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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:acetoacetic acid
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Accession:CHEBI:15344 term browser browse the term
Definition:A 3-oxo monocarboxylic acid that is butyric acid bearing a 3-oxo substituent.
Synonyms:related_synonym: 3-Ketobutyric acid;   3-Oxobutanoic acid;   3-Oxobutyric acid;   3-ketobutanoic acid;   Formula=C4H6O3;   InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7);   InChIKey=WDJHALXBUFZDSR-UHFFFAOYSA-N;   SMILES=CC(=O)CC(O)=O;   beta-Ketobutyric acid
 alt_id: CHEBI:22172;   CHEBI:2391;   CHEBI:40507
 xref: CAS:541-50-4;   DrugBank:DB01762;   HMDB:HMDB0000060;   KEGG:C00164;   KNApSAcK:C00007458;   LIPID_MAPS_instance:LMFA01060003
 xref_mesh: MESH:C016635
 xref: MetaCyc:3-KETOBUTYRATE;   PMID:17190852;   PMID:20444635;   PMID:21806064;   PMID:22382897;   PMID:3884391;   Reaxys:1747690;   UM-BBD_compID:c0069;   Wikipedia:Acetoacetic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:13705;   is_tautomer_of CHEBI:131367


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acetoacetic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 increases secretion ISO acetoacetic acid results in increased secretion of CCL2 protein CTD PMID:17665966 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Il6 interleukin 6 increases secretion ISO acetoacetic acid results in increased secretion of IL6 protein CTD PMID:17665966 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Slc13a5 solute carrier family 13 member 5 decreases abundance ISO SLC13A5 protein results in decreased abundance of acetoacetic acid CTD PMID:32634519 NCBI chr10:56,866,249...56,891,189
Ensembl chr10:56,866,249...56,890,945 		JBrowse link
acetoacetyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 affects binding ISO acetoacetyl CoA binds to HSD17B2 protein CTD PMID:25526675 NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      biological role 19842
        biochemical role 19549
          metabolite 19537
            acetoacetic acid 4
              (R)-acetoacetylcarnitine 0
              2-methylacetoacetic acid + 0
              acetoacetamide 0
              acetoacetyl group + 0
              acetoacetyl-CoA 1
              ethyl acetoacetate 0
              geranyl acetoacetate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            heteroorganic entity 19505
                              organochalcogen compound 19268
                                organooxygen compound 19184
                                  carbon oxoacid 18654
                                    carboxylic acid 18651
                                      monocarboxylic acid 18000
                                        fatty acid 16833
                                          short-chain fatty acid 15925
                                            fatty acid 4:0 8229
                                              butyric acid 6727
                                                acetoacetic acid 4
                                                  (R)-acetoacetylcarnitine 0
                                                  2-methylacetoacetic acid + 0
                                                  acetoacetamide 0
                                                  acetoacetyl group + 0
                                                  acetoacetyl-CoA 1
                                                  ethyl acetoacetate 0
                                                  geranyl acetoacetate 0
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