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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:dihydrofolic acid
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Accession:CHEBI:15633 term browser browse the term
Definition:A folic acid derivative acted upon by dihydrofolate reductase to produce tetrahydrofolic acid. It interacts with bacteria during cell division and is targeted by various drugs to prevent nucleic acid synthesis.
Synonyms:exact_synonym: N-(4-{[(2-amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
 related_synonym: 7,8-Dihydrofolate;   7,8-Dihydrofolic acid;   7,8-Dihydropteroylglutamate;   Dihydrofolate;   Formula=C19H21N7O6;   InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t12-/m0/s1;   InChIKey=OZRNSSUDZOLUSN-LBPRGKRZSA-N;   N-(7,8-dihydropteroyl)-L-glutamic acid;   SMILES=Nc1nc2NCC(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)=Nc2c(=O)[nH]1
 alt_id: CHEBI:12245;   CHEBI:14150;   CHEBI:20768;   CHEBI:42000;   CHEBI:4564
 xref: CAS:4033-27-6;   DrugBank:DB02015;   KEGG:C00415;   KNApSAcK:C00007248
 xref_mesh: MESH:C010920
 cyclic_relationship: is_conjugate_acid_of CHEBI:57451


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dihydrofolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmbs hydroxymethylbilane synthase increases activity EXP Dihydrofolic acid increases activity of purified Hmbs protein RGD PMID:593266 RGD:26884337 NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor decreases expression ISO dihydrofolate results in decreased expression of IGF1R mRNA CTD PMID:16728583 NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Nat1 N-acetyltransferase 1 decreases activity ISO dihydrofolate results in decreased activity of NAT1 protein CTD PMID:16003948 NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO dihydrofolate results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Slc19a1 solute carrier family 19 member 1 multiple interactions
decreases activity		 EXP dihydrofolate inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]
dihydrofolate results in decreased activity of SLC19A1 protein		 CTD PMID:14612385 NCBI chr20:11,584,410...11,602,429
Ensembl chr20:11,584,411...11,601,972 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      biological role 19852
        biochemical role 19582
          metabolite 19562
            prokaryotic metabolite 18618
              bacterial metabolite 18592
                Escherichia coli metabolite 18527
                  dihydrofolic acid 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    main group molecular entity 19849
                      s-block molecular entity 19681
                        hydrogen molecular entity 19662
                          hydrides 19167
                            inorganic hydride 18182
                              pnictogen hydride 18172
                                nitrogen hydride 18085
                                  azane 17866
                                    ammonia 17865
                                      organic amino compound 17888
                                        amino acid 16071
                                          alpha-amino acid 13929
                                            L-alpha-amino acid 12971
                                              glutamine family amino acid 10316
                                                L-glutamic acid 10255
                                                  L-glutamic acid derivative 9425
                                                    folic acids 9408
                                                      dihydrofolic acids 5
                                                        dihydrofolic acid 5
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