pyrazole - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	pyrazole	go back to main search page
Accession:	CHEBI:14973	browse the term
Definition:	A monocyclic heteroarene that is a five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 2.
Synonyms:	related_synonym:	Formula=C3H4N2; Pyrazol
	xref:	PMID:24816008; Wikipedia:Pyrazole
	cyclic_relationship:	is_conjugate_acid_of CHEBI:38596

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Genes (1601)

1H-pyrazole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alcohol dehydrogenase 1C (class I), gamma polypeptide

multiple interactions
decreases activity

pyrazole inhibits the reaction [ADH1 protein results in increased metabolism of Ethanol]
pyrazole results in decreased activity of ADH1 protein

PMID:7646056 PMID:15551062 PMID:16289176

NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892

G

alcohol dehydrogenase 4 (class II), pi polypeptide

decreases activity

pyrazole results in decreased activity of ADH4 protein

NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591

G

activator of Hsp90 ATPase activity 1

increases expression

pyrazole results in increased expression of AHSA1 mRNA

NCBI chr 6:106,913,296...106,921,347
Ensembl chr 6:106,913,530...106,921,345

G

AIF family member 3

decreases expression

pyrazole results in decreased expression of AIFM3 mRNA

NCBI chr11:83,504,859...83,523,630
Ensembl chr11:83,504,861...83,521,248

G

aldo-keto reductase family 1 member A1

multiple interactions

pyrazole inhibits the reaction [AKR1A1 protein results in increased reduction of muconaldehyde]

NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674

G

aldolase, fructose-bisphosphate C

decreases expression

pyrazole results in decreased expression of ALDOC mRNA

NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066

G

alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase

increases expression

pyrazole results in increased expression of ALKBH2 mRNA

NCBI chr12:42,494,187...42,500,929
Ensembl chr12:42,496,300...42,500,914

G

apurinic/apyrimidinic endodeoxyribonuclease 1

increases expression

pyrazole results in increased expression of APEX1 mRNA

NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785

G

anti-silencing function 1A histone chaperone

increases expression

pyrazole results in increased expression of ASF1A mRNA

NCBI chr20:32,893,962...32,908,808
Ensembl chr20:32,893,573...32,908,808

G

activating transcription factor 4

increases expression

pyrazole results in increased expression of ATF4 mRNA

NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446

G

activating transcription factor 5

increases expression

pyrazole results in increased expression of ATF5 mRNA

NCBI chr 1:95,295,602...95,299,755
Ensembl chr 1:95,295,610...95,299,707

G

activating transcription factor 6

increases expression

pyrazole results in increased expression of ATF6 mRNA

NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177

G

activating transcription factor 6 beta

increases expression

pyrazole results in increased expression of ATF6B mRNA

NCBI chr20:4,090,921...4,098,920
Ensembl chr20:4,090,921...4,098,894

G

BCL2-associated agonist of cell death

multiple interactions

[Ethanol co-treated with pyrazole co-treated with Carbon Tetrachloride] results in increased expression of BAD mRNA

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BAG cochaperone 3

increases expression

pyrazole results in increased expression of BAG3 mRNA

NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858

G

BCL2-antagonist/killer 1

multiple interactions

[Ethanol co-treated with pyrazole co-treated with Carbon Tetrachloride] results in increased expression of BAK1 mRNA

NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264

G

BCL2 associated X, apoptosis regulator

increases expression

pyrazole results in increased expression of BAX mRNA

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL10, immune signaling adaptor

increases expression

pyrazole results in increased expression of BCL10 mRNA

NCBI chr 2:234,840,880...234,850,520
Ensembl chr 2:234,840,858...234,850,523

G

BCL2, apoptosis regulator

decreases expression

pyrazole results in decreased expression of BCL2 mRNA

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

decreases expression

pyrazole results in decreased expression of BCL2L1 mRNA

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

Bcl2-like 11

increases expression

pyrazole results in increased expression of BCL2L11 mRNA

NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068

G

BCL3, transcription coactivator

increases expression

pyrazole results in increased expression of BCL3 mRNA

NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607

G

BH3 interacting domain death agonist

increases expression

pyrazole results in increased expression of BID mRNA

NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720

G

BCL2-interacting killer

multiple interactions

[Ethanol co-treated with pyrazole co-treated with Carbon Tetrachloride] results in increased expression of BIK mRNA

NCBI chr 7:114,672,277...114,691,296
Ensembl chr 7:114,672,277...114,691,296

G

biliverdin reductase A

multiple interactions

pyrazole results in increased expression of and results in increased activity of BLVRA protein

NCBI chr 3:114,340,778...114,366,048
Ensembl chr 3:114,340,838...114,366,033

G

Bcl2 modifying factor

decreases expression

pyrazole results in decreased expression of BMF mRNA

NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145

G

BCL2 interacting protein 3

decreases expression

pyrazole results in decreased expression of BNIP3 mRNA

NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359

G

BCL2 family apoptosis regulator BOK

decreases expression

pyrazole results in decreased expression of BOK mRNA

NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476

G

BTG anti-proliferation factor 2

increases expression

pyrazole results in increased expression of BTG2 mRNA

NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628

G

calreticulin 3

increases expression

pyrazole results in increased expression of CALR3 mRNA

NCBI chr16:17,396,064...17,423,166
Ensembl chr16:17,396,247...17,423,015

G

carbonic anhydrase 3

decreases expression

pyrazole results in decreased expression of CAR3 mRNA

NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280

G

caspase 7

decreases expression

pyrazole results in decreased expression of CASP7 mRNA

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

catalase

multiple interactions

pyrazole promotes the reaction [triptolide results in decreased activity of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

carbonyl reductase 3

increases expression

pyrazole results in increased expression of CBR3 mRNA

NCBI chr11:33,008,615...33,016,877
Ensembl chr11:33,008,615...33,016,875

G

cyclin D1

increases expression
decreases expression

pyrazole results in increased expression of CCND1 mRNA
pyrazole results in decreased expression of CCND1 protein

PMID:17945193 PMID:33737021

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

chaperonin containing TCP1 subunit 2

increases expression

pyrazole results in increased expression of CCT2 mRNA

NCBI chr 7:52,692,725...52,705,478
Ensembl chr 7:52,692,725...52,706,944

G

chaperonin containing TCP1 subunit 5

increases expression

pyrazole results in increased expression of CCT5 mRNA

NCBI chr 2:82,591,750...82,602,903
Ensembl chr 2:82,590,630...82,602,930

G

chaperonin containing TCP1 subunit 7

increases expression

pyrazole results in increased expression of CCT7 mRNA

NCBI chr 4:117,989,232...118,006,478
Ensembl chr 4:117,989,232...118,006,580

G

cyclin dependent kinase like 2

increases expression

pyrazole results in increased expression of CDKL2 mRNA

NCBI chr14:16,027,381...16,063,257
Ensembl chr14:16,028,363...16,063,252

G

cyclin-dependent kinase inhibitor 1A

increases expression

pyrazole results in increased expression of CDKN1A mRNA

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

CCAAT/enhancer binding protein gamma

increases expression

pyrazole results in increased expression of CEBPG mRNA

NCBI chr 1:87,683,060...87,692,772
Ensembl chr 1:87,684,019...87,694,569

G

cell death-inducing DFFA-like effector b

decreases expression

pyrazole results in decreased expression of CIDEB mRNA

NCBI chr15:29,252,208...29,256,482
Ensembl chr15:29,252,213...29,256,605

G

cell death-inducing DFFA-like effector c

increases expression

pyrazole results in increased expression of CIDEC mRNA

NCBI chr 4:146,569,288...146,582,173
Ensembl chr 4:146,569,289...146,582,173

G

crystallin, alpha B

increases expression

pyrazole results in increased expression of CRYAB mRNA

NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157

G

cytochrome P450, family 17, subfamily a, polypeptide 1

decreases expression

pyrazole results in decreased expression of CYP17A1 mRNA

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 2, subfamily a, polypeptide 3

increases expression

pyrazole results in increased expression of CYP2A3 mRNA

NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979

G

cytochrome P450, family 2, subfamily C, polypeptide 6

decreases expression

pyrazole results in decreased expression of CYP2C29 mRNA

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily d, polypeptide 4

decreases expression

pyrazole results in decreased expression of CYP2D22 mRNA

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 2, subfamily e, polypeptide 1

increases expression
increases activity
affects expression

pyrazole results in increased expression of CYP2E1 protein
pyrazole results in increased activity of CYP2E1 protein
pyrazole affects the expression of CYP2E1 protein

PMID:3113478 PMID:3782137 PMID:8074729 PMID:8734847 PMID:9698299 More...

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 2, subfamily f, polypeptide 4

decreases expression

pyrazole results in decreased expression of CYP2F2 mRNA

NCBI chr 1:82,416,107...82,429,897
Ensembl chr 1:82,416,130...82,429,896

G

cytochrome P450, family 2, subfamily j, polypeptide 4

multiple interactions

pyrazole results in increased expression of and results in increased activity of CYP2J4 protein; pyrazole results in increased stability of and results in increased expression of CYP2J4 mRNA

NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794

G

cytochrome P450, family 2, subfamily r, polypeptide 1

increases expression

pyrazole results in increased expression of CYP2R1 mRNA

NCBI chr 1:168,749,302...168,798,079
Ensembl chr 1:168,751,038...168,797,759

G

cytochrome P450, family 39, subfamily a, polypeptide 1

decreases expression

pyrazole results in decreased expression of CYP39A1 mRNA

NCBI chr 9:17,230,455...17,306,775
Ensembl chr 9:17,230,455...17,306,775

G

cytochrome P450, family 4, subfamily f, polypeptide 1

decreases expression

pyrazole results in decreased expression of CYP4F14 mRNA

NCBI chr 7:12,010,850...12,022,497
Ensembl chr 7:12,010,852...12,022,046

G

cytochrome P450, family 4, subfamily v, polypeptide 3

decreases expression

pyrazole results in decreased expression of CYP4V3 mRNA

NCBI chr16:46,917,929...46,958,735
Ensembl chr16:46,918,401...46,943,395

G

cytochrome P450, family 51

increases expression

pyrazole results in increased expression of CYP51 mRNA

NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
Ensembl chr 6:30,036,865...30,055,410

G

cytochrome P450 family 7 subfamily A member 1

decreases expression

pyrazole results in decreased expression of CYP7A1 mRNA

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

cytochrome P450 family 8 subfamily B member 1

decreases expression

pyrazole results in decreased expression of CYP8B1 mRNA

NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166

G

D-box binding PAR bZIP transcription factor

decreases expression

pyrazole results in decreased expression of DBP mRNA

NCBI chr 1:96,175,796...96,180,745
Ensembl chr 1:96,175,440...96,180,745

G

DNA-damage inducible transcript 3

increases expression

pyrazole results in increased expression of DDIT3 mRNA

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DNA-damage-inducible transcript 4-like

increases expression

pyrazole results in increased expression of DDIT4L mRNA

NCBI chr 2:226,128,273...226,131,044
Ensembl chr 2:226,128,276...226,131,375

G

derlin 1

increases expression

pyrazole results in increased expression of DERL1 mRNA

NCBI chr 7:89,404,413...89,427,095
Ensembl chr 7:89,404,417...89,427,145

G

derlin 3

increases expression

pyrazole results in increased expression of DERL3 mRNA

NCBI chr20:12,754,490...12,768,454
Ensembl chr20:12,763,543...12,767,027

G

DnaJ heat shock protein family (Hsp40) member A1

increases expression

pyrazole results in increased expression of DNAJA1 mRNA

NCBI chr 5:55,842,414...55,853,326
Ensembl chr 5:55,842,426...55,853,967

G

DnaJ heat shock protein family (Hsp40) member A4

increases expression

pyrazole results in increased expression of DNAJA4 mRNA

NCBI chr 8:55,085,246...55,102,715
Ensembl chr 8:55,085,464...55,101,207

G

DnaJ heat shock protein family (Hsp40) member B1

increases expression

pyrazole results in increased expression of DNAJB1 mRNA

NCBI chr19:24,522,731...24,526,419
Ensembl chr19:24,522,717...24,526,458

G

DnaJ heat shock protein family (Hsp40) member B11

increases expression

pyrazole results in increased expression of DNAJB11 mRNA

NCBI chr11:78,151,750...78,168,259
Ensembl chr11:78,150,429...78,180,407

G

DnaJ heat shock protein family (Hsp40) member B2

increases expression

pyrazole results in increased expression of DNAJB2 mRNA

NCBI chr 9:76,731,060...76,739,278
Ensembl chr 9:76,731,065...76,739,277

G

DnaJ heat shock protein family (Hsp40) member B6

increases expression

pyrazole results in increased expression of DNAJB6 mRNA

NCBI chr 4:5,452,683...5,556,679
Ensembl chr 4:5,452,683...5,556,659

G

DnaJ heat shock protein family (Hsp40) member B9

increases expression

pyrazole results in increased expression of DNAJB9 mRNA

NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063

G

DnaJ heat shock protein family (Hsp40) member C10

increases expression

pyrazole results in increased expression of DNAJC10 mRNA

NCBI chr 3:65,232,031...65,272,732
Ensembl chr 3:65,232,697...65,272,719

G

DnaJ heat shock protein family (Hsp40) member C12

increases expression

pyrazole results in increased expression of DNAJC12 mRNA

NCBI chr20:25,246,744...25,267,508
Ensembl chr20:25,223,144...25,267,521

G

DnaJ heat shock protein family (Hsp40) member C18

increases expression

pyrazole results in increased expression of DNAJC18 mRNA

NCBI chr18:27,269,350...27,303,453
Ensembl chr18:27,269,355...27,298,344

G

DnaJ heat shock protein family (Hsp40) member C2

increases expression

pyrazole results in increased expression of DNAJC2 mRNA

NCBI chr 4:13,270,239...13,297,438
Ensembl chr 4:13,270,191...13,297,431

G

dual specificity phosphatase 10

increases expression

pyrazole results in increased expression of DUSP10 mRNA

NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716

G

ER degradation enhancing alpha-mannosidase like protein 1

increases expression

pyrazole results in increased expression of EDEM1 mRNA

NCBI chr 4:141,797,631...141,829,717
Ensembl chr 4:141,797,701...141,829,717

G

epoxide hydrolase 1

increases expression

pyrazole results in increased expression of EPHX1 mRNA

NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235

G

ERCC excision repair 1, endonuclease non-catalytic subunit

increases expression

pyrazole results in increased expression of ERCC1 mRNA

NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963

G

endoplasmic reticulum to nucleus signaling 1

increases expression

pyrazole results in increased expression of ERN1 mRNA

NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029

G

endoplasmic reticulum oxidoreductase 1 alpha

increases expression

pyrazole results in increased expression of ERO1A mRNA

NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478

G

endoplasmic reticulum protein 44

increases expression

pyrazole results in increased expression of ERP44 mRNA

NCBI chr 5:62,516,550...62,610,762
Ensembl chr 5:62,516,551...62,610,761

G

estrogen receptor 1

affects binding

pyrazole analog binds to ESR1 protein

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

affects binding

pyrazole analog binds to ESR2 protein

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

FKBP prolyl isomerase 11

increases expression

pyrazole results in increased expression of FKBP11 mRNA

NCBI chr 7:129,871,870...129,877,760
Ensembl chr 7:129,871,870...129,875,303

G

FKBP prolyl isomerase 1A

increases expression

pyrazole results in increased expression of FKBP1A mRNA

NCBI chr 3:140,040,359...140,060,107
Ensembl chr 3:140,040,278...140,060,743

G

forkhead box O3

decreases expression

pyrazole results in decreased expression of FOXO3 mRNA

NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561

G

glucose-6-phosphatase catalytic subunit 1

decreases expression

pyrazole results in decreased expression of G6PC1 mRNA

NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804

G

glucose-6-phosphate dehydrogenase

multiple interactions

G6PDX affects the reaction [pyrazole results in increased expression of and results in increased activity of CYP2A5 protein]; G6PDX affects the reaction [pyrazole results in increased expression of CYP2A5 mRNA]; G6PDX affects the reaction [pyrazole results in increased expression of HSPA5 protein]

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

growth arrest and DNA-damage-inducible, alpha

increases expression

pyrazole results in increased expression of GADD45A mRNA

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

1,4-alpha-glucan branching enzyme 1

increases expression

pyrazole results in increased expression of GBE1 mRNA

NCBI chr11:8,734,806...9,000,226
Ensembl chr11:8,734,820...9,000,210

G

glucokinase

decreases expression

pyrazole results in decreased expression of GCK mRNA

NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995

G

glutamate-cysteine ligase, catalytic subunit

increases expression

pyrazole results in increased expression of GCLC mRNA

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutamic--pyruvic transaminase

multiple interactions

pyrazole promotes the reaction [triptolide results in increased activity of GPT protein]

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione peroxidase 2

increases expression

pyrazole results in increased expression of GPX2 mRNA

NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877

G

glutathione-disulfide reductase

increases expression

pyrazole results in increased expression of GSR mRNA

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione synthetase

increases expression

pyrazole results in increased expression of GSS mRNA

NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198

G

glutathione S-transferase, C-terminal domain containing

increases expression

pyrazole results in increased expression of GSTCD mRNA

NCBI chr 2:221,499,732...221,591,888
Ensembl chr 2:221,499,083...221,591,857

G

glutathione S-transferase kappa 1

decreases expression

pyrazole results in decreased expression of GSTK1 mRNA

NCBI chr 4:71,118,979...71,123,298
Ensembl chr 4:71,118,896...71,123,292

G

glutathione S-transferase mu 1

increases expression

pyrazole results in increased expression of GSTM1 mRNA; pyrazole results in increased expression of GSTM1 protein

PMID:14610226 PMID:17945193

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase mu 4

increases expression

pyrazole results in increased expression of GSTM4 mRNA

NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:195,680,004...195,685,323

G

glutathione S-transferase theta 1

decreases expression

pyrazole results in decreased expression of GSTT1 mRNA

NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585

G

glycogenin 1

increases expression

pyrazole results in increased expression of GYG1 mRNA

NCBI chr 2:102,611,888...102,653,916
Ensembl chr 2:102,598,496...102,653,797

G

glycogen synthase 2

decreases expression

pyrazole results in decreased expression of GYS2 mRNA

NCBI chr 4:175,365,054...175,406,228
Ensembl chr 4:175,365,054...175,406,228

G

H2A.X variant histone

increases expression

pyrazole results in increased expression of H2AX mRNA

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239

G

heme oxygenase 1

increases expression
multiple interactions

pyrazole results in increased expression of HMOX1 mRNA
pyrazole results in increased expression of and results in increased activity of HMOX1 protein

PMID:17945193 PMID:25478736

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heterogeneous nuclear ribonucleoprotein A1

multiple interactions
increases expression

pyrazole promotes the reaction [HNRNPA1 protein binds to CYP2A5 mRNA]
pyrazole results in increased expression of HNRNPA1 protein

NCBI chr 7:134,375,318...134,381,610
Ensembl chr 7:134,375,150...134,381,609

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

decreases expression

pyrazole results in decreased expression of HSD3B2 mRNA

NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3

decreases expression

pyrazole results in decreased expression of HSD3B3 mRNA

NCBI chr 2:186,138,044...186,144,024
Ensembl chr 2:186,138,044...186,144,033

G

heat shock protein 90 alpha family class A member 1

increases expression

pyrazole results in increased expression of HSP90AA1 mRNA

NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268

G

heat shock protein 90 alpha family class B member 1

increases expression

pyrazole results in increased expression of HSP90AB1 mRNA

NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488

G

heat shock protein 90 beta family member 1

increases expression

pyrazole results in increased expression of HSP90B1 mRNA

NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788

G

heat shock protein family A (Hsp70) member 13

increases expression

pyrazole results in increased expression of HSPA13 mRNA

NCBI chr11:14,375,669...14,389,853
Ensembl chr11:14,373,275...14,389,895

G

heat shock protein family A (Hsp70) member 1A

increases expression

pyrazole results in increased expression of HSPA1A mRNA

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 1B

increases expression

pyrazole results in increased expression of HSPA1B mRNA

NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240

G

heat shock protein family A (Hsp70) member 4

increases expression

pyrazole results in increased expression of HSPA4 mRNA

NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001

G

heat shock protein family A (Hsp70) member 4 like

increases expression

pyrazole results in increased expression of HSPA4L mRNA

NCBI chr 2:123,740,384...123,793,088
Ensembl chr 2:123,740,384...123,793,084

G

heat shock protein family A (Hsp70) member 5

multiple interactions
increases expression

G6PDX affects the reaction [pyrazole results in increased expression of HSPA5 protein]; Vitamin E inhibits the reaction [pyrazole results in increased expression of HSPA5 protein]
pyrazole results in increased expression of HSPA5 mRNA; pyrazole results in increased expression of HSPA5 protein

PMID:12499123 PMID:14610226 PMID:17945193 PMID:18068688

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family A (Hsp70) member 8

increases expression

pyrazole results in increased expression of HSPA8 mRNA

NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259

G

heat shock protein family A (Hsp70) member 9

increases expression

pyrazole results in increased expression of HSPA9 mRNA

NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292

G

heat shock protein family B (small) member 1

increases expression

pyrazole results in increased expression of HSPB1 mRNA

NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743

G

heat shock protein family B (small) member 8

increases expression

pyrazole results in increased expression of HSPB8 mRNA

NCBI chr12:40,176,405...40,205,002
Ensembl chr12:40,176,532...40,191,185

G

heat shock protein family E (Hsp10) member 1

increases expression

pyrazole results in increased expression of HSPE1 mRNA

NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089

G

heat shock protein family H (Hsp110) member 1

increases expression

pyrazole results in increased expression of HSPH1 mRNA

NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224

G

interleukin 1 beta

multiple interactions

pyrazole analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

pyrazole analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; pyrazole promotes the reaction [triptolide results in increased expression of IL6 mRNA]; pyrazole promotes the reaction [triptolide results in increased expression of IL6 protein]

PMID:33094891 PMID:34758665

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

DNA ligase 3

increases expression

pyrazole results in increased expression of LIG3 mRNA

NCBI chr10:67,717,808...67,741,141
Ensembl chr10:67,717,812...67,798,414

G

MCL1 apoptosis regulator, BCL2 family member

increases expression

pyrazole results in increased expression of MCL1 mRNA

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

marker of proliferation Ki-67

decreases expression

pyrazole results in decreased expression of MKI67 protein

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

NFE2 like bZIP transcription factor 2

affects localization

pyrazole affects the localization of NFE2L2 protein

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NFKB inhibitor alpha

multiple interactions

pyrazole analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nucleolar protein 3

increases expression

pyrazole results in increased expression of NOL3 mRNA

NCBI chr19:33,154,061...33,158,250
Ensembl chr19:33,154,062...33,158,250

G

nucleophosmin/nucleoplasmin, 3

increases expression

pyrazole results in increased expression of NPM3 mRNA

NCBI chr 1:244,595,638...244,597,623
Ensembl chr 1:244,595,644...244,597,591

G

NAD(P)H quinone dehydrogenase 1

increases expression

pyrazole results in increased expression of NQO1 mRNA

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear protein 1, transcriptional regulator

increases expression

pyrazole results in increased expression of NUPR1 mRNA

NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281

G

8-oxoguanine DNA glycosylase

increases expression

pyrazole results in increased expression of OGG1 mRNA

NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766

G

pro-apoptotic WT1 regulator

increases expression

pyrazole results in increased expression of PAWR mRNA

NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028

G

pyruvate carboxylase

decreases expression

pyrazole results in decreased expression of PCX mRNA

NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380

G

phosphoenolpyruvate carboxykinase 1

decreases expression

pyrazole results in decreased expression of PCK1 mRNA

NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191

G

protein disulfide isomerase family A, member 3

increases expression

pyrazole results in increased expression of PDIA3 mRNA

NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236

G

protein disulfide isomerase family A, member 4

increases expression

pyrazole results in increased expression of PDIA4 mRNA

NCBI chr 4:76,803,198...76,822,245
Ensembl chr 4:76,803,198...76,822,107

G

protein disulfide isomerase family A, member 6

increases expression

pyrazole results in increased expression of PDIA6 mRNA

NCBI chr 6:40,062,980...40,080,223
Ensembl chr 6:40,062,926...40,080,613

G

prefoldin subunit 4

increases expression

pyrazole results in increased expression of PFDN4 mRNA

NCBI chr 3:159,303,173...159,311,221
Ensembl chr 3:159,303,071...159,311,219

G

phosphofructokinase, liver type

decreases expression

pyrazole results in decreased expression of PFKL mRNA

NCBI chr20:10,664,285...10,686,324
Ensembl chr20:10,664,272...10,686,315

G

PGAM family member 5, mitochondrial serine/threonine protein phosphatase

increases expression

pyrazole results in increased expression of PGAM5 mRNA

NCBI chr12:46,409,324...46,416,410
Ensembl chr12:46,409,369...46,416,420

G

phosphoglycerate kinase 2

increases expression

pyrazole results in increased expression of PGK2 mRNA

NCBI chr 9:20,480,367...20,481,933
Ensembl chr 9:20,480,203...20,571,481

G

phosphoglucomutase 1

increases expression

pyrazole results in increased expression of PGM1 mRNA

NCBI chr 5:114,595,298...114,654,728
Ensembl chr 5:114,595,293...114,654,728

G

phosphoglucomutase 3

increases expression

pyrazole results in increased expression of PGM3 mRNA

NCBI chr 8:87,518,317...87,536,021
Ensembl chr 8:87,517,701...87,536,022

G

phosphomannomutase 1

increases expression

pyrazole results in increased expression of PMM1 mRNA

NCBI chr 7:113,466,632...113,477,004
Ensembl chr 7:113,466,632...113,477,022

G

proteasome maturation protein

increases expression

pyrazole results in increased expression of POMP mRNA

NCBI chr12:7,162,098...7,174,737
Ensembl chr12:7,160,714...7,174,715

G

peroxisome proliferator-activated receptor gamma

increases expression

pyrazole results in increased expression of PPARG mRNA

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

PPARG coactivator 1 alpha

decreases expression

pyrazole results in decreased expression of PPARGC1A mRNA

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

peptidylprolyl isomerase A

increases expression

pyrazole results in increased expression of PPIA mRNA

NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601

G

peptidylprolyl isomerase D

increases expression

pyrazole results in increased expression of PPID mRNA

NCBI chr 2:164,727,803...164,740,168
Ensembl chr 2:164,727,779...164,740,221

G

peroxiredoxin 2

decreases expression

pyrazole results in decreased expression of PRDX2 mRNA

NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194

G

pre-mRNA processing factor 19

increases expression

pyrazole results in increased expression of PRPF19 mRNA

NCBI chr 1:207,541,582...207,552,664
Ensembl chr 1:207,541,595...207,552,662

G

phosphoserine aminotransferase 1

increases expression

pyrazole results in increased expression of PSAT1 mRNA

NCBI chr 1:213,196,709...213,218,564
Ensembl chr 1:213,196,709...213,218,682

G

proteasome 20S subunit alpha 1

increases expression

pyrazole results in increased expression of PSMA1 mRNA

NCBI chr 1:168,442,421...168,453,440
Ensembl chr 1:168,440,936...168,453,472

G

proteasome 20S subunit alpha 2

increases expression

pyrazole results in increased expression of PSMA2 mRNA

NCBI chr17:50,554,536...50,564,923
Ensembl chr17:50,551,924...50,564,938

G

proteasome 20S subunit alpha 4

increases expression

pyrazole results in increased expression of PSMA4 mRNA

NCBI chr 8:55,340,431...55,347,893
Ensembl chr 8:55,340,386...55,347,890

G

proteasome 20S subunit alpha 5

increases expression

pyrazole results in increased expression of PSMA5 mRNA

NCBI chr 2:195,896,369...195,919,733
Ensembl chr 2:195,896,365...195,919,731

G

proteasome 20S subunit alpha 7

increases expression

pyrazole results in increased expression of PSMA7 mRNA

NCBI chr 3:167,137,279...167,143,626
Ensembl chr 3:167,137,263...167,143,672

G

proteasome 20S subunit beta 2

increases expression

pyrazole results in increased expression of PSMB2 mRNA

NCBI chr 5:138,970,564...139,002,715
Ensembl chr 5:138,970,533...139,021,137

G

proteasome 20S subunit beta 3

increases expression

pyrazole results in increased expression of PSMB3 mRNA

NCBI chr10:82,697,425...82,704,521
Ensembl chr10:82,697,425...82,704,521

G

proteasome 20S subunit beta 4

increases expression

pyrazole results in increased expression of PSMB4 mRNA

NCBI chr 2:182,442,757...182,445,532
Ensembl chr 2:182,442,756...182,445,746

G

proteasome 20S subunit beta 5

increases expression

pyrazole results in increased expression of PSMB5 mRNA

NCBI chr15:28,072,772...28,077,367
Ensembl chr15:28,072,781...28,077,440

G

proteasome 26S subunit, ATPase 2

increases expression

pyrazole results in increased expression of PSMC2 mRNA

NCBI chr 4:13,255,850...13,270,160
Ensembl chr 4:13,255,856...13,270,185

G

proteasome 26S subunit, ATPase 3

increases expression

pyrazole results in increased expression of PSMC3 mRNA

NCBI chr 3:77,031,825...77,037,207
Ensembl chr 3:77,031,825...77,043,358

G

proteasome 26S subunit, ATPase 4

increases expression

pyrazole results in increased expression of PSMC4 mRNA

NCBI chr 1:83,349,127...83,357,497
Ensembl chr 1:83,348,592...83,357,494

G

proteasome 26S subunit, ATPase 6

increases expression

pyrazole results in increased expression of PSMC6 mRNA

NCBI chr15:18,542,585...18,564,057
Ensembl chr15:18,542,563...18,564,055

G

proteasome 26S subunit, non-ATPase 11

increases expression

pyrazole results in increased expression of PSMD11 mRNA

NCBI chr10:65,433,853...65,479,774
Ensembl chr10:65,433,853...65,479,766

G

proteasome 26S subunit, non-ATPase 12

increases expression

pyrazole results in increased expression of PSMD12 mRNA

NCBI chr10:92,438,223...92,457,323
Ensembl chr10:92,438,298...92,457,287

G

proteasome 26S subunit, non-ATPase 14

increases expression

pyrazole results in increased expression of PSMD14 mRNA

NCBI chr 3:46,254,338...46,347,076
Ensembl chr 3:46,254,330...46,347,076

G

proteasome 26S subunit ubiquitin receptor, non-ATPase 2

increases expression

pyrazole results in increased expression of PSMD2 mRNA

NCBI chr11:80,248,364...80,258,991
Ensembl chr11:80,248,364...80,259,043

G

proteasome 26S subunit, non-ATPase 3

increases expression

pyrazole results in increased expression of PSMD3 mRNA

NCBI chr10:83,643,473...83,655,620
Ensembl chr10:83,643,647...83,655,618

G

proteasome 26S subunit ubiquitin receptor, non-ATPase 4

increases expression

pyrazole results in increased expression of PSMD4 mRNA

NCBI chr 2:182,598,934...182,608,250
Ensembl chr 2:182,598,934...182,608,194

G

proteasome 26S subunit, non-ATPase 5

increases expression

pyrazole results in increased expression of PSMD5 mRNA

NCBI chr 3:18,133,715...18,151,000
Ensembl chr 3:18,133,717...18,151,029

G

proteasome 26S subunit, non-ATPase 6

increases expression

pyrazole results in increased expression of PSMD6 mRNA

NCBI chr15:11,102,174...11,112,180
Ensembl chr15:11,102,180...11,205,620

G

proteasome 26S subunit, non-ATPase 7

increases expression

pyrazole results in increased expression of PSMD7 mRNA

NCBI chr19:35,494,317...35,501,605
Ensembl chr19:35,494,316...35,501,588

G

proteasome 26S subunit, non-ATPase 8

increases expression

pyrazole results in increased expression of PSMD8 mRNA

NCBI chr 1:84,474,377...84,481,209
Ensembl chr 1:84,474,378...84,481,209

G

proteasome activator subunit 3

increases expression

pyrazole results in increased expression of PSME3 mRNA

NCBI chr10:86,257,672...86,265,458
Ensembl chr10:86,257,668...86,333,804

G

phosphatase and tensin homolog

decreases expression

pyrazole results in decreased expression of PTEN mRNA

NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838

G

glycogen phosphorylase L

decreases expression

pyrazole results in decreased expression of PYGL mRNA

NCBI chr 6:88,697,598...88,740,260
Ensembl chr 6:88,697,593...88,740,310

G

quiescin sulfhydryl oxidase 2

increases expression

pyrazole results in increased expression of QSOX2 mRNA

NCBI chr 3:9,034,994...9,064,649
Ensembl chr 3:9,034,994...9,064,664

G

RAD1 checkpoint DNA exonuclease

increases expression

pyrazole results in increased expression of RAD1 mRNA

NCBI chr 2:59,461,597...59,469,707
Ensembl chr 2:59,461,607...59,469,689

G

RAD18 E3 ubiquitin protein ligase

increases expression

pyrazole results in increased expression of RAD18 mRNA

NCBI chr 4:145,735,654...145,821,102
Ensembl chr 4:145,735,654...145,821,069

G

RAD51 paralog B

increases expression

pyrazole results in increased expression of RAD51B mRNA

NCBI chr 6:98,096,525...98,640,988
Ensembl chr 6:98,098,868...98,640,979

G

RAD52 homolog, DNA repair protein

increases expression

pyrazole results in increased expression of RAD52 mRNA

NCBI chr 4:153,106,062...153,128,598
Ensembl chr 4:153,106,062...153,128,207

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

pyrazole promotes the reaction [triptolide results in increased phosphorylation of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

rhotekin

increases expression

pyrazole results in increased expression of RTKN mRNA

NCBI chr 4:115,640,813...115,657,952
Ensembl chr 4:115,640,774...115,657,952

G

serpin family A member 7

increases expression

pyrazole results in increased expression of SERPINA7 mRNA

NCBI chr X:102,663,242...102,722,319
Ensembl chr X:102,663,405...102,669,040

G

superoxide dismutase 2

decreases expression

pyrazole results in decreased expression of SOD2 mRNA

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

sphingosine kinase 2

decreases expression

pyrazole results in decreased expression of SPHK2 mRNA

NCBI chr 1:96,180,872...96,188,592
Ensembl chr 1:96,180,887...96,188,391

G

small proline-rich protein 1A

increases expression

pyrazole results in increased expression of SPRR1A mRNA

NCBI chr 2:178,055,096...178,057,012
Ensembl chr 2:178,055,096...178,057,063

G

sulfiredoxin 1

increases expression

pyrazole results in increased expression of SRXN1 mRNA

NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448

G

sulfotransferase family 1B member 1

decreases expression

pyrazole results in decreased expression of SULT1B1 mRNA

NCBI chr14:20,492,763...20,505,491
Ensembl chr14:20,492,708...20,505,483

G

t-complex 1

increases expression

pyrazole results in increased expression of TCP1 mRNA

NCBI chr 1:47,829,061...47,836,809
Ensembl chr 1:47,828,652...47,836,839

G

thymidine kinase 1

decreases expression

pyrazole results in decreased expression of TK1 mRNA

NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,031,521...103,046,920

G

tumor necrosis factor

multiple interactions

pyrazole analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; pyrazole promotes the reaction [triptolide results in increased expression of TNF mRNA]; pyrazole promotes the reaction [triptolide results in increased expression of TNF protein]

PMID:33094891 PMID:34758665

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF alpha induced protein 1

increases expression

pyrazole results in increased expression of TNFAIP1 mRNA

NCBI chr10:63,417,774...63,432,466
Ensembl chr10:63,417,775...63,432,466

G

TNF superfamily member 9

multiple interactions

[Ethanol co-treated with pyrazole co-treated with Carbon Tetrachloride] results in increased expression of TNFSF9 mRNA

NCBI chr 9:1,944,017...1,946,351
Ensembl chr 9:1,944,017...1,946,345

G

tumor protein p53

increases expression

pyrazole results in increased expression of TRP53 mRNA

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tumor protein p53 binding protein 1

increases expression

pyrazole results in increased expression of TRP53BP1 mRNA

NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822

G

tumor protein p53 inducible nuclear protein 1

increases expression

pyrazole results in increased expression of TRP53INP1 mRNA

NCBI chr 5:24,253,986...24,272,250
Ensembl chr 5:24,260,568...24,267,968

G

Tnf receptor-associated factor 2

multiple interactions

[Ethanol co-treated with pyrazole co-treated with Carbon Tetrachloride] results in decreased expression of TRAF2 mRNA

NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538

G

TRAF-interacting protein

multiple interactions

[Ethanol co-treated with pyrazole co-treated with Carbon Tetrachloride] results in increased expression of TRAIP mRNA

NCBI chr 8:108,641,860...108,661,640
Ensembl chr 8:108,641,852...108,661,638

G

thioredoxin-like 1

increases expression

pyrazole results in increased expression of TXNL1 mRNA

NCBI chr18:57,125,362...57,155,167
Ensembl chr18:57,125,369...57,165,266

G

thioredoxin reductase 1

increases expression

pyrazole results in increased expression of TXNRD1 mRNA

NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863

G

ubiquitin-like modifier activating enzyme 5

increases expression

pyrazole results in increased expression of UBA5 mRNA

NCBI chr 8:104,665,241...104,680,915
Ensembl chr 8:104,665,046...104,680,894

G

ubiquitin-associated protein 1

increases expression

pyrazole results in increased expression of UBAP1 mRNA

NCBI chr 5:56,520,722...56,561,153
Ensembl chr 5:56,520,743...56,561,152

G

ubiquitin-conjugating enzyme E2F (putative)

increases expression

pyrazole results in increased expression of UBE2F mRNA

NCBI chr 9:91,845,975...91,881,145
Ensembl chr 9:91,845,987...91,880,594

G

ubiquitin-conjugating enzyme E2I

increases expression

pyrazole results in increased expression of UBE2I mRNA

NCBI chr10:14,277,749...14,294,681
Ensembl chr10:69,701,618...69,702,443
Ensembl chr10:69,701,618...69,702,443

G

ubiquitin-conjugating enzyme E2L 3

increases expression

pyrazole results in increased expression of UBE2L3 mRNA

NCBI chr11:83,797,722...83,838,862
Ensembl chr11:83,797,722...83,838,862

G

ubiquitin conjugating enzyme E2 U

decreases expression

pyrazole results in decreased expression of UBE2U mRNA

NCBI chr 5:115,118,234...115,187,296
Ensembl chr 5:115,118,495...115,186,874

G

ubiquitination factor E4B

increases expression

pyrazole results in increased expression of UBE4B mRNA

NCBI chr 5:159,766,829...159,870,509
Ensembl chr 5:159,766,829...159,870,509

G

ubiquitin-like 4A

increases expression

pyrazole results in increased expression of UBL4A mRNA

NCBI chr X:152,151,242...152,154,094
Ensembl chr X:152,151,460...152,154,069

G

ubiquitin protein ligase E3 component n-recognin 2

decreases expression

pyrazole results in decreased expression of UBR2 mRNA

NCBI chr 9:13,982,427...14,062,315
Ensembl chr 9:13,982,329...14,062,139

G

ubiquitin C-terminal hydrolase L3

increases expression

pyrazole results in increased expression of UCHL3 mRNA

NCBI chr15:78,485,304...78,527,355
Ensembl chr15:78,485,315...78,527,355
Ensembl chr 3:78,485,315...78,527,355

G

ubiquitin recognition factor in ER associated degradation 1

increases expression

pyrazole results in increased expression of UFD1 mRNA

NCBI chr11:82,161,618...82,185,107
Ensembl chr11:82,161,619...82,185,087

G

ubiquitin-fold modifier 1

increases expression

pyrazole results in increased expression of UFM1 mRNA

NCBI chr 2:137,969,476...137,977,620
Ensembl chr 2:137,966,678...137,978,089
Ensembl chr 2:137,966,678...137,978,089

G

UDP glucuronosyltransferase family 2 member B7

increases expression

pyrazole results in increased expression of UGT2B34 mRNA

NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604

G

uracil-DNA glycosylase

increases expression

pyrazole results in increased expression of UNG mRNA

NCBI chr12:42,485,276...42,494,217
Ensembl chr12:42,485,276...42,494,206

G

uridine phosphorylase 2

decreases expression

pyrazole results in decreased expression of UPP2 mRNA

NCBI chr 3:43,273,048...43,317,417
Ensembl chr 3:43,273,048...43,317,417

G

ubiquitin specific peptidase 14

increases expression

pyrazole results in increased expression of USP14 mRNA

NCBI chr18:1,018,111...1,057,727
Ensembl chr18:1,019,400...1,057,519

G

ubiquitin specific peptidase 2

decreases expression

pyrazole results in decreased expression of USP2 mRNA

NCBI chr 8:44,411,457...44,439,668
Ensembl chr 8:44,411,607...44,438,331

G

ubiquitin specific peptidase 22

increases expression

pyrazole results in increased expression of USP22 mRNA

NCBI chr10:45,828,619...45,855,468
Ensembl chr10:45,828,622...45,855,497

G

valosin-containing protein

increases expression

pyrazole results in increased expression of VCP mRNA

NCBI chr 5:57,210,167...57,229,571
Ensembl chr 5:57,210,168...57,229,571

G

X-ray repair cross complementing 4

increases expression

pyrazole results in increased expression of XRCC4 mRNA

NCBI chr 2:20,948,464...21,197,705
Ensembl chr 2:20,951,200...21,197,808

5-methyl-pyrazole-3-carboxylic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

D-amino-acid oxidase

decreases activity

5-methylpyrazole-3-carboxylic acid results in decreased activity of DAO protein

NCBI chr12:42,592,342...42,613,046
Ensembl chr12:42,592,343...42,612,741

fenpyroximate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 1

increases expression

fenpyroximate results in increased expression of ABCA1 mRNA

NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170

G

acetylcholinesterase

decreases activity

fenpyroximate results in decreased activity of ACHE protein

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

aldo-keto reductase family 1 member B1

decreases expression

fenpyroximate results in decreased expression of AKR1B1 mRNA

NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157

G

aldo-keto reductase family 7, member A2

decreases expression

fenpyroximate results in decreased expression of AKR7A2 mRNA

NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909

G

AKT serine/threonine kinase 1

decreases expression

fenpyroximate results in decreased expression of AKT1 mRNA

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

aldehyde dehydrogenase 9 family, member A1

decreases expression

fenpyroximate results in decreased expression of ALDH9A1 mRNA

NCBI chr13:79,505,738...79,522,539
Ensembl chr13:79,505,695...79,540,568

G

APC membrane recruitment protein 1

decreases expression

fenpyroximate results in decreased expression of AMER1 mRNA

NCBI chr X:60,300,595...60,316,480
Ensembl chr X:60,295,751...60,316,440

G

anoctamin 10

decreases expression

fenpyroximate results in decreased expression of ANO10 mRNA

NCBI chr 8:121,841,664...121,960,739
Ensembl chr 8:121,841,665...121,962,670

G

adaptor related protein complex 3 subunit mu 1

decreases expression

fenpyroximate results in decreased expression of AP3M1 mRNA

NCBI chr15:3,246,616...3,264,846
Ensembl chr15:3,246,926...3,264,844

G

apurinic/apyrimidinic endodeoxyribonuclease 1

increases expression

fenpyroximate results in increased expression of APEX1 mRNA

NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785

G

arginase 1

decreases expression

fenpyroximate results in decreased expression of ARG1 mRNA

NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422

G

Rho GTPase activating protein 9

increases expression

fenpyroximate results in increased expression of ARHGAP9 mRNA

NCBI chr 7:63,148,573...63,157,025
Ensembl chr 7:63,148,900...63,157,524

G

arrestin domain containing 4

decreases expression

fenpyroximate results in decreased expression of ARRDC4 mRNA

NCBI chr 1:122,369,355...122,383,351
Ensembl chr 1:122,369,360...122,383,290

G

asparagine synthetase (glutamine-hydrolyzing)

increases expression

fenpyroximate results in increased expression of ASNS mRNA

NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423

G

argininosuccinate synthase 1

increases expression

fenpyroximate results in increased expression of ASS1 mRNA

NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903

G

activating transcription factor 4

increases expression

fenpyroximate results in increased expression of ATF4 mRNA

NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446

G

activating transcription factor 5

increases expression

fenpyroximate results in increased expression of ATF5 mRNA

NCBI chr 1:95,295,602...95,299,755
Ensembl chr 1:95,295,610...95,299,707

G

ATM interactor

decreases expression

fenpyroximate results in decreased expression of ATMIN mRNA

NCBI chr19:44,996,506...45,013,606
Ensembl chr19:44,996,356...45,013,605

G

ATP synthase F1 subunit beta

decreases expression

fenpyroximate results in decreased expression of ATP5F1B mRNA

NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273

G

ATP synthase F1 subunit gamma

decreases expression

fenpyroximate results in decreased expression of ATP5F1C mRNA

NCBI chr17:68,423,927...68,446,169
Ensembl chr17:68,423,909...68,608,367

G

ATPase H+ transporting V1 subunit B2

decreases expression

fenpyroximate results in decreased expression of ATP6V1B2 mRNA

NCBI chr16:20,617,515...20,641,651
Ensembl chr16:20,617,518...20,641,745

G

aurora kinase A

increases expression

fenpyroximate results in increased expression of AURKA mRNA

NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390

G

beta-2 microglobulin

increases expression

fenpyroximate results in increased expression of B2M mRNA

NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766

G

Beta-1,3-galactosyltransferase 6

decreases expression

fenpyroximate results in decreased expression of B3GALT6 mRNA

NCBI chr 5:166,584,202...166,586,338
Ensembl chr 5:166,584,202...166,586,338

G

BCL2 associated X, apoptosis regulator

increases expression

fenpyroximate results in increased expression of BAX mRNA

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression

fenpyroximate results in decreased expression of BCL2 mRNA

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 13

decreases expression

fenpyroximate results in decreased expression of BCL2L13 mRNA

NCBI chr 4:154,056,116...154,112,890
Ensembl chr 4:154,056,127...154,108,985

G

baculoviral IAP repeat-containing 5

increases expression

fenpyroximate results in increased expression of BIRC5 mRNA

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

Bcl2 modifying factor

decreases expression

fenpyroximate results in decreased expression of BMF mRNA

NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145

G

biphenyl hydrolase like

decreases expression

fenpyroximate results in decreased expression of BPHL mRNA

NCBI chr17:30,800,939...30,837,277
Ensembl chr17:30,799,629...30,837,288

G

basic leucine zipper and W2 domains 1

decreases expression

fenpyroximate results in decreased expression of BZW1 mRNA

NCBI chr 9:59,930,672...59,944,468
Ensembl chr 9:59,930,744...59,944,430

G

C2 calcium-dependent domain containing 5

decreases expression

fenpyroximate results in decreased expression of C2CD5 mRNA

NCBI chr 4:175,969,544...176,055,597
Ensembl chr 4:175,969,545...176,055,558

G

calnexin

increases expression

fenpyroximate results in increased expression of CANX mRNA

NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821

G

cysteinyl-tRNA synthetase 1

increases expression

fenpyroximate results in increased expression of CARS1 mRNA

NCBI chr 1:198,753,689...198,796,016
Ensembl chr 1:198,753,691...198,795,941

G

caspase 3

increases activity
multiple interactions

fenpyroximate results in increased activity of CASP3 protein
Acetylcysteine inhibits the reaction [fenpyroximate results in increased activity of CASP3 protein]

PMID:35580743 PMID:36933581

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

increases activity

fenpyroximate results in increased activity of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

increases activity
affects activity

fenpyroximate results in increased activity of CAT protein
fenpyroximate affects the activity of CAT protein

PMID:35580743 PMID:36933581

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

carbonyl reductase 1

decreases expression

fenpyroximate results in decreased expression of CBR1 mRNA

NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393

G

chromobox 4

increases expression

fenpyroximate results in increased expression of CBX4 mRNA

NCBI chr10:104,337,140...104,343,210
Ensembl chr10:104,336,876...104,356,706

G

cyclin B1

increases expression

fenpyroximate results in increased expression of CCNB1 mRNA

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin B2

increases expression

fenpyroximate results in increased expression of CCNB2 mRNA

NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874

G

CD24 molecule

decreases expression

fenpyroximate results in decreased expression of CD24 mRNA

NCBI chr20:47,074,353...47,079,662
Ensembl chr20:47,073,512...47,079,662

G

cadherin 10

decreases expression

fenpyroximate results in decreased expression of CDH10 mRNA

NCBI chr 2:68,628,623...68,850,995
Ensembl chr 2:68,628,780...68,850,995

G

cadherin 2

decreases expression

fenpyroximate results in decreased expression of CDH2 mRNA

NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167

G

cyclin-dependent kinase 1

increases expression

fenpyroximate results in increased expression of CDK1 mRNA

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

cyclin-dependent kinase 5 regulatory subunit 1

decreases expression

fenpyroximate results in decreased expression of CDK5R1 mRNA

NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456

G

cyclin-dependent kinase 6

increases expression

fenpyroximate results in increased expression of CDK6 mRNA

NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634

G

cyclin-dependent kinase inhibitor 3

increases expression

fenpyroximate results in increased expression of CDKN3 mRNA

NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945

G

CCAAT/enhancer binding protein beta

increases expression

fenpyroximate results in increased expression of CEBPB mRNA

NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473

G

carboxyl ester lipase

decreases expression

fenpyroximate results in decreased expression of CEL mRNA

NCBI chr 3:11,883,532...11,891,035
Ensembl chr 3:11,883,532...11,891,035

G

cofilin 2

decreases expression

fenpyroximate results in decreased expression of CFL2 mRNA

NCBI chr 6:72,355,664...72,359,709
Ensembl chr 6:72,355,664...72,359,674

G

ChaC glutathione-specific gamma-glutamylcyclotransferase 1

increases expression

fenpyroximate results in increased expression of CHAC1 mRNA

NCBI chr 3:106,342,302...106,345,526
Ensembl chr 3:106,342,302...106,345,526

G

checkpoint kinase 1

increases expression

fenpyroximate results in increased expression of CHEK1 mRNA

NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009

G

choline kinase alpha

increases expression

fenpyroximate results in increased expression of CHKA mRNA

NCBI chr 1:201,076,804...201,125,517
Ensembl chr 1:201,076,860...201,125,516

G

CDC28 protein kinase regulatory subunit 1B

increases expression

fenpyroximate results in increased expression of CKS1B mRNA

NCBI chr 2:174,833,025...174,837,614
Ensembl chr 2:174,833,050...174,837,636

G

CDC28 protein kinase regulatory subunit 2

increases expression

fenpyroximate results in increased expression of CKS2 mRNA

NCBI chr17:13,570,611...13,575,770

G

chloride intracellular channel 4

increases expression

fenpyroximate results in increased expression of CLIC4 mRNA

NCBI chr 5:147,453,702...147,513,455
Ensembl chr 5:147,453,712...147,513,452

G

canopy FGF signaling regulator 3

increases expression

fenpyroximate results in increased expression of CNPY3 mRNA

NCBI chr 9:14,233,478...14,247,847
Ensembl chr 9:14,233,428...14,247,831

G

contactin 1

increases expression

fenpyroximate results in increased expression of CNTN1 mRNA

NCBI chr 7:123,263,146...123,560,896
Ensembl chr 7:123,372,792...123,558,541

G

cytochrome c oxidase assembly factor 6

increases expression

fenpyroximate results in increased expression of COA6 mRNA

NCBI chr19:54,395,746...54,398,348
Ensembl chr19:54,395,742...54,399,407

G

collagen type XVI alpha 1 chain

increases expression

fenpyroximate results in increased expression of COL16A1 mRNA

NCBI chr 5:142,388,376...142,442,825
Ensembl chr 5:142,388,426...142,442,825

G

COP9 signalosome subunit 5

decreases expression

fenpyroximate results in decreased expression of COPS5 mRNA

NCBI chr 5:9,192,233...9,210,498
Ensembl chr 5:9,192,100...9,210,731

G

CREB3 regulatory factor

increases expression

fenpyroximate results in increased expression of CREBRF mRNA

NCBI chr10:16,399,170...16,479,650
Ensembl chr10:16,404,596...16,461,999

G

cellular repressor of E1A-stimulated genes 1

increases expression

fenpyroximate results in increased expression of CREG1 mRNA

NCBI chr13:78,019,814...78,032,310
Ensembl chr13:78,019,843...78,032,308

G

cysteine-rich with EGF-like domains 2

increases expression

fenpyroximate results in increased expression of CRELD2 mRNA

NCBI chr 7:119,909,626...119,916,556
Ensembl chr 7:119,909,633...119,916,543

G

cartilage associated protein

increases expression

fenpyroximate results in increased expression of CRTAP mRNA

NCBI chr 8:114,047,929...114,067,636
Ensembl chr 8:114,047,933...114,067,631

G

catenin alpha-like 1

increases expression

fenpyroximate results in increased expression of CTNNAL1 mRNA

NCBI chr 5:71,514,340...71,569,431
Ensembl chr 5:71,514,340...71,569,431

G

catenin delta 1

decreases expression

fenpyroximate results in decreased expression of CTNND1 mRNA

NCBI chr 3:69,683,328...69,734,550
Ensembl chr 3:69,683,313...69,734,516

G

CTP synthase 1

decreases expression

fenpyroximate results in decreased expression of CTPS1 mRNA

NCBI chr 5:134,125,022...134,154,155
Ensembl chr 5:134,125,025...134,154,180

G

cortactin

decreases expression

fenpyroximate results in decreased expression of CTTN mRNA

NCBI chr 1:199,599,710...199,635,254
Ensembl chr 1:199,599,710...199,635,164

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression

fenpyroximate results in increased expression of CYP1A1 mRNA

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 2, subfamily C, polypeptide 6

decreases expression

fenpyroximate results in decreased expression of CYP2C19 protein

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 3, subfamily a, polypeptide 9

increases expression

fenpyroximate results in increased expression of CYP3A5 mRNA

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

cytochrome P450 family 7 subfamily A member 1

decreases expression

fenpyroximate results in decreased expression of CYP7A1 mRNA; fenpyroximate results in decreased expression of CYP7A1 protein

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

dishevelled associated activator of morphogenesis 1

decreases expression

fenpyroximate results in decreased expression of DAAM1 mRNA

NCBI chr 6:90,389,544...90,550,114
Ensembl chr 6:90,389,688...90,550,114

G

death-domain associated protein

decreases expression

fenpyroximate results in decreased expression of DAXX mRNA

NCBI chr20:4,970,090...4,976,145
Ensembl chr20:4,970,092...4,975,843

G

deoxycytidine kinase

decreases expression

fenpyroximate results in decreased expression of DCK mRNA

NCBI chr14:19,305,218...19,326,247
Ensembl chr14:19,305,218...19,326,247

G

dopa decarboxylase

decreases expression

fenpyroximate results in decreased expression of DDC mRNA

NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208

G

DNA-damage inducible transcript 3

increases expression

fenpyroximate results in increased expression of DDIT3 mRNA

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DEP domain containing 1B

increases expression

fenpyroximate results in increased expression of DEPDC1B mRNA

NCBI chr 2:39,891,163...39,963,779
Ensembl chr 2:39,891,481...39,963,779

G

DNA fragmentation factor subunit beta

decreases expression

fenpyroximate results in decreased expression of DFFB mRNA

NCBI chr 5:164,522,446...164,534,733
Ensembl chr 5:164,522,463...164,534,628

G

DLG associated protein 5

increases expression

fenpyroximate results in increased expression of DLGAP5 mRNA

NCBI chr15:20,633,964...20,664,569
Ensembl chr15:20,633,966...20,664,518

G

DnaJ heat shock protein family (Hsp40) member B14

increases expression

fenpyroximate results in increased expression of DNAJB14 mRNA

NCBI chr 2:226,358,988...226,409,461
Ensembl chr 2:226,358,996...226,402,490

G

deoxynucleotidyltransferase, terminal, interacting protein 2

decreases expression

fenpyroximate results in decreased expression of DNTTIP2 mRNA

NCBI chr 2:210,374,321...210,386,366
Ensembl chr 2:210,374,289...210,385,581

G

dopamine receptor D2

decreases expression

fenpyroximate results in decreased expression of DRD2 mRNA

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

G

dual specificity phosphatase 4

increases expression

fenpyroximate results in increased expression of DUSP4 mRNA

NCBI chr16:57,376,659...57,398,161
Ensembl chr16:57,377,229...57,398,138

G

eukaryotic translation elongation factor 1 gamma

decreases expression

fenpyroximate results in decreased expression of EEF1G mRNA

NCBI chr 1:205,860,713...205,871,319
Ensembl chr 1:205,860,698...205,872,382

G

early growth response 1

increases expression

fenpyroximate results in increased expression of EGR1 mRNA

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

eukaryotic translation initiation factor 2 subunit beta

increases expression

fenpyroximate results in increased expression of EIF2S2 mRNA

NCBI chr 3:143,374,652...143,395,460
Ensembl chr 3:143,373,686...143,395,432

G

eukaryotic translation initiation factor 4E binding protein 1

increases expression

fenpyroximate results in increased expression of EIF4EBP1 mRNA

NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984

G

ELMO domain containing 1

decreases expression

fenpyroximate results in decreased expression of ELMOD1 mRNA

NCBI chr 8:54,298,363...54,355,348
Ensembl chr 8:54,298,363...54,355,140

G

E1A binding protein p300

decreases expression

fenpyroximate results in decreased expression of EP300 mRNA

NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088

G

Eph receptor B2

decreases expression

fenpyroximate results in decreased expression of EPHB2 mRNA

NCBI chr 5:148,889,574...149,077,027
Ensembl chr 5:148,897,246...149,077,059

G

endoplasmic reticulum oxidoreductase 1 alpha

increases expression

fenpyroximate results in increased expression of ERO1A mRNA

NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478

G

endoplasmic reticulum oxidoreductase 1 beta

increases expression

fenpyroximate results in increased expression of ERO1B mRNA

NCBI chr17:85,861,086...86,003,244
Ensembl chr17:85,929,618...86,003,398

G

estrogen receptor 2

multiple interactions

fenpyroximate inhibits the reaction [Estradiol results in increased activity of ESR2 protein]

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

estrogen related receptor, alpha

multiple interactions

fenpyroximate inhibits the reaction [PPARGC1A protein results in increased activity of ESRRA protein]; fenpyroximate inhibits the reaction [XCT790 results in decreased activity of ESRRA protein]

NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268

G

exosome component 4

decreases expression

fenpyroximate results in decreased expression of EXOSC4 mRNA

NCBI chr 7:108,047,831...108,050,573
Ensembl chr 7:108,047,831...108,050,573

G

exosome component 8

increases expression

fenpyroximate results in increased expression of EXOSC8 mRNA

NCBI chr 2:138,930,405...138,937,009
Ensembl chr 2:138,930,405...138,936,928

G

family with sequence similarity 72, member A

increases expression

fenpyroximate results in increased expression of FAM72A mRNA

NCBI chr13:42,967,701...42,979,083
Ensembl chr13:42,967,578...42,984,208

G

fibrillarin

increases expression

fenpyroximate results in increased expression of FBL mRNA

NCBI chr 1:83,469,832...83,478,932
Ensembl chr 1:83,469,832...83,478,932

G

F-box protein 7

decreases expression

fenpyroximate results in decreased expression of FBXO7 mRNA

NCBI chr 7:17,809,224...17,837,549
Ensembl chr 7:17,809,231...17,837,530

G

fibroblast growth factor 2

increases expression

fenpyroximate results in increased expression of FGF2 mRNA

NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221

G

ferritin heavy chain 1

increases expression

fenpyroximate results in increased expression of FTH1 mRNA

NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424

G

ferritin light chain 1

increases expression

fenpyroximate results in increased expression of FTL mRNA

NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725
Ensembl chr 2:95,936,387...95,939,725

G

glucose-6-phosphatase catalytic subunit 1

decreases expression

fenpyroximate results in decreased expression of G6PC1 mRNA

NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804

G

glucose-6-phosphate dehydrogenase

decreases expression

fenpyroximate results in decreased expression of G6PD mRNA

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

growth arrest and DNA-damage-inducible, beta

increases expression

fenpyroximate results in increased expression of GADD45B mRNA

NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046

G

growth arrest and DNA-damage-inducible, gamma

increases expression

fenpyroximate results in increased expression of GADD45G mRNA

NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610

G

growth associated protein 43

decreases expression

fenpyroximate results in decreased expression of GAP43 mRNA

NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045

G

glutamate cysteine ligase, modifier subunit

increases expression

fenpyroximate results in increased expression of GCLM mRNA

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

growth differentiation factor 15

increases expression

fenpyroximate results in increased expression of GDF15 mRNA

NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055

G

GDP-L-fucose synthase

increases expression

fenpyroximate results in increased expression of GFUS mRNA

NCBI chr 7:107,612,087...107,617,005
Ensembl chr 7:107,612,094...107,616,948

G

glycine decarboxylase

decreases expression

fenpyroximate results in decreased expression of GLDC mRNA

NCBI chr 1:227,883,249...227,962,119
Ensembl chr 1:227,883,249...227,962,097

G

GLI family zinc finger 3

decreases expression

fenpyroximate results in decreased expression of GLI3 mRNA

NCBI chr17:49,438,567...49,709,712
Ensembl chr17:49,438,567...49,709,712

G

glutaredoxin

decreases expression

fenpyroximate results in decreased expression of GLRX mRNA

NCBI chr 2:5,341,873...5,351,686
Ensembl chr 2:5,341,885...5,351,680

G

G protein subunit alpha i2

decreases expression

fenpyroximate results in decreased expression of GNAI2 mRNA

NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979

G

growth factor receptor bound protein 10

increases expression

fenpyroximate results in increased expression of GRB10 mRNA

NCBI chr14:86,495,051...86,602,800
Ensembl chr14:86,495,054...86,602,806

G

glutamate metabotropic receptor 4

decreases expression

fenpyroximate results in decreased expression of GRM4 mRNA

NCBI chr20:5,484,172...5,572,821
Ensembl chr20:5,481,124...5,572,821

G

glutathione S-transferase mu 2

decreases expression

fenpyroximate results in decreased expression of GSTM2 mRNA

NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961

G

H1.2 linker histone, cluster member

increases expression

fenpyroximate results in increased expression of H1-2 mRNA

NCBI chr17:41,391,106...41,392,597
Ensembl chr17:41,388,477...41,392,635

G

H2B clustered histone 3

increases expression

fenpyroximate results in increased expression of H2BC3 mRNA

NCBI chr17:41,380,056...41,380,686

G

H2B clustered histone 9

increases expression

fenpyroximate results in increased expression of H2BC9 mRNA

NCBI chr17:42,470,593...42,478,590

G

HUWE1 associated protein modifying stress responses

increases expression

fenpyroximate results in increased expression of HAPSTR1 mRNA

NCBI chr10:6,746,037...6,774,992
Ensembl chr10:6,746,048...6,774,992

G

hematopoietic cell signal transducer

increases expression

fenpyroximate results in increased expression of HCST mRNA

NCBI chr 1:85,676,976...85,679,083
Ensembl chr 1:85,676,979...85,679,012

G

histone deacetylase 2

decreases expression

fenpyroximate results in decreased expression of HDAC2 mRNA

NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609

G

homocysteine inducible ER protein with ubiquitin like domain 1

increases expression

fenpyroximate results in increased expression of HERPUD1 mRNA

NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424

G

hes family bHLH transcription factor 1

increases expression

fenpyroximate results in increased expression of HES1 mRNA

NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192

G

histone cluster 1 H2A family member F

increases expression

fenpyroximate results in increased expression of H2AC8 mRNA

NCBI chr17:41,379,404...41,379,796
Ensembl chr17:41,379,404...41,379,796

G

histone cluster 1 H2A family member H

increases expression

fenpyroximate results in increased expression of H2AC11 mRNA

NCBI chr17:41,384,521...41,385,018

G

histone cluster 1 H2A family like 1

increases expression

fenpyroximate results in increased expression of H2AC6 mRNA

NCBI chr17:42,707,954...42,708,420

G

histone cluster 1 H2B family member D

increases expression

fenpyroximate results in increased expression of H2BC5 mRNA

NCBI chr17:42,792,887...42,793,268

G

heme oxygenase 1

increases expression

fenpyroximate results in increased expression of HMOX1 mRNA

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heterogeneous nuclear ribonucleoprotein M

decreases expression

fenpyroximate results in decreased expression of HNRNPM mRNA

NCBI chr 7:14,438,703...14,476,781
Ensembl chr 7:14,438,688...14,476,762

G

heat shock protein 90 beta family member 1

increases expression

fenpyroximate results in increased expression of HSP90B1 mRNA

NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788

G

heat shock protein family A (Hsp70) member 1B

increases expression

fenpyroximate results in increased expression of HSPA1B mRNA

NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240

G

heat shock protein family E (Hsp10) member 1

increases expression

fenpyroximate results in increased expression of HSPE1 mRNA

NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089

G

HIV-1 Tat specific factor 1

decreases expression

fenpyroximate results in decreased expression of HTATSF1 mRNA

NCBI chr X:134,935,426...134,949,607
Ensembl chr X:134,935,426...134,949,607

G

inhibitor of DNA binding 1

decreases expression

fenpyroximate results in decreased expression of ID1 mRNA

NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419

G

inhibitor of DNA binding 2

increases expression

fenpyroximate results in increased expression of ID2 mRNA

NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400

G

interferon-related developmental regulator 1

increases expression

fenpyroximate results in increased expression of IFRD1 mRNA

NCBI chr 6:57,269,395...57,317,833
Ensembl chr 6:57,269,384...57,288,990

G

insulin-like growth factor 1 receptor

decreases expression

fenpyroximate results in decreased expression of IGF1R mRNA

NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777

G

insulin-like growth factor binding protein 2

decreases expression

fenpyroximate results in decreased expression of IGFBP2 mRNA

NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937

G

internexin neuronal intermediate filament protein, alpha

decreases expression

fenpyroximate results in decreased expression of INA mRNA

NCBI chr 1:245,896,775...245,908,330
Ensembl chr 1:245,896,775...245,908,330

G

importin 5

increases expression

fenpyroximate results in increased expression of IPO5 mRNA

NCBI chr15:97,990,755...98,041,074
Ensembl chr15:98,005,299...98,041,126

G

inositol 1,4,5-trisphosphate receptor, type 2

decreases expression

fenpyroximate results in decreased expression of ITPR2 mRNA

NCBI chr 4:179,028,594...179,434,657
Ensembl chr 4:179,027,281...179,404,164

G

jumonji domain containing 6, arginine demethylase and lysine hydroxylase

increases expression

fenpyroximate results in increased expression of JMJD6 mRNA

NCBI chr10:102,041,131...102,047,182
Ensembl chr10:102,041,120...102,047,182

G

lysine demethylase 3A

decreases expression

fenpyroximate results in decreased expression of KDM3A mRNA

NCBI chr 4:103,630,907...103,675,073
Ensembl chr 4:103,630,908...103,675,073

G

lysine demethylase 5B

decreases expression

fenpyroximate results in decreased expression of KDM5B mRNA

NCBI chr13:46,001,589...46,073,868
Ensembl chr13:46,002,542...46,073,872

G

kinesin family member 15

increases expression

fenpyroximate results in increased expression of KIF15 mRNA

NCBI chr 8:122,601,888...122,672,750
Ensembl chr 8:122,601,897...122,672,750

G

kinesin family member 20A

increases expression

fenpyroximate results in increased expression of KIF20A mRNA

NCBI chr18:26,230,294...26,238,780
Ensembl chr18:26,230,230...26,238,780

G

kinesin family member 5C

decreases expression

fenpyroximate results in decreased expression of KIF5C mRNA

NCBI chr 3:34,032,082...34,185,597
Ensembl chr 3:34,032,105...34,182,413

G

kelch-like family member 24

increases expression

fenpyroximate results in increased expression of KLHL24 mRNA

NCBI chr11:80,843,621...80,877,649
Ensembl chr11:80,846,755...80,877,636

G

kinetochore scaffold 1

increases expression

fenpyroximate results in increased expression of KNL1 mRNA

NCBI chr 3:106,029,627...106,091,915
Ensembl chr 3:106,029,661...106,091,915

G

kynurenine aminotransferase 3

decreases expression

fenpyroximate results in decreased expression of KYAT3 mRNA

NCBI chr 2:231,701,881...231,747,462
Ensembl chr 2:231,701,963...231,747,227

G

lysyl oxidase-like 1

decreases expression

fenpyroximate results in decreased expression of LOXL1 mRNA

NCBI chr 8:58,691,763...58,716,365
Ensembl chr 8:58,692,593...58,716,356

G

leucine rich repeat containing 41

decreases expression

fenpyroximate results in decreased expression of LRRC41 mRNA

NCBI chr 5:129,554,547...129,575,450
Ensembl chr 5:129,554,547...129,575,449

G

mesencephalic astrocyte-derived neurotrophic factor

increases expression

fenpyroximate results in increased expression of MANF mRNA

NCBI chr 8:107,500,856...107,551,595
Ensembl chr 8:107,548,352...107,551,438

G

microtubule-associated protein 1B

decreases expression

fenpyroximate results in decreased expression of MAP1B mRNA

NCBI chr 2:30,817,261...30,910,458
Ensembl chr 2:30,817,261...30,910,317

G

microtubule-associated protein 6

decreases expression

fenpyroximate results in decreased expression of MAP6 mRNA

NCBI chr 1:153,568,020...153,634,415
Ensembl chr 1:153,568,368...153,634,414

G

minichromosome maintenance complex component 7

increases expression

fenpyroximate results in increased expression of MCM7 mRNA

NCBI chr12:17,042,207...17,049,470
Ensembl chr12:17,042,212...17,050,063

G

midkine

increases expression

fenpyroximate results in increased expression of MDK mRNA

NCBI chr 3:77,901,134...77,903,997
Ensembl chr 3:77,901,158...77,903,130

G

malic enzyme 1

increases expression

fenpyroximate results in increased expression of ME1 mRNA

NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304

G

marker of proliferation Ki-67

increases expression

fenpyroximate results in increased expression of MKI67 mRNA

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

MLLT11, transcription factor 7 cofactor

decreases expression

fenpyroximate results in decreased expression of MLLT11 mRNA

NCBI chr 2:182,795,790...182,804,960
Ensembl chr 2:182,795,790...182,797,199

G

MNAT1 component of CDK activating kinase

decreases expression

fenpyroximate results in decreased expression of MNAT1 mRNA

NCBI chr 6:91,814,703...91,971,945
Ensembl chr 6:91,814,749...91,970,744

G

MORN repeat containing 2

decreases expression

fenpyroximate results in decreased expression of MORN2 mRNA

NCBI chr 6:14,718,799...14,725,281

G

musashi RNA-binding protein 2

decreases expression

fenpyroximate results in decreased expression of MSI2 mRNA

NCBI chr10:73,143,760...73,510,566
Ensembl chr10:73,147,380...73,510,157

G

metastasis associated 1

decreases expression

fenpyroximate results in decreased expression of MTA1 mRNA

NCBI chr 6:132,178,608...132,217,641
Ensembl chr 6:132,178,853...132,217,641

G

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase

increases expression

fenpyroximate results in increased expression of MTHFD2 mRNA

NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608

G

neuron navigator 1

decreases expression

fenpyroximate results in decreased expression of NAV1 mRNA

NCBI chr13:46,866,972...47,119,368
Ensembl chr13:46,873,689...47,126,449

G

neurocan

decreases expression

fenpyroximate results in decreased expression of NCAN mRNA

NCBI chr16:19,301,969...19,328,436
Ensembl chr16:19,301,969...19,328,436

G

NADH:ubiquinone oxidoreductase subunit A1

increases expression

fenpyroximate results in increased expression of NDUFA1 mRNA

NCBI chr X:116,424,223...116,427,875
Ensembl chr X:116,424,223...116,428,633

G

NIMA-related kinase 2

increases expression

fenpyroximate results in increased expression of NEK2 mRNA

NCBI chr13:103,405,818...103,419,063
Ensembl chr13:103,405,819...103,419,051

G

nuclear factor of activated T-cells 3

decreases expression

fenpyroximate results in decreased expression of NFATC3 mRNA

NCBI chr19:33,960,643...34,035,150
Ensembl chr19:33,960,852...34,035,150

G

NFE2 like bZIP transcription factor 2

increases activity

fenpyroximate results in increased activity of NFE2L2 protein

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor, interleukin 3 regulated

decreases expression

fenpyroximate results in decreased expression of NFIL3 mRNA

NCBI chr17:12,280,499...12,295,728
Ensembl chr17:12,280,484...12,295,858

G

NFKB inhibitor beta

decreases expression

fenpyroximate results in decreased expression of NFKBIB mRNA

NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862

G

nitrilase 1

decreases expression

fenpyroximate results in decreased expression of NIT1 mRNA

NCBI chr13:83,769,888...83,773,324
Ensembl chr13:83,765,941...83,773,332

G

nicotinamide nucleotide adenylyltransferase 3

decreases response to substance

NMNAT3 protein results in decreased susceptibility to fenpyroximate

NCBI chr 8:98,892,168...99,003,912
Ensembl chr 8:98,873,398...99,020,645

G

nitric oxide synthase 3

increases expression

fenpyroximate results in increased expression of NOS3 mRNA

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

notch receptor 3

decreases expression

fenpyroximate results in decreased expression of NOTCH3 mRNA

NCBI chr 7:11,132,984...11,184,025
Ensembl chr 7:11,133,706...11,184,025

G

NAD(P)H quinone dehydrogenase 1

increases expression

fenpyroximate results in increased expression of NQO1 mRNA

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 2, group F, member 1

decreases expression

fenpyroximate results in decreased expression of NR2F1 mRNA

NCBI chr 2:8,040,375...8,050,123
Ensembl chr 2:8,040,377...8,050,123

G

nuclear receptor subfamily 3, group C, member 1

increases expression

fenpyroximate results in increased expression of NR3C1 mRNA

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

nuclear receptor subfamily 5, group A, member 1

decreases expression

fenpyroximate results in decreased expression of NR5A1 mRNA

NCBI chr 3:22,464,786...22,486,328
Ensembl chr 3:22,465,502...22,486,328

G

neuronal cell adhesion molecule

decreases expression

fenpyroximate results in decreased expression of NRCAM mRNA

NCBI chr 6:61,402,813...61,698,536
Ensembl chr 6:61,329,863...61,702,992

G

neurexin 1

decreases expression

fenpyroximate results in decreased expression of NRXN1 mRNA

NCBI chr 6:3,177,788...4,323,848
Ensembl chr 6:3,177,897...4,322,710

G

neurotrophic receptor tyrosine kinase 1

decreases expression

fenpyroximate results in decreased expression of NTRK1 mRNA

NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770

G

ornithine decarboxylase antizyme 1

increases expression

fenpyroximate results in increased expression of OAZ1 mRNA

NCBI chr 7:8,883,855...8,886,315
Ensembl chr 7:8,883,851...8,886,310

G

olfactomedin-like 2B

decreases expression

fenpyroximate results in decreased expression of OLFML2B mRNA

NCBI chr13:82,869,414...82,906,607
Ensembl chr13:82,869,433...82,906,607

G

oligosaccharyltransferase complex non-catalytic subunit

increases expression

fenpyroximate results in increased expression of OSTC mRNA

NCBI chr 2:219,250,549...219,266,076
Ensembl chr 2:219,236,952...219,266,107

G

platelet-activating factor acetylhydrolase 1b, catalytic subunit 3

decreases expression

fenpyroximate results in decreased expression of PAFAH1B3 mRNA

NCBI chr 1:80,881,263...80,883,789
Ensembl chr 1:80,881,309...80,883,893

G

Parkinsonism associated deglycase

decreases response to substance

PARK7 protein results in decreased susceptibility to fenpyroximate

NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970

G

poly (ADP-ribose) polymerase 2

increases expression

fenpyroximate results in increased expression of PARP2 mRNA

NCBI chr15:24,034,069...24,044,340
Ensembl chr15:24,034,106...24,044,338

G

protein disulfide isomerase family A, member 6

increases expression

fenpyroximate results in increased expression of PDIA6 mRNA

NCBI chr 6:40,062,980...40,080,223
Ensembl chr 6:40,062,926...40,080,613

G

phosphatidylethanolamine binding protein 1

decreases expression

fenpyroximate results in decreased expression of PEBP1 mRNA

NCBI chr12:39,302,864...39,307,064
Ensembl chr12:39,302,840...39,307,862

G

paternally expressed 10

decreases expression

fenpyroximate results in decreased expression of PEG10 mRNA

NCBI chr 4:32,842,441...32,855,639
Ensembl chr 4:32,848,493...32,852,621

G

phosphofructokinase, platelet

increases expression

fenpyroximate results in increased expression of PFKP mRNA

NCBI chr17:63,729,743...63,794,026
Ensembl chr17:63,729,780...63,794,018

G

phosphoglucomutase 3

increases expression

fenpyroximate results in increased expression of PGM3 mRNA

NCBI chr 8:87,518,317...87,536,021
Ensembl chr 8:87,517,701...87,536,022

G

progesterone receptor

multiple interactions

fenpyroximate inhibits the reaction [Promegestone results in increased activity of PGR protein]

NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344

G

phosphoglycerate dehydrogenase

increases expression

fenpyroximate results in increased expression of PHGDH mRNA

NCBI chr 2:185,906,962...185,936,054
Ensembl chr 2:185,906,966...185,935,944

G

pleckstrin homology-like domain, family A, member 1

decreases expression

fenpyroximate results in decreased expression of PHLDA1 mRNA

NCBI chr 7:46,967,433...46,969,637
Ensembl chr 7:46,967,409...46,969,861

G

phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta

decreases expression

fenpyroximate results in decreased expression of PIK3C2B mRNA

NCBI chr13:44,494,673...44,555,663
Ensembl chr13:44,495,050...44,555,612

G

PTEN induced kinase 1

decreases expression

fenpyroximate results in decreased expression of PINK1 mRNA

NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635

G

phosphatidylinositol-5-phosphate 4-kinase type 2 beta

decreases expression

fenpyroximate results in decreased expression of PIP4K2B mRNA

NCBI chr10:82,706,016...82,734,938
Ensembl chr10:82,701,098...82,734,938

G

phosphatidylinositol transfer protein, alpha

decreases expression

fenpyroximate results in decreased expression of PITPNA mRNA

NCBI chr10:60,430,712...60,473,564
Ensembl chr10:60,430,748...60,471,342

G

perilipin 2

increases expression

fenpyroximate results in increased expression of PLIN2 mRNA

NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319

G

DNA polymerase epsilon 3, accessory subunit

increases expression

fenpyroximate results in increased expression of POLE3 mRNA

NCBI chr 5:75,973,941...75,977,175
Ensembl chr 5:75,974,717...75,977,231
Ensembl chr 7:75,974,717...75,977,231

G

PPARG coactivator 1 alpha

multiple interactions

fenpyroximate inhibits the reaction [PPARGC1A protein results in increased activity of ESRRA protein]

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

protein phosphatase 2 scaffold subunit A alpha

decreases expression

fenpyroximate results in decreased expression of PPP2R1A mRNA

NCBI chr 1:60,540,223...60,559,467
Ensembl chr 1:60,540,194...60,560,129

G

protein kinase AMP-activated non-catalytic subunit gamma 1

decreases expression

fenpyroximate results in decreased expression of PRKAG1 mRNA

NCBI chr 7:129,963,105...129,980,532
Ensembl chr 7:129,963,105...129,980,561

G

protein kinase cAMP-dependent type I regulatory subunit alpha

decreases expression

fenpyroximate results in decreased expression of PRKAR1A mRNA

NCBI chr10:94,621,042...94,639,534
Ensembl chr10:94,620,039...94,639,041

G

parkin RBR E3 ubiquitin protein ligase

decreases expression

fenpyroximate results in decreased expression of PRKN mRNA

NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555

G

proline rich 11

increases expression

fenpyroximate results in increased expression of PRR11 mRNA

NCBI chr10:71,898,858...71,943,325
Ensembl chr10:71,901,202...71,921,012

G

phosphoserine aminotransferase 1

increases expression

fenpyroximate results in increased expression of PSAT1 mRNA

NCBI chr 1:213,196,709...213,218,564
Ensembl chr 1:213,196,709...213,218,682

G

proteasome 20S subunit alpha 1

increases expression

fenpyroximate results in increased expression of PSMA1 mRNA

NCBI chr 1:168,442,421...168,453,440
Ensembl chr 1:168,440,936...168,453,472

G

protein tyrosine kinase 2 beta

decreases expression

fenpyroximate results in decreased expression of PTK2B mRNA

NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282

G

receptor interacting serine/threonine kinase 1

decreases expression

fenpyroximate results in decreased expression of RIPK1 mRNA

NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824

G

ring finger protein 4

increases expression

fenpyroximate results in increased expression of RNF4 mRNA

NCBI chr14:76,401,292...76,423,270
Ensembl chr14:76,401,299...76,422,566

G

RNA binding protein with serine rich domain 1

decreases expression

fenpyroximate results in decreased expression of RNPS1 mRNA

NCBI chr10:13,445,516...13,455,858
Ensembl chr10:13,445,653...13,455,858

G

replication protein A3

increases expression

fenpyroximate results in increased expression of RPA3 mRNA

NCBI chr 4:36,304,649...36,307,755
Ensembl chr 4:36,304,651...36,307,709

G

ribosomal protein L11

increases expression

fenpyroximate results in increased expression of RPL11 mRNA

NCBI chr 5:148,274,060...148,277,708
Ensembl chr 5:148,274,069...148,277,599

G

ribosomal protein L17

increases expression

fenpyroximate results in increased expression of RPL17 mRNA

NCBI chr18:68,581,141...68,584,253
Ensembl chr18:68,581,098...68,584,253
Ensembl chr 3:68,581,098...68,584,253

G

ribosomal protein L27

increases expression

fenpyroximate results in increased expression of RPL27 mRNA

NCBI chr10:86,375,511...86,379,210
Ensembl chr10:86,375,454...86,379,193

G

ribosomal protein L28

increases expression

fenpyroximate results in increased expression of RPL28 mRNA

NCBI chr 1:69,052,148...69,054,735
Ensembl chr 1:69,053,203...69,055,032

G

ribosomal protein L32

increases expression

fenpyroximate results in increased expression of RPL32 mRNA

NCBI chr 4:148,864,048...148,867,612
Ensembl chr 4:148,864,044...148,867,612
Ensembl chr 3:148,864,044...148,867,612

G

ribosomal protein L36

increases expression

fenpyroximate results in increased expression of RPL36 mRNA

NCBI chr 9:1,441,986...1,447,397
Ensembl chr 6:98,809,534...98,809,897
Ensembl chr 5:98,809,534...98,809,897

G

ribosomal protein L36A like 1

increases expression

fenpyroximate results in increased expression of RPL36AL mRNA

NCBI chr 6:87,654,808...87,656,202
Ensembl chr X:97,766,179...97,768,892
Ensembl chr10:97,766,179...97,768,892
Ensembl chr20:97,766,179...97,768,892

G

ribosomal protein L9

increases expression

fenpyroximate results in increased expression of RPL9 mRNA

NCBI chr14:42,893,945...42,897,140
Ensembl chr14:42,893,942...42,897,136
Ensembl chr 3:42,893,942...42,897,136
Ensembl chr 1:42,893,942...42,897,136

G

ribosomal protein S13

increases expression

fenpyroximate results in increased expression of RPS13 mRNA

NCBI chr 1:170,572,925...170,575,355
Ensembl chr 1:170,572,921...170,575,355
Ensembl chr 3:170,572,921...170,575,355

G

ribosomal protein S18

increases expression

fenpyroximate results in increased expression of RPS18 mRNA

NCBI chr20:4,931,427...4,935,538
Ensembl chr20:4,931,768...4,938,315

G

ribosomal protein S2

increases expression

fenpyroximate results in increased expression of RPS2 mRNA

NCBI chr10:13,747,316...13,749,165
Ensembl chr10:13,747,301...13,749,163

G

ribosomal protein s25

increases expression

fenpyroximate results in increased expression of RPS25 mRNA

NCBI chr 8:44,733,623...44,735,999
Ensembl chr 8:44,733,029...44,737,271
Ensembl chr 8:44,733,029...44,737,271

G

ribosomal protein S27a

increases expression

fenpyroximate results in increased expression of RPS27A mRNA

NCBI chr14:103,285,734...103,288,011
Ensembl chr14:103,285,734...103,288,011
Ensembl chr 5:103,285,734...103,288,011
Ensembl chr 5:103,285,734...103,288,011

G

ribosomal protein S3

increases expression

fenpyroximate results in increased expression of RPS3 mRNA

NCBI chr 1:153,778,363...153,783,663
Ensembl chr 1:153,777,472...153,783,680

G

ribosomal protein S5

increases expression

fenpyroximate results in increased expression of RPS5 mRNA

NCBI chr 1:73,538,776...73,543,073
Ensembl chr 1:73,538,776...73,543,073

G

ribosomal protein S7

increases expression

fenpyroximate results in increased expression of RPS7 mRNA

NCBI chr 6:45,266,200...45,271,064
Ensembl chr 6:45,223,980...45,271,145
Ensembl chr 5:45,223,980...45,271,145

G

ribosomal L24 domain containing 1

increases expression

fenpyroximate results in increased expression of RSL24D1 mRNA

NCBI chr 8:73,852,991...73,861,996
Ensembl chr 8:73,852,996...73,862,001

G

S100 calcium binding protein A13

increases expression

fenpyroximate results in increased expression of S100A13 mRNA

NCBI chr 2:175,999,439...176,005,933

G

S100 calcium-binding protein A4

increases expression

fenpyroximate results in increased expression of S100A4 mRNA

NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254

G

SATB homeobox 1

decreases expression

fenpyroximate results in decreased expression of SATB1 mRNA

NCBI chr 9:4,677,817...4,773,061
Ensembl chr 9:4,680,920...4,753,251

G

selenoprotein S

increases expression

fenpyroximate results in increased expression of SELENOS mRNA

NCBI chr 1:119,659,779...119,669,546
Ensembl chr 1:119,659,751...119,669,833

G

semaphorin 4B

decreases expression

fenpyroximate results in decreased expression of SEMA4B mRNA

NCBI chr 1:134,136,646...134,177,777
Ensembl chr 1:134,149,536...134,177,775

G

semaphorin 6D

decreases expression

fenpyroximate results in decreased expression of SEMA6D mRNA

NCBI chr 3:111,883,415...111,941,100
Ensembl chr 3:111,883,872...111,941,094

G

septin 10

increases expression

fenpyroximate results in increased expression of SEPTIN10 mRNA

NCBI chr20:27,101,764...27,194,997
Ensembl chr20:27,101,752...27,194,780

G

SERTA domain containing 1

increases expression

fenpyroximate results in increased expression of SERTAD1 mRNA

NCBI chr 1:82,775,692...82,778,961
Ensembl chr 1:82,775,252...82,779,091

G

sestrin 2

increases expression

fenpyroximate results in increased expression of SESN2 mRNA

NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260

G

SHC binding and spindle associated 1

increases expression

fenpyroximate results in increased expression of SHCBP1 mRNA

NCBI chr16:84,672,277...84,703,843
Ensembl chr16:84,672,321...84,703,844

G

solute carrier family 17 member 6

decreases expression

fenpyroximate results in decreased expression of SLC17A6 mRNA

NCBI chr 1:101,212,489...101,252,543
Ensembl chr 1:101,212,489...101,252,542

G

solute carrier family 35, member A5

decreases expression

fenpyroximate results in decreased expression of SLC35A5 mRNA

NCBI chr11:55,653,376...55,674,476
Ensembl chr11:55,653,394...55,674,473

G

solute carrier family 38, member 1

increases expression

fenpyroximate results in increased expression of SLC38A1 mRNA

NCBI chr 7:127,733,230...127,802,541
Ensembl chr 7:127,738,226...127,802,218

G

solute carrier family 3 member 2

increases expression

fenpyroximate results in increased expression of SLC3A2 mRNA

NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931

G

solute carrier family 7 member 5

increases expression

fenpyroximate results in increased expression of SLC7A5 mRNA

NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823

G

structural maintenance of chromosomes 3

increases expression

fenpyroximate results in increased expression of SMC3 mRNA

NCBI chr 1:252,601,422...252,644,522
Ensembl chr 1:252,601,753...252,644,522

G

survival motor neuron domain containing 1

decreases expression

fenpyroximate results in decreased expression of SMNDC1 mRNA

NCBI chr 1:252,389,675...252,400,749
Ensembl chr 1:252,389,673...252,401,616

G

snail family transcriptional repressor 2

increases expression

fenpyroximate results in increased expression of SNAI2 mRNA

NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200

G

synuclein alpha

increases response to substance

SNCA protein results in increased susceptibility to fenpyroximate

NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262

G

small nuclear ribonucleoprotein D3 polypeptide

increases expression

fenpyroximate results in increased expression of SNRPD3 mRNA

NCBI chr20:13,130,112...13,145,947
Ensembl chr20:13,130,119...13,145,978

G

suppressor of cytokine signaling 2

decreases expression

fenpyroximate results in decreased expression of SOCS2 mRNA

NCBI chr 7:30,006,360...30,045,161
Ensembl chr 7:30,008,578...30,043,548

G

sperm associated antigen 5

increases expression

fenpyroximate results in increased expression of SPAG5 mRNA

NCBI chr10:63,198,717...63,216,746
Ensembl chr10:63,198,768...63,216,745

G

SPC25 component of NDC80 kinetochore complex

increases expression

fenpyroximate results in increased expression of SPC25 mRNA

NCBI chr 3:53,930,013...53,988,940
Ensembl chr 3:53,975,704...53,988,959

G

SAM pointed domain containing ets transcription factor

decreases expression

fenpyroximate results in decreased expression of SPDEF mRNA

NCBI chr20:5,771,440...5,785,893
Ensembl chr20:5,771,441...5,785,893

G

serine and arginine rich splicing factor 10

increases expression

fenpyroximate results in increased expression of SRSF10 mRNA

NCBI chr 5:148,088,759...148,102,964
Ensembl chr 5:148,088,823...148,101,768

G

serine/threonine kinase 25

decreases expression

fenpyroximate results in decreased expression of STK25 mRNA

NCBI chr 9:94,161,834...94,174,095
Ensembl chr 9:94,161,836...94,174,244

G

synaptotagmin-like 1

increases expression

fenpyroximate results in increased expression of SYTL1 mRNA

NCBI chr 5:145,452,524...145,462,940
Ensembl chr 5:145,422,669...145,462,940

G

transforming, acidic coiled-coil containing protein 3

increases expression

fenpyroximate results in increased expression of TACC3 mRNA

NCBI chr14:77,051,209...77,065,343
Ensembl chr14:77,051,215...77,065,219

G

transcription factor 4

decreases expression

fenpyroximate results in decreased expression of TCF4 mRNA

NCBI chr18:62,941,739...63,288,126
Ensembl chr18:62,943,782...63,284,425

G

transcription factor Dp-1

decreases expression

fenpyroximate results in decreased expression of TFDP1 mRNA

NCBI chr16:76,162,040...76,200,871
Ensembl chr16:76,162,043...76,200,817

G

transforming growth factor, beta 3

decreases expression

fenpyroximate results in decreased expression of TGFB3 mRNA

NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564

G

thyroid hormone receptor alpha

increases activity

fenpyroximate results in increased activity of THRA protein

NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936

G

tousled-like kinase 2

decreases expression

fenpyroximate results in decreased expression of TLK2 mRNA

NCBI chr10:90,154,449...90,248,562
Ensembl chr10:90,156,813...90,248,561

G

transmembrane 9 superfamily member 3

decreases expression

fenpyroximate results in decreased expression of TM9SF3 mRNA

NCBI chr 1:240,032,060...240,085,125
Ensembl chr 1:240,035,003...240,084,776

G

transmembrane protein 185A

decreases expression

fenpyroximate results in decreased expression of TMEM185A mRNA

NCBI chr X:149,143,026...149,167,757
Ensembl chr X:149,143,031...149,167,757

G

tenascin C

decreases expression

fenpyroximate results in decreased expression of TNC mRNA

NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624

G

DNA topoisomerase II alpha

increases expression

fenpyroximate results in increased expression of TOP2A mRNA

NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874

G

tumor protein p53

increases expression

fenpyroximate results in increased expression of TP53 mRNA

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

TPX2, microtubule nucleation factor

increases expression

fenpyroximate results in increased expression of TPX2 mRNA

NCBI chr 3:141,318,428...141,360,684
Ensembl chr 3:141,318,455...141,360,468

G

tribbles pseudokinase 3

increases expression

fenpyroximate results in increased expression of TRIB3 mRNA

NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497

G

tripartite motif-containing 13

decreases expression

fenpyroximate results in decreased expression of TRIM13 mRNA

NCBI chr15:35,733,548...35,772,676
Ensembl chr15:35,734,107...35,772,677

G

transient receptor potential cation channel, subfamily V, member 1

decreases expression

fenpyroximate results in decreased expression of TRPV1 mRNA

NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513

G

TSC22 domain family, member 3

increases expression

fenpyroximate results in increased expression of TSC22D3 mRNA

NCBI chr X:104,217,898...104,277,886
Ensembl chr X:104,217,925...104,276,861

G

tumor susceptibility 101

decreases expression

fenpyroximate results in decreased expression of TSG101 mRNA

NCBI chr 1:97,412,689...97,442,589
Ensembl chr 1:97,410,848...97,442,554

G

tetraspanin 3

decreases expression

fenpyroximate results in decreased expression of TSPAN3 mRNA

NCBI chr 8:56,546,067...56,569,815
Ensembl chr 8:56,546,069...56,569,880

G

thiosulfate sulfurtransferase

decreases expression

fenpyroximate results in decreased expression of TST mRNA

NCBI chr 7:109,948,061...109,955,378
Ensembl chr 7:109,948,062...109,957,216

G

tubulin, beta 2B class IIb

decreases expression

fenpyroximate results in decreased expression of TUBB2B mRNA

NCBI chr17:30,747,734...30,750,781
Ensembl chr17:30,747,734...30,750,638

G

thioredoxin domain containing 5

increases expression

fenpyroximate results in increased expression of TXNDC5 mRNA

NCBI chr17:26,289,880...26,318,025
Ensembl chr17:26,289,880...26,318,025

G

thioredoxin interacting protein

decreases expression

fenpyroximate results in decreased expression of TXNIP mRNA

NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886

G

thioredoxin reductase 1

increases expression

fenpyroximate results in increased expression of TXNRD1 mRNA

NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863

G

ubiquitin A-52 residue ribosomal protein fusion product 1

increases expression

fenpyroximate results in increased expression of UBA52 mRNA

NCBI chr16:18,918,614...18,920,807
Ensembl chr16:18,900,616...18,920,807

G

ubiquitin-conjugating enzyme E2C

increases expression

fenpyroximate results in increased expression of UBE2C mRNA

NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339

G

ubiquitin conjugating enzyme E2 Q2

decreases expression

fenpyroximate results in decreased expression of UBE2Q2 mRNA

NCBI chr 8:55,518,402...55,578,342
Ensembl chr 8:55,519,147...55,577,212

G

ubiquinol-cytochrome c reductase, complex III subunit VII

increases expression

fenpyroximate results in increased expression of UQCRQ mRNA

NCBI chr10:37,585,864...37,589,328
Ensembl chr10:37,586,888...37,589,169

G

VAMP associated protein B and C

decreases expression

fenpyroximate results in decreased expression of VAPB mRNA

NCBI chr 3:162,535,974...162,578,747
Ensembl chr 3:162,535,905...162,573,763

G

vascular endothelial growth factor A

increases expression

fenpyroximate results in increased expression of VEGFA mRNA

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

vestigial-like family member 4

decreases expression

fenpyroximate results in decreased expression of VGLL4 mRNA

NCBI chr 4:147,925,630...148,038,519
Ensembl chr 4:147,927,034...148,038,471

G

vacuolar protein sorting 72 homolog

decreases expression

fenpyroximate results in decreased expression of VPS72 mRNA

NCBI chr 2:182,678,594...182,690,185
Ensembl chr 2:182,678,609...182,690,182

G

tryptophanyl-tRNA synthetase 1

increases expression

fenpyroximate results in increased expression of WARS1 mRNA

NCBI chr 6:127,776,088...127,807,273
Ensembl chr 6:127,776,090...127,807,269

G

X-box binding protein 1

increases expression

fenpyroximate results in increased expression of XBP1 mRNA

NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta

decreases expression

fenpyroximate results in decreased expression of YWHAB mRNA

NCBI chr 3:152,659,663...152,682,105
Ensembl chr 3:152,659,651...152,682,105

G

zinc finger and BTB domain containing 41

decreases expression

fenpyroximate results in decreased expression of ZBTB41 mRNA

NCBI chr13:51,042,948...51,065,768
Ensembl chr13:51,042,948...51,065,768

G

zinc finger AN1-type containing 2A

increases expression

fenpyroximate results in increased expression of ZFAND2A mRNA

NCBI chr12:15,161,601...15,172,679
Ensembl chr12:15,161,639...15,172,677

G

zinc finger RANBP2-type containing 2

increases expression

fenpyroximate results in increased expression of ZRANB2 mRNA

NCBI chr 2:246,573,110...246,586,942
Ensembl chr 2:246,573,166...246,586,942

fipronil

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

RIKEN cDNA 1700009N14 gene like

decreases expression

fipronil results in decreased expression of 1700009N14RIKL mRNA

NCBI chr 5:54,456,005...54,457,381
Ensembl chr 5:54,455,893...54,457,677

G

4921524L21Rikl1

RIKEN cDNA 4921524L21 gene like 1

multiple interactions

[fipronil co-treated with DEET] results in decreased expression of CCDC144BP mRNA

NCBI chr17:54,808,184...54,847,675
Ensembl chr17:54,808,184...54,847,671
Ensembl chr17:54,808,184...54,847,671

G

AP2 associated kinase 1

decreases expression

fipronil results in decreased expression of AAK1 mRNA

NCBI chr 4:119,300,128...119,451,834
Ensembl chr 4:119,295,257...119,450,969

G

apoptosis antagonizing transcription factor

increases expression

fipronil results in increased expression of AATF mRNA

NCBI chr10:69,299,029...69,392,207
Ensembl chr10:69,299,037...69,392,201

G

ATP binding cassette subfamily B member 1A

increases expression

fipronil results in increased expression of ABCB1A mRNA

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP-binding cassette, sub-family B member 1B

increases expression

fipronil results in increased expression of ABCB1B mRNA

NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199

G

ATP binding cassette subfamily C member 2

increases expression

fipronil results in increased expression of ABCC2 mRNA

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 3

increases expression
multiple interactions

fipronil results in increased expression of ABCC3 mRNA
NR1I2 gene mutant form inhibits the reaction [fipronil results in increased expression of ABCC3 mRNA]

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

ATP binding cassette subfamily C member 4

increases expression

fipronil results in increased expression of ABCC4 mRNA

NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283

G

ATP binding cassette subfamily G member 5

increases expression

fipronil results in increased expression of ABCG5 mRNA

NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563

G

ATP binding cassette subfamily G member 8

increases expression

fipronil results in increased expression of ABCG8 mRNA

NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912

G

acetyl-CoA carboxylase alpha

multiple interactions
decreases expression
increases expression

AICA ribonucleotide inhibits the reaction [fipronil results in increased expression of and results in decreased phosphorylation of ACACA protein]; fipronil results in increased expression of and results in decreased phosphorylation of ACACA protein
fipronil results in decreased expression of ACACA mRNA
fipronil results in increased expression of ACACA mRNA

PMID:27103584 PMID:38050659

NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457

G

acetyl-CoA carboxylase beta

affects expression

fipronil affects the expression of ACACB mRNA

NCBI chr12:42,365,800...42,477,651
Ensembl chr12:42,366,548...42,457,655

G

alkaline ceramidase 2

increases expression

fipronil results in increased expression of ACER2 mRNA

NCBI chr 5:101,391,830...101,442,615
Ensembl chr 5:101,391,885...101,442,614

G

acid phosphatase 1

increases expression

fipronil results in increased expression of ACP1 mRNA

NCBI chr 6:47,506,380...47,522,021
Ensembl chr 6:47,506,380...47,522,021

G

acid phosphatase 2, lysosomal

increases expression

fipronil results in increased expression of ACP2 mRNA

NCBI chr 3:77,175,022...77,185,180
Ensembl chr 3:77,175,895...77,185,680

G

actin, beta

increases expression

fipronil results in increased expression of ACTB mRNA

PMID:31881178 PMID:34044035

NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877

G

actin gamma 2, smooth muscle

increases expression

fipronil results in increased expression of ACTG2 mRNA

NCBI chr 4:116,021,832...116,046,475
Ensembl chr 4:116,021,832...116,046,465

G

actin related protein 1B

decreases expression

fipronil results in decreased expression of ACTR1B mRNA

NCBI chr 9:38,928,819...38,938,483
Ensembl chr 9:38,929,912...38,938,507

G

adenosine deaminase

increases expression

fipronil results in increased expression of ADA mRNA

NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088

G

ADAM metallopeptidase domain 1a

decreases expression
multiple interactions

fipronil results in decreased expression of ADAM1A mRNA
[fipronil co-treated with DEET] results in decreased expression of ADAM1A mRNA

NCBI chr12:35,017,433...35,020,300
Ensembl chr12:35,017,315...35,020,311

G

ADAM metallopeptidase with thrombospondin type 1 motif, 1

decreases expression

fipronil results in decreased expression of ADAMTS1 mRNA

NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103

G

ADAMTS-like 2

increases expression

fipronil results in increased expression of ADAMTSL2 mRNA

NCBI chr 3:10,397,774...10,434,557
Ensembl chr 3:10,404,626...10,434,554

G

adhesion G protein-coupled receptor F5

increases expression

fipronil results in increased expression of ADGRF5 mRNA

NCBI chr 9:17,517,596...17,624,107
Ensembl chr 9:17,520,009...17,623,968

G

adhesion G protein-coupled receptor G1

increases expression

fipronil results in increased expression of ADGRG1 mRNA

NCBI chr19:10,003,963...10,041,122
Ensembl chr19:10,003,975...10,041,108

G

alcohol dehydrogenase 4 (class II), pi polypeptide

increases expression

fipronil results in increased expression of ADH4 mRNA

NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591

G

adrenoceptor alpha 1A

decreases expression
multiple interactions

fipronil results in decreased expression of ADRA1A mRNA
[fipronil co-treated with DEET] results in decreased expression of ADRA1A mRNA

NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500

G

adrenoceptor alpha 1B

multiple interactions

[fipronil co-treated with DEET] results in decreased expression of ADRA1B mRNA

NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919

G

adrenoceptor alpha 2A

increases expression

fipronil results in increased expression of ADRA2A mRNA

NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365

G

adrenoceptor alpha 2C

multiple interactions
increases expression

[fipronil co-treated with DEET] results in increased expression of ADRA2C mRNA
fipronil results in increased expression of ADRA2C mRNA

NCBI chr14:75,470,884...75,472,846
Ensembl chr14:75,471,143...75,472,846

G

adrenoceptor beta 1

multiple interactions
increases expression

[fipronil co-treated with DEET] results in increased expression of ADRB1 mRNA
fipronil results in increased expression of ADRB1 mRNA

NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259

G

adrenoceptor beta 2

increases expression
multiple interactions

fipronil results in increased expression of ADRB2 mRNA
[fipronil co-treated with DEET] results in increased expression of ADRB2 mRNA

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

G

apoptosis enhancing nuclease

decreases expression

fipronil results in decreased expression of AEN mRNA

NCBI chr 1:132,815,094...132,824,522
Ensembl chr 1:132,815,142...132,824,523

G

AFG2 AAA ATPase homolog A

decreases expression

fipronil results in decreased expression of AFG2A mRNA

NCBI chr 2:120,306,417...120,497,707
Ensembl chr 2:120,306,412...120,497,705

G

ArfGAP with GTPase domain, ankyrin repeat and PH domain 2

increases expression

fipronil results in increased expression of AGAP2 mRNA

NCBI chr 7:62,897,282...62,914,295
Ensembl chr 7:62,897,282...62,914,295

G

argonaute RISC catalytic component 2

increases expression

fipronil results in increased expression of AGO2 mRNA

NCBI chr 7:105,018,202...105,105,118
Ensembl chr 7:105,029,120...105,104,974

G

alkylglycerone phosphate synthase

increases expression

fipronil results in increased expression of AGPS mRNA

NCBI chr 3:60,747,323...60,845,831
Ensembl chr 3:60,747,323...60,845,830

G

ATP/GTP binding carboxypeptidase 1

increases expression

fipronil results in increased expression of AGTPBP1 mRNA

NCBI chr17:5,120,540...5,238,874
Ensembl chr17:5,120,609...5,238,869

G

alanine--glyoxylate aminotransferase

decreases expression

fipronil results in decreased expression of AGXT mRNA

NCBI chr 9:93,675,384...93,685,337
Ensembl chr 9:93,675,384...93,685,336

G

AT hook, DNA binding motif, containing 1

increases expression

fipronil results in increased expression of AHDC1 mRNA

NCBI chr 5:145,228,228...145,294,170
Ensembl chr 5:145,228,227...145,294,145

G

Abelson helper integration site 1

increases expression

fipronil results in increased expression of AHI1 mRNA

NCBI chr 1:15,762,485...15,891,213
Ensembl chr 1:15,762,462...15,891,041

G

aryl hydrocarbon receptor

affects expression

fipronil affects the expression of AHR mRNA

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

activator of Hsp90 ATPase activity 1

decreases expression

fipronil results in decreased expression of AHSA1 mRNA

NCBI chr 6:106,913,296...106,921,347
Ensembl chr 6:106,913,530...106,921,345

G

axin interactor, dorsalization associated

decreases expression

fipronil results in decreased expression of AIDA mRNA

NCBI chr13:94,940,311...94,967,920
Ensembl chr13:94,939,741...94,967,920

G

aminoacyl tRNA synthetase complex-interacting multifunctional protein 2

decreases expression

fipronil results in decreased expression of AIMP2 mRNA

NCBI chr12:10,701,194...10,710,772
Ensembl chr12:10,701,194...10,710,769

G

A-kinase anchoring protein 13

decreases expression

fipronil results in decreased expression of AKAP13 mRNA

NCBI chr 1:129,313,183...129,619,647
Ensembl chr 1:129,314,402...129,619,646

G

aldo-keto reductase family 1 member B1

increases expression

fipronil results in increased expression of AKR1B1 mRNA

NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157

G

aldo-keto reductase family 1, member C12-like 1

increases expression

fipronil results in increased expression of AKR1C12L1 mRNA

NCBI chr17:65,937,834...65,948,344
Ensembl chr17:65,937,814...65,997,595
Ensembl chr17:65,937,814...65,997,595

G

aldo-keto reductase family 1, member C15

decreases expression
multiple interactions

fipronil results in decreased expression of AKR1C8 mRNA
[fipronil co-treated with DEET] results in decreased expression of AKR1C8 mRNA

NCBI chr17:66,181,493...66,208,090
Ensembl chr17:66,181,493...66,208,061

G

aldo-keto reductase family 1 member C3-like 1

increases expression

fipronil results in increased expression of AKR1C3L1 mRNA

NCBI chr17:65,847,580...65,881,488
Ensembl chr17:65,835,634...65,881,488

G

aldo-keto reductase family 1, member E2

increases expression

fipronil results in increased expression of AKR1E2 mRNA

NCBI chr17:65,735,909...65,750,441
Ensembl chr17:65,735,943...65,750,441

G

aldo-keto reductase family 7 member A3

increases expression

fipronil results in increased expression of AKR7A3 mRNA

NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394

G

albumin

decreases expression
multiple interactions

fipronil results in decreased expression of ALB protein
Plant Extracts inhibits the reaction [fipronil results in decreased expression of ALB protein]

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

aldehyde dehydrogenase 1 family, member A1

increases expression

fipronil results in increased expression of ALDH1A1 mRNA

PMID:23962444 PMID:31881178

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

aldehyde dehydrogenase 1 family, member B1

decreases expression

fipronil results in decreased expression of ALDH1B1 mRNA

NCBI chr 5:60,063,370...60,068,378
Ensembl chr 5:60,063,225...60,068,378

G

aldehyde dehydrogenase 7 family, member A1

increases expression

fipronil results in increased expression of ALDH7A1 mRNA

NCBI chr18:50,003,242...50,042,193
Ensembl chr18:50,009,934...50,042,193

G

alkaline phosphatase, intestinal

multiple interactions
increases expression

[fipronil co-treated with DEET] results in increased expression of ALPI mRNA
fipronil results in increased expression of ALPI mRNA

NCBI chr 9:87,773,411...87,776,877
Ensembl chr 9:87,773,411...87,776,877

G

alkaline phosphatase, biomineralization associated

multiple interactions

fipronil inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

adenosylmethionine decarboxylase 1

decreases expression

fipronil results in decreased expression of AMD1 mRNA

NCBI chr20:43,695,783...43,711,476
Ensembl chr20:43,697,237...43,711,476

G

antagonist of mitotic exit network 1 homolog

increases expression

fipronil results in increased expression of AMN1 mRNA

NCBI chr 4:182,155,140...182,182,085
Ensembl chr 4:182,155,142...182,182,016

G

archaelysin family metallopeptidase 2

increases expression

fipronil results in increased expression of AMZ2 mRNA

NCBI chr10:94,401,546...94,412,116
Ensembl chr10:94,401,579...94,412,114

G

angiopoietin-like 2

decreases expression

fipronil results in decreased expression of ANGPTL2 mRNA

NCBI chr 3:16,517,185...16,547,024
Ensembl chr 3:16,517,420...16,548,178

G

angiopoietin-like 3

increases expression

fipronil results in increased expression of ANGPTL3 mRNA

NCBI chr 5:113,703,007...113,710,044
Ensembl chr 5:113,703,012...113,709,957

G

anoctamin 10

increases expression

fipronil results in increased expression of ANO10 mRNA

NCBI chr 8:121,841,664...121,960,739
Ensembl chr 8:121,841,665...121,962,670

G

aldehyde oxidase 1

increases expression

fipronil results in increased expression of AOX1 mRNA

NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:59,579,649...59,658,770

G

adaptor related protein complex 1 subunit gamma 2

decreases expression

fipronil results in decreased expression of AP1G2 mRNA

NCBI chr15:28,571,571...28,579,421
Ensembl chr15:28,571,568...28,589,004

G

adaptor related protein complex 1 subunit sigma 3

decreases expression

fipronil results in decreased expression of AP1S3 mRNA

NCBI chr 9:80,950,402...81,009,889
Ensembl chr 9:80,950,715...81,009,798

G

adaptor related protein complex 2 subunit alpha 2

decreases expression

fipronil results in decreased expression of AP2A2 mRNA

NCBI chr 1:196,652,315...196,725,609
Ensembl chr 1:196,652,337...196,725,603

G

adaptor related protein complex 2 subunit mu 1

increases expression

fipronil results in increased expression of AP2M1 mRNA

NCBI chr11:80,355,307...80,364,218
Ensembl chr11:80,328,041...80,364,140

G

adaptor related protein complex 3 subunit delta 1

increases expression

fipronil results in increased expression of AP3D1 mRNA

NCBI chr 7:8,970,249...9,005,651
Ensembl chr 7:8,970,291...9,005,643

G

amyloid beta precursor protein binding family A member 3

increases expression

fipronil results in increased expression of APBA3 mRNA

NCBI chr 7:8,446,212...8,451,310
Ensembl chr 7:8,446,216...8,451,241

G

adipocyte plasma membrane associated protein

decreases expression

fipronil results in decreased expression of APMAP mRNA

NCBI chr 3:139,409,021...139,437,296
Ensembl chr 3:139,409,022...139,437,341

G

apolipoprotein B mRNA editing enzyme catalytic subunit 3

decreases expression

fipronil results in decreased expression of APOBEC3 mRNA

NCBI chr 7:111,433,789...111,453,032
Ensembl chr 7:111,433,764...111,452,922

G

amyloid beta precursor protein

increases expression

fipronil results in increased expression of APP mRNA

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

aquaporin 9

decreases expression

fipronil results in decreased expression of AQP9 mRNA

PMID:23962444 PMID:34044035

NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395

G

androgen receptor

multiple interactions

[fipronil co-treated with DEET] results in decreased expression of AR mRNA; fipronil inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]

PMID:27091632 PMID:28728110

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

amphiregulin

increases expression

fipronil results in increased expression of AREG mRNA

NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535

G

apoptosis resistant E3 ubiquitin protein ligase 1

decreases expression

fipronil results in decreased expression of AREL1 mRNA

NCBI chr 6:104,560,556...104,617,712
Ensembl chr 6:104,564,986...104,617,628

G

ARF GTPase 4

decreases expression

fipronil results in decreased expression of ARF4 mRNA

NCBI chr16:1,896,692...1,913,267
Ensembl chr16:1,896,546...1,913,261

G

arginase 1

decreases expression

fipronil results in decreased expression of ARG1 mRNA

PMID:32194361 PMID:34044035

NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422

G

Rho GDP dissociation inhibitor alpha

decreases expression

fipronil results in decreased expression of ARHGDIA mRNA

NCBI chr10:105,854,526...105,858,020
Ensembl chr10:105,854,533...105,858,023

G

Rho guanine nucleotide exchange factor 19

decreases expression

fipronil results in decreased expression of ARHGEF19 mRNA

NCBI chr 5:153,536,038...153,554,203
Ensembl chr 5:153,536,013...153,554,203

G

Rho guanine nucleotide exchange factor 28

increases expression

fipronil results in increased expression of ARHGEF28 mRNA

NCBI chr 2:29,263,888...29,560,595
Ensembl chr 2:29,263,886...29,560,672

G

ARF like GTPase 6 interacting protein 5

increases expression

fipronil results in increased expression of ARL6IP5 mRNA

NCBI chr 4:129,810,650...129,838,628
Ensembl chr 4:129,810,645...129,838,608

G

asialoglycoprotein receptor 1

decreases expression

fipronil results in decreased expression of ASGR1 mRNA

NCBI chr10:54,775,727...54,779,642
Ensembl chr10:54,776,024...54,779,631

G

asparaginase

increases expression

fipronil results in increased expression of ASPG mRNA

NCBI chr 6:131,176,727...131,196,268
Ensembl chr 6:131,176,874...131,196,268

G

activating transcription factor 6

increases expression

fipronil results in increased expression of ATF6 mRNA

NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177

G

ATPase phospholipid transporting 11C

increases expression

fipronil results in increased expression of ATP11C mRNA

NCBI chr X:138,564,459...138,752,116
Ensembl chr X:138,565,836...138,751,204

G

ATPase Na+/K+ transporting subunit beta 3

decreases expression

fipronil results in decreased expression of ATP1B3 mRNA

NCBI chr 8:96,910,265...96,941,592
Ensembl chr 8:96,910,309...96,941,598
Ensembl chr 8:96,910,309...96,941,598

G

ATP synthase inhibitory factor subunit 1

increases expression

fipronil results in increased expression of ATP5IF1 mRNA

NCBI chr 5:144,738,950...144,742,668
Ensembl chr 5:144,738,950...144,742,668

G

ATP synthase membrane subunit c locus 1

decreases expression

fipronil results in decreased expression of ATP5MC1 mRNA

NCBI chr10:81,024,056...81,026,780
Ensembl chr10:81,023,925...81,027,124
Ensembl chr10:81,023,925...81,027,124

G

ATP synthase membrane subunit c locus 1 like 2

decreases expression

fipronil results in decreased expression of ATP5MC1L2 mRNA

NCBI chr 6:66,654,187...66,654,763
Ensembl chr 6:66,654,294...66,654,692

G

ATPase H+ transporting V1 subunit E1

increases expression

fipronil results in increased expression of ATP6V1E1 mRNA

NCBI chr 4:154,022,358...154,044,486
Ensembl chr 4:154,022,358...154,044,584

G

ATR serine/threonine kinase

increases expression

fipronil results in increased expression of ATR mRNA

NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136

G

ataxin 7-like 1

decreases expression

fipronil results in decreased expression of ATXN7L1 mRNA

NCBI chr 6:49,759,876...49,982,323
Ensembl chr 6:49,759,883...49,982,320

G

ataxin 7-like 3B

affects expression

fipronil affects the expression of ATXN7L3B mRNA

NCBI chr 7:48,322,451...48,325,975
Ensembl chr 7:48,321,755...48,328,878

G

AU RNA binding methylglutaconyl-CoA hydratase

increases expression

fipronil results in increased expression of AUH mRNA

NCBI chr17:12,329,522...12,424,882
Ensembl chr17:12,329,524...12,424,896

G

AUP1, lipid droplet regulating VLDL assembly factor

increases expression

fipronil results in increased expression of AUP1 mRNA

NCBI chr 4:115,560,274...115,563,346
Ensembl chr 4:115,560,261...115,563,346

G

aurora kinase A

decreases expression

fipronil results in decreased expression of AURKA mRNA

NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390

G

arginine vasopressin-induced 1

increases expression

fipronil results in increased expression of AVPI1 mRNA

NCBI chr 1:240,930,236...240,936,154
Ensembl chr 1:240,930,236...240,936,154

G

arginine vasopressin receptor 1B

decreases expression

fipronil results in decreased expression of AVPR1B mRNA

NCBI chr13:43,046,531...43,059,046
Ensembl chr13:43,046,267...43,057,792

G

alpha-2-glycoprotein 1, zinc-binding

decreases expression

fipronil results in decreased expression of AZGP1 mRNA

NCBI chr12:16,930,990...16,939,333
Ensembl chr12:16,931,024...16,939,091

G

beta-1,4-galactosyltransferase 1

decreases expression

fipronil results in decreased expression of B4GALT1 mRNA

NCBI chr 5:55,935,614...55,982,461
Ensembl chr 5:55,935,615...55,982,461

G

BAR/IMD domain containing adaptor protein 2 like 1

decreases expression

fipronil results in decreased expression of BAIAP2L1 mRNA

NCBI chr12:10,250,434...10,339,937
Ensembl chr12:10,250,473...10,339,928

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

Allopurinol inhibits the reaction [fipronil results in increased expression of BAX mRNA]; Plant Extracts inhibits the reaction [fipronil results in increased expression of BAX mRNA]

PMID:30777931 PMID:36916050

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCAS2, pre-mRNA processing factor

decreases expression

fipronil results in decreased expression of BCAS2 mRNA

NCBI chr 2:190,692,503...190,700,386
Ensembl chr 2:190,692,461...190,700,389

G

BCL2, apoptosis regulator

decreases expression
multiple interactions

fipronil results in decreased expression of BCL2 protein
Allopurinol inhibits the reaction [fipronil results in decreased expression of BCL2 mRNA]

PMID:21296133 PMID:34352653 PMID:36916050

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

brain-enriched guanylate kinase-associated

increases expression

fipronil results in increased expression of BEGAIN mRNA

NCBI chr 6:127,943,651...127,979,876
Ensembl chr 6:127,943,651...127,979,841

G

BICD family like cargo adaptor 1

increases expression

fipronil results in increased expression of BICDL1 mRNA

NCBI chr12:40,878,190...41,001,152
Ensembl chr12:40,876,884...40,966,130

G

BICD family like cargo adaptor 2

increases expression

fipronil results in increased expression of BICDL2 mRNA

NCBI chr10:12,691,610...12,700,049
Ensembl chr10:12,691,610...12,700,049

G

bridging integrator 1

increases expression

fipronil results in increased expression of BIN1 mRNA

NCBI chr18:24,009,731...24,067,267
Ensembl chr18:24,009,653...24,067,263

G

bone morphogenetic protein 1

decreases expression

fipronil results in decreased expression of BMP1 mRNA

NCBI chr15:45,551,603...45,595,862
Ensembl chr15:45,551,603...45,595,776

G

bone morphogenetic protein 2

increases expression

fipronil results in increased expression of BMP2 mRNA

NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397

G

brain protein I3

decreases expression

fipronil results in decreased expression of BRI3 mRNA

NCBI chr12:10,341,007...10,364,655
Ensembl chr12:10,341,011...10,364,735

G

BMP/retinoic acid inducible neural specific 2

multiple interactions

[fipronil co-treated with DEET] results in increased expression of BRINP2 mRNA

NCBI chr13:70,431,006...70,532,766
Ensembl chr13:70,431,010...70,531,810

G

BRO1 domain and CAAX motif containing

decreases expression

fipronil results in decreased expression of BROX mRNA

NCBI chr13:94,920,107...94,940,189
Ensembl chr13:94,920,112...94,940,227

G

BTB domain containing 3

increases expression

fipronil results in increased expression of BTBD3 mRNA

NCBI chr 3:125,591,427...125,621,660
Ensembl chr 3:125,591,490...125,619,038

G

BTG anti-proliferation factor 1

increases expression

fipronil results in increased expression of BTG1 mRNA

NCBI chr 7:31,341,391...31,343,649
Ensembl chr 7:31,341,027...31,343,649

G

BTG anti-proliferation factor 3

decreases expression

fipronil results in decreased expression of BTG3 mRNA

NCBI chr11:17,030,156...17,046,069
Ensembl chr11:17,030,160...17,046,170

G

BUD31 homolog

decreases expression

fipronil results in decreased expression of BUD31 mRNA

NCBI chr12:9,462,838...9,470,387
Ensembl chr12:9,462,441...9,470,509

G

chromosome 11 C3orf85 homolog

decreases expression

fipronil results in decreased expression of C3ORF85 mRNA

Ensembl chr11:52,408,892...52,420,176

G

similar to human chromosome 1 open reading frame 53

increases expression

fipronil results in increased expression of C13H1ORF53 mRNA

NCBI chr13:50,413,785...50,418,974
Ensembl chr13:50,413,785...50,419,120

G

similar to human chromosome 10 open reading frame 143

decreases expression
multiple interactions

fipronil results in decreased expression of C10ORF143 mRNA
[fipronil co-treated with DEET] results in decreased expression of C10ORF143 mRNA

NCBI chr 1:192,184,440...192,222,676
Ensembl chr 1:192,184,445...192,222,398

G

similar to human chromosome 15 open reading frame 40

increases expression

fipronil results in increased expression of C1H15ORF40 mRNA

NCBI chr 1:135,725,869...135,732,028
Ensembl chr 1:135,717,545...135,732,039

G

similar to human chromosome 2 open reading frame 42

decreases expression

fipronil results in decreased expression of C4H2ORF42 mRNA

NCBI chr 4:118,887,688...118,916,808
Ensembl chr 4:118,888,112...118,916,936

G

complement C8 gamma chain

increases expression

fipronil results in increased expression of C8G mRNA

NCBI chr 3:8,320,503...8,322,087
Ensembl chr 3:8,305,920...8,323,495

G

similar to human chromosome 11 open reading frame 54

increases expression

fipronil results in increased expression of C8H11ORF54 mRNA

NCBI chr 8:12,123,839...12,146,412
Ensembl chr 8:12,123,823...12,146,473

G

similar to human chromosome 2 open reading frame 92

multiple interactions
decreases expression

[fipronil co-treated with DEET] results in decreased expression of C2ORF92 mRNA
fipronil results in decreased expression of C2ORF92 mRNA

NCBI chr 9:38,943,927...38,984,878
Ensembl chr 9:38,944,526...38,985,127

G

calcium binding protein 4

multiple interactions
decreases expression

[fipronil co-treated with DEET] results in decreased expression of CABP4 mRNA
fipronil results in decreased expression of CABP4 mRNA

NCBI chr 1:201,428,671...201,442,950
Ensembl chr 1:201,428,672...201,433,172

G

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

decreases expression

fipronil results in decreased expression of CAD mRNA

NCBI chr 6:25,292,133...25,315,078
Ensembl chr 6:25,292,133...25,319,861

G

calcitonin-related polypeptide, beta

increases expression
multiple interactions

fipronil results in increased expression of CALCB mRNA
[fipronil co-treated with DEET] results in increased expression of CALCB mRNA

NCBI chr 1:168,965,383...168,970,259
Ensembl chr 1:168,966,465...168,970,125

G

calcium homeostasis modulator family member 4

multiple interactions
increases expression

[fipronil co-treated with DEET] results in increased expression of CALHM4 mRNA
fipronil results in increased expression of CALHM4 mRNA

NCBI chr20:25,990,164...25,993,173
Ensembl chr20:25,990,462...25,993,173

G

calmodulin-like 4

increases expression

fipronil results in increased expression of CALML4 mRNA

NCBI chr 8:63,323,426...63,335,234
Ensembl chr 8:63,323,351...63,335,234

G

calcyon neuron-specific vesicular protein

decreases expression

fipronil results in decreased expression of CALY mRNA

NCBI chr 1:194,862,671...194,873,861
Ensembl chr 1:194,862,672...194,873,551

G

calcium/calmodulin-dependent protein kinase II inhibitor 1

increases expression

fipronil results in increased expression of CAMK2N1 mRNA

NCBI chr 5:150,674,819...150,676,600
Ensembl chr 5:150,673,507...150,676,600

G

calpain 2

increases expression

fipronil results in increased expression of CAPN2 mRNA

NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969

G

calpain 5

increases expression

fipronil results in increased expression of CAPN5 mRNA

NCBI chr 1:152,416,252...152,472,923
Ensembl chr 1:152,416,252...152,472,923

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carbonic anhydrase 12

increases expression
multiple interactions

fipronil results in increased expression of CA12 mRNA
[fipronil co-treated with DEET] results in increased expression of CA12 mRNA

NCBI chr 8:67,274,739...67,330,428
Ensembl chr 8:67,274,359...67,330,440

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carbonic anhydrase 4

decreases expression

fipronil results in decreased expression of CA4 mRNA

NCBI chr10:69,827,945...69,836,501
Ensembl chr10:69,827,945...69,836,501

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carbonic anhydrase 8

increases expression

fipronil results in increased expression of CAR8 mRNA

NCBI chr 5:21,302,940...21,402,395
Ensembl chr 5:21,305,383...21,402,374

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calcium regulated heat stable protein 1

decreases expression

fipronil results in decreased expression of CARHSP1 mRNA

NCBI chr10:6,946,036...6,960,556
Ensembl chr10:6,946,959...7,020,019

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caspase 3

multiple interactions
increases expression
increases activity

kenpaullone inhibits the reaction [fipronil results in increased activity of CASP3 protein]; Lithium Chloride inhibits the reaction [fipronil results in increased activity of CASP3 protein]
fipronil results in increased expression of CASP3 mRNA; fipronil results in increased expression of CASP3 protein
Allopurinol inhibits the reaction [fipronil results in increased expression of CASP3 mRNA]; Plant Extracts inhibits the reaction [fipronil results in increased expression of CASP3 mRNA]

PMID:17084830 PMID:21296133 PMID:21621551 PMID:22421270 PMID:30777931 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

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caspase 7

increases activity

fipronil results in increased activity of CASP7 protein

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

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caspase 9

increases activity

fipronil results in increased activity of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

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catalase

multiple interactions
decreases expression
increases activity
affects binding
decreases activity

Ascorbic Acid inhibits the reaction [fipronil results in decreased activity of CAT protein]; Vitamin E inhibits the reaction [fipronil results in decreased activity of CAT protein]
fipronil results in decreased expression of CAT mRNA
fipronil results in increased activity of CAT protein
fipronil results in decreased expression of CAT protein
fipronil binds to CAT protein
Allopurinol inhibits the reaction [fipronil results in increased activity of CAT protein]; Plant Extracts inhibits the reaction [fipronil results in decreased activity of CAT protein]

PMID:25721553 PMID:30777931 PMID:32278787 PMID:32651782 PMID:36113622 More...

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

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caveolin 1

decreases expression

fipronil results in decreased expression of CAV1 mRNA

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

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Cbl proto-oncogene

increases expression

fipronil results in increased expression of CBL mRNA

NCBI chr 8:44,487,824...44,571,620
Ensembl chr 8:44,489,410...44,571,176

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Cbl proto-oncogene like 1

increases expression

fipronil results in increased expression of CBLL1 mRNA

PMID:23962444 PMID:31881178

NCBI chr 6:48,071,190...48,086,174
Ensembl chr 6:48,071,190...48,086,444

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coiled-coil domain containing 102A

increases expression

fipronil results in increased expression of CCDC102A mRNA

PMID:31881178 PMID:34044035

NCBI chr19:10,102,543...10,118,657
Ensembl chr19:10,103,361...10,118,657

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coiled-coil domain containing 120

increases expression

fipronil results in increased expression of CCDC120 mRNA

NCBI chr X:14,753,594...14,772,745
Ensembl chr X:14,753,696...14,772,743

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coiled-coil domain containing 136

increases expression

fipronil results in increased expression of CCDC136 mRNA

NCBI chr 4:57,997,825...58,027,598
Ensembl chr 4:57,997,853...58,027,646

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coiled-coil domain containing 17

increases expression
decreases expression

fipronil results in increased expression of CCDC17 mRNA
fipronil results in decreased expression of CCDC17 mRNA

PMID:23962444 PMID:34044035

NCBI chr 5:130,051,158...130,056,676
Ensembl chr 5:130,045,938...130,056,673

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coiled-coil domain containing 200

multiple interactions

[fipronil co-treated with DEET] results in decreased expression of CCDC200 mRNA

NCBI chr10:86,517,704...86,523,106
Ensembl chr10:86,517,683...86,523,038

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coiled-coil domain containing 80

increases expression

fipronil results in increased expression of CCDC80 mRNA

NCBI chr11:55,685,165...55,718,827
Ensembl chr11:55,685,872...55,719,137

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C-C motif chemokine ligand 2

decreases expression

fipronil results in decreased expression of CCL2 mRNA

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

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cellular communication network factor 2

increases expression

fipronil results in increased expression of CCN2 mRNA

NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734

G

cellular communication network factor 3

decreases expression

fipronil results in decreased expression of CCN3 mRNA

NCBI chr 7:86,094,000...86,101,022
Ensembl chr 7:86,094,000...86,101,019

G

cyclin B1

increases expression

fipronil results in increased expression of CCNB1 mRNA

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

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cyclin Q

increases expression

fipronil results in increased expression of CCNQ mRNA

NCBI chr10:63,646,532...63,647,695
Ensembl chr10:63,646,527...63,647,961

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chaperonin containing TCP1 subunit 6A

decreases expression

fipronil results in decreased expression of CCT6A mRNA

NCBI chr12:26,872,736...26,883,125
Ensembl chr12:26,872,574...26,883,337

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CD14 molecule

increases expression

fipronil results in increased expression of CD14 mRNA

NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261

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CD151 molecule (Raph blood group)

increases expression

fipronil results in increased expression of CD151 mRNA

NCBI chr 1:196,564,744...196,568,753
Ensembl chr 1:196,565,181...196,568,753

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CD302 molecule

increases expression

fipronil results in increased expression of CD302 mRNA

PMID:23962444 PMID:34044035

NCBI chr 3:44,722,324...44,756,045
Ensembl chr 3:44,722,325...44,756,045

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CD36 molecule

decreases expression
affects expression

fipronil results in decreased expression of CD36 mRNA
fipronil affects the expression of CD36 mRNA

PMID:23962444 PMID:38050659

NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903

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CD44 molecule

increases expression

fipronil results in increased expression of CD44 mRNA

NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620

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CD59b molecule

increases expression

fipronil results in increased expression of CD59 mRNA

NCBI chr 3:90,459,085...90,477,571
Ensembl chr 3:90,459,162...90,478,847

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cytidine deaminase

increases expression

fipronil results in increased expression of CDA mRNA

NCBI chr 5:150,556,615...150,583,231
Ensembl chr 5:150,556,615...150,583,231

G

cyclin-dependent kinase 1

increases expression

fipronil results in increased expression of CDK1 mRNA

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

cyclin-dependent kinase 11B

increases expression

fipronil results in increased expression of CDK11B mRNA

NCBI chr 5:166,212,761...166,238,883
Ensembl chr 5:166,212,829...166,238,876

G

cyclin dependent kinase 2

decreases expression

fipronil results in decreased expression of CDK2 mRNA

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase 7

decreases expression

fipronil results in decreased expression of CDK7 mRNA

NCBI chr 2:31,840,558...31,865,422
Ensembl chr 2:31,840,558...31,865,383

G

cyclin-dependent kinase inhibitor 3

increases expression

fipronil results in increased expression of CDKN3 mRNA

NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945

G

CCAAT/enhancer binding protein alpha

multiple interactions
increases expression

AICA ribonucleotide inhibits the reaction [fipronil results in increased expression of CEBPA protein]
fipronil results in increased expression of CEBPA mRNA; fipronil results in increased expression of CEBPA protein

NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412

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CCAAT/enhancer binding protein delta

increases expression

fipronil results in increased expression of CEBPD mRNA

NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829

G

centromere protein S

decreases expression

fipronil results in decreased expression of CENPS mRNA

NCBI chr 5:159,563,917...159,573,534

G

centromere protein V

decreases expression

fipronil results in decreased expression of CENPV mRNA

NCBI chr10:47,214,479...47,228,552
Ensembl chr10:47,214,490...47,228,761

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centrosomal protein 15

increases expression

fipronil results in increased expression of CEP15 mRNA

NCBI chr15:12,815,159...12,835,115
Ensembl chr15:12,818,385...12,833,838

G

centrosomal protein 20

increases expression
decreases expression

fipronil results in increased expression of CEP20 mRNA
fipronil results in decreased expression of CEP20 mRNA

PMID:23962444 PMID:34044035

NCBI chr10:714,051...736,826
Ensembl chr10:714,151...736,837

G

centrosomal protein 44

decreases expression

fipronil results in decreased expression of CEP44 mRNA

NCBI chr16:33,711,548...33,733,226
Ensembl chr16:33,711,559...33,733,225

G

ceramide transporter 1

increases expression

fipronil results in increased expression of CERT1 mRNA

NCBI chr 2:27,882,546...27,987,090
Ensembl chr 2:27,882,555...27,987,074

G

carboxylesterase 2C

increases expression

fipronil results in increased expression of CES2C mRNA

NCBI chr 1:260,391,190...260,398,757
Ensembl chr 1:260,388,902...260,398,790

G

carboxylesterase 2H

increases expression

fipronil results in increased expression of CES2H mRNA

NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830

G

cilia and flagella associated protein 36

increases expression

fipronil results in increased expression of CFAP36 mRNA

NCBI chr14:102,966,006...102,991,693
Ensembl chr14:102,966,001...102,991,555

G

coiled-coil-helix-coiled-coil-helix domain containing 6

increases expression

fipronil results in increased expression of CHCHD6 mRNA

NCBI chr 4:121,803,501...122,024,209
Ensembl chr 4:121,792,717...122,024,216

G

chromodomain helicase DNA binding protein 4

increases expression

fipronil results in increased expression of CHD4 mRNA

NCBI chr 4:157,898,503...157,931,632
Ensembl chr 4:157,899,391...157,931,541

G

chimerin 1

increases expression

fipronil results in increased expression of CHN1 mRNA

NCBI chr 3:58,509,822...58,676,462
Ensembl chr 3:58,510,536...58,676,490

G

chondrolectin

increases expression

fipronil results in increased expression of CHODL mRNA

NCBI chr11:17,654,137...17,676,450
Ensembl chr11:17,654,206...17,676,441

G

cholinergic receptor, muscarinic 3

increases expression

fipronil results in increased expression of CHRM3 mRNA

NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278

G

carbohydrate sulfotransferase 1

decreases expression

fipronil results in decreased expression of CHST1 mRNA

NCBI chr 3:78,552,059...78,574,740
Ensembl chr 3:78,548,525...78,574,883

G

chromatin target of PRMT1

increases expression

fipronil results in increased expression of CHTOP mRNA

NCBI chr 2:175,981,266...175,992,820
Ensembl chr 2:175,981,271...175,992,748

G

cell death-inducing DFFA-like effector a

increases expression

fipronil results in increased expression of CIDEA mRNA

NCBI chr18:60,894,917...60,920,485
Ensembl chr18:60,894,874...60,920,481

G

ciliary microtubule associated protein 1B

decreases expression

fipronil results in decreased expression of CIMAP1B mRNA

NCBI chr 7:120,444,232...120,447,294
Ensembl chr 7:120,444,232...120,446,749

G

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4

decreases expression

fipronil results in decreased expression of CITED4 mRNA

NCBI chr 5:134,246,936...134,247,827
Ensembl chr 5:134,246,682...134,248,135

G

CDC28 protein kinase regulatory subunit 1B

decreases expression

fipronil results in decreased expression of CKS1B mRNA

NCBI chr 2:174,833,025...174,837,614
Ensembl chr 2:174,833,050...174,837,636

G

cardiotrophin-like cytokine factor 1

increases expression

fipronil results in increased expression of CLCF1 mRNA

NCBI chr 1:201,507,763...201,517,607
Ensembl chr 1:201,507,859...201,517,605

G

claudin 9

increases expression

fipronil results in increased expression of CLDN9 mRNA

NCBI chr10:12,714,137...12,715,568

G

C-type lectin domain containing 14A

increases expression

fipronil results in increased expression of CLEC14A mRNA

NCBI chr 6:75,881,470...75,884,612
Ensembl chr 6:75,881,473...75,884,612

G

C-type lectin domain family 1, member B

increases expression

fipronil results in increased expression of CLEC1B mRNA

NCBI chr 4:162,847,978...162,856,291
Ensembl chr 4:162,848,010...162,856,291

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CAP-GLY domain containing linker protein 1

increases expression

fipronil results in increased expression of CLIP1 mRNA

NCBI chr12:32,910,932...33,017,891
Ensembl chr12:32,910,977...33,017,884

G