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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:lumefantrine
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Accession:CHEBI:156095 term browser browse the term
Definition:A member of the class of fluorenes that is 9-(p-chlorobenzylidene)-9H-fluorene which is substitutec by chlorine at positions 2 and 7, and by a 2-(dibutylamino)-1-hydroxyethyl group at position 4. An antimalarial drug used in combination with artemether for the treatment of multi-drug resistant strains of falciparum malaria.
Synonyms:exact_synonym: 2-(dibutylamino)-1-[(9Z)-2,7-dichloro-9-(4-chlorobenzylidene)-9H-fluoren-4-yl]ethanol
 related_synonym: (+-)-2,7-Dichloro-9-((Z)-p-chlorobenzylidene)-alpha-((dibutylamino)methyl)fluorene-4-methanol;   2-Dibutylamino-1-[2,7-dichloro-9-(4-chloro-benzylidene)-9H-fluoren-4-yl]-ethanol;   2-Dibutylamino-1-{2,7-dichloro-9-[1-(4-chloro-phenyl)-meth-(Z)-ylidene]-9H-fluoren-4-yl}-ethanol;   Benflumetol;   Formula=C30H32Cl3NO;   InChI=1S/C30H32Cl3NO/c1-3-5-13-34(14-6-4-2)19-29(35)28-18-23(33)17-27-25(15-20-7-9-21(31)10-8-20)26-16-22(32)11-12-24(26)30(27)28/h7-12,15-18,29,35H,3-6,13-14,19H2,1-2H3/b25-15-;   InChIKey=DYLGFOYVTXJFJP-MYYYXRDXSA-N;   SMILES=CCCCN(CCCC)CC(O)c1cc(Cl)cc2\\C(=C/c3ccc(Cl)cc3)c3cc(Cl)ccc3-c12;   dl-Benflumelol
 xref: Beilstein:8811003;   CAS:82186-77-4;   DrugBank:DB06708;   Drug_Central:1617;   KEGG:D03821
 xref_mesh: MESH:D000078102
 xref: PMID:12565929;   PMID:12699750;   PMID:12798326;   Wikipedia:Lumefantrine


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lumefantrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fshb follicle stimulating hormone subunit beta decreases secretion EXP Lumefantrine results in decreased secretion of FSHB protein CTD PMID:26811345 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Prl prolactin increases secretion EXP Lumefantrine results in increased secretion of PRL protein CTD PMID:26811345 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19867
    role 19837
      biological role 19835
        xenobiotic 18714
          fluorenes 428
            lumefantrine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19867
    subatomic particle 19865
      composite particle 19865
        hadron 19865
          baryon 19865
            nucleon 19865
              atomic nucleus 19865
                atom 19865
                  main group element atom 19803
                    main group molecular entity 19803
                      s-block molecular entity 19638
                        hydrogen molecular entity 19620
                          hydrides 19141
                            organic hydride 18692
                              organic fundamental parent 18692
                                hydrocarbon 18446
                                  cyclic hydrocarbon 17235
                                    arene 17216
                                      polycyclic arene 17040
                                        ortho-fused polycyclic arene 9839
                                          fluorene 557
                                            fluorenes 428
                                              lumefantrine 2
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