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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ravuconazole
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Accession:CHEBI:143825 term browser browse the term
Definition:A member of the class of triazoles that is 1-butyl-1H-1,2,4-triazole in which the butyl group is substituted at positions 2, 2, and 3 by hydroxy, 2,4-difluorophenyl, and 4-(p-cyanophenyl)-1,3-thiazol-2-yl groups, respectively (the R,R stereoisomer). It exhibits antifungal activity by inhibition of 14alpha demethylase, an enzyme involved in sterol synthesis, resulting in lysis of the fungal cell wall and fungal cell death. (NCIO4)
Synonyms:exact_synonym: 4-[2-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)butan-2-yl]-1,3-thiazol-4-yl]benzonitrile
 related_synonym: BMS 207147;   BMS-20714;   ER-30346;   Formula=C22H17F2N5OS;   InChI=1S/C22H17F2N5OS/c1-14(21-28-20(10-31-21)16-4-2-15(9-25)3-5-16)22(30,11-29-13-26-12-27-29)18-7-6-17(23)8-19(18)24/h2-8,10,12-14,30H,11H2,1H3/t14-,22+/m0/s1;   InChIKey=OPAHEYNNJWPQPX-RCDICMHDSA-N;   SMILES=C=1C(=C(C=C(C1)F)F)[C@@]([C@@H](C)C2=NC(=CS2)C=3C=CC(=CC3)C#N)(O)CN4C=NC=N4;   ravuconazol;   ravuconazolum
 xref: CAS:182760-06-1;   DrugBank:DB06440;   HMDB:HMDB0257114;   KEGG:D02556;   PMCID:PMC105592;   PMID:10566016;   PMID:11709320;   PMID:18548464;   PMID:20112166;   PMID:20404124;   PMID:22652223;   PMID:22935068;   PMID:24071640;   PMID:24945848;   PMID:25742996;   PMID:27904057;   PMID:28553114;   PMID:29768713;   PMID:29982734;   PMID:30733479;   PMID:31769120;   PMID:31773164;   PMID:31875604;   PMID:32115444;   PMID:32423960;   PMID:32571811;   PMID:33609301;   PMID:34075394;   PMID:34375652;   PMID:35120131;   PMID:35398930;   PMID:8891121;   PMID:9527778;   Patent:US2011087030;   Patent:WO2011042827;   Wikipedia:Ravuconazole


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Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    chemical entity 19878
      group 19831
        pseudohalo group 4581
          cyano group 4581
            nitrile 4581
              ravuconazole 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            organic molecule 19706
                              organic cyclic compound 19495
                                organic heterocyclic compound 18874
                                  heteroarene 17155
                                    monocyclic heteroarene 14983
                                      azole 14506
                                        thiazoles 1800
                                          1,3-thiazoles 1231
                                            ravuconazole 0
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