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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:rubimaillin
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Accession:CHEBI:141063 term browser browse the term
Definition:A benzochromene that is 2H-benzo[h]chromene which is substituted by two methyl groups at position 2, a methoxycarbonyl group at position 5, and a hydroxy group at position 6. Found in the Chinese medical plant Rubia cordifola, It has an anti-cancer effect by inhibition of TNF-alpha-induced NF-kappaB activation. It is also a dual inhibitor of acyl-CoA:cholesterol acyltransferase 1 and 2 (ACAT1 and ACAT2), but is more selective for the ACAT2 isozyme.
Synonyms:exact_synonym: methyl 6-hydroxy-2,2-dimethyl-2H-benzo[h]chromene-5-carboxylate
 related_synonym: Formula=C17H16O4;   InChI=1S/C17H16O4/c1-17(2)9-8-12-13(16(19)20-3)14(18)10-6-4-5-7-11(10)15(12)21-17/h4-9,18H,1-3H3;   InChIKey=VLGATXOTCNBWIT-UHFFFAOYSA-N;   SMILES=C12=CC=CC=C1C3=C(C(=C2O)C(OC)=O)C=CC(O3)(C)C;   mollugin
 xref: CAS:55481-88-4
 xref_mesh: MESH:C046245
 xref: PMID:19652367;   PMID:19716835;   PMID:19765578;   PMID:21077262;   PMID:21236252;   PMID:22997839;   PMID:23000442;   PMID:23065756;   PMID:23318249;   PMID:23466342;   PMID:23738323;   PMID:23845549;   PMID:24887566;   PMID:25310176;   PMID:25636867;   PMID:26126771;   PMID:26681510;   PMID:26697688;   PMID:27258244;   PMID:28933726;   PMID:29027119


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rubimaillin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression
multiple interactions 		ISO rubimaillin results in decreased expression of ABCB1 mRNA; rubimaillin results in decreased expression of ABCB1 protein
dorsomorphin inhibits the reaction [rubimaillin results in decreased expression of ABCB1 mRNA]; rubimaillin inhibits the reaction [RELA protein results in increased expression of ABCB1 protein] 		CTD PMID:23466342 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135 		JBrowse link
G Acaca acetyl-CoA carboxylase alpha increases phosphorylation ISO rubimaillin results in increased phosphorylation of ACACA protein CTD PMID:23466342 NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,511,857...69,773,888 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions 		ISO rubimaillin results in decreased phosphorylation of AKT1 protein
dorsomorphin inhibits the reaction [rubimaillin results in decreased phosphorylation of AKT1 protein] 		CTD PMID:23466342 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP12 protein]; BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP3 protein]; BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP7 protein]; BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP8 protein]; BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP9 protein]; BCL2L1 protein inhibits the reaction [rubimaillin results in increased cleavage of BID protein]; BCL2L1 protein inhibits the reaction [rubimaillin results in increased cleavage of CFLAR protein]; BCL2L1 protein inhibits the reaction [rubimaillin results in increased degradation of PARP1 protein] CTD PMID:19716835 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907 		JBrowse link
G Bid BH3 interacting domain death agonist increases cleavage
multiple interactions 		ISO rubimaillin results in increased cleavage of BID protein
BCL2L1 protein inhibits the reaction [rubimaillin results in increased cleavage of BID protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [rubimaillin results in increased cleavage of BID protein] 		CTD PMID:19716835 NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:155,785,377...155,808,275 		JBrowse link
G Casp12 caspase 12 increases activity
multiple interactions 		ISO rubimaillin results in increased activity of CASP12 protein
BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP12 protein] 		CTD PMID:19716835 NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:10,926,994...10,954,442 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions 		ISO rubimaillin results in increased activity of CASP3 protein
BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP3 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone affects the reaction [rubimaillin results in increased activity of CASP3 protein] 		CTD PMID:19716835 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions 		ISO rubimaillin results in increased activity of CASP7 protein
BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP7 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [rubimaillin results in increased activity of CASP7 protein] 		CTD PMID:19716835 NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512 		JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions 		ISO rubimaillin results in increased activity of CASP8 protein
BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP8 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [rubimaillin results in increased activity of CASP8 protein] 		CTD PMID:19716835 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions 		ISO rubimaillin results in increased activity of CASP9 protein
BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP9 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone affects the reaction [rubimaillin results in increased activity of CASP9 protein] 		CTD PMID:19716835 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Ccna2 cyclin A2 multiple interactions
decreases expression 		ISO Glutathione inhibits the reaction [rubimaillin results in decreased expression of CCNA2 protein] CTD PMID:35007525 NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:121,355,363...121,361,701 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression
multiple interactions 		ISO rubimaillin results in decreased expression of CDK2 protein
Glutathione inhibits the reaction [rubimaillin results in decreased expression of CDK2 protein] 		CTD PMID:35007525 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator increases cleavage
multiple interactions 		ISO rubimaillin results in increased cleavage of CFLAR protein
BCL2L1 protein inhibits the reaction [rubimaillin results in increased cleavage of CFLAR protein] 		CTD PMID:19716835 NCBI chr 9:67,679,502...67,747,226
Ensembl chr 9:67,679,559...67,726,434 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases expression
decreases phosphorylation 		ISO rubimaillin results in decreased expression of CREB1 mRNA
rubimaillin results in decreased phosphorylation of CREB1 protein 		CTD PMID:23466342 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation ISO rubimaillin results in increased phosphorylation of GSK3B protein CTD PMID:23466342 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249 		JBrowse link
G H2ax H2A.X variant histone increases phosphorylation
multiple interactions 		ISO rubimaillin results in increased phosphorylation of H2AX protein
Glutathione inhibits the reaction [rubimaillin results in increased phosphorylation of H2AX protein] 		CTD PMID:35007525 NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079 		JBrowse link
G Nfkbia NFKB inhibitor alpha increases phosphorylation ISO rubimaillin results in increased phosphorylation of NFKBIA protein CTD PMID:23466342 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases degradation
multiple interactions 		ISO rubimaillin results in increased degradation of PARP1 protein
BCL2L1 protein inhibits the reaction [rubimaillin results in increased degradation of PARP1 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [rubimaillin results in increased degradation of PARP1 protein] 		CTD PMID:19716835 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO rubimaillin results in decreased expression of PTGS2 mRNA; rubimaillin results in decreased expression of PTGS2 protein CTD PMID:23466342 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases expression 		ISO rubimaillin inhibits the reaction [RELA protein results in increased expression of ABCB1 protein]
rubimaillin results in decreased expression of RELA protein 		CTD PMID:23466342 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Stk11 serine/threonine kinase 11 increases phosphorylation ISO rubimaillin results in increased phosphorylation of STK11 protein CTD PMID:23466342 NCBI chr 7:10,225,204...10,241,965
Ensembl chr 7:10,225,204...10,241,965 		JBrowse link
Term paths to the root
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  CHEBI ontology 20873
    role 20805
      application 20634
        anti-inflammatory agent 16827
          rubimaillin 21
Path 2
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  CHEBI ontology 20873
    subatomic particle 20871
      composite particle 20871
        hadron 20871
          baryon 20871
            nucleon 20871
              atomic nucleus 20871
                atom 20871
                  main group element atom 20794
                    p-block element atom 20794
                      chalcogen 20505
                        oxygen atom 20472
                          oxygen molecular entity 20472
                            hydroxides 20244
                              organic hydroxy compound 19780
                                alcohol 16146
                                  aliphatic alcohol 12645
                                    alkyl alcohol 12567
                                      methanol 4014
                                        methyl ester 3961
                                          rubimaillin 21
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