ryanodine receptor antagonist - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	ryanodine receptor antagonist	go back to main search page
Accession:	CHEBI:146223	browse the term

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Rat (53) Mouse (54) Human (53) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (1) Green Monkey (0) Naked Mole-rat (0) All
Genes (53)

dantrolene

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily G member 2 (JR blood group)

affects transport

ABCG2 protein affects the transport of Dantrolene

NCBI chr 4:88,090,264...88,231,626
Ensembl chr 4:88,090,150...88,231,628

G

angiotensin converting enzyme 2

increases expression

Dantrolene results in increased expression of ACE2 mRNA

NCBI chr X:15,518,197...15,607,211
Ensembl chr X:15,494,566...15,607,236

G

activating transcription factor 4

decreases expression
multiple interactions

Dantrolene results in decreased expression of ATF4 protein
Dantrolene affects the reaction [perfluorooctanoic acid results in increased expression of ATF4 protein]; Dantrolene inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]; Dantrolene promotes the reaction [Thapsigargin results in increased expression of ATF4 mRNA]

PMID:15921666 PMID:32578922

NCBI chr22:39,520,559...39,522,686
Ensembl chr22:39,519,695...39,522,686

G

BCL2 associated X, apoptosis regulator

multiple interactions

Dantrolene inhibits the reaction [Halothane results in increased expression of BAX mRNA]

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

BCL2 apoptosis regulator

increases expression

Dantrolene results in increased expression of BCL2 protein

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

BCL2 like 11

multiple interactions

Dantrolene inhibits the reaction [Halothane results in increased expression of BCL2L11 mRNA]

NCBI chr 2:111,120,914...111,168,445
Ensembl chr 2:111,119,378...111,168,444

G

brain derived neurotrophic factor

multiple interactions

Dantrolene inhibits the reaction [Oxygen deficiency results in increased secretion of BDNF protein]

NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058

G

calpain 1

decreases expression

Dantrolene results in decreased expression of CAPN1 mRNA; Dantrolene results in decreased expression of CAPN1 protein

NCBI chr11:65,181,373...65,212,006
Ensembl chr11:65,180,566...65,212,006

G

calpain 2

decreases expression

Dantrolene results in decreased expression of CAPN2 mRNA; Dantrolene results in decreased expression of CAPN2 protein

NCBI chr 1:223,701,597...223,776,018
Ensembl chr 1:223,701,593...223,776,018

G

calpain 3

decreases expression

Dantrolene results in decreased expression of CAPN3 mRNA; Dantrolene results in decreased expression of CAPN3 protein

NCBI chr15:42,359,501...42,412,317
Ensembl chr15:42,359,498...42,412,949

G

caspase 3

multiple interactions

Dantrolene inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]
Dantrolene inhibits the reaction [Indomethacin results in increased activity of CASP3 protein]

PMID:17079870 PMID:23022152

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

caspase 9

multiple interactions

Dantrolene inhibits the reaction [Indomethacin results in increased activity of CASP9 protein]

NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534

G

C-C motif chemokine ligand 2

decreases expression

Dantrolene results in decreased expression of CCL2 mRNA

NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208

G

C-C motif chemokine ligand 5

affects expression

Dantrolene affects the expression of CCL5 protein

NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793

G

C-X-C motif chemokine ligand 2

multiple interactions

Dantrolene inhibits the reaction [Halothane results in increased expression of CXCL2 mRNA]

NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196

G

cytochrome P450 family 1 subfamily A member 1

multiple interactions

Dantrolene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]

NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536

G

cytochrome P450 family 1 subfamily A member 2

multiple interactions

Dantrolene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]

NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607

G

DNA damage inducible transcript 3

decreases phosphorylation
multiple interactions

Dantrolene results in decreased phosphorylation of DDIT3 protein
Dantrolene inhibits the reaction [Halothane results in increased expression of DDIT3 mRNA]; Dantrolene promotes the reaction [perfluorooctanoic acid results in increased expression of DDIT3 mRNA]; Dantrolene promotes the reaction [perfluorooctanoic acid results in increased expression of DDIT3 protein]

PMID:15921666 PMID:32578922 PMID:32795494

NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737

G

endothelin 1

decreases activity

Dantrolene results in decreased activity of EDN1 protein

NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194

G

eukaryotic translation initiation factor 2 alpha kinase 3

decreases phosphorylation

Dantrolene results in decreased phosphorylation of EIF2AK3 protein

NCBI chr 2:88,556,741...88,628,145
Ensembl chr 2:88,556,741...88,691,518

G

eukaryotic translation initiation factor 2 subunit alpha

decreases phosphorylation
multiple interactions

Dantrolene results in decreased phosphorylation of EIF2S1 protein
Dantrolene inhibits the reaction [tributyltin results in increased phosphorylation of EIF2S1 protein]

PMID:15921666 PMID:23743301

NCBI chr14:67,360,328...67,386,516
Ensembl chr14:67,360,328...67,386,516

G

FKBP prolyl isomerase 1A

multiple interactions

Dantrolene inhibits the reaction [Halothane results in increased expression of FKBP1A mRNA]

NCBI chr20:1,368,978...1,393,054
Ensembl chr20:1,368,977...1,393,164

G

FKBP prolyl isomerase 1B

multiple interactions

Dantrolene inhibits the reaction [Halothane results in increased expression of FKBP1B mRNA]

NCBI chr 2:24,033,206...24,063,681
Ensembl chr 2:24,049,701...24,063,681

G

glial fibrillary acidic protein

multiple interactions

Dantrolene inhibits the reaction [diphenylditelluride results in decreased phosphorylation of GFAP protein]; Dantrolene inhibits the reaction [diphenylditelluride results in increased phosphorylation of GFAP protein]

PMID:21863293 PMID:21879721

NCBI chr17:44,903,159...44,915,500
Ensembl chr17:44,903,159...44,916,937

G

glutamic--pyruvic transaminase

multiple interactions

Dantrolene inhibits the reaction [Halothane results in increased expression of GPT protein]

NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174

G

heme oxygenase 1

multiple interactions

Dantrolene inhibits the reaction [Halothane results in increased expression of HMOX1 mRNA]

NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214

G

homer scaffold protein 1

multiple interactions

Dantrolene inhibits the reaction [Halothane results in increased expression of HOMER1 mRNA]

NCBI chr 5:79,372,636...79,514,134
Ensembl chr 5:79,372,636...79,514,134

G

heat shock protein family A (Hsp70) member 5

multiple interactions

Dantrolene inhibits the reaction [tributyltin results in increased expression of HSPA5 protein]

NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382

G

interferon gamma

multiple interactions

Dantrolene inhibits the reaction [taurolithocholic acid 3-sulfate results in increased expression of IFNG mRNA]

NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740

G

insulin like growth factor 1

decreases response to substance

Dantrolene results in decreased susceptibility to IGF1 protein

NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744

G

insulin like growth factor 2

decreases response to substance

Dantrolene results in decreased susceptibility to IGF2 protein

NCBI chr11:2,129,117...2,149,566
Ensembl chr11:2,129,112...2,158,391

G

interleukin 10

multiple interactions
affects expression

Dantrolene inhibits the reaction [[chlorocresol results in increased activity of RYR1 protein] inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]]
Dantrolene affects the expression of IL10 protein

PMID:17707769 PMID:25051504

NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541

G

interleukin 1 beta

affects expression
multiple interactions

Dantrolene affects the expression of IL1B mRNA
Dantrolene inhibits the reaction [Halothane results in increased expression of IL1B mRNA]

PMID:25051504 PMID:32795494

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

interleukin 6

multiple interactions

Dantrolene inhibits the reaction [taurolithocholic acid 3-sulfate results in increased expression of IL6 mRNA]

NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002

G

potassium voltage-gated channel subfamily H member 2

decreases activity

Dantrolene results in decreased activity of KCNH2 protein

NCBI chr 7:150,944,961...150,978,321
Ensembl chr 7:150,944,961...150,978,321

G

potassium inwardly rectifying channel subfamily J member 11

multiple interactions

Dantrolene inhibits the reaction [KCNJ11 protein mutant form results in increased abundance of Calcium]

NCBI chr11:17,385,248...17,389,346
Ensembl chr11:17,365,172...17,389,331

G

leptin

decreases expression

Dantrolene results in decreased expression of LEP protein

NCBI chr 7:128,241,278...128,257,629
Ensembl chr 7:128,241,278...128,257,629

G

myocyte enhancer factor 2A

multiple interactions

Dantrolene inhibits the reaction [Caffeine results in increased expression of MEF2A mRNA]; Dantrolene inhibits the reaction [Caffeine results in increased expression of MEF2A protein]

NCBI chr15:99,565,417...99,716,488
Ensembl chr15:99,565,417...99,716,488

G

myocyte enhancer factor 2C

multiple interactions

Dantrolene inhibits the reaction [Caffeine results in increased expression of MEF2C mRNA]; Dantrolene inhibits the reaction [Caffeine results in increased expression of MEF2C protein]

NCBI chr 5:88,717,117...88,904,105
Ensembl chr 5:88,717,117...88,904,257

G

myosin heavy chain 7

multiple interactions

Dantrolene inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]

NCBI chr14:23,412,740...23,435,660
Ensembl chr14:23,412,740...23,435,660

G

neurofilament light chain

multiple interactions

Dantrolene inhibits the reaction [diphenylditelluride results in decreased phosphorylation of NEFL protein]; Dantrolene inhibits the reaction [diphenylditelluride results in increased phosphorylation of NEFL protein]

PMID:21863293 PMID:21879721

NCBI chr 8:24,950,955...24,956,612
Ensembl chr 8:24,950,955...24,956,721

G

neurofilament medium chain

multiple interactions

Dantrolene inhibits the reaction [diphenylditelluride results in decreased phosphorylation of NEFM protein]; Dantrolene inhibits the reaction [diphenylditelluride results in increased phosphorylation of NEFM protein]

PMID:21863293 PMID:21879721

NCBI chr 8:24,913,761...24,919,093
Ensembl chr 8:24,913,758...24,919,098

G

natriuretic peptide A

multiple interactions

Dantrolene inhibits the reaction [Caffeine results in increased expression of NPPA mRNA]

NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345

G

natriuretic peptide B

multiple interactions

Dantrolene inhibits the reaction [Caffeine results in increased expression of NPPB mRNA]

NCBI chr 1:11,857,464...11,858,945
Ensembl chr 1:11,857,464...11,858,945

G

ryanodine receptor 1

multiple interactions

Dantrolene inhibits the reaction [[chlorocresol results in increased activity of RYR1 protein] inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]]; Dantrolene inhibits the reaction [[chlorocresol results in increased activity of RYR1 protein] which results in increased transport of Calcium]

NCBI chr19:38,433,691...38,587,564
Ensembl chr19:38,433,691...38,595,273

G

ryanodine receptor 2

multiple interactions

Dantrolene inhibits the reaction [Caffeine promotes the reaction [RYR2 protein results in increased secretion of Calcium]]

NCBI chr 1:237,042,184...237,833,988
Ensembl chr 1:237,042,184...237,833,988

G

S100 calcium binding protein A8

multiple interactions

Dantrolene inhibits the reaction [Halothane results in increased expression of S100A8 mRNA]

NCBI chr 1:153,390,032...153,422,583
Ensembl chr 1:153,390,032...153,391,073

G

S100 calcium binding protein A9

multiple interactions

Dantrolene inhibits the reaction [Halothane results in increased expression of S100A9 mRNA]

NCBI chr 1:153,357,854...153,361,023
Ensembl chr 1:153,357,854...153,361,023

G

steroidogenic acute regulatory protein

multiple interactions

Dantrolene inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of STAR mRNA]

NCBI chr 8:38,142,700...38,150,952
Ensembl chr 8:38,142,700...38,150,992

G

tumor necrosis factor

decreases expression
multiple interactions

Dantrolene results in decreased expression of TNF protein
Dantrolene inhibits the reaction [Halothane results in increased expression of TNF mRNA]

PMID:11236903 PMID:32795494

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

vascular cell adhesion molecule 1

multiple interactions

Dantrolene inhibits the reaction [Halothane results in increased expression of VCAM1 mRNA]

NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045

G

vimentin

multiple interactions

Dantrolene inhibits the reaction [diphenylditelluride results in decreased phosphorylation of VIM protein]; Dantrolene inhibits the reaction [diphenylditelluride results in increased phosphorylation of VIM protein]

PMID:21863293 PMID:21879721

NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593

G

X-box binding protein 1

multiple interactions

Dantrolene inhibits the reaction [perfluorooctanoic acid results in increased expression of XBP1 mRNA alternative form]; Dantrolene inhibits the reaction [Thapsigargin results in increased expression of XBP1 mRNA alternative form]

NCBI chr22:28,794,560...28,800,569
Ensembl chr22:28,794,555...28,800,597

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	26503
role	26325
biological role	26304
biophysical role	14851
membrane transport modulator	14655
calcium channel modulator	9988
ryanodine receptor modulator	3856
ryanodine receptor antagonist	53
dantrolene	53

paths to the root