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G |
Abcb11 |
ATP binding cassette subfamily B member 11 |
increases expression multiple interactions affects activity decreases expression |
EXP ISO |
Emodin results in increased expression of ABCB11 mRNA; Emodin results in increased expression of ABCB11 protein 2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside affects the reaction [[Emodin affects the activity of ABCB11 protein] which affects the export of Taurocholic Acid]; [2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased expression of ABCB11 protein; [Emodin affects the activity of ABCB11 protein] which affects the export of Taurocholic Acid dorsomorphin inhibits the reaction [Emodin results in decreased expression of ABCB11 mRNA]; Emodin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of ABCB11 mRNA] Emodin results in decreased expression of ABCB11 mRNA; Emodin results in decreased expression of ABCB11 protein |
CTD |
PMID:28161596 PMID:30517764 PMID:35753641 |
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NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions increases expression |
ISO EXP |
Emodin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] Emodin results in increased expression of ABCB1A mRNA ABCB1A protein promotes the reaction [Emodin results in increased export of calcein AM] |
CTD |
PMID:19549930 PMID:24380838 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcb1b |
ATP-binding cassette, sub-family B member 1B |
increases expression |
EXP |
Emodin results in increased expression of ABCB1B mRNA |
CTD |
PMID:19549930 |
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NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
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G |
Abcb4 |
ATP binding cassette subfamily B member 4 |
decreases expression |
EXP |
Emodin results in decreased expression of ABCB4 mRNA |
CTD |
PMID:28161596 |
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NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
increases expression multiple interactions decreases expression |
EXP ISO |
Emodin results in increased expression of ABCC2 mRNA [2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in decreased expression of ABCC2 protein; [2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased expression of ABCC2 protein Emodin results in decreased expression of ABCC2 mRNA Emodin results in decreased expression of ABCC2 mRNA; Emodin results in decreased expression of ABCC2 protein |
CTD |
PMID:19549930 PMID:28161596 PMID:30517764 PMID:35753641 |
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
Abcc3 |
ATP binding cassette subfamily C member 3 |
increases expression multiple interactions decreases expression |
EXP ISO |
Emodin results in increased expression of ABCC3 mRNA [2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in decreased expression of ABCC3 protein; [2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased expression of ABCC3 protein Emodin results in decreased expression of ABCC3 mRNA Emodin results in decreased expression of ABCC3 mRNA; Emodin results in decreased expression of ABCC3 protein |
CTD |
PMID:19549930 PMID:28161596 PMID:30517764 PMID:35753641 |
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NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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G |
Abcc4 |
ATP binding cassette subfamily C member 4 |
decreases expression multiple interactions |
EXP ISO |
Emodin results in decreased expression of ABCC4 mRNA; Emodin results in decreased expression of ABCC4 protein [2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased expression of ABCC4 protein Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC4 mRNA] |
CTD |
PMID:28161596 PMID:30517764 PMID:35753641 |
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NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
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G |
Abcc6 |
ATP binding cassette subfamily C member 6 |
increases expression |
EXP |
Emodin results in increased expression of ABCC6 mRNA |
CTD |
PMID:19549930 |
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NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464
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G |
Acta1 |
actin, alpha 1, skeletal muscle |
decreases expression |
ISO |
Emodin results in decreased expression of ACTA1 mRNA |
CTD |
PMID:16045814 |
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NCBI chr19:51,883,709...51,886,735
Ensembl chr19:51,883,715...51,886,742
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G |
Acta2 |
actin alpha 2, smooth muscle |
decreases expression multiple interactions |
EXP |
Emodin results in decreased expression of ACTA2 protein 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; Emodin inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]] |
CTD |
PMID:15288473 PMID:27989784 |
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NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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G |
Adgre1 |
adhesion G protein-coupled receptor E1 |
multiple interactions |
ISO |
Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ADGRE1 protein] |
CTD |
PMID:37023836 |
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NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000
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G |
Agt |
angiotensinogen |
multiple interactions |
EXP |
Emodin inhibits the reaction [AGT protein results in increased expression of MYC protein]; Emodin inhibits the reaction [AGT protein results in increased expression of PCNA protein] |
CTD |
PMID:17886230 |
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NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
ISO |
Emodin binds to and results in increased activity of AHR protein Emodin binds to and results in increased activity of AHR protein; Emodin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] |
CTD |
PMID:14644660 PMID:17869316 |
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NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Akr1b10 |
aldo-keto reductase family 1 member B10 |
decreases activity |
ISO |
Emodin results in decreased activity of AKR1B10 protein |
CTD |
PMID:35065925 |
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NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
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G |
Akr1c3 |
aldo-keto reductase family 1, member C3 |
decreases activity |
ISO |
Emodin results in decreased activity of AKR1C3 protein |
CTD |
PMID:35065925 |
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NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
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G |
Akr7a3 |
aldo-keto reductase family 7 member A3 |
decreases activity |
ISO |
Emodin results in decreased activity of AKR7A3 protein |
CTD |
PMID:35065925 |
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NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions decreases phosphorylation decreases expression |
ISO EXP |
[arsenic trioxide co-treated with IFNA2 protein co-treated with Docosahexaenoic Acids co-treated with Emodin] results in decreased expression of AKT1 protein; Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of AKT1 protein]; SB 203580 promotes the reaction [Emodin results in decreased phosphorylation of AKT1 protein]; U 0126 promotes the reaction [Emodin results in decreased phosphorylation of AKT1 protein] Emodin results in decreased expression of AKT1 mRNA Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:15288473 PMID:16045814 PMID:17077332 PMID:23848338 PMID:27032576 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Ar |
androgen receptor |
multiple interactions |
ISO |
Emodin inhibits the reaction [cobaltous chloride results in increased expression of AR protein] |
CTD |
PMID:23212659 |
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NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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G |
Arg2 |
arginase 2 |
decreases expression |
ISO |
Emodin results in decreased expression of ARG2 mRNA |
CTD |
PMID:21319176 |
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NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378
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G |
Arid3a |
AT-rich interaction domain 3A |
increases expression |
ISO |
Emodin results in increased expression of ARID3A mRNA |
CTD |
PMID:15612046 |
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NCBI chr 7:9,755,291...9,781,260
Ensembl chr 7:9,755,294...9,780,599
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G |
Atm |
ATM serine/threonine kinase |
increases expression increases phosphorylation |
ISO |
Emodin results in increased expression of ATM mRNA Emodin results in increased phosphorylation of ATM protein |
CTD |
PMID:16045814 PMID:20855424 |
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NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
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G |
Bag5 |
BAG cochaperone 5 |
decreases expression |
ISO |
Emodin results in decreased expression of BAG5 mRNA |
CTD |
PMID:16045814 |
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NCBI chr 6:130,768,467...130,772,122
Ensembl chr 6:130,768,141...130,772,970
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G |
Bax |
BCL2 associated X, apoptosis regulator |
affects expression increases expression multiple interactions decreases expression |
ISO EXP |
Emodin affects the expression of BAX protein Emodin results in increased expression of BAX protein 2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside promotes the reaction [Emodin results in increased expression of BAX protein] Emodin results in decreased expression of BAX protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Emodin affects the expression of BAX protein]; SB 203580 affects the reaction [Emodin affects the expression of BAX protein]; U 0126 affects the reaction [Emodin affects the expression of BAX protein] |
CTD |
PMID:19549930 PMID:27032576 PMID:35753641 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression multiple interactions affects expression |
ISO EXP |
Emodin results in decreased expression of BCL2 mRNA; Emodin results in decreased expression of BCL2 protein [2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in decreased expression of BCL2 protein Emodin affects the expression of BCL2 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Emodin affects the expression of BCL2 protein]; SB 203580 affects the reaction [Emodin affects the expression of BCL2 protein]; U 0126 affects the reaction [Emodin affects the expression of BCL2 protein] |
CTD |
PMID:19549930 PMID:23848338 PMID:27032576 PMID:35753641 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bfar |
bifunctional apoptosis regulator |
decreases expression |
ISO |
Emodin results in decreased expression of BFAR mRNA |
CTD |
PMID:16045814 |
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NCBI chr10:1,552,019...1,585,040
Ensembl chr10:1,552,072...1,585,038
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G |
Bid |
BH3 interacting domain death agonist |
increases degradation multiple interactions |
ISO |
Emodin results in increased degradation of BID protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased degradation of BID protein]; SB 203580 promotes the reaction [Emodin results in increased degradation of BID protein] |
CTD |
PMID:27032576 |
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NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
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G |
Birc5 |
baculoviral IAP repeat-containing 5 |
decreases expression |
ISO |
Emodin results in decreased expression of BIRC5 mRNA; Emodin results in decreased expression of BIRC5 protein |
CTD |
PMID:23848338 |
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NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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G |
Canx |
calnexin |
decreases expression |
ISO |
Emodin results in decreased expression of CANX mRNA |
CTD |
PMID:16045814 |
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NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821
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G |
Casp1 |
caspase 1 |
increases expression multiple interactions |
ISO |
Emodin results in increased expression of CASP1 mRNA Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased cleavage of CASP1 protein] |
CTD |
PMID:15612046 PMID:37023836 |
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NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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G |
Casp12 |
caspase 12 |
decreases expression |
ISO |
Emodin results in decreased expression of CASP12 mRNA |
CTD |
PMID:21319176 |
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NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
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G |
Casp3 |
caspase 3 |
increases expression multiple interactions affects expression increases cleavage increases activity |
ISO EXP |
Emodin results in increased expression of CASP3 protein [2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased cleavage of CASP3 protein; Emodin inhibits the reaction [Hydrogen Peroxide results in decreased expression of and results in increased cleavage of CASP3 protein]; Emodin inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]; Emodin inhibits the reaction [Oxidopamine results in decreased expression of and results in increased cleavage of CASP3 protein]; Emodin inhibits the reaction [Oxidopamine results in increased activity of CASP3 protein] Emodin affects the expression of CASP3 protein modified form Emodin results in increased cleavage of CASP3 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased cleavage of CASP3 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Emodin results in increased activity of CASP3 protein]; Emodin results in increased cleavage of and results in increased activity of CASP3 protein; SB 203580 inhibits the reaction [Emodin results in increased cleavage of CASP3 protein]; U 0126 promotes the reaction [Emodin results in increased cleavage of CASP3 protein] |
CTD |
PMID:19549930 PMID:23848338 PMID:25448808 PMID:27032576 PMID:34492313 PMID:34971761 PMID:35753641 More...
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp8 |
caspase 8 |
multiple interactions increases activity |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased activity of CASP8 protein]; SB 203580 promotes the reaction [Emodin results in increased activity of CASP8 protein]; U 0126 promotes the reaction [Emodin results in increased activity of CASP8 protein] |
CTD |
PMID:27032576 |
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
increases expression multiple interactions |
ISO EXP |
Emodin results in increased expression of CASP9 mRNA [2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased cleavage of CASP9 protein |
CTD |
PMID:21319176 PMID:35753641 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
multiple interactions affects expression |
ISO EXP |
Emodin inhibits the reaction [Tobacco Smoke Pollution results in decreased activity of CAT protein] Emodin promotes the reaction [Cisplatin results in decreased activity of CAT protein] Emodin affects the expression of CAT protein |
CTD |
PMID:19549930 PMID:22271272 PMID:26139382 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Cbr1 |
carbonyl reductase 1 |
decreases activity |
ISO |
Emodin results in decreased activity of CBR1 protein |
CTD |
PMID:35065925 |
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NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393 Ensembl chr11:32,908,950...32,911,393 Ensembl chr11:32,908,950...32,911,393
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G |
Ccl26 |
C-C motif chemokine ligand 26 |
multiple interactions |
ISO |
Emodin inhibits the reaction [CCL26 protein binds to and results in increased activity of CCR3 protein] |
CTD |
PMID:37788752 |
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NCBI chr12:21,109,384...21,114,336
Ensembl chr12:21,109,421...21,114,335
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G |
Ccnb2 |
cyclin B2 |
decreases expression |
ISO |
Emodin results in decreased expression of CCNB2 mRNA |
CTD |
PMID:16045814 |
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NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874
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G |
Ccr3 |
C-C motif chemokine receptor 3 |
multiple interactions |
ISO |
Emodin inhibits the reaction [CCL26 protein binds to and results in increased activity of CCR3 protein] |
CTD |
PMID:37788752 |
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NCBI chr 8:123,586,100...123,634,178
Ensembl chr 8:123,616,236...123,634,990
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G |
Cdh1 |
cadherin 1 |
increases expression multiple interactions |
EXP |
Emodin results in increased expression of CDH1 protein 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]; Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]] |
CTD |
PMID:27989784 |
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NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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G |
Cdk13 |
cyclin-dependent kinase 13 |
decreases expression |
ISO |
Emodin results in decreased expression of CDK13 mRNA |
CTD |
PMID:16045814 |
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NCBI chr17:47,251,145...47,344,675
Ensembl chr17:47,251,163...47,341,721
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G |
Cdk4 |
cyclin-dependent kinase 4 |
decreases expression |
ISO |
Emodin results in decreased expression of CDK4 mRNA |
CTD |
PMID:16045814 |
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NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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G |
Cdkn1c |
cyclin-dependent kinase inhibitor 1C |
increases expression |
ISO |
Emodin results in increased expression of CDKN1C mRNA |
CTD |
PMID:21319176 |
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NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048
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G |
Celsr3 |
cadherin, EGF LAG seven-pass G-type receptor 3 |
decreases expression |
ISO |
Emodin results in decreased expression of CELSR3 mRNA |
CTD |
PMID:16045814 |
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NCBI chr 8:109,530,597...109,558,360
Ensembl chr 8:109,530,641...109,558,354
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G |
Chia |
chitinase, acidic |
multiple interactions |
ISO |
Emodin inhibits the reaction [Ovalbumin results in increased expression of CHIA mRNA] |
CTD |
PMID:22484343 |
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NCBI chr 2:193,614,374...193,656,532
Ensembl chr 2:193,614,114...193,656,533
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G |
Cidec |
cell death-inducing DFFA-like effector c |
decreases expression |
ISO |
Emodin results in decreased expression of CIDEC mRNA |
CTD |
PMID:21319176 |
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NCBI chr 4:146,569,288...146,582,173
Ensembl chr 4:146,569,289...146,582,173
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G |
Col1a1 |
collagen type I alpha 1 chain |
decreases expression |
EXP |
Emodin results in decreased expression of COL1A1 mRNA |
CTD |
PMID:15288473 |
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NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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G |
Col1a2 |
collagen type I alpha 2 chain |
multiple interactions |
EXP |
Emodin inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA] |
CTD |
PMID:19474275 |
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NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
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G |
Col3a1 |
collagen type III alpha 1 chain |
decreases expression |
EXP |
Emodin results in decreased expression of COL3A1 mRNA |
CTD |
PMID:15288473 |
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NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
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G |
Cops5 |
COP9 signalosome subunit 5 |
multiple interactions |
ISO |
[arsenic trioxide co-treated with IFNA2 protein co-treated with Docosahexaenoic Acids co-treated with Emodin] results in decreased expression of COPS5 protein |
CTD |
PMID:17077332 |
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NCBI chr 5:9,192,233...9,210,498
Ensembl chr 5:9,192,100...9,210,731
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G |
Csnk2a1 |
casein kinase 2 alpha 1 |
increases expression |
ISO |
Emodin results in increased expression of CSNK2A1 mRNA |
CTD |
PMID:21319176 |
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NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696
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G |
Csnk2b |
casein kinase 2 beta |
increases expression |
ISO |
Emodin results in increased expression of CSNK2B mRNA |
CTD |
PMID:21319176 |
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NCBI chr20:3,700,363...3,705,331
Ensembl chr20:3,698,733...3,707,133
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G |
Ctsd |
cathepsin D |
decreases expression |
ISO |
Emodin results in decreased expression of CTSD mRNA |
CTD |
PMID:16045814 |
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NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
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G |
Cxcl1 |
C-X-C motif chemokine ligand 1 |
multiple interactions |
EXP |
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CXCL1 mRNA] |
CTD |
PMID:18590720 |
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NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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G |
Cxcl2 |
C-X-C motif chemokine ligand 2 |
multiple interactions |
EXP |
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CXCL2 mRNA] |
CTD |
PMID:18590720 |
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NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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G |
Cyld |
CYLD lysine 63 deubiquitinase |
increases expression |
ISO |
Emodin results in increased expression of CYLD mRNA |
CTD |
PMID:21319176 |
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NCBI chr19:18,310,632...18,373,696
Ensembl chr19:18,314,019...18,373,658
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions decreases activity increases expression |
ISO |
Emodin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] Emodin results in decreased activity of CYP1A1 protein Emodin results in increased expression of CYP1A1 mRNA; Emodin results in increased expression of CYP1A1 protein |
CTD |
PMID:11502733 PMID:14644660 PMID:17012224 PMID:27633141 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
multiple interactions increases hydroxylation increases oxidation decreases activity |
ISO |
[CYP1A2 protein co-treated with Acetylcysteine] results in increased metabolism of Emodin metabolite CYP1A2 protein results in increased hydroxylation of Emodin CYP1A2 protein results in increased oxidation of Emodin Emodin results in decreased activity of CYP1A2 protein |
CTD |
PMID:27633141 PMID:27989148 PMID:30672276 PMID:33438235 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
increases expression decreases activity |
ISO |
Emodin results in increased expression of CYP1B1 mRNA; Emodin results in increased expression of CYP1B1 protein Emodin results in decreased activity of CYP1B1 protein |
CTD |
PMID:11502733 PMID:14990334 PMID:27633141 |
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NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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G |
Cyp27a1 |
cytochrome P450, family 27, subfamily a, polypeptide 1 |
decreases expression multiple interactions |
EXP ISO |
Emodin results in decreased expression of CYP27A1 mRNA [2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased expression of CYP27A1 protein |
CTD |
PMID:28161596 PMID:30517764 PMID:35753641 |
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NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
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G |
Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
increases oxidation decreases activity multiple interactions |
ISO |
CYP2C19 protein results in increased oxidation of Emodin Emodin results in decreased activity of CYP2C19 protein [CYP2C19 protein co-treated with Acetylcysteine] results in increased metabolism of Emodin metabolite |
CTD |
PMID:27989148 PMID:33438235 |
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NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
decreases activity |
ISO |
Emodin results in decreased activity of CYP2D6 protein |
CTD |
PMID:33438235 |
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NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions decreases activity affects response to substance increases hydroxylation increases oxidation |
ISO |
[CYP3A4 protein co-treated with Acetylcysteine] results in increased metabolism of Emodin metabolite Emodin results in decreased activity of CYP3A4 protein CYP3A4 protein affects the susceptibility to Emodin CYP3A4 protein results in increased hydroxylation of Emodin CYP3A4 protein results in increased oxidation of Emodin |
CTD |
PMID:27989148 PMID:30672276 PMID:33438235 PMID:34875353 |
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Cyp3a9 |
cytochrome P450, family 3, subfamily a, polypeptide 9 |
increases hydroxylation |
ISO |
CYP3A5 protein results in increased hydroxylation of Emodin |
CTD |
PMID:30672276 |
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NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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G |
Cyp7a1 |
cytochrome P450 family 7 subfamily A member 1 |
decreases expression multiple interactions |
EXP |
Emodin results in decreased expression of CYP7A1 mRNA; Emodin results in decreased expression of CYP7A1 protein [2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased expression of CYP7A1 protein |
CTD |
PMID:28161596 PMID:35753641 |
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NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
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G |
Cyp7b1 |
cytochrome P450 family 7 subfamily B member 1 |
decreases expression |
ISO |
Emodin results in decreased expression of CYP7B1 mRNA |
CTD |
PMID:30517764 |
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NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698
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G |
Cyp8b1 |
cytochrome P450 family 8 subfamily B member 1 |
decreases expression |
EXP |
Emodin results in decreased expression of CYP8B1 mRNA; Emodin results in decreased expression of CYP8B1 protein |
CTD |
PMID:28161596 |
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NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
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G |
Dct |
dopachrome tautomerase |
decreases expression |
ISO |
Emodin results in decreased expression of DCT mRNA; Emodin results in decreased expression of DCT protein |
CTD |
PMID:26972667 |
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NCBI chr15:95,062,006...95,100,863
Ensembl chr15:95,062,003...95,100,836
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
increases expression |
EXP |
Emodin results in increased expression of DDIT3 protein |
CTD |
PMID:19549930 |
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NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Dhfr |
dihydrofolate reductase |
decreases expression |
ISO |
Emodin results in decreased expression of DHFR mRNA |
CTD |
PMID:16045814 |
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NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713
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G |
Dnajb1 |
DnaJ heat shock protein family (Hsp40) member B1 |
increases expression |
ISO |
Emodin results in increased expression of DNAJB1 mRNA |
CTD |
PMID:16045814 |
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NCBI chr19:24,522,731...24,526,419
Ensembl chr19:24,522,717...24,526,458
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G |
Dync1h1 |
dynein cytoplasmic 1 heavy chain 1 |
increases expression |
ISO |
Emodin results in increased expression of DYNC1H1 mRNA |
CTD |
PMID:21319176 |
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NCBI chr 6:129,615,208...129,680,888
Ensembl chr 6:129,609,397...129,680,883
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G |
E2f5 |
E2F transcription factor 5 |
increases expression |
ISO |
Emodin results in increased expression of E2F5 mRNA |
CTD |
PMID:16045814 |
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NCBI chr 2:86,997,331...87,012,908
Ensembl chr 2:86,997,332...87,012,990
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G |
Egr1 |
early growth response 1 |
multiple interactions |
EXP |
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of EGR1 mRNA] |
CTD |
PMID:18590720 |
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NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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G |
Ei24 |
EI24, autophagy associated transmembrane protein |
increases expression |
ISO |
Emodin results in increased expression of EI24 mRNA |
CTD |
PMID:16045814 |
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NCBI chr 8:36,494,289...36,510,653
Ensembl chr 8:36,494,289...36,510,571
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G |
Eif2b1 |
eukaryotic translation initiation factor 2B subunit alpha |
decreases expression |
ISO |
Emodin results in decreased expression of EIF2B1 mRNA |
CTD |
PMID:16045814 |
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NCBI chr12:32,025,593...32,033,848
Ensembl chr12:32,025,557...32,046,601
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G |
Esr1 |
estrogen receptor 1 |
increases activity |
ISO |
Emodin results in increased activity of ESR1 protein |
CTD |
PMID:19161236 |
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NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Esr2 |
estrogen receptor 2 |
increases activity |
ISO |
Emodin results in increased activity of ESR2 protein |
CTD |
PMID:19161236 |
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NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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G |
Fabp5 |
fatty acid binding protein 5 |
decreases expression |
ISO |
Emodin results in decreased expression of FABP5 mRNA |
CTD |
PMID:15612046 |
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NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773
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G |
Fadd |
Fas associated via death domain |
increases expression |
ISO |
Emodin results in increased expression of FADD mRNA |
CTD |
PMID:21319176 |
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NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
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G |
Fas |
Fas cell surface death receptor |
multiple interactions decreases expression increases expression |
ISO EXP |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased expression of FAS protein]; U 0126 promotes the reaction [Emodin results in increased expression of FAS protein] Emodin results in decreased expression of FAS protein |
CTD |
PMID:19549930 PMID:27032576 |
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NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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G |
Faslg |
Fas ligand |
multiple interactions increases expression |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased expression of FASLG protein]; SB 203580 promotes the reaction [Emodin results in increased expression of FASLG protein]; U 0126 promotes the reaction [Emodin results in increased expression of FASLG protein] |
CTD |
PMID:27032576 |
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NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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G |
Fn1 |
fibronectin 1 |
decreases expression |
EXP |
Emodin results in decreased expression of FN1 mRNA |
CTD |
PMID:15288473 |
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NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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G |
Foxo1 |
forkhead box O1 |
increases expression |
ISO |
Emodin results in increased expression of FOXO1 mRNA |
CTD |
PMID:16045814 |
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NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
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G |
Gadd45a |
growth arrest and DNA-damage-inducible, alpha |
multiple interactions |
ISO |
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of GADD45A mRNA] |
CTD |
PMID:30517764 |
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NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
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G |
Gas2 |
growth arrest-specific 2 |
increases expression |
ISO |
Emodin results in increased expression of GAS2 mRNA |
CTD |
PMID:16045814 |
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NCBI chr 1:101,452,361...101,582,619
Ensembl chr 1:101,482,591...101,582,619
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
increases expression |
EXP |
Emodin results in increased expression of GCLC mRNA |
CTD |
PMID:34971761 |
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NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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G |
Gclm |
glutamate cysteine ligase, modifier subunit |
increases expression |
EXP |
Emodin results in increased expression of GCLM mRNA |
CTD |
PMID:34971761 |
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NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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G |
Gcnt2 |
glucosaminyl (N-acetyl) transferase 2 |
increases expression |
ISO |
Emodin results in increased expression of GCNT2 mRNA |
CTD |
PMID:15612046 |
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NCBI chr17:23,796,859...23,901,625
Ensembl chr17:23,796,859...23,901,611
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G |
Gfap |
glial fibrillary acidic protein |
multiple interactions |
EXP |
Emodin inhibits the reaction [Oxaliplatin results in increased expression of GFAP protein]; Emodin inhibits the reaction [TNF protein results in increased expression of GFAP protein] |
CTD |
PMID:36184831 |
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NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
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G |
Golga3 |
golgin A3 |
increases expression |
ISO |
Emodin results in increased expression of GOLGA3 mRNA |
CTD |
PMID:21319176 |
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NCBI chr12:46,452,409...46,500,509
Ensembl chr12:46,454,870...46,500,509 Ensembl chr 4:46,454,870...46,500,509
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
ISO |
[Emodin co-treated with 1-aminobenzotriazole] results in increased expression of GPT protein; Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of GPT protein] |
CTD |
PMID:34492313 PMID:37023836 |
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NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Gpx1 |
glutathione peroxidase 1 |
increases expression |
ISO |
Emodin results in increased expression of GPX1 mRNA |
CTD |
PMID:16045814 |
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NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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G |
Gpx2 |
glutathione peroxidase 2 |
multiple interactions |
ISO |
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of GPX2 mRNA] |
CTD |
PMID:30517764 |
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NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
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G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
ISO |
Emodin promotes the reaction [Cisplatin results in decreased activity of GSR protein] |
CTD |
PMID:22271272 |
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NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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G |
Gstm5 |
glutathione S-transferase, mu 5 |
decreases expression |
ISO |
Emodin results in decreased expression of GSTM3 mRNA |
CTD |
PMID:16045814 |
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NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553
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G |
Gstp1 |
glutathione S-transferase pi 1 |
multiple interactions |
ISO |
Emodin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GSTP1 mRNA]; Emodin inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA] |
CTD |
PMID:15313406 |
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NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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G |
H2ax |
H2A.X variant histone |
increases expression multiple interactions |
ISO |
Emodin results in increased expression of H2AX protein; Emodin results in increased expression of H2AX protein modified form TOP2A affects the reaction [Emodin results in increased expression of H2AX protein modified form] |
CTD |
PMID:20855424 PMID:34492313 PMID:36893906 |
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NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 Ensembl chr 4:44,671,786...44,673,239
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G |
Hacd3 |
3-hydroxyacyl-CoA dehydratase 3 |
decreases expression |
ISO |
Emodin results in decreased expression of HACD3 mRNA |
CTD |
PMID:16045814 |
|
NCBI chr 8:65,501,240...65,538,507
Ensembl chr 8:65,501,240...65,538,507
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions |
ISO |
Emodin inhibits the reaction [Oxygen deficiency results in decreased expression of HIF1A mRNA] |
CTD |
PMID:21382473 |
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NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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G |
Hils1 |
histone linker H1 domain, spermatid-specific 1 |
increases expression |
ISO |
Emodin results in increased expression of H1F9 mRNA |
CTD |
PMID:21319176 |
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NCBI chr10:79,913,525...79,914,321
Ensembl chr10:79,913,480...79,914,321
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G |
Hk2 |
hexokinase 2 |
increases expression |
ISO |
Emodin results in increased expression of HK2 mRNA |
CTD |
PMID:21319176 |
|
NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions increases expression |
ISO |
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of HMOX1 mRNA]; Emodin promotes the reaction [Tobacco Smoke Pollution results in increased expression of HMOX1 mRNA]; Emodin promotes the reaction [Tobacco Smoke Pollution results in increased expression of HMOX1 protein] Emodin results in increased expression of HMOX1 mRNA |
CTD |
PMID:26139382 PMID:30517764 PMID:34875353 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hnf4a |
hepatocyte nuclear factor 4, alpha |
decreases expression affects glucuronidation |
EXP ISO |
Emodin results in decreased expression of HNF4A protein Emodin results in decreased expression of HNF4A mRNA; Emodin results in decreased expression of HNF4A protein HNF4A gene SNP affects the glucuronidation of Emodin |
CTD |
PMID:32538071 |
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NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
increases expression |
EXP |
Emodin results in increased expression of HSPA5 protein |
CTD |
PMID:19549930 |
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NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
EXP |
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ICAM1 protein] |
CTD |
PMID:18590720 |
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NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Igsf11 |
immunoglobulin superfamily, member 11 |
increases expression |
ISO |
Emodin results in increased expression of IGSF11 mRNA |
CTD |
PMID:21319176 |
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NCBI chr11:61,733,139...61,884,059
Ensembl chr11:61,733,144...61,868,348
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G |
Il10 |
interleukin 10 |
multiple interactions |
ISO |
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL10 mRNA] |
CTD |
PMID:30517764 |
|
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il13 |
interleukin 13 |
multiple interactions |
ISO |
Emodin inhibits the reaction [Ovalbumin results in increased secretion of IL13 protein] |
CTD |
PMID:22484343 |
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NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
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G |
Il15 |
interleukin 15 |
increases expression |
ISO |
Emodin results in increased expression of IL15 mRNA |
CTD |
PMID:15612046 |
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NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820
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G |
Il18 |
interleukin 18 |
multiple interactions |
ISO |
Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL18 protein] |
CTD |
PMID:37023836 |
|
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO EXP |
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL1B mRNA]; Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL1B mRNA]; Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL1B protein]; Emodin inhibits the reaction [Tobacco Smoke Pollution results in increased secretion of IL1B protein] Emodin inhibits the reaction [Oxaliplatin results in increased expression of IL1B protein]; Emodin inhibits the reaction [TNF protein results in increased expression of IL1B protein] |
CTD |
PMID:26139382 PMID:30517764 PMID:36184831 PMID:37023836 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il4 |
interleukin 4 |
multiple interactions |
ISO |
Emodin inhibits the reaction [Ovalbumin results in increased secretion of IL4 protein] |
CTD |
PMID:22484343 |
|
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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G |
Il5 |
interleukin 5 |
multiple interactions |
ISO |
Emodin inhibits the reaction [Ovalbumin results in increased secretion of IL5 protein] |
CTD |
PMID:22484343 |
|
NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
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G |
Il6 |
interleukin 6 |
multiple interactions |
EXP ISO |
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL6 protein] Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL6 mRNA]; Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL6 protein]; Emodin inhibits the reaction [Tobacco Smoke Pollution results in increased secretion of IL6 protein] Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of AKT1 protein]; Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of JAK1 protein]; Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of JAK2 protein]; Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein] |
CTD |
PMID:18590720 PMID:23848338 PMID:26139382 PMID:30517764 PMID:37023836 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Itpr1 |
inositol 1,4,5-trisphosphate receptor, type 1 |
decreases expression |
ISO |
Emodin results in decreased expression of ITPR1 mRNA |
CTD |
PMID:16045814 |
|
NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491
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G |
Jag1 |
jagged canonical Notch ligand 1 |
multiple interactions decreases expression |
EXP |
2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of JAG1 protein]]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of JAG1 protein] Emodin results in decreased expression of JAG1 protein |
CTD |
PMID:27989784 |
|
NCBI chr 3:124,406,783...124,442,220
Ensembl chr 3:124,406,794...124,442,209
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G |
Jak1 |
Janus kinase 1 |
decreases phosphorylation multiple interactions |
ISO |
Emodin results in decreased phosphorylation of JAK1 protein Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of JAK1 protein] |
CTD |
PMID:23848338 |
|
NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926
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G |
Jak2 |
Janus kinase 2 |
decreases phosphorylation multiple interactions |
ISO |
Emodin results in decreased phosphorylation of JAK2 protein Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of JAK2 protein] |
CTD |
PMID:23848338 |
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NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
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G |
Jund |
JunD proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
[arsenic trioxide co-treated with IFNA2 protein co-treated with Docosahexaenoic Acids co-treated with Emodin] results in decreased expression of JUND protein |
CTD |
PMID:17077332 |
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NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799
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G |
Krt19 |
keratin 19 |
decreases expression |
ISO |
Emodin results in decreased expression of KRT19 mRNA |
CTD |
PMID:16045814 |
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NCBI chr10:85,075,835...85,080,552
Ensembl chr10:85,066,802...85,171,799
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G |
Laptm5 |
lysosomal protein transmembrane 5 |
increases expression |
ISO |
Emodin results in increased expression of LAPTM5 mRNA |
CTD |
PMID:15612046 |
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NCBI chr 5:143,087,759...143,109,807
Ensembl chr 5:143,087,759...143,109,807
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G |
Lef1 |
lymphoid enhancer binding factor 1 |
decreases expression |
ISO |
Emodin results in decreased expression of LEF1 mRNA |
CTD |
PMID:15612046 |
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NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794
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G |
Lrp1 |
LDL receptor related protein 1 |
multiple interactions |
ISO |
[Emodin co-treated with cobaltous chloride] results in increased expression of LRP1 protein |
CTD |
PMID:23212659 |
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NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910
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G |
Macf1 |
microtubule-actin crosslinking factor 1 |
decreases expression |
ISO |
Emodin results in decreased expression of MACF1 mRNA |
CTD |
PMID:16045814 |
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NCBI chr 5:135,623,734...135,949,097
Ensembl chr 5:135,623,742...135,945,905
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G |
Maob |
monoamine oxidase B |
decreases activity |
EXP |
Emodin results in decreased activity of MAOB protein |
CTD |
PMID:15120460 |
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NCBI chr X:5,907,327...6,010,996
Ensembl chr X:5,907,266...6,011,003
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G |
Map2k1 |
mitogen activated protein kinase kinase 1 |
multiple interactions |
EXP |
Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K1 protein] |
CTD |
PMID:15288473 |
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NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
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G |
Map2k2 |
mitogen activated protein kinase kinase 2 |
multiple interactions |
EXP |
Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K2 protein] |
CTD |
PMID:15288473 |
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NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions decreases phosphorylation increases phosphorylation |
EXP ISO |
Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein] Emodin results in decreased phosphorylation of MAPK1 protein Emodin results in increased phosphorylation of MAPK1 protein 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Emodin results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in decreased phosphorylation of MAPK1 protein]; [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with T0901317] inhibits the reaction [Emodin results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:15288473 PMID:26972667 PMID:27032576 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk10 |
mitogen activated protein kinase 10 |
increases expression |
ISO |
Emodin results in increased expression of MAPK10 mRNA |
CTD |
PMID:15612046 |
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NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201
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G |
Mapk14 |
mitogen activated protein kinase 14 |
multiple interactions |
ISO |
Acetylcysteine inhibits the reaction [Emodin promotes the reaction [arsenic trioxide results in increased phosphorylation of and results in increased activity of MAPK14 protein]]; Emodin promotes the reaction [arsenic trioxide results in increased phosphorylation of and results in increased activity of MAPK14 protein] |
CTD |
PMID:14729614 |
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NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions decreases phosphorylation increases phosphorylation |
EXP ISO |
Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein] Emodin results in decreased phosphorylation of MAPK3 protein Emodin results in increased phosphorylation of MAPK3 protein 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Emodin results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in decreased phosphorylation of MAPK3 protein]; [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with T0901317] inhibits the reaction [Emodin results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:15288473 PMID:26972667 PMID:27032576 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapt |
microtubule-associated protein tau |
decreases expression |
ISO |
Emodin results in decreased expression of MAPT mRNA |
CTD |
PMID:16045814 |
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NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
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G |
Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
decreases expression increases expression |
ISO |
Emodin results in decreased expression of MCL1 mRNA; Emodin results in decreased expression of MCL1 protein Emodin results in increased expression of MCL1 mRNA |
CTD |
PMID:21319176 PMID:23848338 |
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NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
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G |
Melk |
maternal embryonic leucine zipper kinase |
decreases expression |
ISO |
Emodin results in decreased expression of MELK mRNA; Emodin results in decreased expression of MELK protein |
CTD |
PMID:36893906 |
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NCBI chr 5:58,540,393...58,600,562
Ensembl chr 5:58,540,449...58,600,937
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G |
Mgmt |
O-6-methylguanine-DNA methyltransferase |
increases expression |
EXP |
Emodin results in increased expression of MGMT mRNA |
CTD |
PMID:19549930 |
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NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
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G |
Mitf |
melanocyte inducing transcription factor |
decreases expression |
ISO |
Emodin results in decreased expression of MITF protein |
CTD |
PMID:26972667 |
|
NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145
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G |
Mpo |
myeloperoxidase |
multiple interactions |
EXP |
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased activity of MPO protein] |
CTD |
PMID:18590720 |
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NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Muc5ac |
mucin 5AC, oligomeric mucus/gel-forming |
multiple interactions |
ISO |
Emodin inhibits the reaction [Ovalbumin results in increased expression of MUC5AC mRNA] |
CTD |
PMID:22484343 |
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NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475
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G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
multiple interactions affects expression |
EXP |
Emodin inhibits the reaction [AGT protein results in increased expression of MYC protein] Emodin affects the expression of MYC protein |
CTD |
PMID:17886230 PMID:19549930 |
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NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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G |
Mylk |
myosin light chain kinase |
increases activity |
EXP |
Emodin results in increased activity of MYLK protein |
CTD |
PMID:15133857 |
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NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261
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G |
Ncoa2 |
nuclear receptor coactivator 2 |
increases expression |
ISO |
Emodin results in increased expression of NCOA2 mRNA |
CTD |
PMID:21319176 |
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NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions affects localization |
ISO EXP |
Emodin promotes the reaction [Tobacco Smoke Pollution results in increased expression of and results in increased activity of NFE2L2 protein]; Emodin promotes the reaction [Tobacco Smoke Pollution results in increased expression of NFE2L2 mRNA] Emodin affects the localization of NFE2L2 protein [[Emodin inhibits the reaction [PKM protein binds to PKM protein binds to PKM protein binds to PKM protein]] results in increased abundance of [PKM protein binds to PKM protein]] which binds to NFE2L2 protein; Emodin affects the localization of [PKM protein binds to NFE2L2 protein]; Emodin promotes the reaction [PKM protein binds to NFE2L2 protein] |
CTD |
PMID:26139382 PMID:34971761 |
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
increases expression multiple interactions |
EXP ISO |
Emodin results in increased expression of NFKB1 protein Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NFKB1 mRNA] |
CTD |
PMID:19549930 PMID:37023836 |
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NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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G |
Nfkbia |
NFKB inhibitor alpha |
increases expression multiple interactions |
ISO |
Emodin results in increased expression of NFKBIA mRNA Emodin inhibits the reaction [Ovalbumin results in increased phosphorylation of and results in increased degradation of NFKBIA protein] |
CTD |
PMID:16045814 PMID:22484343 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nkx6-2 |
NK6 homeobox 2 |
increases expression |
ISO |
Emodin results in increased expression of NKX6-2 mRNA |
CTD |
PMID:15612046 |
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NCBI chr 1:194,380,149...194,383,533
Ensembl chr 1:194,381,975...194,383,515
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G |
Nlrp3 |
NLR family, pyrin domain containing 3 |
multiple interactions |
ISO |
Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NLRP3 mRNA] |
CTD |
PMID:37023836 |
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NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions affects expression |
EXP |
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NOS2 protein] Emodin affects the expression of NOS2 |
CTD |
PMID:18590720 PMID:23615023 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Notch1 |
notch receptor 1 |
decreases expression multiple interactions decreases response to substance |
EXP |
Emodin results in decreased expression of NOTCH1 protein 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of NOTCH1 protein]]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of and affects the localization of NOTCH1 protein]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]]; NOTCH1 protein inhibits the reaction [Emodin results in decreased activity of TGFB1 protein] NOTCH1 protein results in decreased susceptibility to Emodin |
CTD |
PMID:27989784 |
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NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression multiple interactions |
ISO EXP |
Emodin results in increased expression of NQO1 mRNA Emodin results in increased expression of and results in increased activity of NQO1 protein |
CTD |
PMID:34875353 PMID:34971761 |
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NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Nr0b2 |
nuclear receptor subfamily 0, group B, member 2 |
increases expression |
ISO |
Emodin results in increased expression of NR0B2 mRNA |
CTD |
PMID:30517764 |
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NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
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G |
Nr1h3 |
nuclear receptor subfamily 1, group H, member 3 |
increases expression |
ISO |
Emodin results in increased expression of NR1H3 mRNA; Emodin results in increased expression of NR1H3 protein |
CTD |
PMID:26972667 |
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NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722
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G |
Nr1h4 |
nuclear receptor subfamily 1, group H, member 4 |
decreases expression |
ISO |
Emodin results in decreased expression of NR1H4 mRNA; Emodin results in decreased expression of NR1H4 protein |
CTD |
PMID:30517764 |
|
NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
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G |
Oma1 |
OMA1 zinc metallopeptidase |
multiple interactions |
EXP |
Emodin inhibits the reaction [Hydrogen Peroxide results in increased expression of OMA1 protein]; Emodin inhibits the reaction [Oxidopamine results in increased expression of OMA1 protein] |
CTD |
PMID:34971761 |
|
NCBI chr 5:118,083,728...118,136,980
Ensembl chr 5:118,083,728...118,136,980
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases activity increases cleavage multiple interactions |
ISO |
Emodin results in increased activity of PARP1 protein Emodin results in increased cleavage of PARP1 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased cleavage of PARP1 protein]; [U 0126 co-treated with Emodin] results in increased cleavage of PARP1 protein; SB 203580 inhibits the reaction [Emodin results in increased cleavage of PARP1 protein]; U 0126 inhibits the reaction [Emodin results in increased cleavage of PARP1 protein] |
CTD |
PMID:23848338 PMID:27032576 PMID:34492313 PMID:36893906 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions |
EXP |
Emodin inhibits the reaction [AGT protein results in increased expression of PCNA protein] |
CTD |
PMID:17886230 |
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NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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G |
Pdcl |
phosducin like |
decreases expression |
ISO |
Emodin results in decreased expression of PDCL mRNA |
CTD |
PMID:16045814 |
|
NCBI chr 3:21,110,165...21,119,763
Ensembl chr 3:21,110,167...21,119,715 Ensembl chr 3:21,110,167...21,119,715
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G |
Pdgfb |
platelet derived growth factor subunit B |
multiple interactions |
EXP |
Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of AKT1 protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K1 protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K2 protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of RAF1 protein] |
CTD |
PMID:15288473 |
|
NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
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G |
Pdgfrb |
platelet derived growth factor receptor beta |
multiple interactions decreases expression |
EXP |
Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein] Emodin results in decreased expression of PDGFRB protein |
CTD |
PMID:15288473 |
|
NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843
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G |
Pecam1 |
platelet and endothelial cell adhesion molecule 1 |
decreases expression |
ISO |
Emodin results in decreased expression of PECAM1 protein |
CTD |
PMID:23848338 |
|
NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
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G |
Pik3c3 |
phosphatidylinositol 3-kinase, catalytic subunit type 3 |
increases expression |
ISO |
Emodin results in increased expression of PIK3C3 mRNA |
CTD |
PMID:16045814 |
|
NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048
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G |
Pik3r1 |
phosphoinositide-3-kinase regulatory subunit 1 |
affects expression |
EXP |
Emodin affects the expression of PIK3R1 protein |
CTD |
PMID:19549930 |
|
NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631
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G |
Pkm |
pyruvate kinase M1/2 |
affects localization decreases activity multiple interactions |
EXP |
Emodin affects the localization of PKM protein Emodin results in decreased activity of PKM protein [[Emodin inhibits the reaction [PKM protein binds to PKM protein binds to PKM protein binds to PKM protein]] results in increased abundance of [PKM protein binds to PKM protein]] which binds to NFE2L2 protein; [[Emodin inhibits the reaction [PKM protein binds to PKM protein binds to PKM protein binds to PKM protein]] results in increased abundance of [PKM protein binds to PKM protein]] which results in decreased activity of PKM protein; [Emodin inhibits the reaction [PKM protein binds to PKM protein binds to PKM protein binds to PKM protein]] results in increased abundance of [PKM protein binds to PKM protein]; Emodin affects the localization of [PKM protein binds to NFE2L2 protein]; Emodin inhibits the reaction [PKM protein binds to PKM protein binds to PKM protein binds to PKM protein]; Emodin promotes the reaction [PKM protein binds to NFE2L2 protein] |
CTD |
PMID:34971761 |
|
NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
increases expression multiple interactions |
ISO |
Emodin results in increased expression of PPARG protein Emodin results in increased stability of and results in increased expression of PPARG mRNA |
CTD |
PMID:25448808 |
|
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Ppm1d |
protein phosphatase, Mg2+/Mn2+ dependent, 1D |
increases expression |
ISO |
Emodin results in increased expression of PPM1D mRNA |
CTD |
PMID:16045814 |
|
NCBI chr10:70,172,603...70,208,607
Ensembl chr10:70,172,603...70,208,607
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G |
Ppp1r1c |
protein phosphatase 1, regulatory (inhibitor) subunit 1C |
decreases expression |
ISO |
Emodin results in decreased expression of PPP1R1C mRNA |
CTD |
PMID:15612046 |
|
NCBI chr 3:64,616,700...64,719,696
Ensembl chr 3:64,616,700...64,724,104
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G |
Prdx6 |
peroxiredoxin 6 |
increases expression |
ISO |
Emodin results in increased expression of PRDX6 mRNA |
CTD |
PMID:16045814 |
|
NCBI chr13:73,528,746...73,539,295
Ensembl chr13:73,528,210...73,539,355
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G |
Prkca |
protein kinase C, alpha |
affects localization |
EXP |
Emodin affects the localization of PRKCA protein |
CTD |
PMID:15133857 |
|
NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
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G |
Prkcd |
protein kinase C, delta |
decreases expression affects expression |
ISO EXP |
Emodin results in decreased expression of PRKCD mRNA Emodin affects the expression of PRKCD protein |
CTD |
PMID:16045814 PMID:19549930 |
|
NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352
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G |
Prm3 |
protamine 3 |
increases expression |
ISO |
Emodin results in increased expression of PRM3 mRNA |
CTD |
PMID:21319176 |
|
NCBI chr10:4,877,471...4,877,985
Ensembl chr10:4,877,471...4,877,985
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
EXP |
Emodin inhibits the reaction [Oxaliplatin results in increased expression of PTGS2 protein]; Emodin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein] |
CTD |
PMID:36184831 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Ptk2 |
protein tyrosine kinase 2 |
affects expression |
EXP |
Emodin affects the expression of PTK2 protein |
CTD |
PMID:19549930 |
|
NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783
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G |
Ptpn6 |
protein tyrosine phosphatase, non-receptor type 6 |
increases expression multiple interactions |
ISO |
Emodin results in increased expression of PTPN6 protein PTPN6 mutant form inhibits the reaction [Emodin results in decreased phosphorylation of and results in decreased activity of STAT3 protein] |
CTD |
PMID:23848338 |
|
NCBI chr 4:157,526,034...157,550,783
Ensembl chr 4:157,526,035...157,550,984
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G |
Raf1 |
Raf-1 proto-oncogene, serine/threonine kinase |
decreases expression multiple interactions |
ISO EXP |
Emodin results in decreased expression of RAF1 mRNA Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of RAF1 protein] |
CTD |
PMID:15288473 PMID:16045814 |
|
NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
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G |
Rag1 |
recombination activating 1 |
decreases expression |
ISO |
Emodin results in decreased expression of RAG1 mRNA |
CTD |
PMID:15612046 |
|
NCBI chr 3:87,917,061...87,928,158
Ensembl chr 3:87,917,004...87,928,291
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G |
Rarb |
retinoic acid receptor, beta |
decreases expression |
ISO |
Emodin results in decreased expression of RARB mRNA |
CTD |
PMID:22609528 |
|
NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288
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G |
Rb1 |
RB transcriptional corepressor 1 |
decreases expression |
ISO |
Emodin results in decreased expression of RB1 mRNA |
CTD |
PMID:16045814 |
|
NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
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G |
Rcn2 |
reticulocalbin 2 |
increases expression |
ISO |
Emodin results in increased expression of RCN2 mRNA |
CTD |
PMID:16045814 |
|
NCBI chr 8:56,449,206...56,466,253
Ensembl chr 8:56,449,206...56,466,251
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions decreases localization |
EXP ISO |
Emodin affects the expression of and affects the localization of RELA protein; Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased localization of RELA protein]; Emodin inhibits the reaction [Oxaliplatin results in increased expression of RELA protein]; Emodin inhibits the reaction [TNF protein results in increased expression of RELA protein] Emodin results in decreased localization of RELA protein Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of RELA protein]; Emodin inhibits the reaction [Ovalbumin affects the localization of RELA protein] |
CTD |
PMID:18590720 PMID:19549930 PMID:22484343 PMID:30517764 PMID:36184831 PMID:37023836 More...
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Rhoa |
ras homolog family member A |
decreases expression |
ISO |
Emodin results in decreased expression of RHOA mRNA |
CTD |
PMID:16045814 |
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NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
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G |
Rock1 |
Rho-associated coiled-coil containing protein kinase 1 |
decreases expression |
ISO |
Emodin results in decreased expression of ROCK1 mRNA |
CTD |
PMID:16045814 |
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NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571
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G |
Rock2 |
Rho-associated coiled-coil containing protein kinase 2 |
decreases expression |
ISO |
Emodin results in decreased expression of ROCK2 mRNA |
CTD |
PMID:16045814 |
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NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031
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G |
Sae1 |
SUMO1 activating enzyme subunit 1 |
decreases expression |
ISO |
Emodin results in decreased expression of SAE1 mRNA |
CTD |
PMID:16045814 |
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NCBI chr 1:77,030,961...77,086,937
Ensembl chr 1:77,030,965...77,086,986
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G |
Serpine1 |
serpin family E member 1 |
multiple interactions |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Emodin inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]]; Emodin inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]; Emodin promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]] |
CTD |
PMID:14534369 |
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NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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G |
Slc10a1 |
solute carrier family 10 member 1 |
decreases expression multiple interactions |
EXP ISO |
Emodin results in decreased expression of SLC10A1 mRNA; Emodin results in decreased expression of SLC10A1 protein Emodin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA] |
CTD |
PMID:28161596 PMID:30517764 |
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NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
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G |
Slc22a6 |
solute carrier family 22 member 6 |
decreases activity |
ISO |
Emodin results in decreased activity of SLC22A6 protein |
CTD |
PMID:29045746 |
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NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
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G |
Slc22a8 |
solute carrier family 22 member 8 |
decreases activity |
ISO |
Emodin results in decreased activity of SLC22A8 protein |
CTD |
PMID:29045746 |
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NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
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G |
Slco1b2 |
solute carrier organic anion transporter family member 1B2 |
multiple interactions |
ISO |
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLCO1B2 mRNA] |
CTD |
PMID:30517764 |
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NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
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G |
Smcp |
sperm mitochondria-associated cysteine-rich protein |
increases expression |
ISO |
Emodin results in increased expression of SMCP mRNA |
CTD |
PMID:21319176 |
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NCBI chr 2:178,160,948...178,165,951
Ensembl chr 2:178,160,127...178,166,001
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G |
Snu13 |
small nuclear ribonucleoprotein 13 |
decreases expression |
ISO |
Emodin results in decreased expression of SNU13 mRNA |
CTD |
PMID:15612046 |
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NCBI chr 7:113,565,293...113,570,887
Ensembl chr 7:113,565,295...113,570,872 Ensembl chr 1:113,565,295...113,570,872
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G |
Sod1 |
superoxide dismutase 1 |
multiple interactions |
ISO |
Emodin inhibits the reaction [Oxygen deficiency results in decreased activity of SOD1 protein]; Emodin inhibits the reaction [Oxygen deficiency results in decreased expression of SOD1 mRNA] |
CTD |
PMID:21382473 |
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NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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G |
Sod2 |
superoxide dismutase 2 |
multiple interactions affects activity |
ISO EXP |
Emodin inhibits the reaction [Oxygen deficiency results in decreased activity of SOD2 protein]; Emodin inhibits the reaction [Oxygen deficiency results in decreased expression of SOD2 mRNA] Emodin affects the activity of SOD2 protein |
CTD |
PMID:21382473 PMID:23615023 |
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NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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G |
Src |
SRC proto-oncogene, non-receptor tyrosine kinase |
decreases phosphorylation |
ISO |
Emodin results in decreased phosphorylation of SRC protein |
CTD |
PMID:23848338 |
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NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
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G |
St8sia1 |
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 |
increases expression |
ISO |
Emodin results in increased expression of ST8SIA1 mRNA |
CTD |
PMID:16045814 |
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NCBI chr 4:175,782,989...175,921,338
Ensembl chr 4:175,789,947...175,920,708
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G |
Stat3 |
signal transducer and activator of transcription 3 |
affects localization multiple interactions |
ISO |
Emodin affects the localization of STAT3 protein Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]; Emodin results in decreased phosphorylation of and results in decreased activity of STAT3 protein; pervanadate inhibits the reaction [Emodin results in decreased phosphorylation of and results in decreased activity of STAT3 protein]; PTPN6 mutant form inhibits the reaction [Emodin results in decreased phosphorylation of and results in decreased activity of STAT3 protein] |
CTD |
PMID:23848338 |
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NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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G |
Stip1 |
stress-induced phosphoprotein 1 |
decreases expression |
ISO |
Emodin results in decreased expression of STIP1 mRNA |
CTD |
PMID:16045814 |
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NCBI chr 1:204,209,433...204,228,452
Ensembl chr 1:204,178,932...204,228,476
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G |
Sult1a1 |
sulfotransferase family 1A member 1 |
decreases activity |
ISO |
Emodin results in decreased activity of SULT1A1 protein |
CTD |
PMID:27633141 |
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NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
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G |
Supt20h |
SPT20 homolog, SAGA complex component |
increases expression |
ISO |
Emodin results in increased expression of SUPT20H mRNA |
CTD |
PMID:16045814 |
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NCBI chr 2:138,897,316...138,930,493
Ensembl chr 2:138,897,416...138,930,495
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G |
Taok3 |
TAO kinase 3 |
decreases expression |
ISO |
Emodin results in decreased expression of TAOK3 mRNA |
CTD |
PMID:16045814 |
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NCBI chr12:39,312,354...39,473,656
Ensembl chr12:39,314,027...39,461,244
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G |
Tbcc |
tubulin folding cofactor C |
decreases expression |
ISO |
Emodin results in decreased expression of TBCC mRNA |
CTD |
PMID:16045814 |
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NCBI chr 9:14,098,855...14,100,043
Ensembl chr 9:14,098,868...14,100,042
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G |
Tcfl5 |
transcription factor like 5 |
increases expression |
ISO |
Emodin results in increased expression of TCFL5 mRNA |
CTD |
PMID:15612046 |
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NCBI chr 3:167,734,471...167,754,174
Ensembl chr 3:167,734,473...167,754,282
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions decreases activity |
EXP |
2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]; 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of JAG1 protein]]; 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of NOTCH1 protein]]; 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]]; 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin results in decreased activity of TGFB1 protein]; Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of and affects the localization of NOTCH1 protein]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of JAG1 protein]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]; Emodin inhibits the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]]; NOTCH1 protein inhibits the reaction [Emodin results in decreased activity of TGFB1 protein] |
CTD |
PMID:15288473 PMID:19474275 PMID:27989784 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP ISO |
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TNF protein]; Emodin inhibits the reaction [Oxaliplatin results in increased expression of TNF protein]; Emodin inhibits the reaction [TNF protein results in increased expression of GFAP protein]; Emodin inhibits the reaction [TNF protein results in increased expression of IL1B protein]; Emodin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; Emodin inhibits the reaction [TNF protein results in increased expression of RELA protein] Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF mRNA]; Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; Emodin inhibits the reaction [Tobacco Smoke Pollution results in increased secretion of TNF protein] 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Emodin inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]]; Emodin inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA]; Emodin inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]; Emodin promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]] |
CTD |
PMID:14534369 PMID:15313406 PMID:18590720 PMID:26139382 PMID:36184831 PMID:37023836 More...
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Top2a |
DNA topoisomerase II alpha |
multiple interactions increases activity |
ISO |
Emodin inhibits the reaction [TOP2A results in increased hydrolysis of Adenosine Triphosphate]; TOP2A affects the reaction [Emodin results in increased expression of H2AX protein modified form] Emodin results in increased activity of TOP2A protein |
CTD |
PMID:20855424 |
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NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874
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G |
Tp53 |
tumor protein p53 |
affects expression |
EXP |
Emodin affects the expression of TP53 protein |
CTD |
PMID:19549930 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Tp63 |
tumor protein p63 |
increases expression |
ISO |
Emodin results in increased expression of TRP63 mRNA |
CTD |
PMID:15612046 |
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NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398
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G |
Traf2 |
Tnf receptor-associated factor 2 |
increases expression decreases expression |
ISO |
Emodin results in increased expression of TRAF2 mRNA Emodin results in decreased expression of TRAF2 mRNA |
CTD |
PMID:16045814 PMID:21319176 |
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NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538
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G |
Trpv2 |
transient receptor potential cation channel, subfamily V, member 2 |
increases expression |
ISO |
Emodin results in increased expression of TRPV2 mRNA |
CTD |
PMID:15612046 |
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NCBI chr10:47,265,524...47,294,263
Ensembl chr10:47,272,931...47,294,260
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G |
Tsga13 |
testis specific, 13 |
increases expression |
ISO |
Emodin results in increased expression of TSGA13 mRNA |
CTD |
PMID:21319176 |
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NCBI chr 4:59,501,773...59,522,925
Ensembl chr 4:59,501,774...59,522,818
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G |
Tubb3 |
tubulin, beta 3 class III |
decreases expression |
ISO |
Emodin results in decreased expression of TUBB3 mRNA |
CTD |
PMID:16045814 |
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NCBI chr19:51,457,187...51,466,243
Ensembl chr19:51,457,184...51,466,243
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G |
Txn1 |
thioredoxin 1 |
multiple interactions |
EXP |
Emodin results in increased expression of and results in increased activity of TXN protein |
CTD |
PMID:34971761 |
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NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
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G |
Txnl4b |
thioredoxin-like 4B |
decreases expression |
ISO |
Emodin results in decreased expression of TXNL4B mRNA |
CTD |
PMID:16045814 |
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NCBI chr19:37,530,157...37,539,827
Ensembl chr19:37,530,152...37,538,521
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G |
Txnrd1 |
thioredoxin reductase 1 |
decreases expression multiple interactions |
ISO EXP |
Emodin results in decreased expression of TXNRD1 mRNA Emodin results in increased expression of and results in increased activity of TXNRD1 protein |
CTD |
PMID:16045814 PMID:34971761 |
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NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
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G |
Tyr |
tyrosinase |
decreases activity |
ISO |
Emodin results in decreased activity of TYR protein |
CTD |
PMID:26972667 |
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NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207
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G |
Tyrp1 |
tyrosinase-related protein 1 |
decreases expression |
ISO |
Emodin results in decreased expression of TYRP1 mRNA; Emodin results in decreased expression of TYRP1 protein |
CTD |
PMID:26972667 |
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NCBI chr 5:95,280,982...95,299,516
Ensembl chr 5:95,280,982...95,299,516
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G |
Ube2i |
ubiquitin-conjugating enzyme E2I |
increases expression |
ISO |
Emodin results in increased expression of UBE2I mRNA |
CTD |
PMID:21319176 |
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NCBI chr10:14,277,749...14,294,681
Ensembl chr10:69,701,618...69,702,443 Ensembl chr10:69,701,618...69,702,443
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G |
Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
increases glucuronidation |
ISO |
UGT1A1 protein results in increased glucuronidation of Emodin |
CTD |
PMID:14557274 |
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NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a9 |
UDP glucuronosyltransferase family 1 member A9 |
increases glucuronidation |
ISO |
UGT1A9 protein results in increased glucuronidation of Emodin |
CTD |
PMID:14557274 PMID:24854283 |
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NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt2b15 |
UDP glucuronosyltransferase family 2 member B15 |
increases metabolic processing |
EXP |
UGT2B15 protein results in increased metabolism of Emodin |
CTD |
PMID:7574722 |
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NCBI chr14:20,768,015...20,783,599
Ensembl chr14:20,768,015...20,783,589
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G |
Ugt2b7 |
UDP glucuronosyltransferase family 2 member B7 |
decreases expression |
ISO EXP |
Emodin results in decreased expression of UGT2B7 mRNA; Emodin results in decreased expression of UGT2B7 protein |
CTD |
PMID:32538071 |
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NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
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G |
Vdac1 |
voltage-dependent anion channel 1 |
decreases expression |
ISO |
Emodin results in decreased expression of VDAC1 mRNA |
CTD |
PMID:16045814 |
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NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640
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G |
Vegfa |
vascular endothelial growth factor A |
decreases expression |
ISO |
Emodin results in decreased expression of VEGFA mRNA; Emodin results in decreased expression of VEGFA protein |
CTD |
PMID:23848338 |
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Vim |
vimentin |
decreases expression multiple interactions |
EXP |
Emodin results in decreased expression of VIM protein 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]] |
CTD |
PMID:27989784 |
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NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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G |
Xrcc1 |
X-ray repair cross complementing 1 |
affects expression |
EXP |
Emodin affects the expression of XRCC1 protein |
CTD |
PMID:19549930 |
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NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701
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G |
Zfp37 |
zinc finger protein 37 |
increases expression |
ISO |
Emodin results in increased expression of ZFP37 mRNA |
CTD |
PMID:21319176 |
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NCBI chr 5:75,598,732...75,638,896
Ensembl chr 5:75,598,732...75,638,942
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