macropolylide - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	macropolylide	go back to main search page
Accession:	CHEBI:145555	browse the term
Definition:	Macrolides (macrocyclic lactones) in which the macrocyclic ring contains more than one ester linkage. Macropolylides include macrodiolides, macrotriolides, macrotetrolides and macropentolides, each containing di-, tri-, tetra-, and penta- ester linkages, respectively, in one macrocyclic ring. Macrocyclic lactones containing nitrogen in their skeletons (azamacrolides and macrolide lactams) and also containing oxazole or thiazole in their skeletons are known in nature.
Synonyms:	related_synonym:	macropolylides

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Rat (760 ) Mouse (757 ) Human (780 ) Chinchilla (0 ) Bonobo (0 ) Dog (0 ) Squirrel (0 ) Pig (3 ) Green Monkey (0) Naked Mole-rat (0 ) All
Genes (760)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

decreases activity

ISO

antimycin results in decreased activity of ABCB11 protein

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581

G

angiotensinogen

multiple interactions

EXP

antimycin inhibits the reaction [AGT protein results in increased degradation of NFKBIA protein]

NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944

G

AKT serine/threonine kinase 1

increases phosphorylation

ISO

antimycin results in increased phosphorylation of AKT1 protein

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

Bcl2-like 1

increases expression

ISO

antimycin results in increased expression of BCL2L1 protein

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

caspase 3

multiple interactions

ISO

antimycin results in increased cleavage of and results in increased activity of CASP3 protein

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

mitogen-activated protein kinase 8

decreases phosphorylation

ISO

antimycin results in decreased phosphorylation of MAPK8 protein

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

mitogen-activated protein kinase 9

decreases phosphorylation

ISO

antimycin results in decreased phosphorylation of MAPK9 protein

NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228

G

NFKB inhibitor alpha

multiple interactions

EXP

antimycin inhibits the reaction [AGT protein results in increased degradation of NFKBIA protein]

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

paired box 3

decreases expression

ISO

antimycin results in decreased expression of PAX3 mRNA

NCBI chr 9:87,015,960...87,112,531
Ensembl chr 9:87,016,999...87,124,141

G

phospholipase C, gamma 1

increases phosphorylation

ISO

antimycin results in increased phosphorylation of PLCG1 protein

NCBI chr 3:169,805,299...169,836,040
Ensembl chr 3:169,804,846...169,836,050

G

protein kinase AMP-activated catalytic subunit alpha 1

increases phosphorylation

ISO

antimycin results in increased phosphorylation of PRKAA1 protein

NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:55,967,351...56,003,450

G

ribosomal protein S6 kinase B1

decreases phosphorylation
multiple interactions

ISO

antimycin results in decreased phosphorylation of RPS6KB1 protein
oxophenylarsine inhibits the reaction [antimycin results in decreased phosphorylation of RPS6KB1 protein]

NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,815,614...71,865,238

G

superoxide dismutase 2

decreases response to substance

ISO

SOD2 protein results in decreased susceptibility to antimycin

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

RIKEN cDNA 4933427D14 gene like

decreases expression

ISO

Antimycin A results in decreased expression of KIAA0753 mRNA

NCBI chr10:57,282,433...57,331,259
Ensembl chr10:57,281,439...57,331,259

G

ATP binding cassette subfamily B member 6

increases expression

ISO

Antimycin A results in increased expression of ABCB6 mRNA

NCBI chr 9:84,117,222...84,125,939
Ensembl chr 9:84,117,220...84,125,526

G

abhydrolase domain containing 6, acylglycerol lipase

decreases expression

ISO

Antimycin A results in decreased expression of ABHD6 mRNA

NCBI chr15:19,289,967...19,337,500
Ensembl chr15:19,289,969...19,337,193

G

acyl-CoA dehydrogenase, very long chain

decreases expression

ISO

Antimycin A results in decreased expression of ACADVL mRNA

NCBI chr10:55,231,558...55,236,786
Ensembl chr10:55,231,440...55,236,750

G

acyl-CoA oxidase 2

increases expression

ISO

Antimycin A results in increased expression of ACOX2 mRNA

NCBI chr15:19,090,820...19,122,392
Ensembl chr15:19,090,926...19,122,392

G

ADAM metallopeptidase domain 10

decreases expression

ISO

Antimycin A results in decreased expression of ADAM10 mRNA

NCBI chr 8:80,226,862...80,358,728
Ensembl chr 8:80,226,674...80,361,600

G

adrenomedullin

increases expression

ISO

Antimycin A results in increased expression of ADM mRNA

NCBI chr 1:174,164,178...174,182,372
Ensembl chr 1:174,178,773...174,182,371

G

apoptosis enhancing nuclease

increases expression

ISO

Antimycin A results in increased expression of AEN mRNA

NCBI chr 1:142,224,499...142,233,902
Ensembl chr 1:142,224,493...142,233,898

G

activator of Hsp90 ATPase activity 1

increases expression

ISO

Antimycin A results in increased expression of AHSA1 mRNA

NCBI chr 6:112,644,287...112,652,290
Ensembl chr 6:112,644,479...112,655,595

G

aldo-keto reductase family 1 member B1

decreases expression

ISO

Antimycin A results in decreased expression of AKR1B1 mRNA

NCBI chr 4:63,899,222...63,913,315
Ensembl chr 4:63,899,222...63,913,315

G

aldo-keto reductase family 1, member B7

increases expression

ISO

Antimycin A results in increased expression of AKR1B7 mRNA

NCBI chr 4:64,043,901...64,083,751
Ensembl chr 4:64,020,686...64,064,909

G

aldo-keto reductase family 7, member A2

decreases expression

ISO

Antimycin A results in decreased expression of AKR7A2 mRNA

NCBI chr 5:156,835,589...156,844,127
Ensembl chr 5:156,835,551...156,844,109

G

AKT serine/threonine kinase 1

multiple interactions
decreases expression
decreases activity

ISO

Luteolin inhibits the reaction [Antimycin A results in decreased activity of AKT1 protein]
Antimycin A results in decreased expression of AKT1 mRNA

PMID:21466842 PMID:21782929 PMID:33512557

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

5'-aminolevulinate synthase 1

decreases expression

ISO

Antimycin A results in decreased expression of ALAS1 mRNA

NCBI chr 8:115,755,238...115,768,642
Ensembl chr 8:115,755,238...115,768,642

G

aldehyde dehydrogenase 1 family, member L2

increases expression

ISO

Antimycin A results in increased expression of ALDH1L2 mRNA

NCBI chr 7:22,141,872...22,193,403
Ensembl chr 7:22,141,842...22,193,398

G

aldehyde dehydrogenase 2 family member

decreases expression

ISO

Antimycin A results in decreased expression of ALDH2 mRNA

NCBI chr12:40,610,244...40,643,220
Ensembl chr12:40,610,224...40,643,219

G

aldehyde dehydrogenase 7 family, member A1

decreases expression

ISO

Antimycin A results in decreased expression of ALDH7A1 mRNA

NCBI chr18:52,208,035...52,240,293
Ensembl chr18:52,204,161...52,240,467

G

aldolase, fructose-bisphosphate A

increases expression

ISO

Antimycin A results in increased expression of ALDOA mRNA

NCBI chr 1:190,832,820...190,838,021
Ensembl chr 1:190,832,820...190,838,211

G

APC membrane recruitment protein 1

decreases expression

ISO

Antimycin A results in decreased expression of AMER1 mRNA

NCBI chr X:64,310,492...64,326,377
Ensembl chr X:64,300,953...64,326,332

G

angiopoietin-like 6

increases expression

ISO

Antimycin A results in increased expression of ANGPTL6 mRNA

NCBI chr 8:27,689,804...27,696,172
Ensembl chr 8:27,689,806...27,696,111

G

anillin, actin binding protein

increases expression

ISO

Antimycin A results in increased expression of ANLN mRNA

NCBI chr 8:29,134,222...29,197,513
Ensembl chr 8:29,134,222...29,197,513

G

acidic nuclear phosphoprotein 32 family member E

increases expression

ISO

Antimycin A results in increased expression of ANP32E mRNA

NCBI chr 2:186,161,520...186,177,984
Ensembl chr 2:186,161,532...186,177,986

G

annexin A2

increases expression

ISO

Antimycin A results in increased expression of ANXA2 mRNA

NCBI chr 8:78,986,252...79,022,638
Ensembl chr 8:78,986,242...79,022,631

G

adaptor related protein complex 3 subunit mu 1

decreases expression

ISO

Antimycin A results in decreased expression of AP3M1 mRNA

NCBI chr15:3,285,591...3,314,139
Ensembl chr15:3,295,444...3,313,104

G

amyloid beta precursor like protein 1

decreases expression

ISO

Antimycin A results in decreased expression of APLP1 mRNA

NCBI chr 1:94,824,330...94,834,705
Ensembl chr 1:94,824,072...94,834,610

G

Rho GTPase activating protein 8

increases expression

ISO

Antimycin A results in increased expression of ARHGAP8 mRNA

NCBI chr 7:117,723,512...117,782,031
Ensembl chr 7:117,730,578...117,782,030

G

ARF like GTPase 4D

increases expression

ISO

Antimycin A results in increased expression of ARL4D mRNA

NCBI chr10:87,092,276...87,103,079
Ensembl chr10:87,077,523...87,106,199

G

arrestin domain containing 4

decreases expression

ISO

Antimycin A results in decreased expression of ARRDC4 mRNA

NCBI chr 1:131,779,436...131,793,438
Ensembl chr 1:131,779,437...131,793,565

G

activating signal cointegrator 1 complex subunit 3

increases expression

ISO

Antimycin A results in increased expression of ASCC3 mRNA

NCBI chr20:55,089,430...55,372,374
Ensembl chr20:55,255,503...55,372,374

G

asparagine synthetase (glutamine-hydrolyzing)

increases expression

ISO

Antimycin A results in increased expression of ASNS mRNA

NCBI chr 4:36,752,061...36,769,970
Ensembl chr 4:36,751,802...36,776,050

G

argininosuccinate synthase 1

increases expression

ISO

Antimycin A results in increased expression of ASS1 mRNA

NCBI chr 3:35,144,765...35,194,632
Ensembl chr 3:35,144,999...35,194,627

G

activating transcription factor 3

increases expression

ISO

Antimycin A results in increased expression of ATF3 mRNA

NCBI chr13:105,274,103...105,331,653
Ensembl chr13:105,282,440...105,295,750

G

activating transcription factor 4

increases expression

ISO

Antimycin A results in increased expression of ATF4 mRNA

NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739

G

activating transcription factor 5

increases expression

ISO

Antimycin A results in increased expression of ATF5 mRNA

NCBI chr 1:104,432,094...104,437,611
Ensembl chr 1:104,432,094...104,436,183

G

autophagy related 13

multiple interactions

ISO

Antimycin A promotes the reaction [ATG13 protein results in increased expression of ULK1 protein]; ATG13 protein promotes the reaction [Antimycin A results in increased expression of ULK1 protein]

NCBI chr 3:98,102,831...98,136,741
Ensembl chr 3:98,101,552...98,136,743

G

ATM serine/threonine kinase

decreases expression

ISO

Antimycin A results in decreased expression of ATM mRNA

NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:62,727,291...62,828,629

G

ATM interactor

decreases expression

ISO

Antimycin A results in decreased expression of ATMIN mRNA

NCBI chr19:61,905,343...61,922,443
Ensembl chr19:61,905,144...61,922,443

G

ATPase phospholipid transporting 11B (putative)

decreases expression

ISO

Antimycin A results in decreased expression of ATP11B mRNA

NCBI chr 2:118,585,348...118,691,076
Ensembl chr 2:120,513,552...120,619,249

G

ATPase phospholipid transporting 11C

decreases expression

ISO

Antimycin A results in decreased expression of ATP11C mRNA

NCBI chr X:143,600,763...143,788,407
Ensembl chr X:143,600,767...143,788,432

G

ATP synthase F1 subunit gamma

decreases expression

ISO

Antimycin A results in decreased expression of ATP5F1C mRNA

NCBI chr17:73,333,584...73,355,872
Ensembl chr17:73,333,588...73,383,073

G

ATPase H+ transporting V0 subunit e1

decreases expression

ISO

Antimycin A results in decreased expression of ATP6V0E1 mRNA

NCBI chr10:16,984,084...17,007,156
Ensembl chr10:16,984,084...17,028,858

G

ATPase H+ transporting V1 subunit B2

decreases expression

ISO

Antimycin A results in decreased expression of ATP6V1B2 mRNA

NCBI chr16:25,384,254...25,408,388
Ensembl chr16:25,384,257...25,408,839

G

ATPase H+ transporting V1 subunit H

multiple interactions

ISO

[PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of ATP6V1H mRNA

NCBI chr 5:19,176,849...19,282,516
Ensembl chr 5:19,176,849...19,282,516

G

ATRX, chromatin remodeler

increases expression

ISO

Antimycin A results in increased expression of ATRX mRNA

NCBI chr X:74,916,548...75,062,880
Ensembl chr X:74,916,548...75,062,880

G

aurora kinase B

increases expression

ISO

Antimycin A results in increased expression of AURKB mRNA

NCBI chr10:54,243,116...54,249,675
Ensembl chr10:54,242,850...54,252,285

G

beta-2 microglobulin

increases expression

ISO

Antimycin A results in increased expression of B2M mRNA

NCBI chr 3:129,549,236...129,555,354
Ensembl chr 3:129,549,318...129,555,356

G

Beta-1,3-galactosyltransferase 6

decreases expression

ISO

Antimycin A results in decreased expression of B3GALT6 mRNA

NCBI chr 5:171,866,428...171,868,564
Ensembl chr 5:171,864,094...171,874,789

G

BAG cochaperone 3

increases expression

ISO

Antimycin A results in increased expression of BAG3 mRNA

NCBI chr 1:192,533,460...192,557,281
Ensembl chr 1:192,475,828...192,557,280

G

BMP and activin membrane-bound inhibitor

increases expression

ISO

Antimycin A results in increased expression of BAMBI mRNA

NCBI chr17:58,816,438...58,821,003
Ensembl chr17:58,816,442...58,821,247

G

barrier to autointegration nuclear assembly factor 1

increases expression

ISO

Antimycin A results in increased expression of BANF1 mRNA

NCBI chr 1:212,101,523...212,103,568
Ensembl chr 1:212,101,523...212,103,552

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

ISO

[FOXO1 protein co-treated with FOXO4 protein co-treated with FOXO3 protein] affects the reaction [Resveratrol inhibits the reaction [Antimycin A results in increased expression of BAX protein]]; Resveratrol inhibits the reaction [Antimycin A results in increased expression of BAX protein]
Acetylcysteine inhibits the reaction [Antimycin A results in increased expression of BAX mRNA]

PMID:24040102 PMID:33512557 PMID:35430258

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

decreases response to substance
multiple interactions

ISO

BCL2 protein results in decreased susceptibility to Antimycin A
PK 11195 inhibits the reaction [BCL2 protein results in decreased susceptibility to Antimycin A]

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

Bcl2-like 13

decreases expression

ISO

Antimycin A results in decreased expression of BCL2L13 mRNA

NCBI chr 4:155,728,284...155,785,058
Ensembl chr 4:155,728,284...155,781,158

G

BAF chromatin remodeling complex subunit BCL7B

decreases expression

ISO

Antimycin A results in decreased expression of BCL7B mRNA

NCBI chr12:27,133,412...27,146,631
Ensembl chr12:27,133,412...27,146,636

G

bone gamma-carboxyglutamate protein

increases expression
multiple interactions

ISO

Antimycin A results in increased expression of BGLAP protein
sciadopitysin inhibits the reaction [Antimycin A results in increased expression of BGLAP protein]

NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:176,136,341...176,137,318

G

BH3 interacting domain death agonist

decreases expression

ISO

Antimycin A results in decreased expression of BID mRNA

NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:155,785,377...155,808,275

G

baculoviral IAP repeat-containing 5

increases expression

ISO

Antimycin A results in increased expression of BIRC5 mRNA

NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155

G

Bcl2 modifying factor

decreases expression

ISO

Antimycin A results in decreased expression of BMF mRNA

NCBI chr 3:125,953,466...125,974,087
Ensembl chr 3:125,953,466...125,974,258

G

BCL2 interacting protein 1

increases expression

ISO

Antimycin A results in increased expression of BNIP1 mRNA

NCBI chr10:16,891,317...16,903,561
Ensembl chr10:16,891,317...16,903,561

G

BCL2 interacting protein 3

increases expression

ISO

Antimycin A results in increased expression of BNIP3 mRNA

NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:203,137,778...203,154,962

G

biphenyl hydrolase like

decreases expression

ISO

Antimycin A results in decreased expression of BPHL mRNA

NCBI chr17:31,006,283...31,042,631
Ensembl chr17:31,004,972...31,042,632

G

bromodomain containing 3

decreases expression

ISO

Antimycin A results in decreased expression of BRD3 mRNA

NCBI chr 3:31,173,332...31,227,749
Ensembl chr 3:31,173,332...31,227,629

G

BSCL2 lipid droplet biogenesis associated, seipin

decreases expression

ISO

Antimycin A results in decreased expression of BSCL2 mRNA

NCBI chr 1:215,160,764...215,172,540
Ensembl chr 1:215,160,957...215,172,536

G

BTG anti-proliferation factor 2

increases expression

ISO

Antimycin A results in increased expression of BTG2 mRNA

NCBI chr13:48,083,931...48,087,690
Ensembl chr13:48,083,931...48,087,690

G

BTG anti-proliferation factor 3

increases expression

ISO

Antimycin A results in increased expression of BTG3 mRNA

NCBI chr11:30,517,068...30,532,981
Ensembl chr11:30,517,072...30,533,082

G

BUB1 mitotic checkpoint serine/threonine kinase

increases expression

ISO

Antimycin A results in increased expression of BUB1 mRNA

NCBI chr 3:135,473,525...135,504,921
Ensembl chr 3:135,472,582...135,504,921

G

basic leucine zipper and W2 domains 2

increases expression

ISO

Antimycin A results in increased expression of BZW2 mRNA

NCBI chr 6:58,555,362...58,615,921
Ensembl chr 6:58,554,961...58,615,912

G

C1D nuclear receptor corepressor

increases expression

ISO

Antimycin A results in increased expression of C1D mRNA

NCBI chr14:95,862,550...95,874,796
Ensembl chr14:95,861,978...95,874,796

G

C2 calcium-dependent domain containing 5

decreases expression

ISO

Antimycin A results in decreased expression of C2CD5 mRNA

NCBI chr 4:177,700,515...177,790,576
Ensembl chr 4:177,700,516...177,786,717

G

carbonic anhydrase 6

increases expression

ISO

Antimycin A results in increased expression of CAR6 mRNA

NCBI chr 5:165,941,028...165,959,566
Ensembl chr 5:165,941,029...165,959,566

G

calmodulin 1

decreases expression

ISO

Antimycin A results in decreased expression of CALM1 mRNA

NCBI chr 6:125,217,191...125,227,855
Ensembl chr 6:125,217,246...125,225,381

G

calcium/calmodulin-dependent protein kinase II beta

decreases expression

ISO

Antimycin A results in decreased expression of CAMK2B mRNA

NCBI chr14:85,059,166...85,148,121
Ensembl chr14:85,059,191...85,148,485

G

calcyphosine

decreases expression

ISO

Antimycin A results in decreased expression of CAPS mRNA

NCBI chr 9:1,630,871...1,632,758

G

cysteinyl-tRNA synthetase 1

increases expression

ISO

Antimycin A results in increased expression of CARS1 mRNA

NCBI chr 1:208,183,092...208,225,425
Ensembl chr 1:208,182,788...208,225,407

G

caspase 1

increases activity

ISO

Antimycin A results in increased activity of CASP1 protein

NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275

G

caspase 3

increases cleavage
increases activity
increases expression
multiple interactions

ISO
EXP

Antimycin A results in increased cleavage of CASP3 protein
Antimycin A results in increased activity of CASP3 protein
Antimycin A results in increased expression of CASP3 mRNA
[chromium hexavalent ion co-treated with Antimycin A] results in increased activity of CASP3 protein; Acetylcysteine inhibits the reaction [Antimycin A results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [Antimycin A results in increased expression of CASP3 mRNA]; Ascorbic Acid inhibits the reaction [[chromium hexavalent ion co-treated with Antimycin A] results in increased activity of CASP3 protein]; Ascorbic Acid inhibits the reaction [Antimycin A results in increased activity of CASP3 protein]
NAD inhibits the reaction [Antimycin A results in increased cleavage of CASP3 protein]; Niacinamide promotes the reaction [Antimycin A results in increased cleavage of CASP3 protein]; Resveratrol inhibits the reaction [Antimycin A results in increased cleavage of CASP3 protein]; splitomicin promotes the reaction [Antimycin A results in increased cleavage of CASP3 protein]

PMID:11078377 PMID:24040102 PMID:24732427 PMID:32662599 PMID:35430258

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 8

multiple interactions
increases cleavage

ISO

Acetylcysteine inhibits the reaction [Antimycin A results in increased cleavage of CASP8 protein]

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

caspase 9

increases cleavage
decreases expression
multiple interactions

ISO

Antimycin A results in increased cleavage of CASP9 protein
Antimycin A results in decreased expression of CASP9 mRNA
Acetylcysteine inhibits the reaction [Antimycin A results in increased cleavage of CASP9 protein]

PMID:32662599 PMID:33512557

Ensembl chr 5:159,391,188...159,409,648

G

calpastatin

decreases expression

ISO

Antimycin A results in decreased expression of CAST mRNA

NCBI chr 2:5,707,633...5,817,213
Ensembl chr 2:5,707,640...5,817,180

G

catalase

increases expression
multiple interactions

ISO

Antimycin A results in increased expression of CAT mRNA
Acetylcysteine inhibits the reaction [Antimycin A results in increased expression of CAT mRNA]

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

carbonyl reductase 1

decreases expression

ISO

Antimycin A results in decreased expression of CBR1 mRNA

NCBI chr11:46,346,405...46,348,815
Ensembl chr11:46,378,411...46,381,104
Ensembl chr11:46,378,411...46,381,104

G

chromobox 4

increases expression

ISO

Antimycin A results in increased expression of CBX4 mRNA

NCBI chr10:104,835,685...104,841,727
Ensembl chr10:104,835,685...104,841,727

G

C-C motif chemokine ligand 2

decreases expression

ISO

Antimycin A results in decreased expression of CCL2 protein

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

C-C motif chemokine ligand 3

decreases expression

ISO

Antimycin A results in decreased expression of CCL3 protein

NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439

G

C-C motif chemokine ligand 4

decreases expression

ISO

Antimycin A results in decreased expression of CCL4 protein

NCBI chr10:68,963,893...68,965,728
Ensembl chr10:68,950,289...68,965,722

G

C-C motif chemokine ligand 5

decreases expression

ISO

Antimycin A results in decreased expression of CCL5 protein

NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884

G

C-C motif chemokine ligand 9

decreases expression

ISO

Antimycin A results in decreased expression of CCL15 mRNA

NCBI chr10:68,863,994...68,868,928
Ensembl chr10:68,863,995...68,868,877

G

cellular communication network factor 1

increases expression

ISO

Antimycin A results in increased expression of CCN1 mRNA

NCBI chr 2:237,222,730...237,225,689
Ensembl chr 2:237,222,432...237,225,883

G

cellular communication network factor 2

increases expression

ISO

Antimycin A results in increased expression of CCN2 mRNA

NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:22,621,501...22,624,976

G

cyclin A2

decreases expression
increases expression
multiple interactions

ISO

Antimycin A results in decreased expression of CCNA2 mRNA; Antimycin A results in decreased expression of CCNA2 protein
Antimycin A results in increased expression of CCNA2 mRNA
Antimycin A inhibits the reaction [ELAVL1 protein binds to CCNA2 3' UTR]

PMID:12730239 PMID:33512557

NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:121,355,363...121,361,701

G

cyclin B1

multiple interactions
increases expression
decreases expression

ISO

Antimycin A inhibits the reaction [ELAVL1 protein binds to CCNB1 3' UTR]
Antimycin A results in increased expression of CCNB1 mRNA
Antimycin A results in decreased expression of CCNB1 mRNA; Antimycin A results in decreased expression of CCNB1 protein

PMID:12730239 PMID:33512557

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225

G

cyclin B2

increases expression

ISO

Antimycin A results in increased expression of CCNB2 mRNA

NCBI chr 8:79,968,459...79,981,717
Ensembl chr 8:79,968,465...79,981,682

G

cyclin D2

increases expression

ISO

Antimycin A results in increased expression of CCND2 mRNA

NCBI chr 4:161,653,048...161,675,422
Ensembl chr 4:161,653,048...161,680,301
Ensembl chr 4:161,653,048...161,680,301

G

cyclin G1

increases expression

ISO

Antimycin A results in increased expression of CCNG1 mRNA

NCBI chr10:25,678,503...25,684,876
Ensembl chr10:25,677,885...25,683,766

G

cyclin H

increases expression

ISO

Antimycin A results in increased expression of CCNH mRNA

NCBI chr 2:17,570,449...17,591,078
Ensembl chr 2:17,570,263...17,614,860

G

CD14 molecule

increases expression

ISO

Antimycin A results in increased expression of CD14 mRNA

NCBI chr18:28,609,558...28,611,409
Ensembl chr18:28,608,883...28,611,292

G

CD24 molecule

decreases expression

ISO

Antimycin A results in decreased expression of CD24 mRNA

NCBI chr20:48,655,549...48,661,786
Ensembl chr20:48,655,805...48,661,785

G

CD34 molecule

decreases expression

ISO

Antimycin A results in decreased expression of CD34 mRNA

NCBI chr13:109,008,786...109,029,317
Ensembl chr13:109,008,623...109,029,315

G

CD38 molecule

increases expression

ISO

Antimycin A results in increased expression of CD38 mRNA

NCBI chr14:71,384,532...71,424,794
Ensembl chr14:71,384,532...71,424,505

G

CD55 molecule (Cromer blood group)

decreases expression

ISO

Antimycin A results in decreased expression of CD55 mRNA

NCBI chr13:44,409,574...44,438,913
Ensembl chr13:44,409,587...44,438,107

G

Cd68 molecule

increases expression

ISO

Antimycin A results in increased expression of CD68 mRNA

NCBI chr10:54,880,562...54,882,441
Ensembl chr10:54,880,563...54,882,540

G

cell division cycle 6

increases expression
decreases expression

ISO

Antimycin A results in increased expression of CDC6 mRNA
Antimycin A results in decreased expression of CDC6 mRNA

PMID:33512557 PMID:34642769

NCBI chr10:84,360,361...84,374,239
Ensembl chr10:84,360,381...84,374,241

G

cell division cycle associated 3

increases expression

ISO

Antimycin A results in increased expression of CDCA3 mRNA

NCBI chr 4:159,321,203...159,325,072
Ensembl chr 4:159,321,014...159,325,068

G

cell division cycle associated 5

increases expression

ISO

Antimycin A results in increased expression of CDCA5 mRNA

NCBI chr 1:212,807,863...212,821,313
Ensembl chr 1:212,804,014...212,821,309

G

cell division cycle associated 8

increases expression

ISO

Antimycin A results in increased expression of CDCA8 mRNA

NCBI chr 5:142,461,082...142,483,336
Ensembl chr 5:142,461,084...142,483,283

G

cadherin 10

decreases expression

ISO

Antimycin A results in decreased expression of CDH10 mRNA

NCBI chr 2:70,355,521...70,577,880
Ensembl chr 2:70,357,217...70,578,332

G

cadherin 2

decreases expression

ISO

Antimycin A results in decreased expression of CDH2 mRNA

NCBI chr18:8,051,097...8,265,288
Ensembl chr18:8,051,097...8,265,288

G

cyclin-dependent kinase 1

increases expression

ISO

Antimycin A results in increased expression of CDK1 mRNA

NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455

G

cyclin-dependent kinase 5

decreases expression

ISO

Antimycin A results in decreased expression of CDK5 mRNA

NCBI chr 4:11,647,098...11,651,606
Ensembl chr 4:11,647,141...11,652,777

G

cyclin-dependent kinase 5 regulatory subunit 1

decreases expression

ISO

Antimycin A results in decreased expression of CDK5R1 mRNA

NCBI chr10:65,981,692...65,985,831
Ensembl chr10:65,978,911...65,989,272

G

cyclin-dependent kinase inhibitor 3

increases expression

ISO

Antimycin A results in increased expression of CDKN3 mRNA

NCBI chr15:22,502,299...22,513,725
Ensembl chr15:22,502,382...22,513,722

G

chromatin licensing and DNA replication factor 1

increases expression

ISO

Antimycin A results in increased expression of CDT1 mRNA

NCBI chr19:67,529,249...67,534,195
Ensembl chr19:67,529,201...67,534,194

G

CCAAT/enhancer binding protein alpha

increases expression

ISO

Antimycin A results in increased expression of CEBPA mRNA

NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:96,896,171...96,899,309

G

CCAAT/enhancer binding protein beta

increases expression

ISO

Antimycin A results in increased expression of CEBPB mRNA

NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:176,816,859...176,838,072

G

carboxyl ester lipase

decreases expression

ISO

Antimycin A results in decreased expression of CEL mRNA

NCBI chr 3:32,281,518...32,289,019
Ensembl chr 3:32,281,518...32,289,019

G

cell migration inducing hyaluronidase 2

decreases expression

ISO

Antimycin A results in decreased expression of CEMIP2 mRNA

NCBI chr 1:228,756,826...228,834,313
Ensembl chr 1:228,757,466...228,832,906

G

centromere protein F

increases expression

ISO

Antimycin A results in increased expression of CENPF mRNA

NCBI chr13:103,715,344...103,760,931
Ensembl chr13:103,715,344...103,760,886

G

centromere protein U

increases expression

ISO

Antimycin A results in increased expression of CENPU mRNA

NCBI chr16:52,448,446...52,471,662
Ensembl chr16:52,425,096...52,471,662

G

centromere protein W

increases expression

ISO

Antimycin A results in increased expression of CENPW mRNA

NCBI chr 1:29,353,939...29,359,109
Ensembl chr 1:29,353,970...29,359,109

G

centrosomal protein 55

increases expression

ISO

Antimycin A results in increased expression of CEP55 mRNA

NCBI chr 1:245,245,272...245,260,835
Ensembl chr 1:245,245,306...245,260,890

G

centrosomal protein 57

decreases expression

ISO

Antimycin A results in decreased expression of CEP57 mRNA

NCBI chr 8:18,951,179...18,971,205
Ensembl chr 8:18,932,808...18,970,890

G

centrin 3

decreases expression

ISO

Antimycin A results in decreased expression of CETN3 mRNA

NCBI chr 2:13,817,760...13,837,502
Ensembl chr 2:13,824,803...13,837,502

G

ChaC glutathione-specific gamma-glutamylcyclotransferase 1

increases expression

ISO

Antimycin A results in increased expression of CHAC1 mRNA

NCBI chr 3:126,796,131...126,799,352
Ensembl chr 3:126,796,024...126,799,361

G

coiled-coil-helix-coiled-coil-helix domain containing 10

increases expression

ISO

Antimycin A results in increased expression of CHCHD10 mRNA

NCBI chr20:12,725,274...12,730,295
Ensembl chr20:12,725,277...12,745,677

G

checkpoint kinase 1

increases expression

ISO

Antimycin A results in increased expression of CHEK1 mRNA

NCBI chr 8:44,609,417...44,629,867
Ensembl chr 8:44,609,417...44,629,359

G

charged multivesicular body protein 6

decreases expression

ISO

Antimycin A results in decreased expression of CHMP6 mRNA

NCBI chr10:105,690,400...105,696,070
Ensembl chr10:105,690,398...105,696,333

G

cholinergic receptor nicotinic beta 2 subunit

decreases expression

ISO

Antimycin A results in decreased expression of CHRNB2 mRNA

NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:177,479,091...177,491,326

G

cytosolic iron-sulfur assembly component 2A

decreases expression

ISO

Antimycin A results in decreased expression of CIAO2A mRNA

NCBI chr 8:75,565,620...75,577,542
Ensembl chr 8:75,565,567...75,577,541

G

CDC28 protein kinase regulatory subunit 1B

increases expression

ISO

Antimycin A results in increased expression of CKS1B mRNA

NCBI chr 2:177,130,751...177,135,333
Ensembl chr 2:177,130,777...177,135,365

G

CDC28 protein kinase regulatory subunit 2

increases expression

ISO

Antimycin A results in increased expression of CKS2 mRNA

NCBI chr17:13,722,360...13,727,519
Ensembl chr17:13,722,361...13,727,519

G

chloride intracellular channel 4

increases expression

ISO

Antimycin A results in increased expression of CLIC4 mRNA

NCBI chr 5:152,737,371...152,797,118
Ensembl chr 5:152,737,371...152,797,118

G

calponin 3

increases expression

ISO

Antimycin A results in increased expression of CNN3 mRNA

NCBI chr 2:212,203,661...212,234,772
Ensembl chr 2:212,226,640...212,234,815

G

contactin 1

increases expression

ISO

Antimycin A results in increased expression of CNTN1 mRNA

NCBI chr 7:125,142,638...125,440,397
Ensembl chr 7:125,142,696...125,440,391

G

cytochrome c oxidase assembly factor 6

increases expression

ISO

Antimycin A results in increased expression of COA6 mRNA

NCBI chr19:71,293,066...71,295,668
Ensembl chr19:71,278,765...71,296,015

G

component of oligomeric golgi complex 2

decreases expression

ISO

Antimycin A results in decreased expression of COG2 mRNA

NCBI chr19:69,391,305...69,430,072
Ensembl chr19:69,391,326...69,426,620

G

collagen type XVI alpha 1 chain

decreases expression
increases expression

ISO

Antimycin A results in decreased expression of COL16A1 mRNA
Antimycin A results in increased expression of COL16A1 mRNA

PMID:19304788 PMID:33512557

NCBI chr 5:147,672,559...147,727,007
Ensembl chr 5:147,672,601...147,727,011

G

collagen type I alpha 1 chain

increases expression

ISO

Antimycin A results in increased expression of COL1A1 mRNA

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460

G

collagen type IV alpha 1 chain

increases expression

ISO

Antimycin A results in increased expression of COL4A1 mRNA

NCBI chr16:84,885,597...84,996,482
Ensembl chr16:84,885,597...84,996,482

G

collagen type IV alpha 2 chain

increases expression

ISO

Antimycin A results in increased expression of COL4A2 mRNA

NCBI chr16:84,749,672...84,885,520
Ensembl chr16:84,749,672...84,885,520

G

COP9 signalosome subunit 5

decreases expression

ISO

Antimycin A results in decreased expression of COPS5 mRNA

NCBI chr 5:13,975,198...13,993,391
Ensembl chr 5:13,975,052...13,993,387

G

cytochrome c oxidase subunit 6A2

increases expression

ISO

Antimycin A results in increased expression of COX6A2 mRNA

NCBI chr 1:192,218,970...192,221,188
Ensembl chr 1:192,218,970...192,219,716

G

ceruloplasmin

increases degradation
decreases expression

ISO

Antimycin A results in increased degradation of CP mRNA
Antimycin A results in decreased expression of CP mRNA; Antimycin A results in decreased expression of CP protein

NCBI chr 2:104,368,336...104,427,119
Ensembl chr 2:104,368,456...104,427,087

G

copine 3

decreases expression

ISO

Antimycin A results in decreased expression of CPNE3 mRNA

NCBI chr 5:37,811,566...37,860,840
Ensembl chr 5:37,811,566...37,861,062

G

cramped chromatin regulator homolog 1

decreases expression

ISO

Antimycin A results in decreased expression of CRAMP1 mRNA

NCBI chr10:14,488,292...14,536,844
Ensembl chr10:14,467,661...14,535,664

G

cAMP responsive element binding protein 1

multiple interactions
decreases phosphorylation

ISO

23-epi-26-deoxyactein inhibits the reaction [Antimycin A results in decreased phosphorylation of CREB1 protein]; acetovanillone inhibits the reaction [Antimycin A results in decreased phosphorylation of CREB1 protein]

PMID:21538410 PMID:22180388

NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339

G

CREB3 regulatory factor

increases expression

ISO

Antimycin A results in increased expression of CREBRF mRNA

NCBI chr10:16,903,607...16,967,450
Ensembl chr10:16,903,547...16,966,430

G

cellular repressor of E1A-stimulated genes 1

increases expression

ISO

Antimycin A results in increased expression of CREG1 mRNA

NCBI chr13:80,552,779...80,565,272
Ensembl chr13:80,549,933...80,565,272

G

CRK proto-oncogene, adaptor protein

decreases expression

ISO

Antimycin A results in decreased expression of CRK mRNA

NCBI chr10:61,028,736...61,054,971
Ensembl chr10:61,028,757...61,082,988

G

casein kinase 1, delta

decreases expression

ISO

Antimycin A results in decreased expression of CSNK1D mRNA

NCBI chr10:106,713,497...106,754,953
Ensembl chr10:106,694,279...106,754,953

G

cysteine and serine rich nuclear protein 1

increases expression

ISO

Antimycin A results in increased expression of CSRNP1 mRNA

NCBI chr 8:128,582,364...128,594,163
Ensembl chr 8:128,582,365...128,588,469

G

cystathionine gamma-lyase

increases expression

ISO

Antimycin A results in increased expression of CTH mRNA

NCBI chr 2:249,634,731...249,661,066
Ensembl chr 2:249,634,731...249,661,066

G

catenin alpha-like 1

increases expression

ISO

Antimycin A results in increased expression of CTNNAL1 mRNA

NCBI chr 5:76,309,546...76,375,869
Ensembl chr 5:76,309,546...76,364,637

G

CTP synthase 1

decreases expression

ISO

Antimycin A results in decreased expression of CTPS1 mRNA

NCBI chr 5:139,372,349...139,440,441
Ensembl chr 5:139,410,249...139,440,465

G

cathepsin L

increases expression

ISO

Antimycin A results in increased expression of CTSL mRNA

NCBI chr17:770,104...776,266
Ensembl chr17:770,093...777,113

G

cortactin

decreases expression

ISO

Antimycin A results in decreased expression of CTTN mRNA

NCBI chr 1:209,029,048...209,064,577
Ensembl chr 1:209,029,048...209,058,211

G

C-X-C motif chemokine ligand 3

multiple interactions

ISO

Antimycin A inhibits the reaction [TNF protein results in increased expression of CXCL1 mRNA]

NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624

G

C-X-C motif chemokine receptor 4

decreases expression

ISO

Antimycin A results in decreased expression of CXCR4 mRNA

NCBI chr13:42,630,383...42,634,288
Ensembl chr13:42,630,104...42,634,459

G

cytochrome c, somatic

multiple interactions
affects localization

ISO

glabridin inhibits the reaction [Antimycin A affects the localization of CYCS protein]

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816

G

cytochrome P450, family 3, subfamily a, polypeptide 9

increases expression

ISO

Antimycin A results in increased expression of CYP3A5 mRNA

NCBI chr12:21,919,955...21,960,160
Ensembl chr12:21,919,940...21,960,154

G

dishevelled associated activator of morphogenesis 1

decreases expression

ISO

Antimycin A results in decreased expression of DAAM1 mRNA

NCBI chr 6:96,125,521...96,286,049
Ensembl chr 6:96,125,621...96,286,049

G

dystroglycan 1

decreases expression

ISO

Antimycin A results in decreased expression of DAG1 mRNA

NCBI chr 8:117,769,517...117,834,347
Ensembl chr 8:117,769,517...117,782,199

G

death-domain associated protein

decreases expression

ISO

Antimycin A results in decreased expression of DAXX mRNA

NCBI chr20:4,971,973...4,978,062
Ensembl chr20:4,971,941...4,977,720

G

dCMP deaminase

decreases expression

ISO

Antimycin A results in decreased expression of DCTD mRNA

NCBI chr16:50,799,699...50,831,398
Ensembl chr16:50,787,875...50,831,186

G

doublecortin

decreases expression

ISO

Antimycin A results in decreased expression of DCX mRNA

NCBI chr X:112,227,455...112,370,291
Ensembl chr X:112,227,455...112,304,161

G

dopa decarboxylase

decreases expression

ISO

Antimycin A results in decreased expression of DDC mRNA

NCBI chr14:90,592,304...90,682,830
Ensembl chr14:90,592,304...90,682,806

G

DNA-damage inducible transcript 3

increases expression

EXP
ISO

Antimycin A results in increased expression of DDIT3 protein
Antimycin A results in increased expression of DDIT3 mRNA

PMID:19304788 PMID:21337367 PMID:33512557

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

DNA-damage-inducible transcript 4

increases expression

ISO

Antimycin A results in increased expression of DDIT4 mRNA

NCBI chr20:28,434,938...28,437,037
Ensembl chr20:28,434,944...28,437,037

G

DEXD/H-box helicase 60

decreases expression

ISO

Antimycin A results in decreased expression of DDX60 mRNA

NCBI chr16:33,087,940...33,208,843
Ensembl chr16:33,087,988...33,208,839

G

DEK proto-oncogene

increases expression

ISO

Antimycin A results in increased expression of DEK mRNA

NCBI chr17:17,786,989...17,809,096
Ensembl chr17:17,787,139...17,810,122

G

DEP domain containing 1B

increases expression

ISO

Antimycin A results in increased expression of DEPDC1B mRNA

NCBI chr 2:41,605,686...41,697,207
Ensembl chr 2:41,624,922...41,697,202

G

DNA fragmentation factor subunit beta

decreases expression

ISO

Antimycin A results in decreased expression of DFFB mRNA

NCBI chr 5:169,804,873...169,817,157
Ensembl chr 5:169,804,889...169,817,225

G

DLG associated protein 5

increases expression

ISO

Antimycin A results in increased expression of DLGAP5 mRNA

NCBI chr15:23,113,678...23,144,281
Ensembl chr15:23,113,678...23,144,176

G

delta like canonical Notch ligand 1

increases expression

ISO

Antimycin A results in increased expression of DLL1 mRNA

NCBI chr 1:64,985,161...64,993,274
Ensembl chr 1:64,985,161...64,993,276

G

DnaJ heat shock protein family (Hsp40) member B6

increases expression

ISO

Antimycin A results in increased expression of DNAJB6 mRNA

NCBI chr 4:6,010,081...6,232,052
Ensembl chr 4:6,128,070...6,232,005

G

dopamine receptor D2

decreases expression

ISO

Antimycin A results in decreased expression of DRD2 mRNA

NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:58,605,403...58,669,339

G

dual specificity phosphatase 1

increases expression

ISO

Antimycin A results in increased expression of DUSP1 mRNA

NCBI chr10:17,184,853...17,187,646
Ensembl chr10:17,184,823...17,187,644

G

dual specificity phosphatase 14

increases expression

ISO

Antimycin A results in increased expression of DUSP14 mRNA

NCBI chr10:69,433,949...69,463,863
Ensembl chr10:69,426,730...69,462,837

G

dual specificity phosphatase 4

increases expression

ISO

Antimycin A results in increased expression of DUSP4 mRNA

NCBI chr16:64,079,893...64,101,396
Ensembl chr16:64,079,893...64,093,700

G

dynein light chain Tctex-type 3

decreases expression

ISO

Antimycin A results in decreased expression of DYNLT3 mRNA

NCBI chr X:16,000,425...16,009,632
Ensembl chr X:16,000,395...16,009,627

G

E2F transcription factor 7

decreases expression

ISO

Antimycin A results in decreased expression of E2F7 mRNA

NCBI chr 7:48,036,881...48,079,055
Ensembl chr 7:48,037,749...48,079,055

G

ELL associated factor 2

decreases expression

ISO

Antimycin A results in decreased expression of EAF2 mRNA

NCBI chr11:77,465,585...77,509,993
Ensembl chr11:77,406,020...77,509,993

G

EBNA1 binding protein 2

decreases expression

ISO

Antimycin A results in decreased expression of EBNA1BP2 mRNA

NCBI chr 5:137,433,534...137,438,100
Ensembl chr 5:137,433,226...137,438,637

G

enoyl-CoA delta isomerase 1

decreases expression

ISO

Antimycin A results in decreased expression of ECI1 mRNA

NCBI chr10:13,961,250...13,974,595
Ensembl chr10:13,961,218...13,974,773

G

early growth response 1

increases expression

ISO

Antimycin A results in increased expression of EGR1 mRNA

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843

G

eukaryotic translation initiation factor 1A, X-linked

increases expression

ISO

Antimycin A results in increased expression of EIF1AX mRNA

NCBI chr X:39,307,320...39,322,023
Ensembl chr X:39,307,137...39,322,021

G

eukaryotic translation initiation factor 3 subunit E

decreases expression

ISO

Antimycin A results in decreased expression of EIF3E mRNA

NCBI chr 7:76,224,567...76,257,346
Ensembl chr 7:76,224,568...76,257,785

G

eukaryotic translation initiation factor 4E binding protein 1

increases expression

ISO

Antimycin A results in increased expression of EIF4EBP1 mRNA

NCBI chr16:71,495,457...71,508,845
Ensembl chr16:71,487,930...71,508,874

G

eukaryotic translation initiation factor 6

increases expression

ISO

Antimycin A results in increased expression of EIF6 mRNA

NCBI chr 3:164,785,162...164,791,410
Ensembl chr 3:164,785,163...164,791,525

G

ELAV like RNA binding protein 1

multiple interactions
decreases expression
decreases localization

ISO

Antimycin A inhibits the reaction [ELAVL1 protein binds to CCNA2 3' UTR]; Antimycin A inhibits the reaction [ELAVL1 protein binds to CCNB1 3' UTR]
Antimycin A results in decreased expression of ELAVL1 mRNA
Antimycin A results in decreased localization of ELAVL1 protein

PMID:12730239 PMID:33512557

NCBI chr12:7,441,699...7,482,625
Ensembl chr12:7,441,699...7,482,631

G

ELAV like RNA binding protein 3

decreases expression

ISO

Antimycin A results in decreased expression of ELAVL3 mRNA

NCBI chr 8:28,823,120...28,859,395
Ensembl chr 8:28,825,707...28,859,659

G

ELMO domain containing 1

decreases expression

ISO

Antimycin A results in decreased expression of ELMOD1 mRNA

NCBI chr 8:63,194,539...63,251,526
Ensembl chr 8:63,137,295...63,251,322

G

EMG1 N1-specific pseudouridine methyltransferase

increases expression

ISO

Antimycin A results in increased expression of EMG1 mRNA

NCBI chr 4:159,195,545...159,203,826
Ensembl chr 4:159,195,564...159,203,826

G

ectonucleoside triphosphate diphosphohydrolase 2

increases expression

ISO

Antimycin A results in increased expression of ENTPD2 mRNA

NCBI chr 3:28,611,722...28,617,237
Ensembl chr 3:28,611,772...28,618,184

G

E1A binding protein p300

decreases expression

ISO

Antimycin A results in decreased expression of EP300 mRNA

NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:114,946,982...115,058,574

G

endothelial PAS domain protein 1

multiple interactions

EXP

Antimycin A inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]

NCBI chr 6:13,543,252...13,626,147
Ensembl chr 6:13,544,389...13,624,729

G

Eph receptor A3

decreases expression

ISO

Antimycin A results in decreased expression of EPHA3 mRNA

NCBI chr11:14,585,041...14,920,721
Ensembl chr11:14,586,727...14,920,425

G

Eph receptor B2

decreases expression

ISO

Antimycin A results in decreased expression of EPHB2 mRNA

NCBI chr 5:154,179,065...154,360,459
Ensembl chr 5:154,179,065...154,360,615

G

erb-b2 receptor tyrosine kinase 3

increases expression

ISO

Antimycin A results in increased expression of ERBB3 mRNA

NCBI chr 7:1,579,079...1,600,379
Ensembl chr 7:1,579,816...1,601,120

G

endoplasmic reticulum oxidoreductase 1 alpha

increases expression

ISO

Antimycin A results in increased expression of ERO1A mRNA

NCBI chr15:20,974,771...21,010,170
Ensembl chr15:20,972,679...21,018,039

G

ETS proto-oncogene 1, transcription factor

increases expression

ISO

Antimycin A results in increased expression of ETS1 mRNA

NCBI chr 8:39,303,936...39,426,022
Ensembl chr 8:39,303,925...39,426,021

G

ETS variant transcription factor 1

decreases expression

ISO

Antimycin A results in decreased expression of ETV1 mRNA

NCBI chr 6:61,316,836...61,408,985
Ensembl chr 6:61,317,429...61,408,959

G

Enah/Vasp-like

decreases expression

ISO

Antimycin A results in decreased expression of EVL mRNA

NCBI chr 6:133,238,547...133,358,730
Ensembl chr 6:133,238,547...133,358,729

G

exosome component 8

increases expression

ISO

Antimycin A results in increased expression of EXOSC8 mRNA

NCBI chr 2:141,080,568...141,087,112
Ensembl chr 2:141,080,568...141,087,229

G

family with sequence similarity 174, member A

decreases expression

ISO

Antimycin A results in decreased expression of FAM174A mRNA

NCBI chr 9:103,190,144...103,208,419
Ensembl chr 9:103,190,127...103,209,228

G

family with sequence similarity 217, member B

increases expression

ISO

Antimycin A results in increased expression of FAM217B mRNA

NCBI chr 3:185,883,277...185,892,976
Ensembl chr 3:185,883,367...185,892,974

G

family with sequence similarity 72, member A

increases expression

ISO

Antimycin A results in increased expression of FAM72A mRNA

NCBI chr13:45,519,940...45,531,322
Ensembl chr13:45,519,818...45,531,324

G

family with sequence similarity 83, member D

increases expression

ISO

Antimycin A results in increased expression of FAM83D mRNA

NCBI chr 3:167,841,748...167,861,062
Ensembl chr 3:167,841,791...167,861,061

G

Fas cell surface death receptor

decreases expression
increases expression

ISO

Antimycin A results in decreased expression of FAS mRNA
Antimycin A results in increased expression of FAS mRNA

PMID:8902626 PMID:33512557

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104

G

fatty acid synthase

decreases expression

ISO

Antimycin A results in decreased expression of FASN mRNA

NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583

G

fasciculation and elongation protein zeta 2

decreases expression

ISO

Antimycin A results in decreased expression of FEZ2 mRNA

NCBI chr 6:22,406,685...22,446,745
Ensembl chr 6:22,406,632...22,447,041

G

fibroblast growth factor 1

decreases expression

ISO

Antimycin A results in decreased expression of FGF1 mRNA

NCBI chr18:30,937,670...31,023,786
Ensembl chr18:30,939,870...30,961,393

G

fibroblast growth factor 2

increases expression

ISO

Antimycin A results in increased expression of FGF2 mRNA

NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:122,164,454...122,224,493

G

FIG4 phosphoinositide 5-phosphatase

decreases expression

ISO

Antimycin A results in decreased expression of FIG4 mRNA

NCBI chr20:46,183,225...46,306,686
Ensembl chr20:46,183,225...46,306,477

G

FKBP prolyl isomerase 4

increases expression

ISO

Antimycin A results in increased expression of FKBP4 mRNA

NCBI chr 4:163,389,464...163,397,918
Ensembl chr 4:163,389,464...163,397,918

G

FKBP prolyl isomerase 5

increases expression

ISO

Antimycin A results in increased expression of FKBP5 mRNA

NCBI chr20:6,458,931...6,577,227
Ensembl chr20:6,458,940...6,543,118

G

filamin A

increases expression

ISO

Antimycin A results in increased expression of FLNA mRNA

NCBI chr X:157,159,051...157,185,559
Ensembl chr X:157,159,051...157,182,343

G

fibronectin leucine rich transmembrane protein 3

increases expression

ISO

Antimycin A results in increased expression of FLRT3 mRNA

NCBI chr 3:148,448,115...148,461,458
Ensembl chr 3:148,439,354...148,461,650

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

ISO

Antimycin A results in increased expression of FOS mRNA

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

FosB proto-oncogene, AP-1 transcription factor subunit

increases expression

ISO

Antimycin A results in increased expression of FOSB mRNA

NCBI chr 1:88,082,324...88,089,506
Ensembl chr 1:88,082,127...88,089,477

G

FOS like 1, AP-1 transcription factor subunit

increases expression

ISO

Antimycin A results in increased expression of FOSL1 mRNA

NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:212,183,833...212,192,391

G

forkhead box O1

multiple interactions
decreases expression

ISO

[Antimycin A co-treated with Resveratrol] results in decreased acetylation of FOXO1 protein; [FOXO1 protein co-treated with FOXO4 protein co-treated with FOXO3 protein] affects the reaction [Resveratrol inhibits the reaction [Antimycin A results in increased expression of BAX protein]]; FOXO1 mutant form affects the reaction [[Antimycin A co-treated with Resveratrol] affects the expression of SOD2 mRNA]; FOXO1 mutant form affects the reaction [[Antimycin A co-treated with Resveratrol] affects the expression of SOD2 protein]
Antimycin A results in decreased expression of FOXO1 protein

NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:138,462,697...138,541,419

G

forkhead box O3

decreases expression
multiple interactions

ISO

Antimycin A results in decreased expression of FOXO3 protein
[FOXO1 protein co-treated with FOXO4 protein co-treated with FOXO3 protein] affects the reaction [Resveratrol inhibits the reaction [Antimycin A results in increased expression of BAX protein]]; FOXO3 mutant form affects the reaction [[Antimycin A co-treated with Resveratrol] affects the expression of SOD2 mRNA]; FOXO3 mutant form affects the reaction [[Antimycin A co-treated with Resveratrol] affects the expression of SOD2 protein]

NCBI chr20:47,251,968...47,348,254
Ensembl chr20:47,255,878...47,346,845

G

forkhead box O4

multiple interactions
decreases expression

ISO

[FOXO1 protein co-treated with FOXO4 protein co-treated with FOXO3 protein] affects the reaction [Resveratrol inhibits the reaction [Antimycin A results in increased expression of BAX protein]]; FOXO4 mutant form affects the reaction [[Antimycin A co-treated with Resveratrol] affects the expression of SOD2 mRNA]; FOXO4 mutant form affects the reaction [[Antimycin A co-treated with Resveratrol] affects the expression of SOD2 protein]
Antimycin A results in decreased expression of FOXO4 protein

NCBI chr X:70,425,218...70,432,120
Ensembl chr X:70,425,563...70,432,120

G

folylpolyglutamate synthase

decreases expression

ISO

Antimycin A results in decreased expression of FPGS mRNA

NCBI chr 3:36,370,505...36,391,314
Ensembl chr 3:36,370,300...36,391,068

G

ferritin heavy chain 1

increases expression

ISO

Antimycin A results in increased expression of FTH1 mRNA

NCBI chr 1:216,052,037...216,054,325
Ensembl chr 1:216,051,998...216,055,214

G

ferritin light chain 1

increases expression

ISO

Antimycin A results in increased expression of FTL mRNA

NCBI chr 1:105,072,858...105,074,705
Ensembl chr X:45,399,355...45,399,915
Ensembl chr 2:45,399,355...45,399,915
Ensembl chr 1:45,399,355...45,399,915

G

fucosyltransferase 1

increases expression

ISO

Antimycin A results in increased expression of FUT1 mRNA

NCBI chr 1:105,223,399...105,226,817
Ensembl chr 1:105,223,390...105,227,513

G

FYN proto-oncogene, Src family tyrosine kinase

decreases expression

ISO

Antimycin A results in decreased expression of FYN mRNA

NCBI chr20:44,322,635...44,514,498
Ensembl chr20:44,322,361...44,515,479

G

frizzled class receptor 1

decreases expression

ISO

Antimycin A results in decreased expression of FZD1 mRNA

NCBI chr 4:30,265,074...30,269,472
Ensembl chr 4:30,247,228...30,833,176

G

frizzled class receptor 2

decreases expression

ISO

Antimycin A results in decreased expression of FZD2 mRNA

NCBI chr10:88,061,988...88,063,898
Ensembl chr10:88,061,667...88,065,396

G

glucose-6-phosphate dehydrogenase

decreases expression

ISO

Antimycin A results in decreased expression of G6PD mRNA

NCBI chr X:157,352,364...157,372,144
Ensembl chr X:157,352,373...157,372,144

G

GA binding protein transcription factor subunit beta 1

increases expression

ISO

Antimycin A results in increased expression of GABPB1 mRNA

NCBI chr 3:134,333,339...134,380,239
Ensembl chr 3:134,333,339...134,361,344

G

growth arrest and DNA-damage-inducible, alpha

increases expression

ISO

Antimycin A results in increased expression of GADD45A mRNA

PMID:19304788 PMID:33512557

NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:97,484,502...97,486,807

G

growth arrest and DNA-damage-inducible, beta

increases expression

ISO

Antimycin A results in increased expression of GADD45B mRNA

NCBI chr 7:9,428,689...9,430,991
Ensembl chr 7:9,428,689...9,430,718

G

polypeptide N-acetylgalactosaminyltransferase 3

decreases expression

ISO

Antimycin A results in decreased expression of GALNT3 mRNA

NCBI chr 3:71,150,559...71,187,321
Ensembl chr 3:71,150,571...71,174,323

G

growth associated protein 43

decreases expression

ISO

Antimycin A results in decreased expression of GAP43 mRNA

NCBI chr11:71,882,131...71,975,799
Ensembl chr11:71,882,131...71,975,797

G

GATA binding protein 2

increases expression

ISO

Antimycin A results in increased expression of GATA2 mRNA

NCBI chr 4:122,211,501...122,225,058
Ensembl chr 4:122,211,829...122,225,055

G

GTP cyclohydrolase 1

increases expression

ISO

Antimycin A results in increased expression of GCH1 mRNA

NCBI chr15:22,884,006...22,917,412
Ensembl chr15:22,884,006...22,917,412

G

glutamate cysteine ligase, modifier subunit

increases expression

ISO

Antimycin A results in increased expression of GCLM mRNA

NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003

G

growth differentiation factor 15

increases expression

ISO

Antimycin A results in increased expression of GDF15 mRNA

NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,838,436...18,842,022

G

gem (nuclear organelle) associated protein 5

decreases expression

ISO

Antimycin A results in decreased expression of GEMIN5 mRNA

NCBI chr10:42,797,975...42,843,356
Ensembl chr10:42,797,982...42,843,356

G

Gfo/Idh/MocA-like oxidoreductase domain containing 1

increases expression

ISO

Antimycin A results in increased expression of GFOD1 mRNA

NCBI chr17:21,606,090...21,710,922
Ensembl chr17:21,605,415...21,710,920

G

GINS complex subunit 2

increases expression

ISO

Antimycin A results in increased expression of GINS2 mRNA

NCBI chr19:65,535,492...65,548,270
Ensembl chr19:65,535,492...65,548,052

G

gap junction protein, alpha 1

increases expression

ISO

Antimycin A results in increased expression of GJA1 mRNA

NCBI chr20:36,302,490...36,315,010
Ensembl chr20:36,302,352...36,319,689

G

glycine decarboxylase

decreases expression

ISO

Antimycin A results in decreased expression of GLDC mRNA

NCBI chr 1:237,296,753...237,375,620
Ensembl chr 1:237,296,753...237,375,604

G

GLI family zinc finger 3

decreases expression

ISO

Antimycin A results in decreased expression of GLI3 mRNA

NCBI chr17:54,134,064...54,405,198
Ensembl chr17:54,134,064...54,405,198

G

geminin, DNA replication inhibitor

increases expression

ISO

Antimycin A results in increased expression of GMNN mRNA

NCBI chr17:40,729,760...40,738,077
Ensembl chr17:40,729,824...40,738,068

G

G protein subunit alpha i2

decreases expression

ISO

Antimycin A results in decreased expression of GNAI2 mRNA

NCBI chr 8:117,167,045...117,187,652
Ensembl chr 8:117,167,045...117,187,622

G

glucosamine-6-phosphate deaminase 1

decreases expression

ISO

Antimycin A results in decreased expression of GNPDA1 mRNA

NCBI chr18:30,416,599...30,428,630
Ensembl chr18:30,416,607...30,428,630

G

glypican 1

decreases expression

ISO

Antimycin A results in decreased expression of GPC1 mRNA

NCBI chr 9:100,843,645...100,871,458
Ensembl chr 9:100,843,645...100,879,933

G

growth factor receptor bound protein 10

increases expression

ISO

Antimycin A results in increased expression of GRB10 mRNA

NCBI chr14:90,708,653...90,816,399
Ensembl chr14:90,708,653...90,816,387

G

glutamate ionotropic receptor AMPA type subunit 2

decreases expression

ISO

Antimycin A results in decreased expression of GRIA2 mRNA

NCBI chr 2:168,247,490...168,367,616
Ensembl chr 2:168,247,496...168,367,616

G

glutamate metabotropic receptor 4

decreases expression

ISO

Antimycin A results in decreased expression of GRM4 mRNA

NCBI chr20:5,486,024...5,574,668
Ensembl chr20:5,482,977...5,574,668

G

glutathione S-transferase alpha 2

increases expression

ISO

Antimycin A results in increased expression of GSTA2 mRNA

NCBI chr 8:88,064,829...88,077,168
Ensembl chr 8:88,064,616...88,077,092

G

glutathione S-transferase alpha 5

increases expression

ISO

Antimycin A results in increased expression of GSTA1 mRNA

NCBI chr 8:87,985,768...87,997,766
Ensembl chr 8:87,985,258...87,997,765

G

glutathione S-transferase mu 2

decreases expression

ISO

Antimycin A results in decreased expression of GSTM2 mRNA

NCBI chr 2:198,312,179...198,316,962

G

H1.2 linker histone, cluster member

increases expression

ISO

Antimycin A results in increased expression of H1-2 mRNA

NCBI chr17:41,818,962...41,820,453
Ensembl chr17:41,779,051...41,822,317

G

H2B clustered histone 3

increases expression

ISO

Antimycin A results in increased expression of H2BC3 mRNA

NCBI chr17:41,807,913...41,808,543

G

hemoglobin alpha, adult chain 3

increases expression

ISO

Antimycin A results in increased expression of HBA2 mRNA

NCBI chr10:15,816,099...15,816,943
Ensembl chr10:15,816,096...15,817,167

G

histone deacetylase 2

decreases expression

ISO

Antimycin A results in decreased expression of HDAC2 mRNA

NCBI chr20:42,101,815...42,126,486
Ensembl chr20:42,102,861...42,126,311

G

homocysteine inducible ER protein with ubiquitin like domain 1

increases expression

ISO

Antimycin A results in increased expression of HERPUD1 mRNA

NCBI chr19:10,604,360...10,624,168
Ensembl chr19:10,604,362...10,624,081

G

hes family bHLH transcription factor 1

increases expression

ISO

Antimycin A results in increased expression of HES1 mRNA

NCBI chr11:84,210,632...84,213,045
Ensembl chr11:84,210,633...84,213,061

G

hes family bHLH transcription factor 5

increases expression

ISO

Antimycin A results in increased expression of HES5 mRNA

NCBI chr 5:170,804,511...170,807,988
Ensembl chr 5:170,803,940...170,806,021

G

hypoxia inducible factor 1 subunit alpha

affects expression
multiple interactions
increases expression

EXP
ISO

Antimycin A affects the expression of HIF1A protein
Acetylcysteine inhibits the reaction [Antimycin A results in increased expression of HIF1A mRNA]

PMID:16034640 PMID:35430258

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323

G

histone cluster 1 H2A family member H

increases expression

ISO

Antimycin A results in increased expression of H2AC11 mRNA

NCBI chr17:41,812,378...41,812,875
Ensembl chr17:41,797,862...41,812,946

G

histone cluster 1 H2A family like 1

increases expression

ISO

Antimycin A results in increased expression of H2AC6 mRNA

NCBI chr17:47,403,701...47,404,167

G

histone cluster 1 H2B family member D

increases expression

ISO

Antimycin A results in increased expression of H2BC5 mRNA

NCBI chr17:47,488,627...47,489,008

G

high mobility group AT-hook 2

increases expression

ISO

Antimycin A results in increased expression of HMGA2 mRNA

NCBI chr 7:57,762,710...57,884,555
Ensembl chr 7:57,765,675...57,880,341

G

hyaluronan-mediated motility receptor

increases expression

ISO

Antimycin A results in increased expression of HMMR mRNA

NCBI chr10:25,635,249...25,665,389
Ensembl chr10:25,635,915...25,665,390

G

heme oxygenase 1

increases expression

ISO

Antimycin A results in increased expression of HMOX1 mRNA

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

heat shock protein 90 alpha family class A member 1

increases expression

ISO

Antimycin A results in increased expression of HSP90AA1 mRNA

NCBI chr 6:135,523,604...135,529,687
Ensembl chr 6:135,523,616...135,528,499

G

heat shock protein 90 alpha family class B member 1

increases expression

ISO

Antimycin A results in increased expression of HSP90AB1 mRNA

NCBI chr 9:22,930,249...22,935,929
Ensembl chr 9:22,931,070...22,935,926

G

heat shock protein family A (Hsp70) member 1A

increases expression

ISO

Antimycin A results in increased expression of HSPA1A mRNA

NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,855,780...3,877,979

G

heat shock protein family A (Hsp70) member 1B

increases expression

ISO

Antimycin A results in increased expression of HSPA1B mRNA

NCBI chr20:3,859,756...3,863,800
Ensembl chr20:3,855,780...3,877,979

G

heat shock protein family A (Hsp70) member 2

increases expression

ISO

Antimycin A results in increased expression of HSPA2 mRNA

NCBI chr 6:100,864,172...100,866,946
Ensembl chr 6:100,864,553...100,867,133

G

heat shock protein family A (Hsp70) member 5

increases expression

EXP
ISO

Antimycin A results in increased expression of HSPA5 protein
Antimycin A results in increased expression of HSPA5 mRNA

PMID:21337367 PMID:33512557

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790

G

heat shock protein family A (Hsp70) member 6 like, pseudogene 1

increases expression

ISO

Antimycin A results in increased expression of HSPA6 mRNA

NCBI chr13:85,805,911...85,807,052

G

heat shock protein family B (small) member 1

increases expression

ISO

Antimycin A results in increased expression of HSPB1 mRNA

NCBI chr12:26,430,640...26,432,301
Ensembl chr12:26,430,640...26,432,301

G

heat shock protein family B (small) member 8

increases expression

ISO

Antimycin A results in increased expression of HSPB8 mRNA

NCBI chr12:45,835,899...45,866,449
Ensembl chr12:45,837,066...45,851,937

G

heat shock protein family D (Hsp60) member 1

increases expression

ISO

Antimycin A results in increased expression of HSPD1 mRNA

NCBI chr 9:64,073,610...64,084,332
Ensembl chr 9:64,073,611...64,084,037

G

heat shock protein family E (Hsp10) member 1

increases expression

ISO

Antimycin A results in increased expression of HSPE1 mRNA

NCBI chr 9:64,084,327...64,087,415
Ensembl chr 9:64,085,068...64,087,502

G

HtrA serine peptidase 1

increases expression

ISO

Antimycin A results in increased expression of HTRA1 mRNA

NCBI chr 1:194,928,069...194,977,619
Ensembl chr 1:194,927,687...194,977,620

G

intercellular adhesion molecule 1

decreases expression
multiple interactions

ISO

Antimycin A results in decreased expression of ICAM1 mRNA
Antimycin A inhibits the reaction [N-caproylsphingosine results in increased expression of ICAM1 mRNA]

PMID:12952965 PMID:19304788

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617

G

inhibitor of DNA binding 2

increases expression

ISO

Antimycin A results in increased expression of ID2 mRNA

NCBI chr 6:47,469,162...47,470,995
Ensembl chr 6:47,457,554...47,472,961

G

isopentenyl-diphosphate delta isomerase 1

decreases expression

ISO

Antimycin A results in decreased expression of IDI1 mRNA

NCBI chr17:66,539,761...66,547,524
Ensembl chr17:66,539,763...66,547,524

G

immediate early response 3

increases expression

ISO

Antimycin A results in increased expression of IER3 mRNA

NCBI chr20:2,933,173...2,934,377
Ensembl chr20:2,933,174...2,934,377

G

interferon-induced protein 44-like

increases expression

ISO

Antimycin A results in increased expression of IFI44L mRNA

NCBI chr 2:243,328,629...243,366,404
Ensembl chr 2:243,328,723...243,366,404

G

interferon induced transmembrane protein 1

increases expression

ISO

Antimycin A results in increased expression of IFITM1 mRNA

NCBI chr 1:205,496,757...205,498,796
Ensembl chr 1:205,496,807...205,498,776

G

interferon induced transmembrane protein 3

decreases expression

ISO

Antimycin A results in decreased expression of IFITM3 mRNA

NCBI chr 1:205,540,649...205,541,758
Ensembl chr 1:205,481,168...205,547,920

G

interferon-related developmental regulator 1

increases expression

ISO

Antimycin A results in increased expression of IFRD1 mRNA

NCBI chr 6:62,996,560...63,044,996
Ensembl chr 6:62,996,562...63,016,131

G

interferon-related developmental regulator 2

increases expression

ISO

Antimycin A results in increased expression of IFRD2 mRNA

NCBI chr 8:117,139,612...117,144,834
Ensembl chr 8:117,139,550...117,144,836

G

insulin-like growth factor binding protein 2

decreases expression

ISO

Antimycin A results in decreased expression of IGFBP2 mRNA

NCBI chr 9:81,864,811...81,892,179
Ensembl chr 9:81,864,783...81,892,171

G

IKBKB interacting protein

increases expression

ISO

Antimycin A results in increased expression of IKBIP mRNA

NCBI chr 7:27,467,097...27,485,776
Ensembl chr 7:27,467,055...27,491,460

G

interleukin 1 beta

multiple interactions

ISO

Acetylcysteine inhibits the reaction [[Antimycin A co-treated with IL1B protein] results in increased expression of CXCL8 protein]; Antimycin A promotes the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; Antimycin A promotes the reaction [IL1B protein results in increased expression of CXCL8 protein]; Antimycin A promotes the reaction [IL1B protein results in increased expression of PTGS2 protein]; BAY 11-7085 inhibits the reaction [[Antimycin A co-treated with IL1B protein] results in increased expression of CXCL8 protein]; IL1B protein promotes the reaction [Antimycin A results in increased expression of PTGS2 protein]; Resveratrol inhibits the reaction [[Antimycin A co-treated with IL1B protein] results in increased expression of CXCL8 protein]

PMID:22549761 PMID:24609059

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 3 receptor subunit alpha

decreases expression

ISO

Antimycin A results in decreased expression of IL3RA mRNA

NCBI chr12:21,431,848...21,437,336
Ensembl chr12:21,431,848...21,437,250

G

interleukin 6

multiple interactions
increases expression

ISO

1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Antimycin A results in increased expression of and results in increased secretion of IL6 protein]; 23-epi-26-deoxyactein inhibits the reaction [Antimycin A results in increased expression of IL6 protein]; 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Antimycin A results in increased expression of and results in increased secretion of IL6 protein]; Antimycin A results in increased expression of and results in increased secretion of IL6 protein; Cyclosporine inhibits the reaction [Antimycin A results in increased expression of and results in increased secretion of IL6 protein]

PMID:21381053 PMID:21910134

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

interleukin 6 receptor

decreases expression

ISO

Antimycin A results in decreased expression of IL6R protein modified form

NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:177,582,164...177,645,221

G

internexin neuronal intermediate filament protein, alpha

decreases expression

ISO

Antimycin A results in decreased expression of INA mRNA

NCBI chr 1:255,838,129...255,849,680
Ensembl chr 1:255,838,129...255,849,680

G

inositol polyphosphate-1-phosphatase

increases expression

ISO

Antimycin A results in increased expression of INPP1 mRNA

NCBI chr 9:56,161,816...56,209,774
Ensembl chr 9:56,161,852...56,234,569

G

inositol polyphosphate-5-phosphatase F

decreases expression

ISO

Antimycin A results in decreased expression of INPP5F mRNA

NCBI chr 1:192,620,891...192,700,681
Ensembl chr 1:192,620,891...192,700,681

G

insulin induced gene 1

increases expression

ISO

Antimycin A results in increased expression of INSIG1 mRNA

NCBI chr 4:8,049,339...8,057,812
Ensembl chr 4:8,049,556...8,057,778

G

INSM transcriptional repressor 1

decreases expression

ISO

Antimycin A results in decreased expression of INSM1 mRNA

NCBI chr 3:154,093,310...154,096,243
Ensembl chr 3:154,092,734...154,096,047

G

importin 5

increases expression

ISO

Antimycin A results in increased expression of IPO5 mRNA

NCBI chr15:104,397,626...104,447,985
Ensembl chr15:104,397,276...104,447,985

G

interferon regulatory factor 1

increases expression

ISO

Antimycin A results in increased expression of IRF1 mRNA

NCBI chr10:38,417,935...38,424,946
Ensembl chr10:38,417,148...38,424,947

G

ISL LIM homeobox 1

decreases expression

ISO

Antimycin A results in decreased expression of ISL1 mRNA

NCBI chr 2:49,813,618...49,823,442
Ensembl chr 2:49,813,618...49,823,442

G

integrin subunit beta 7

increases expression

ISO

Antimycin A results in increased expression of ITGB7 mRNA

NCBI chr 7:135,225,962...135,243,522
Ensembl chr 7:135,226,555...135,243,597

G

inositol 1,4,5-trisphosphate receptor, type 2

decreases expression

ISO

Antimycin A results in decreased expression of ITPR2 mRNA

NCBI chr 4:180,759,325...181,165,361
Ensembl chr 4:180,760,442...181,164,763

G

jumonji domain containing 6, arginine demethylase and lysine hydroxylase

increases expression

ISO

Antimycin A results in increased expression of JMJD6 mRNA

NCBI chr10:102,539,935...102,545,986
Ensembl chr10:102,539,894...102,545,986

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

ISO

[Antimycin A co-treated with Paraquat] results in increased expression of JUN protein
Antimycin A results in increased expression of JUN protein

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

lysine demethylase 3A

decreases expression

ISO

Antimycin A results in decreased expression of KDM3A mRNA

NCBI chr 4:105,189,208...105,233,526
Ensembl chr 4:105,189,208...105,233,370

G

lysine demethylase 5B

decreases expression

ISO

Antimycin A results in decreased expression of KDM5B mRNA

NCBI chr13:48,554,367...48,625,721
Ensembl chr13:48,554,420...48,626,423

G

kinesin family member 14

increases expression

ISO

Antimycin A results in increased expression of KIF14 mRNA

NCBI chr13:50,478,646...50,542,256
Ensembl chr13:50,478,721...50,542,248

G

kinesin family member 15

increases expression

ISO

Antimycin A results in increased expression of KIF15 mRNA

NCBI chr 8:131,479,340...131,550,209
Ensembl chr 8:131,479,337...131,550,202

G

kinesin family member 20A

increases expression

ISO

Antimycin A results in increased expression of KIF20A mRNA

NCBI chr18:26,504,422...26,512,908
Ensembl chr18:26,504,072...26,512,909

G

kinesin family member 23

increases expression

ISO

Antimycin A results in increased expression of KIF23 mRNA

NCBI chr 8:71,293,439...71,321,911
Ensembl chr 8:71,293,482...71,320,856

G

kinesin family member 2C

increases expression

ISO

Antimycin A results in increased expression of KIF2C mRNA

NCBI chr 5:135,873,925...135,899,267
Ensembl chr 5:135,873,925...135,899,212

G

kinesin family member 5C

decreases expression

ISO

Antimycin A results in decreased expression of KIF5C mRNA

NCBI chr 3:54,441,266...54,591,630
Ensembl chr 3:54,441,310...54,594,813

G

KLF transcription factor 5

increases expression

ISO

Antimycin A results in increased expression of KLF5 mRNA

NCBI chr15:82,472,081...82,487,267
Ensembl chr15:82,472,065...82,487,262

G

KLF transcription factor 6

increases expression

ISO

Antimycin A results in increased expression of KLF6 mRNA

NCBI chr17:69,449,483...69,458,478
Ensembl chr17:69,441,493...69,498,601

G

kelch-like family member 24

increases expression

ISO

Antimycin A results in increased expression of KLHL24 mRNA

NCBI chr11:94,348,024...94,382,085
Ensembl chr11:94,351,157...94,382,050

G

kelch-like family member 9

decreases expression

ISO

Antimycin A results in decreased expression of KLHL9 mRNA

NCBI chr 5:108,449,492...108,453,676
Ensembl chr 5:108,437,583...108,454,140

G

keratin 17

increases expression

ISO

Antimycin A results in increased expression of KRT17 mRNA

NCBI chr10:85,679,068...85,683,792
Ensembl chr10:85,679,070...85,683,787

G

keratin 19

decreases expression

ISO

Antimycin A results in decreased expression of KRT19 mRNA

NCBI chr10:85,576,235...85,580,952
Ensembl chr10:85,576,235...85,580,952

G

kynurenine aminotransferase 3

decreases expression

ISO

Antimycin A results in decreased expression of KYAT3 mRNA

NCBI chr 2:234,362,306...234,407,646
Ensembl chr 2:234,362,322...234,407,878

G

L1 cell adhesion molecule

decreases expression

ISO

Antimycin A results in decreased expression of L1CAM mRNA

NCBI chr X:156,748,597...156,775,116
Ensembl chr X:156,748,597...156,775,077

G

lysosomal-associated membrane protein 1

multiple interactions
decreases expression

ISO

[PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of LAMP1 mRNA
Antimycin A results in decreased expression of LAMP1 mRNA

PMID:28366621 PMID:33512557

NCBI chr16:83,058,131...83,082,843
Ensembl chr16:83,058,385...83,075,159

G

leiomodin 1

decreases expression

ISO

Antimycin A results in decreased expression of LMOD1 mRNA

NCBI chr13:49,305,693...49,347,970
Ensembl chr13:49,305,830...49,348,116

G

lysyl oxidase-like 1

decreases expression

ISO

Antimycin A results in decreased expression of LOXL1 mRNA

NCBI chr 8:67,587,636...67,612,224
Ensembl chr 8:67,587,636...67,612,224

G

LDL receptor related protein 4

decreases expression

ISO

Antimycin A results in decreased expression of LRP4 mRNA

NCBI chr 3:97,885,373...97,939,366
Ensembl chr 3:97,885,400...97,939,370

G

leucine rich repeat containing 41

decreases expression

ISO

Antimycin A results in decreased expression of LRRC41 mRNA

NCBI chr 5:134,791,256...134,812,177
Ensembl chr 5:134,791,256...134,812,177

G

LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated

decreases expression

ISO

Antimycin A results in decreased expression of LSM6 mRNA

NCBI chr19:46,002,592...46,017,152

G

lumican

increases expression

ISO

Antimycin A results in increased expression of LUM mRNA

NCBI chr 7:34,245,323...34,252,510
Ensembl chr 7:34,245,360...34,252,508

G

microtubule-actin crosslinking factor 1

decreases expression

ISO

Antimycin A results in decreased expression of MACF1 mRNA

NCBI chr 5:140,908,829...141,234,127
Ensembl chr 5:140,908,837...141,233,890

G

MAF bZIP transcription factor F

increases expression

ISO

Antimycin A results in increased expression of MAFF mRNA

NCBI chr 7:112,792,787...112,804,139
Ensembl chr 7:112,791,416...112,804,147

G

microtubule-associated protein 1B

decreases expression

ISO

Antimycin A results in decreased expression of MAP1B mRNA

NCBI chr 2:32,551,423...32,644,471
Ensembl chr 2:32,551,423...32,657,094

G

microtubule-associated protein 1 light chain 3 beta

increases expression

ISO

Antimycin A results in increased expression of MAP1LC3B mRNA

NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358

G

microtubule-associated protein 2

decreases expression

ISO

Antimycin A results in decreased expression of MAP2 mRNA

NCBI chr 9:75,173,038...75,431,606
Ensembl chr 9:75,288,262...75,428,459

G

mitogen activated protein kinase kinase 4

decreases expression

ISO

Antimycin A results in decreased expression of MAP2K4 mRNA

NCBI chr10:50,842,348...50,947,063
Ensembl chr10:50,844,034...50,947,185

G

microtubule-associated protein 6

decreases expression

ISO

Antimycin A results in decreased expression of MAP6 mRNA

NCBI chr 1:162,980,339...163,046,548
Ensembl chr 1:162,980,181...163,046,548

G

mitogen activated protein kinase 14

multiple interactions

ISO

Antimycin A inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK14 protein]

NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294

G

mitogen activated protein kinase 3

decreases expression

ISO

Antimycin A results in decreased expression of MAPK3 mRNA

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

microtubule-associated protein, RP/EB family, member 3

decreases expression

ISO

Antimycin A results in decreased expression of MAPRE3 mRNA

NCBI chr 6:31,233,736...31,278,626
Ensembl chr 6:31,233,736...31,278,775

G

microtubule-associated protein tau

decreases expression

ISO

Antimycin A results in decreased expression of MAPT mRNA

NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,638,599...89,736,108

G

muscleblind-like splicing regulator 2

increases expression

ISO

Antimycin A results in increased expression of MBNL2 mRNA

NCBI chr15:103,792,134...103,949,827
Ensembl chr15:103,792,152...103,949,827

G

MCL1 apoptosis regulator, BCL2 family member

increases expression

ISO

Antimycin A results in increased expression of MCL1 mRNA

NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782

G

minichromosome maintenance complex component 7

increases expression

ISO

Antimycin A results in increased expression of MCM7 mRNA

NCBI chr12:22,155,921...22,163,320
Ensembl chr12:22,155,921...22,163,771

G

midkine

increases expression

ISO

Antimycin A results in increased expression of MDK mRNA

NCBI chr 3:98,356,789...98,358,960
Ensembl chr 3:98,356,789...98,358,743

G

MDM2 proto-oncogene

increases expression

ISO

Antimycin A results in increased expression of MDM2 mRNA

NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:55,176,560...55,200,791

G

malic enzyme 1

increases expression

ISO

Antimycin A results in increased expression of ME1 mRNA

NCBI chr 8:96,429,057...96,540,244
Ensembl chr 8:96,429,057...96,540,275

G

mediator complex subunit 21

increases expression

ISO

Antimycin A results in increased expression of MED21 mRNA

NCBI chr 4:181,291,191...181,314,504
Ensembl chr 4:181,291,271...181,298,234

G

MEFV innate immunity regulator, pyrin

increases expression

ISO

Antimycin A results in increased expression of MEFV mRNA

NCBI chr10:12,288,514...12,303,337
Ensembl chr10:12,293,782...12,303,333

G

meteorin, glial cell differentiation regulator

decreases expression

ISO

Antimycin A results in decreased expression of METRN mRNA

NCBI chr10:15,321,200...15,323,218
Ensembl chr10:15,321,200...15,323,642

G

marker of proliferation Ki-67

increases expression

ISO

Antimycin A results in increased expression of MKI67 mRNA

NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593

G

MLLT11, transcription factor 7 cofactor

decreases expression

ISO

Antimycin A results in decreased expression of MLLT11 mRNA

NCBI chr 2:185,484,791...185,493,961
Ensembl chr 2:185,484,793...185,493,961

G

matrix metallopeptidase 13

increases expression

ISO

Antimycin A results in increased expression of MMP13 mRNA

NCBI chr 8:12,782,829...12,793,108
Ensembl chr 8:12,782,813...12,793,105

G

matrix metallopeptidase 2

multiple interactions
increases activity

ISO

[Antimycin A results in increased abundance of Reactive Oxygen Species] which results in increased activity of MMP2 protein
Antimycin A results in increased activity of MMP2 protein

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

MNAT1 component of CDK activating kinase

decreases expression

ISO

Antimycin A results in decreased expression of MNAT1 mRNA

NCBI chr 6:97,550,566...97,706,598
Ensembl chr 6:97,550,543...97,706,595

G

MORN repeat containing 2

decreases expression

ISO

Antimycin A results in decreased expression of MORN2 mRNA

NCBI chr 6:14,718,799...14,725,281

G

MRE11 homolog, double strand break repair nuclease

decreases expression

ISO

Antimycin A results in decreased expression of MRE11 mRNA

NCBI chr 8:19,900,211...19,961,906
Ensembl chr 8:19,913,772...19,961,904

G

musashi RNA-binding protein 2

decreases expression

ISO

Antimycin A results in decreased expression of MSI2 mRNA

NCBI chr10:73,640,960...74,007,497
Ensembl chr10:73,646,139...74,007,552

G

MSL complex subunit 1

increases expression

ISO

Antimycin A results in increased expression of MSL1 mRNA

NCBI chr10:84,251,362...84,263,384
Ensembl chr10:84,251,642...84,261,971

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6

decreases expression

ISO

Antimycin A results in decreased expression of ND6 mRNA

NCBI chr MT:13,543...14,061
Ensembl chr MT:13,531...14,049

G

metastasis associated 1

decreases expression

ISO

Antimycin A results in decreased expression of MTA1 mRNA

NCBI chr 6:137,999,845...138,038,696
Ensembl chr 6:137,999,915...138,038,696

G

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase

increases expression

ISO

Antimycin A results in increased expression of MTHFD2 mRNA

NCBI chr 4:117,368,833...117,380,350
Ensembl chr 4:117,368,835...117,380,350

G

mechanistic target of rapamycin kinase

multiple interactions
increases expression

ISO

Acetylcysteine inhibits the reaction [Antimycin A results in increased expression of MTOR mRNA]

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435

G

MYB proto-oncogene like 2

increases expression

ISO

Antimycin A results in increased expression of MYBL2 mRNA

NCBI chr 3:172,124,765...172,153,221
Ensembl chr 3:172,116,550...172,153,221

G

MYC proto-oncogene, bHLH transcription factor

increases expression

ISO

Antimycin A results in increased expression of MYC mRNA

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028

G

MYC binding protein 2

decreases expression

ISO

Antimycin A results in decreased expression of MYCBP2 mRNA

NCBI chr15:86,352,061...86,590,126
Ensembl chr15:86,352,061...86,590,325

G

myogenic differentiation 1

decreases expression

ISO

Antimycin A results in decreased expression of MYOD1 mRNA

NCBI chr 1:106,021,161...106,023,871
Ensembl chr 1:106,021,161...106,023,871

G

myogenin

decreases expression

ISO

Antimycin A results in decreased expression of MYOG mRNA

NCBI chr13:48,297,476...48,300,065
Ensembl chr13:48,297,235...48,300,065

G

neuron navigator 1

decreases expression

ISO

Antimycin A results in decreased expression of NAV1 mRNA

NCBI chr13:49,418,755...49,671,117
Ensembl chr13:49,418,755...49,671,004

G

neural cell adhesion molecule 1

decreases expression

ISO

Antimycin A results in decreased expression of NCAM1 mRNA

NCBI chr 8:58,762,088...59,062,131
Ensembl chr 8:58,762,116...59,061,971

G

neurocan

decreases expression

ISO

Antimycin A results in decreased expression of NCAN mRNA

NCBI chr16:19,335,907...19,362,371
Ensembl chr16:19,335,907...19,362,371

G

non-SMC condensin I complex, subunit H

increases expression

ISO

Antimycin A results in increased expression of NCAPH mRNA

NCBI chr 3:134,825,271...134,852,502
Ensembl chr 3:134,825,271...134,852,502

G

N-myc downstream regulated 1

increases expression

ISO

Antimycin A results in increased expression of NDRG1 mRNA

NCBI chr 7:100,573,526...100,614,902
Ensembl chr 7:100,573,523...100,614,913

G

neurofilament light chain

decreases expression

ISO

Antimycin A results in decreased expression of NEFL mRNA

NCBI chr15:46,477,330...46,481,203
Ensembl chr15:46,458,204...46,482,515

G

NIMA-related kinase 2

increases expression

ISO

Antimycin A results in increased expression of NEK2 mRNA

NCBI chr13:105,936,809...105,950,054
Ensembl chr13:105,936,788...105,950,056

G

nuclear factor of activated T-cells 3

decreases expression

ISO

Antimycin A results in decreased expression of NFATC3 mRNA

NCBI chr19:50,870,464...50,944,992
Ensembl chr19:50,870,489...50,944,992

G

NFE2 like bZIP transcription factor 1

increases expression

ISO

Antimycin A results in increased expression of NFE2L1 mRNA

NCBI chr10:82,296,824...82,309,472
Ensembl chr10:82,292,508...82,309,375

G

NFE2 like bZIP transcription factor 2

multiple interactions
increases expression

ISO

Acetylcysteine inhibits the reaction [Antimycin A results in increased expression of NFE2L2 mRNA]

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

NFKB inhibitor alpha

multiple interactions

ISO

Antimycin A inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

nescient helix loop helix 1

decreases expression

ISO

Antimycin A results in decreased expression of NHLH1 mRNA

NCBI chr13:87,049,733...87,054,934
Ensembl chr13:87,049,629...87,055,033

G

nitrilase 1

decreases expression

ISO

Antimycin A results in decreased expression of NIT1 mRNA

NCBI chr13:86,302,334...86,305,770
Ensembl chr13:86,298,387...86,305,770

G

nicotinamide nucleotide transhydrogenase

decreases expression

ISO

Antimycin A results in decreased expression of NNT mRNA

NCBI chr 2:53,144,157...53,237,857
Ensembl chr 2:53,144,160...53,237,310

G

nucleolar protein 3

decreases expression

ISO

Antimycin A results in decreased expression of NOL3 mRNA

NCBI chr19:50,066,493...50,068,175
Ensembl chr19:50,063,986...50,068,722

G

NOP58 ribonucleoprotein

increases expression

ISO

Antimycin A results in increased expression of NOP58 mRNA

NCBI chr 9:68,614,992...68,638,911
Ensembl chr 9:68,615,010...68,638,909

G

notch receptor 3

decreases expression

ISO

Antimycin A results in decreased expression of NOTCH3 mRNA

NCBI chr 7:11,783,550...11,834,585
Ensembl chr 7:11,784,272...11,834,778

G

NPC intracellular cholesterol transporter 1

decreases expression

ISO

Antimycin A results in decreased expression of NPC1 mRNA

NCBI chr18:3,654,237...3,699,853
Ensembl chr18:3,654,237...3,699,800

G

neuronal pentraxin 1

increases expression

ISO

Antimycin A results in increased expression of NPTX1 mRNA

NCBI chr10:105,309,578...105,318,829
Ensembl chr10:105,309,578...105,318,863

G

NAD(P)H quinone dehydrogenase 1

increases expression
multiple interactions

ISO

Antimycin A results in increased expression of NQO1 mRNA
Acetylcysteine inhibits the reaction [Antimycin A results in increased expression of NQO1 mRNA]

PMID:33512557 PMID:35430258

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

nuclear receptor subfamily 2, group F, member 1

decreases expression

ISO

Antimycin A results in decreased expression of NR2F1 mRNA

NCBI chr 2:9,776,179...9,785,924
Ensembl chr 2:9,776,179...9,785,924

G

nuclear receptor subfamily 3, group C, member 1

increases expression

ISO

Antimycin A results in increased expression of NR3C1 mRNA

NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843

G

nuclear receptor subfamily 4, group A, member 2

increases expression

ISO

Antimycin A results in increased expression of NR4A2 mRNA

NCBI chr 3:62,098,739...62,115,926
Ensembl chr 3:62,098,743...62,106,769

G

nuclear receptor subfamily 5, group A, member 1

decreases expression

ISO

Antimycin A results in decreased expression of NR5A1 mRNA

NCBI chr 3:42,874,505...42,896,109
Ensembl chr 3:42,875,221...42,896,046

G

NRAS proto-oncogene, GTPase

decreases expression

ISO

Antimycin A results in decreased expression of NRAS mRNA

NCBI chr 2:193,271,399...193,282,023
Ensembl chr 2:193,271,430...193,278,543

G

neuronal cell adhesion molecule

decreases expression

ISO

Antimycin A results in decreased expression of NRCAM mRNA

NCBI chr 6:67,129,723...67,425,510
Ensembl chr 6:67,129,801...67,430,539

G

neuregulin 1

decreases expression

ISO

Antimycin A results in decreased expression of NRG1 mRNA

NCBI chr16:65,954,084...67,007,484
Ensembl chr16:65,953,865...66,999,849

G

neuropilin 1

decreases expression

ISO

Antimycin A results in decreased expression of NRP1 mRNA

NCBI chr19:73,256,557...73,411,705
Ensembl chr19:73,256,557...73,411,702

G

neurexin 1

decreases expression

ISO

Antimycin A results in decreased expression of NRXN1 mRNA

NCBI chr 6:8,931,360...10,077,381
Ensembl chr 6:8,935,523...10,077,374

G

5' nucleotidase, ecto

increases expression

ISO

Antimycin A results in increased expression of NT5E mRNA

NCBI chr 8:98,150,925...98,195,646
Ensembl chr 8:98,150,900...98,195,645

G

nucleoporin 50

increases expression

ISO

Antimycin A results in increased expression of NUP50 mRNA

NCBI chr 7:117,927,882...117,945,155
Ensembl chr 7:117,925,716...117,946,959

G

nuclear protein 1, transcriptional regulator

increases expression

ISO

Antimycin A results in increased expression of NUPR1 mRNA

NCBI chr 1:190,643,866...190,645,901
Ensembl chr 1:190,643,867...190,645,901

G

Opa interacting protein 5

increases expression

ISO

Antimycin A results in increased expression of OIP5 mRNA

NCBI chr 3:127,047,559...127,057,043
Ensembl chr 3:127,047,559...127,057,043

G

one cut homeobox 1

decreases expression

ISO

Antimycin A results in decreased expression of ONECUT1 mRNA

NCBI chr 8:84,480,066...84,507,848
Ensembl chr 8:84,480,305...84,508,124

G

oligophrenin 1

decreases expression

ISO

Antimycin A results in decreased expression of OPHN1 mRNA

NCBI chr X:67,639,956...68,018,217
Ensembl chr X:67,643,252...68,016,831

G

purinergic receptor P2X 3

decreases expression

ISO

Antimycin A results in decreased expression of P2RX3 mRNA

NCBI chr 3:90,487,506...90,531,315
Ensembl chr 3:90,487,506...90,531,794

G

platelet-activating factor acetylhydrolase 1b, catalytic subunit 3

decreases expression

ISO

Antimycin A results in decreased expression of PAFAH1B3 mRNA

NCBI chr 1:90,009,085...90,011,611
Ensembl chr 1:90,009,085...90,011,611

G

poly (ADP-ribose) polymerase 1

increases cleavage
multiple interactions

ISO

Antimycin A results in increased cleavage of PARP1 protein
[Antimycin A co-treated with Paraquat] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [Antimycin A results in increased cleavage of PARP1 protein]

PMID:16237197 PMID:32662599

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

poly (ADP-ribose) polymerase 2

increases expression

ISO

Antimycin A results in increased expression of PARP2 mRNA

NCBI chr15:26,494,722...26,517,893
Ensembl chr15:26,494,731...26,517,891

G

PDZ binding kinase

increases expression

ISO

Antimycin A results in increased expression of PBK mRNA

NCBI chr15:44,198,506...44,209,572
Ensembl chr15:44,198,544...44,209,570

G

protocadherin 8

increases expression

ISO

Antimycin A results in increased expression of PCDH8 mRNA

NCBI chr15:61,607,521...61,612,090
Ensembl chr15:61,607,521...61,612,097

G

protocadherin alpha 9

decreases expression

ISO

Antimycin A results in decreased expression of PCDHA9 mRNA

G

phosphoenolpyruvate carboxykinase 1

increases expression

ISO

Antimycin A results in increased expression of PCK1 mRNA

NCBI chr 3:182,348,572...182,354,521
Ensembl chr 3:182,348,572...182,354,561

G

programmed cell death 6 interacting protein

decreases expression

ISO

Antimycin A results in decreased expression of PDCD6IP mRNA

NCBI chr 8:122,469,223...122,524,993
Ensembl chr 8:122,469,223...122,524,993

G

protein disulfide isomerase family A, member 5

increases expression

ISO

Antimycin A results in increased expression of PDIA5 mRNA

NCBI chr11:78,777,436...78,892,370
Ensembl chr11:78,777,419...78,864,329

G

protein disulfide isomerase family A, member 6

increases expression

ISO

Antimycin A results in increased expression of PDIA6 mRNA

NCBI chr 6:45,791,704...45,808,947
Ensembl chr 6:45,791,678...45,810,091

G

pyruvate dehydrogenase kinase 4

increases expression

ISO

Antimycin A results in increased expression of PDK4 mRNA

NCBI chr 4:34,558,327...34,568,329
Ensembl chr 4:34,556,330...34,568,381

G

phosphatidylethanolamine binding protein 1

decreases expression

ISO

Antimycin A results in decreased expression of PEBP1 mRNA

NCBI chr12:44,946,307...44,967,890
Ensembl chr12:44,963,675...44,971,780

G

paternally expressed 10

decreases expression

ISO

Antimycin A results in decreased expression of PEG10 mRNA

NCBI chr 4:33,809,026...33,822,224
Ensembl chr 4:33,817,190...33,819,166
Ensembl chr 4:33,817,190...33,819,166

G

peroxisomal biogenesis factor 3

decreases expression

ISO

Antimycin A results in decreased expression of PEX3 mRNA

NCBI chr 1:7,912,508...7,954,474
Ensembl chr 1:9,732,492...9,774,576

G

phosphofructokinase, platelet

increases expression

ISO

Antimycin A results in increased expression of PFKP mRNA

NCBI chr17:68,639,749...68,704,055
Ensembl chr17:68,639,481...68,705,752

G

phosphoglycerate kinase 1

decreases expression

ISO

Antimycin A results in decreased expression of PGK1 mRNA

NCBI chr X:75,336,988...75,352,962
Ensembl chr X:75,336,687...75,352,959

G

phosphoglucomutase 3

increases expression

ISO

Antimycin A results in increased expression of PGM3 mRNA

NCBI chr 8:96,398,331...96,416,045
Ensembl chr 8:96,398,269...96,416,021

G

phosphoglycerate dehydrogenase

increases expression

ISO

Antimycin A results in increased expression of PHGDH mRNA

NCBI chr 2:188,595,700...188,624,789
Ensembl chr 2:188,595,700...188,624,789

G

phosphorylase kinase regulatory subunit beta

decreases expression

ISO

Antimycin A results in decreased expression of PHKB mRNA

NCBI chr19:37,179,937...37,383,979
Ensembl chr19:37,186,042...37,383,877

G

pleckstrin homology-like domain, family A, member 1

decreases expression

ISO

Antimycin A results in decreased expression of PHLDA1 mRNA

NCBI chr 7:48,853,690...48,855,894
Ensembl chr 7:48,853,260...48,857,542

G

PTEN induced kinase 1

multiple interactions
decreases expression

ISO

[PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of ATP6V1H mRNA; [PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of LAMP1 mRNA; [PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of TFEB mRNA; PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] affects the localization of PRKN protein]; PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] affects the localization of TFEB protein]; PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] results in increased expression of SQSTM1 mRNA]; PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]; Trifluoperazine affects the reaction [PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] affects the localization of TFEB protein]]
Antimycin A results in decreased expression of PINK1 mRNA

PMID:28366621 PMID:33512557

NCBI chr 5:155,813,838...155,825,950
Ensembl chr 5:155,813,838...155,825,950

G

phosphatidylinositol-5-phosphate 4-kinase type 2 beta

decreases expression

ISO

Antimycin A results in decreased expression of PIP4K2B mRNA

NCBI chr10:83,202,379...83,231,292
Ensembl chr10:83,197,287...83,231,292

G

phosphatidylinositol transfer protein, alpha

decreases expression

ISO

Antimycin A results in decreased expression of PITPNA mRNA

NCBI chr10:60,929,050...60,969,614
Ensembl chr10:60,929,007...60,971,830

G

phospholipid scramblase 3

decreases expression

ISO

Antimycin A results in decreased expression of PLSCR3 mRNA

NCBI chr10:55,064,349...55,070,120
Ensembl chr10:55,065,345...55,070,369

G

phorbol-12-myristate-13-acetate-induced protein 1

increases expression

ISO

Antimycin A results in increased expression of PMAIP1 mRNA

NCBI chr18:62,255,970...62,262,384
Ensembl chr18:62,255,598...62,262,382

G

DNA polymerase epsilon 3, accessory subunit

increases expression

ISO

Antimycin A results in increased expression of POLE3 mRNA

NCBI chr 5:80,989,508...80,992,742
Ensembl chr 5:80,989,511...80,992,742
Ensembl chr 7:80,989,511...80,992,742

G

RNA polymerase I and III subunit C

increases expression

ISO

Antimycin A results in increased expression of POLR1C mRNA

NCBI chr 9:22,233,318...22,237,430
Ensembl chr 9:22,233,305...22,237,428

G

RNA polymerase II, I and III subunit H

increases expression

ISO

Antimycin A results in increased expression of POLR2H mRNA

NCBI chr11:93,696,423...93,701,902
Ensembl chr10:105,353,444...105,354,241
Ensembl chr11:105,353,444...105,354,241

G

POTE ankyrin domain family member M

decreases expression

ISO

Antimycin A results in decreased expression of POTEM mRNA

NCBI chr16:20,193,646...20,311,924

G

POU class 4 homeobox 1

decreases expression

ISO

Antimycin A results in decreased expression of POU4F1 mRNA

NCBI chr15:87,668,328...87,674,643
Ensembl chr15:87,668,328...87,674,643

G

POU class 4 homeobox 2

decreases expression

ISO

Antimycin A results in decreased expression of POU4F2 mRNA

NCBI chr19:46,390,958...46,394,599
Ensembl chr19:46,390,958...46,394,599

G

peroxisome proliferator-activated receptor delta

decreases expression

ISO

Antimycin A results in decreased expression of PPARD mRNA

NCBI chr20:6,300,527...6,365,707
Ensembl chr20:6,352,183...6,365,707

G

PPARG coactivator 1 alpha

decreases expression

ISO

Antimycin A results in decreased expression of PPARGC1A protein

NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213

G

peptidylprolyl isomerase E

increases expression

ISO

Antimycin A results in increased expression of PPIE mRNA

NCBI chr 5:140,691,285...140,704,347
Ensembl chr 5:140,683,801...140,740,767

G

periplakin

decreases expression

ISO

Antimycin A results in decreased expression of PPL mRNA

NCBI chr10:10,957,388...11,003,035
Ensembl chr10:10,957,341...11,003,658

G

protein phosphatase, Mg2+/Mn2+ dependent, 1D

increases expression

ISO

Antimycin A results in increased expression of PPM1D mRNA

NCBI chr10:70,670,026...70,706,030
Ensembl chr10:70,670,020...70,706,256

G

protein phosphatase 1 catalytic subunit gamma

increases expression

ISO

Antimycin A results in increased expression of PPP1CC mRNA

NCBI chr12:40,043,822...40,061,301
Ensembl chr12:40,043,822...40,061,341

G

protein phosphatase 1, regulatory subunit 15A

increases expression

ISO

Antimycin A results in increased expression of PPP1R15A mRNA

PMID:19304788 PMID:33512557

NCBI chr 1:105,136,521...105,139,596
Ensembl chr 1:105,136,525...105,139,774

G

protein phosphatase 1, regulatory subunit 17

decreases expression

ISO

Antimycin A results in decreased expression of PPP1R17 mRNA

NCBI chr 4:86,544,024...86,560,839
Ensembl chr 4:86,544,121...86,560,835

G

PRA1 domain family, member 2

decreases expression

ISO

Antimycin A results in decreased expression of PRAF2 mRNA

NCBI chr X:17,445,313...17,447,950
Ensembl chr X:17,445,313...17,447,950

G

peroxiredoxin 3

decreases expression

ISO

Antimycin A results in decreased expression of PRDX3 mRNA

NCBI chr 1:269,987,691...270,000,111
Ensembl chr 1:269,987,685...270,000,300

G

protein kinase cAMP-activated catalytic subunit alpha

decreases expression

ISO

Antimycin A results in decreased expression of PRKACA mRNA

NCBI chr19:41,059,843...41,083,189
Ensembl chr19:41,059,843...41,086,494

G

protein kinase AMP-activated non-catalytic subunit gamma 1

decreases expression

ISO

Antimycin A results in decreased expression of PRKAG1 mRNA

NCBI chr 7:131,842,058...131,859,484
Ensembl chr 7:131,842,060...131,859,503

G

protein kinase cAMP-dependent type I regulatory subunit alpha

decreases expression

ISO

Antimycin A results in decreased expression of PRKAR1A mRNA

NCBI chr10:95,120,537...95,139,028
Ensembl chr10:95,120,487...95,139,025

G

protein kinase C, beta

decreases expression

ISO

Antimycin A results in decreased expression of PRKCB mRNA

NCBI chr 1:186,263,397...186,594,743
Ensembl chr 1:186,263,447...186,594,740

G

parkin RBR E3 ubiquitin protein ligase

multiple interactions
decreases expression

ISO

[oligomycin A co-treated with Antimycin A] affects the localization of PRKN protein; [Oligomycins co-treated with Antimycin A] affects the localization of PRKN protein; PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] affects the localization of PRKN protein]
Antimycin A results in decreased expression of PRKN mRNA

PMID:28366621 PMID:28673964 PMID:33512557

NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:51,210,330...52,430,304

G

proline rich 11

increases expression

ISO

Antimycin A results in increased expression of PRR11 mRNA

NCBI chr10:72,396,127...72,440,643
Ensembl chr10:72,398,667...72,418,275

G

phosphoserine aminotransferase 1

increases expression

ISO

Antimycin A results in increased expression of PSAT1 mRNA

NCBI chr 1:222,623,553...222,646,187
Ensembl chr 1:222,623,556...222,655,693

G

phosphatase and tensin homolog

multiple interactions
increases expression

ISO

Acetylcysteine inhibits the reaction [Antimycin A results in increased expression of PTEN mRNA]

NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330

G

prostaglandin-endoperoxide synthase 2

increases expression
multiple interactions

ISO

Antimycin A results in increased expression of PTGS2 protein
Antimycin A results in increased expression of PTGS2 mRNA
Antimycin A promotes the reaction [IL1B protein results in increased expression of PTGS2 protein]; IL1B protein promotes the reaction [Antimycin A results in increased expression of PTGS2 protein]

PMID:19304788 PMID:24609059

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

protein tyrosine phosphatase, receptor type, F

decreases expression

ISO

Antimycin A results in decreased expression of PTPRF mRNA

NCBI chr 5:137,027,376...137,109,405
Ensembl chr 5:137,028,164...137,095,426

G

PTTG1 regulator of sister chromatid separation, securin

increases expression

ISO

Antimycin A results in increased expression of PTTG1 mRNA

NCBI chr10:28,394,940...28,406,410
Ensembl chr10:28,394,814...28,406,309

G

RAB31, member RAS oncogene family

decreases expression

ISO

Antimycin A results in decreased expression of RAB31 mRNA

NCBI chr 9:112,693,596...112,828,104
Ensembl chr 9:112,693,597...112,828,092

G

RAD54 like

multiple interactions
increases expression

ISO

Acetylcysteine inhibits the reaction [Antimycin A results in increased expression of RAD54L mRNA]

NCBI chr 5:134,812,158...134,841,821
Ensembl chr 5:134,811,532...134,841,425

G

ral guanine nucleotide dissociation stimulator

decreases expression

ISO

Antimycin A results in decreased expression of RALGDS mRNA

NCBI chr 3:32,237,644...32,278,045
Ensembl chr 3:32,237,786...32,278,045

G

RB transcriptional corepressor like 1

decreases expression

ISO

Antimycin A results in decreased expression of RBL1 mRNA

NCBI chr 3:166,226,187...166,289,862
Ensembl chr 3:166,226,198...166,289,376

G

RNA binding motif protein 6

increases expression

ISO

Antimycin A results in increased expression of RBM6 mRNA

NCBI chr 8:117,327,607...117,431,397
Ensembl chr 8:117,331,325...117,431,397

G

ring-box 1

decreases expression

ISO

Antimycin A results in decreased expression of RBX1 mRNA

NCBI chr 7:114,870,893...114,881,194
Ensembl chr 7:114,870,972...114,881,191

G

REL proto-oncogene, NF-kB subunit

increases expression

ISO

Antimycin A results in increased expression of REL mRNA

NCBI chr14:101,891,238...101,922,324
Ensembl chr14:101,891,243...101,921,938

G

RELA proto-oncogene, NF-kB subunit

affects localization
multiple interactions

ISO

Antimycin A affects the localization of RELA protein
Antimycin A inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]

PMID:24316229 PMID:24609059

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

reelin

decreases expression

ISO

Antimycin A results in decreased expression of RELN mRNA

NCBI chr 4:13,628,440...14,055,201
Ensembl chr 4:13,628,399...14,055,162

G

regulator of G-protein signaling 2

increases expression

ISO

Antimycin A results in increased expression of RGS2 mRNA

NCBI chr13:58,350,063...58,352,666
Ensembl chr13:58,349,163...58,352,697

G

Rho family GTPase 1

increases expression

ISO

Antimycin A results in increased expression of RND1 mRNA

NCBI chr 7:131,700,321...131,707,392
Ensembl chr 7:131,700,321...131,707,392

G

ring finger protein 167

decreases expression

ISO

Antimycin A results in decreased expression of RNF167 mRNA

NCBI chr10:55,859,254...55,863,546
Ensembl chr10:55,859,297...55,863,905

G

RNA polymerase II associated protein 3

decreases expression

ISO

Antimycin A results in decreased expression of RPAP3 mRNA

NCBI chr 7:130,689,923...130,719,411
Ensembl chr 7:130,689,929...130,719,247

G

ribosomal protein L11

increases expression

ISO

Antimycin A results in increased expression of RPL11 mRNA

NCBI chr 5:153,557,592...153,561,230
Ensembl chr 5:153,557,597...153,561,127

G

ribosomal protein L17

increases expression

ISO

Antimycin A results in increased expression of RPL17 mRNA

NCBI chr18:70,856,275...70,859,388
Ensembl chr 3:111,722,010...111,722,638
Ensembl chr18:111,722,010...111,722,638

G

ribosomal protein L35

increases expression

ISO

Antimycin A results in increased expression of RPL35 mRNA

NCBI chr 3:43,162,960...43,166,485
Ensembl chr 3:43,162,764...43,165,947

G

ribosomal protein L36

increases expression

ISO

Antimycin A results in increased expression of RPL36 mRNA

NCBI chr 9:1,529,117...1,534,534
Ensembl chr 9:1,533,743...1,534,532
Ensembl chr 1:1,533,743...1,534,532

G

ribosomal protein L7A

increases expression

ISO

Antimycin A results in increased expression of RPL7A mRNA

NCBI chr 3:30,637,136...30,639,778
Ensembl chr 3:30,637,059...30,639,791
Ensembl chr18:30,637,059...30,639,791

G

ribosomal protein S10

decreases expression

ISO

Antimycin A results in decreased expression of RPS10 mRNA

NCBI chr20:5,696,135...5,700,863
Ensembl chr20:5,696,135...5,700,150
Ensembl chr 6:5,696,135...5,700,150

G

ribosomal protein S18

increases expression

ISO

Antimycin A results in increased expression of RPS18 mRNA

NCBI chr20:4,933,741...4,937,423
Ensembl chr20:4,917,095...4,937,423

G

ribosomal protein S2

increases expression

ISO

Antimycin A results in increased expression of RPS2 mRNA

NCBI chr10:14,251,841...14,253,697
Ensembl chr10:14,251,380...14,253,695

G

ribosomal protein s25

increases expression

ISO

Antimycin A results in increased expression of RPS25 mRNA

NCBI chr 8:53,630,333...53,632,810
Ensembl chr 8:53,629,861...53,632,808
Ensembl chr 8:53,629,861...53,632,808

G

ribosomal protein S3

increases expression

ISO

Antimycin A results in increased expression of RPS3 mRNA

NCBI chr 1:163,190,476...163,195,885
Ensembl chr 1:163,189,842...163,195,776

G

ribosomal protein S5

increases expression

ISO

Antimycin A results in increased expression of RPS5 mRNA

NCBI chr 1:82,610,965...82,615,262
Ensembl chr 1:82,610,965...82,615,262

G

ribosomal protein S7

increases expression

ISO

Antimycin A results in increased expression of RPS7 mRNA

NCBI chr 6:50,994,581...50,999,447

G

ribosomal protein SA

increases expression

ISO

Antimycin A results in increased expression of RPSA mRNA

NCBI chr 8:128,728,761...128,732,736
Ensembl chr 8:128,728,862...128,732,737

G

RRAD, Ras related glycolysis inhibitor and calcium channel regulator

increases expression

ISO

Antimycin A results in increased expression of RRAD mRNA

NCBI chr19:360,581...363,874
Ensembl chr19:360,973...363,871

G

ribonucleotide reductase regulatory subunit M2

decreases expression
increases expression

ISO

Antimycin A results in decreased expression of RRM2 mRNA
Antimycin A results in increased expression of RRM2 mRNA

PMID:19304788 PMID:33512557

NCBI chr 6:47,044,755...47,075,370
Ensembl chr 6:47,067,690...47,075,370

G

ribonucleotide reductase regulatory TP53 inducible subunit M2B

increases expression

ISO

Antimycin A results in increased expression of RRM2B mRNA

NCBI chr 7:70,962,008...70,993,726
Ensembl chr 7:70,965,590...70,993,670

G

ribosomal RNA processing 1B

increases expression

ISO

Antimycin A results in increased expression of RRP1B mRNA

NCBI chr20:10,122,825...10,148,404
Ensembl chr20:10,122,812...10,148,404

G

ribosomal RNA processing 8

increases expression

ISO

Antimycin A results in increased expression of RRP8 mRNA

NCBI chr 1:169,489,829...169,500,551
Ensembl chr 1:169,465,397...169,501,164

G

ribosome biogenesis regulator 1 homolog

increases expression

ISO

Antimycin A results in increased expression of RRS1 mRNA

NCBI chr 5:14,516,303...14,517,936
Ensembl chr 5:14,515,254...14,517,943

G

RT1 class Ia, locus A2

increases expression

ISO

Antimycin A results in increased expression of HLA-E mRNA

NCBI chr20:4,872,720...4,876,425

G

RT1 class I, locus CE16

increases expression

ISO

Antimycin A results in increased expression of HLA-A mRNA

NCBI chr20:3,261,656...3,265,548

G

reticulon 4 interacting protein 1

decreases expression

ISO

Antimycin A results in decreased expression of RTN4IP1 mRNA

NCBI chr20:48,964,903...49,004,235
Ensembl chr20:48,964,816...49,006,456

G

S100 calcium binding protein A13

increases expression

ISO

Antimycin A results in increased expression of S100A13 mRNA

NCBI chr 2:178,297,020...178,303,514
Ensembl chr 2:178,296,917...178,303,507

G

S100 calcium-binding protein A4

increases expression

ISO

Antimycin A results in increased expression of S100A4 mRNA

NCBI chr 2:178,388,529...178,390,838
Ensembl chr 2:178,388,526...178,390,837

G

SAC1 like phosphatidylinositide phosphatase

decreases expression

ISO

Antimycin A results in decreased expression of SACM1L mRNA

NCBI chr 8:132,053,465...132,109,857
Ensembl chr 8:132,053,049...132,109,857

G

spermidine/spermine N1-acetyl transferase 1

increases expression

ISO

Antimycin A results in increased expression of SAT1 mRNA

NCBI chr X:44,008,089...44,011,376
Ensembl chr X:44,006,781...44,011,374

G

SATB homeobox 1

decreases expression

ISO

Antimycin A results in decreased expression of SATB1 mRNA

NCBI chr 9:4,916,958...5,010,359
Ensembl chr 9:4,917,215...4,989,925

G

short coiled-coil protein

decreases expression

ISO

Antimycin A results in decreased expression of SCOC mRNA

NCBI chr19:41,564,166...41,593,932
Ensembl chr19:41,564,112...41,597,912

G

SEM1 26S proteasome subunit

increases expression

ISO

Antimycin A results in increased expression of SEM1 mRNA

NCBI chr 4:35,638,306...35,658,462
Ensembl chr 4:35,638,306...35,658,462

G

semaphorin 5A

increases expression

ISO

Antimycin A results in increased expression of SEMA5A mRNA

NCBI chr 2:85,020,724...85,451,938
Ensembl chr 2:85,020,724...85,451,938

G

semaphorin 6D

decreases expression

ISO

Antimycin A results in decreased expression of SEMA6D mRNA

NCBI chr 3:131,801,680...132,394,578
Ensembl chr 3:132,337,343...132,394,584

G

SERTA domain containing 1

increases expression

ISO

Antimycin A results in increased expression of SERTAD1 mRNA

NCBI chr 1:91,903,297...91,906,565
Ensembl chr 1:91,891,814...91,907,001

G

sestrin 2

increases expression

ISO

Antimycin A results in increased expression of SESN2 mRNA

NCBI chr 5:149,986,304...150,005,255
Ensembl chr 5:149,986,317...150,005,255

G

SH2 domain containing adaptor protein B

increases expression

ISO

Antimycin A results in increased expression of SHB mRNA

NCBI chr 5:64,473,694...64,581,072
Ensembl chr 5:64,473,694...64,581,072

G

SHC binding and spindle associated 1

increases expression

ISO

Antimycin A results in increased expression of SHCBP1 mRNA

NCBI chr16:91,373,843...91,405,409
Ensembl chr16:91,373,871...91,405,409

G

sirtuin 3

increases expression
multiple interactions

ISO

Antimycin A results in increased expression of SIRT3 mRNA
Acetylcysteine inhibits the reaction [Antimycin A results in increased expression of SIRT3 mRNA]

NCBI chr 1:205,371,703...205,394,145
Ensembl chr 1:205,371,710...205,394,076

G

SIX homeobox 1

decreases expression

ISO

Antimycin A results in decreased expression of SIX1 mRNA

NCBI chr 6:97,482,617...97,487,853
Ensembl chr 6:97,482,617...97,487,853

G

solute carrier family 11 member 2

decreases expression

ISO

Antimycin A results in decreased expression of SLC11A2 mRNA

NCBI chr 7:133,381,878...133,429,921
Ensembl chr 7:133,381,878...133,418,941

G

solute carrier family 17 member 6

decreases expression

ISO

Antimycin A results in decreased expression of SLC17A6 mRNA

NCBI chr 1:110,348,447...110,388,499
Ensembl chr 1:110,348,447...110,388,498

G

solute carrier family 18 member A2

increases expression

ISO

Antimycin A results in increased expression of SLC18A2 mRNA

NCBI chr 1:268,399,815...268,435,229
Ensembl chr 1:268,400,016...268,435,231

G

solute carrier family 1 member 2

decreases expression

ISO

Antimycin A results in decreased expression of SLC1A2 mRNA

NCBI chr 3:109,460,109...109,590,445
Ensembl chr 3:109,459,630...109,605,249

G

solute carrier family 25 member 4

decreases expression

ISO

Antimycin A results in decreased expression of SLC25A4 mRNA

NCBI chr16:52,805,521...52,809,316
Ensembl chr16:52,805,523...52,811,700

G

solute carrier family 2 member 6

decreases expression

ISO

Antimycin A results in decreased expression of SLC2A6 mRNA

NCBI chr 3:30,746,472...30,753,287
Ensembl chr 3:30,745,995...30,753,287

G

solute carrier family 30 member 1

increases expression

ISO

Antimycin A results in increased expression of SLC30A1 mRNA

NCBI chr13:106,022,019...106,025,892
Ensembl chr13:106,022,019...106,025,892

G

solute carrier family 35, member A5

decreases expression

ISO

Antimycin A results in decreased expression of SLC35A5 mRNA

NCBI chr11:69,159,435...69,180,503
Ensembl chr11:69,159,384...69,180,502

G

solute carrier family 3 member 2

increases expression

ISO

Antimycin A results in increased expression of SLC3A2 mRNA

NCBI chr 1:215,033,601...215,048,064
Ensembl chr 1:215,033,601...215,048,064

G

solute carrier family 6 member 2

increases expression

ISO

Antimycin A results in increased expression of SLC6A2 mRNA

NCBI chr19:30,183,289...30,228,292
Ensembl chr19:30,183,383...30,223,348

G

solute carrier family 7 member 5

increases expression

ISO

Antimycin A results in increased expression of SLC7A5 mRNA

NCBI chr19:66,843,808...66,872,412
Ensembl chr19:66,843,808...66,872,412

G

structural maintenance of chromosomes 4

increases expression

ISO

Antimycin A results in increased expression of SMC4 mRNA

NCBI chr 2:155,550,262...155,578,695
Ensembl chr 2:155,550,262...155,581,937

G

snail family transcriptional repressor 2

increases expression

ISO

Antimycin A results in increased expression of SNAI2 mRNA

PMID:19304788 PMID:33512557

NCBI chr11:99,686,934...99,690,349
Ensembl chr11:99,686,934...99,690,349

G

synuclein alpha

increases expression

ISO

Antimycin A results in increased expression of SNCA mRNA

NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:91,026,474...91,126,315

G

small nuclear ribonucleoprotein D3 polypeptide

increases expression

ISO

Antimycin A results in increased expression of SNRPD3 mRNA

NCBI chr20:13,129,555...13,145,100
Ensembl chr20:13,109,294...13,145,763

G

sorting nexin 13

decreases expression

ISO

Antimycin A results in decreased expression of SNX13 mRNA

NCBI chr 6:57,478,139...57,589,624
Ensembl chr 6:57,434,273...57,589,624

G

sorting nexin 7

decreases expression

ISO

Antimycin A results in decreased expression of SNX7 mRNA

NCBI chr 2:208,528,041...208,612,597
Ensembl chr 2:208,528,049...208,613,075

G

suppressor of cytokine signaling 2

decreases expression

ISO

Antimycin A results in decreased expression of SOCS2 mRNA

NCBI chr 7:31,890,564...31,932,092
Ensembl chr 7:31,874,463...31,930,423

G

suppressor of cytokine signaling 3

increases expression

ISO

Antimycin A results in increased expression of SOCS3 mRNA

NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,690,976...103,704,825

G

superoxide dismutase 2

multiple interactions
increases expression

ISO
EXP

Acetylcysteine inhibits the reaction [Antimycin A results in increased expression of SOD2 mRNA]; Antimycin A inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]
Antimycin A results in increased expression of SOD2 mRNA; Antimycin A results in increased expression of SOD2 protein
[Antimycin A co-treated with Resveratrol] affects the expression of SOD2 mRNA; [Antimycin A co-treated with Resveratrol] affects the expression of SOD2 protein; FOXO1 mutant form affects the reaction [[Antimycin A co-treated with Resveratrol] affects the expression of SOD2 mRNA]; FOXO1 mutant form affects the reaction [[Antimycin A co-treated with Resveratrol] affects the expression of SOD2 protein]; FOXO3 mutant form affects the reaction [[Antimycin A co-treated with Resveratrol] affects the expression of SOD2 mRNA]; FOXO3 mutant form affects the reaction [[Antimycin A co-treated with Resveratrol] affects the expression of SOD2 protein]; FOXO4 mutant form affects the reaction [[Antimycin A co-treated with Resveratrol] affects the expression of SOD2 mRNA]; FOXO4 mutant form affects the reaction [[Antimycin A co-treated with Resveratrol] affects the expression of SOD2 protein]
Antimycin A inhibits the reaction [Lipopolysaccharides results in increased expression of SOD2 mRNA]

PMID:11264281 PMID:22718889 PMID:24040102 PMID:35430258

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

sperm associated antigen 5

increases expression

ISO

Antimycin A results in increased expression of SPAG5 mRNA

NCBI chr10:63,693,300...63,714,813
Ensembl chr10:63,696,466...63,714,811

G

SPC25 component of NDC80 kinetochore complex

increases expression

ISO

Antimycin A results in increased expression of SPC25 mRNA

NCBI chr 3:74,337,872...74,396,825
Ensembl chr 3:74,383,548...74,396,718

G

SAM pointed domain containing ets transcription factor

decreases expression

ISO

Antimycin A results in decreased expression of SPDEF mRNA

NCBI chr20:5,773,236...5,787,685
Ensembl chr20:5,773,231...5,787,689

G

sequestosome 1

increases expression
multiple interactions

ISO

Antimycin A results in increased expression of SQSTM1 mRNA
[oligomycin A co-treated with Antimycin A] results in increased expression of SQSTM1 mRNA; PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] results in increased expression of SQSTM1 mRNA]

PMID:19304788 PMID:28366621

NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750

G

steroid 5 alpha-reductase 1

decreases expression

ISO

Antimycin A results in decreased expression of SRD5A1 mRNA

NCBI chr 1:35,514,914...35,548,898
Ensembl chr 1:35,514,846...35,548,903

G

SLIT-ROBO Rho GTPase activating protein 3

decreases expression

ISO

Antimycin A results in decreased expression of SRGAP3 mRNA

NCBI chr 4:147,391,082...147,626,407
Ensembl chr 4:147,395,880...147,625,713

G

serine and arginine rich splicing factor 10

increases expression

ISO

Antimycin A results in increased expression of SRSF10 mRNA

NCBI chr 5:153,372,307...153,386,520
Ensembl chr 5:153,372,316...153,386,513

G

signal sequence receptor subunit 1

decreases expression

ISO

Antimycin A results in decreased expression of SSR1 mRNA

NCBI chr17:27,039,203...27,067,352
Ensembl chr17:27,039,269...27,067,348

G

steroidogenic acute regulatory protein

decreases expression

ISO

Antimycin A results in decreased expression of STAR protein

NCBI chr16:72,969,824...72,974,447
Ensembl chr16:72,961,518...72,974,447

G

signal transducer and activator of transcription 4

decreases expression

ISO

Antimycin A results in decreased expression of STAT4 mRNA

NCBI chr 9:56,964,617...57,080,523
Ensembl chr 9:56,911,523...57,077,346

G

STEAP family member 1

decreases expression

ISO

Antimycin A results in decreased expression of STEAP1 mRNA

NCBI chr 4:29,231,809...29,242,317
Ensembl chr 4:29,231,753...29,242,317

G

serine/threonine kinase 25

decreases expression

ISO

Antimycin A results in decreased expression of STK25 mRNA

NCBI chr 9:101,609,218...101,621,458
Ensembl chr 9:101,609,221...101,621,359

G

SWT1 RNA endoribonuclease homolog

decreases expression

ISO

Antimycin A results in decreased expression of SWT1 mRNA

NCBI chr13:63,452,494...63,509,982
Ensembl chr13:66,002,479...66,059,962

G

synaptophysin

decreases expression

ISO

Antimycin A results in decreased expression of SYP mRNA

NCBI chr X:17,521,348...17,536,449
Ensembl chr X:17,521,348...17,536,984

G

synaptotagmin-like 1

increases expression

ISO

Antimycin A results in increased expression of SYTL1 mRNA

NCBI chr 5:150,736,425...150,746,840
Ensembl chr 5:150,736,425...150,746,840

G

transforming, acidic coiled-coil containing protein 3

increases expression

ISO

Antimycin A results in increased expression of TACC3 mRNA

NCBI chr14:81,275,755...81,289,894
Ensembl chr14:81,275,755...81,289,698

G

TATA-box binding protein associated factor 7

increases expression

ISO

Antimycin A results in increased expression of TAF7 mRNA

NCBI chr18:29,704,182...29,713,382
Ensembl chr18:29,705,920...29,712,712

G

TATA-box binding protein associated factor 9

increases expression

ISO

Antimycin A results in increased expression of TAF9 mRNA

NCBI chr 2:33,528,388...33,532,395
Ensembl chr 2:33,531,368...33,536,078

G

transgelin

increases expression

ISO

Antimycin A results in increased expression of TAGLN mRNA

NCBI chr 8:55,121,647...55,127,121
Ensembl chr 8:55,121,301...55,127,563

G

TAP binding protein

decreases expression

ISO

Antimycin A results in decreased expression of TAPBP mRNA

NCBI chr20:4,958,821...4,967,958
Ensembl chr20:4,959,926...4,971,834

G

TAR (HIV-1) RNA binding protein 1

decreases expression

ISO

Antimycin A results in decreased expression of TARBP1 mRNA

NCBI chr19:71,295,588...71,346,595
Ensembl chr19:71,296,372...71,346,778

G

transcription elongation factor A like 9

increases expression

ISO

Antimycin A results in increased expression of TCEAL9 mRNA

NCBI chr X:104,037,274...104,039,345
Ensembl chr X:104,032,421...104,041,562

G

transcription factor 4

decreases expression

ISO

Antimycin A results in decreased expression of TCF4 mRNA

NCBI chr18:65,216,840...65,563,186
Ensembl chr18:65,216,849...65,558,401

G

T-cell leukemia translocation altered

decreases expression

ISO

Antimycin A results in decreased expression of TCTA mRNA

NCBI chr 8:117,867,153...117,871,132
Ensembl chr 8:117,867,153...117,871,331

G

tectonic family member 1

decreases expression

ISO

Antimycin A results in decreased expression of TCTN1 mRNA

NCBI chr12:39,970,554...40,003,727
Ensembl chr12:39,970,621...40,003,725

G

transcription factor A, mitochondrial

decreases expression

ISO

Antimycin A results in decreased expression of TFAM mRNA

NCBI chr20:17,355,373...17,367,422
Ensembl chr20:17,355,363...17,369,877

G

transcription factor AP-2 alpha

decreases expression

ISO

Antimycin A results in decreased expression of TFAP2A mRNA

NCBI chr17:24,230,064...24,253,219
Ensembl chr17:24,229,910...24,253,219

G

transcription factor Dp-1

decreases expression

ISO

Antimycin A results in decreased expression of TFDP1 mRNA

NCBI chr16:82,864,220...82,903,166
Ensembl chr16:82,864,226...82,902,996

G

transcription factor EB

multiple interactions

ISO

[oligomycin A co-treated with Antimycin A] affects the localization of TFEB protein; [PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of TFEB mRNA; PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] affects the localization of TFEB protein]; Trifluoperazine affects the reaction [PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] affects the localization of TFEB protein]]

NCBI chr 9:20,696,440...20,752,265
Ensembl chr 9:20,696,441...20,727,863

G

transforming growth factor, beta 1

increases expression

ISO

Antimycin A results in increased expression of TGFB1 mRNA

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

transforming growth factor, beta 3

decreases expression

ISO

Antimycin A results in decreased expression of TGFB3 mRNA

NCBI chr 6:111,435,170...111,457,646
Ensembl chr 6:111,435,170...111,456,946

G

TCDD-inducible poly(ADP-ribose) polymerase

increases expression

ISO

Antimycin A results in increased expression of TIPARP mRNA

NCBI chr 2:152,063,769...152,090,414
Ensembl chr 2:152,063,751...152,090,406

G

timeless interacting protein

increases expression

ISO

Antimycin A results in increased expression of TIPIN mRNA

NCBI chr 8:73,676,020...73,696,620
Ensembl chr 8:73,676,091...73,696,620

G

tousled-like kinase 2

decreases expression

ISO

Antimycin A results in decreased expression of TLK2 mRNA

NCBI chr10:90,648,623...90,748,427
Ensembl chr10:90,653,851...90,748,428

G

TM2 domain containing 2

decreases expression

ISO

Antimycin A results in decreased expression of TM2D2 mRNA

NCBI chr16:67,016,683...67,022,206
Ensembl chr16:73,719,332...73,724,981

G

transmembrane 9 superfamily member 3

decreases expression

ISO

Antimycin A results in decreased expression of TM9SF3 mRNA

NCBI chr 1:249,981,458...250,034,247
Ensembl chr 1:249,981,458...250,034,247

G

transmembrane protein 185A

decreases expression

ISO

Antimycin A results in decreased expression of TMEM185A mRNA

NCBI chr X:154,187,833...154,212,557
Ensembl chr X:154,187,833...154,221,546

G

tenascin C

decreases expression

ISO

Antimycin A results in decreased expression of TNC mRNA

NCBI chr 5:82,391,340...82,476,197
Ensembl chr 5:82,391,340...82,476,131

G

tumor necrosis factor

increases expression
multiple interactions

ISO

Antimycin A results in increased expression of TNF protein
Antimycin A inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; Antimycin A promotes the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Antimycin A promotes the reaction [TNF protein results in increased expression of CXCL8 protein]
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Antimycin A results in increased expression of and results in increased secretion of TNF protein]; 23-epi-26-deoxyactein inhibits the reaction [Antimycin A results in increased expression of TNF protein]; 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Antimycin A results in increased expression of and results in increased secretion of TNF protein]; Antimycin A inhibits the reaction [TNF protein results in increased expression of CXCL1 mRNA]; Antimycin A inhibits the reaction [TNF protein results in increased expression of TNFAIP3 mRNA]; Antimycin A inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; Antimycin A inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]; Antimycin A results in increased expression of and results in increased secretion of TNF protein; Cyclosporine inhibits the reaction [Antimycin A results in increased expression of and results in increased secretion of TNF protein]; sciadopitysin inhibits the reaction [Antimycin A results in increased expression of TNF protein]

PMID:11264281 PMID:21381053 PMID:21910134 PMID:22549761 PMID:23624148 More...

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF alpha induced protein 3

multiple interactions

ISO

Antimycin A inhibits the reaction [TNF protein results in increased expression of TNFAIP3 mRNA]

NCBI chr 1:15,528,921...15,543,993
Ensembl chr 1:15,528,921...15,543,979

G

TNF receptor superfamily member 11B

decreases expression

ISO

Antimycin A results in decreased expression of TNFRSF11B protein

NCBI chr 7:87,456,318...87,484,324
Ensembl chr 7:87,456,319...87,485,075

G

TNF receptor superfamily member 12A

increases expression

ISO

Antimycin A results in increased expression of TNFRSF12A mRNA

NCBI chr10:13,211,670...13,213,666
Ensembl chr10:13,211,673...13,213,704

G

TNF superfamily member 11

increases expression
multiple interactions

ISO

Antimycin A results in increased expression of TNFSF11 protein
23-epi-26-deoxyactein inhibits the reaction [Antimycin A results in increased expression of TNFSF11 protein]; 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Antimycin A results in increased expression of TNFSF11 protein]

PMID:21381053 PMID:21910134

NCBI chr15:60,083,008...60,114,479
Ensembl chr15:60,083,008...60,114,479

G

TNF superfamily member 13b

increases expression

ISO

Antimycin A results in increased expression of TNFSF13B mRNA

NCBI chr16:86,164,377...86,195,072
Ensembl chr16:86,164,377...86,194,499

G

TNFAIP3 interacting protein 1

decreases expression

ISO

Antimycin A results in decreased expression of TNIP1 mRNA

NCBI chr10:39,537,759...39,585,038
Ensembl chr10:39,537,437...39,585,158

G

tenascin XB

decreases expression

ISO

Antimycin A results in decreased expression of TNXB mRNA

Ensembl chr20:4,031,082...4,090,128

G

DNA topoisomerase II alpha

increases expression

ISO

Antimycin A results in increased expression of TOP2A mRNA

NCBI chr10:84,441,954...84,473,093
Ensembl chr10:84,441,954...84,473,366

G

tumor protein p53

multiple interactions
increases response to substance
increases acetylation

ISO

6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [Antimycin A results in increased acetylation of TRP53 protein]; Resveratrol inhibits the reaction [Antimycin A results in increased acetylation of TRP53 protein]
TRP53 protein results in increased susceptibility to Antimycin A

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

tumor protein p53 inducible protein 3

increases expression

ISO

Antimycin A results in increased expression of TP53I3 mRNA

NCBI chr 6:33,537,779...33,545,204

G

TPX2, microtubule nucleation factor

increases expression

ISO

Antimycin A results in increased expression of TPX2 mRNA

NCBI chr 3:161,778,709...161,820,941
Ensembl chr 3:161,778,742...161,820,724

G

tribbles pseudokinase 1

increases expression

ISO

Antimycin A results in increased expression of TRIB1 mRNA

NCBI chr 7:93,096,001...93,102,547
Ensembl chr 7:93,095,973...93,117,480

G

tribbles pseudokinase 3

increases expression

ISO

Antimycin A results in increased expression of TRIB3 mRNA

PMID:19304788 PMID:33512557

NCBI chr 3:161,269,939...161,275,533
Ensembl chr 3:161,269,955...161,274,802

G

tripartite motif-containing 13

decreases expression

ISO

Antimycin A results in decreased expression of TRIM13 mRNA

NCBI chr15:39,909,587...39,948,719
Ensembl chr15:39,902,284...39,958,892

G

thyroid hormone receptor interactor 12

decreases expression

ISO

Antimycin A results in decreased expression of TRIP12 mRNA

NCBI chr 9:93,364,791...93,491,015
Ensembl chr 9:93,364,791...93,490,159

G

transient receptor potential cation channel, subfamily V, member 1

decreases expression

ISO

Antimycin A results in decreased expression of TRPV1 mRNA

NCBI chr10:58,349,936...58,375,021
Ensembl chr10:58,340,223...58,375,021

G

tumor susceptibility 101

decreases expression

ISO

Antimycin A results in decreased expression of TSG101 mRNA

NCBI chr 1:106,549,035...106,578,859
Ensembl chr 1:106,535,021...106,578,775

G

teashirt zinc finger homeobox 2

decreases expression

ISO

Antimycin A results in decreased expression of TSHZ2 mRNA

NCBI chr 3:178,824,221...179,271,151
Ensembl chr 3:178,824,994...179,269,641

G

tsukushi, small leucine rich proteoglycan

decreases expression

ISO

Antimycin A results in decreased expression of TSKU mRNA

NCBI chr 1:162,071,459...162,082,972
Ensembl chr 1:162,064,126...162,089,272

G

tetraspanin 3

decreases expression

ISO

Antimycin A results in decreased expression of TSPAN3 mRNA

NCBI chr 8:65,442,100...65,465,961
Ensembl chr 8:65,442,101...65,465,844

G

thiosulfate sulfurtransferase

decreases expression

ISO

Antimycin A results in decreased expression of TST mRNA

NCBI chr 7:111,828,557...111,836,980
Ensembl chr 7:111,828,558...111,837,116

G

tubulin, beta 2A class IIa

decreases expression

ISO

Antimycin A results in decreased expression of TUBB2A mRNA

PMID:33512557 PMID:33770205

NCBI chr17:31,002,186...31,006,057
Ensembl chr17:30,983,387...31,006,838

G

tubulin, beta 2B class IIb

decreases expression

ISO

Antimycin A results in decreased expression of TUBB2B mRNA

NCBI chr17:30,953,086...30,956,133
Ensembl chr17:30,952,923...30,955,990

G

terminal uridylyl transferase 7

decreases expression

ISO

Antimycin A results in decreased expression of TUT7 mRNA

NCBI chr17:4,854,553...4,908,758
Ensembl chr17:4,855,936...4,909,070

G

thioredoxin domain containing 5

increases expression

ISO

Antimycin A results in increased expression of TXNDC5 mRNA

NCBI chr17:26,495,467...26,523,608
Ensembl chr17:26,490,047...26,523,597

G

thioredoxin interacting protein

decreases expression

ISO

Antimycin A results in decreased expression of TXNIP mRNA

NCBI chr 2:186,781,933...186,785,736
Ensembl chr 2:186,781,163...186,785,731

G

thioredoxin reductase 1

increases expression

ISO

Antimycin A results in increased expression of TXNRD1 mRNA

NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:22,719,317...22,739,817

G

thioredoxin reductase 2

increases expression

ISO

Antimycin A results in increased expression of TXNRD2 mRNA

NCBI chr11:96,024,321...96,072,475
Ensembl chr11:96,024,324...96,072,475

G

thymidylate synthetase

increases expression

ISO

Antimycin A results in increased expression of TYMS mRNA

NCBI chr 9:120,760,057...120,776,149
Ensembl chr 9:120,763,386...120,776,097

G

ubiquitin B

increases expression

ISO

Antimycin A results in increased expression of UBB mRNA

NCBI chr10:47,746,923...47,748,628
Ensembl chr10:47,727,701...47,750,335

G

ubiquitin-conjugating enzyme E2C

increases expression

ISO

Antimycin A results in increased expression of UBE2C mRNA

NCBI chr 3:173,925,975...173,928,375
Ensembl chr 3:173,925,934...173,932,678

G

ubiquitin conjugating enzyme E2 Q2

decreases expression

ISO

Antimycin A results in decreased expression of UBE2Q2 mRNA

NCBI chr 8:64,414,502...64,474,425
Ensembl chr 8:64,414,301...64,474,418

G

ubiquitin C-terminal hydrolase L1

decreases expression

ISO

Antimycin A results in decreased expression of UCHL1 mRNA

NCBI chr14:41,838,859...41,849,743
Ensembl chr14:41,838,861...41,849,417

G

uncoupling protein 2

increases expression
decreases expression

ISO

Antimycin A results in increased expression of UCP2 protein
Antimycin A results in decreased expression of UCP2 mRNA; Antimycin A results in decreased expression of UCP2 protein

PMID:18082129 PMID:34302933

NCBI chr 1:164,251,373...164,257,742
Ensembl chr 1:164,251,373...164,257,743

G

unc-51 like autophagy activating kinase 1

increases expression
multiple interactions

ISO

Antimycin A results in increased expression of ULK1 mRNA; Antimycin A results in increased expression of ULK1 protein
Antimycin A inhibits the reaction [Cycloheximide results in decreased expression of ULK1 protein]; Antimycin A inhibits the reaction [Nitrogen deficiency results in decreased expression of ULK1 protein]; Antimycin A promotes the reaction [ATG13 protein results in increased expression of ULK1 protein]; ATG13 protein promotes the reaction [Antimycin A results in increased expression of ULK1 protein]; Cycloheximide inhibits the reaction [Antimycin A results in increased expression of ULK1 protein]; Nitrogen deficiency inhibits the reaction [Antimycin A results in increased expression of ULK1 protein]

NCBI chr12:51,511,492...51,537,746
Ensembl chr12:51,511,492...51,537,746

G

unc-50 inner nuclear membrane RNA binding protein

decreases expression

ISO

Antimycin A results in decreased expression of UNC50 mRNA

NCBI chr 9:39,664,944...39,674,369
Ensembl chr 9:47,160,796...47,168,688

G

ubiquinol-cytochrome c reductase complex assembly factor 3

decreases expression

ISO

Antimycin A results in decreased expression of UQCC3 mRNA

NCBI chr 1:205,773,591...205,774,369
Ensembl chr 1:215,202,700...215,203,478

G

ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1

decreases expression

ISO

Antimycin A results in decreased expression of UQCRFS1 mRNA

NCBI chr17:34,173,787...34,190,952
Ensembl chr17:34,173,833...34,190,950

G

UTP14A small subunit processome component

increases expression

ISO

Antimycin A results in increased expression of UTP14A mRNA

NCBI chr X:132,317,163...132,342,524
Ensembl chr X:132,317,159...132,342,523

G

urotensin 2

increases expression

ISO

Antimycin A results in increased expression of UTS2 mRNA

NCBI chr 5:166,725,471...166,739,063
Ensembl chr 5:166,733,671...166,739,059

G

VAMP associated protein B and C

decreases expression

ISO

Antimycin A results in decreased expression of VAPB mRNA

PMID:33512557 PMID:34642769

NCBI chr 3:182,954,247...182,997,018
Ensembl chr 3:182,954,240...183,028,619

G

vav guanine nucleotide exchange factor 3

decreases expression

ISO

Antimycin A results in decreased expression of VAV3 mRNA

NCBI chr 2:199,699,861...200,042,344
Ensembl chr 2:199,700,445...200,042,343

G

voltage-dependent anion channel 1

decreases expression

ISO

Antimycin A results in decreased expression of VDAC1 mRNA

NCBI chr10:37,029,377...37,060,542
Ensembl chr10:37,023,145...37,060,541

G

vascular endothelial growth factor A

decreases expression
multiple interactions
increases expression

ISO

Antimycin A results in decreased expression of VEGFA protein
Acetylcysteine inhibits the reaction [Antimycin A results in increased expression of VEGFA mRNA]

PMID:20116850 PMID:33512557 PMID:35430258

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

G

vestigial-like family member 4

decreases expression

ISO

Antimycin A results in decreased expression of VGLL4 mRNA

NCBI chr 4:149,598,151...149,711,186
Ensembl chr 4:149,598,891...149,660,594

G

vimentin

increases expression

ISO

Antimycin A results in increased expression of VIM mRNA

NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746

G

vacuolar protein sorting 72 homolog

decreases expression

ISO

Antimycin A results in decreased expression of VPS72 mRNA

NCBI chr 2:185,367,329...185,379,199
Ensembl chr 2:185,367,623...185,379,191

G

tryptophanyl-tRNA synthetase 1

increases expression

ISO

Antimycin A results in increased expression of WARS1 mRNA

NCBI chr 6:133,540,463...133,571,645
Ensembl chr 6:133,539,744...133,571,645

G

WD repeat domain 43

increases expression

ISO

Antimycin A results in increased expression of WDR43 mRNA

NCBI chr 6:29,565,610...29,604,954
Ensembl chr 6:29,565,610...29,604,954

G

WD repeat domain 7

decreases expression

ISO

Antimycin A results in decreased expression of WDR7 mRNA

NCBI chr18:59,435,733...59,718,800
Ensembl chr18:59,435,768...59,718,800

G

WD and tetratricopeptide repeats 1

decreases expression

ISO

Antimycin A results in decreased expression of WDTC1 mRNA

NCBI chr 5:150,775,358...150,843,558
Ensembl chr 5:150,775,358...150,824,307

G

Wnt family member 7A

increases expression

ISO

Antimycin A results in increased expression of WNT7A mRNA

NCBI chr 4:125,420,276...125,466,149
Ensembl chr 4:125,420,276...125,466,149

G

X-box binding protein 1

increases expression

EXP
ISO

Antimycin A results in increased expression of XBP1 protein
Antimycin A results in increased expression of XBP1 mRNA

PMID:21337367 PMID:33512557

NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706

G

YES proto-oncogene 1, Src family tyrosine kinase

decreases expression

ISO

Antimycin A results in decreased expression of YES1 mRNA

NCBI chr 9:120,646,657...120,753,880
Ensembl chr 9:120,646,838...120,746,441

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta

decreases expression

ISO

Antimycin A results in decreased expression of YWHAB mRNA

NCBI chr 3:173,078,904...173,101,508
Ensembl chr 3:173,079,041...173,101,854

G

zinc finger and BTB domain containing 21

increases expression

ISO

Antimycin A results in increased expression of ZBTB21 mRNA

NCBI chr11:50,781,697...50,796,399
Ensembl chr11:50,781,099...50,796,560

G

zinc finger and BTB domain containing 41

decreases expression

ISO

Antimycin A results in decreased expression of ZBTB41 mRNA

NCBI chr13:53,591,961...53,622,007
Ensembl chr13:53,592,797...53,617,780

G

zinc finger E-box binding homeobox 2

decreases expression

ISO

Antimycin A results in decreased expression of ZEB2 mRNA

NCBI chr 3:49,624,028...49,754,323
Ensembl chr 3:49,624,028...49,754,323

G

zinc finger AN1-type containing 2A

increases expression

ISO

Antimycin A results in increased expression of ZFAND2A mRNA

NCBI chr12:20,275,435...20,286,513
Ensembl chr12:20,275,450...20,286,513

G

zinc finger protein 469

increases expression

ISO

Antimycin A results in increased expression of ZNF469 mRNA

NCBI chr19:67,190,901...67,232,569
Ensembl chr19:67,190,901...67,232,569

G

zinc fingers and homeoboxes 1

decreases expression

ISO

Antimycin A results in decreased expression of ZHX1 mRNA

NCBI chr 7:91,472,193...91,501,984
Ensembl chr 7:91,473,836...91,501,115

G

zinc finger RANBP2-type containing 2

increases expression

ISO

Antimycin A results in increased expression of ZRANB2 mRNA

NCBI chr 2:249,232,010...249,245,786
Ensembl chr 2:249,232,010...249,245,780

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

increases expression

EXP

riddelliine results in increased expression of ABCB1 mRNA; riddelliine results in increased expression of ABCB1A mRNA

PMID:18047722 PMID:18047727

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

ATP binding cassette subfamily B member 9

decreases expression

EXP

riddelliine results in decreased expression of ABCB9 mRNA

NCBI chr12:38,146,659...38,192,862
Ensembl chr12:38,159,904...38,192,860

G

ATP binding cassette subfamily C member 3

increases expression

EXP

riddelliine results in increased expression of ABCC3 mRNA

PMID:18047722 PMID:18047727

NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494

G

ATP binding cassette subfamily C member 8

decreases expression

EXP

riddelliine results in decreased expression of ABCC8 mRNA

PMID:18047722 PMID:18047727

NCBI chr 1:105,734,992...105,816,272
Ensembl chr 1:105,734,992...105,815,982

G

ATP binding cassette subfamily C member 9

decreases expression

EXP

riddelliine results in decreased expression of ABCC9 mRNA

NCBI chr 4:177,262,848...177,386,837
Ensembl chr 4:177,262,848...177,386,348

G

adrenomedullin

decreases expression

EXP

riddelliine results in decreased expression of ADM mRNA

NCBI chr 1:174,164,178...174,182,372
Ensembl chr 1:174,178,773...174,182,371

G

aryl hydrocarbon receptor

increases expression

EXP

riddelliine results in increased expression of AHR mRNA

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901

G

anaphase promoting complex subunit 1

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of ANAPC1 mRNA

NCBI chr 3:136,303,350...136,383,464
Ensembl chr 3:136,303,413...136,383,464

G

AT-rich interaction domain 2

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of ARID2 mRNA

NCBI chr 7:129,326,371...129,443,813
Ensembl chr 7:129,324,137...129,443,187

G

ATPase 13A5

decreases expression

EXP

riddelliine results in decreased expression of ATP13A5 mRNA

NCBI chr11:84,881,196...85,020,597
Ensembl chr11:84,881,230...85,020,593

G

aurora kinase A

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of AURKA mRNA

NCBI chr 3:181,546,742...181,562,890
Ensembl chr 3:181,546,742...181,562,771

G

BRISC and BRCA1 A complex member 2

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of BABAM2 mRNA

NCBI chr 6:30,089,065...30,467,508
Ensembl chr 6:30,071,611...30,467,341

G

BRCA1 associated RING domain 1

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BARD1 mRNA

NCBI chr 9:80,069,960...80,144,167
Ensembl chr 9:80,069,960...80,176,873

G

BLM RecQ like helicase

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BLM mRNA

NCBI chr 1:143,819,072...143,905,300
Ensembl chr 1:143,819,090...143,905,210

G

bora, aurora kinase A activator

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BORA mRNA

NCBI chr15:82,205,467...82,243,499
Ensembl chr15:82,205,697...82,244,052

G

BRCA1, DNA repair associated

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BRCA1 mRNA

NCBI chr10:86,917,693...86,978,012
Ensembl chr10:86,917,693...86,977,763

G

BRCA2, DNA repair associated

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BRCA2 mRNA

NCBI chr12:4,895,092...4,939,340
Ensembl chr12:4,895,447...4,936,194

G

BRCA1 interacting DNA helicase 1

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BRIP1 mRNA

NCBI chr10:71,402,035...71,528,083
Ensembl chr10:71,401,151...71,575,206

G

cyclin B1

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CCNB1 mRNA

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225

G

cyclin B2

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CCNB2 mRNA

NCBI chr 8:79,968,459...79,981,717
Ensembl chr 8:79,968,465...79,981,682

G

cell division cycle 20

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC20 mRNA

NCBI chr 5:137,251,596...137,255,799
Ensembl chr 5:137,251,596...137,255,799

G

cell division cycle 23

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC23 mRNA

NCBI chr18:26,511,019...26,534,872
Ensembl chr18:26,510,355...26,532,646

G

cell division cycle 25A

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC25A mRNA

NCBI chr 8:118,742,824...118,761,190
Ensembl chr 8:118,742,426...118,761,188

G

cell division cycle 25B

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC25B mRNA

NCBI chr 3:138,860,148...138,870,287
Ensembl chr 3:138,860,130...138,870,492

G

cell division cycle 25C

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC25C mRNA

NCBI chr18:26,608,483...26,630,292
Ensembl chr18:26,609,959...26,630,292

G

cyclin-dependent kinase 1

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDK1 mRNA

NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455

G

cyclin dependent kinase 2

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDK2 mRNA

NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878

G

cyclin-dependent kinase inhibitor 1A

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of CDKN1A mRNA

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

carboxylesterase 2H

increases expression

EXP

riddelliine results in increased expression of CES2 mRNA

NCBI chr19:49,884,164...49,898,764
Ensembl chr19:49,884,164...49,898,752

G

checkpoint kinase 1

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CHEK1 mRNA

NCBI chr 8:44,609,417...44,629,867
Ensembl chr 8:44,609,417...44,629,359

G

claspin

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CLSPN mRNA

NCBI chr 5:144,134,619...144,169,531
Ensembl chr 5:144,134,632...144,169,530

G

C-X-C motif chemokine receptor 1

increases expression

EXP

riddelliine results in increased expression of CXCR1 mRNA

NCBI chr 9:83,216,040...83,220,225
Ensembl chr 9:83,215,292...83,226,872

G

cytochrome P450, family 26, subfamily a, polypeptide 1

increases expression

EXP

riddelliine results in increased expression of CYP26A1 mRNA

NCBI chr 1:244,883,822...244,887,657
Ensembl chr 1:244,883,752...244,887,657

G

cytochrome P450, subfamily 2, polypeptide 11

decreases expression

EXP

riddelliine results in decreased expression of CYP2C mRNA

PMID:18047722 PMID:18047727

NCBI chr 1:246,175,216...246,211,445
Ensembl chr 1:246,174,711...246,211,853

G

cytochrome P450, family 2, subfamily c, polypeptide 12

increases expression

EXP

riddelliine results in increased expression of CYP2C12 mRNA; riddelliine results in increased expression of CYP2C40 mRNA

PMID:18047722 PMID:18047727

NCBI chr 1:248,619,887...248,681,945
Ensembl chr 1:248,619,882...248,677,042

G

cytochrome P450, family 2, subfamily c, polypeptide 13

decreases expression

EXP

riddelliine results in decreased expression of CYP2C13 mRNA

NCBI chr 1:248,706,787...248,787,239
Ensembl chr 1:248,706,788...248,787,210

G

cytochrome P450, family 2, subfamily c, polypeptide 22

decreases expression

EXP

riddelliine results in decreased expression of CYP2C22 mRNA

NCBI chr 1:248,941,143...248,980,767
Ensembl chr 1:248,904,062...248,971,182

G

cytochrome P450, family 2, subfamily e, polypeptide 1

increases expression

EXP

riddelliine results in increased expression of CYP2E1 mRNA

PMID:18047722 PMID:18047727

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

G

cytochrome P450, family 3, subfamily a, polypeptide 18

decreases expression

EXP

riddelliine results in decreased expression of CYP3A18 mRNA

NCBI chr12:13,994,312...14,044,185
Ensembl chr12:13,994,311...14,045,788

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases expression
increases metabolic processing
multiple interactions
increases response to substance

EXP
ISO

riddelliine results in decreased expression of CYP3A2 mRNA
CYP3A4 protein results in increased metabolism of riddelliine
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of ANAPC1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of ARID2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of ATRIP mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of AURKA mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BARD1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BLM mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BORA mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BRCA1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BRCA2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BRIP1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CCNB1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CCNB2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC20 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC23 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC25A mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC25B mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC25C mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDK1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDK2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CHEK1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CLSPN mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of E2F1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of E2F5 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of E2F8 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of ESPL1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FANCA mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FANCB mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FANCC mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FANCD2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FBXO5 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of KIF11 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of KIF23 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of MDC1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of MRE11 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of MSH2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of MSH6 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of NBN mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PBRM1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PHF10 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PKMYT1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PLK1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PLK4 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of POU2F1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PPM1L mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PPP2R1B mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PPP2R2A mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PRC1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PTTG1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RAD1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RAD21 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RBBP8 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RBL1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RBL2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC3 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC4 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC5 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RPA1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of SMARCC1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of SMC3 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of STAG2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of TLK1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of TOP2A mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of TOPBP1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of WEE1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of BABAM2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of CDKN1A mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of GADD45A mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of PLK2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of PLK3 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of PPP2CB mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of SMARCA2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of STAT1 mRNA
CYP3A4 protein results in increased susceptibility to riddelliine

PMID:18047727 PMID:32910235 PMID:33884520

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

cytochrome P450, family 3, subfamily a, polypeptide 9

increases expression

EXP

riddelliine results in increased expression of CYP3A9 mRNA

NCBI chr12:21,919,955...21,960,160
Ensembl chr12:21,919,940...21,960,154

G

cytochrome P450, family 4, subfamily a, polypeptide 8

decreases expression

EXP

riddelliine results in decreased expression of CYP4A8 mRNA

NCBI chr 5:133,938,882...133,970,226
Ensembl chr 5:133,938,883...133,970,226

G

E2F transcription factor 1

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of E2F1 mRNA

NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:163,524,739...163,535,563

G

E2F transcription factor 5

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of E2F5 mRNA

NCBI chr 2:88,718,567...88,734,143
Ensembl chr 2:88,718,567...88,734,143

G

E2F transcription factor 8

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of E2F8 mRNA

NCBI chr 1:107,701,985...107,720,538
Ensembl chr 1:107,701,985...107,720,009

G

early growth response 1

increases expression

EXP

riddelliine results in increased expression of EGR1 mRNA

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843

G

ectonucleotide pyrophosphatase/phosphodiesterase 2

decreases expression

EXP

riddelliine results in decreased expression of ENPP2 mRNA

NCBI chr 7:88,092,140...88,214,758
Ensembl chr 7:88,092,140...88,214,957

G

extra spindle pole bodies like 1, separase

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of ESPL1 mRNA

NCBI chr 7:135,302,460...135,329,570
Ensembl chr 7:135,302,716...135,329,570

G

F11 receptor

decreases expression

EXP

riddelliine results in decreased expression of F11R mRNA

NCBI chr13:86,406,229...86,429,819
Ensembl chr13:86,406,218...86,429,816

G

coagulation factor III, tissue factor

decreases expression

EXP

riddelliine results in decreased expression of F3 mRNA

NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:212,511,680...212,523,369

G

coagulation factor VII

increases expression

EXP

riddelliine results in increased expression of F7 mRNA

NCBI chr16:83,191,896...83,202,775
Ensembl chr16:83,191,914...83,202,738

G

FA complementation group A

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FANCA mRNA

NCBI chr19:68,210,562...68,271,080
Ensembl chr19:68,212,643...68,271,019

G

FA complementation group B

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FANCB mRNA

NCBI chr X:33,035,387...33,051,993
Ensembl chr X:33,035,387...33,051,808

G

FA complementation group C

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FANCC mRNA

NCBI chr17:1,686,374...1,818,672
Ensembl chr17:1,687,017...1,835,096

G

FA complementation group D2

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FANCD2 mRNA

NCBI chr 4:148,234,633...148,299,035
Ensembl chr 4:148,234,708...148,299,035

G

Fas cell surface death receptor

increases expression

EXP

riddelliine results in increased expression of FAS mRNA

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104

G

F-box protein 5

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FBXO5 mRNA

NCBI chr 1:44,601,412...44,607,781
Ensembl chr 1:44,601,412...44,607,781

G

flavin containing dimethylaniline monoxygenase 5

increases expression

EXP

riddelliine results in increased expression of FMO5 mRNA

NCBI chr 2:187,885,741...187,938,468
Ensembl chr 2:187,910,964...187,938,464

G

growth arrest and DNA-damage-inducible, alpha

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of GADD45A mRNA

NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:97,484,502...97,486,807

G

glutathione S-transferase alpha 3

increases expression

EXP

riddelliine results in increased expression of GSTA3 mRNA

PMID:18047722 PMID:18047727

NCBI chr 9:31,154,989...31,180,653
Ensembl chr 9:31,154,989...31,180,654

G

glutathione S-transferase mu 1

decreases expression

EXP

riddelliine results in decreased expression of GSTM1 mRNA

NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:198,338,008...198,343,569

G

glutathione S-transferase mu 2

decreases expression

EXP

riddelliine results in decreased expression of GSTM2 mRNA

NCBI chr 2:198,312,179...198,316,962

G

H2A.X variant histone

increases phosphorylation
increases expression

EXP
ISO

riddelliine results in increased phosphorylation of H2AX protein
riddelliine results in increased expression of H2AX protein

PMID:31154085 PMID:31289892

NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079

G

hepatocyte growth factor

increases expression

EXP

riddelliine results in increased expression of HGF mRNA

NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:19,632,267...19,700,851

G

insulin-like growth factor binding protein 1

increases expression

EXP

riddelliine results in increased expression of IGFBP1 mRNA

NCBI chr14:86,261,277...86,266,344
Ensembl chr14:86,261,277...86,266,344

G

insulin-like growth factor binding protein 2

increases expression

EXP

riddelliine results in increased expression of IGFBP2 mRNA

NCBI chr 9:81,864,811...81,892,179
Ensembl chr 9:81,864,783...81,892,171

G

interleukin 11

increases expression

EXP

riddelliine results in increased expression of IL11 mRNA

NCBI chr 1:78,098,622...78,104,915
Ensembl chr 1:78,096,930...78,104,915

G

interleukin 15

increases expression

EXP

riddelliine results in increased expression of IL15 mRNA

NCBI chr19:42,536,160...42,611,349
Ensembl chr19:42,545,346...42,611,348

G

interleukin 7

decreases expression

EXP

riddelliine results in decreased expression of IL7 mRNA

NCBI chr 2:96,142,523...96,186,282
Ensembl chr 2:96,142,092...96,187,389

G

indolethylamine N-methyltransferase

decreases expression

EXP

riddelliine results in decreased expression of INMT mRNA

NCBI chr 4:85,648,459...85,652,755
Ensembl chr 4:85,648,459...85,652,755

G

integrin subunit alpha 4

increases expression

EXP

riddelliine results in increased expression of ITGA4 mRNA

NCBI chr 3:84,569,487...84,646,276
Ensembl chr 3:84,560,369...84,641,039

G

integrin subunit alpha 6

decreases expression

EXP

riddelliine results in decreased expression of ITGA6 mRNA

NCBI chr 3:77,012,168...77,097,076
Ensembl chr 3:77,017,766...77,097,076

G

kinase insert domain receptor

multiple interactions
increases expression

EXP

riddelliine results in increased phosphorylation of and results in increased activity of KDR protein
riddelliine results in increased expression of KDR protein

PMID:12460743 PMID:15384251

NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,572,049...32,615,192

G

kinesin family member 11

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of KIF11 mRNA

NCBI chr 1:244,494,916...244,589,250
Ensembl chr 1:244,494,875...244,589,250

G

kinesin family member 23

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of KIF23 mRNA

NCBI chr 8:71,293,439...71,321,911
Ensembl chr 8:71,293,482...71,320,856

G

KRAS proto-oncogene, GTPase

increases mutagenesis

ISO

riddelliine results in increased mutagenesis of KRAS gene

PMID:13678655 PMID:20737008

NCBI chr 4:179,916,255...179,949,613
Ensembl chr 4:179,919,802...179,949,320

G

leptin receptor

increases expression

EXP

riddelliine results in increased expression of LEPR mRNA

NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:121,474,099...121,591,215

G

mediator of DNA damage checkpoint 1

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of MDC1 mRNA

NCBI chr20:2,898,496...2,914,960
Ensembl chr20:2,900,308...2,914,960

G

matrix metallopeptidase 7

decreases expression

EXP

riddelliine results in decreased expression of MMP7 mRNA

NCBI chr 8:13,133,043...13,140,761
Ensembl chr 8:13,133,043...13,140,755

G

MRE11 homolog, double strand break repair nuclease

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of MRE11 mRNA

NCBI chr 8:19,900,211...19,961,906
Ensembl chr 8:19,913,772...19,961,904

G

mutS homolog 2

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of MSH2 mRNA

NCBI chr 6:12,567,368...12,626,534
Ensembl chr 6:12,567,368...12,626,503

G

mutS homolog 6

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of MSH6 mRNA

NCBI chr 6:12,316,190...12,333,505
Ensembl chr 6:12,316,198...12,333,844

G

metallothionein 1A

increases expression

EXP

riddelliine results in increased expression of MT1A mRNA

NCBI chr19:10,831,959...10,832,975
Ensembl chr17:79,695,809...79,696,200
Ensembl chr X:79,695,809...79,696,200
Ensembl chr19:79,695,809...79,696,200

G

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase

decreases expression

EXP

riddelliine results in decreased expression of MTHFD2 mRNA

NCBI chr 4:117,368,833...117,380,350
Ensembl chr 4:117,368,835...117,380,350

G

nibrin

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of NBN mRNA

NCBI chr 5:34,256,678...34,291,163
Ensembl chr 5:34,256,627...34,291,162

G

NAD(P)H quinone dehydrogenase 1

increases expression

EXP

riddelliine results in increased expression of NQO1 mRNA

PMID:18047722 PMID:18047727

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

polybromo 1

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PBRM1 mRNA

NCBI chr16:6,219,933...6,319,336
Ensembl chr16:6,219,917...6,319,336

G

PHD finger protein 10

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PHF10 mRNA

NCBI chr 1:64,625,373...64,642,110
Ensembl chr 1:64,624,465...64,642,049

G

protein kinase, membrane associated tyrosine/threonine 1

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PKMYT1 mRNA

NCBI chr10:13,252,805...13,263,584
Ensembl chr10:13,252,816...13,264,263

G

polo-like kinase 1

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PLK1 mRNA

NCBI chr 1:186,147,658...186,157,637
Ensembl chr 1:186,147,658...186,157,637

G

polo-like kinase 2

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of PLK2 mRNA

NCBI chr 2:43,702,536...43,708,305
Ensembl chr 2:43,701,865...43,708,296

G

polo-like kinase 3

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of PLK3 mRNA

NCBI chr 5:135,843,725...135,848,900
Ensembl chr 5:135,843,725...135,848,900

G

polo-like kinase 4

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PLK4 mRNA

NCBI chr 2:125,730,480...125,748,894
Ensembl chr 2:125,730,460...125,748,892

G

POU class 2 homeobox 1

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of POU2F1 mRNA

NCBI chr13:80,653,602...80,796,279
Ensembl chr13:80,663,714...80,796,356

G

peroxisome proliferator-activated receptor gamma

decreases expression

EXP

riddelliine results in decreased expression of PPARG mRNA

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

protein phosphatase, Mg2+/Mn2+ dependent, 1L

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PPM1L mRNA

NCBI chr 2:155,876,605...156,149,371
Ensembl chr 2:155,876,605...156,149,371

G

protein phosphatase 2 catalytic subunit beta

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of PPP2CB mRNA

NCBI chr16:65,261,178...65,282,658
Ensembl chr16:65,261,181...65,282,634

G

protein phosphatase 2 scaffold subunit A beta

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PPP2R1B mRNA

NCBI chr 8:60,092,540...60,125,512
Ensembl chr 8:60,081,553...60,125,795

G

protein phosphatase 2, regulatory subunit B, alpha

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PPP2R2A mRNA

NCBI chr15:45,380,142...45,439,428
Ensembl chr15:45,379,683...45,439,405

G

protein regulator of cytokinesis 1

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PRC1 mRNA

NCBI chr 1:143,659,312...143,681,019
Ensembl chr 1:143,659,481...143,681,012

G

protein kinase C, alpha

increases expression

EXP

riddelliine results in increased expression of PRKCA mRNA

NCBI chr10:93,388,991...93,787,617
Ensembl chr10:93,388,991...93,787,572

G

protein kinase C, zeta

increases expression

EXP

riddelliine results in increased expression of PRKCZ mRNA

NCBI chr 5:171,101,774...171,212,694
Ensembl chr 5:171,101,774...171,212,674

G

PTTG1 regulator of sister chromatid separation, securin

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PTTG1 mRNA

NCBI chr10:28,394,940...28,406,410
Ensembl chr10:28,394,814...28,406,309

G

RAD1 checkpoint DNA exonuclease

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RAD1 mRNA

NCBI chr 2:61,188,755...61,196,868
Ensembl chr 2:61,188,727...61,196,867

G

RAD21 cohesin complex component

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RAD21 mRNA

NCBI chr 7:85,177,715...85,204,657
Ensembl chr 7:85,177,716...85,204,657

G

RB binding protein 8, endonuclease

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RBBP8 mRNA

NCBI chr18:3,198,188...3,263,643
Ensembl chr18:3,197,310...3,263,985

G

RB transcriptional corepressor like 1

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RBL1 mRNA

NCBI chr 3:166,226,187...166,289,862
Ensembl chr 3:166,226,198...166,289,376

G

RB transcriptional corepressor like 2

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RBL2 mRNA

NCBI chr19:32,049,690...32,096,467
Ensembl chr19:32,049,691...32,096,411

G

renin

increases expression

EXP

riddelliine results in increased expression of REN mRNA

NCBI chr13:47,348,312...47,359,539
Ensembl chr13:47,348,143...47,359,543

G

replication factor C subunit 1

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC1 mRNA

NCBI chr14:43,319,768...43,395,028
Ensembl chr14:43,319,935...43,395,026

G

replication factor C subunit 2

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC2 mRNA

NCBI chr12:27,756,920...27,770,049
Ensembl chr12:27,756,922...27,770,025

G

replication factor C subunit 3

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC3 mRNA

NCBI chr12:5,836,546...5,847,331
Ensembl chr12:5,836,553...5,847,340

G

replication factor C subunit 4

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC4 mRNA

NCBI chr11:91,254,273...91,268,727
Ensembl chr11:91,254,243...91,268,730

G

replication factor C subunit 5

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC5 mRNA

NCBI chr12:44,868,322...44,877,879
Ensembl chr12:44,862,329...44,878,151

G

replication protein A1

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RPA1 mRNA

NCBI chr10:60,647,185...60,698,279
Ensembl chr10:60,647,185...60,698,279

G

sphingosine-1-phosphate receptor 2

decreases expression

EXP

riddelliine results in decreased expression of S1PR2 mRNA

NCBI chr 8:27,779,452...27,790,344
Ensembl chr 8:27,774,566...27,790,577

G

solute carrier family 13 member 5

decreases expression

EXP

riddelliine results in decreased expression of SLC13A5 mRNA

NCBI chr10:57,364,806...57,389,500
Ensembl chr10:57,364,806...57,389,516

G

solute carrier family 16, member 4

decreases expression

EXP

riddelliine results in decreased expression of SLC16A4 mRNA

NCBI chr 2:197,593,738...197,621,569
Ensembl chr 2:197,599,295...197,621,562

G

solute carrier family 22 member 6

decreases expression

EXP

riddelliine results in decreased expression of SLC22A6 mRNA

NCBI chr 1:214,951,493...214,960,317
Ensembl chr 1:214,951,867...214,960,311

G

solute carrier family 22 member 8

decreases expression

EXP

riddelliine results in decreased expression of SLC22A8 mRNA

NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:214,925,508...214,946,588

G

solute carrier family 25 member 21

increases expression

EXP

riddelliine results in increased expression of SLC25A21 mRNA

NCBI chr 6:79,938,480...80,437,937
Ensembl chr 6:79,938,480...80,437,502

G

solute carrier family 25, member 30

decreases expression

EXP

riddelliine results in decreased expression of SLC25A30 mRNA

NCBI chr15:57,486,346...57,508,981
Ensembl chr15:57,486,350...57,502,690

G

solute carrier family 7 member 5

increases expression

EXP

riddelliine results in increased expression of SLC7A5 mRNA

NCBI chr19:66,843,808...66,872,412
Ensembl chr19:66,843,808...66,872,412

G

SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of SMARCA2 mRNA

NCBI chr 1:233,617,277...233,784,908
Ensembl chr 1:233,617,366...233,784,869

G

SWI/SNF related BAF chromatin remodeling complex subunit C1

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of SMARCC1 mRNA

NCBI chr 8:118,986,917...119,093,161
Ensembl chr 8:118,989,516...119,093,152

G

structural maintenance of chromosomes 3

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of SMC3 mRNA

NCBI chr 1:262,606,731...262,649,832
Ensembl chr 1:262,607,080...262,649,825

G

SRC proto-oncogene, non-receptor tyrosine kinase

increases expression

EXP

riddelliine results in increased expression of SRC mRNA

NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462

G

STAG2 cohesin complex component

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of STAG2 mRNA

NCBI chr X:125,839,660...125,971,209
Ensembl chr X:125,840,401...125,971,209

G

signal transducer and activator of transcription 1

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of STAT1 mRNA

NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:56,911,523...57,077,346

G

sulfotransferase family 1C member 3

decreases expression

EXP

riddelliine results in decreased expression of SULT1C1 mRNA

NCBI chr 9:7,548,839...7,594,299
Ensembl chr 9:7,548,622...7,594,295

G

transforming growth factor alpha

decreases expression

EXP

riddelliine results in decreased expression of TGFA mRNA

NCBI chr 4:120,175,549...120,258,342
Ensembl chr 4:120,175,593...120,258,339

G

tousled-like kinase 1

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of TLK1 mRNA

NCBI chr 3:75,928,303...76,035,246
Ensembl chr 3:75,928,303...76,035,059

G

tumor necrosis factor

decreases expression

EXP

riddelliine results in decreased expression of TNF mRNA

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF superfamily member 10

increases expression

EXP

riddelliine results in increased expression of TNFSF10 mRNA

NCBI chr 2:112,136,550...112,155,903

G

DNA topoisomerase II alpha

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of TOP2A mRNA

NCBI chr10:84,441,954...84,473,093
Ensembl chr10:84,441,954...84,473,366

G

DNA topoisomerase II binding protein 1

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of TOPBP1 mRNA

NCBI chr 8:112,766,791...112,815,203
Ensembl chr 8:112,766,508...112,810,540

G

tumor protein p53

increases expression
increases mutagenesis

EXP
ISO

riddelliine results in increased expression of TP53 protein
riddelliine results in increased mutagenesis of TRP53 gene

PMID:12460743 PMID:13678655 PMID:20737008

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

WEE1 G2 checkpoint kinase

multiple interactions

ISO

[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of WEE1 mRNA

NCBI chr 1:173,605,609...173,632,450
Ensembl chr 1:173,608,949...173,632,449

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

eukaryotic translation elongation factor 1 alpha 1

multiple interactions

ISO

swinholide A affects the reaction [EEF1A1 protein binds to SPP1 5' UTR]

NCBI chr 8:88,221,839...88,225,688
Ensembl chr 8:88,221,843...88,225,072

G

secreted phosphoprotein 1

multiple interactions
increases expression

ISO

swinholide A affects the reaction [EEF1A1 protein binds to SPP1 5' UTR]
swinholide A results in increased expression of SPP1 protein

NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

interleukin 2

increases expression
affects secretion

ISO

muconomycin A results in increased expression of IL2 mRNA
muconomycin A affects the secretion of IL2 protein

NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672

G

interleukin 4

affects secretion
increases expression

ISO

muconomycin A affects the secretion of IL4 protein
muconomycin A results in increased expression of IL4 mRNA

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549

G

interleukin 5

affects secretion

ISO

muconomycin A affects the secretion of IL5 protein

NCBI chr10:38,375,132...38,378,003
Ensembl chr10:38,375,132...38,378,003

G

interleukin 6

increases expression

ISO

muconomycin A results in increased expression of IL6 mRNA

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	20862
chemical entity	20860
atom	20860
nonmetal atom	20766
oxygen atom	20457
oxygen molecular entity	20457
organooxygen compound	19806
polyketide	11596
macrolide	7579
macropolylide	760
macrodiolide +	757
macrotetrolide +	0
macrotriolide +	4
Path 2
Term	Annotations
CHEBI ontology	20862
subatomic particle	20860
composite particle	20860
hadron	20860
baryon	20860
nucleon	20860
atomic nucleus	20860
atom	20860
main group element atom	20781
p-block element atom	20781
carbon group element atom	20715
carbon atom	20710
organic molecular entity	20710
heteroorganic entity	20219
organochalcogen compound	19904
organooxygen compound	19806
ester	17805
carboxylic ester	17260
lactone	13419
macrocyclic lactone	7630
macrolide	7579
macropolylide	760
macrodiolide +	757
macrotetrolide +	0
macrotriolide +	4

paths to the root