topoisomerase II inhibitor - Ontology Report

fostriecin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Benzo(a)pyrene results in increased expression of BBC3 protein]]

NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509

Casp3

caspase 3

multiple interactions

fostriecin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Benzo(a)pyrene results in increased cleavage of CASP3 protein]]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

Foxo3

forkhead box O3

multiple interactions

fostriecin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of FOXO3 protein]]

NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561

Tp53

tumor protein p53

multiple interactions

fostriecin promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [Benzo(a)pyrene results in increased expression of TP53 protein]]

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

vosaroxin

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Arnt

aryl hydrocarbon receptor nuclear translocator

multiple interactions

vosaroxin inhibits the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to ARNT protein]]

NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580

Casp3

caspase 3

increases activity

vosaroxin results in increased activity of CASP3 protein

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

Hif1a

hypoxia inducible factor 1 subunit alpha

multiple interactions
decreases expression

dorsomorphin inhibits the reaction [vosaroxin results in decreased expression of HIF1A protein]; SIRT3 protein inhibits the reaction [vosaroxin results in decreased expression of HIF1A protein]; vosaroxin inhibits the reaction [Oxygen deficiency affects the localization of HIF1A protein]; vosaroxin inhibits the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to ARNT protein]]

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

Idh2

isocitrate dehydrogenase (NADP(+)) 2

increases activity
multiple interactions

vosaroxin results in increased activity of IDH2 protein
SIRT2 protein affects the reaction [vosaroxin results in increased activity of IDH2 protein]

NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025

Sirt2

sirtuin 2

multiple interactions

SIRT2 protein affects the reaction [vosaroxin results in increased activity of IDH2 protein]; SIRT2 protein affects the reaction [vosaroxin results in increased activity of SOD2 protein]

NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975

Sirt3

sirtuin 3

multiple interactions

SIRT3 protein inhibits the reaction [vosaroxin results in decreased expression of HIF1A protein]

NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808

Sod2

superoxide dismutase 2

increases activity
multiple interactions

vosaroxin results in increased activity of SOD2 protein
SIRT2 protein affects the reaction [vosaroxin results in increased activity of SOD2 protein]