Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tideglusib
go back to main search page
Accession:CHEBI:147398 term browser browse the term
Definition:A member of the class of thiadiazolidines that is 1,2,4-thiadiazolidine-3,5-dione which is substituted by a naphthalen-1-yl group at position 2 and by a benzyl group at position 4. It is a non-ATP competitive inhibitor of glycogen synthase kinase 3beta (GSK3beta) and has neuroprotective effects. Currently under clinical investigation for the treatment of Alzheimer's disease and progressive supranuclear palsy.
Synonyms:exact_synonym: 4-benzyl-2-(naphthalen-1-yl)-1,2,4-thiadiazolidine-3,5-dione
 related_synonym: Formula=C19H14N2O2S;   InChI=1S/C19H14N2O2S/c22-18-20(13-14-7-2-1-3-8-14)19(23)24-21(18)17-12-6-10-15-9-4-5-11-16(15)17/h1-12H,13H2;   InChIKey=PMJIHLSCWIDGMD-UHFFFAOYSA-N;   NP-031112;   NP-12;   NP031112;   Nypta;   SMILES=O=C1N(C=2C3=C(C=CC=C3)C=CC2)SC(=O)N1CC4=CC=CC=C4;   Zentylor;   tideglusibum
 xref: CAS:865854-05-3;   DrugBank:DB12129
 xref_mesh: MESH:C520571
 xref: PMID:17522320;   PMID:22936007;   PMID:24488721;   PMID:24532007;   PMID:25537011;   PMID:26289787;   PMID:26398371;   PMID:27378458;   PMID:27490211;   PMID:28982059;   PMID:29388174;   PMID:29431064;   PMID:29603837;   PMID:30574063;   PMID:30666199;   PMID:30965670;   PMID:31156177;   PMID:32195836;   Wikipedia:Tideglusib


show annotations for term's descendants           Sort by:
tideglusib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsk3b glycogen synthase kinase 3 beta increases expression
decreases activity		 ISO tideglusib results in increased expression of GSK3B protein modified form
tideglusib results in decreased activity of GSK3B protein		 CTD PMID:30965670 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO NFE2L2 protein promotes the reaction [tideglusib inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of HMOX1 mRNA]]; tideglusib inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of HMOX1 mRNA]; tideglusib inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA] CTD PMID:30965670 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO NFE2L2 protein promotes the reaction [tideglusib inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of HMOX1 mRNA]]; NFE2L2 protein promotes the reaction [tideglusib inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of NQO1 mRNA]]; NFE2L2 protein promotes the reaction [tideglusib inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of NQO1 protein]]; tideglusib inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NFE2L2 mRNA]; tideglusib promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NFE2L2 mRNA] CTD PMID:30965670 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO NFE2L2 protein promotes the reaction [tideglusib inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of NQO1 mRNA]]; NFE2L2 protein promotes the reaction [tideglusib inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of NQO1 protein]]; tideglusib inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of NQO1 mRNA]; tideglusib inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of NQO1 protein]; tideglusib inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NQO1 mRNA] CTD PMID:30965670 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO tideglusib inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of PPARG protein] CTD PMID:30965670 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      application 19695
        anti-inflammatory agent 16672
          tideglusib 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            organic molecule 19706
                              organic cyclic compound 19495
                                carbocyclic compound 18584
                                  carbopolycyclic compound 17183
                                    carbobicyclic compound 5884
                                      naphthalenes 3849
                                        tideglusib 5
paths to the root