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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Cryptotanshinone
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Accession:CHEBI:149838 term browser browse the term
Synonyms:related_synonym: Formula=C19H20O3;   InChI=1S/C19H20O3/c1-10-9-22-18-12-6-7-13-11(5-4-8-19(13,2)3)15(12)17(21)16(20)14(10)18/h6-7,10H,4-5,8-9H2,1-3H3/t10-/m0/s1;   InChIKey=GVKKJJOMQCNPGB-JTQLQIEISA-N;   SMILES=C=1C=C2C(CCCC2(C)C)=C3C1C4=C(C(C3=O)=O)[C@H](CO4)C
 xref: CAS:35825-57-1
 xref_mesh: MESH:C037886


show annotations for term's descendants           Sort by:
Cryptotanshinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions ISO cryptotanshinone inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid] CTD PMID:35101544 NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581 		JBrowse link
G Acat1 acetyl-CoA acetyltransferase 1 decreases expression ISO cryptotanshinone results in decreased expression of ACAT1 mRNA CTD PMID:38936533 NCBI chr 8:62,876,003...62,905,080
Ensembl chr 8:62,876,003...62,905,042 		JBrowse link
G Ache acetylcholinesterase multiple interactions ISO cryptotanshinone binds to and results in decreased activity of ACHE protein CTD PMID:20350537 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410 		JBrowse link
G Acta2 actin alpha 2, smooth muscle decreases expression
multiple interactions 		ISO cryptotanshinone results in decreased expression of ACTA2 mRNA; cryptotanshinone results in decreased expression of ACTA2 protein
cryptotanshinone inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; cryptotanshinone inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]
CPT1A protein inhibits the reaction [cryptotanshinone results in decreased expression of ACTA2 mRNA]; CPT1A protein inhibits the reaction [cryptotanshinone results in decreased expression of ACTA2 protein] 		CTD PMID:38936533 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO cryptotanshinone promotes the reaction [beta-Naphthoflavone results in increased expression of AHR mRNA] CTD PMID:21262253 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901 		JBrowse link
G Bche butyrylcholinesterase multiple interactions ISO cryptotanshinone binds to and results in decreased activity of BCHE protein CTD PMID:20350537 NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760 		JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
increases activity 		ISO cryptotanshinone results in increased cleavage of CASP3 protein
benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [cryptotanshinone results in increased cleavage of CASP3 protein]
cryptotanshinone results in increased activity of CASP3 protein 		CTD PMID:26564229 PMID:28600121 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp7 caspase 7 increases activity ISO cryptotanshinone results in increased activity of CASP7 protein CTD PMID:26564229 NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512 		JBrowse link
G Casp9 caspase 9 increases activity ISO cryptotanshinone results in increased activity of CASP9 protein CTD PMID:26564229 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO cryptotanshinone inhibits the reaction [Dinoprostone results in decreased expression of CDH1 protein] CTD PMID:30208247 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
decreases expression 		ISO CPT1A protein inhibits the reaction [cryptotanshinone results in decreased expression of COL1A1 mRNA]; CPT1A protein inhibits the reaction [cryptotanshinone results in decreased expression of COL1A1 protein]
cryptotanshinone inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein]; cryptotanshinone inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]
cryptotanshinone results in decreased expression of COL1A1 mRNA; cryptotanshinone results in decreased expression of COL1A1 protein 		CTD PMID:38936533 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions
decreases expression 		ISO CPT1A protein inhibits the reaction [cryptotanshinone results in decreased expression of ACTA2 mRNA]; CPT1A protein inhibits the reaction [cryptotanshinone results in decreased expression of ACTA2 protein]; CPT1A protein inhibits the reaction [cryptotanshinone results in decreased expression of COL1A1 mRNA]; CPT1A protein inhibits the reaction [cryptotanshinone results in decreased expression of COL1A1 protein]
cryptotanshinone results in decreased expression of CPT1A mRNA; cryptotanshinone results in decreased expression of CPT1A protein 		CTD PMID:38936533 NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:209,993,875...210,056,326 		JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B decreases expression ISO cryptotanshinone results in decreased expression of CPT1B mRNA CTD PMID:38936533 NCBI chr 7:122,370,974...122,380,473
Ensembl chr 7:122,370,444...122,380,036 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO cryptotanshinone inhibits the reaction [Dinoprostone results in increased expression of CTNNB1 protein] CTD PMID:30208247 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression 		ISO cryptotanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; cryptotanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; Dactinomycin inhibits the reaction [cryptotanshinone results in increased expression of CYP1A1 mRNA]; Resveratrol inhibits the reaction [cryptotanshinone results in increased expression of CYP1A1 mRNA]
cryptotanshinone results in increased expression of CYP1A1 mRNA; cryptotanshinone results in increased expression of CYP1A1 protein 		CTD PMID:21262253 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
multiple interactions 		ISO cryptotanshinone results in increased expression of CYP1A2 mRNA; cryptotanshinone results in increased expression of CYP1A2 protein
cryptotanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]; cryptotanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein]; Dactinomycin inhibits the reaction [cryptotanshinone results in increased expression of CYP1A2 mRNA]; Resveratrol inhibits the reaction [cryptotanshinone results in increased expression of CYP1A2 mRNA] 		CTD PMID:21262253 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO cryptotanshinone results in increased expression of CYP3A4 protein CTD PMID:18805405 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO cryptotanshinone inhibits the reaction [Dinoprostone results in increased expression of EGFR protein modified form] CTD PMID:30208247 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO cryptotanshinone inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein]; cryptotanshinone inhibits the reaction [Lithocholic Acid results in increased expression of GPT protein] CTD PMID:36804361 PMID:38936533 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO cryptotanshinone inhibits the reaction [Dinoprostone results in decreased expression of GSK3B protein] CTD PMID:30208247 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249 		JBrowse link
G Jak2 Janus kinase 2 decreases phosphorylation ISO cryptotanshinone results in decreased phosphorylation of JAK2 protein CTD PMID:38936533 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases expression 		ISO Acetylcysteine inhibits the reaction [cryptotanshinone results in increased expression of MAP1LC3B protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog promotes the reaction [cryptotanshinone results in increased expression of MAP1LC3B protein]; cryptotanshinone promotes the reaction [Chloroquine results in increased expression of MAP1LC3B protein] CTD PMID:28600121 NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions ISO cryptotanshinone inhibits the reaction [notoginsenoside R1 results in increased expression of MCL1 protein] CTD PMID:38316350 NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [cryptotanshinone results in increased degradation of and results in increased phosphorylation of NFKBIA protein]; Acetylcysteine inhibits the reaction [cryptotanshinone results in increased degradation of and results in increased phosphorylation of NFKBIA protein]; cryptotanshinone results in increased degradation of and results in increased phosphorylation of NFKBIA protein CTD PMID:28600121 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO cryptotanshinone results in increased activity of NR1I2 protein CTD PMID:18805405 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO cryptotanshinone results in increased cleavage of PARP1 protein CTD PMID:26564229 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Ptger2 prostaglandin E receptor 2 multiple interactions ISO cryptotanshinone inhibits the reaction [Dinoprostone results in increased expression of PTGER2 protein] CTD PMID:30208247 NCBI chr15:20,694,765...20,708,475
Ensembl chr15:20,696,013...20,708,950 		JBrowse link
G Ptger4 prostaglandin E receptor 4 multiple interactions ISO cryptotanshinone inhibits the reaction [Dinoprostone results in increased expression of PTGER4 protein] CTD PMID:30208247 NCBI chr 2:56,061,699...56,074,594
Ensembl chr 2:56,062,890...56,074,135 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 decreases activity ISO cryptotanshinone results in decreased activity of PTPN1 protein CTD PMID:29031618 NCBI chr 3:177,056,588...177,106,424
Ensembl chr 3:177,057,659...177,106,416 		JBrowse link
G Rarb retinoic acid receptor, beta increases expression ISO cryptotanshinone results in increased expression of RARB protein CTD PMID:38936533 NCBI chr15:10,837,252...11,482,037
Ensembl chr15:11,131,358...11,482,040 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
affects localization 		ISO 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [cryptotanshinone affects the localization of RELA protein]; Acetylcysteine inhibits the reaction [cryptotanshinone affects the localization of RELA protein]; cryptotanshinone inhibits the reaction [TNF protein affects the localization of RELA protein] CTD PMID:26564229 PMID:28600121 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Rxra retinoid X receptor alpha increases expression ISO cryptotanshinone results in increased expression of RXRA protein CTD PMID:38936533 NCBI chr 3:31,387,892...31,474,415
Ensembl chr 3:31,388,223...31,474,417 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
decreases expression 		ISO Chloroquine inhibits the reaction [cryptotanshinone results in decreased expression of SQSTM1 protein] CTD PMID:28600121 NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation
multiple interactions 		ISO cryptotanshinone results in decreased phosphorylation of STAT3 protein
cryptotanshinone results in decreased phosphorylation of and affects the localization of STAT3 protein
cryptotanshinone inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of STAT3 protein] 		CTD PMID:28578322 PMID:38936533 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO cryptotanshinone inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; cryptotanshinone inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein] CTD PMID:38936533 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO cryptotanshinone inhibits the reaction [TNF protein affects the localization of RELA protein] CTD PMID:26564229 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Top2a DNA topoisomerase II alpha decreases expression
multiple interactions 		ISO cryptotanshinone results in decreased expression of TOP2A mRNA
cryptotanshinone results in decreased expression of and results in decreased activity of TOP2A protein 		CTD PMID:28716507 NCBI chr10:84,441,954...84,473,093
Ensembl chr10:84,441,954...84,473,366 		JBrowse link
G Top2b DNA topoisomerase II beta decreases expression ISO cryptotanshinone results in decreased expression of TOP2B mRNA CTD PMID:28716507 NCBI chr15:11,482,089...11,542,464
Ensembl chr15:11,482,089...11,542,464 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      biological role 20818
        antimicrobial agent 18578
          antiviral agent 11455
            anticoronaviral agent 10071
              Cryptotanshinone 38
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    main group molecular entity 20781
                      s-block molecular entity 20574
                        hydrogen molecular entity 20558
                          hydrides 19693
                            organic hydride 19079
                              organic fundamental parent 19079
                                hydrocarbon 18731
                                  terpene 14163
                                    terpenoid 13875
                                      diterpenoid 13091
                                        abietane diterpenoid 425
                                          Cryptotanshinone 38
paths to the root