oneirogen - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	oneirogen	go back to main search page
Accession:	CHEBI:146270	browse the term
Definition:	Any substance that produces or enhances dream-like states of consciousness.
Synonyms:	related_synonym:	oneirogens
	xref:	wikipedia.en:Oneirogen

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Rat (525 ) Mouse (533 ) Human (530 ) Chinchilla (0 ) Bonobo (0 ) Dog (4 ) Squirrel (0 ) Pig (0 ) Green Monkey (0) Naked Mole-rat (0 ) All
Genes (525)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

multiple interactions
decreases activity

ISO

Atropine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Atropine results in decreased activity of ABCB11 protein

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

multiple interactions

ISO

[Parathion co-treated with Atropine] results in increased expression of ABL1 mRNA

NCBI chr 3:35,377,587...35,480,843
Ensembl chr 3:35,377,391...35,480,846

G

acetylcholinesterase

multiple interactions

ISO
EXP

Atropine inhibits the reaction [[Organophosphorus Compounds results in decreased activity of ACHE protein] which results in increased abundance of Acetylcholine]; Atropine inhibits the reaction [Carbachol results in increased metabolism of and results in increased secretion of ACHE protein]; Atropine inhibits the reaction [Paraoxon results in increased expression of ACHE protein]
[Atropine co-treated with Obidoxime Chloride] inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; [Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of ACHE protein; [Paraoxon co-treated with pralidoxime co-treated with Atropine] results in decreased activity of ACHE protein; [pralidoxime co-treated with Atropine] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; [tariquidar co-treated with asoxime chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein]; Atropine inhibits the reaction [Methyl Parathion results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [[Paraoxon co-treated with pralidoxime co-treated with Atropine] results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [[Atropine co-treated with Curcumin] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]]
[1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; [[1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide co-treated with cucurbit(7)uril] co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; Atropine inhibits the reaction [Sarin results in decreased activity of ACHE protein]; Atropine promotes the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]; Atropine promotes the reaction [haloxon results in increased phosphorylation of ACHE protein]; Atropine promotes the reaction [Paraoxon results in increased phosphorylation of ACHE protein]

PMID:2241428 PMID:10421444 PMID:17963125 PMID:20105433 PMID:21600273 More...

NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410

G

adenylate cyclase 5

increases response to substance

ISO

ADCY5 protein results in increased susceptibility to Atropine

NCBI chr11:78,976,861...79,123,343
Ensembl chr11:78,976,861...79,123,343

G

albumin

multiple interactions

EXP

Atropine inhibits the reaction [Dichlorvos results in decreased expression of ALB protein]

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865

G

aquaporin 5

multiple interactions

ISO

Atropine inhibits the reaction [Pilocarpine affects the localization of AQP5 protein]

NCBI chr 7:132,601,528...132,605,060
Ensembl chr 7:132,601,059...132,605,062

G

BCL2 associated X, apoptosis regulator

multiple interactions

EXP

[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the expression of BAX mRNA]

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCAR1 scaffold protein, Cas family member

multiple interactions

ISO

Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of BCAR1 protein]]

NCBI chr19:56,588,500...56,623,190
Ensembl chr19:56,588,500...56,623,190

G

butyrylcholinesterase

multiple interactions

EXP
ISO

[Atropine co-treated with pralidoxime] results in decreased expression of BCHE protein; [Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of BCHE protein
[BCHE protein co-treated with asoxime chloride co-treated with pro-diazepam co-treated with Atropine] results in decreased susceptibility to VX-agent

PMID:17963125 PMID:22981459

NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760

G

bradykinin receptor B2

multiple interactions

ISO

BDKRB2 affects the susceptibility to [Propranolol co-treated with Atropine]

NCBI chr 6:130,237,055...130,267,205
Ensembl chr 6:130,237,255...130,267,209

G

bone morphogenetic protein 6

multiple interactions

EXP

Atropine inhibits the reaction [Carbon Tetrachloride results in increased expression of BMP6 mRNA]

NCBI chr17:26,523,704...26,785,558
Ensembl chr17:26,523,704...26,675,261

G

calcium voltage-gated channel subunit alpha1 E

multiple interactions

EXP

Atropine inhibits the reaction [Methacholine Chloride affects the reaction [CACNA1E protein results in increased transport of Barium]]

NCBI chr13:69,125,048...69,613,795
Ensembl chr13:69,132,305...69,612,983

G

calcitonin-related polypeptide alpha

affects activity

EXP

Atropine affects the activity of CALCA protein

PMID:7906887 PMID:10075105

NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:178,312,638...178,317,529

G

caspase 3

increases expression
multiple interactions

EXP

Atropine results in increased expression of CASP3 mRNA
Atropine inhibits the reaction [Dichlorvos results in increased expression of CASP3 mRNA]

PMID:19815060 PMID:39733793

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

C-C motif chemokine ligand 5

multiple interactions

ISO

[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CCL5 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CCL5 protein]

NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884

G

cyclin A1

increases expression
multiple interactions

ISO

Atropine results in increased expression of CCNA1 mRNA
[Parathion co-treated with Atropine] results in increased expression of CCNA1 mRNA

NCBI chr 2:141,383,352...141,428,205
Ensembl chr 2:141,382,468...141,393,300

G

cyclin D3

multiple interactions

ISO

[Parathion co-treated with Atropine] results in increased expression of CCND3 mRNA

NCBI chr 9:20,891,696...20,987,199
Ensembl chr 9:20,891,704...20,987,033

G

cyclin E1

increases expression
multiple interactions

ISO

Atropine results in increased expression of CCNE1 mRNA
[Parathion co-treated with Atropine] results in increased expression of CCNE1 mRNA

NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:99,918,674...99,927,822

G

cyclin E2

multiple interactions
increases expression

ISO

[Parathion co-treated with Atropine] results in increased expression of CCNE2 mRNA
Atropine results in increased expression of CCNE2 mRNA

NCBI chr 5:29,082,169...29,094,879
Ensembl chr 5:29,082,703...29,094,882

G

CD40 molecule

multiple interactions

ISO

Atropine inhibits the reaction [Carbachol results in increased expression of CD40 protein]

NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:174,209,719...174,224,847

G

cell division cycle 20

multiple interactions
increases expression

ISO

[Parathion co-treated with Atropine] results in increased expression of CDC20 mRNA
Atropine results in increased expression of CDC20 mRNA

NCBI chr 5:137,251,596...137,255,799
Ensembl chr 5:137,251,596...137,255,799

G

cell division cycle 6

multiple interactions

ISO

[Parathion co-treated with Atropine] results in increased expression of CDC6 mRNA

NCBI chr10:84,360,361...84,374,239
Ensembl chr10:84,360,381...84,374,241

G

cyclin-dependent kinase 1

multiple interactions
increases expression

ISO

[Parathion co-treated with Atropine] results in increased expression of CDK1 mRNA
Atropine results in increased expression of CDK1 mRNA

NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455

G

carboxylesterase 1D

multiple interactions

ISO

Atropine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate]

NCBI chr19:30,046,494...30,085,039
Ensembl chr19:30,046,449...30,085,449

G

cholinergic receptor, muscarinic 1

multiple interactions
decreases activity

ISO

Atropine binds to and results in decreased activity of CHRM1 protein; Atropine inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]
Atropine results in decreased activity of CHRM1 protein
Atropine affects the reaction [muscarinic toxin 7 binds to CHRM1 protein]

PMID:16439611 PMID:18316702 PMID:31830555

NCBI chr 1:214,996,180...215,012,136
Ensembl chr 1:214,995,872...215,020,602

G

cholinergic receptor, muscarinic 2

multiple interactions

ISO

Atropine binds to and results in decreased activity of CHRM2 protein

NCBI chr 4:65,981,136...66,116,128
Ensembl chr 4:65,981,006...66,126,464

G

cholinergic receptor, muscarinic 3

multiple interactions
decreases activity

ISO

Atropine binds to and results in decreased activity of CHRM3 protein; Atropine inhibits the reaction [Carbachol results in increased activity of CHRM3 protein]
Atropine results in decreased activity of CHRM3 protein

PMID:15140916 PMID:20708676 PMID:31830555

NCBI chr17:64,696,549...65,158,622
Ensembl chr17:64,696,066...65,173,304

G

cholinergic receptor, muscarinic 4

multiple interactions
affects binding

ISO

[WIN 62577 co-treated with Quinuclidinyl Benzilate] inhibits the reaction [Atropine binds to CHRM4 protein]

NCBI chr 3:98,349,080...98,356,821
Ensembl chr 3:98,348,650...98,358,771

G

cholinergic receptor, muscarinic 5

multiple interactions

ISO

Atropine inhibits the reaction [Acetylcholine results in increased activity of CHRM5 protein]

NCBI chr 3:119,739,229...119,791,630
Ensembl chr 3:119,735,975...119,792,166

G

cholinergic receptor nicotinic alpha 4 subunit

multiple interactions
affects binding

ISO
EXP

Atropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]
Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 mRNA]]; Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 protein]]
Atropine binds to [CHRNA4 protein binds to CHRNB2 protein]

PMID:15733544 PMID:21791372

NCBI chr 3:188,506,802...188,535,558
Ensembl chr 3:188,501,209...188,535,105

G

cholinergic receptor nicotinic beta 2 subunit

affects binding
multiple interactions

ISO
EXP

Atropine binds to [CHRNA4 protein binds to CHRNB2 protein]
Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 mRNA]]; Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 protein]]
Atropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]

PMID:15733544 PMID:21791372

NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:177,479,091...177,491,326

G

cAMP responsive element binding protein 1

multiple interactions

EXP

[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of CREB1 protein]

NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339

G

corticotropin releasing hormone

multiple interactions

EXP
ISO

Atropine inhibits the reaction [acephate results in increased expression of CRH mRNA]; Atropine inhibits the reaction [acephate results in increased secretion of CRH protein]; Atropine inhibits the reaction [methamidophos results in increased expression of CRH mRNA]; Atropine inhibits the reaction [methamidophos results in increased secretion of CRH protein]
[Atropine co-treated with SR 140333 co-treated with SR 48968] results in decreased activity of CRH protein

PMID:12039681 PMID:12906840

NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:104,058,770...104,061,386

G

catenin beta 1

multiple interactions

ISO

Atropine inhibits the reaction [Parathion results in increased expression of CTNNB1 protein mutant form]; Atropine inhibits the reaction [Parathion results in increased expression of CTNNB1 protein]

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662

G

C-X-C motif chemokine ligand 3

multiple interactions

ISO

[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CXCL1 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CXCL1 protein]

NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624

G

dishevelled segment polarity protein 2

multiple interactions

ISO

Atropine inhibits the reaction [Parathion results in increased expression of DVL2 protein]

NCBI chr10:55,222,245...55,231,506
Ensembl chr10:55,222,056...55,231,506

G

endothelin 1

multiple interactions

ISO

EDN1 protein results in decreased activity of [Atropine co-treated with Histamine]

NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687

G

eukaryotic translation elongation factor 2

multiple interactions

ISO

atropine inhibits the reaction [carbachol decreases phosphorylation of EEF2 protein in colon cancer cells]

RGD

NCBI chr 7:9,183,836...9,196,255
Ensembl chr 7:9,183,961...9,189,544

G

epidermal growth factor receptor

multiple interactions

ISO

Atropine inhibits the reaction [Parathion results in increased expression of EGFR protein]

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358

G

early growth response 1

multiple interactions

EXP

Atropine inhibits the reaction [Pilocarpine results in increased expression of EGR1 mRNA]

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843

G

early growth response 2

multiple interactions

EXP

Atropine inhibits the reaction [Pilocarpine results in increased expression of EGR2 mRNA]

NCBI chr20:21,050,149...21,055,201
Ensembl chr20:21,050,149...21,057,748

G

ezrin

multiple interactions

ISO

Atropine inhibits the reaction [Parathion results in increased expression of EZR protein]

NCBI chr 1:49,373,033...49,416,573
Ensembl chr 1:49,373,035...49,416,573

G

coagulation factor II, thrombin

multiple interactions

ISO

[Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in decreased expression of F2 mRNA; [Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in increased activity of F2 protein

NCBI chr 3:98,051,958...98,065,246
Ensembl chr 3:98,051,960...98,065,246

G

coagulation factor II (thrombin) receptor

multiple interactions

ISO

[Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in increased expression of F2R protein

NCBI chr 2:28,604,066...28,620,579
Ensembl chr 2:28,604,066...28,620,579

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression
multiple interactions

EXP
ISO

Atropine results in increased expression of FOS protein
Atropine inhibits the reaction [Paraoxon results in increased expression of FOS mRNA]
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased expression of FOS protein]; Atropine inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA]

PMID:7968354 PMID:8281324 PMID:21787676 PMID:21971501

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

ghrelin and obestatin prepropeptide

multiple interactions

EXP

Atropine inhibits the reaction [[Pentobarbital co-treated with L-pyroglutamyl-L-histidyl-3,3-dimethylprolinamide] results in increased expression of GHRL protein]

NCBI chr 4:148,421,315...148,431,128
Ensembl chr 4:148,421,315...148,425,969

G

glycine receptor, alpha 1

multiple interactions

ISO

Atropine binds to and results in decreased activity of GLRA1 protein

NCBI chr10:40,128,284...40,228,612
Ensembl chr10:40,130,121...40,227,815

G

glutamic--pyruvic transaminase

multiple interactions

EXP

Atropine inhibits the reaction [Dichlorvos results in increased activity of GPT protein]

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

glutamate metabotropic receptor 4

multiple interactions

ISO

Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]

NCBI chr20:5,486,024...5,574,668
Ensembl chr20:5,482,977...5,574,668

G

3-hydroxy-3-methylglutaryl-CoA reductase

multiple interactions

EXP

Atropine inhibits the reaction [Dichlorvos results in decreased activity of HMGCR protein]

NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533

G

intercellular adhesion molecule 1

multiple interactions

ISO

[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of ICAM1 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of ICAM1 protein]

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617

G

interleukin 10

multiple interactions

EXP

Atropine inhibits the reaction [Dichlorvos results in decreased expression of IL10 mRNA]

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 1 beta

multiple interactions

ISO

[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of IL1B mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of IL1B protein]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

multiple interactions

ISO

[Atropine co-treated with Ketamine] inhibits the reaction [Soman results in increased expression of IL6 mRNA]; [Atropine co-treated with Ketamine] inhibits the reaction [Soman results in increased expression of IL6 protein]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

EXP

[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of JUN protein]

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

JunB proto-oncogene, AP-1 transcription factor subunit

multiple interactions

EXP

Atropine inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA]

NCBI chr19:40,081,126...40,082,910
Ensembl chr19:40,073,541...40,085,218

G

potassium inwardly-rectifying channel, subfamily J, member 3

multiple interactions

ISO

Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]

NCBI chr 3:60,353,990...60,518,110
Ensembl chr 3:60,354,146...60,518,104

G

KIT proto-oncogene receptor tyrosine kinase

multiple interactions

ISO

Atropine inhibits the reaction [Parathion results in increased expression of KIT protein]

NCBI chr14:32,901,615...32,978,895
Ensembl chr14:32,903,033...32,978,812

G

lactotransferrin

multiple interactions

ISO

Atropine inhibits the reaction [methylcholine results in increased secretion of LTF protein]

NCBI chr 8:119,878,344...119,901,189
Ensembl chr 8:119,878,344...119,901,189

G

mitogen activated protein kinase 1

multiple interactions

EXP

[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK1 protein]

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 14

multiple interactions

EXP

[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK14 protein]

NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294

G

mitogen activated protein kinase 3

multiple interactions

EXP

[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 8

multiple interactions

EXP

[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

minichromosome maintenance complex component 4

multiple interactions
increases expression

ISO

[Parathion co-treated with Atropine] results in increased expression of MCM4 mRNA
Atropine results in increased expression of MCM4 mRNA

NCBI chr11:98,762,599...98,776,300
Ensembl chr11:98,762,634...98,776,536

G

minichromosome maintenance complex component 6

increases expression
multiple interactions

ISO

Atropine results in increased expression of MCM6 mRNA
[Parathion co-treated with Atropine] results in increased expression of MCM6 mRNA

NCBI chr13:42,379,161...42,404,352
Ensembl chr13:42,379,162...42,465,467

G

neurofilament heavy chain

affects expression

EXP

Atropine affects the expression of NEFH mRNA

NCBI chr14:84,044,428...84,054,413
Ensembl chr14:84,044,023...84,054,417

G

NLR family, pyrin domain containing 3

increases expression

ISO

Atropine results in increased expression of NLRP3 mRNA

NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394

G

nitric oxide synthase 2

multiple interactions

EXP

Atropine inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]; Atropine inhibits the reaction [Indomethacin results in increased expression of NOS2 mRNA]

PMID:15610444 PMID:16944022

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

notch receptor 4

multiple interactions

ISO

Atropine inhibits the reaction [Parathion results in increased expression of NOTCH4 protein]

NCBI chr20:4,164,969...4,189,072
Ensembl chr20:4,161,730...4,189,072

G

natriuretic peptide A

affects activity

EXP

Atropine affects the activity of NPPA protein modified form

NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:163,712,184...163,713,493

G

opioid related nociceptin receptor 1

multiple interactions

EXP

Atropine inhibits the reaction [PNOC protein binds to and results in increased activity of OPRL1 protein]

NCBI chr 3:189,209,495...189,225,406
Ensembl chr 3:189,212,175...189,217,426

G

proliferating cell nuclear antigen

multiple interactions

ISO

Atropine inhibits the reaction [Malathion results in increased expression of PCNA]; Atropine inhibits the reaction [Parathion results in increased expression of PCNA]

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901

G

prepronociceptin

multiple interactions

EXP

Atropine inhibits the reaction [PNOC protein binds to and results in increased activity of OPRL1 protein]

NCBI chr15:43,800,240...43,827,841
Ensembl chr15:43,800,246...43,827,470

G

proopiomelanocortin

multiple interactions

EXP

Atropine inhibits the reaction [Acetylcholine results in increased expression of POMC protein]

NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:32,659,346...32,665,173

G

peroxisome proliferator activated receptor alpha

multiple interactions

ISO

[Atropine co-treated with Glucose] binds to PPARA protein; Atropine inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]

NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714

G

prostaglandin-endoperoxide synthase 2

multiple interactions

EXP

Atropine affects the reaction [Indomethacin results in increased expression of PTGS2]; Atropine inhibits the reaction [Indomethacin results in increased expression of PTGS2 mRNA]; Atropine inhibits the reaction [Indomethacin results in increased expression of PTGS2]; Atropine inhibits the reaction [SC 560 results in increased expression of PTGS2 mRNA]

PMID:15104355 PMID:15610444 PMID:16259740 PMID:16804302

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

protein tyrosine kinase 2

multiple interactions

ISO

Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein]]; Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein]]; Atropine inhibits the reaction [oxotremorine M promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with wortmannin] results in increased phosphorylation of PTK2 protein]]

NCBI chr 7:107,015,730...107,220,865
Ensembl chr 7:107,015,733...107,172,091

G

paxillin

multiple interactions

ISO

Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of PXN protein]]

NCBI chr12:46,721,546...46,768,706
Ensembl chr12:46,721,546...46,768,697

G

Rac family small GTPase 3

multiple interactions

ISO

Atropine inhibits the reaction [Parathion results in increased expression of RAC3 protein]

NCBI chr10:106,501,133...106,503,569
Ensembl chr10:106,501,135...106,503,569

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

EXP

[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of RELA protein]; Atropine inhibits the reaction [Dichlorvos results in increased expression of RELA mRNA]

PMID:21971501 PMID:39733793

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

ras homolog family member A

multiple interactions

ISO

Atropine inhibits the reaction [Parathion results in increased expression of RHOA protein]

NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:117,870,270...117,904,302

G

solute carrier family 22 member 1

multiple interactions

ISO

Atropine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Atropine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

PMID:16263091 PMID:21641380

NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:50,624,377...50,651,436

G

solute carrier family 22 member 2

multiple interactions

ISO

Atropine inhibits the reaction [SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Atropine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Atropine inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]

PMID:16263091 PMID:21599003 PMID:23770354

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

G

solute carrier family 22 member 3

increases uptake
multiple interactions

ISO

SLC22A3 protein results in increased uptake of Atropine
Atropine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]

NCBI chr 1:50,783,218...50,872,358
Ensembl chr 1:50,783,218...50,872,353

G

solute carrier family 22 member 4

multiple interactions

ISO

Atropine inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]

NCBI chr10:38,634,098...38,687,409
Ensembl chr10:38,634,098...38,679,920

G

solute carrier family 47 member 1

multiple interactions

ISO

Atropine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:46,533,580...46,590,128
Ensembl chr10:46,533,583...46,587,096

G

solute carrier family 47 member 2

multiple interactions

ISO

Atropine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:46,490,262...46,532,954
Ensembl chr10:46,489,831...46,533,425

G

secretory leukocyte peptidase inhibitor

increases expression

ISO

Atropine results in increased expression of SLPI mRNA

NCBI chr 3:173,501,573...173,503,822
Ensembl chr 3:173,501,573...173,503,822

G

suppressor of cytokine signaling 3

multiple interactions

ISO

[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of SOCS3 mRNA]

NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,690,976...103,704,825

G

sialophorin

increases response to substance

ISO

SPN protein results in increased susceptibility to Atropine

NCBI chr 1:191,177,449...191,190,115
Ensembl chr 1:191,178,096...191,187,852

G

tyrosine aminotransferase

multiple interactions

EXP

[Atropine co-treated with Obidoxime Chloride co-treated with Diazepam] inhibits the reaction [Dichlorvos results in increased expression of TAT protein]

NCBI chr19:54,856,604...54,867,168
Ensembl chr19:54,856,563...54,867,482

G

transforming growth factor, beta 1

multiple interactions

EXP

Atropine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

tumor necrosis factor

multiple interactions

ISO

[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of TNF mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of TNF protein]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

tumor protein p53

multiple interactions

ISO

Atropine inhibits the reaction [Malathion results in increased expression of TP53 protein]; Atropine inhibits the reaction [Parathion results in increased expression of TP53 protein]

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

trio Rho guanine nucleotide exchange factor

multiple interactions

ISO

Atropine inhibits the reaction [Parathion results in increased expression of TRIO protein]

NCBI chr 2:80,235,485...80,531,824
Ensembl chr 2:80,235,485...80,531,612

G

transient receptor potential cation channel, subfamily A, member 1

decreases response to substance

ISO

TRPA1 gene mutant form results in decreased susceptibility to Atropine

NCBI chr 5:9,163,060...9,217,325
Ensembl chr 5:9,163,060...9,217,325

G

thyroid stimulating hormone subunit beta

multiple interactions

EXP

[pralidoxime co-treated with Atropine] inhibits the reaction [methamidophos results in decreased expression of TSHB protein]

NCBI chr 2:192,913,171...192,918,054
Ensembl chr 2:192,913,171...192,942,984

G

translocator protein

multiple interactions

EXP

[Ketamine co-treated with Midazolam co-treated with Valproic Acid] inhibits the reaction [[Sarin co-treated with [Atropine co-treated with trimethylene-bis(4-hydroxyiminomethylpyridinium)]] results in increased expression of TSPO protein]; [Sarin co-treated with [Atropine co-treated with trimethylene-bis(4-hydroxyiminomethylpyridinium)]] results in increased expression of TSPO protein

NCBI chr 7:116,600,214...116,610,461
Ensembl chr 7:116,600,210...116,610,460

G

vascular cell adhesion molecule 1

multiple interactions

ISO

[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of VCAM1 mRNA]

NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 4

decreases activity

ISO

Benztropine results in decreased activity of ABCB4 protein

NCBI chr 4:26,106,895...26,164,440

G

acyl-CoA thioesterase 2

increases expression

ISO

Benztropine results in increased expression of ACOT2 protein

NCBI chr 6:109,341,426...109,352,818
Ensembl chr 6:109,342,646...109,350,502

G

actin, beta-like 2

increases expression

ISO

Benztropine results in increased expression of ACTBL2 protein

NCBI chr 2:44,591,391...44,594,138
Ensembl chr 2:44,591,391...44,594,138

G

actin related protein 1A

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of ACTR1A protein

NCBI chr 1:255,179,241...255,199,009
Ensembl chr 1:255,179,242...255,199,459

G

actin related protein 3

decreases expression

ISO

Benztropine results in decreased expression of ACTR3 protein

NCBI chr13:39,353,413...39,396,509
Ensembl chr13:39,353,079...39,396,711

G

adenylosuccinate lyase

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of ADSL protein

NCBI chr 7:114,359,440...114,383,618
Ensembl chr 7:114,359,440...114,384,872

G

alkylglycerone phosphate synthase

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of AGPS protein

NCBI chr 3:81,154,599...81,253,099
Ensembl chr 3:81,154,604...81,258,277

G

adenylate kinase 1

decreases expression

ISO

Benztropine results in decreased expression of AK1 protein

NCBI chr 3:36,310,113...36,320,760
Ensembl chr 3:36,310,197...36,320,757

G

annexin A1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of ANXA1 protein

NCBI chr 1:227,287,713...227,306,739
Ensembl chr 1:227,287,717...227,306,831

G

annexin A5

decreases expression

ISO

Benztropine results in decreased expression of ANXA5 protein

NCBI chr 2:121,242,133...121,272,935
Ensembl chr 2:121,242,136...121,281,400

G

annexin A6

decreases expression

ISO

Benztropine results in decreased expression of ANXA6 protein

NCBI chr10:39,602,106...39,657,183
Ensembl chr10:39,602,106...39,657,359

G

annexin A7

increases expression

ISO

Benztropine results in increased expression of ANXA7 protein

NCBI chr15:3,869,180...3,897,827
Ensembl chr15:3,870,974...3,898,891

G

acidic residue methyltransferase 1

increases expression

ISO

Benztropine results in increased expression of DCPH1 protein

NCBI chr 1:43,299,916...43,323,675
Ensembl chr 1:43,299,826...43,323,670

G

asparagine synthetase (glutamine-hydrolyzing)

decreases expression

ISO

Benztropine results in decreased expression of ASNS protein

NCBI chr 4:36,752,061...36,769,970
Ensembl chr 4:36,751,802...36,776,050

G

aspartate-beta-hydroxylase

increases expression

ISO

Benztropine results in increased expression of ASPH protein

NCBI chr 5:27,398,933...27,611,519
Ensembl chr 5:27,398,949...27,611,215

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3

increases expression

ISO

Benztropine results in increased expression of ATP2A3 protein

NCBI chr10:58,079,710...58,111,279
Ensembl chr10:58,079,852...58,111,278

G

ATP synthase F1 subunit gamma

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of ATP5F1C protein

NCBI chr17:73,333,584...73,355,872
Ensembl chr17:73,333,588...73,383,073

G

ATPase H+ transporting V1 subunit B2

decreases expression

ISO

Benztropine results in decreased expression of ATP6V1B2 protein

NCBI chr16:25,384,254...25,408,388
Ensembl chr16:25,384,257...25,408,839

G

ataxin 10

increases expression

ISO

Benztropine results in increased expression of ATXN10 protein

NCBI chr 7:118,321,516...118,444,967
Ensembl chr 7:118,319,490...118,445,636

G

bromodomain adjacent to zinc finger domain, 1B

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of BAZ1B protein

NCBI chr12:27,068,541...27,126,511
Ensembl chr12:27,068,541...27,126,511

G

BCAR1 scaffold protein, Cas family member

decreases expression

ISO

Benztropine results in decreased expression of BCAR1 protein

NCBI chr19:56,588,500...56,623,190
Ensembl chr19:56,588,500...56,623,190

G

bridge-like lipid transfer protein family member 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of BLTP1 protein

NCBI chr 2:121,636,181...121,852,802
Ensembl chr 2:121,636,323...121,852,802

G

bone morphogenetic protein 6

increases expression

ISO

Benztropine results in increased expression of BMP6 mRNA

NCBI chr17:26,523,704...26,785,558
Ensembl chr17:26,523,704...26,675,261

G

bromodomain containing 2

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of BRD2 protein

NCBI chr20:4,728,282...4,737,286
Ensembl chr20:4,728,951...4,737,290

G

basigin

decreases expression

ISO

Benztropine results in decreased expression of BSG protein

NCBI chr 7:10,643,788...10,651,005
Ensembl chr 7:10,643,789...10,651,005

G

caldesmon 1

decreases expression
multiple interactions

ISO

Benztropine results in decreased expression of CALD1 protein
[Cuprizone co-treated with Benztropine] results in decreased expression of CALD1 protein

NCBI chr 4:64,232,906...64,414,085
Ensembl chr 4:64,233,171...64,414,085

G

calumenin

decreases expression

ISO

Benztropine results in decreased expression of CALU protein

NCBI chr 4:58,914,456...58,941,957
Ensembl chr 4:58,914,421...58,941,956

G

calcium/calmodulin-dependent protein kinase II delta

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of CAMK2D protein

NCBI chr 2:217,698,324...217,961,898
Ensembl chr 2:217,698,551...217,960,276

G

cell cycle associated protein 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of CAPRIN1 protein

NCBI chr 3:110,606,489...110,685,408
Ensembl chr 3:110,606,489...110,685,562

G

caspase 8 associated protein 2

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of CASP8AP2 protein

NCBI chr 5:51,809,366...51,848,633
Ensembl chr 5:51,810,972...51,848,632

G

chromobox 5

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of CBX5 protein

NCBI chr 7:136,203,827...136,254,575
Ensembl chr 7:136,211,649...136,229,118

G

cell division cycle and apoptosis regulator 1

increases expression

ISO

Benztropine results in increased expression of CCAR1 protein

NCBI chr20:31,228,624...31,271,233
Ensembl chr20:31,228,624...31,271,227

G

coiled-coil domain containing 121

increases expression

ISO

Benztropine results in increased expression of CCDC121 protein

NCBI chr 6:30,690,831...30,693,437
Ensembl chr 6:30,690,831...30,693,437

G

chaperonin containing TCP1 subunit 6A

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of CCT6A protein

NCBI chr12:32,508,842...32,519,072
Ensembl chr12:32,508,675...32,519,119

G

chaperonin containing TCP1 subunit 7

decreases expression

ISO

Benztropine results in decreased expression of CCT7 protein

NCBI chr 4:119,546,730...119,563,973
Ensembl chr 4:119,546,730...119,563,973

G

chaperonin containing TCP1 subunit 8

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of CCT8 protein

NCBI chr11:40,196,619...40,208,328
Ensembl chr11:40,196,619...40,208,328

G

Cd276 molecule

decreases expression

ISO

Benztropine results in decreased expression of CD276 protein

NCBI chr 8:67,833,587...67,863,918
Ensembl chr 8:67,829,048...67,864,505

G

centromere protein V

increases expression

ISO

Benztropine results in increased expression of CENPV protein

NCBI chr10:47,713,778...47,746,800
Ensembl chr10:47,713,778...47,727,679

G

chromodomain helicase DNA binding protein 4

decreases expression

ISO

Benztropine results in decreased expression of CHD4 protein

NCBI chr 4:159,584,623...159,617,867
Ensembl chr 4:159,584,654...159,617,866

G

creatine kinase B

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of CKB protein

NCBI chr 6:136,550,583...136,553,464
Ensembl chr 6:136,549,844...136,553,478

G

2',3'-cyclic nucleotide 3' phosphodiesterase

multiple interactions
decreases expression

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of CNP protein
Benztropine results in decreased expression of CNP protein

NCBI chr10:86,011,504...86,018,063
Ensembl chr10:86,011,495...86,018,063

G

collagen type XIV alpha 1 chain

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of COL14A1 protein

NCBI chr 7:88,611,827...88,826,939
Ensembl chr 7:88,611,828...88,826,938

G

collagen type V alpha 2 chain

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of COL5A2 protein

NCBI chr 9:54,940,768...55,090,151
Ensembl chr 9:54,940,764...55,090,150

G

COP9 signalosome subunit 4

decreases expression

ISO

Benztropine results in decreased expression of COPS4 protein

NCBI chr14:9,382,897...9,413,216
Ensembl chr14:9,382,900...9,413,107

G

coronin 1B

decreases expression

ISO

Benztropine results in decreased expression of CORO1B protein

NCBI chr 1:210,872,437...210,877,876
Ensembl chr 1:210,871,841...210,877,876

G

coronin 7

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of CORO7 protein

NCBI chr10:11,386,683...11,447,422
Ensembl chr10:11,391,613...11,447,866

G

copine 3

decreases expression

ISO

Benztropine results in decreased expression of CPNE3 protein

NCBI chr 5:37,811,566...37,860,840
Ensembl chr 5:37,811,566...37,861,062

G

cleavage and polyadenylation specific factor 3

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of CPSF3 protein

NCBI chr 6:46,564,855...46,592,776
Ensembl chr 6:46,564,735...46,594,136

G

cartilage associated protein

increases expression

ISO

Benztropine results in increased expression of CRTAP protein

NCBI chr 8:122,926,117...122,945,843
Ensembl chr 8:122,926,117...122,945,843

G

crystallin zeta

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of CRYZ protein

NCBI chr 2:246,211,707...246,239,472
Ensembl chr 2:246,211,156...246,239,470

G

cold shock domain containing E1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of CSDE1 protein

NCBI chr 2:193,234,546...193,271,301
Ensembl chr 2:193,243,526...193,271,301

G

cleavage stimulation factor subunit 2

decreases expression

ISO

Benztropine results in decreased expression of CSTF2 protein

NCBI chr X:101,546,809...101,572,760
Ensembl chr X:101,546,819...101,572,764

G

C-terminal binding protein 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of CTBP1 protein

NCBI chr14:81,679,956...81,707,331
Ensembl chr14:81,679,765...81,707,554

G

cullin 2

increases expression

ISO

Benztropine results in increased expression of CUL2 protein

NCBI chr17:58,864,274...58,905,447
Ensembl chr17:58,864,274...58,905,132

G

cullin 4B

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of CUL4B protein

NCBI chr X:122,154,332...122,192,299
Ensembl chr X:122,154,332...122,192,299

G

aspartyl-tRNA synthetase 2 (mitochondrial)

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of DARS2 protein

NCBI chr13:75,842,078...75,870,319
Ensembl chr13:75,836,565...75,869,904

G

DAZ associated protein 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of DAZAP1 protein

NCBI chr 7:10,074,342...10,098,810
Ensembl chr 7:10,074,849...10,095,599

G

dynactin subunit 2

increases expression

ISO

Benztropine results in increased expression of DCTN2 protein

NCBI chr 7:64,977,338...64,992,875
Ensembl chr 7:64,977,363...64,992,873

G

DEAD-box helicase 17

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of DDX17 protein

NCBI chr 7:112,971,522...112,989,747
Ensembl chr 7:112,971,523...112,989,747

G

DEAD-box helicase 3, X-linked

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of DDX3X protein

NCBI chr X:12,152,346...12,165,983
Ensembl chr X:12,152,346...12,165,983

G

DiGeorge syndrome critical region gene 6

decreases expression

ISO

Benztropine results in decreased expression of DGCR6 protein

NCBI chr11:96,432,024...96,442,766
Ensembl chr11:96,432,024...96,437,255

G

24-dehydrocholesterol reductase

increases expression

ISO

Benztropine results in increased expression of DHCR24 protein

NCBI chr 5:126,573,366...126,599,940
Ensembl chr 5:126,573,338...126,599,936

G

DEAH-box helicase 8

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of DHX8 protein

NCBI chr10:87,167,861...87,204,426
Ensembl chr10:87,168,062...87,205,875

G

dihydrolipoamide S-acetyltransferase

multiple interactions
increases expression

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of DLAT protein
Benztropine results in increased expression of DLAT protein

NCBI chr 8:59,875,537...59,900,947
Ensembl chr 8:59,868,214...59,900,818
Ensembl chr 1:59,868,214...59,900,818

G

discs large MAGUK scaffold protein 2

increases expression

ISO

Benztropine results in increased expression of DLG2 protein

NCBI chr 1:153,864,545...155,916,238
Ensembl chr 1:153,865,299...155,916,215

G

DnaJ heat shock protein family (Hsp40) member B11

increases expression

ISO

Benztropine results in increased expression of DNAJB11 protein

NCBI chr11:91,656,334...91,672,800
Ensembl chr11:91,656,335...91,672,800

G

dipeptidylpeptidase 3

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of DPP3 protein

NCBI chr 1:211,634,067...211,657,898
Ensembl chr 1:211,634,068...211,658,310

G

dihydropyrimidinase-like 2

decreases expression

ISO

Benztropine results in decreased expression of DPYSL2 protein

NCBI chr15:45,181,041...45,287,065
Ensembl chr15:45,181,041...45,287,065

G

dihydropyrimidinase-like 3

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of DPYSL3 protein

NCBI chr18:35,625,357...35,731,152
Ensembl chr18:35,625,357...35,731,152

G

dynein cytoplasmic 1 light intermediate chain 1

decreases expression

ISO

Benztropine results in decreased expression of DYNC1LI1 protein

NCBI chr 8:123,254,823...123,288,496
Ensembl chr 8:123,254,859...123,289,167

G

EBNA1 binding protein 2

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of EBNA1BP2 protein

NCBI chr 5:137,433,534...137,438,100
Ensembl chr 5:137,433,226...137,438,637

G

eukaryotic translation elongation factor 1 gamma

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of EEF1G protein

NCBI chr 1:215,289,815...215,300,421
Ensembl chr 1:215,277,860...215,301,479

G

eukaryotic translation initiation factor 2 subunit gamma

increases expression

ISO

Benztropine results in increased expression of EIF2S3 protein

NCBI chr X:62,910,292...62,933,936
Ensembl chr X:62,910,293...62,934,489

G

eukaryotic translation initiation factor 3, subunit B

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of EIF3B protein

NCBI chr12:19,310,308...19,334,768
Ensembl chr12:19,310,311...19,334,939

G

eukaryotic translation initiation factor 3, subunit C

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of EIF3C protein

NCBI chr 1:190,565,183...190,583,067
Ensembl chr 1:190,565,184...190,583,067

G

eukaryotic translation initiation factor 3, subunit H

decreases expression

ISO

Benztropine results in decreased expression of EIF3H protein

NCBI chr 7:84,980,891...85,064,284
Ensembl chr 7:84,980,891...85,071,546

G

eukaryotic translation initiation factor 3, subunit L

increases expression
multiple interactions

ISO

Benztropine results in increased expression of EIF3L protein
[Cuprizone co-treated with Benztropine] results in decreased expression of EIF3L protein

NCBI chr 7:112,522,222...112,544,063
Ensembl chr 7:112,507,831...112,544,062

G

eukaryotic translation initiation factor 5

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of EIF5 protein

NCBI chr 6:136,410,333...136,418,827
Ensembl chr 6:136,407,440...136,418,821

G

eukaryotic translation initiation factor 5B

multiple interactions
increases expression

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of EIF5B protein
Benztropine results in increased expression of EIF5B protein

NCBI chr 9:47,718,706...47,773,289
Ensembl chr 9:47,718,706...47,778,583

G

eukaryotic translation initiation factor 6

decreases expression

ISO

Benztropine results in decreased expression of EIF6 protein

NCBI chr 3:164,785,162...164,791,410
Ensembl chr 3:164,785,163...164,791,525

G

enolase 1

decreases expression

ISO

Benztropine results in decreased expression of ENO1 protein

NCBI chr 5:166,002,867...166,014,252
Ensembl chr 3:77,946,261...77,986,003
Ensembl chr 5:77,946,261...77,986,003

G

Eph receptor B3

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of EPHB3 protein

NCBI chr11:93,345,098...93,363,775
Ensembl chr11:93,345,098...93,363,775

G

Epsin 1

decreases expression

ISO

Benztropine results in decreased expression of EPN1 protein

NCBI chr 1:77,771,335...77,789,411
Ensembl chr 1:77,771,335...77,789,411

G

EGFR pathway substrate 8, signaling adaptor

decreases expression

ISO

Benztropine results in decreased expression of EPS8 protein

NCBI chr 4:172,119,497...172,291,670
Ensembl chr 4:172,119,497...172,218,160

G

ERH, mRNA splicing and mitosis factor

increases expression

ISO

Benztropine results in increased expression of ERH protein

NCBI chr 6:106,012,255...106,022,521
Ensembl chr 6:106,012,255...106,022,623

G

ER lipid raft associated 2

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of ERLIN2 protein

NCBI chr16:71,720,486...71,736,999
Ensembl chr16:71,721,364...71,736,503

G

EWS RNA-binding protein 1

decreases expression

ISO

Benztropine results in decreased expression of EWSR1 protein

NCBI chr14:84,179,413...84,208,149
Ensembl chr14:84,179,618...84,208,095

G

exosome component 9

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of EXOSC9 protein

NCBI chr 2:121,344,154...121,355,110
Ensembl chr 2:121,344,175...121,374,232

G

ezrin

decreases expression

ISO

Benztropine results in decreased expression of EZR protein

NCBI chr 1:49,373,033...49,416,573
Ensembl chr 1:49,373,035...49,416,573

G

fatty acid binding protein 3

increases expression

ISO

Benztropine results in increased expression of FABP3 protein

NCBI chr 5:147,936,027...147,942,870
Ensembl chr 5:147,936,119...147,942,881

G

farnesyl diphosphate synthase

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of FDPS protein

NCBI chr 2:176,795,192...176,804,816
Ensembl chr 2:176,795,192...176,807,136

G

flotillin 2

increases expression

ISO

Benztropine results in increased expression of FLOT2 protein

NCBI chr10:63,424,084...63,445,811
Ensembl chr10:63,423,806...63,445,810

G

Fms related receptor tyrosine kinase 1

decreases expression

ISO

Benztropine results in decreased expression of FLT1 protein

NCBI chr12:12,333,050...12,504,750
Ensembl chr12:12,333,430...12,504,750

G

FYVE and coiled-coil domain autophagy adaptor 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of FYCO1 protein

NCBI chr 8:132,289,538...132,356,810
Ensembl chr 8:132,289,539...132,356,451

G

G3BP stress granule assembly factor 2

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of G3BP2 protein

NCBI chr14:16,216,684...16,304,828
Ensembl chr14:16,248,744...16,304,823

G

glucose-6-phosphate dehydrogenase

decreases expression

ISO

Benztropine results in decreased expression of G6PD protein

NCBI chr X:157,352,364...157,372,144
Ensembl chr X:157,352,373...157,372,144

G

polypeptide N-acetylgalactosaminyltransferase 2

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of GALNT2 protein

NCBI chr19:69,110,657...69,222,237
Ensembl chr19:69,110,657...69,222,237

G

phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of GART protein

NCBI chr11:44,351,841...44,377,086
Ensembl chr11:44,351,851...44,377,086

G

GATA zinc finger domain containing 2B

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of GATAD2B protein

NCBI chr 2:178,046,192...178,127,633
Ensembl chr 2:178,046,085...178,147,315

G

guanine deaminase

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of GDA protein

NCBI chr 1:228,333,401...228,408,901
Ensembl chr 1:228,333,364...228,409,348

G

glutamine fructose-6-phosphate transaminase 1

decreases expression

ISO

Benztropine results in decreased expression of GFPT1 protein

NCBI chr 4:121,054,023...121,103,799
Ensembl chr 4:121,054,045...121,103,799

G

gamma-glutamyl cyclotransferase

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of GGCT protein

NCBI chr 4:85,453,387...85,459,597
Ensembl chr 4:85,453,387...85,470,224

G

glutaredoxin 3

increases expression

ISO

Benztropine results in increased expression of GLRX3 protein

NCBI chr 1:201,671,410...201,701,722
Ensembl chr 1:201,671,481...201,701,717

G

glutaminase

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of GLS protein

NCBI chr 9:56,836,584...56,908,861
Ensembl chr 9:56,836,584...56,908,861

G

G protein subunit alpha 12

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of GNA12 protein

NCBI chr12:18,919,629...19,000,185
Ensembl chr12:18,919,629...19,000,185

G

golgin A4

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of GOLGA4 protein

NCBI chr 8:127,085,830...127,163,227
Ensembl chr 8:127,085,848...127,163,603

G

golgin B1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of GOLGB1 protein

NCBI chr11:77,348,573...77,406,165
Ensembl chr11:77,348,961...77,406,006

G

glutamic-oxaloacetic transaminase 2

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of GOT2 protein

NCBI chr19:9,180,428...9,206,113
Ensembl chr19:9,180,431...9,206,111

G

glucose-6-phosphate isomerase

increases expression

ISO

Benztropine results in increased expression of GPI protein

NCBI chr 1:95,965,389...95,996,932
Ensembl chr 1:95,965,396...95,993,261

G

G patch domain and KOW motifs

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of GPKOW protein

NCBI chr X:17,463,521...17,478,298
Ensembl chr X:17,463,525...17,478,298

G

general transcription factor IIE subunit 1

decreases expression

ISO

Benztropine results in decreased expression of GTF2E1 protein

NCBI chr11:76,687,382...76,720,253
Ensembl chr11:76,687,772...76,720,784

G

general transcription factor IIF subunit 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of GTF2F1 protein

NCBI chr 9:1,931,033...1,940,197
Ensembl chr 9:1,930,055...1,940,197

G

GTP binding protein 4

increases expression

ISO

Benztropine results in increased expression of GTPBP4 protein

NCBI chr17:65,997,472...66,019,530
Ensembl chr17:66,276,566...66,289,637

G

glycogen synthase 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of GYS1 protein

NCBI chr 1:105,051,916...105,071,763
Ensembl chr 1:105,051,961...105,072,419

G

H2A clustered histone 20

increases expression

ISO

Benztropine results in increased expression of H2AC20 protein

NCBI chr 2:186,468,748...186,469,226

G

H2A.J histone

increases expression

ISO

Benztropine results in increased expression of H2AJ protein

NCBI chr 4:171,406,922...171,407,406
Ensembl chr 4:171,406,177...171,408,845

G

3-hydroxyacyl-CoA dehydratase 3

increases expression

ISO

Benztropine results in increased expression of HACD3 protein

NCBI chr 8:74,396,441...74,433,700
Ensembl chr 8:74,396,442...74,433,700

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta

increases expression

ISO

Benztropine results in increased expression of HADHB protein

NCBI chr 6:31,873,404...31,907,557
Ensembl chr 6:31,873,404...31,907,835

G

histidyl-tRNA synthetase 1

increases expression

ISO

Benztropine results in increased expression of HARS1 protein

NCBI chr18:28,655,669...28,672,712
Ensembl chr18:28,655,671...28,672,712

G

histone acetyltransferase 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of HAT1 protein

NCBI chr 3:76,624,442...76,672,701
Ensembl chr 3:76,624,869...76,672,696

G

host cell factor C1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of HCFC1 protein

NCBI chr X:156,839,100...156,864,132
Ensembl chr X:156,839,100...156,863,813

G

hemicentin 2

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of HMCN2 protein

NCBI chr 3:34,986,246...35,136,047
Ensembl chr 3:34,986,263...35,136,106

G

heterogeneous nuclear ribonucleoprotein D

decreases expression

ISO

Benztropine results in decreased expression of HNRNPD protein

NCBI chr14:9,918,630...9,938,072
Ensembl chr14:9,919,739...9,938,066

G

heterogeneous nuclear ribonucleoprotein K

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of HNRNPK protein

NCBI chr17:6,269,302...6,280,429
Ensembl chr17:6,268,385...6,280,565

G

HPS3, biogenesis of lysosomal organelles complex 2 subunit 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of HPS3 protein

NCBI chr 2:104,413,618...104,455,091
Ensembl chr 2:104,413,417...104,455,091

G

hydroxysteroid (17-beta) dehydrogenase 12

increases expression

ISO

Benztropine results in increased expression of HSD17B12 protein

NCBI chr 3:100,445,393...100,568,898
Ensembl chr 3:100,445,400...100,568,938

G

hydroxysteroid (17-beta) dehydrogenase 4

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of HSD17B4 protein

NCBI chr18:45,515,427...45,604,467
Ensembl chr18:45,515,373...45,604,467

G

heat shock protein 90 beta family member 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of HSP90B1 protein

NCBI chr 7:22,997,962...23,012,293
Ensembl chr 7:22,997,962...23,012,293

G

isopentenyl-diphosphate delta isomerase 1

decreases expression

ISO

Benztropine results in decreased expression of IDI1 protein

NCBI chr17:66,539,761...66,547,524
Ensembl chr17:66,539,763...66,547,524

G

interleukin 1 alpha

decreases expression

ISO

Benztropine results in decreased expression of IL1A mRNA

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013

G

interleukin 1 beta

decreases expression

ISO

Benztropine results in decreased expression of IL1B mRNA

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 24

increases expression

ISO

Benztropine results in increased expression of IL24 mRNA

NCBI chr13:44,905,362...44,910,760
Ensembl chr13:44,905,363...44,910,760

G

junctional adhesion molecule 3

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of JAM3 protein

NCBI chr 8:33,767,606...33,828,451
Ensembl chr 8:33,767,607...33,828,623

G

Jupiter microtubule associated homolog 2

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of JPT2 protein

NCBI chr10:14,467,652...14,487,769
Ensembl chr10:14,467,661...14,535,664

G

lysyl-tRNA synthetase 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of KARS1 protein

NCBI chr19:56,867,096...56,886,151
Ensembl chr19:56,867,096...56,886,073

G

potassium voltage-gated channel subfamily H member 2

decreases activity

ISO

Benztropine results in decreased activity of KCNH2 protein

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

G

potassium channel tetramerization domain containing 12

decreases expression

ISO

Benztropine results in decreased expression of KCTD12 protein

NCBI chr15:86,214,786...86,220,725
Ensembl chr15:86,214,840...86,224,539

G

KH RNA binding domain containing, signal transduction associated 1

decreases expression

ISO

Benztropine results in decreased expression of KHDRBS1 protein

NCBI chr 5:147,337,048...147,374,604
Ensembl chr 5:147,347,904...147,373,448

G

kinesin family member 5C

decreases expression

ISO

Benztropine results in decreased expression of KIF5C protein

NCBI chr 3:54,441,266...54,591,630
Ensembl chr 3:54,441,310...54,594,813

G

kelch domain containing 2

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of KLHDC2 protein

NCBI chr 6:93,512,981...93,552,809
Ensembl chr 6:93,513,017...93,577,762

G

kelch-like family member 41

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of KLHL41 protein

NCBI chr 3:74,842,118...74,855,244

G

karyopherin subunit alpha 4

increases expression

ISO

Benztropine results in increased expression of KPNA4 protein

NCBI chr 2:155,635,679...155,691,056
Ensembl chr 2:155,634,247...155,691,053

G

kinectin 1

multiple interactions
decreases expression

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of KTN1 protein
Benztropine results in decreased expression of KTN1 protein

NCBI chr15:23,392,570...23,485,061
Ensembl chr15:23,394,315...23,482,263

G

lactamase, beta 2

increases expression

ISO

Benztropine results in increased expression of LACTB2 protein

NCBI chr 5:10,352,165...10,374,928
Ensembl chr 5:10,352,154...10,379,255

G

laminin subunit beta 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of LAMB1 protein

NCBI chr 6:53,562,849...53,630,118
Ensembl chr 6:53,563,073...53,630,760

G

laminin subunit gamma 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of LAMC1 protein

NCBI chr13:67,924,872...68,051,986
Ensembl chr13:67,924,872...68,051,986

G

LIM domain and actin binding 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of LIMA1 protein

NCBI chr 7:132,780,556...132,880,343
Ensembl chr 7:132,780,556...132,880,386

G

lipase A, lysosomal acid type

increases expression

ISO

Benztropine results in increased expression of LIPA protein

NCBI chr 1:241,437,524...241,470,936
Ensembl chr 1:241,437,524...241,470,740

G

leiomodin 2

increases expression

ISO

Benztropine results in increased expression of LMOD2 protein

NCBI chr 4:54,032,974...54,040,670
Ensembl chr 4:54,032,974...54,040,666

G

lanosterol synthase

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of LSS protein

NCBI chr20:12,090,641...12,118,230
Ensembl chr20:12,073,543...12,118,253

G

leukotriene A4 hydrolase

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of LTA4H protein

NCBI chr 7:29,856,846...29,888,642
Ensembl chr 7:29,856,802...29,888,641

G

LUC7 pre-mRNA splicing factor like 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of LUC7L protein

NCBI chr10:15,777,837...15,811,586
Ensembl chr10:15,777,829...15,817,940

G

MAGE family member A9

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of MAGEA9 protein

NCBI chr X:147,655,721...147,661,093
Ensembl chr X:147,655,721...147,661,093

G

MAGE family member D2

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of MAGED2 protein

NCBI chr X:23,160,928...23,364,994
Ensembl chr X:23,160,931...23,169,104

G

microtubule-associated protein 1S

increases expression

ISO

Benztropine results in increased expression of MAP1S protein

NCBI chr16:18,551,573...18,561,760
Ensembl chr16:18,551,573...18,562,141

G

microtubule-associated protein 4

decreases expression

ISO

Benztropine results in decreased expression of MAP4 protein

NCBI chr 8:118,800,393...118,942,805
Ensembl chr 8:118,804,022...118,942,805

G

microtubule-associated protein, RP/EB family, member 1

decreases expression

ISO

Benztropine results in decreased expression of MAPRE1 protein

NCBI chr 3:162,679,020...162,707,167
Ensembl chr 3:162,673,195...162,711,210

G

MARCKS-like 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of MARCKSL1 protein

NCBI chr 5:147,135,827...147,138,150
Ensembl chr 5:147,134,514...147,138,417

G

methionine adenosyltransferase 2 non-catalytic beta subunit

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of MAT2B protein

NCBI chr10:25,609,202...25,626,694
Ensembl chr10:25,609,204...25,625,176

G

membrane bound O-acyltransferase domain containing 7

decreases expression

ISO

Benztropine results in decreased expression of MBOAT7 protein

NCBI chr 1:74,440,618...74,454,896
Ensembl chr 1:74,439,660...74,454,894

G

malate dehydrogenase 1

decreases expression

ISO

Benztropine results in decreased expression of MDH1 protein

NCBI chr14:99,831,934...99,847,227
Ensembl chr14:99,831,615...99,847,232

G

MET proto-oncogene, receptor tyrosine kinase

increases expression

ISO

Benztropine results in increased expression of MET mRNA

NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:46,756,506...46,870,821

G

methionyl aminopeptidase 2

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of METAP2 protein

NCBI chr 7:30,299,433...30,327,477
Ensembl chr 7:30,299,433...30,327,521

G

macrophage migration inhibitory factor

increases expression

ISO

Benztropine results in increased expression of MIF protein

NCBI chr20:12,767,138...12,791,222
Ensembl chr 4:134,041,774...134,042,121
Ensembl chr20:134,041,774...134,042,121

G

metadherin

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of MTDH protein

NCBI chr 7:67,192,592...67,250,819
Ensembl chr 7:67,192,393...67,249,584

G

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of MTHFD1L protein

NCBI chr 1:42,849,424...43,038,313
Ensembl chr 1:42,849,374...43,038,309

G

myosin heavy chain 3

increases expression

ISO

Benztropine results in increased expression of MYH3 protein

NCBI chr10:52,269,185...52,293,000
Ensembl chr10:52,269,185...52,293,000

G

N-acetyltransferase 10

decreases expression

ISO

Benztropine results in decreased expression of NAT10 protein

NCBI chr 3:110,566,582...110,604,829
Ensembl chr 3:110,566,582...110,604,836

G

nuclear cap binding protein subunit 1

decreases expression

ISO

Benztropine results in decreased expression of NCBP1 protein

NCBI chr 5:65,211,632...65,244,532
Ensembl chr 5:65,211,358...65,244,665

G

nectin cell adhesion molecule 2

decreases expression

ISO

Benztropine results in decreased expression of NECTIN2 protein

NCBI chr 1:88,500,086...88,535,474
Ensembl chr 1:88,500,087...88,535,305

G

nicotinamide N-methyltransferase

increases expression

ISO

Benztropine results in increased expression of NNMT protein

NCBI chr 8:57,820,156...57,851,301
Ensembl chr 8:57,825,464...57,843,174

G

NOC2-like nucleolar associated transcriptional repressor

increases expression

ISO

Benztropine results in increased expression of NOC2L protein

NCBI chr 5:172,102,369...172,114,168
Ensembl chr 5:172,101,223...172,114,162

G

N-ethylmaleimide sensitive factor, vesicle fusing ATPase

decreases expression

ISO

Benztropine results in decreased expression of NSF protein

NCBI chr10:89,227,937...89,357,383
Ensembl chr10:89,227,937...89,367,621

G

NSFL1 cofactor

decreases expression

ISO

Benztropine results in decreased expression of NSFL1C protein

NCBI chr 3:160,438,708...160,463,261
Ensembl chr 3:160,438,708...160,463,228

G

nuclear mitotic apparatus protein 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of NUMA1 protein

NCBI chr 1:165,709,893...165,784,848
Ensembl chr 1:165,709,905...165,784,848

G

nucleoporin 153

increases expression

ISO

Benztropine results in increased expression of NUP153 protein

NCBI chr17:18,178,434...18,231,109
Ensembl chr17:18,178,456...18,231,109

G

nucleoporin 50

increases expression

ISO

Benztropine results in increased expression of NUP50 protein

NCBI chr 7:117,927,882...117,945,155
Ensembl chr 7:117,925,716...117,946,959

G

nucleoporin 54

decreases expression

ISO

Benztropine results in decreased expression of NUP54 protein

NCBI chr14:15,901,936...15,920,335
Ensembl chr14:15,901,991...15,920,334

G

nucleoporin 93

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of NUP93 protein

NCBI chr19:10,690,154...10,793,937
Ensembl chr19:10,687,115...10,793,380

G

nuclear RNA export factor 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of NXF1 protein

NCBI chr 1:215,084,563...215,097,756
Ensembl chr 1:215,084,099...215,097,756

G

ornithine aminotransferase

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of OAT protein

NCBI chr 1:196,777,973...196,797,754
Ensembl chr 1:196,777,975...196,797,754

G

oxoglutarate dehydrogenase

decreases expression

ISO

Benztropine results in decreased expression of OGDH protein

NCBI chr14:85,363,949...85,431,405
Ensembl chr14:85,364,014...85,432,271

G

Obg-like ATPase 1

increases expression

ISO

Benztropine results in increased expression of OLA1 protein

NCBI chr 3:78,374,440...78,493,401
Ensembl chr 3:78,374,441...78,492,012

G

prolyl 4-hydroxylase subunit beta

decreases expression

ISO

Benztropine results in decreased expression of P4HB protein

NCBI chr10:106,335,300...106,346,911
Ensembl chr10:106,335,300...106,346,911

G

proliferation-associated 2G4

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of PA2G4 protein

NCBI chr 7:1,569,326...1,576,794
Ensembl chr 7:1,569,327...1,576,802

G

platelet-activating factor acetylhydrolase 1b, regulatory subunit 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of PAFAH1B1 protein

NCBI chr10:60,031,441...60,090,259
Ensembl chr10:60,032,514...60,090,196

G

phosphoprotein membrane anchor with glycosphingolipid microdomains 1

decreases expression

ISO

Benztropine results in decreased expression of PAG1 protein

NCBI chr 2:93,842,747...93,984,314
Ensembl chr 2:93,964,594...93,977,227

G

poly (ADP-ribose) polymerase 1

multiple interactions
decreases expression

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of PARP1 protein
Benztropine results in decreased expression of PARP1 protein

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

pyruvate carboxylase

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of PC protein

NCBI chr 1:211,228,708...211,327,792
Ensembl chr 1:211,228,731...211,329,940

G

poly(rC) binding protein 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of PCBP1 protein

NCBI chr 4:120,530,100...120,532,107
Ensembl chr 4:120,529,172...120,539,111

G

poly(rC) binding protein 2

decreases expression

ISO

Benztropine results in decreased expression of PCBP2 protein

NCBI chr 7:135,483,702...135,508,254
Ensembl chr 7:135,483,856...135,509,412

G

protocadherin gamma subfamily A, 2

decreases expression

ISO

Benztropine results in decreased expression of PCDHGA2 protein

NCBI chr18:29,745,189...29,919,095

G

protein-L-isoaspartate (D-aspartate) O-methyltransferase 1

decreases expression

ISO

Benztropine results in decreased expression of PCMT1 protein

NCBI chr 1:3,932,161...3,980,751
Ensembl chr 1:3,932,161...3,964,848

G

PEST proteolytic signal containing nuclear protein

increases expression

ISO

Benztropine results in increased expression of PCNP protein

NCBI chr11:58,061,885...58,076,436
Ensembl chr11:58,061,570...58,076,436

G

phosducin-like 3

decreases expression

ISO

Benztropine results in decreased expression of PDCL3 protein

NCBI chr 9:48,730,083...48,738,554
Ensembl chr 9:48,723,767...48,739,529

G

protein disulfide isomerase family A, member 3

decreases expression

ISO

Benztropine results in decreased expression of PDIA3 protein

NCBI chr 3:128,841,781...128,865,733
Ensembl chr 3:128,841,917...128,867,327

G

protein disulfide isomerase family A, member 6

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of PDIA6 protein

NCBI chr 6:45,791,704...45,808,947
Ensembl chr 6:45,791,678...45,810,091

G

PDZ and LIM domain 5

decreases expression

ISO

Benztropine results in decreased expression of PDLIM5 protein

NCBI chr 2:233,625,478...233,793,582
Ensembl chr 2:233,628,503...233,793,528

G

phosphatidylethanolamine binding protein 1

decreases expression

ISO

Benztropine results in decreased expression of PEBP1 protein

NCBI chr12:44,946,307...44,967,890
Ensembl chr12:44,963,675...44,971,780

G

profilin 1

increases expression

ISO

Benztropine results in increased expression of PFN1 protein

NCBI chr10:55,863,882...55,866,587
Ensembl chr10:55,863,881...55,868,611

G

phosphoglycerate kinase 1

decreases expression

ISO

Benztropine results in decreased expression of PGK1 protein

NCBI chr X:75,336,988...75,352,962
Ensembl chr X:75,336,687...75,352,959

G

phosphoglucomutase 3

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of PGM3 protein

NCBI chr 8:96,398,331...96,416,045
Ensembl chr 8:96,398,269...96,416,021

G

PHD finger protein 14

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of PHF14 protein

NCBI chr 4:40,975,897...41,162,043
Ensembl chr 4:40,975,439...41,162,043

G

phosphoglycerate dehydrogenase

decreases expression

ISO

Benztropine results in decreased expression of PHGDH protein

NCBI chr 2:188,595,700...188,624,789
Ensembl chr 2:188,595,700...188,624,789

G

phosphotyrosine interaction domain containing 1

increases expression

ISO

Benztropine results in increased expression of PID1 mRNA

NCBI chr 9:92,732,471...92,951,168
Ensembl chr 9:92,734,214...92,750,070

G

peptidylprolyl cis/trans isomerase, NIMA-interacting 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of PIN1 protein

NCBI chr 8:27,465,538...27,477,016

G

peptidase, mitochondrial processing subunit alpha

increases expression

ISO

Benztropine results in increased expression of PMPCA protein

NCBI chr 3:29,605,823...29,614,936
Ensembl chr 3:29,604,232...29,614,935

G

PNMA family member 1

increases expression

ISO

Benztropine results in increased expression of PNMA1 protein

NCBI chr 6:109,513,382...109,515,167
Ensembl chr 6:109,507,773...109,515,451

G

PNMA family member 8A

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of PNMA8A protein

NCBI chr 1:86,763,475...86,771,117
Ensembl chr 1:86,756,168...86,815,182

G

paraoxonase 3

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of PON3 protein

NCBI chr 4:34,323,546...34,350,244
Ensembl chr 4:34,315,889...34,350,244

G

inorganic pyrophosphatase 1

multiple interactions
increases expression

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of PPA1 protein
Benztropine results in increased expression of PPA1 protein

NCBI chr20:30,132,088...30,160,492
Ensembl chr20:30,133,504...30,160,489

G

protein phosphatase, Mg2+/Mn2+ dependent, 1F

decreases expression

ISO

Benztropine results in decreased expression of PPM1F protein

NCBI chr11:97,568,627...97,598,613
Ensembl chr11:97,568,625...97,598,545

G

protein phosphatase 1, regulatory subunit 12A

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of PPP1R12A protein

NCBI chr 7:45,368,922...45,480,158
Ensembl chr 7:45,369,315...45,480,157

G

protein phosphatase 1, regulatory (inhibitor) subunit 14B

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of PPP1R14B protein

NCBI chr 1:213,594,416...213,596,527
Ensembl chr12:21,088,517...21,101,431
Ensembl chr 1:21,088,517...21,101,431

G

protein phosphatase 3 catalytic subunit alpha

increases expression

ISO

Benztropine results in increased expression of PPP3CA protein

NCBI chr 2:227,839,058...228,113,560
Ensembl chr 2:227,839,062...228,113,554

G

protein kinase cAMP-dependent type II regulatory subunit alpha

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of PRKAR2A protein

NCBI chr 8:118,271,608...118,337,332
Ensembl chr 8:118,274,167...118,337,330

G

PRKCSH beta subunit of glucosidase II

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of PRKCSH protein

NCBI chr 8:28,810,836...28,822,503
Ensembl chr 8:28,810,889...28,822,503

G

protein arginine methyltransferase 1

decreases expression

ISO

Benztropine results in decreased expression of PRMT1 protein

NCBI chr 1:104,595,339...104,605,552
Ensembl chr 1:104,595,335...104,604,827

G

pre-mRNA processing factor 6

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of PRPF6 protein

NCBI chr 3:189,084,465...189,148,705
Ensembl chr 3:189,081,794...189,152,786

G

proteasome 20S subunit alpha 1

decreases expression

ISO

Benztropine results in decreased expression of PSMA1 protein

NCBI chr 1:177,876,838...177,887,857
Ensembl chr 1:177,875,353...177,887,949

G

proteasome 20S subunit beta 7

decreases expression

ISO

Benztropine results in decreased expression of PSMB7 protein

NCBI chr 3:42,767,500...42,827,470
Ensembl chr 3:42,767,501...42,827,601

G

proteasome 26S subunit, ATPase 1

decreases expression

ISO

Benztropine results in decreased expression of PSMC1 protein

NCBI chr 6:125,122,497...125,134,859
Ensembl chr 6:125,122,490...125,134,858

G

proteasome 26S subunit, ATPase 3

increases expression

ISO

Benztropine results in increased expression of PSMC3 protein

NCBI chr 3:97,487,643...97,493,025
Ensembl chr 3:97,487,632...97,499,176

G

proteasome 26S subunit, non-ATPase 7

increases expression

ISO

Benztropine results in increased expression of PSMD7 protein

NCBI chr19:52,404,032...52,411,316
Ensembl chr19:52,404,032...52,417,871

G

Pentatricopeptide repeat domain 3

increases expression
multiple interactions

ISO

Benztropine results in increased expression of PTCD3 protein
[Cuprizone co-treated with Benztropine] results in decreased expression of PTCD3 protein

NCBI chr 4:105,480,699...105,508,007
Ensembl chr 4:105,480,709...105,513,276

G

prostaglandin-endoperoxide synthase 2

decreases expression

ISO

Benztropine results in decreased expression of PTGS2 mRNA

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

protein tyrosine kinase 7

decreases expression

ISO

Benztropine results in decreased expression of PTK7 protein

NCBI chr 9:21,849,756...21,916,077
Ensembl chr 9:21,849,801...21,916,078

G

poly-U binding splicing factor 60

decreases expression

ISO

Benztropine results in decreased expression of PUF60 protein

NCBI chr 7:109,663,490...109,674,443
Ensembl chr 7:109,663,490...109,674,724

G

PWP2, small subunit processome component

increases expression

ISO

Benztropine results in increased expression of PWP2 protein

NCBI chr20:10,498,998...10,512,631
Ensembl chr20:10,499,013...10,513,309

G

pyrroline-5-carboxylate reductase 1

increases expression

ISO

Benztropine results in increased expression of PYCR1 protein

NCBI chr10:106,416,056...106,420,982
Ensembl chr10:106,412,576...106,423,393

G

quinoid dihydropteridine reductase

decreases expression

ISO

Benztropine results in decreased expression of QDPR protein

NCBI chr14:69,882,776...69,896,378
Ensembl chr14:69,882,612...69,896,379

G

receptor for activated C kinase 1

decreases expression

ISO

Benztropine results in decreased expression of RACK1 protein

NCBI chr10:33,668,560...33,676,031
Ensembl chr10:33,670,270...33,675,948

G

RNA binding motif protein 15

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of RBM15 protein

NCBI chr 2:197,634,174...197,642,697
Ensembl chr 2:197,583,002...197,643,037

G

RIC8 guanine nucleotide exchange factor A

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of RIC8A protein

NCBI chr 1:205,364,796...205,371,102
Ensembl chr 1:205,363,882...205,371,102

G

ribosomal protein L10A

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of RPL10A protein

NCBI chr20:6,390,533...6,393,091
Ensembl chr20:6,390,179...6,393,091

G

ribosomal protein L19

increases expression

ISO

Benztropine results in increased expression of RPL19 protein

NCBI chr10:83,514,509...83,522,352
Ensembl chr10:83,515,464...83,522,352

G

ribosomal protein L24

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of RPL24 protein

NCBI chr11:58,122,997...58,128,405
Ensembl chr11:58,122,997...58,128,405

G

ribosomal protein L30

increases expression

ISO

Benztropine results in increased expression of RPL30 protein

NCBI chr 7:67,533,420...67,536,555
Ensembl chr 7:67,465,332...67,536,555

G

ribosomal protein L7A

decreases expression

ISO

Benztropine results in decreased expression of RPL7A protein

NCBI chr 3:30,637,136...30,639,778
Ensembl chr 3:30,637,059...30,639,791
Ensembl chr18:30,637,059...30,639,791

G

ribosomal protein lateral stalk subunit P1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of RPLP1 protein

NCBI chr 8:71,289,539...71,290,872
Ensembl chr 8:71,289,535...71,290,872

G

ribosomal protein S12

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of RPS12 protein

NCBI chr 1:23,499,943...23,502,234
Ensembl chr 1:23,500,073...23,502,235

G

ribosomal protein S18

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of RPS18 protein

NCBI chr20:4,933,741...4,937,423
Ensembl chr20:4,917,095...4,937,423

G

ribosomal protein S27

increases expression

ISO

Benztropine results in increased expression of RPS27 protein

NCBI chr 2:177,963,499...177,964,708
Ensembl chr 2:177,963,496...177,964,607
Ensembl chr12:177,963,496...177,964,607

G

ribosomal protein S27a

increases expression

ISO

Benztropine results in increased expression of RPS27A protein

NCBI chr14:107,486,664...107,488,941
Ensembl chr 5:138,465,088...138,466,080
Ensembl chr14:138,465,088...138,466,080
Ensembl chr 5:138,465,088...138,466,080

G

ribosomal protein S3

decreases expression

ISO

Benztropine results in decreased expression of RPS3 protein

NCBI chr 1:163,190,476...163,195,885
Ensembl chr 1:163,189,842...163,195,776

G

RuvB-like AAA ATPase 2

increases expression

ISO

Benztropine results in increased expression of RUVBL2 protein

NCBI chr 1:105,038,487...105,051,851
Ensembl chr 1:105,038,174...105,051,720

G

SUMO1 activating enzyme subunit 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of SAE1 protein

NCBI chr 1:86,159,114...86,215,089
Ensembl chr 1:86,159,114...86,215,089

G

seryl-tRNA synthetase 1

decreases expression

ISO

Benztropine results in decreased expression of SARS1 protein

NCBI chr 2:198,753,673...198,769,411
Ensembl chr 2:198,753,675...198,769,365

G

SATB homeobox 2

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of SATB2 protein

NCBI chr 9:65,842,351...66,028,569
Ensembl chr 9:65,844,570...66,021,238

G

saccharopine dehydrogenase (putative)

decreases expression

ISO

Benztropine results in decreased expression of SCCPDH protein

NCBI chr13:93,932,086...93,953,840
Ensembl chr13:93,912,395...93,954,192

G

syndecan binding protein

decreases expression

ISO

Benztropine results in decreased expression of SDCBP protein

NCBI chr 5:24,245,279...24,314,712
Ensembl chr 5:24,245,033...24,326,197

G

Sec23 homolog A, COPII coat complex component

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of SEC23A protein

NCBI chr 6:82,393,699...82,442,594
Ensembl chr 6:82,394,863...82,440,904

G

SEC61 translocon subunit beta

increases expression

ISO

Benztropine results in increased expression of SEC61B protein

NCBI chr 5:66,569,184...66,577,394
Ensembl chr 5:66,569,196...66,580,028

G

SEC63 homolog, protein translocation regulator

increases expression

ISO

Benztropine results in increased expression of SEC63 protein

NCBI chr20:47,827,291...47,896,248
Ensembl chr20:47,827,291...47,896,248

G

Serpine1 mRNA binding protein 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of SERBP1 protein

NCBI chr 4:97,731,200...97,748,438
Ensembl chr 4:97,731,277...97,751,518

G

serpin family B member 3A

increases expression

ISO

Benztropine results in increased expression of SERPINB4 protein

NCBI chr13:23,755,690...23,766,188
Ensembl chr13:23,756,118...23,766,341

G

splicing factor 1

decreases expression

ISO

Benztropine results in decreased expression of SF1 protein

NCBI chr 1:213,090,256...213,112,688
Ensembl chr 1:213,099,260...213,113,590

G

splicing factor 3b, subunit 3

decreases expression

ISO

Benztropine results in decreased expression of SF3B3 protein

NCBI chr19:55,692,124...55,729,640
Ensembl chr19:55,692,126...55,729,621

G

sarcoglycan, alpha

decreases expression

ISO

Benztropine results in decreased expression of SGCA protein

NCBI chr10:80,397,158...80,416,165
Ensembl chr10:80,405,566...80,419,616

G

SH3 and PX domains 2B

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of SH3PXD2B protein

NCBI chr10:17,422,906...17,538,977
Ensembl chr10:17,422,947...17,512,854

G

serine hydroxymethyltransferase 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of SHMT1 protein

NCBI chr10:45,968,959...45,990,341
Ensembl chr10:45,960,434...45,997,326

G

solute carrier family 22 member 2

multiple interactions

ISO

Benztropine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

G

solute carrier family 25 member 5, pseudogene 11

increases expression

ISO

Benztropine results in increased expression of SLC25A6 protein

NCBI chr18:70,846,358...70,847,597
Ensembl chr18:70,846,358...70,847,597

G

solute carrier family 2 member 1

decreases expression

ISO

Benztropine results in decreased expression of SLC2A1 protein

NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:138,002,522...138,030,742

G

solute carrier family 38, member 2

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of SLC38A2 protein

NCBI chr 7:129,730,450...129,742,619
Ensembl chr 7:129,730,450...129,742,619

G

solute carrier family 3 member 2

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of SLC3A2 protein

NCBI chr 1:215,033,601...215,048,064
Ensembl chr 1:215,033,601...215,048,064

G

solute carrier family 6 member 3

multiple interactions

ISO

Benztropine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]

NCBI chr 1:31,537,990...31,578,962
Ensembl chr 1:31,537,990...31,578,962

G

secretory leukocyte peptidase inhibitor

increases expression

ISO

Benztropine results in increased expression of SLPI mRNA

NCBI chr 3:173,501,573...173,503,822
Ensembl chr 3:173,501,573...173,503,822

G

SWI/SNF related BAF chromatin remodeling complex subunit B1

decreases expression

ISO

Benztropine results in decreased expression of SMARCB1 protein

NCBI chr20:12,740,105...12,763,054
Ensembl chr20:12,740,943...12,763,055

G

structural maintenance of chromosomes 3

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of SMC3 protein

NCBI chr 1:262,606,731...262,649,832
Ensembl chr 1:262,607,080...262,649,825

G

SMU1, DNA replication regulator and spliceosomal factor

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of SMU1 protein

NCBI chr 5:60,652,680...60,671,251
Ensembl chr 5:60,652,680...60,671,251

G

small nuclear ribonucleoprotein U5 subunit 200

multiple interactions
increases expression

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of SNRNP200 protein
Benztropine results in increased expression of SNRNP200 protein

NCBI chr 3:134,882,173...134,911,512
Ensembl chr 3:134,882,173...134,911,500

G

small nuclear ribonucleoprotein polypeptide A

increases expression

ISO

Benztropine results in increased expression of SNRPA protein

NCBI chr 1:91,609,419...91,618,119
Ensembl chr 1:91,609,420...91,618,042

G

small nuclear ribonucleoprotein D2 polypeptide

increases expression

ISO

Benztropine results in increased expression of SNRPD2 protein

NCBI chr 1:87,926,030...87,929,259
Ensembl chr 1:87,926,048...87,933,339
Ensembl chr20:87,926,048...87,933,339

G

splicing regulatory glutamic acid and lysine rich protein 1

decreases expression

ISO

Benztropine results in decreased expression of SREK1 protein

NCBI chr 2:36,583,412...36,618,978
Ensembl chr 2:36,583,412...36,619,001

G

serine and arginine rich splicing factor 5

increases expression

ISO

Benztropine results in increased expression of SRSF5 protein

NCBI chr 6:106,333,998...106,341,467
Ensembl chr 6:106,336,756...106,341,931

G

signal transducer and activator of transcription 3

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of STAT3 protein

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

G

stromal interaction molecule 1

decreases expression

ISO

Benztropine results in decreased expression of STIM1 protein

NCBI chr 1:166,067,450...166,230,733
Ensembl chr 1:166,067,962...166,233,108

G

stress-induced phosphoprotein 1

decreases expression

ISO

Benztropine results in decreased expression of STIP1 protein

NCBI chr 1:213,638,641...213,657,654
Ensembl chr 1:213,638,641...213,657,654

G

serine/threonine kinase receptor associated protein

decreases expression

ISO

Benztropine results in decreased expression of STRAP protein

NCBI chr 4:172,377,325...172,391,573
Ensembl chr 4:172,377,305...172,392,436

G

STIP1 homology and U-box containing protein 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of STUB1 protein

NCBI chr10:15,355,278...15,357,559
Ensembl chr10:15,355,279...15,357,559

G

succinate-CoA ligase GDP/ADP-forming subunit alpha

decreases expression

ISO

Benztropine results in decreased expression of SUCLG1 protein

NCBI chr 4:106,866,329...106,895,686
Ensembl chr 4:106,866,114...106,895,689

G

small ubiquitin-like modifier 2

decreases expression

ISO

Benztropine results in decreased expression of SUMO2 protein

NCBI chr10:101,270,899...101,283,458
Ensembl chr10:101,270,900...101,283,938
Ensembl chr 5:101,270,900...101,283,938

G

Sad1 and UNC84 domain containing 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of SUN1 protein

NCBI chr12:20,510,230...20,555,123
Ensembl chr12:20,490,861...20,555,240

G

synaptotagmin binding, cytoplasmic RNA interacting protein

decreases expression

ISO

Benztropine results in decreased expression of SYNCRIP protein

NCBI chr 8:98,282,358...98,315,412
Ensembl chr 8:98,282,358...98,315,386

G

transgelin 2

decreases expression

ISO

Benztropine results in decreased expression of TAGLN2 protein

NCBI chr13:87,499,350...87,506,328
Ensembl chr13:87,499,394...87,506,330

G

tubulin folding cofactor B

decreases expression

ISO

Benztropine results in decreased expression of TBCB protein

NCBI chr 1:94,605,100...94,610,949
Ensembl chr 1:94,605,101...94,610,949

G

TRPM8 channel-associated factor 1

multiple interactions
decreases expression

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of TCAF1 protein
Benztropine results in decreased expression of TCAF1 protein

NCBI chr 4:72,589,710...72,639,304
Ensembl chr 4:72,589,710...72,639,475

G

trans-golgi network protein 2

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of TGOLN2 protein

NCBI chr 4:106,221,503...106,229,360
Ensembl chr 4:106,221,509...106,229,262

G

talin 2

decreases expression

ISO

Benztropine results in decreased expression of TLN2 protein

NCBI chr 8:76,712,112...77,133,361
Ensembl chr 8:76,712,112...77,133,361

G

thymopoietin

decreases expression

ISO

Benztropine results in decreased expression of TMPO protein

NCBI chr 7:27,529,977...27,554,980
Ensembl chr 7:27,529,978...27,554,937

G

tankyrase 1 binding protein 1

multiple interactions
decreases expression

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of TNKS1BP1 protein
Benztropine results in decreased expression of TNKS1BP1 protein

NCBI chr 3:90,542,006...90,566,720
Ensembl chr 3:90,542,033...90,566,713

G

translocase of outer mitochondrial membrane 34

decreases expression
multiple interactions

ISO

Benztropine results in decreased expression of TOMM34 protein
[Cuprizone co-treated with Benztropine] results in increased expression of TOMM34 protein

NCBI chr 3:173,148,737...173,165,689
Ensembl chr 3:173,145,279...173,165,814

G

DNA topoisomerase I mitochondrial

increases expression

ISO

Benztropine results in increased expression of TOP1MT protein

NCBI chr 7:109,223,269...109,248,855
Ensembl chr 7:109,139,527...109,246,799

G

tropomyosin 2

decreases expression

ISO

Benztropine results in decreased expression of TPM2 protein

NCBI chr 5:62,566,712...62,576,066
Ensembl chr 5:62,566,652...62,575,726

G

tropomyosin 3

decreases expression

ISO

Benztropine results in decreased expression of TPM3 protein

NCBI chr 2:177,812,534...177,842,661
Ensembl chr 2:177,814,883...177,842,660

G

translocated promoter region, nuclear basket protein

decreases expression

ISO

Benztropine results in decreased expression of TPR protein

NCBI chr13:64,974,419...65,037,604
Ensembl chr13:64,974,419...65,037,602

G

tripartite motif-containing 28

decreases expression
multiple interactions

ISO

Benztropine results in decreased expression of TRIM28 protein
[Cuprizone co-treated with Benztropine] results in increased expression of TRIM28 protein

NCBI chr 1:82,724,842...82,731,566
Ensembl chr 1:82,724,838...82,731,572

G

tetraspanin 3

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of TSPAN3 protein

NCBI chr 8:65,442,100...65,465,961
Ensembl chr 8:65,442,101...65,465,844

G

tetratricopeptide repeat domain 21A

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of TTC21A protein

NCBI chr 8:128,544,684...128,580,464
Ensembl chr 8:128,544,734...128,580,086

G

tweety family member 2

increases expression

ISO

Benztropine results in increased expression of TTYH2 protein

NCBI chr10:100,208,129...100,252,505
Ensembl chr10:100,207,860...100,253,521

G

tweety family member 3

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of TTYH3 protein

NCBI chr12:19,110,973...19,139,379
Ensembl chr12:19,110,824...19,139,371

G

tubulin, beta 5 class I

increases expression

ISO

Benztropine results in increased expression of TUBB protein

NCBI chr20:2,917,577...2,921,726
Ensembl chr20:2,917,539...2,921,726

G

twinfilin actin-binding protein 2

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of TWF2 protein

NCBI chr 8:115,723,980...115,737,025
Ensembl chr 8:115,723,970...115,737,025

G

taxilin alpha

decreases expression

ISO

Benztropine results in decreased expression of TXLNA protein

NCBI chr 5:147,253,694...147,269,410
Ensembl chr 5:147,255,649...147,269,273

G

thymidylate synthetase

increases expression

ISO

Benztropine results in increased expression of TYMS protein

NCBI chr 9:120,760,057...120,776,149
Ensembl chr 9:120,763,386...120,776,097

G

U2 small nuclear RNA auxiliary factor 2

decreases expression

ISO

Benztropine results in decreased expression of U2AF2 protein

NCBI chr 1:77,789,752...77,807,307
Ensembl chr 1:77,789,752...77,807,413

G

ubiquitin-like modifier activating enzyme 2

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of UBA2 protein

NCBI chr 1:95,912,422...95,939,870
Ensembl chr 1:95,912,430...95,939,901

G

ubiquitin associated protein 2-like

decreases expression

ISO

Benztropine results in decreased expression of UBAP2L protein

NCBI chr 2:177,736,378...177,791,746
Ensembl chr 2:177,736,696...177,791,646

G

ubiquitin C

increases expression

ISO

Benztropine results in increased expression of UBC protein

NCBI chr12:36,899,673...36,905,275
Ensembl chr12:36,900,127...36,905,275

G

ubiquilin 2

decreases expression

ISO

Benztropine results in decreased expression of UBQLN2 protein

NCBI chr X:21,228,809...21,232,228
Ensembl chr X:21,229,197...21,232,268

G

ubiquitin C-terminal hydrolase L1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of UCHL1 protein

NCBI chr14:41,838,859...41,849,743
Ensembl chr14:41,838,861...41,849,417

G

ubiquitin C-terminal hydrolase L3

decreases expression

ISO

Benztropine results in decreased expression of UCHL3 protein

NCBI chr15:84,888,847...84,942,095
Ensembl chr15:84,899,806...84,942,095
Ensembl chr 3:84,899,806...84,942,095

G

UDP-glucose 6-dehydrogenase

decreases expression

ISO

Benztropine results in decreased expression of UGDH protein

NCBI chr14:43,202,480...43,226,002
Ensembl chr14:43,202,356...43,226,629

G

unc-45 myosin chaperone B

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of UNC45B protein

NCBI chr10:68,343,011...68,370,683
Ensembl chr10:68,343,014...68,370,980

G

ubiquinol cytochrome c reductase core protein 2

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of UQCRC2 protein

NCBI chr 1:184,599,240...184,629,804
Ensembl chr 1:184,599,212...184,630,946

G

USO1 vesicle transport factor

decreases expression

ISO

Benztropine results in decreased expression of USO1 protein

NCBI chr14:16,150,921...16,216,389
Ensembl chr14:16,150,923...16,216,389

G

ubiquitin specific peptidase 10

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of USP10 protein

NCBI chr19:64,881,255...64,923,522
Ensembl chr19:64,881,315...64,923,519

G

ubiquitin specific peptidase 14

increases expression

ISO

Benztropine results in increased expression of USP14 protein

NCBI chr18:1,292,745...1,330,867
Ensembl chr18:1,292,745...1,330,336

G

UTP18 small subunit processome component

increases expression

ISO

Benztropine results in increased expression of UTP18 protein

NCBI chr10:79,308,785...79,336,241
Ensembl chr10:79,308,787...79,336,197

G

vasodilator-stimulated phosphoprotein

decreases expression

ISO

Benztropine results in decreased expression of VASP protein

NCBI chr 1:88,038,026...88,053,783
Ensembl chr 1:88,038,037...88,058,650

G

tryptophanyl-tRNA synthetase 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of WARS1 protein

NCBI chr 6:133,540,463...133,571,645
Ensembl chr 6:133,539,744...133,571,645

G

WD repeat domain 12

decreases expression

ISO

Benztropine results in decreased expression of WDR12 protein

NCBI chr 9:68,969,547...68,996,811
Ensembl chr 9:68,969,547...68,996,811

G

xin actin-binding repeat containing 2

decreases expression

ISO

Benztropine results in decreased expression of XIRP2 protein

NCBI chr 3:72,534,175...72,621,056
Ensembl chr 3:72,534,146...72,621,056

G

exportin 7

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of XPO7 protein

NCBI chr15:52,151,743...52,237,729
Ensembl chr15:52,151,743...52,237,729

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta

increases expression

ISO

Benztropine results in increased expression of YWHAQ protein

NCBI chr 6:46,664,358...46,694,875
Ensembl chr 6:46,664,358...46,694,875

G

zinc finger and BTB domain containing 42

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of ZBTB42 protein

NCBI chr 6:137,559,622...137,561,750
Ensembl chr 6:137,555,304...137,570,261

G

zinc finger RNA binding protein

decreases expression

ISO

Benztropine results in decreased expression of ZFR protein

NCBI chr 2:62,864,333...62,927,377
Ensembl chr 2:62,864,338...62,929,133

G

zinc finger with KRAB and SCAN domains 7

decreases expression

ISO

Benztropine results in decreased expression of ZKSCAN7 protein

NCBI chr 8:131,379,514...131,397,065
Ensembl chr 8:131,378,013...131,397,065

dextromethorphan

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions
increases phosphorylation

ISO

rostafuroxin inhibits the reaction [Dextromethorphan results in increased phosphorylation of AKT1 protein]

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

EXP

Dizocilpine Maleate inhibits the reaction [Dextromethorphan results in increased expression of BAX protein]; traxoprodil mesylate inhibits the reaction [Dextromethorphan results in increased expression of BAX protein]

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

EXP

traxoprodil mesylate inhibits the reaction [Dextromethorphan results in decreased expression of BCL2 protein]

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

Bcl2-like 1

decreases expression
multiple interactions

EXP

Dextromethorphan results in decreased expression of BCL2L1 protein
Dizocilpine Maleate inhibits the reaction [Dextromethorphan results in decreased expression of BCL2L1 protein]; traxoprodil mesylate inhibits the reaction [Dextromethorphan results in decreased expression of BCL2L1 protein]

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

caspase 3

multiple interactions
increases cleavage

EXP

Dizocilpine Maleate inhibits the reaction [Dextromethorphan results in increased cleavage of CASP3 protein]; traxoprodil mesylate inhibits the reaction [Dextromethorphan results in increased cleavage of CASP3 protein]

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

C-C motif chemokine ligand 2

decreases expression
increases secretion

ISO

Dextromethorphan results in decreased expression of CCL2 protein
Dextromethorphan results in increased secretion of CCL2 protein

PMID:19189960 PMID:32871113

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

cytochrome P450, family 1, subfamily a, polypeptide 1

decreases activity

ISO

Dextromethorphan results in decreased activity of CYP1A1 protein

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily a, polypeptide 2

affects metabolic processing

ISO

CYP1A2 protein affects the metabolism of Dextromethorphan

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

ISO

Dextromethorphan results in decreased activity of CYP1B1 protein

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142

G

cytochrome P450, family 2, subfamily a, polypeptide 3

decreases activity

ISO

Dextromethorphan results in decreased activity of CYP2A4 protein

NCBI chr 1:91,299,584...91,307,650
Ensembl chr 1:91,299,561...91,307,649

G

cytochrome P450, family 2, subfamily b, polypeptide 3

decreases activity

ISO

Dextromethorphan results in decreased activity of CYP2B10 protein

NCBI chr 1:90,780,468...90,859,852

G

cytochrome P450, family 2, subfamily c, polypeptide 13

affects metabolic processing

EXP

CYP2C13 protein affects the metabolism of Dextromethorphan

NCBI chr 1:248,706,787...248,787,239
Ensembl chr 1:248,706,788...248,787,210

G

cytochrome P450, family 2, subfamily C, polypeptide 6

affects metabolic processing

ISO

CYP2C19 protein affects the metabolism of Dextromethorphan

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798

G

cytochrome P450, family 2, subfamily d, polypeptide 2

decreases methylation
affects metabolic processing
multiple interactions
increases metabolic processing

EXP

CYP2D2 protein results in decreased methylation of Dextromethorphan
CYP2D26 protein affects the metabolism of Dextromethorphan
[CYP2D2 protein results in increased metabolism of Dextromethorphan] which results in increased chemical synthesis of Dextrorphan

PMID:11911841 PMID:15879494 PMID:28438436

NCBI chr 7:115,815,212...115,819,281
Ensembl chr 7:115,815,212...115,819,281

G

cytochrome P450, family 2, subfamily d, polypeptide 4

affects metabolic processing
decreases methylation
increases metabolic processing
multiple interactions
decreases activity
increases response to substance

ISO
EXP

CYP2D6 polymorphism affects the metabolism of Dextromethorphan; CYP2D6 protein affects the metabolism of Dextromethorphan; CYP2D6 protein polymorphism affects the metabolism of Dextromethorphan
CYP2D6 protein results in decreased methylation of Dextromethorphan
CYP2D6 mRNA results in increased metabolism of Dextromethorphan; CYP2D6 protein results in increased metabolism of Dextromethorphan
[CYP2D22 protein results in increased metabolism of Dextromethorphan] which results in increased chemical synthesis of Dextrorphan; Ketoconazole inhibits the reaction [CYP2D22 protein results in increased metabolism of Dextromethorphan]
Dextromethorphan results in decreased activity of CYP2D6 protein
Cimetidine inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan]; ozagrel promotes the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan]
[5-bromotryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [5-chlorotryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [5-fluoro-alpha-methyltryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [5-fluoro-alpha-methyltryptamine results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [5-fluorotryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [5-methyltryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [7-methyltryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [CYP2D6 mRNA results in increased metabolism of Dextromethorphan] which results in increased chemical synthesis of Dextrorphan; [CYP2D6 protein results in increased metabolism of Dextromethorphan] which results in increased chemical synthesis of Dextrorphan; [Fluoxetine results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [indopan analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [indopan results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [Methoxydimethyltryptamines analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [N,N-diallyl-5-methoxytryptamine results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [N,N-diisopropyltryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [Paroxetine results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [Tryptamines analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; Nicardipine inhibits the reaction [CYP2D6 protein results in decreased methylation of Dextromethorphan]; notopterol inhibits the reaction [[CYP2D6 protein results in increased metabolism of Dextromethorphan] which results in increased chemical synthesis of Dextrorphan]; notopterol inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan]; Paroxetine inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan]; Plant Extracts inhibits the reaction [CYP2D6 protein affects the metabolism of Dextromethorphan]; Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan]; raubasine inhibits the reaction [CYP2D6 protein affects the metabolism of Dextromethorphan]; Resveratrol inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan]; sarpogrelate inhibits the reaction [CYP2D6 protein results in decreased methylation of Dextromethorphan]; sarpogrelate metabolite inhibits the reaction [CYP2D6 protein results in decreased methylation of Dextromethorphan]; serpentine (alkaloid) inhibits the reaction [CYP2D6 protein affects the metabolism of Dextromethorphan]
CYP2D6 gene polymorphism results in increased susceptibility to Dextromethorphan

PMID:9429230 PMID:9429232 PMID:10911933 PMID:11823760 PMID:12433797 More...

NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases activity

ISO

Dextromethorphan results in decreased activity of CYP2E1 protein

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases methylation
increases oxidation
increases metabolic processing
multiple interactions
affects metabolic processing

ISO

CYP3A4 protein results in decreased methylation of Dextromethorphan
CYP3A4 protein results in increased oxidation of Dextromethorphan
CYP3A4 protein results in increased metabolism of Dextromethorphan
Dextromethorphan inhibits the reaction [[retrorsine co-treated with NADP] results in decreased activity of CYP3A4 protein]
CYP3A4 protein affects the metabolism of Dextromethorphan

PMID:15383492 PMID:15988119 PMID:16595712 PMID:17267297 PMID:19818743

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

affects metabolic processing

EXP

CYP3A23-3A1 protein affects the metabolism of Dextromethorphan

NCBI chr12:14,369,950...14,398,803
Ensembl chr12:14,368,266...14,398,813

G

cytochrome P450, family 3, subfamily a, polypeptide 9

affects metabolic processing
increases oxidation
decreases methylation

ISO

CYP3A5 protein affects the metabolism of Dextromethorphan
CYP3A5 protein results in increased oxidation of Dextromethorphan
CYP3A5 protein results in decreased methylation of Dextromethorphan

PMID:15383492 PMID:15988119

NCBI chr12:21,919,955...21,960,160
Ensembl chr12:21,919,940...21,960,154

G

cytochrome P450, family 46, subfamily a, polypeptide 1

decreases methylation

ISO

CYP46A1 protein results in decreased methylation of Dextromethorphan

NCBI chr 6:133,011,948...133,039,167
Ensembl chr 6:133,011,989...133,041,971

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

EXP
ISO

Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]; Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]; Dizocilpine Maleate inhibits the reaction [Dextromethorphan results in increased expression of FOS protein]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; traxoprodil mesylate inhibits the reaction [Dextromethorphan results in increased expression of FOS protein]
Dextromethorphan inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of FOS]

PMID:15084442 PMID:15723099 PMID:28916251

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

glutamate-cysteine ligase, catalytic subunit

affects expression
multiple interactions

ISO

Dextromethorphan affects the expression of GCLC mRNA
PRKCD protein affects the reaction [Dextromethorphan affects the expression of GCLC mRNA]; rostafuroxin affects the reaction [Dextromethorphan affects the expression of GCLC mRNA]; rottlerin affects the reaction [Dextromethorphan affects the expression of GCLC mRNA]; traxoprodil mesylate affects the reaction [Dextromethorphan affects the expression of GCLC mRNA]

NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893

G

glutamate cysteine ligase, modifier subunit

multiple interactions
affects expression

ISO

PRKCD protein affects the reaction [Dextromethorphan affects the expression of GCLM mRNA]; rostafuroxin affects the reaction [Dextromethorphan affects the expression of GCLM mRNA]; rottlerin affects the reaction [Dextromethorphan affects the expression of GCLM mRNA]; traxoprodil mesylate affects the reaction [Dextromethorphan affects the expression of GCLM mRNA]

NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003

G

glutamic--pyruvic transaminase

multiple interactions

ISO

Dextromethorphan inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] results in increased activity of GPT protein]

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

glutamate ionotropic receptor NMDA type subunit 1

increases expression

EXP

Dextromethorphan results in increased expression of GRIN1 protein

NCBI chr 3:28,501,836...28,528,754
Ensembl chr 3:28,501,836...28,528,754

G

glutamate ionotropic receptor NMDA type subunit 2A

increases expression

EXP

Dextromethorphan results in increased expression of GRIN2A protein

NCBI chr10:6,136,458...6,560,003
Ensembl chr10:6,138,037...6,551,378

G

glutamate ionotropic receptor NMDA type subunit 2B

multiple interactions
increases expression

EXP
ISO

Dizocilpine Maleate inhibits the reaction [Dextromethorphan results in increased expression of GRIN2B protein]; traxoprodil mesylate inhibits the reaction [Dextromethorphan results in increased expression of GRIN2B protein]
Dextromethorphan promotes the reaction [PRKCD protein modified form binds to GRIN2B protein]; rostafuroxin inhibits the reaction [Dextromethorphan promotes the reaction [PRKCD protein modified form binds to GRIN2B protein]]; rostafuroxin inhibits the reaction [Dextromethorphan results in increased expression of GRIN2B protein]; rottlerin inhibits the reaction [Dextromethorphan promotes the reaction [PRKCD protein modified form binds to GRIN2B protein]]; traxoprodil mesylate inhibits the reaction [Dextromethorphan promotes the reaction [PRKCD protein modified form binds to GRIN2B protein]]; traxoprodil mesylate inhibits the reaction [Dextromethorphan results in increased expression of GRIN2B protein]

PMID:28916251 PMID:34740715

NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:170,322,617...170,773,570

G

hexosaminidase subunit beta

multiple interactions
increases secretion

ISO

MRGPRX2 protein affects the reaction [Dextromethorphan results in increased secretion of HEXB protein]

NCBI chr 2:30,218,608...30,238,771
Ensembl chr 2:30,218,608...30,238,771

G

interleukin 10

decreases expression

ISO

Dextromethorphan results in decreased expression of IL10 protein

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 6

decreases expression

ISO

Dextromethorphan results in decreased expression of IL6 protein

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

EXP
ISO

Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]; Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]]
Dextromethorphan inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of JUN]

PMID:15084442 PMID:15723099

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

potassium voltage-gated channel subfamily H member 2

decreases activity

ISO

Dextromethorphan results in decreased activity of KCNH2 protein

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

G

KIT proto-oncogene receptor tyrosine kinase

affects response to substance

ISO

KIT protein affects the susceptibility to Dextromethorphan

NCBI chr14:32,901,615...32,978,895
Ensembl chr14:32,903,033...32,978,812

G

mitogen activated protein kinase 1

increases phosphorylation
multiple interactions

ISO

Dextromethorphan results in increased phosphorylation of MAPK1 protein
rostafuroxin inhibits the reaction [Dextromethorphan results in increased phosphorylation of MAPK1 protein]

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation

ISO

rostafuroxin inhibits the reaction [Dextromethorphan results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

MAS related GPR family member X2

affects response to substance
multiple interactions
affects binding

ISO

MRGPRX2 protein affects the susceptibility to Dextromethorphan
MRGPRX2 protein affects the reaction [Dextromethorphan results in increased secretion of HEXB protein]
Dextromethorphan binds to MRGPRX2 protein

NCBI chr 1:107,252,467...107,271,809

G

N-acetyltransferase 2

affects metabolic processing

ISO

NAT2 protein affects the metabolism of Dextromethorphan

NCBI chr16:26,974,874...27,005,191
Ensembl chr16:26,974,601...26,976,304

G

NFE2 like bZIP transcription factor 2

multiple interactions

ISO

[PRKCD protein affects the susceptibility to Dextromethorphan] which affects the activity of and affects the localization of NFE2L2 protein; [rostafuroxin co-treated with Dextromethorphan] results in increased activity of and affects the localization of NFE2L2 protein; [rottlerin co-treated with Dextromethorphan] results in increased activity of and affects the localization of NFE2L2 protein; [traxoprodil mesylate co-treated with Dextromethorphan] results in increased activity of and affects the localization of NFE2L2 protein; Buthionine Sulfoximine inhibits the reaction [Dextromethorphan results in increased activity of NFE2L2 protein]; Dextromethorphan results in increased activity of and affects the localization of NFE2L2 protein

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

opioid receptor, delta 1

multiple interactions
affects binding

EXP

[Dextromethorphan binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Dextromethorphan binds to OPRD1 protein] which results in decreased uptake of Serotonin

NCBI chr 5:149,590,244...149,624,999
Ensembl chr 5:149,590,244...149,624,999

G

opioid receptor, kappa 1

affects binding
multiple interactions

EXP

Dextromethorphan binds to OPRK1 protein
[Dextromethorphan binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Dextromethorphan binds to OPRK1 protein] which results in decreased uptake of Serotonin

NCBI chr 5:18,657,866...18,675,671
Ensembl chr 5:18,657,871...18,675,671

G

opioid receptor, mu 1

multiple interactions
affects binding

EXP

[Dextromethorphan binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Dextromethorphan binds to OPRM1 protein] which results in decreased uptake of Serotonin

NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:45,565,371...45,638,756

G

protein kinase C, delta

multiple interactions
affects response to substance

ISO

[PRKCD protein affects the susceptibility to Dextromethorphan] which affects the activity of and affects the localization of NFE2L2 protein; Dextromethorphan promotes the reaction [PRKCD protein modified form binds to GRIN2B protein]; Dextromethorphan results in increased expression of and results in increased phosphorylation of PRKCD protein; PRKCD protein affects the reaction [Dextromethorphan affects the expression of GCLC mRNA]; PRKCD protein affects the reaction [Dextromethorphan affects the expression of GCLM mRNA]; rostafuroxin inhibits the reaction [Dextromethorphan promotes the reaction [PRKCD protein modified form binds to GRIN2B protein]]; rostafuroxin inhibits the reaction [Dextromethorphan results in increased phosphorylation of PRKCD protein]; rottlerin inhibits the reaction [Dextromethorphan promotes the reaction [PRKCD protein modified form binds to GRIN2B protein]]; rottlerin inhibits the reaction [Dextromethorphan results in increased phosphorylation of PRKCD protein]; traxoprodil mesylate inhibits the reaction [Dextromethorphan promotes the reaction [PRKCD protein modified form binds to GRIN2B protein]]; traxoprodil mesylate inhibits the reaction [Dextromethorphan results in increased phosphorylation of PRKCD protein]

NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,775,681...5,805,839

G

prostaglandin-endoperoxide synthase 2

multiple interactions

ISO

Dextromethorphan inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
affects activity

ISO

Buthionine Sulfoximine affects the reaction [Dextromethorphan affects the activity of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

sigma non-opioid intracellular receptor 1

multiple interactions
affects binding

EXP

SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]]
Dextromethorphan binds to SIGMAR1 protein

NCBI chr 5:61,700,021...61,702,799
Ensembl chr 5:61,700,021...61,702,855

G

solute carrier family 22 member 2

multiple interactions

ISO

Dextromethorphan inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

G

solute carrier family 6 member 4

multiple interactions

EXP

Dextromethorphan inhibits the reaction [Excitatory Amino Acid Agonists results in decreased expression of SLC6A4 protein]

NCBI chr10:62,322,688...62,357,060
Ensembl chr10:62,324,254...62,357,056

G

synuclein alpha

multiple interactions

EXP

Dextromethorphan promotes the reaction [zolmitriptan inhibits the reaction [Reserpine results in increased expression of SNCA protein]]

NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:91,026,474...91,126,315

G

sorbitol dehydrogenase

multiple interactions

ISO

Dextromethorphan inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] results in increased activity of SORD protein]

NCBI chr 3:129,638,282...129,669,727
Ensembl chr 3:129,638,302...129,686,100

G

transforming growth factor alpha

multiple interactions

ISO

Dextromethorphan inhibits the reaction [Lipopolysaccharides results in increased secretion of TGFA]

NCBI chr 4:120,175,549...120,258,342
Ensembl chr 4:120,175,593...120,258,339

G

tumor necrosis factor

decreases expression
increases secretion
multiple interactions

ISO

Dextromethorphan results in decreased expression of TNF protein
Dextromethorphan results in increased secretion of TNF protein
Dextromethorphan inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] results in increased expression of TNF protein]; Dextromethorphan inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]

PMID:19189960 PMID:30822415 PMID:32871113

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

xanthine dehydrogenase

affects metabolic processing

ISO

XDH protein affects the metabolism of Dextromethorphan

NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:27,282,057...27,344,350

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

butyrylcholinesterase

decreases activity

ISO

Dimenhydrinate results in decreased activity of BCHE protein

NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760

G

solute carrier family 22 member 2

multiple interactions

ISO

Dimenhydrinate inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

diphenhydramine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

autophagy related 5

affects response to substance

ISO

ATG5 protein affects the susceptibility to Diphenhydramine

NCBI chr20:49,380,835...49,471,826
Ensembl chr20:49,380,813...49,471,821

G

butyrylcholinesterase

multiple interactions
decreases activity

ISO

Protons affects the reaction [Diphenhydramine results in decreased activity of BCHE protein]

NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760

G

bone morphogenetic protein 6

decreases expression

ISO

Diphenhydramine results in decreased expression of BMP6 mRNA

NCBI chr17:26,523,704...26,785,558
Ensembl chr17:26,523,704...26,675,261

G

epiregulin

decreases expression

ISO

Diphenhydramine results in decreased expression of EREG mRNA

NCBI chr14:17,311,485...17,325,260
Ensembl chr14:17,311,485...17,325,260

G

coagulation factor III, tissue factor

multiple interactions

ISO

Diphenhydramine inhibits the reaction [Histamine results in increased expression of F3]

NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:212,511,680...212,523,369

G

G protein subunit alpha i1

increases response to substance

ISO

GNAI1 results in increased susceptibility to Diphenhydramine

NCBI chr 4:17,706,061...17,790,176
Ensembl chr 4:17,706,025...17,789,198

G

G protein subunit alpha i2

increases response to substance

ISO

GNAI2 results in increased susceptibility to Diphenhydramine

NCBI chr 8:117,167,045...117,187,652
Ensembl chr 8:117,167,045...117,187,622

G

histamine receptor H 1

multiple interactions

ISO
EXP

Diphenhydramine binds to and results in decreased activity of HRH1 protein; Diphenhydramine binds to and results in increased activity of HRH1 protein; Diphenhydramine inhibits the reaction [Pyrilamine binds to HRH1 protein]; HRH1 protein promotes the reaction [Diphenhydramine results in decreased susceptibility to CXCL8 protein]
[Diphenhydramine results in decreased activity of HRH1 protein] which results in decreased susceptibility to Erythromycin

PMID:1912125 PMID:2419744 PMID:2461127 PMID:7522859 PMID:9609743 More...

NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:149,120,039...149,208,248

G

interleukin 1 beta

increases expression
decreases expression

ISO

Diphenhydramine results in increased expression of IL1B mRNA
Diphenhydramine results in decreased expression of IL1B mRNA

PMID:28138970 PMID:32816093

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 24

decreases expression

ISO

Diphenhydramine results in decreased expression of IL24 mRNA

NCBI chr13:44,905,362...44,910,760
Ensembl chr13:44,905,363...44,910,760

G

interleukin 6

multiple interactions

ISO

Diphenhydramine inhibits the reaction [Histamine results in increased expression of IL6 protein]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

mitogen-activated protein kinase 8

increases activity

ISO

Diphenhydramine results in increased activity of MAPK8

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

nuclear receptor subfamily 1, group I, member 3

multiple interactions

ISO

[Diphenhydramine co-treated with PK 11195] binds to and results in increased activity of NR1I3 protein alternative form

NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370

G

phospholipase A2 group 4A

multiple interactions

ISO

Diphenhydramine inhibits the reaction [Histamine results in increased expression of PLA2G4A mRNA]

NCBI chr13:64,427,921...64,572,352
Ensembl chr13:64,427,916...64,589,641

G

prostaglandin-endoperoxide synthase 2

decreases expression

ISO

Diphenhydramine results in decreased expression of PTGS2 mRNA

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

solute carrier family 22 member 1

multiple interactions

ISO

Diphenhydramine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]

NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:50,624,377...50,651,436

G

solute carrier family 22 member 2

multiple interactions

ISO

Diphenhydramine inhibits the reaction [SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Diphenhydramine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

PMID:16263091 PMID:21599003

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

G

solute carrier family 22 member 3

multiple interactions

ISO

Diphenhydramine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]

NCBI chr 1:50,783,218...50,872,358
Ensembl chr 1:50,783,218...50,872,353

G

solute carrier family 22 member 5

multiple interactions

ISO

Diphenhydramine affects the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]; Diphenhydramine inhibits the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]

NCBI chr10:38,509,072...38,536,240
Ensembl chr10:38,509,072...38,536,077

G

solute carrier family 7 member 11

decreases expression

ISO

Diphenhydramine results in decreased expression of SLC7A11 mRNA

NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695

G

secretory leukocyte peptidase inhibitor

increases expression

ISO

Diphenhydramine results in increased expression of SLPI mRNA

NCBI chr 3:173,501,573...173,503,822
Ensembl chr 3:173,501,573...173,503,822

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adrenoceptor beta 1

multiple interactions

ISO

Harmaline affects the reaction [Epinephrine results in increased activity of ADRB1 protein]

NCBI chr 1:265,777,103...265,780,114
Ensembl chr 1:265,766,079...265,849,237

G

adrenoceptor beta 2

multiple interactions

ISO

Harmaline inhibits the reaction [Epinephrine results in increased activity of ADRB2 protein]

NCBI chr18:57,912,760...57,914,802
Ensembl chr18:57,911,348...57,914,803

G

C-C motif chemokine ligand 2

multiple interactions

ISO

Harmaline inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 protein]

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

cadherin 1

increases expression

ISO

Harmaline results in increased expression of CDH1 protein

NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
decreases activity
decreases stability

ISO

[Cycloheximide co-treated with Harmaline] results in decreased expression of CYP1A1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Cycloheximide co-treated with Harmaline] results in decreased expression of CYP1A1 protein]; Harmaline inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; Harmaline inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A1 protein]; Harmaline inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
Harmaline results in decreased activity of CYP1A1 protein
Harmaline results in decreased stability of CYP1A1 protein

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

endoglin

decreases expression
multiple interactions

ISO

Harmaline results in decreased expression of ENG mRNA
Doxorubicin promotes the reaction [Harmaline results in decreased expression of ENG mRNA]

NCBI chr 3:36,332,190...36,370,324
Ensembl chr 3:36,326,202...36,370,933

G

interferon gamma

increases secretion

ISO

Harmaline results in increased secretion of IFNG protein

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

interleukin 1 beta

multiple interactions

ISO

Harmaline inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Harmaline inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 4

affects secretion
multiple interactions

ISO

Harmaline affects the secretion of IL4 protein
Doxorubicin affects the reaction [Harmaline results in decreased secretion of IL4 protein]

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549

G

kinase insert domain receptor

multiple interactions
decreases expression

ISO

Doxorubicin promotes the reaction [Harmaline results in decreased expression of KDR mRNA]

NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,572,049...32,615,192

G

monoamine oxidase A

decreases activity

EXP
ISO

Harmaline results in decreased activity of MAOA protein

PMID:15178694 PMID:24373881 PMID:28302559

NCBI chr X:8,615,239...8,681,372
Ensembl chr X:8,615,239...8,682,631

G

marker of proliferation Ki-67

decreases expression

ISO

Harmaline results in decreased expression of MKI67 protein

NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593

G

matrix metallopeptidase 2

decreases expression

ISO

Harmaline results in decreased expression of MMP2 protein

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

nuclear factor kappa B subunit 1

multiple interactions

ISO

Harmaline inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Harmaline inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of NFKB1 protein]

PMID:12065299 PMID:12107048

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

prostaglandin-endoperoxide synthase 2

multiple interactions
decreases expression

ISO

Doxorubicin promotes the reaction [Harmaline results in decreased expression of PTGS2 mRNA]

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO

Harmaline inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Harmaline inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of RELA protein]

PMID:12065299 PMID:12107048

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

vascular endothelial growth factor A

multiple interactions
decreases expression

ISO

Doxorubicin promotes the reaction [Harmaline results in decreased expression of VEGFA mRNA]
Harmaline results in decreased expression of VEGFA mRNA; Harmaline results in decreased expression of VEGFA protein

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

potassium voltage-gated channel subfamily H member 2

decreases activity

ISO

Ibogaine results in decreased activity of KCNH2 protein

PMID:23707769 PMID:24307198

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

G

sodium voltage-gated channel alpha subunit 5

decreases activity

ISO

Ibogaine results in decreased activity of SCN5A protein

NCBI chr 8:128,098,613...128,196,515
Ensembl chr 8:128,098,613...128,196,470

G

SEC24 homolog D, COPII coat complex component

increases response to substance

ISO

SEC24D protein results in increased susceptibility to Ibogaine

NCBI chr 2:214,103,138...214,211,155
Ensembl chr 2:214,103,190...214,211,144

G

solute carrier family 6 member 3

multiple interactions
increases expression

ISO

Ibogaine inhibits the reaction [SLC6A3 protein mutant form results in decreased import of Dopamine]; Ibogaine promotes the reaction [SLC6A3 protein results in increased import of Dopamine]
Ibogaine results in increased expression of SLC6A3 protein

NCBI chr 1:31,537,990...31,578,962
Ensembl chr 1:31,537,990...31,578,962

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

increases export

ISO

ABCB1 protein results in increased export of mirtazapine

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

actin alpha 2, smooth muscle

multiple interactions

ISO

mirtazapine inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein]

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503

G

AKT serine/threonine kinase 1

decreases phosphorylation
multiple interactions

EXP

Mirtazapine results in decreased phosphorylation of AKT1 protein
Ethanol promotes the reaction [Mirtazapine results in decreased phosphorylation of AKT1 protein]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in decreased phosphorylation of AKT1 protein]]; HMGB1 protein affects the reaction [Mirtazapine results in decreased phosphorylation of AKT1 protein]

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

autophagy related 7

multiple interactions
increases expression

EXP
ISO

Ethanol promotes the reaction [Mirtazapine results in increased expression of ATG7 mRNA]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of ATG7 mRNA]]; HMGB1 protein affects the reaction [Mirtazapine results in increased expression of ATG7 mRNA]

NCBI chr 4:149,390,000...149,597,534
Ensembl chr 4:149,391,390...149,598,319

G

BCL2 associated X, apoptosis regulator

multiple interactions

ISO

Mirtazapine inhibits the reaction [phenylhydrazine results in increased expression of BAX mRNA]; Mirtazapine promotes the reaction [Quercetin inhibits the reaction [phenylhydrazine results in increased expression of BAX mRNA]]; Quercetin promotes the reaction [Mirtazapine inhibits the reaction [phenylhydrazine results in increased expression of BAX mRNA]]

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

multiple interactions

ISO

Mirtazapine inhibits the reaction [phenylhydrazine results in decreased expression of BCL2 mRNA]; Mirtazapine promotes the reaction [Quercetin inhibits the reaction [phenylhydrazine results in decreased expression of BCL2 mRNA]]; Quercetin promotes the reaction [Mirtazapine inhibits the reaction [phenylhydrazine results in decreased expression of BCL2 mRNA]]

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

beclin 1

multiple interactions
increases expression

ISO
EXP

Ethanol promotes the reaction [Mirtazapine results in increased expression of BECN1 protein]
3-methyladenine inhibits the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of BECN1 protein]]; 3-methyladenine inhibits the reaction [Mirtazapine results in increased expression of BECN1 protein]; Ethanol promotes the reaction [Mirtazapine results in increased expression of BECN1 protein]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of BECN1 protein]]; HMGB1 protein affects the reaction [Mirtazapine results in increased expression of BECN1 protein]

NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,731,650...86,747,002

G

caspase 3

multiple interactions

ISO

Mirtazapine inhibits the reaction [phenylhydrazine results in increased expression of CASP3 mRNA]; Mirtazapine promotes the reaction [Quercetin inhibits the reaction [phenylhydrazine results in increased expression of CASP3 mRNA]]; Quercetin promotes the reaction [Mirtazapine inhibits the reaction [phenylhydrazine results in increased expression of CASP3 mRNA]]

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

catalase

multiple interactions

EXP

mirtazapine inhibits the reaction [Indomethacin results in increased activity of CAT protein]

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

collagen type I alpha 1 chain

multiple interactions
increases expression

ISO
EXP

Ethanol promotes the reaction [Mirtazapine results in increased expression of COL1A1 mRNA]
3-methyladenine inhibits the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of COL1A1 mRNA]]; 3-methyladenine inhibits the reaction [Mirtazapine results in increased expression of COL1A1 mRNA]; Ethanol promotes the reaction [Mirtazapine results in increased expression of COL1A1 mRNA]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of COL1A1 mRNA]]; HMGB1 protein affects the reaction [Mirtazapine results in increased expression of COL1A1 mRNA]

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460

G

dopamine receptor D1

increases expression

EXP

mirtazapine results in increased expression of DRD1 mRNA

NCBI chr17:10,545,488...10,550,029
Ensembl chr17:10,545,111...10,567,166

G

dopamine receptor D2

multiple interactions

EXP

mirtazapine inhibits the reaction [Quinpirole binds to DRD2 protein]

NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:58,605,403...58,669,339

G

dopamine receptor D3

multiple interactions

EXP

mirtazapine inhibits the reaction [Quinpirole binds to DRD3 protein]

NCBI chr11:70,385,586...70,437,793
Ensembl chr11:70,385,586...70,446,760

G

follicle stimulating hormone subunit beta

multiple interactions

ISO

Mirtazapine inhibits the reaction [phenylhydrazine results in decreased expression of FSHB protein]; Mirtazapine promotes the reaction [Quercetin inhibits the reaction [phenylhydrazine results in decreased expression of FSHB protein]]; Quercetin promotes the reaction [Mirtazapine inhibits the reaction [phenylhydrazine results in decreased expression of FSHB protein]]

NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:114,003,262...114,007,072

G

glutamic--pyruvic transaminase

multiple interactions
increases expression

ISO

Ethanol promotes the reaction [Mirtazapine results in increased expression of GPT protein]

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

high mobility group box 1

multiple interactions
increases expression

EXP

Ethanol promotes the reaction [Mirtazapine results in increased expression of HMGB1 protein]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in decreased expression of LAMP1 protein]]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in decreased phosphorylation of AKT1 protein]]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in decreased phosphorylation of MTOR protein]]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of ATG7 mRNA]]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of BECN1 protein]]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of COL1A1 mRNA]]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of NPPB mRNA]]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of PIK3C3 protein]]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of SQSTM1 protein]]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of TGFB1 mRNA]]; HMGB1 protein affects the reaction [Mirtazapine results in decreased expression of LAMP1 protein]; HMGB1 protein affects the reaction [Mirtazapine results in decreased phosphorylation of AKT1 protein]; HMGB1 protein affects the reaction [Mirtazapine results in decreased phosphorylation of MTOR protein]; HMGB1 protein affects the reaction [Mirtazapine results in increased expression of ATG7 mRNA]; HMGB1 protein affects the reaction [Mirtazapine results in increased expression of BECN1 protein]; HMGB1 protein affects the reaction [Mirtazapine results in increased expression of COL1A1 mRNA]; HMGB1 protein affects the reaction [Mirtazapine results in increased expression of NPPB mRNA]; HMGB1 protein affects the reaction [Mirtazapine results in increased expression of PIK3C3 protein]; HMGB1 protein affects the reaction [Mirtazapine results in increased expression of SQSTM1 protein]; HMGB1 protein affects the reaction [Mirtazapine results in increased expression of TGFB1 mRNA]

NCBI chr12:11,009,236...11,015,941
Ensembl chr16:39,039,050...39,041,327
Ensembl chr12:39,039,050...39,041,327

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

increases expression

ISO

mirtazapine results in increased expression of HMGCS1 mRNA

NCBI chr 2:53,379,457...53,399,807
Ensembl chr 2:53,382,643...53,399,802

G

5-hydroxytryptamine receptor 2C

multiple interactions
increases expression

ISO

6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline inhibits the reaction [mirtazapine results in increased expression of HTR2C protein]; mirtazapine binds to and affects the activity of HTR2C protein

NCBI chr X:115,453,190...115,682,325
Ensembl chr X:115,452,842...115,682,324

G

interleukin 1 beta

multiple interactions

EXP

Mirtazapine inhibits the reaction [Cadmium results in increased expression of IL1B protein]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

multiple interactions

EXP

Mirtazapine inhibits the reaction [Cadmium results in increased expression of IL6 protein]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

potassium inwardly-rectifying channel, subfamily J, member 3

multiple interactions

ISO

mirtazapine affects the activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA]; mirtazapine affects the activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA]

NCBI chr 3:60,353,990...60,518,110
Ensembl chr 3:60,354,146...60,518,104

G

potassium inwardly-rectifying channel, subfamily J, member 5

multiple interactions

ISO

mirtazapine affects the activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA]

NCBI chr 8:38,981,598...39,011,197
Ensembl chr 8:38,983,034...39,011,101

G

potassium inwardly-rectifying channel, subfamily J, member 6

multiple interactions

ISO

mirtazapine affects the activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA]

NCBI chr11:47,531,312...47,778,348
Ensembl chr11:47,531,312...47,778,348

G

lysosomal-associated membrane protein 1

multiple interactions
decreases expression

EXP

Ethanol promotes the reaction [Mirtazapine results in decreased expression of LAMP1 protein]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in decreased expression of LAMP1 protein]]; HMGB1 protein affects the reaction [Mirtazapine results in decreased expression of LAMP1 protein]

NCBI chr16:83,058,131...83,082,843
Ensembl chr16:83,058,385...83,075,159

G

luteinizing hormone subunit beta

multiple interactions

ISO

Mirtazapine inhibits the reaction [phenylhydrazine results in decreased expression of LHB protein]; Quercetin promotes the reaction [Mirtazapine inhibits the reaction [phenylhydrazine results in decreased expression of LHB protein]]

NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:105,037,457...105,038,445

G

myeloperoxidase

multiple interactions

EXP

mirtazapine inhibits the reaction [Indomethacin results in increased activity of MPO protein]

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

mechanistic target of rapamycin kinase

decreases phosphorylation
multiple interactions

EXP

Mirtazapine results in decreased phosphorylation of MTOR protein
Ethanol promotes the reaction [Mirtazapine results in decreased phosphorylation of MTOR protein]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in decreased phosphorylation of MTOR protein]]; HMGB1 protein affects the reaction [Mirtazapine results in decreased phosphorylation of MTOR protein]

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435

G

NFE2 like bZIP transcription factor 2

increases expression

EXP

Mirtazapine results in increased expression of NFE2L2 protein

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

NADPH oxidase 1

multiple interactions

ISO

mirtazapine inhibits the reaction [Thioacetamide results in increased expression of NOX1 protein]

NCBI chr X:101,572,338...101,625,571
Ensembl chr X:101,572,340...101,595,520

G

natriuretic peptide B

increases expression
multiple interactions

ISO
EXP

Mirtazapine results in increased expression of NPPB mRNA
Ethanol promotes the reaction [Mirtazapine results in increased expression of NPPB mRNA]
3-methyladenine inhibits the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of NPPB mRNA]]; 3-methyladenine inhibits the reaction [Mirtazapine results in increased expression of NPPB mRNA]; Ethanol promotes the reaction [Mirtazapine results in increased expression of NPPB mRNA]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of NPPB mRNA]]; HMGB1 protein affects the reaction [Mirtazapine results in increased expression of NPPB mRNA]

NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:163,699,839...163,701,310

G

phosphatidylinositol 3-kinase, catalytic subunit type 3

increases expression
multiple interactions

EXP

Mirtazapine results in increased expression of PIK3C3 protein
3-methyladenine inhibits the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of PIK3C3 protein]]; 3-methyladenine inhibits the reaction [Mirtazapine results in increased expression of PIK3C3 protein]; Ethanol promotes the reaction [Mirtazapine results in increased expression of PIK3C3 protein]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of PIK3C3 protein]]; HMGB1 protein affects the reaction [Mirtazapine results in increased expression of PIK3C3 protein]

NCBI chr18:22,119,677...22,203,546
Ensembl chr18:22,119,792...22,203,539

G

prolactin

increases expression

ISO

mirtazapine results in increased expression of PRL protein

NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217

G

RELA proto-oncogene, NF-kB subunit

decreases expression

EXP

Mirtazapine results in decreased expression of RELA protein

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

stearoyl-CoA desaturase

increases expression

ISO

mirtazapine results in increased expression of SCD mRNA

NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:253,218,970...253,231,785

G

solute carrier family 22 member 2

multiple interactions

ISO

mirtazapine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

G

solute carrier family 2 member 4

increases expression

ISO

mirtazapine results in increased expression of SLC2A4 mRNA

NCBI chr10:55,164,721...55,170,289
Ensembl chr10:55,164,721...55,170,270

G

solute carrier family 2 member 5

increases expression

ISO

mirtazapine results in increased expression of SLC2A5 mRNA

NCBI chr 5:165,857,412...165,892,928
Ensembl chr 5:165,866,172...165,894,038

G

SMAD family member 3

multiple interactions

ISO

mirtazapine inhibits the reaction [Thioacetamide results in increased expression of SMAD3 protein modified form]

NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:73,024,760...73,132,324

G

sequestosome 1

increases expression
multiple interactions

EXP
ISO

Mirtazapine results in increased expression of SQSTM1 protein
Ethanol promotes the reaction [Mirtazapine results in increased expression of SQSTM1 protein]
3-methyladenine inhibits the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of SQSTM1 protein]]; 3-methyladenine inhibits the reaction [Mirtazapine results in increased expression of SQSTM1 protein]; Ethanol promotes the reaction [Mirtazapine results in increased expression of SQSTM1 protein]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of SQSTM1 protein]]; HMGB1 protein affects the reaction [Mirtazapine results in increased expression of SQSTM1 protein]

NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750

G

sterol regulatory element binding transcription factor 1

multiple interactions

ISO

mirtazapine results in increased cleavage of and results in increased activity of SREBF1 protein

NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164

G

transforming growth factor, beta 1

multiple interactions
increases expression

ISO
EXP

Ethanol promotes the reaction [Mirtazapine results in increased expression of TGFB1 mRNA]; Mirtazapine inhibits the reaction [Thioacetamide results in increased expression of TGFB1 protein]
Ethanol promotes the reaction [Mirtazapine results in increased expression of TGFB1 mRNA]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of TGFB1 mRNA]]; HMGB1 protein affects the reaction [Mirtazapine results in increased expression of TGFB1 mRNA]

PMID:28623179 PMID:35066094

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

toll-like receptor 4

decreases expression

EXP

Mirtazapine results in decreased expression of TLR4 protein

NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007

G

tumor necrosis factor

multiple interactions

EXP

Mirtazapine inhibits the reaction [Cadmium results in increased expression of TNF protein]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

brain-derived neurotrophic factor

multiple interactions

EXP

Muscimol inhibits the reaction [decamethrin results in increased expression of BDNF exon]

NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657

G

caspase 3

multiple interactions

ISO

Muscimol inhibits the reaction [Ethanol results in increased cleavage of CASP3 protein]

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

cholinergic receptor nicotinic alpha 5 subunit

multiple interactions

ISO

Muscimol binds to and results in increased activity of [CHRNA5 protein co-treated with CHRNB1 protein]

NCBI chr 8:64,265,879...64,294,233
Ensembl chr 8:64,265,879...64,294,233

G

cholinergic receptor nicotinic beta 1 subunit

multiple interactions

ISO

Muscimol binds to and results in increased activity of [CHRNA5 protein co-treated with CHRNB1 protein]

NCBI chr10:54,999,943...55,015,137
Ensembl chr10:55,002,788...55,015,107

G

endoplasmic reticulum to nucleus signaling 1

multiple interactions

ISO

Muscimol inhibits the reaction [Ethanol results in increased phosphorylation of ERN1 protein]

NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,830,428...91,920,791

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

EXP

Muscimol inhibits the reaction [Cocaine results in increased expression of FOS protein]

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

follicle stimulating hormone subunit beta

multiple interactions
decreases expression

EXP

Muscimol inhibits the reaction [Diethylhexyl Phthalate results in increased expression of FSHB protein]
Muscimol results in decreased expression of FSHB protein

NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:114,003,262...114,007,072

G

gamma-aminobutyric acid type A receptor subunit alpha 1

multiple interactions
affects binding

ISO

GABRA1 protein affects the reaction [Muscimol results in increased uptake of Chlorides]
Muscimol binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]
2,6-diisopropyl-4-(3-(3-methyl-3H-diazirin-3-yl)propyl)phenol promotes the reaction [Muscimol binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Propofol affects the reaction [Muscimol binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]

PMID:12490572 PMID:22029276

NCBI chr10:27,096,731...27,152,563
Ensembl chr10:27,096,740...27,152,442

G

gamma-aminobutyric acid type A receptor subunit beta1

affects binding

EXP

Muscimol binds to GABRB1 protein

NCBI chr14:36,434,339...36,917,920
Ensembl chr14:36,434,352...36,902,893

G

gamma-aminobutyric acid type A receptor subunit beta 2

multiple interactions
affects binding

ISO
EXP

GABRB2 protein affects the reaction [Muscimol results in increased uptake of Chlorides]
alphaxalone promotes the reaction [Muscimol binds to GABRB2 protein]; Pentobarbital affects the reaction [GABRB2 protein binds to Muscimol]; Pentobarbital promotes the reaction [Muscimol binds to GABRB2 protein]
GABRB2 protein binds to Muscimol; Muscimol binds to GABRB2 protein

PMID:8397295 PMID:10591412 PMID:12490572

NCBI chr10:27,438,127...27,657,680
Ensembl chr10:27,438,238...27,655,171

G

gamma-aminobutyric acid type A receptor subunit beta 3

multiple interactions
affects binding

EXP
ISO

alphaxalone promotes the reaction [Muscimol binds to GABRB3 protein]; Pentobarbital promotes the reaction [Muscimol binds to GABRB3 protein]
2,6-diisopropyl-4-(3-(3-methyl-3H-diazirin-3-yl)propyl)phenol promotes the reaction [Muscimol binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Propofol affects the reaction [Muscimol binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]

PMID:8397295 PMID:22029276

NCBI chr 1:117,602,772...117,838,230
Ensembl chr 1:117,431,842...117,836,725

G

gamma-aminobutyric acid type A receptor subunit gamma 2

multiple interactions
affects binding

ISO

2,6-diisopropyl-4-(3-(3-methyl-3H-diazirin-3-yl)propyl)phenol promotes the reaction [Muscimol binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Propofol affects the reaction [Muscimol binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]

NCBI chr10:26,876,926...26,965,523
Ensembl chr10:26,876,926...26,965,523

G

gamma-aminobutyric acid type A receptor subunit rho3

increases activity

EXP

Muscimol results in increased activity of GABRR3 protein

NCBI chr11:54,372,017...54,424,466
Ensembl chr11:54,372,017...54,424,466

G

gonadotropin releasing hormone 1

multiple interactions

EXP

Muscimol affects the reaction [bisphenol A affects the secretion of GNRH1 protein]

NCBI chr15:46,147,878...46,152,086
Ensembl chr15:46,148,301...46,148,977
Ensembl chr15:46,148,301...46,148,977

G

glutamic--pyruvic transaminase

multiple interactions

ISO

Muscimol inhibits the reaction [Ethanol results in increased activity of GPT protein]

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

luteinizing hormone subunit beta

decreases expression

EXP

Muscimol results in decreased expression of LHB protein

NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:105,037,457...105,038,445

G

mitogen-activated protein kinase kinase kinase 5

multiple interactions

ISO

Muscimol inhibits the reaction [Ethanol results in increased expression of MAP3K5 protein]

NCBI chr 1:16,505,387...16,723,899
Ensembl chr 1:16,505,596...16,723,898

G

mitogen activated protein kinase 1

multiple interactions

EXP

Muscimol promotes the reaction [methyl tert-butyl ether results in decreased phosphorylation of MAPK1 protein]

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

multiple interactions

EXP

Muscimol promotes the reaction [methyl tert-butyl ether results in decreased phosphorylation of MAPK3 protein]

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 8

multiple interactions

ISO

Muscimol inhibits the reaction [Ethanol results in increased expression of MAPK8 protein]

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

proopiomelanocortin

multiple interactions
decreases expression

EXP

Muscimol promotes the reaction [Pentobarbital results in decreased expression of POMC mRNA]
Muscimol results in decreased expression of POMC mRNA

NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:32,659,346...32,665,173

G

synapsin I

decreases expression

EXP

Muscimol results in decreased expression of SYN1 protein

NCBI chr X:3,725,745...3,780,940
Ensembl chr X:3,725,714...3,780,938

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	20874
role	20844
application	20572
pharmaceutical	20359
drug	20359
central nervous system drug	16774
psychotropic drug	15626
oneirogen	525
atropine	99
benzatropine +	329
dextromethorphan +	52
diphenhydramine +	21
harmaline	17
ibogaine	4
ibogamine	0
mirtazapine	43
muscimol	22
salvinorin A	0

paths to the root