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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:dihydrofolic acid
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Accession:CHEBI:15633 term browser browse the term
Definition:A folic acid derivative acted upon by dihydrofolate reductase to produce tetrahydrofolic acid. It interacts with bacteria during cell division and is targeted by various drugs to prevent nucleic acid synthesis.
Synonyms:related_synonym: 7,8-Dihydrofolate;   7,8-Dihydrofolic acid;   7,8-Dihydropteroylglutamate;   Dihydrofolate;   N-(4-{[(2-amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid;   N-(7,8-dihydropteroyl)-L-glutamic acid
 alt_id: CHEBI:12245;   CHEBI:14150;   CHEBI:20768;   CHEBI:42000;   CHEBI:4564
 xref: CAS:4033-27-6;   DrugBank:DB02015;   KNApSAcK:C00007248
 xref_mesh: MESH:C010920
 xref: kegg.compound:C00415
 chemrof_formula: C19H21N7O6
 chemrof_inchi: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t12-/m0/s1
 chemrof_smiles: Nc1nc2c(c(=O)n1)N=C(CNc1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1)CN2
 chemrof_inchikey: OZRNSSUDZOLUSN-LBPRGKRZSA-N
 cyclic_relationship: is_conjugate_acid_of CHEBI:57451


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dihydrofolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmbs hydroxymethylbilane synthase increases activity EXP Dihydrofolic acid increases activity of purified Hmbs protein RGD PMID:593266 RGD:26884337 NCBI chr 8:53,570,364...53,577,758
Ensembl chr 8:53,570,364...53,577,802 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor decreases expression ISO dihydrofolate results in decreased expression of IGF1R mRNA CTD PMID:16728583 NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:130,959,997...131,248,664 		JBrowse link
G Nat1 N-acetyltransferase 1 decreases activity ISO dihydrofolate results in decreased activity of NAT1 protein CTD PMID:16003948 NCBI chr16:26,984,882...27,005,194
Ensembl chr16:26,982,625...26,986,527 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO dihydrofolate results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213 		JBrowse link
G Slc19a1 solute carrier family 19 member 1 multiple interactions
decreases activity 		EXP dihydrofolate inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]
dihydrofolate results in decreased activity of SLC19A1 protein 		CTD PMID:14612385 NCBI chr20:11,583,928...11,601,959
Ensembl chr20:11,583,929...11,601,488 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      biological role 20831
        biochemical role 19888
          metabolite 19624
            prokaryotic metabolite 17258
              bacterial metabolite 17258
                Escherichia coli metabolite 17053
                  dihydrofolic acid 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            organic molecule 20499
                              organic cyclic compound 20390
                                organic heterocyclic compound 19381
                                  organic heteropolycyclic compound 18616
                                    organic heterobicyclic compound 17442
                                      pteridines 10290
                                        pterins 9446
                                          folic acids 9443
                                            dihydrofolic acids 5
                                              dihydrofolic acid 5
paths to the root