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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:3-methoxytyramine
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Accession:CHEBI:1582 term browser browse the term
Definition:A monomethoxybenzene that is dopamine in which the hydroxy group at position 3 is replaced by a methoxy group. It is a metabolite of the neurotransmitter dopamine and considered a potential biomarker of pheochromocytomas and paragangliomas.
Synonyms:related_synonym: 2-(4-hydroxy-3-methoxyphenyl)ethylamine;   2-methoxy-4-(2-aminoethyl)phenol;   3-MT;   3-O-Methyldopamine;   3-methoxy-4-hydroxyphenethylamine;   3-methoxy-p-tyramine;   3-methoxydopamine;   3MT;   4-(2-Amino-ethyl)-2-methoxy-phenol;   4-(2-aminoethyl)-2-methoxyphenol;   4-(2-azanylethyl)-2-methoxy-phenol;   4-hydroxy-3-methoxy-2-phenethylamine;   4-hydroxy-3-methoxy-beta-phenethylamine;   4-hydroxy-3-methoxyphenethylamine;   4-hydroxy-3-methoxyphenylethylamine;   5-(2-Aminoethyl)guaiacol;   Formula=C9H13NO2;   InChI=1S/C9H13NO2/c1-12-9-6-7(4-5-10)2-3-8(9)11/h2-3,6,11H,4-5,10H2,1H3;   InChIKey=DIVQKHQLANKJQO-UHFFFAOYSA-N;   SMILES=C1(=CC(=CC=C1O)CCN)OC;   beta-(4-hydroxy-3-methoxyphenyl)ethylamine;   homovanillinamine;   homovanillylamine
 xref: CAS:554-52-9;   Chemspider:1606;   FooDB:FDB021876;   HMDB:HMDB0000022;   KEGG:C05587;   KNApSAcK:C00042132
 xref_mesh: MESH:C001746
 xref: PMCID:PMC2965771;   PMID:12105105;   PMID:12138004;   PMID:12649306;   PMID:15120096;   PMID:15542730;   PMID:15556832;   PMID:17954499;   PMID:19309105;   PMID:19897674;   PMID:20976142;   PMID:22008135;   PMID:22563039;   PMID:262188;   PMID:26425473;   PMID:26680494;   PMID:27208558;   PMID:27235704;   PMID:2927387;   PMID:29274926;   PMID:30813742;   PMID:30904545;   PMID:31724812;   PMID:31872013;   PMID:32101397;   PMID:32829134;   PMID:33096053;   PMID:33279210;   PMID:33927450;   PMID:33993248;   PMID:34110302;   PMID:3434205;   PMID:34454132;   PMID:34486152;   PMID:34570657;   PMID:34820673;   PMID:35085004;   PMID:35234981;   PMID:35343638;   PMID:35598694;   PMID:4073504;   PMID:4281061;   PMID:6749220;   PMID:7004664;   PMID:7251775;   PMID:872373;   PMID:9834968;   Wikipedia:3-Methoxytyramine
 cyclic_relationship: is_conjugate_base_of CHEBI:192089


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3-methoxytyramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Taar1 trace-amine-associated receptor 1 increases activity
multiple interactions		 ISO 3-methoxytyramine results in increased activity of TAAR1 protein
[3-methoxytyramine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP		 CTD PMID:19725810 NCBI chr 1:21,517,742...21,518,740
Ensembl chr 1:21,517,258...21,532,084 		JBrowse link
G Vdr vitamin D receptor multiple interactions
increases abundance		 ISO Calcitriol promotes the reaction [VDR protein results in increased abundance of 3-methoxytyramine] CTD PMID:27450565 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      application 19689
        indicator 8776
          biomarker 6589
            3-methoxytyramine 2
              3-methoxytyramine sulfate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    main group molecular entity 19811
                      s-block molecular entity 19647
                        hydrogen molecular entity 19628
                          hydrides 19139
                            inorganic hydride 18156
                              pnictogen hydride 18146
                                nitrogen hydride 18059
                                  azane 17866
                                    ammonia 17865
                                      organic amino compound 17865
                                        aralkylamino compound 1074
                                          monoamine 639
                                            monoamine molecular messenger 639
                                              catecholamine 582
                                                dopamine 379
                                                  3-methoxytyramine 2
                                                    3-methoxytyramine sulfate 0
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