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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:thiosemicarbazone
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Accession:CHEBI:156467 term browser browse the term
Definition:A hydrazone resulting from the formal condensation of an aldehyde or ketone with the non-thioacylated nitrogen of thiosemicarbazide or its substituted derivatives.
Synonyms:related_synonym: Formula=C2N3SR5;   SMILES=[*]\\C([*])=N\\N([*])C(=S)N([*])[*];   thiosemicarbazone derivative;   thiosemicarbazone derivatives;   thiosemicarbazones
 xref: Wikipedia:Thiosemicarbazone


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Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G H2ax H2A.X variant histone increases expression ISO 3-aminopyridine-2-carboxaldehyde thiosemicarbazone results in increased expression of H2AX protein CTD PMID:25130544 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239 		JBrowse link
G Prdx3 peroxiredoxin 3 increases oxidation ISO 3-aminopyridine-2-carboxaldehyde thiosemicarbazone results in increased oxidation of PRDX3 protein CTD PMID:21195754 NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111 		JBrowse link
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B multiple interactions ISO [Cisplatin co-treated with 3-aminopyridine-2-carboxaldehyde thiosemicarbazone] results in increased expression of RRM2B protein CTD PMID:20954859 NCBI chr 7:69,077,024...69,108,742
Ensembl chr 7:69,078,291...69,108,633 		JBrowse link
G Txn2 thioredoxin 2 increases oxidation
multiple interactions		 ISO 3-aminopyridine-2-carboxaldehyde thiosemicarbazone results in increased oxidation of TXN2 protein
[3-aminopyridine-2-carboxaldehyde thiosemicarbazone binds to Iron] which results in increased oxidation of TXN2 protein		 CTD PMID:21195754 NCBI chr 7:109,496,772...109,510,378
Ensembl chr 7:109,496,761...109,510,359 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    chemical entity 19897
      atom 19897
        nonmetal atom 19819
          sulfur atom 17774
            sulfur molecular entity 17774
              organosulfur compound 17471
                thiosemicarbazone 4
                  (S)-citronellalthiosemicarbazonate + 0
                  triapine 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19776
                        carbon atom 19772
                          organic molecular entity 19772
                            heteroorganic entity 19532
                              organochalcogen compound 19293
                                organooxygen compound 19209
                                  carbon oxoacid 18678
                                    carboxylic acid 18675
                                      carboacyl group 17725
                                        univalent carboacyl group 17725
                                          carbamoyl group 17577
                                            carboxamide 17577
                                              monocarboxylic acid amide 15750
                                                urea 6233
                                                  ureas 6231
                                                    semicarbazide 68
                                                      semicarbazone 20
                                                        thiosemicarbazone 4
                                                          (S)-citronellalthiosemicarbazonate + 0
                                                          triapine 4
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