiple interactions |
ISO EXP |
[Tetradecanoylphorbol Acetate co-treated with Calcimycin] inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]]; HDAC5 protein inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]]; semaglutide inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein] |
CTD |
PMID:36075570 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Hdac5 |
histone deacetylase 5 |
multiple interactions |
EXP ISO |
semaglutide inhibits the reaction [Lipopolysaccharides results in increased expression of HDAC5 protein] [Tetradecanoylphorbol Acetate co-treated with Calcimycin] inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased expression of HDAC5 protein]]; HDAC5 protein inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]; HDAC5 protein inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]]; HDAC5 protein inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; HDAC5 protein inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]]; HDAC5 protein inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]]; HDAC5 protein inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; semaglutide inhibits the reaction [Lipopolysaccharides results in increased expression of HDAC5 protein] |
CTD |
PMID:36075570 |
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NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO EXP |
[Tetradecanoylphorbol Acetate co-treated with Calcimycin] inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]]; HDAC5 protein inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]]; semaglutide inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] semaglutide inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] |
CTD |
PMID:36075570 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
[Tetradecanoylphorbol Acetate co-treated with Calcimycin] inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; HDAC5 protein inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; semaglutide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:36075570 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
[Tetradecanoylphorbol Acetate co-treated with Calcimycin] inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]]; HDAC5 protein inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]]; semaglutide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein] |
CTD |
PMID:36075570 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP ISO |
semaglutide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] [Tetradecanoylphorbol Acetate co-treated with Calcimycin] inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; HDAC5 protein inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; semaglutide inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] |
CTD |
PMID:36075570 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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