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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ryanodine receptor antagonist
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Accession:CHEBI:146223 term browser browse the term


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dantrolene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RYR1 ryanodine receptor 1 decreases activity
multiple interactions		 EXP Dantrolene results in decreased activity of RYR1 protein
5'-adenylyl (beta,gamma-methylene)diphosphonate affects the reaction [Dantrolene results in decreased activity of RYR1 protein]; [Dantrolene inhibits the reaction [Calcium results in increased activity of RYR1 protein]] which results in decreased secretion of Calcium; Dantrolene inhibits the reaction [Caffeine promotes the reaction [Ryanodine binds to RYR1 protein mutant form]]; Dantrolene inhibits the reaction [Caffeine promotes the reaction [Ryanodine binds to RYR1 protein]]; Dantrolene inhibits the reaction [Caffeine results in increased activity of RYR1 protein mutant form]; Dantrolene inhibits the reaction [Caffeine results in increased activity of RYR1 protein]; Dantrolene inhibits the reaction [Calcium results in increased activity of RYR1 protein]; Dantrolene inhibits the reaction [Ryanodine binds to RYR1 protein mutant form]; Dantrolene inhibits the reaction [Ryanodine binds to RYR1 protein]; Dantrolene inhibits the reaction [Strontium promotes the reaction [Ryanodine binds to RYR1 protein]]		 CTD PMID:11278295 NCBI chr 6:47,339,759...47,458,457
Ensembl chr 6:47,343,768...47,458,458 		JBrowse link
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  CHEBI ontology 5164
    role 5131
      biological role 5131
        biophysical role 209
          membrane transport modulator 124
            calcium channel modulator 96
              ryanodine receptor modulator 8
                ryanodine receptor antagonist 1
                  dantrolene 1
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