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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:3-acetyldeoxynivalenol
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Accession:CHEBI:146195 term browser browse the term
Definition:A trichothecene mycotoxin that is deoxynivalenol acetylated on the oxygen at C-3. A skin and eye irritant, along with its 15-acetyl regioisomer and its parent deoxynivalenol it is considered among the most commonly and widely distributed cereal contaminants.
Synonyms:exact_synonym: 7alpha,15-dihydroxy-8-oxo-12,13-epoxytrichothec-9-en-3alpha-yl acetate
 related_synonym: (3alpha,7alpha)-3-(acetyloxy)-12,13-epoxy-7,15-dihydroxytrichothec-9-en-8-one;   15-ADON;   3-(acetyloxy)-12,13-epoxy-7alpha,15alpha-dihydroxytrichothec-9-en-8-one;   3-acetyl-DON;   3-acetyl-deoxynivalenol;   Formula=C17H22O7;   InChI=1S/C17H22O7/c1-8-4-11-16(6-18,13(21)12(8)20)15(3)5-10(23-9(2)19)14(24-11)17(15)7-22-17/h4,10-11,13-14,18,21H,5-7H2,1-3H3/t10-,11-,13-,14-,15-,16-,17+/m1/s1;   InChIKey=ADFIQZBYNGPCGY-HTJQZXIKSA-N;   SMILES=[H][C@@]12O[C@]3([H])C=C(C)C(=O)[C@@H](O)[C@]3(CO)[C@@](C)(C[C@H]1OC(C)=O)[C@]21CO1
 xref: AGR:IND45257683;   CAS:50722-38-8;   FooDB:FDB014986;   HMDB:HMDB0036137
 xref_mesh: MESH:C043247
 xref: MetaCyc:CPD-18419;   PMID:11510664;   PMID:14620907;   PMID:16521158;   PMID:21204935;   PMID:22016651;   PMID:22367943;   PMID:22465835;   PMID:22997060;   PMID:23025486;   PMID:23470877;   PMID:23605932;   PMID:23792671;   PMID:24385417;   PMID:25772259;   PMID:26274975;   PMID:26343882;   PMID:27131905;   PMID:27483321;   PMID:29914486;   PMID:30806951;   PMID:31442898;   PMID:32454357


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3-acetyldeoxynivalenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor decreases activity
multiple interactions		 ISO 3-acetyldeoxynivalenol results in decreased activity of AR protein
[15-acetyldeoxynivalenol co-treated with 3-acetyldeoxynivalenol co-treated with deoxynivalenol co-treated with zearalenol co-treated with Zearalenone] results in decreased activity of AR protein; [15-acetyldeoxynivalenol co-treated with 3-acetyldeoxynivalenol co-treated with deoxynivalenol] results in decreased activity of AR protein		 CTD PMID:27481073 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Atf4 activating transcription factor 4 increases expression
multiple interactions		 ISO 3-acetyldeoxynivalenol results in increased expression of ATF4 mRNA
4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of ATF4 mRNA]		 CTD PMID:35413383 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Atf6 activating transcription factor 6 increases expression
multiple interactions		 ISO 3-acetyldeoxynivalenol results in increased expression of ATF6 mRNA
4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of ATF6 mRNA]		 CTD PMID:20682335 PMID:35413383 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
G Cck cholecystokinin increases expression ISO 3-acetyldeoxynivalenol results in increased expression of CCK protein CTD PMID:24385417 NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
multiple interactions		 ISO 3-acetyldeoxynivalenol results in increased expression of CCL2 mRNA
3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of CCL2 protein; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of CCL2 protein]; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of CCL2 mRNA]		 CTD PMID:24793808 PMID:35413383 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl7 C-C motif chemokine ligand 7 increases expression ISO 3-acetyldeoxynivalenol results in increased expression of CCL7 mRNA CTD PMID:24793808 NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303 		JBrowse link
G Csf1 colony stimulating factor 1 increases expression
multiple interactions		 ISO 3-acetyldeoxynivalenol results in increased expression of CSF1 mRNA
4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of CSF1 mRNA]		 CTD PMID:35413383 NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704 		JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO 3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of CSF2 protein; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of CSF2 protein] CTD PMID:35413383 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Csf3 colony stimulating factor 3 multiple interactions
increases expression		 ISO 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of CSF3 mRNA] CTD PMID:35413383 NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO 3-acetyldeoxynivalenol results in increased expression of CXCL2 mRNA CTD PMID:24793808 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression		 ISO 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of DDIT3 mRNA] CTD PMID:35413383 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases phosphorylation ISO 3-acetyldeoxynivalenol results in increased phosphorylation of EIF2A protein CTD PMID:20682335 NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases expression ISO 3-acetyldeoxynivalenol results in increased expression of EIF2AK3 mRNA CTD PMID:35413383 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases expression
multiple interactions		 ISO 3-acetyldeoxynivalenol results in increased expression of EIF2S1 mRNA
4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of EIF2S1 mRNA]		 CTD PMID:35413383 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases expression
multiple interactions		 ISO 3-acetyldeoxynivalenol results in increased expression of ERN1 mRNA
4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of ERN1 mRNA]		 CTD PMID:20682335 PMID:35413383 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 decreases expression
multiple interactions
increases expression		 ISO 3-acetyldeoxynivalenol results in decreased expression of HSPA5 mRNA
4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of HSPA5 mRNA]		 CTD PMID:20682335 PMID:35413383 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Ifnb1 interferon beta 1 increases expression
multiple interactions		 ISO 3-acetyldeoxynivalenol results in increased expression of IFNB1 mRNA
3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of IFNB1 protein; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of IFNB1 protein]; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of IFNB1 mRNA]		 CTD PMID:35413383 NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523 		JBrowse link
G Ifng interferon gamma multiple interactions
increases expression		 ISO 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of IFNG mRNA] CTD PMID:35413383 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 multiple interactions
increases expression		 ISO 3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of IL10 protein; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of IL10 protein]; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of IL10 mRNA] CTD PMID:35413383 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il17a interleukin 17A increases expression
multiple interactions		 ISO 3-acetyldeoxynivalenol results in increased expression of IL17A mRNA
3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of IL17A protein; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of IL17A protein]; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of IL17A mRNA]		 CTD PMID:35413383 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il1a interleukin 1 alpha increases expression
multiple interactions		 ISO 3-acetyldeoxynivalenol results in increased expression of IL1A mRNA
3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of IL1A protein; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of IL1A protein]; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of IL1A mRNA]		 CTD PMID:35413383 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions		 ISO 3-acetyldeoxynivalenol results in increased expression of IL1B mRNA
3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of IL1B protein; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of IL1B protein]; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of IL1B mRNA]		 CTD PMID:24793808 PMID:35413383 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 affects secretion
increases expression		 ISO 3-acetyldeoxynivalenol affects the secretion of IL2 protein
3-acetyldeoxynivalenol results in increased expression of IL2 mRNA		 CTD PMID:8560498 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il4 interleukin 4 affects secretion ISO 3-acetyldeoxynivalenol affects the secretion of IL4 protein CTD PMID:8560498 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il5 interleukin 5 affects secretion ISO 3-acetyldeoxynivalenol affects the secretion of IL5 protein CTD PMID:8560498 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions		 ISO 3-acetyldeoxynivalenol results in increased expression of IL6 mRNA
3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of IL6 protein; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of IL6 protein]; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of IL6 mRNA]		 CTD PMID:24793808 PMID:35413383 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases expression		 ISO 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of MAPK8 mRNA] CTD PMID:35413383 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mpo myeloperoxidase multiple interactions
increases secretion		 ISO 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased secretion of MPO protein] CTD PMID:35413383 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases activity ISO 3-acetyldeoxynivalenol results in decreased activity of PPARG protein CTD PMID:27481073 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO 3-acetyldeoxynivalenol results in increased expression of PTGS2 mRNA CTD PMID:14514436 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Thrb thyroid hormone receptor beta decreases activity
multiple interactions		 ISO 3-acetyldeoxynivalenol results in decreased activity of THRB protein
[15-acetyldeoxynivalenol co-treated with 3-acetyldeoxynivalenol co-treated with deoxynivalenol co-treated with zearalenol co-treated with Zearalenone] results in decreased activity of THRB protein		 CTD PMID:27481073 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 ISO 3-acetyldeoxynivalenol results in increased expression of TNF mRNA
3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of TNF protein; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of TNF protein]; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of TNF mRNA]		 CTD PMID:24793808 PMID:35413383 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Xbp1 X-box binding protein 1 increases expression
multiple interactions		 ISO 3-acetyldeoxynivalenol results in increased expression of XBP1 mRNA
4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of XBP1 mRNA]		 CTD PMID:35413383 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    role 19868
      biological role 19866
        epitope 7035
          3-acetyldeoxynivalenol 33
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19771
                          organic molecular entity 19771
                            organic molecule 19724
                              organic cyclic compound 19515
                                organic heterocyclic compound 18890
                                  organic heteromonocyclic compound 17820
                                    saturated organic heteromonocyclic parent 11315
                                      oxirane 11296
                                        epoxide 11295
                                          trichothecene 1534
                                            deoxynivalenol 878
                                              3-acetyldeoxynivalenol 33
paths to the root