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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:12(S)-HPETE
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Accession:CHEBI:15626 term browser browse the term
Definition:The (S)-enantiomer of 12-HPETE.
Synonyms:related_synonym: (5Z,8Z,10E,14Z)-(12S)-12-Hydroperoxyeicosa-5,8,10,14-tetraenoate;   (5Z,8Z,10E,14Z)-(12S)-12-Hydroperoxyicosa-5,8,10,14-tetraenoate;   (5Z,8Z,10E,14Z)-(12S)-12-Hydroperoxyicosa-5,8,10,14-tetraenoic acid;   12-Hpete;   12-Hydroperoxyeicosatetraenoate;   12-Hydroperoxyeicosatetraenoic acid;   12-Hydroperoxyicosatetraenoate;   12-Hydroperoxyicosatetraenoic acid;   12-Oohete;   Arachidonic acid omega-9 hydroperoxide;   Formula=C20H32O4;   InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1;   InChIKey=ZIOZYRSDNLNNNJ-LQWMCKPYSA-N;   SMILES=CCCCC\\C=C/C[C@H](OO)\\C=C\\C=C/C\\C=C/CCCC(O)=O;   omega-9 Hpaa;   omega-9-Hydroperoxyarachidonic acid
 alt_id: CHEBI:10907;   CHEBI:18593;   CHEBI:19137;   CHEBI:250;   CHEBI:740
 xref: CAS:67675-13-2;   KEGG:C05965;   LIPID_MAPS_instance:LMFA03060013;   LIPID_MAPS_instance:LMFA03060042
 xref_mesh: MESH:C021201
 cyclic_relationship: is_conjugate_acid_of CHEBI:57444;   is_enantiomer_of CHEBI:34145


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12(S)-HPETE term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpx1 glutathione peroxidase 1 increases response to substance ISO GPX1 protein results in increased susceptibility to 12-HPETE CTD PMID:11115402 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gpx4 glutathione peroxidase 4 increases chemical synthesis ISO GPX4 protein results in increased chemical synthesis of 12-HPETE CTD PMID:11115402 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO 12-HPETE inhibits the reaction [Sodium Salicylate inhibits the reaction [PTGS2 protein results in increased metabolism of Arachidonic Acid]]; 12-HPETE inhibits the reaction [Sodium Salicylate results in decreased activity of PTGS2 protein] CTD PMID:12538810 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19917
    role 19887
      biological role 19885
        biochemical role 19569
          metabolite 19577
            eukaryotic metabolite 19378
              animal metabolite 19265
                mammalian metabolite 19264
                  mouse metabolite 18956
                    12(S)-HPETE 3
                      12(S)-HPETE methyl ester 0
                      N-[(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-icosatetraenoyl]-gamma-aminobutanoic acid 0
                      N-[(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-icosatetraenoyl]alanine 0
                      N-[(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-icosatetraenoyl]glycine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19917
    subatomic particle 19915
      composite particle 19915
        hadron 19915
          baryon 19915
            nucleon 19915
              atomic nucleus 19915
                atom 19915
                  main group element atom 19855
                    p-block element atom 19855
                      carbon group element atom 19774
                        carbon atom 19790
                          organic molecular entity 19790
                            heteroorganic entity 19549
                              organochalcogen compound 19309
                                organooxygen compound 19204
                                  carbon oxoacid 18689
                                    carboxylic acid 18686
                                      monocarboxylic acid 18026
                                        fatty acid 16849
                                          unsaturated fatty acid 1684
                                            polyunsaturated fatty acid 847
                                              fatty acid 20:4 364
                                                icosatetraenoic acid 364
                                                  icosa-5,8,10,14-tetraenoic acid 3
                                                    12(S)-HPETE 3
                                                      12(S)-HPETE methyl ester 0
                                                      N-[(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-icosatetraenoyl]-gamma-aminobutanoic acid 0
                                                      N-[(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-icosatetraenoyl]alanine 0
                                                      N-[(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-icosatetraenoyl]glycine 0
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