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G |
Aldh1a1 |
aldehyde dehydrogenase 1 family, member A1 |
multiple interactions increases oxidation |
ISO |
[ALDH1A1 protein results in increased oxidation of 4-nitrophenyl acetate] results in increased chemical synthesis of [4-nitrophenol co-treated with Acetic Acid] |
CTD |
PMID:25450233 |
|
NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
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G |
Aldh2 |
aldehyde dehydrogenase 2 family member |
multiple interactions increases hydrolysis |
ISO |
daidzin inhibits the reaction [ALDH2 protein results in increased hydrolysis of 4-nitrophenyl acetate] |
CTD |
PMID:21349255 |
|
NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521
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G |
Aldh3a1 |
aldehyde dehydrogenase 3 family, member A1 |
increases hydrolysis |
ISO |
ALDH3A1 protein results in increased hydrolysis of 4-nitrophenyl acetate |
CTD |
PMID:21349255 |
|
NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681
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G |
Aldh3b1 |
aldehyde dehydrogenase 3 family, member B1 |
affects binding |
ISO |
4-nitrophenyl acetate binds to ALDH3B1 protein |
CTD |
PMID:20699116 |
|
NCBI chr 1:201,145,309...201,162,675
Ensembl chr 1:201,145,309...201,163,921
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G |
Car2 |
carbonic anhydrase 2 |
increases metabolic processing |
ISO |
CA2 protein results in increased metabolism of 4-nitrophenyl acetate |
CTD |
PMID:16858005 |
|
NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
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G |
Cel |
carboxyl ester lipase |
affects metabolic processing |
ISO |
CEL protein affects the metabolism of 4-nitrophenyl acetate |
CTD |
PMID:11592731 |
|
NCBI chr 3:11,883,532...11,891,035
Ensembl chr 3:11,883,532...11,891,035
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G |
Ces1d |
carboxylesterase 1D |
multiple interactions increases hydrolysis decreases metabolic processing increases metabolic processing |
ISO |
[CES1 protein results in increased hydrolysis of 4-nitrophenyl acetate] which results in increased chemical synthesis of 4-nitrophenol; Aripiprazole inhibits the reaction [CES1 protein results in increased hydrolysis of 4-nitrophenyl acetate]; CES1 protein binds to and results in increased hydrolysis of 4-nitrophenyl acetate; Fluoxetine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-nitrophenyl acetate]; Perphenazine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-nitrophenyl acetate]; Thioridazine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-nitrophenyl acetate] CES1 gene mutant form results in decreased metabolism of 4-nitrophenyl acetate CES1 protein results in increased metabolism of 4-nitrophenyl acetate |
CTD |
PMID:10518925 PMID:16282638 PMID:18485328 PMID:20097249 |
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NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
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G |
Ces2e |
carboxylesterase 2E |
affects metabolic processing |
ISO |
CES2E protein affects the metabolism of 4-nitrophenyl acetate |
CTD |
PMID:15123619 |
|
NCBI chr19:157,447...172,822
Ensembl chr19:157,407...172,856
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G |
Ces3a |
carboxylesterase 3a |
increases hydrolysis |
ISO |
CES3 protein results in increased hydrolysis of 4-nitrophenyl acetate |
CTD |
PMID:10518925 |
|
NCBI chr19:32,992,386...33,000,562
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G |
Pon1 |
paraoxonase 1 |
increases hydrolysis |
ISO |
PON1 protein results in increased hydrolysis of 4-nitrophenyl acetate |
CTD |
PMID:21382471 |
|
NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
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G |
Abca1 |
ATP binding cassette subfamily A member 1 |
decreases expression multiple interactions affects expression increases expression |
ISO |
Aspirin results in decreased expression of ABCA1 mRNA Aspirin affects the expression of and affects the activity of ABCA1 protein; PPARA affects the reaction [Aspirin affects the expression of ABCA1 mRNA]; PPARA affects the reaction [Aspirin affects the expression of ABCA1 protein] Aspirin results in increased expression of ABCA1 mRNA; Aspirin results in increased expression of ABCA1 protein |
CTD |
PMID:15037193 PMID:20137092 PMID:21088444 |
|
NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
increases expression multiple interactions increases activity |
ISO EXP |
Aspirin results in increased expression of ABCB1 mRNA; Aspirin results in increased expression of ABCB1 protein [Aspirin results in increased expression of ABCB1 protein] which results in decreased uptake of clopidogrel Aspirin results in increased activity of ABCB1 protein |
CTD |
PMID:19840843 PMID:21900887 |
|
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcb1b |
ATP-binding cassette, sub-family B member 1B |
increases activity |
EXP |
Aspirin results in increased activity of ABCB1B protein |
CTD |
PMID:19840843 |
|
NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
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G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
increases expression |
ISO |
Aspirin results in increased expression of ABCC1 mRNA; Aspirin results in increased expression of ABCC1 protein |
CTD |
PMID:21900887 |
|
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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G |
Abcc4 |
ATP binding cassette subfamily C member 4 |
increases expression |
ISO |
Aspirin results in increased expression of ABCC4 mRNA; Aspirin results in increased expression of ABCC4 protein |
CTD |
PMID:21900887 |
|
NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
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G |
Abcc5 |
ATP binding cassette subfamily C member 5 |
increases expression |
ISO |
Aspirin results in increased expression of ABCC5 mRNA; Aspirin results in increased expression of ABCC5 protein |
CTD |
PMID:21900887 |
|
NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253
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G |
Acaca |
acetyl-CoA carboxylase alpha |
increases expression multiple interactions |
ISO |
Aspirin results in increased expression of ACACA protein modified form CES1 protein promotes the reaction [Aspirin results in increased expression of ACACA protein modified form] |
CTD |
PMID:25743752 |
|
NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
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G |
Acadm |
acyl-CoA dehydrogenase medium chain |
increases expression |
ISO |
Aspirin results in increased expression of ACADM mRNA; Aspirin results in increased expression of ACADM protein |
CTD |
PMID:25743752 |
|
NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147
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G |
Acap3 |
ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 |
increases expression |
ISO |
Aspirin results in increased expression of ACAP3 mRNA |
CTD |
PMID:11906190 |
|
NCBI chr 5:166,501,150...166,515,477
Ensembl chr 5:166,500,781...166,515,481
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G |
Ace |
angiotensin I converting enzyme |
affects response to substance |
ISO |
ACE polymorphism affects the susceptibility to Aspirin |
CTD |
PMID:18727619 |
|
NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
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G |
Acin1 |
apoptotic chromatin condensation inducer 1 |
decreases expression increases expression |
ISO |
Aspirin results in decreased expression of ACIN1 mRNA Aspirin results in increased expression of ACIN1 mRNA |
CTD |
PMID:11906190 PMID:15928584 |
|
NCBI chr15:28,102,112...28,147,001
Ensembl chr15:28,102,112...28,147,001
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G |
Actb |
actin, beta |
multiple interactions |
ISO |
Aspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of ACTB protein] |
CTD |
PMID:17303692 |
|
NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877
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G |
Actr3 |
actin related protein 3 |
decreases expression |
ISO |
Aspirin results in decreased expression of ACTR3 mRNA |
CTD |
PMID:11906190 |
|
NCBI chr13:36,800,739...36,843,837
Ensembl chr13:36,800,093...36,844,124
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G |
Adam33 |
ADAM metallopeptidase domain 33 |
affects response to substance |
ISO |
ADAM33 SNP affects the susceptibility to Aspirin |
CTD |
PMID:17061022 |
|
NCBI chr 3:118,262,395...118,283,456
Ensembl chr 3:118,271,029...118,283,461
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G |
Adamts1 |
ADAM metallopeptidase with thrombospondin type 1 motif, 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of ADAMTS1 mRNA |
CTD |
PMID:15456535 |
|
NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103
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G |
Adk |
adenosine kinase |
affects binding |
EXP |
Aspirin binds to ADK protein |
CTD |
PMID:15236443 |
|
NCBI chr15:2,863,241...3,246,453
Ensembl chr15:2,863,244...3,246,510
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G |
Adora1 |
adenosine A1 receptor |
affects response to substance |
ISO |
ADORA1 polymorphism affects the susceptibility to Aspirin |
CTD |
PMID:19019667 |
|
NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801
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G |
Adora2a |
adenosine A2a receptor |
affects response to substance |
ISO |
ADORA2A polymorphism affects the susceptibility to Aspirin |
CTD |
PMID:19019667 |
|
NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
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G |
Adora3 |
adenosine A3 receptor |
affects response to substance |
ISO |
ADORA3 protein affects the susceptibility to Aspirin |
CTD |
PMID:20716228 |
|
NCBI chr 2:193,352,759...193,392,946
Ensembl chr 2:193,388,713...193,392,357
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G |
Adrb2 |
adrenoceptor beta 2 |
affects response to substance |
ISO |
ADRB2 polymorphism affects the susceptibility to Aspirin; ADRB2 SNP affects the susceptibility to Aspirin |
CTD |
PMID:18159608 PMID:18379861 |
|
NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
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G |
Agt |
angiotensinogen |
affects activity |
ISO |
Aspirin affects the activity of AGT protein |
CTD |
PMID:3189434 |
|
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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G |
Agtr1a |
angiotensin II receptor, type 1a |
multiple interactions |
ISO |
Aspirin inhibits the reaction [Hydrogen Peroxide results in increased expression of AGTR1A mRNA] |
CTD |
PMID:22306536 |
|
NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
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G |
Ahr |
aryl hydrocarbon receptor |
increases expression multiple interactions |
ISO EXP |
Aspirin results in increased expression of AHR mRNA AHR mutant form inhibits the reaction [Aspirin results in increased activity of PON1 protein]; AHR mutant form inhibits the reaction [Aspirin results in increased expression of APOA1 mRNA]; AHR mutant form inhibits the reaction [Aspirin results in increased expression of PON1 mRNA] |
CTD |
PMID:18519978 |
|
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Aif1l |
allograft inflammatory factor 1-like |
increases expression |
ISO |
Aspirin results in increased expression of AIF1L mRNA |
CTD |
PMID:11906190 |
|
NCBI chr 3:15,229,476...15,254,033
Ensembl chr 3:15,229,524...15,254,023
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G |
Aimp2 |
aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 |
decreases expression |
EXP |
Aspirin results in decreased expression of AIMP2 mRNA |
CTD |
PMID:12800193 |
|
NCBI chr12:10,701,194...10,710,772
Ensembl chr12:10,701,194...10,710,769
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G |
Akr1c1 |
aldo-keto reductase family 1, member C1 |
decreases activity |
ISO |
Aspirin results in decreased activity of AKR1C1 protein |
CTD |
PMID:19010312 |
|
NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
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G |
Akr1c2 |
aldo-keto reductase family 1, member C2 |
decreases activity |
ISO |
Aspirin results in decreased activity of AKR1C2 protein |
CTD |
PMID:19010312 |
|
NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
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G |
Akr1c3 |
aldo-keto reductase family 1, member C3 |
decreases activity |
ISO |
Aspirin results in decreased activity of AKR1C3 protein |
CTD |
PMID:19010312 |
|
NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions increases expression increases activity |
ISO |
[troglitazone co-treated with Aspirin] results in decreased expression of AKT1 protein; [troglitazone co-treated with Aspirin] results in decreased expression of AKT1 protein modified form; Aspirin results in decreased phosphorylation of and results in decreased activity of AKT1 protein Aspirin results in increased expression of AKT1 mRNA Aspirin results in increased activity of AKT1 protein |
CTD |
PMID:19908241 PMID:20116423 PMID:20457246 PMID:21617849 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Akt2 |
AKT serine/threonine kinase 2 |
increases expression |
ISO |
Aspirin results in increased expression of AKT2 mRNA |
CTD |
PMID:11906190 |
|
NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
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G |
Alas1 |
5'-aminolevulinate synthase 1 |
increases expression |
EXP |
Aspirin results in increased expression of ALAS1 mRNA |
CTD |
PMID:12800193 |
|
NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917
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G |
Alb |
albumin |
multiple interactions decreases secretion |
ISO |
ALB protein binds to and affects the transport of Aspirin; Aspirin inhibits the reaction [Adenosine Diphosphate results in decreased secretion of ALB protein]; Aspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of ALB protein]; Aspirin inhibits the reaction [Warfarin binds to ALB protein]; Aspirin inhibits the reaction [zomepirac glucuronide binds to ALB protein]; Aspirin promotes the reaction [menadione epoxide analog binds to ALB protein] Aspirin results in decreased secretion of ALB protein |
CTD |
PMID:1981713 PMID:8831264 PMID:17303692 PMID:25499135 |
|
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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G |
Aldh1a1 |
aldehyde dehydrogenase 1 family, member A1 |
affects binding |
EXP |
Aspirin binds to ALDH1A1 protein |
CTD |
PMID:15236443 |
|
NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
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G |
Aldoa |
aldolase, fructose-bisphosphate A |
decreases expression |
ISO |
Aspirin results in decreased expression of ALDOA mRNA |
CTD |
PMID:15928584 |
|
NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182
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G |
Angptl3 |
angiopoietin-like 3 |
decreases expression |
ISO |
Aspirin results in decreased expression of ANGPTL3 mRNA |
CTD |
PMID:27089845 |
|
NCBI chr 5:113,703,007...113,710,044
Ensembl chr 5:113,703,012...113,709,957
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G |
Ano9 |
anoctamin 9 |
increases expression |
ISO |
Aspirin results in increased expression of ANO9 mRNA |
CTD |
PMID:11906190 |
|
NCBI chr 1:196,208,863...196,230,381
Ensembl chr 1:196,197,341...196,229,900
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G |
Anpep |
alanyl aminopeptidase, membrane |
increases activity increases expression |
ISO |
Aspirin results in increased activity of ANPEP protein Aspirin results in increased expression of ANPEP mRNA; Aspirin results in increased expression of ANPEP protein |
CTD |
PMID:16216591 |
|
NCBI chr 1:133,767,332...133,810,137
Ensembl chr 1:133,767,332...133,785,789
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G |
Ap2b1 |
adaptor related protein complex 2 subunit beta 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of AP2B1 mRNA |
CTD |
PMID:11906190 |
|
NCBI chr10:68,099,397...68,205,023
Ensembl chr10:68,099,547...68,205,013
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G |
Apaf1 |
apoptotic peptidase activating factor 1 |
increases response to substance increases expression |
ISO |
APAF1 results in increased susceptibility to Aspirin Aspirin results in increased expression of APAF1 mRNA |
CTD |
PMID:11228543 PMID:20457246 |
|
NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
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G |
Apoa1 |
apolipoprotein A1 |
multiple interactions increases expression increases activity |
ISO EXP |
AHR mutant form inhibits the reaction [Aspirin results in increased expression of APOA1 mRNA]; Aspirin promotes the reaction [APOA1 affects the transport of Cholesterol]; PPARA affects the reaction [Aspirin promotes the reaction [APOA1 affects the transport of Cholesterol]] Aspirin results in increased activity of APOA1 mRNA |
CTD |
PMID:9399670 PMID:18519978 PMID:21088444 |
|
NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
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G |
Apoc1 |
apolipoprotein C1 |
multiple interactions |
ISO |
Aspirin inhibits the reaction [APOC1 results in increased abundance of Triglycerides] |
CTD |
PMID:21862721 |
|
NCBI chr 1:79,347,057...79,350,340
Ensembl chr 1:79,346,136...79,350,375
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G |
Apoe |
apolipoprotein E |
affects response to substance multiple interactions |
ISO |
APOE polymorphism affects the susceptibility to Aspirin Aspirin inhibits the reaction [APOE gene mutant form results in decreased susceptibility to Arachidonic Acid] Aspirin inhibits the reaction [APOE gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]] |
CTD |
PMID:15084783 PMID:20530721 |
|
NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
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G |
App |
amyloid beta precursor protein |
multiple interactions |
ISO |
Aspirin inhibits the reaction [[Benzo(a)pyrene affects the expression of APP protein] which results in increased abundance of amyloid beta-protein (1-42)] |
CTD |
PMID:37364758 |
|
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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G |
Aprt |
adenine phosphoribosyl transferase |
decreases expression |
ISO |
Aspirin results in decreased expression of APRT mRNA |
CTD |
PMID:15928584 |
|
NCBI chr19:50,626,201...50,628,491
Ensembl chr19:50,626,202...50,628,431
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G |
Arl6ip5 |
ARF like GTPase 6 interacting protein 5 |
increases expression |
ISO |
Aspirin results in increased expression of ARL6IP5 mRNA |
CTD |
PMID:15928584 |
|
NCBI chr 4:129,810,650...129,838,628
Ensembl chr 4:129,810,645...129,838,608
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G |
Arpp19 |
cAMP-regulated phosphoprotein 19 |
increases expression |
ISO |
Aspirin results in increased expression of ARPP19 mRNA |
CTD |
PMID:15928584 |
|
NCBI chr 8:75,779,640...75,802,474
Ensembl chr 8:75,779,523...75,802,452 Ensembl chr 8:75,779,523...75,802,452
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G |
Asic1 |
acid sensing ion channel subunit 1 |
decreases expression |
EXP |
Aspirin results in decreased expression of ASIC1 mRNA |
CTD |
PMID:11588175 |
|
NCBI chr 7:130,798,317...130,828,535
Ensembl chr 7:130,799,917...130,828,541
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G |
Asic2 |
acid sensing ion channel subunit 2 |
decreases expression |
EXP |
Aspirin results in decreased expression of ASIC2 mRNA |
CTD |
PMID:11588175 |
|
NCBI chr10:65,870,592...66,940,577
Ensembl chr10:65,870,594...66,940,424
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G |
Asic3 |
acid sensing ion channel subunit 3 |
decreases expression decreases activity |
EXP |
Aspirin results in decreased expression of ASIC3 mRNA Aspirin results in decreased activity of ASIC3 protein |
CTD |
PMID:11588175 |
|
NCBI chr 4:10,760,509...10,764,987
Ensembl chr 4:10,760,597...10,764,643
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G |
Asl |
argininosuccinate lyase |
decreases expression |
ISO |
Aspirin results in decreased expression of ASL mRNA |
CTD |
PMID:15928584 |
|
NCBI chr12:26,659,664...26,677,136
Ensembl chr12:26,659,565...26,679,662
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G |
Astn2 |
astrotactin 2 |
increases expression |
ISO |
Aspirin results in increased expression of ASTN2 mRNA |
CTD |
PMID:11906190 |
|
NCBI chr 5:78,758,142...79,744,021
Ensembl chr 5:78,758,142...79,748,273
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G |
Atf4 |
activating transcription factor 4 |
decreases expression |
ISO |
Aspirin results in decreased expression of ATF4 mRNA |
CTD |
PMID:15928584 |
|
NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
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G |
Atm |
ATM serine/threonine kinase |
increases expression |
ISO |
Aspirin results in increased expression of ATM mRNA |
CTD |
PMID:20457246 |
|
NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
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G |
Atp2a1 |
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 |
increases expression |
ISO |
Aspirin results in increased expression of ATP2A1 mRNA |
CTD |
PMID:11906190 |
|
NCBI chr 1:181,026,606...181,044,859
Ensembl chr 1:181,026,608...181,044,838
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G |
Atp5f1e |
ATP synthase F1 subunit epsilon |
increases expression |
ISO |
Aspirin results in increased expression of ATP5F1E mRNA |
CTD |
PMID:15928584 |
|
NCBI chr 3:163,259,072...163,261,974
Ensembl chr 3:163,260,476...163,261,450
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G |
Atp6v0b |
ATPase H+ transporting V0 subunit B |
decreases expression |
ISO |
Aspirin results in decreased expression of ATP6V0B mRNA |
CTD |
PMID:15928584 |
|
NCBI chr 5:131,423,384...131,424,900
Ensembl chr 5:131,423,387...131,426,401
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G |
Atp6v0d1 |
ATPase H+ transporting V0 subunit D1 |
decreases expression |
ISO |
Aspirin results in decreased expression of ATP6V0D1 mRNA |
CTD |
PMID:15928584 |
|
NCBI chr19:33,403,352...33,447,357
Ensembl chr19:33,403,355...33,447,450
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Atr |
ATR serine/threonine kinase |
decreases expression |
ISO |
Aspirin results in decreased expression of ATR mRNA |
CTD |
PMID:20514442 |
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NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136
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Atraid |
all-trans retinoic acid-induced differentiation factor |
decreases expression |
ISO |
Aspirin results in decreased expression of ATRAID mRNA |
CTD |
PMID:15928584 |
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NCBI chr 6:25,315,236...25,319,821
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Aurka |
aurora kinase A |
increases expression |
ISO |
Aspirin results in increased expression of AURKA mRNA |
CTD |
PMID:11906190 |
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NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390
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B2m |
beta-2 microglobulin |
increases expression |
ISO |
Aspirin results in increased expression of B2M mRNA |
CTD |
PMID:15456535 |
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NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766
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B4galt1 |
beta-1,4-galactosyltransferase 1 |
increases expression |
ISO |
Aspirin results in increased expression of B4GALT1 mRNA |
CTD |
PMID:15456535 |
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NCBI chr 5:55,935,614...55,982,461
Ensembl chr 5:55,935,615...55,982,461
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Bad |
BCL2-associated agonist of cell death |
decreases expression |
ISO |
Aspirin results in decreased expression of BAD mRNA |
CTD |
PMID:20457246 |
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NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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Bak1 |
BCL2-antagonist/killer 1 |
increases expression |
ISO |
Aspirin results in increased expression of BAK1 protein |
CTD |
PMID:11532860 |
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NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
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G |
Bap1 |
BRCA1 associated deubiquitinase 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of BAP1 mRNA |
CTD |
PMID:15928584 |
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NCBI chr16:6,446,709...6,455,535
Ensembl chr16:6,446,709...6,455,535
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Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions increases expression increases localization decreases expression |
ISO EXP |
Aspirin promotes the reaction [Fluorouracil results in increased expression of BAX protein]; CASP8 affects the reaction [Aspirin results in increased localization of BAX protein]; Fluorouracil promotes the reaction [Aspirin results in increased expression of BAX protein] Aspirin inhibits the reaction [Cisplatin results in increased expression of BAX protein] Bee Venoms inhibits the reaction [Aspirin results in increased expression of BAX protein]; Ranitidine inhibits the reaction [Aspirin results in increased expression of BAX protein] Aspirin results in decreased expression of BAX mRNA; Aspirin results in decreased expression of BAX protein |
CTD |
PMID:11228543 PMID:11532860 PMID:15976387 PMID:15986848 PMID:16880202 PMID:18636671 PMID:19212664 PMID:20457246 PMID:30885738 PMID:37179038 More...
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Baz1b |
bromodomain adjacent to zinc finger domain, 1B |
decreases expression |
ISO |
Aspirin results in decreased expression of BAZ1B mRNA |
CTD |
PMID:15928584 |
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NCBI chr12:21,431,985...21,489,956
Ensembl chr12:21,431,985...21,490,426
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G |
Bbc3 |
Bcl-2 binding component 3 |
increases expression increases response to substance |
ISO |
Aspirin results in increased expression of BBC3 mRNA BBC3 results in increased susceptibility to Aspirin |
CTD |
PMID:19936928 |
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NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
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G |
Bbln |
bublin coiled coil protein |
increases expression |
ISO |
Aspirin results in increased expression of BBLN mRNA |
CTD |
PMID:11906190 |
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NCBI chr 3:15,674,577...15,677,322
Ensembl chr 3:15,674,580...15,677,374
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G |
Bbof1 |
basal body orientation factor 1 |
increases expression |
ISO |
Aspirin results in increased expression of BBOF1 mRNA |
CTD |
PMID:11906190 |
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NCBI chr 6:104,055,246...104,081,036
Ensembl chr 6:104,055,241...104,082,071
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G |
Bcar3 |
BCAR3 adaptor protein, NSP family member |
increases expression |
ISO |
Aspirin results in increased expression of BCAR3 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 2:210,525,260...210,638,674
Ensembl chr 2:210,525,260...210,638,798
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions decreases expression increases expression |
ISO EXP |
Aspirin inhibits the reaction [Methotrexate results in decreased expression of BCL2 protein]; BCL2 protein inhibits the reaction [[TNFSF10 protein co-treated with Aspirin] results in increased cleavage of and results in increased activity of CASP3 protein]; BCL2 protein inhibits the reaction [[TNFSF10 protein co-treated with Aspirin] results in increased cleavage of and results in increased activity of CASP9 protein]; BCL2 protein inhibits the reaction [Aspirin promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]] Aspirin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of BCL2 protein]; Aspirin inhibits the reaction [Cisplatin results in decreased expression of BCL2 mRNA]; Aspirin inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein] Aspirin results in decreased expression of BCL2 mRNA; Aspirin results in decreased expression of BCL2 protein Aspirin inhibits the reaction [Azoxymethane results in increased expression of BCL2 mRNA] Aspirin results in increased expression of BCL2 mRNA; Aspirin results in increased expression of BCL2 protein |
CTD |
PMID:12490308 PMID:14636445 PMID:15976387 PMID:16199534 PMID:17342322 PMID:18564172 PMID:18636671 PMID:19424877 PMID:19595669 PMID:19966835 PMID:20043115 PMID:20457246 PMID:20886344 PMID:23799623 PMID:25449198 PMID:37179038 More...
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2l1 |
Bcl2-like 1 |
decreases expression increases expression |
ISO |
Aspirin results in decreased expression of BCL2L1 protein Aspirin results in increased expression of BCL2L1 mRNA |
CTD |
PMID:17342322 PMID:20457246 PMID:20886344 |
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NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 Ensembl chr 1:141,253,523...141,303,479
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G |
Bcl2l11 |
Bcl2-like 11 |
increases expression |
ISO |
Aspirin results in increased expression of BCL2L11 mRNA |
CTD |
PMID:19936928 |
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NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
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G |
Bdnf |
brain-derived neurotrophic factor |
multiple interactions |
ISO |
Aspirin inhibits the reaction [Benzo(a)pyrene results in decreased expression of BDNF mRNA alternative form]; Aspirin inhibits the reaction [Benzo(a)pyrene results in decreased expression of BDNF mRNA]; Aspirin inhibits the reaction [Benzo(a)pyrene results in decreased expression of BDNF protein]; Aspirin inhibits the reaction [Benzo(a)pyrene results in increased methylation of BDNF promoter alternative form] |
CTD |
PMID:34979192 PMID:37364758 |
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NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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G |
Bid |
BH3 interacting domain death agonist |
multiple interactions increases cleavage |
ISO |
[Aspirin co-treated with TNFSF10 protein] results in increased cleavage of BID protein; CASP8 affects the reaction [Aspirin results in increased cleavage of BID protein] |
CTD |
PMID:15976387 PMID:18483385 |
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NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
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G |
Bin1 |
bridging integrator 1 |
increases expression |
EXP |
Aspirin results in increased expression of BIN1 mRNA |
CTD |
PMID:12800193 |
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NCBI chr18:24,009,731...24,067,267
Ensembl chr18:24,009,653...24,067,263
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G |
Birc5 |
baculoviral IAP repeat-containing 5 |
multiple interactions increases expression decreases expression |
ISO |
[Aspirin co-treated with TNFSF10 protein] results in decreased expression of BIRC5 protein; Aspirin inhibits the reaction [E2F1 protein binds to BIRC5 promoter]; epoxomicin inhibits the reaction [Aspirin results in decreased expression of BIRC5 protein] Aspirin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of BIRC5 protein] Aspirin results in increased expression of BIRC5 mRNA Aspirin results in decreased expression of BIRC5 mRNA; Aspirin results in decreased expression of BIRC5 protein |
CTD |
PMID:11906190 PMID:17342322 PMID:17848598 PMID:18483385 PMID:25449198 |
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NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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G |
Blmh |
bleomycin hydrolase |
decreases expression |
ISO |
Aspirin results in decreased expression of BLMH mRNA |
CTD |
PMID:14976132 |
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NCBI chr10:61,772,112...61,815,212
Ensembl chr10:61,758,478...61,815,212
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G |
Bmf |
Bcl2 modifying factor |
increases expression |
ISO |
Aspirin results in increased expression of BMF mRNA |
CTD |
PMID:19936928 |
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NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145
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G |
Bmp6 |
bone morphogenetic protein 6 |
increases expression |
ISO |
Aspirin results in increased expression of BMP6 mRNA |
CTD |
PMID:32816093 |
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NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365
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G |
Bnip3l |
BCL2 interacting protein 3 like |
increases expression |
ISO |
Aspirin results in increased expression of BNIP3L mRNA |
CTD |
PMID:15928584 |
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NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803
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G |
Brca1 |
BRCA1, DNA repair associated |
decreases expression |
ISO |
Aspirin results in decreased expression of BRCA1 mRNA |
CTD |
PMID:20457246 PMID:20514442 |
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NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
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G |
Brd4 |
bromodomain containing 4 |
increases expression |
ISO |
Aspirin results in increased expression of BRD4 mRNA |
CTD |
PMID:11906190 |
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NCBI chr 7:11,216,446...11,296,029
Ensembl chr 7:11,216,446...11,295,539
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G |
Btg1 |
BTG anti-proliferation factor 1 |
increases expression |
ISO EXP |
Aspirin results in increased expression of BTG1 mRNA |
CTD |
PMID:12800193 PMID:15928584 |
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NCBI chr 7:31,341,391...31,343,649
Ensembl chr 7:31,341,027...31,343,649
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G |
Bzw1 |
basic leucine zipper and W2 domains 1 |
increases expression |
ISO |
Aspirin results in increased expression of BZW1 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 9:59,930,672...59,944,468
Ensembl chr 9:59,930,744...59,944,430
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G |
Cacng1 |
calcium voltage-gated channel auxiliary subunit gamma 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of CACNG1 mRNA |
CTD |
PMID:11906190 |
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NCBI chr10:92,652,924...92,665,612
Ensembl chr10:92,652,614...92,665,783
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G |
Cacng6 |
calcium voltage-gated channel auxiliary subunit gamma 6 |
affects response to substance |
ISO |
CACNG6 polymorphism affects the susceptibility to Aspirin |
CTD |
PMID:20860846 |
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NCBI chr 1:65,732,910...65,747,377
Ensembl chr 1:65,732,632...65,747,341
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G |
Calca |
calcitonin-related polypeptide alpha |
decreases expression |
EXP |
Aspirin results in decreased expression of CALCA mRNA |
CTD |
PMID:11588175 |
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NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
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G |
Calm1 |
calmodulin 1 |
multiple interactions |
ISO |
Aspirin promotes the reaction [NOS3 protein binds to CALM1 protein]; HDAC3 protein inhibits the reaction [Aspirin promotes the reaction [NOS3 protein binds to CALM1 protein]] |
CTD |
PMID:20705923 |
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NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227
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G |
Calm3 |
calmodulin 3 |
increases expression |
ISO |
Aspirin results in increased expression of CALM3 mRNA |
CTD |
PMID:11906190 |
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NCBI chr 1:77,590,668...77,597,776
Ensembl chr 1:77,589,230...77,592,207
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G |
Canx |
calnexin |
decreases expression |
ISO |
Aspirin results in decreased expression of CANX mRNA |
CTD |
PMID:15928584 |
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NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821
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G |
Capn1 |
calpain 1 |
increases expression |
ISO |
Aspirin results in increased expression of CAPN1 mRNA |
CTD |
PMID:19266085 |
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NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177
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G |
Capn2 |
calpain 2 |
increases expression |
ISO |
Aspirin results in increased expression of CAPN2 mRNA |
CTD |
PMID:15928584 |
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NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969
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G |
Capns1 |
calpain, small subunit 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of CAPNS1 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 1:85,444,613...85,454,861
Ensembl chr 1:85,444,608...85,454,795
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G |
Capsl |
calcyphosine-like |
increases expression |
ISO |
Aspirin results in increased expression of CAPSL mRNA |
CTD |
PMID:11906190 |
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NCBI chr 2:58,394,995...58,425,527
Ensembl chr 2:58,411,424...58,424,980
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G |
Capza1 |
capping actin protein of muscle Z-line subunit alpha 1 |
increases expression |
ISO |
Aspirin results in increased expression of CAPZA1 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 2:192,319,696...192,364,755
Ensembl chr 2:192,319,702...192,364,480
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G |
Capza2 |
capping actin protein of muscle Z-line subunit alpha 2 |
increases expression |
ISO |
Aspirin results in increased expression of CAPZA2 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 4:45,978,142...46,014,032
Ensembl chr 4:45,977,807...46,013,864
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G |
Casp3 |
caspase 3 |
increases activity multiple interactions increases expression decreases expression |
ISO EXP |
Aspirin results in increased activity of CASP3 protein Aspirin inhibits the reaction [Cisplatin results in increased expression of CASP3 protein] Bee Venoms inhibits the reaction [Aspirin results in increased expression of CASP3 mRNA]; Bee Venoms inhibits the reaction [Aspirin results in increased expression of CASP3 protein]; Ranitidine inhibits the reaction [Aspirin results in increased expression of CASP3 mRNA]; Ranitidine inhibits the reaction [Aspirin results in increased expression of CASP3 protein] Aspirin results in increased expression of CASP3 mRNA; Aspirin results in increased expression of CASP3 protein [Aspirin co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP3 protein; [TNFSF10 protein co-treated with Aspirin] results in increased cleavage of and results in increased activity of CASP3 protein; [troglitazone co-treated with Aspirin] results in increased cleavage of and results in increased activity of CASP3 protein; Aspirin inhibits the reaction [Deoxycholic Acid results in increased activity of CASP3 protein]; Aspirin inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; Aspirin inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]; Aspirin inhibits the reaction [Methotrexate results in decreased expression of CASP3 protein]; Aspirin results in increased cleavage of and results in increased activity of CASP3 protein; BCL2 protein inhibits the reaction [[TNFSF10 protein co-treated with Aspirin] results in increased cleavage of and results in increased activity of CASP3 protein]; CDKN1A mutant form inhibits the reaction [Aspirin inhibits the reaction [Etoposide results in increased activity of CASP3 protein]] Aspirin results in decreased expression of CASP3 mRNA |
CTD |
PMID:11034327 PMID:11228543 PMID:11532860 PMID:12490308 PMID:14753751 PMID:15481331 PMID:16199534 PMID:16880202 PMID:17644113 PMID:18483385 PMID:19908241 PMID:21353610 PMID:21617849 PMID:23799623 PMID:30885738 PMID:37179038 More...
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp6 |
caspase 6 |
multiple interactions |
ISO |
Aspirin inhibits the reaction [Deoxycholic Acid results in increased activity of CASP6 protein]; Aspirin results in increased cleavage of and results in increased activity of CASP6 protein |
CTD |
PMID:15481331 PMID:17644113 |
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NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
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G |
Casp7 |
caspase 7 |
multiple interactions |
ISO |
Aspirin results in increased cleavage of and results in increased activity of CASP7 protein |
CTD |
PMID:15481331 |
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NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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G |
Casp8 |
caspase 8 |
multiple interactions increases expression increases activity |
ISO |
[Aspirin co-treated with TNFSF10 protein] results in increased activity of CASP8 protein; [Aspirin co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP8 protein; [TNFSF10 protein co-treated with Aspirin] results in increased cleavage of CASP8 protein; Aspirin results in increased cleavage of and results in increased activity of CASP8 protein; CASP8 affects the reaction [Aspirin results in increased cleavage of BID protein]; CASP8 affects the reaction [Aspirin results in increased localization of BAX protein] Aspirin results in increased expression of CASP8 mRNA Aspirin results in increased activity of CASP8 protein |
CTD |
PMID:11034327 PMID:15481331 PMID:15976387 PMID:16199534 PMID:18483385 PMID:20457246 PMID:21171083 More...
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
multiple interactions increases activity |
ISO |
[TNFSF10 protein co-treated with Aspirin] results in increased cleavage of and results in increased activity of CASP9 protein; Aspirin inhibits the reaction [Deoxycholic Acid results in increased activity of CASP9 protein]; Aspirin inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP9 protein]; Aspirin results in increased cleavage of and results in increased activity of CASP9 protein; BCL2 protein inhibits the reaction [[TNFSF10 protein co-treated with Aspirin] results in increased cleavage of and results in increased activity of CASP9 protein] Aspirin results in increased activity of CASP9 protein |
CTD |
PMID:11034327 PMID:14753751 PMID:15481331 PMID:16199534 PMID:16880202 PMID:17644113 More...
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cat |
catalase |
decreases activity increases expression |
EXP |
Aspirin results in decreased activity of CAT; Aspirin results in decreased activity of CAT protein Aspirin results in increased expression of CAT protein |
CTD |
PMID:6845354 PMID:9212780 PMID:10528994 PMID:17147060 PMID:17274466 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Cav1 |
caveolin 1 |
decreases expression |
EXP |
Aspirin results in decreased expression of CAV1 mRNA |
CTD |
PMID:12800193 |
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NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
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G |
Ccl19 |
C-C motif chemokine ligand 19 |
increases expression |
ISO |
Aspirin results in increased expression of CCL19 mRNA |
CTD |
PMID:11906190 |
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NCBI chr 5:56,963,364...56,965,308
Ensembl chr 5:56,963,364...56,965,308
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO EXP |
Aspirin inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]; Aspirin inhibits the reaction [Glucose results in increased expression of CCL2 protein]; Aspirin inhibits the reaction [Glucose results in increased secretion of CCL2 protein]; Aspirin inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]; Aspirin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]; Aspirin inhibits the reaction [TNF results in increased secretion of CCL2 protein] Aspirin inhibits the reaction [Oxaliplatin results in increased expression of CCL2 mRNA] |
CTD |
PMID:15136050 PMID:16600694 PMID:24211328 PMID:35574720 |
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccl3 |
C-C motif chemokine ligand 3 |
decreases expression |
ISO |
Aspirin results in decreased expression of CCL3 mRNA |
CTD |
PMID:21353610 |
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NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
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G |
Ccn2 |
cellular communication network factor 2 |
multiple interactions |
EXP |
Aspirin inhibits the reaction [Glucose results in increased expression of CCN2 mRNA]; Aspirin inhibits the reaction [Streptozocin results in increased expression of CCN2 mRNA] |
CTD |
PMID:14586741 |
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NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
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G |
Ccna2 |
cyclin A2 |
multiple interactions |
ISO |
Aspirin inhibits the reaction [Methotrexate results in increased expression of CCNA2 protein] |
CTD |
PMID:23799623 |
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NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
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G |
Ccnb1 |
cyclin B1 |
multiple interactions increases expression |
ISO |
Aspirin inhibits the reaction [troglitazone results in decreased expression of CCNB1 protein] Aspirin results in increased expression of CCNB1 mRNA |
CTD |
PMID:11906190 PMID:19908241 |
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NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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G |
Ccnd1 |
cyclin D1 |
multiple interactions decreases expression increases expression |
ISO EXP |
Aspirin inhibits the reaction [Smoke analog results in increased expression of CCND1 protein]; Aspirin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; CTNNB1 affects the reaction [Aspirin results in decreased expression of CCND1 protein] Aspirin results in decreased expression of CCND1 mRNA; Aspirin results in decreased expression of CCND1 protein Aspirin results in increased expression of CCND1 mRNA |
CTD |
PMID:11313997 PMID:11593435 PMID:12800193 PMID:15489888 PMID:16878161 PMID:17357503 PMID:19207549 PMID:19595669 PMID:19966835 PMID:21721879 More...
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Ccnd3 |
cyclin D3 |
multiple interactions decreases expression |
ISO |
Aspirin promotes the reaction [troglitazone results in decreased expression of CCND3 protein]; troglitazone promotes the reaction [Aspirin results in decreased expression of CCND3 protein] Aspirin results in decreased expression of CCND3 mRNA; Aspirin results in decreased expression of CCND3 protein |
CTD |
PMID:14976132 PMID:19908241 |
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NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
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Ccne1 |
cyclin E1 |
affects expression decreases expression |
EXP ISO |
Aspirin affects the expression of CCNE1 mRNA Aspirin results in decreased expression of CCNE1 mRNA |
CTD |
PMID:12800193 PMID:20457246 |
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NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
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Ccnj |
cyclin J |
increases expression |
ISO |
Aspirin results in increased expression of CCNJ mRNA |
CTD |
PMID:11906190 |
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NCBI chr 1:239,659,588...239,677,367
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Ccr3 |
C-C motif chemokine receptor 3 |
affects response to substance increases expression |
ISO |
CCR3 gene SNP affects the susceptibility to Aspirin; CCR3 SNP affects the susceptibility to Aspirin Aspirin results in increased expression of CCR3 mRNA |
CTD |
PMID:18379861 PMID:20022477 PMID:20485159 |
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NCBI chr 8:123,586,100...123,634,178
Ensembl chr 8:123,616,236...123,634,990
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Cd151 |
CD151 molecule (Raph blood group) |
decreases expression |
ISO |
Aspirin results in decreased expression of CD151 protein |
CTD |
PMID:15381054 |
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NCBI chr 1:196,564,744...196,568,753
Ensembl chr 1:196,565,181...196,568,753
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Cd274 |
CD274 molecule |
increases expression |
ISO |
Aspirin results in increased expression of CD274 mRNA |
CTD |
PMID:11906190 |
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NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450
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Cd36 |
CD36 molecule |
decreases expression increases expression |
ISO EXP |
Aspirin results in decreased expression of CD36 protein Aspirin results in increased expression of CD36 mRNA |
CTD |
PMID:15140583 PMID:15381054 PMID:18222077 |
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NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
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Cd40lg |
CD40 ligand |
decreases expression |
ISO |
Aspirin results in decreased expression of CD40LG protein |
CTD |
PMID:15140583 PMID:15381054 |
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NCBI chr X:135,127,052...135,138,768
Ensembl chr X:135,126,969...135,138,306
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Cd44 |
CD44 molecule |
decreases expression multiple interactions |
ISO EXP |
Aspirin results in decreased expression of CD44 protein alternative form Aspirin results in decreased expression of CD44 mRNA CTNNB1 affects the reaction [Aspirin results in decreased expression of CD44 protein alternative form] |
CTD |
PMID:12800193 PMID:16878161 |
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NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
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G |
Cd55 |
CD55 molecule (Cromer blood group) |
affects expression |
EXP |
Aspirin affects the expression of CD55 mRNA |
CTD |
PMID:12800193 |
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NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831
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G |
Cd6 |
Cd6 molecule |
decreases expression |
ISO |
Aspirin results in decreased expression of CD6 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 1:207,442,873...207,481,703
Ensembl chr 1:207,442,877...207,481,634
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G |
Cd74 |
CD74 molecule |
decreases expression |
ISO |
Aspirin results in decreased expression of CD74 mRNA |
CTD |
PMID:15928584 |
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NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003
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G |
Cd8a |
CD8 subunit alpha |
decreases expression |
ISO |
Aspirin results in decreased expression of CD8A mRNA |
CTD |
PMID:15928584 |
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NCBI chr 4:103,365,804...103,370,041
Ensembl chr 4:103,365,804...103,370,040
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G |
Cdc25a |
cell division cycle 25A |
decreases expression |
ISO |
Aspirin results in decreased expression of CDC25A mRNA |
CTD |
PMID:20457246 |
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NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701
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G |
Cdc37 |
cell division cycle 37, HSP90 cochaperone |
decreases expression |
ISO |
Aspirin results in decreased expression of CDC37 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 8:19,677,400...19,690,761
Ensembl chr 8:19,671,938...19,690,809
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G |
Cdc42 |
cell division cycle 42 |
decreases expression |
ISO |
Aspirin results in decreased expression of CDC42 mRNA |
CTD |
PMID:14976132 |
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NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111
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G |
Cdh1 |
cadherin 1 |
affects methylation |
ISO |
Aspirin affects the methylation of CDH1 promoter |
CTD |
PMID:19184424 |
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NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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G |
Cdk19 |
cyclin-dependent kinase 19 |
increases expression |
ISO |
Aspirin results in increased expression of CDK19 mRNA |
CTD |
PMID:11906190 |
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NCBI chr20:43,770,409...43,910,629
Ensembl chr20:43,770,409...43,910,628
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G |
Cdk2 |
cyclin dependent kinase 2 |
decreases expression multiple interactions |
ISO |
Aspirin results in decreased expression of CDK2 mRNA; Aspirin results in decreased expression of CDK2 protein troglitazone promotes the reaction [Aspirin results in decreased expression of CDK2 protein] |
CTD |
PMID:19908241 PMID:20457246 |
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NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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G |
Cdk4 |
cyclin-dependent kinase 4 |
decreases expression |
ISO |
Aspirin results in decreased expression of CDK4 mRNA |
CTD |
PMID:20457246 |
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NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
multiple interactions decreases expression increases expression affects expression decreases activity |
ISO |
Aspirin inhibits the reaction [Camptothecin results in increased expression of CDKN1A protein]; Aspirin promotes the reaction [romidepsin results in increased expression of CDKN1A protein]; Aspirin results in increased expression of and results in increased phosphorylation of CDKN1A protein; CDKN1A mutant form inhibits the reaction [Aspirin inhibits the reaction [Etoposide results in increased activity of CASP3 protein]]; PTGS1 mutant form inhibits the reaction [Aspirin promotes the reaction [romidepsin results in increased expression of CDKN1A protein]]; wortmannin inhibits the reaction [Aspirin results in increased expression of CDKN1A protein] Aspirin results in decreased expression of CDKN1A mRNA Aspirin results in increased expression of CDKN1A mRNA; Aspirin results in increased expression of CDKN1A protein Aspirin affects the expression of CDKN1A protein Aspirin results in decreased activity of CDKN1A protein |
CTD |
PMID:14976132 PMID:15190207 PMID:19212664 PMID:19908241 PMID:20404564 PMID:20457246 PMID:21617849 More...
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
multiple interactions increases expression |
ISO |
[troglitazone co-treated with Aspirin] results in increased expression of CDKN1B protein Aspirin results in increased expression of CDKN1B protein |
CTD |
PMID:16880202 PMID:19908241 |
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NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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G |
Cds1 |
CDP-diacylglycerol synthase 1 |
increases expression |
EXP |
Aspirin results in increased expression of CDS1 mRNA |
CTD |
PMID:12800193 |
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NCBI chr14:7,820,328...7,882,943
Ensembl chr14:7,820,351...7,882,681
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G |
Cebpb |
CCAAT/enhancer binding protein beta |
multiple interactions |
ISO |
Aspirin promotes the reaction [CEBPB protein binds to IL4 promoter polymorphism] |
CTD |
PMID:20921925 |
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NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
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G |
Cenps |
centromere protein S |
increases expression |
ISO |
Aspirin results in increased expression of CENPS mRNA |
CTD |
PMID:15456535 |
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NCBI chr 5:159,563,917...159,573,534
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G |
Cep68 |
centrosomal protein 68 |
affects response to substance |
ISO |
CEP68 SNP affects the susceptibility to Aspirin |
CTD |
PMID:21072201 |
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NCBI chr14:94,447,973...94,470,533
Ensembl chr14:94,449,055...94,470,517
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G |
Ces1d |
carboxylesterase 1D |
multiple interactions |
ISO |
CES1 protein promotes the reaction [Aspirin results in increased expression of ACACA protein modified form]; CES1 protein promotes the reaction [Aspirin results in increased expression of PRKAA1 protein modified form] |
CTD |
PMID:25743752 |
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NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
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G |
Ces2c |
carboxylesterase 2C |
increases hydrolysis |
ISO |
CES2C protein results in increased hydrolysis of Aspirin |
CTD |
PMID:22513142 |
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NCBI chr 1:260,391,190...260,398,757
Ensembl chr 1:260,388,902...260,398,790
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G |
Ces2e |
carboxylesterase 2E |
increases hydrolysis |
ISO |
CES2E protein results in increased hydrolysis of Aspirin |
CTD |
PMID:22513142 |
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NCBI chr19:157,447...172,822
Ensembl chr19:157,407...172,856
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G |
Ces2h |
carboxylesterase 2H |
affects hydrolysis increases hydrolysis |
ISO |
CES2 protein affects the hydrolysis of Aspirin CES2 protein results in increased hydrolysis of Aspirin |
CTD |
PMID:9300133 PMID:18983829 |
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NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
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G |
Cflar |
CASP8 and FADD-like apoptosis regulator |
increases expression multiple interactions |
ISO |
Aspirin results in increased expression of CFLAR mRNA Aspirin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of CFLAR protein] |
CTD |
PMID:20457246 PMID:25449198 |
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NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
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G |
Chd2 |
chromodomain helicase DNA binding protein 2 |
increases expression |
ISO |
Aspirin results in increased expression of CHD2 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 1:127,188,146...127,317,041
Ensembl chr 1:127,190,059...127,300,502
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G |
Chek2 |
checkpoint kinase 2 |
increases expression |
ISO |
Aspirin results in increased expression of CHEK2 mRNA |
CTD |
PMID:20457246 |
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NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
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G |
Chmp1a |
charged multivesicular body protein 1A |
decreases expression |
ISO |
Aspirin results in decreased expression of CHMP1A mRNA |
CTD |
PMID:14976132 |
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NCBI chr19:51,238,153...51,246,433
Ensembl chr19:51,238,160...51,246,436
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G |
Chuk |
component of inhibitor of nuclear factor kappa B kinase complex |
multiple interactions decreases phosphorylation |
ISO EXP |
Aspirin inhibits the reaction [TNF protein results in increased activity of CHUK protein] Aspirin results in decreased phosphorylation of CHUK protein |
CTD |
PMID:15489888 PMID:16310244 |
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NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
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G |
Cks1b |
CDC28 protein kinase regulatory subunit 1B |
increases expression |
ISO |
Aspirin results in increased expression of CKS1B mRNA |
CTD |
PMID:14976132 |
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NCBI chr 2:174,833,025...174,837,614
Ensembl chr 2:174,833,050...174,837,636
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G |
Cldn7 |
claudin 7 |
increases expression |
EXP |
Aspirin results in increased expression of CLDN7 mRNA |
CTD |
PMID:12800193 |
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NCBI chr10:54,689,684...54,692,177
Ensembl chr10:54,689,987...54,692,171
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G |
Clip3 |
CAP-GLY domain containing linker protein 3 |
increases expression |
ISO |
Aspirin results in increased expression of CLIP3 mRNA |
CTD |
PMID:11906190 |
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NCBI chr 1:85,547,170...85,563,187
Ensembl chr 1:85,547,206...85,563,184
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G |
Clk2 |
CDC-like kinase 2 |
decreases expression |
ISO |
Aspirin results in decreased expression of CLK2 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 2:174,570,614...174,582,645
Ensembl chr 2:174,570,653...174,588,985
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G |
Clk3 |
CDC-like kinase 3 |
decreases expression |
ISO |
Aspirin results in decreased expression of CLK3 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 8:58,152,155...58,167,196
Ensembl chr 8:58,152,155...58,168,181
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G |
Col26a1 |
collagen type XXVI alpha 1 chain |
affects response to substance |
ISO |
COL26A1 polymorphism affects the susceptibility to Aspirin |
CTD |
PMID:21086123 |
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NCBI chr12:19,792,693...19,938,556
Ensembl chr12:19,792,728...19,938,556
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G |
Col3a1 |
collagen type III alpha 1 chain |
decreases expression |
ISO |
Aspirin results in decreased expression of COL3A1 mRNA |
CTD |
PMID:15456535 |
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NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
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G |
Col7a1 |
collagen type VII alpha 1 chain |
decreases expression |
ISO |
Aspirin results in decreased expression of COL7A1 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 8:109,604,877...109,637,249
Ensembl chr 8:109,604,861...109,637,252
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G |
Cpne1 |
copine 1 |
increases expression |
ISO |
Aspirin results in increased expression of CPNE1 mRNA |
CTD |
PMID:11906190 |
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NCBI chr 3:144,587,531...144,629,911
Ensembl chr 3:144,588,995...144,598,636
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G |
Cpt1a |
carnitine palmitoyltransferase 1A |
increases expression |
ISO |
Aspirin results in increased expression of CPT1A mRNA; Aspirin results in increased expression of CPT1A protein |
CTD |
PMID:25743752 |
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NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
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G |
Cracr2b |
calcium release activated channel regulator 2B |
increases expression |
ISO |
Aspirin results in increased expression of CRACR2B mRNA |
CTD |
PMID:11906190 |
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NCBI chr 1:196,558,407...196,563,961
Ensembl chr 1:196,558,588...196,563,771
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G |
Crebbp |
CREB binding protein |
increases expression |
ISO |
Aspirin results in increased expression of CREBBP mRNA |
CTD |
PMID:11906190 |
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NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
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G |
Csf3r |
colony stimulating factor 3 receptor |
decreases expression |
ISO |
Aspirin results in decreased expression of CSF3R mRNA |
CTD |
PMID:15928584 |
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NCBI chr 5:138,298,605...138,318,224
Ensembl chr 5:138,301,506...138,317,881
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G |
Csnk2a1 |
casein kinase 2 alpha 1 |
increases expression decreases expression |
ISO |
Aspirin results in increased expression of CSNK2A1 mRNA Aspirin results in decreased expression of CSNK2A1 mRNA |
CTD |
PMID:11906190 |
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NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696
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G |
Csta |
cystatin A |
increases expression |
ISO |
Aspirin results in increased expression of CSTA mRNA |
CTD |
PMID:15456535 PMID:15928584 |
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NCBI chr11:64,620,483...64,631,488
Ensembl chr11:64,620,483...64,631,488
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G |
Ctnnb1 |
catenin beta 1 |
increases phosphorylation decreases localization multiple interactions increases ubiquitination |
ISO |
Aspirin results in increased phosphorylation of CTNNB1 protein Aspirin results in decreased localization of CTNNB1 protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Aspirin results in increased ubiquitination of CTNNB1 protein]; CTNNB1 affects the reaction [Aspirin results in decreased expression of CCND1 protein]; CTNNB1 affects the reaction [Aspirin results in decreased expression of CD44 protein alternative form]; CTNNB1 affects the reaction [Aspirin results in decreased expression of CMET protein]; CTNNB1 affects the reaction [Aspirin results in decreased expression of MYC protein]; Lithium Chloride inhibits the reaction [Aspirin results in increased phosphorylation of CTNNB1 protein] |
CTD |
PMID:12813129 PMID:16878161 PMID:17357503 |
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NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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G |
Ctsb |
cathepsin B |
decreases expression |
ISO |
Aspirin results in decreased expression of CTSB mRNA |
CTD |
PMID:21353610 |
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NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
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G |
Cx3cl1 |
C-X3-C motif chemokine ligand 1 |
multiple interactions decreases expression |
ISO |
Aspirin inhibits the reaction [TNF results in increased expression of CX3CL1 mRNA]; Aspirin inhibits the reaction [TNF results in increased expression of CX3CL1 protein] Aspirin results in decreased expression of CX3CL1 mRNA; Aspirin results in decreased expression of CX3CL1 protein |
CTD |
PMID:19493461 PMID:19997773 |
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NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833
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G |
Cxcl1 |
C-X-C motif chemokine ligand 1 |
multiple interactions |
ISO |
Aspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of CXCL1 protein]; Aspirin promotes the reaction [IL1A results in increased expression of CXCL1 mRNA] |
CTD |
PMID:14742690 PMID:17303692 |
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NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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G |
Cxcl3 |
C-X-C motif chemokine ligand 3 |
multiple interactions |
ISO |
Aspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of CXCL1 protein]; Aspirin promotes the reaction [IL1A results in increased expression of CXCL1 mRNA] |
CTD |
PMID:14742690 PMID:17303692 |
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NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
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G |
Cxcl6 |
C-X-C motif chemokine ligand 6 |
increases expression |
EXP |
Aspirin results in increased expression of CXCL5 mRNA |
CTD |
PMID:12800193 |
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NCBI chr14:17,310,790...17,312,250
Ensembl chr14:17,310,426...17,313,093
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G |
Cyc1 |
cytochrome c-1 |
increases expression |
EXP |
Aspirin results in increased expression of CYC1 mRNA |
CTD |
PMID:8554334 |
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NCBI chr 7:108,067,106...108,069,483
Ensembl chr 7:108,067,115...108,069,479
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
increases expression |
EXP |
Aspirin results in increased expression of CYP2E1 mRNA |
CTD |
PMID:11752103 |
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NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Cysltr1 |
cysteinyl leukotriene receptor 1 |
increases expression multiple interactions affects response to substance |
ISO |
Aspirin results in increased expression of CYSLTR1 mRNA Aspirin inhibits the reaction [IL4 results in increased expression of CYSLTR1 mRNA] CYSLTR1 gene SNP affects the susceptibility to Aspirin; CYSLTR1 SNP affects the susceptibility to Aspirin |
CTD |
PMID:16630147 PMID:17641958 PMID:18379861 PMID:19767084 PMID:20485159 |
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NCBI chr X:71,661,421...71,690,012
Ensembl chr X:71,663,821...71,690,121
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G |
Cysltr2 |
cysteinyl leukotriene receptor 2 |
affects response to substance |
ISO |
CYSLTR2 gene SNP affects the susceptibility to Aspirin; CYSLTR2 polymorphism affects the susceptibility to Aspirin |
CTD |
PMID:15970796 PMID:20485159 |
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NCBI chr15:48,189,476...48,228,750
Ensembl chr15:48,189,073...48,304,136
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G |
Dap |
death-associated protein |
decreases expression |
ISO |
Aspirin results in decreased expression of DAP mRNA |
CTD |
PMID:15928584 |
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NCBI chr 2:82,199,206...82,251,771
Ensembl chr 2:82,199,280...82,251,752
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
increases expression |
ISO EXP |
Aspirin results in increased expression of DDIT3 mRNA |
CTD |
PMID:12800193 PMID:14976132 |
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NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Ddx18 |
DEAD-box helicase 18 |
decreases expression |
ISO |
Aspirin results in decreased expression of DDX18 mRNA |
CTD |
PMID:11906190 |
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NCBI chr13:32,729,697...32,743,161
Ensembl chr13:32,729,700...32,743,161
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G |
Ddx5 |
DEAD-box helicase 5 |
increases expression |
ISO |
Aspirin results in increased expression of DDX5 mRNA |
CTD |
PMID:15928584 |
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NCBI chr10:91,723,508...91,732,210
Ensembl chr10:91,723,508...91,732,283
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G |
Defa5 |
defensin alpha 5 |
increases expression |
EXP |
Aspirin results in increased expression of DEFA5 mRNA |
CTD |
PMID:20043115 |
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NCBI chr16:70,342,530...70,344,854
Ensembl chr16:70,342,530...70,344,836
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G |
Dek |
DEK proto-oncogene |
increases expression |
ISO |
Aspirin results in increased expression of DEK mRNA |
CTD |
PMID:15928584 |
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NCBI chr17:17,580,804...17,602,825
Ensembl chr17:17,580,843...17,602,808
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G |
Dennd5a |
DENN domain containing 5A |
increases expression |
ISO |
Aspirin results in increased expression of DENND5A mRNA |
CTD |
PMID:11906190 |
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NCBI chr 1:163,928,183...163,994,207
Ensembl chr 1:163,928,183...163,994,316
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G |
Diablo |
diablo, IAP-binding mitochondrial protein |
decreases expression |
ISO |
Aspirin results in decreased expression of DIABLO protein |
CTD |
PMID:15976387 |
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NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387
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G |
Dlst |
dihydrolipoamide S-succinyltransferase |
decreases expression |
ISO |
Aspirin results in decreased expression of DLST mRNA |
CTD |
PMID:11906190 |
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NCBI chr 6:104,758,511...104,783,296
Ensembl chr 6:104,758,631...104,783,296
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G |
Dnmt1 |
DNA methyltransferase 1 |
multiple interactions |
ISO |
Aspirin inhibits the reaction [Benzo(a)pyrene results in increased expression of DNMT1 mRNA]; Aspirin inhibits the reaction [Benzo(a)pyrene results in increased expression of DNMT1 protein] |
CTD |
PMID:34979192 |
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NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
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G |
Dnmt3a |
DNA methyltransferase 3 alpha |
multiple interactions |
ISO |
Aspirin inhibits the reaction [Benzo(a)pyrene results in increased expression of DNMT3A mRNA]; Aspirin inhibits the reaction [Benzo(a)pyrene results in increased expression of DNMT3A protein] |
CTD |
PMID:34979192 |
|
NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687
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G |
Dnmt3b |
DNA methyltransferase 3 beta |
multiple interactions |
ISO |
Aspirin inhibits the reaction [Benzo(a)pyrene results in increased expression of DNMT3B mRNA]; Aspirin inhibits the reaction [Benzo(a)pyrene results in increased expression of DNMT3B protein] |
CTD |
PMID:34979192 |
|
NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124
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G |
Dusp1 |
dual specificity phosphatase 1 |
affects expression |
EXP |
Aspirin affects the expression of DUSP1 mRNA |
CTD |
PMID:12800193 |
|
NCBI chr10:16,680,478...16,683,275
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G |
Dusp5 |
dual specificity phosphatase 5 |
affects expression |
EXP |
Aspirin affects the expression of DUSP5 mRNA |
CTD |
PMID:12800193 |
|
NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818
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G |
Dusp6 |
dual specificity phosphatase 6 |
increases expression |
EXP |
Aspirin results in increased expression of DUSP6 mRNA |
CTD |
PMID:12800193 |
|
NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185
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G |
E2f1 |
E2F transcription factor 1 |
multiple interactions decreases expression |
ISO |
[troglitazone co-treated with Aspirin] results in decreased expression of E2F1 protein; Aspirin inhibits the reaction [E2F1 protein binds to BIRC5 promoter] Aspirin results in decreased expression of E2F1 mRNA |
CTD |
PMID:17848598 PMID:19908241 PMID:20457246 |
|
NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
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G |
Ednrb |
endothelin receptor type B |
multiple interactions |
ISO |
Aspirin inhibits the reaction [IL1B results in increased activity of EDNRB] |
CTD |
PMID:12126971 |
|
NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
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G |
Eef1a1 |
eukaryotic translation elongation factor 1 alpha 1 |
increases expression |
ISO |
Aspirin results in increased expression of EEF1A1 mRNA |
CTD |
PMID:14976132 |
|
NCBI chr 8:79,341,554...79,344,784
Ensembl chr 8:79,341,557...79,344,839
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G |
Egfr |
epidermal growth factor receptor |
increases expression |
ISO |
Aspirin results in increased expression of EGFR mRNA |
CTD |
PMID:15456535 |
|
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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G |
Egr1 |
early growth response 1 |
increases expression |
EXP |
Aspirin results in increased expression of EGR1 mRNA |
CTD |
PMID:12800193 |
|
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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G |
Egr4 |
early growth response 4 |
decreases expression |
ISO |
Aspirin results in decreased expression of EGR4 mRNA |
CTD |
PMID:11906190 |
|
NCBI chr 4:118,047,869...118,050,328
Ensembl chr 4:118,047,869...118,050,328
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G |
Ehhadh |
enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase |
decreases expression |
ISO |
Aspirin results in decreased expression of EHHADH mRNA |
CTD |
PMID:27089845 |
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NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188
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G |
Ehmt2 |
euchromatic histone lysine methyltransferase 2 |
increases expression |
ISO |
Aspirin results in increased expression of EHMT2 mRNA |
CTD |
PMID:11906190 |
|
NCBI chr20:3,919,623...3,936,751
Ensembl chr20:3,919,624...3,941,547
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G |
Eif2s2 |
eukaryotic translation initiation factor 2 subunit beta |
increases expression |
ISO |
Aspirin results in increased expression of EIF2S2 mRNA |
CTD |
PMID:15928584 |
|
NCBI chr 3:143,374,652...143,395,460
Ensembl chr 3:143,373,686...143,395,432
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G |
Eif4ebp1 |
eukaryotic translation initiation factor 4E binding protein 1 |
multiple interactions |
ISO |
Aspirin results in decreased phosphorylation of and results in increased expression of EIF4EBP1 protein |
CTD |
PMID:23363784 |
|
NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
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G |
Elf4 |
E74 like ETS transcription factor 4 |
decreases expression |
ISO |
Aspirin results in decreased expression of ELF4 mRNA |
CTD |
PMID:15928584 |
|
NCBI chr X:127,587,401...127,639,063
Ensembl chr X:127,590,650...127,630,200
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G |
Elovl5 |
ELOVL fatty acid elongase 5 |
increases expression decreases expression |
ISO |
Aspirin results in increased expression of ELOVL5 mRNA Aspirin results in decreased expression of ELOVL5 mRNA |
CTD |
PMID:11906190 PMID:15928584 |
|
NCBI chr 8:78,790,846...78,857,307
Ensembl chr 8:78,790,846...78,857,284
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G |
Enpp2 |
ectonucleotide pyrophosphatase/phosphodiesterase 2 |
decreases expression |
EXP |
Aspirin results in decreased expression of ENPP2 mRNA |
CTD |
PMID:12800193 |
|
NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827
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G |
Entpd2 |
ectonucleoside triphosphate diphosphohydrolase 2 |
increases expression |
EXP |
Aspirin results in increased expression of ENTPD2 mRNA |
CTD |
PMID:12800193 |
|
NCBI chr 3:8,213,575...8,219,094
Ensembl chr 3:8,213,663...8,226,866
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G |
Entpd4 |
ectonucleoside triphosphate diphosphohydrolase 4 |
multiple interactions |
ISO |
Aspirin inhibits the reaction [Benzo(a)pyrene results in increased expression of ENTPD4 mRNA] |
CTD |
PMID:37364758 |
|
NCBI chr15:44,630,878...44,658,654
Ensembl chr15:44,630,873...44,658,706
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G |
Epdr1 |
ependymin related 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of EPDR1 mRNA |
CTD |
PMID:20457246 |
|
NCBI chr17:45,333,932...45,358,597
Ensembl chr17:45,333,956...45,358,594
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G |
Ephx2 |
epoxide hydrolase 2 |
multiple interactions |
ISO |
Aspirin promotes the reaction [EPHX2 gene mutant form results in decreased susceptibility to Lipopolysaccharides]; EPHX2 gene mutant form promotes the reaction [[Lipopolysaccharides co-treated with Aspirin] results in decreased abundance of 11,12-dihydroxyeicosatrienoic acid]; EPHX2 gene mutant form promotes the reaction [[Lipopolysaccharides co-treated with Aspirin] results in decreased abundance of 14,15-dihydroxyeicosatrienoic acid]; EPHX2 gene mutant form promotes the reaction [Aspirin inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]]; EPHX2 gene mutant form promotes the reaction [Aspirin inhibits the reaction [Lipopolysaccharides results in increased abundance of Prostaglandin D2]] |
CTD |
PMID:19896470 |
|
NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
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G |
Erbb2 |
erb-b2 receptor tyrosine kinase 2 |
decreases expression increases expression |
ISO |
Aspirin results in decreased expression of ERBB2 mRNA; Aspirin results in decreased expression of ERBB2 protein Aspirin results in increased expression of ERBB2 mRNA |
CTD |
PMID:19424877 PMID:20457246 |
|
NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
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G |
Erbin |
erbb2 interacting protein |
increases expression |
ISO |
Aspirin results in increased expression of ERBIN mRNA |
CTD |
PMID:15928584 |
|
NCBI chr 2:34,926,962...35,028,440
Ensembl chr 2:34,928,863...35,027,852
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G |
Ercc5 |
ERCC excision repair 5, endonuclease |
increases expression |
ISO |
Aspirin results in increased expression of ERCC5 mRNA |
CTD |
PMID:11906190 |
|
NCBI chr 9:46,309,477...46,354,478
Ensembl chr 9:46,309,389...46,354,472
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G |
Ereg |
epiregulin |
increases expression |
ISO |
Aspirin results in increased expression of EREG mRNA |
CTD |
PMID:32816093 |
|
NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062
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G |
Ets2 |
ETS proto-oncogene 2, transcription factor |
decreases expression |
ISO |
Aspirin results in decreased expression of ETS2 mRNA |
CTD |
PMID:20457246 |
|
NCBI chr11:35,021,536...35,038,322
Ensembl chr11:35,021,596...35,038,319
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G |
Evi2b |
ecotropic viral integration site 2B |
increases expression |
ISO |
Aspirin results in increased expression of EVI2B mRNA |
CTD |
PMID:15928584 |
|
NCBI chr10:64,472,693...64,474,311
Ensembl chr10:64,471,505...64,481,560
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G |
Ezr |
ezrin |
decreases expression |
ISO |
Aspirin results in decreased expression of EZR mRNA |
CTD |
PMID:14976132 |
|
NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505
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G |
F2 |
coagulation factor II, thrombin |
affects cleavage multiple interactions |
ISO |
Aspirin affects the cleavage of F2 protein ITGB3 polymorphism affects the reaction [Aspirin affects the cleavage of F2 protein] |
CTD |
PMID:16675000 |
|
NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
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G |
F2r |
coagulation factor II (thrombin) receptor |
decreases expression |
ISO |
Aspirin results in decreased expression of F2R protein |
CTD |
PMID:15140583 PMID:15381054 |
|
NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870
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G |
Fas |
Fas cell surface death receptor |
affects expression multiple interactions increases expression |
ISO EXP |
Aspirin affects the expression of FAS protein Aspirin inhibits the reaction [Methotrexate results in increased expression of FAS protein] Aspirin results in increased expression of FAS mRNA Aspirin inhibits the reaction [Azoxymethane results in increased expression of FAS mRNA] |
CTD |
PMID:15200494 PMID:20043115 PMID:20457246 PMID:23799623 |
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NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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G |
Faslg |
Fas ligand |
multiple interactions |
EXP |
Aspirin inhibits the reaction [Azoxymethane results in increased expression of FASLG mRNA] |
CTD |
PMID:20043115 |
|
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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G |
Fat3 |
FAT atypical cadherin 3 |
increases expression |
ISO |
Aspirin results in increased expression of FAT3 mRNA |
CTD |
PMID:11906190 |
|
NCBI chr 8:12,691,470...13,274,336
Ensembl chr 8:12,694,019...13,273,135
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G |
Fbxl3 |
F-box and leucine-rich repeat protein 3 |
increases expression |
ISO |
Aspirin results in increased expression of FBXL3 mRNA |
CTD |
PMID:15928584 |
|
NCBI chr15:79,906,795...79,926,678
Ensembl chr15:79,906,795...79,927,867
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G |
Fbxo11 |
F-box protein 11 |
increases expression |
ISO |
Aspirin results in increased expression of FBXO11 mRNA |
CTD |
PMID:15928584 |
|
NCBI chr 6:6,486,761...6,562,664
Ensembl chr 6:6,486,015...6,562,662
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G |
Fcer1a |
Fc epsilon receptor Ia |
affects response to substance multiple interactions |
ISO |
FCER1A gene SNP affects the susceptibility to Aspirin; FCER1A polymorphism affects the susceptibility to Aspirin Aspirin inhibits the reaction [IL4 results in increased expression of FCER1A mRNA] |
CTD |
PMID:17125826 PMID:19767084 PMID:20485159 |
|
NCBI chr13:85,686,099...85,692,394
Ensembl chr13:85,686,092...85,692,351
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G |
Fcer1g |
Fc epsilon receptor Ig |
decreases expression affects response to substance |
ISO |
Aspirin results in decreased expression of FCER1G mRNA FCER1G SNP affects the susceptibility to Aspirin |
CTD |
PMID:15928584 PMID:18534082 PMID:18595682 |
|
NCBI chr13:83,649,447...83,654,248
Ensembl chr13:83,649,449...83,671,443
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G |
Fdft1 |
farnesyl diphosphate farnesyl transferase 1 |
increases expression |
EXP |
Aspirin results in increased expression of FDFT1 mRNA |
CTD |
PMID:12800193 |
|
NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287
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G |
Fer |
FER tyrosine kinase |
decreases expression |
ISO |
Aspirin results in decreased expression of FER mRNA |
CTD |
PMID:15456535 |
|
NCBI chr 9:103,520,452...103,827,364
Ensembl chr 9:103,520,493...103,821,451
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G |
Fga |
fibrinogen alpha chain |
decreases secretion multiple interactions |
ISO |
Aspirin results in decreased secretion of FGA protein Aspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of FGA protein]; Aspirin promotes the reaction [Adenosine Diphosphate results in increased secretion of FGA protein] |
CTD |
PMID:17303692 |
|
NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528
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G |
Fgb |
fibrinogen beta chain |
multiple interactions decreases secretion |
ISO |
Aspirin inhibits the reaction [Adenosine Diphosphate results in decreased secretion of FGB protein]; Aspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of FGB protein] Aspirin results in decreased secretion of FGB protein |
CTD |
PMID:17303692 |
|
NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979
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G |
Fgg |
fibrinogen gamma chain |
multiple interactions |
ISO |
Aspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of FGG protein]; Aspirin promotes the reaction [Adenosine Diphosphate results in increased secretion of FGG protein] |
CTD |
PMID:17303692 |
|
NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322
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G |
Fgr |
FGR proto-oncogene, Src family tyrosine kinase |
decreases expression |
ISO |
Aspirin results in decreased expression of FGR mRNA |
CTD |
PMID:15928584 |
|
NCBI chr 5:145,189,814...145,219,571
Ensembl chr 5:145,189,841...145,217,326
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G |
Flii |
FLII, actin remodeling protein |
decreases expression |
ISO |
Aspirin results in decreased expression of FLII mRNA |
CTD |
PMID:15928584 |
|
NCBI chr10:45,394,032...45,408,051
Ensembl chr10:45,394,032...45,407,970
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G |
Flot2 |
flotillin 2 |
decreases expression |
ISO |
Aspirin results in decreased expression of FLOT2 mRNA |
CTD |
PMID:15928584 |
|
NCBI chr10:62,926,047...62,947,759
Ensembl chr10:62,920,665...62,947,756
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G |
Fn1 |
fibronectin 1 |
multiple interactions |
EXP |
Aspirin inhibits the reaction [Streptozocin results in increased expression of FN1] |
CTD |
PMID:14586741 |
|
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
increases expression decreases expression |
EXP ISO |
Aspirin results in increased expression of FOS mRNA Aspirin results in decreased expression of FOS mRNA |
CTD |
PMID:12800193 PMID:20457246 |
|
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Fosb |
FosB proto-oncogene, AP-1 transcription factor subunit |
decreases expression |
ISO |
Aspirin results in decreased expression of FOSB mRNA |
CTD |
PMID:15928584 |
|
NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465
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G |
Fosl1 |
FOS like 1, AP-1 transcription factor subunit |
multiple interactions decreases expression increases expression |
ISO EXP |
Aspirin promotes the reaction [FOSL1 protein binds to PLAUR promoter] Aspirin results in decreased expression of FOSL1 mRNA; Aspirin results in decreased expression of FOSL1 protein Aspirin results in increased expression of FOSL1 mRNA |
CTD |
PMID:12800193 PMID:16893520 PMID:21721879 |
|
NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
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G |
Fosl2 |
FOS like 2, AP-1 transcription factor subunit |
increases expression |
EXP |
Aspirin results in increased expression of FOSL2 mRNA |
CTD |
PMID:12800193 |
|
NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034
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G |
Fpr1 |
formyl peptide receptor 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of FPR1 mRNA |
CTD |
PMID:15928584 |
|
NCBI chr 1:58,745,019...58,756,776
Ensembl chr 1:58,747,246...58,756,559
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G |
Fpr2 |
formyl peptide receptor 2 |
increases expression multiple interactions |
ISO |
Aspirin results in increased expression of FPR2 [Aspirin results in increased abundance of lipoxin A4] which results in increased expression of FPR2 |
CTD |
PMID:19597002 |
|
NCBI chr 1:58,776,592...58,785,227
Ensembl chr 1:58,776,752...58,786,019
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G |
Fsip1 |
fibrous sheath interacting protein 1 |
affects response to substance |
ISO |
FSIP1 SNP affects the susceptibility to Aspirin |
CTD |
PMID:20513247 |
|
NCBI chr 3:105,074,584...105,217,180
Ensembl chr 3:105,068,543...105,217,167
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G |
Fst |
follistatin |
affects expression |
EXP |
Aspirin affects the expression of FST mRNA |
CTD |
PMID:12800193 |
|
NCBI chr 2:46,123,260...46,130,584
Ensembl chr 2:46,123,439...46,130,571
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|
G |
Furin |
furin (paired basic amino acid cleaving enzyme) |
decreases expression |
ISO |
Aspirin results in decreased expression of FURIN mRNA |
CTD |
PMID:15928584 |
|
NCBI chr 1:134,348,142...134,361,182
Ensembl chr 1:134,348,144...134,364,314
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G |
Fxr2 |
FMR1 autosomal homolog 2 |
decreases expression |
ISO |
Aspirin results in decreased expression of FXR2 mRNA |
CTD |
PMID:15456535 |
|
NCBI chr10:54,350,577...54,370,964
Ensembl chr10:54,350,131...54,370,964
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G |
G0s2 |
G0/G1switch 2 |
increases expression |
EXP |
Aspirin results in increased expression of G0S2 mRNA |
CTD |
PMID:12800193 |
|
NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451
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G |
G6pc3 |
glucose 6 phosphatase catalytic subunit 3 |
increases expression |
ISO |
Aspirin results in increased expression of G6PC3 mRNA |
CTD |
PMID:11906190 |
|
NCBI chr10:87,146,987...87,151,223
Ensembl chr10:87,146,901...87,151,221
|
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G |
G6pd |
glucose-6-phosphate dehydrogenase |
decreases response to substance decreases activity |
ISO |
G6PD results in decreased susceptibility to Aspirin Aspirin results in decreased activity of G6PD protein mutant form |
CTD |
PMID:5432368 |
|
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
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G |
Gabarap |
GABA type A receptor-associated protein |
decreases expression |
ISO |
Aspirin results in decreased expression of GABARAP mRNA |
CTD |
PMID:15928584 |
|
NCBI chr10:54,714,777...54,718,099
Ensembl chr10:54,714,198...54,717,765
|
|
G |
Gadd45a |
growth arrest and DNA-damage-inducible, alpha |
decreases expression increases expression |
EXP ISO |
Aspirin results in decreased expression of GADD45A mRNA Aspirin results in increased expression of GADD45A mRNA |
CTD |
PMID:12800193 PMID:20514442 |
|
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
|
|
G |
Gas6 |
growth arrest specific 6 |
affects response to substance |
ISO |
GAS6 protein affects the susceptibility to Aspirin |
CTD |
PMID:16999853 |
|
NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904
|
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G |
Gast |
gastrin |
multiple interactions |
EXP |
[lipopolysaccharide, Helicobacter pylori co-treated with Aspirin] results in increased expression of GAST protein |
CTD |
PMID:15024038 |
|
NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496
|
|
G |
Gatd3a |
glutamine amidotransferase class 1 domain containing 3A |
increases expression |
ISO |
Aspirin results in increased expression of GATD3 mRNA |
CTD |
PMID:11906190 |
|
NCBI chr20:10,514,793...10,522,894
Ensembl chr20:10,514,744...10,522,885
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|
G |
Gdf15 |
growth differentiation factor 15 |
increases expression |
ISO |
Aspirin results in increased expression of GDF15 mRNA; Aspirin results in increased expression of GDF15 protein |
CTD |
PMID:14976132 PMID:15180942 |
|
NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055
|
|
G |
Gdnf |
glial cell derived neurotrophic factor |
multiple interactions |
ISO |
Aspirin inhibits the reaction [Benzo(a)pyrene results in decreased expression of GDNF protein] |
CTD |
PMID:37364758 |
|
NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209
|
|
G |
Gfap |
glial fibrillary acidic protein |
decreases expression increases expression |
ISO EXP |
Aspirin results in decreased expression of GFAP mRNA; Aspirin results in decreased expression of GFAP protein Aspirin results in increased expression of GFAP mRNA |
CTD |
PMID:16516312 PMID:21353610 PMID:22954530 |
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NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
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G |
Gfra3 |
GDNF family receptor alpha 3 |
increases expression |
ISO |
Aspirin results in increased expression of GFRA3 mRNA |
CTD |
PMID:15928584 |
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NCBI chr18:26,297,828...26,326,105
Ensembl chr18:26,297,829...26,326,105
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G |
Ggt1 |
gamma-glutamyltransferase 1 |
decreases activity |
EXP |
Aspirin analog results in decreased activity of GGT1 protein |
CTD |
PMID:20171274 |
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NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
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G |
Ghitm |
growth hormone inducible transmembrane protein |
increases expression |
ISO |
Aspirin results in increased expression of GHITM mRNA |
CTD |
PMID:15928584 |
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NCBI chr16:12,885,551...12,897,887
Ensembl chr16:12,885,553...12,897,879
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G |
Gja1 |
gap junction protein, alpha 1 |
decreases expression |
EXP |
Aspirin results in decreased expression of GJA1 mRNA |
CTD |
PMID:12800193 |
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NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
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G |
Gkn1 |
gastrokine 1 |
affects expression |
ISO |
Aspirin affects the expression of GKN1 mRNA; Aspirin affects the expression of GKN1 protein |
CTD |
PMID:19145733 |
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NCBI chr 4:119,790,101...119,795,389
Ensembl chr 4:119,790,101...119,795,389
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G |
Gnb2 |
G protein subunit beta 2 |
decreases expression |
ISO |
Aspirin results in decreased expression of GNB2 mRNA |
CTD |
PMID:15928584 |
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NCBI chr12:19,159,002...19,164,021
Ensembl chr12:19,158,973...19,164,019
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G |
Gp1ba |
glycoprotein Ib platelet subunit alpha |
decreases response to substance increases response to substance affects response to substance |
ISO |
GP1BA SNP results in decreased susceptibility to Aspirin GP1BA polymorphism results in increased susceptibility to Aspirin GP1BA polymorphism affects the susceptibility to Aspirin |
CTD |
PMID:17245331 PMID:17630485 PMID:19250145 |
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NCBI chr10:55,352,938...55,355,804
Ensembl chr10:55,352,899...55,356,774
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G |
Gp6 |
glycoprotein VI |
decreases response to substance |
ISO |
GP6 gene polymorphism results in decreased susceptibility to Aspirin |
CTD |
PMID:16493486 |
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NCBI chr 1:69,429,232...69,492,709
Ensembl chr 1:69,465,789...69,491,326
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions increases expression |
EXP |
fucoidan inhibits the reaction [Aspirin results in increased expression of GPT protein] |
CTD |
PMID:19788892 |
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NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Gpx1 |
glutathione peroxidase 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of GPX1 mRNA |
CTD |
PMID:21353610 |
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NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
decreases phosphorylation increases phosphorylation decreases activity |
ISO EXP |
Aspirin results in decreased phosphorylation of GSK3B protein Aspirin results in increased phosphorylation of GSK3B protein Aspirin results in decreased activity of GSK3B protein |
CTD |
PMID:11593435 PMID:12813129 PMID:19966835 |
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NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
Gsn |
gelsolin |
affects expression |
EXP |
Aspirin affects the expression of GSN protein |
CTD |
PMID:23533533 |
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NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402
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G |
Gsta2 |
glutathione S-transferase alpha 2 |
affects binding |
EXP |
Aspirin binds to GSTA2 protein |
CTD |
PMID:15236443 |
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NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
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G |
Gstm1 |
glutathione S-transferase mu 1 |
affects response to substance |
ISO |
GSTM1 mutant form affects the susceptibility to Aspirin |
CTD |
PMID:16433794 |
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NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
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G |
Gsto1 |
glutathione S-transferase omega 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of GSTO1 mRNA |
CTD |
PMID:14976132 |
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NCBI chr 1:246,721,089...246,731,228
Ensembl chr 1:246,721,221...246,731,468
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G |
Gstt1 |
glutathione S-transferase theta 1 |
increases expression |
EXP |
Aspirin results in increased expression of GSTT1 protein |
CTD |
PMID:9729437 |
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NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585
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G |
Gstt2 |
glutathione S-transferase theta 2 |
increases expression |
EXP |
Aspirin results in increased expression of GSTT2 protein |
CTD |
PMID:9729437 |
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NCBI chr20:12,819,617...12,823,288
Ensembl chr20:12,819,170...12,823,288
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G |
Gtf2i |
general transcription factor II I |
decreases expression |
ISO |
Aspirin results in decreased expression of GTF2I mRNA |
CTD |
PMID:11906190 |
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NCBI chr12:22,400,933...22,476,243
Ensembl chr12:22,401,431...22,476,243
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G |
Gtpbp2 |
GTP binding protein 2 |
decreases expression |
ISO |
Aspirin results in decreased expression of GTPBP2 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 9:14,813,964...14,823,419
Ensembl chr 9:14,813,964...14,823,241
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G |
Guk1 |
guanylate kinase 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of GUK1 mRNA |
CTD |
PMID:15928584 |
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NCBI chr10:43,971,514...43,988,658
Ensembl chr10:43,971,509...43,980,107
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G |
Gzma |
granzyme A |
decreases expression |
ISO |
Aspirin results in decreased expression of GZMA mRNA |
CTD |
PMID:20457246 |
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NCBI chr 2:44,740,569...44,752,502
Ensembl chr 2:44,740,569...44,752,493
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G |
H2ax |
H2A.X variant histone |
decreases expression |
ISO |
Aspirin results in decreased expression of H2AX protein |
CTD |
PMID:23363784 |
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NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 Ensembl chr 4:44,671,786...44,673,239
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G |
Hbegf |
heparin-binding EGF-like growth factor |
multiple interactions increases expression |
EXP |
apple polyphenol extract inhibits the reaction [Aspirin results in increased expression of HBEGF mRNA]; apple polyphenol extract inhibits the reaction [Aspirin results in increased expression of HBEGF protein] Aspirin results in increased expression of HBEGF mRNA; Aspirin results in increased expression of HBEGF protein |
CTD |
PMID:18482463 |
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NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441
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G |
Hck |
HCK proto-oncogene, Src family tyrosine kinase |
decreases expression |
ISO |
Aspirin results in decreased expression of HCK mRNA |
CTD |
PMID:15928584 |
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NCBI chr 3:141,571,587...141,614,696
Ensembl chr 3:141,571,587...141,614,693
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G |
Hcls1 |
hematopoietic cell specific Lyn substrate 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of HCLS1 mRNA |
CTD |
PMID:15928584 |
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NCBI chr11:63,817,482...63,840,943
Ensembl chr11:63,817,476...63,841,014
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G |
Hdac1 |
histone deacetylase 1 |
increases expression |
ISO |
Aspirin results in increased expression of HDAC1 mRNA |
CTD |
PMID:15456535 |
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NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111
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G |
Hdac3 |
histone deacetylase 3 |
multiple interactions |
ISO |
HDAC3 inhibits the reaction [Aspirin results in increased acetylation of and results in increased activity of NOS3 protein]; HDAC3 protein inhibits the reaction [Aspirin promotes the reaction [NOS3 protein binds to CALM1 protein]] |
CTD |
PMID:20705923 |
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NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856
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G |
Hdac4 |
histone deacetylase 4 |
increases expression |
ISO |
Aspirin results in increased expression of HDAC4 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164
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G |
Hdgf |
heparin binding growth factor |
decreases expression |
ISO |
Aspirin results in decreased expression of HDGF mRNA |
CTD |
PMID:15928584 |
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NCBI chr 2:173,370,147...173,379,756
Ensembl chr 2:173,370,465...173,379,747
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G |
Hgf |
hepatocyte growth factor |
multiple interactions |
ISO |
Aspirin inhibits the reaction [HGF results in increased activity of MAPK1 protein]; Aspirin inhibits the reaction [HGF results in increased activity of MAPK3 protein]; Aspirin inhibits the reaction [HGF results in increased expression of MMP9] |
CTD |
PMID:11981761 |
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NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
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G |
Hlcs |
holocarboxylase synthetase |
increases expression |
ISO |
Aspirin results in increased expression of HLCS mRNA |
CTD |
PMID:11906190 |
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NCBI chr11:33,455,806...33,635,197
Ensembl chr11:33,455,809...33,624,222
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G |
Hmgb1 |
high mobility group box 1 |
multiple interactions |
ISO |
Aspirin inhibits the reaction [HMGB1 protein results in increased expression of PTGS2 protein]; Aspirin inhibits the reaction [HMGB1 protein results in increased phosphorylation of MAPK1 protein]; Aspirin inhibits the reaction [HMGB1 protein results in increased phosphorylation of MAPK3 protein]; Aspirin inhibits the reaction [HMGB1 protein results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:34755645 |
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NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565 Ensembl chr16:5,901,586...5,978,565
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G |
Hmmr |
hyaluronan-mediated motility receptor |
increases expression |
ISO |
Aspirin results in increased expression of HMMR mRNA |
CTD |
PMID:11906190 |
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NCBI chr10:25,132,933...25,163,029
Ensembl chr10:25,132,977...25,163,060
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G |
Hmox1 |
heme oxygenase 1 |
increases expression |
ISO EXP |
Aspirin results in increased expression of HMOX1 Aspirin analog results in increased expression of HMOX1 mRNA |
CTD |
PMID:15901601 PMID:19100325 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hnf1a |
HNF1 homeobox A |
decreases expression |
EXP |
Aspirin results in decreased expression of HNF1A mRNA |
CTD |
PMID:12800193 |
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NCBI chr12:41,638,536...41,672,806
Ensembl chr12:41,645,587...41,672,104
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G |
Hnmt |
histamine N-methyltransferase |
affects response to substance |
ISO |
HNMT gene SNP affects the susceptibility to Aspirin |
CTD |
PMID:20485159 |
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NCBI chr 3:6,591,804...6,623,821
Ensembl chr 3:6,591,463...6,624,012
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G |
Hnrnpa1 |
heterogeneous nuclear ribonucleoprotein A1 |
decreases expression |
EXP |
Aspirin results in decreased expression of HNRNPA1 mRNA |
CTD |
PMID:12800193 |
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NCBI chr 7:134,375,318...134,381,610
Ensembl chr 7:134,375,150...134,381,609
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G |
Hnrnpc |
heterogeneous nuclear ribonucleoprotein C |
decreases expression |
EXP |
Aspirin results in decreased expression of HNRNPC mRNA |
CTD |
PMID:12800193 |
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NCBI chr15:24,779,593...24,809,213
Ensembl chr15:24,779,450...24,809,183
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G |
Hnrnpdl |
heterogeneous nuclear ribonucleoprotein D-like |
decreases expression |
ISO |
Aspirin results in decreased expression of HNRNPDL mRNA |
CTD |
PMID:15456535 |
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NCBI chr14:9,557,430...9,563,659
Ensembl chr14:9,557,425...9,562,506
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G |
Hnrnpu |
heterogeneous nuclear ribonucleoprotein U |
increases expression |
ISO |
Aspirin results in increased expression of HNRNPU mRNA |
CTD |
PMID:15928584 |
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NCBI chr13:90,069,058...90,086,905
Ensembl chr13:90,074,181...90,086,588
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G |
Hnrnpul1 |
heterogeneous nuclear ribonucleoprotein U-like 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of HNRNPUL1 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 1:81,228,404...81,264,121
Ensembl chr 1:81,228,404...81,262,592
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G |
Hsf1 |
heat shock transcription factor 1 |
increases activity |
ISO |
Aspirin results in increased activity of HSF1 protein |
CTD |
PMID:10328874 |
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NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
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G |
Hspa1a |
heat shock protein family A (Hsp70) member 1A |
increases expression |
ISO |
Aspirin results in increased expression of HSPA1A mRNA |
CTD |
PMID:15456535 |
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NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
decreases expression |
ISO |
Aspirin results in decreased expression of HSPA5 mRNA |
CTD |
PMID:14976132 |
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NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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G |
Hspb1 |
heat shock protein family B (small) member 1 |
increases expression |
EXP |
Aspirin results in increased expression of HSPB1 mRNA |
CTD |
PMID:12800193 |
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NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
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G |
Iars1 |
isoleucyl-tRNA synthetase 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of IARS1 mRNA |
CTD |
PMID:11906190 |
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NCBI chr17:14,940,919...14,987,277
Ensembl chr17:14,940,924...14,987,237
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G |
Icam1 |
intercellular adhesion molecule 1 |
decreases expression multiple interactions |
ISO EXP |
Aspirin results in decreased expression of ICAM1 mRNA; Aspirin results in decreased expression of ICAM1 protein Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased expression of ICAM1 protein]; Celecoxib inhibits the reaction [Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased expression of ICAM1 protein]] |
CTD |
PMID:14762100 PMID:16310244 PMID:18059344 |
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NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Id2 |
inhibitor of DNA binding 2 |
affects expression |
EXP |
Aspirin affects the expression of ID2 mRNA |
CTD |
PMID:12800193 |
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NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
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G |
Ido1 |
indoleamine 2,3-dioxygenase 1 |
affects response to substance |
ISO |
IDO1 affects the susceptibility to Aspirin |
CTD |
PMID:19489917 |
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NCBI chr16:67,430,654...67,442,726
Ensembl chr16:67,430,578...67,442,730
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G |
Ifi30 |
IFI30, lysosomal thiol reductase |
decreases expression |
ISO |
Aspirin results in decreased expression of IFI30 mRNA |
CTD |
PMID:15928584 |
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NCBI chr16:18,675,590...18,679,655
Ensembl chr16:18,675,613...18,681,175
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G |
Ifng |
interferon gamma |
multiple interactions increases expression |
ISO EXP |
Aspirin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of [IL12A protein binds to IL12B protein]]; Aspirin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased secretion of IFNG protein] Aspirin results in increased expression of IFNG protein fucoidan promotes the reaction [Aspirin results in increased expression of IFNG protein] Aspirin inhibits the reaction [Acetaminophen results in increased expression of IFNG mRNA] |
CTD |
PMID:15379866 PMID:19164858 PMID:19788892 |
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NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Ift27 |
intraflagellar transport 27 |
increases expression |
ISO |
Aspirin results in increased expression of IFT27 mRNA |
CTD |
PMID:11906190 |
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NCBI chr 7:109,738,622...109,754,416
Ensembl chr 7:109,738,622...109,754,416
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G |
Igf2 |
insulin-like growth factor 2 |
decreases expression |
ISO |
Aspirin results in decreased expression of IGF2 mRNA |
CTD |
PMID:9399670 |
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NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018
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G |
Igf2r |
insulin-like growth factor 2 receptor |
increases expression |
ISO |
Aspirin results in increased expression of IGF2R mRNA |
CTD |
PMID:15928584 |
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NCBI chr 1:47,979,109...48,067,501
Ensembl chr 1:47,979,109...48,067,501
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G |
Ikbkb |
inhibitor of nuclear factor kappa B kinase subunit beta |
decreases activity decreases phosphorylation decreases expression |
ISO EXP |
Aspirin results in decreased activity of IKBKB protein Aspirin results in decreased phosphorylation of IKBKB protein Aspirin results in decreased expression of IKBKB protein |
CTD |
PMID:16199534 PMID:16310244 PMID:16880202 |
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NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
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G |
Il10 |
interleukin 10 |
increases response to substance multiple interactions increases expression affects response to substance |
ISO EXP |
IL10 polymorphism results in increased susceptibility to Aspirin fucoidan promotes the reaction [Aspirin results in increased expression of IL10 protein] IL10 polymorphism affects the susceptibility to Aspirin |
CTD |
PMID:16030091 PMID:19222424 PMID:19788892 |
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NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il12a |
interleukin 12A |
multiple interactions |
ISO |
Aspirin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of [IL12A protein binds to IL12B protein]] |
CTD |
PMID:15379866 |
|
NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
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G |
Il12b |
interleukin 12B |
multiple interactions |
ISO |
Aspirin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of [IL12A protein binds to IL12B protein]] |
CTD |
PMID:15379866 |
|
NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
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G |
Il13 |
interleukin 13 |
affects response to substance |
ISO |
IL13 polymorphism affects the susceptibility to Aspirin |
CTD |
PMID:22123380 |
|
NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
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G |
Il17a |
interleukin 17A |
affects response to substance |
ISO |
IL17A polymorphism affects the susceptibility to Aspirin |
CTD |
PMID:22123380 |
|
NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
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G |
Il18 |
interleukin 18 |
multiple interactions affects response to substance |
ISO |
Aspirin inhibits the reaction [Acetaminophen results in increased expression of IL18 mRNA] IL18 polymorphism affects the susceptibility to Aspirin |
CTD |
PMID:19164858 PMID:21692767 |
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NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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G |
Il1a |
interleukin 1 alpha |
multiple interactions increases expression |
ISO |
[Aspirin co-treated with IL1A] results in increased expression of TNF mRNA; Aspirin promotes the reaction [IL1A results in increased expression of CXCL1 mRNA]; Aspirin promotes the reaction [IL1A results in increased expression of IL1B mRNA]; Aspirin promotes the reaction [IL1A results in increased expression of IL6 mRNA]; Aspirin promotes the reaction [IL1A results in increased expression of PTGS2 mRNA]; Aspirin promotes the reaction [IL1A results in increased expression of PTGS2 protein]; Aspirin promotes the reaction [IL1A results in increased phosphorylation of MAPK14 protein]; IL1A promotes the reaction [Aspirin results in increased expression of PTGS2 mRNA]; IL1A promotes the reaction [Aspirin results in increased expression of PTGS2 protein]; IL1A promotes the reaction [Aspirin results in increased phosphorylation of MAPK14 protein] Aspirin results in increased expression of IL1A mRNA |
CTD |
PMID:14742690 PMID:32816093 |
|
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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G |
Il1b |
interleukin 1 beta |
multiple interactions increases expression decreases expression affects response to substance |
ISO EXP |
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid promotes the reaction [Aspirin inhibits the reaction [IL1B results in increased chemical synthesis of Dinoprostone]]; Ascorbic Acid promotes the reaction [Aspirin inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]]; Ascorbic Acid promotes the reaction [Aspirin inhibits the reaction [IL1B results in increased chemical synthesis of Dinoprostone]]; Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]; Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased expression of ICAM1 protein]; Aspirin inhibits the reaction [IL1B results in increased activity of EDNRB]; Aspirin inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; Aspirin inhibits the reaction [IL1B results in increased chemical synthesis of Dinoprostone]; Aspirin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Aspirin promotes the reaction [IL1A results in increased expression of IL1B mRNA]; Celecoxib inhibits the reaction [Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased expression of ICAM1 protein]]; Celecoxib promotes the reaction [Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]]; Naproxen promotes the reaction [Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]]; rofecoxib promotes the reaction [Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]] Ampicillin inhibits the reaction [Aspirin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]]; Ampicillin inhibits the reaction [Aspirin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]]; Aspirin inhibits the reaction [[Lipopolysaccharides co-treated with TNF protein co-treated with IL1B protein] results in increased activity of NFKB1 protein]; Aspirin inhibits the reaction [[Lipopolysaccharides co-treated with TNF protein co-treated with IL1B protein] results in increased activity of RELA protein]; Aspirin inhibits the reaction [Azoxymethane results in increased expression of IL1B mRNA]; Aspirin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of IL1B protein]; Aspirin promotes the reaction [Acetic Acid results in increased expression of IL1B protein]; Aspirin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; Aspirin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]; lipopolysaccharide, Helicobacter pylori inhibits the reaction [Aspirin results in increased expression of IL1B protein] Aspirin results in decreased expression of IL1B mRNA IL1B polymorphism affects the susceptibility to Aspirin Aspirin inhibits the reaction [Acetaminophen results in increased expression of IL1B mRNA]; Aspirin inhibits the reaction [Acetaminophen results in increased expression of IL1B protein]; Aspirin inhibits the reaction [Cisplatin results in increased expression of IL1B mRNA] Aspirin results in increased expression of IL1B mRNA |
CTD |
PMID:11376495 PMID:11826407 PMID:12126971 PMID:14742690 PMID:14762100 PMID:14976132 PMID:15024038 PMID:16529823 PMID:19164858 PMID:20043115 PMID:21353610 PMID:21893697 PMID:22039321 PMID:22132000 PMID:32816093 PMID:36988346 PMID:37179038 More...
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il1r2 |
interleukin 1 receptor type 2 |
affects response to substance |
ISO |
IL1R2 affects the susceptibility to Aspirin |
CTD |
PMID:19489917 |
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NCBI chr 9:42,384,280...42,424,726
Ensembl chr 9:42,384,433...42,424,725
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G |
Il1rn |
interleukin 1 receptor antagonist |
multiple interactions |
ISO |
Aspirin inhibits the reaction [Salmonella Vaccines results in increased expression of IL1RN protein] |
CTD |
PMID:12045164 |
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NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
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G |
Il2 |
interleukin 2 |
multiple interactions |
ISO |
Aspirin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased secretion of IL2 protein] |
CTD |
PMID:15379866 |
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NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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G |
Il24 |
interleukin 24 |
increases expression |
ISO |
Aspirin results in increased expression of IL24 mRNA |
CTD |
PMID:32816093 |
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NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
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G |
Il2rb |
interleukin 2 receptor subunit beta |
increases expression |
ISO |
Aspirin results in increased expression of IL2RB mRNA |
CTD |
PMID:15928584 |
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NCBI chr 7:110,033,341...110,048,054
Ensembl chr 7:110,033,341...110,048,054
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G |
Il2rg |
interleukin 2 receptor subunit gamma |
decreases expression |
ISO |
Aspirin results in decreased expression of IL2RG mRNA |
CTD |
PMID:15928584 |
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NCBI chr X:66,395,330...66,399,026
Ensembl chr X:66,392,542...66,399,823
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G |
Il4 |
interleukin 4 |
multiple interactions decreases secretion decreases expression increases expression |
ISO |
Aspirin inhibits the reaction [IL4 results in increased activity of STAT6 protein]; Aspirin inhibits the reaction [IL4 results in increased expression of CYSLTR1 mRNA]; Aspirin inhibits the reaction [IL4 results in increased expression of FCER1A mRNA]; Aspirin inhibits the reaction [IL4 results in increased phosphorylation of STAT6 protein]; Aspirin promotes the reaction [CEBPB protein binds to IL4 promoter polymorphism] Aspirin results in decreased secretion of IL4 protein Aspirin results in decreased expression of IL4 mRNA Aspirin results in increased expression of IL4 mRNA |
CTD |
PMID:11238116 PMID:19767084 PMID:20921925 |
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NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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G |
Il6 |
interleukin 6 |
multiple interactions increases expression decreases expression |
ISO EXP |
Aspirin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Aspirin promotes the reaction [IL1A results in increased expression of IL6 mRNA]; Aspirin results in decreased expression of and results in decreased secretion of IL6 protein; IL6 protein inhibits the reaction [Aspirin results in decreased expression of STAT3 protein modified form] Aspirin results in increased expression of IL6 protein Aspirin inhibits the reaction [Oxaliplatin results in increased expression of IL6 mRNA]; Aspirin inhibits the reaction [Oxaliplatin results in increased expression of IL6 protein]; fucoidan inhibits the reaction [Aspirin results in increased expression of IL6 protein] Aspirin inhibits the reaction [Cisplatin results in increased expression of IL6 mRNA]; Aspirin inhibits the reaction [Cisplatin results in increased expression of IL6 protein]; Aspirin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] Aspirin results in decreased expression of IL6 protein Aspirin results in decreased expression of IL6 mRNA |
CTD |
PMID:14742690 PMID:15379866 PMID:16413386 PMID:19595669 PMID:19788892 PMID:19896470 PMID:20886344 PMID:35574720 PMID:37179038 More...
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Il6st |
interleukin 6 cytokine family signal transducer |
decreases expression |
ISO |
Aspirin results in decreased expression of IL6ST mRNA |
CTD |
PMID:19595669 |
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NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936
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G |
Il7r |
interleukin 7 receptor |
increases expression |
ISO |
Aspirin results in increased expression of IL7R mRNA |
CTD |
PMID:15928584 |
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NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757
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G |
Ilk |
integrin-linked kinase |
decreases activity decreases expression |
ISO |
Aspirin results in decreased activity of ILK protein Aspirin results in decreased expression of ILK mRNA |
CTD |
PMID:11593435 PMID:15928584 |
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NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140
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G |
Insig1 |
insulin induced gene 1 |
increases expression |
ISO EXP |
Aspirin results in increased expression of INSIG1 mRNA |
CTD |
PMID:12800193 PMID:15928584 |
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NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952
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G |
Iqgap2 |
IQ motif containing GTPase activating protein 2 |
increases expression |
ISO |
Aspirin results in increased expression of IQGAP2 mRNA |
CTD |
PMID:15456535 |
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NCBI chr 2:26,894,836...27,170,270
Ensembl chr 2:26,894,825...27,170,279
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G |
Irf1 |
interferon regulatory factor 1 |
increases expression |
ISO |
Aspirin results in increased expression of IRF1 mRNA |
CTD |
PMID:15928584 |
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NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166
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G |
Irf9 |
interferon regulatory factor 9 |
decreases expression |
ISO |
Aspirin results in decreased expression of IRF9 mRNA |
CTD |
PMID:15928584 |
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NCBI chr15:29,095,474...29,101,924
Ensembl chr15:29,095,789...29,101,236
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G |
Irs1 |
insulin receptor substrate 1 |
affects response to substance |
ISO |
IRS1 polymorphism affects the susceptibility to Aspirin |
CTD |
PMID:15066917 |
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NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
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G |
Itga2 |
integrin subunit alpha 2 |
decreases response to substance multiple interactions |
ISO |
ITGA2 polymorphism results in decreased susceptibility to Aspirin ITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel co-treated with Adenosine Diphosphate]; ITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel co-treated with Epinephrine]; ITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel] |
CTD |
PMID:15205592 PMID:16214444 PMID:18231737 |
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NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481
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Itga2b |
integrin subunit alpha 2b |
decreases expression multiple interactions |
ISO |
Aspirin results in decreased expression of ITGA2B protein Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of ITGA2B protein]; Aspirin results in decreased expression of [ITGA2B protein binds to ITGB2 protein]; Aspirin results in decreased expression of [ITGA2B protein binds to ITGB3 protein]; Glucose inhibits the reaction [Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of ITGA2B protein]] |
CTD |
PMID:15140583 PMID:15381054 PMID:18413191 |
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NCBI chr10:87,408,532...87,426,055
Ensembl chr10:87,408,536...87,426,168
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G |
Itga5 |
integrin subunit alpha 5 |
decreases expression |
ISO |
Aspirin results in decreased expression of ITGA5 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 7:134,478,963...134,502,837
Ensembl chr 7:134,478,968...134,502,837
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G |
Itgb2 |
integrin subunit beta 2 |
multiple interactions |
ISO |
Aspirin results in decreased expression of [ITGA2B protein binds to ITGB2 protein] |
CTD |
PMID:15140583 |
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NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600
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G |
Itgb3 |
integrin subunit beta 3 |
multiple interactions increases expression decreases response to substance affects response to substance |
ISO |
Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of ITGB3 protein]; Aspirin results in decreased expression of [ITGA2B protein binds to ITGB3 protein]; Glucose inhibits the reaction [Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of ITGB3 protein]]; ITGB3 polymorphism affects the reaction [Aspirin affects the cleavage of F2 protein] Aspirin results in increased expression of ITGB3 mRNA; Aspirin results in increased expression of ITGB3 protein ITGB3 gene polymorphism results in decreased susceptibility to Aspirin; ITGB3 polymorphism results in decreased susceptibility to Aspirin; ITGB3 results in decreased susceptibility to Aspirin ITGB3 gene polymorphism affects the susceptibility to Aspirin |
CTD |
PMID:13678940 PMID:15381054 PMID:15840736 PMID:16153930 PMID:16675000 PMID:17184645 PMID:18413191 PMID:21035850 More...
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NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
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G |
Itgb4 |
integrin subunit beta 4 |
decreases expression |
ISO |
Aspirin results in decreased expression of ITGB4 mRNA |
CTD |
PMID:14976132 |
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NCBI chr10:101,206,657...101,243,012
Ensembl chr10:101,206,665...101,243,012
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions increases expression |
ISO |
Aspirin inhibits the reaction [Glucose results in increased expression of JUN protein]; Aspirin promotes the reaction [JUN protein binds to PLAUR promoter] Aspirin results in increased expression of JUN mRNA |
CTD |
PMID:14976132 PMID:16600694 PMID:16893520 PMID:20457246 |
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NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Junb |
JunB proto-oncogene, AP-1 transcription factor subunit |
increases expression |
EXP |
Aspirin results in increased expression of JUNB mRNA |
CTD |
PMID:12800193 |
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NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
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G |
Jund |
JunD proto-oncogene, AP-1 transcription factor subunit |
decreases expression |
ISO |
Aspirin results in decreased expression of JUND mRNA |
CTD |
PMID:14976132 |
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NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799
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G |
Kat7 |
lysine acetyltransferase 7 |
decreases expression |
ISO |
Aspirin results in decreased expression of KAT7 mRNA |
CTD |
PMID:15928584 |
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NCBI chr10:80,221,519...80,255,590
Ensembl chr10:80,221,524...80,255,567
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G |
Kcnmb4 |
potassium calcium-activated channel subfamily M regulatory beta subunit 4 |
decreases expression |
ISO |
Aspirin results in decreased expression of KCNMB4 mRNA |
CTD |
PMID:11906190 |
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NCBI chr 7:52,066,145...52,119,098
Ensembl chr 7:52,066,136...52,119,278
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G |
Kctd13 |
potassium channel tetramerization domain containing 13 |
increases expression |
EXP |
Aspirin results in increased expression of KCTD13 mRNA |
CTD |
PMID:12800193 |
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NCBI chr 1:181,534,534...181,552,843
Ensembl chr 1:181,534,515...181,552,881
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G |
Kdm5b |
lysine demethylase 5B |
decreases expression |
ISO |
Aspirin results in decreased expression of KDM5B mRNA |
CTD |
PMID:15928584 |
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NCBI chr13:46,001,589...46,073,868
Ensembl chr13:46,002,542...46,073,872
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G |
Kif20b |
kinesin family member 20B |
decreases expression |
ISO |
Aspirin results in decreased expression of KIF20B mRNA |
CTD |
PMID:11906190 |
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NCBI chr 1:232,428,293...232,483,798
Ensembl chr 1:232,428,371...232,483,787
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G |
Kif21a |
kinesin family member 21A |
increases expression |
ISO |
Aspirin results in increased expression of KIF21A mRNA |
CTD |
PMID:11906190 |
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NCBI chr 7:122,062,523...122,179,051
Ensembl chr 7:122,062,537...122,178,999
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G |
Kif3a |
kinesin family member 3a |
increases expression affects response to substance |
ISO |
Aspirin results in increased expression of KIF3A mRNA KIF3A polymorphism affects the susceptibility to Aspirin |
CTD |
PMID:20922562 |
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NCBI chr10:37,725,930...37,761,183
Ensembl chr10:37,725,970...37,759,191
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G |
Klrb1a |
killer cell lectin like receptor B1A |
increases expression |
ISO |
Aspirin results in increased expression of KLRB1 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 4:161,890,577...161,904,050
Ensembl chr 4:161,890,577...161,961,675
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G |
Kng1 |
kininogen 1 |
decreases activity |
EXP |
Aspirin results in decreased activity of KNG1 |
CTD |
PMID:1334751 |
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NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555
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G |
Kpna3 |
karyopherin subunit alpha 3 |
increases expression |
ISO |
Aspirin results in increased expression of KPNA3 mRNA |
CTD |
PMID:15928584 |
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NCBI chr15:35,536,310...35,610,066
Ensembl chr15:35,536,316...35,610,419
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G |
Lck |
LCK proto-oncogene, Src family tyrosine kinase |
decreases expression |
ISO |
Aspirin results in decreased expression of LCK mRNA |
CTD |
PMID:15928584 |
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NCBI chr 5:141,888,318...141,916,945
Ensembl chr 5:141,888,326...141,903,794
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G |
Lcn2 |
lipocalin 2 |
multiple interactions |
EXP |
Aspirin inhibits the reaction [Azoxymethane results in decreased expression of LCN2 mRNA] |
CTD |
PMID:20043115 |
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NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
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G |
Lct |
lactase |
multiple interactions increases activity decreases activity |
EXP |
[Aspirin results in decreased activity of LCT protein] which results in decreased transport of Glucose Aspirin results in increased activity of LCT; Aspirin results in increased activity of LCT protein |
CTD |
PMID:16382204 PMID:16855794 PMID:17147060 PMID:18604318 |
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NCBI chr13:39,781,929...39,824,456
Ensembl chr13:39,781,929...39,824,456
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G |
Ldlr |
low density lipoprotein receptor |
multiple interactions |
ISO |
Aspirin inhibits the reaction [LDLR gene mutant form results in decreased susceptibility to Arachidonic Acid] Aspirin inhibits the reaction [LDLR gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]]; Aspirin promotes the reaction [[Cholesterol, LDL binds to LDLR protein] which results in increased degradation of Cholesterol, LDL]; Aspirin promotes the reaction [Cholesterol, LDL binds to LDLR protein] |
CTD |
PMID:10395027 PMID:20530721 |
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NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
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G |
Lep |
leptin |
multiple interactions |
EXP |
[lipopolysaccharide, Helicobacter pylori co-treated with Aspirin] results in increased expression of LEP protein |
CTD |
PMID:15024038 |
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NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
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G |
Lif |
LIF, interleukin 6 family cytokine |
increases expression |
ISO |
Aspirin results in increased expression of LIF mRNA; Aspirin results in increased expression of LIF protein |
CTD |
PMID:21035850 |
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NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482
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G |
Lmna |
lamin A/C |
multiple interactions |
ISO |
Aspirin inhibits the reaction [Deoxycholic Acid results in increased cleavage of LMNA protein] |
CTD |
PMID:17644113 |
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NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423
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G |
Lmo7 |
LIM domain 7 |
increases expression |
ISO |
Aspirin results in increased expression of LMO7 mRNA |
CTD |
PMID:15456535 |
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NCBI chr15:78,566,999...78,769,833
Ensembl chr15:78,567,023...78,769,783
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G |
Lta |
lymphotoxin alpha |
affects response to substance |
ISO |
LTA gene SNP affects the susceptibility to Aspirin |
CTD |
PMID:16931544 |
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NCBI chr20:3,618,853...3,621,324
Ensembl chr20:3,618,853...3,620,859
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G |
Ltc4s |
leukotriene C4 synthase |
affects response to substance |
ISO |
LTC4S affects the susceptibility to Aspirin; LTC4S gene SNP affects the susceptibility to Aspirin; LTC4S polymorphism affects the susceptibility to Aspirin |
CTD |
PMID:15100686 PMID:16433794 PMID:19767084 PMID:19862937 PMID:20485159 |
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NCBI chr10:34,560,476...34,562,790
Ensembl chr10:34,560,360...34,562,651
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G |
Ly9 |
lymphocyte antigen 9 |
increases expression |
ISO |
Aspirin results in increased expression of LY9 mRNA |
CTD |
PMID:11906190 |
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NCBI chr13:84,079,345...84,100,783
Ensembl chr13:84,079,458...84,100,823
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G |
Lyn |
LYN proto-oncogene, Src family tyrosine kinase |
increases expression |
ISO |
Aspirin results in increased expression of LYN mRNA |
CTD |
PMID:15928584 |
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NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868
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G |
Madd |
MAP-kinase activating death domain |
decreases expression |
ISO |
Aspirin results in decreased expression of MADD mRNA |
CTD |
PMID:15928584 |
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NCBI chr 3:77,114,330...77,157,865
Ensembl chr 3:77,114,314...77,157,701
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G |
Map2k1 |
mitogen activated protein kinase kinase 1 |
increases expression |
ISO |
Aspirin results in increased expression of MAP2K1 mRNA |
CTD |
PMID:20457246 |
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NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
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G |
Map2k2 |
mitogen activated protein kinase kinase 2 |
decreases expression |
ISO |
Aspirin results in decreased expression of MAP2K2 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243
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G |
Map2k5 |
mitogen activated protein kinase kinase 5 |
decreases expression |
ISO |
Aspirin results in decreased expression of MAP2K5 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 8:63,625,220...63,852,090
Ensembl chr 8:63,625,221...63,851,983
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G |
Map4k4 |
mitogen-activated protein kinase kinase kinase kinase 4 |
decreases expression |
ISO |
Aspirin results in decreased expression of MAP4K4 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 9:42,200,708...42,326,708
Ensembl chr 9:42,200,278...42,326,698
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions increases activity decreases expression |
ISO |
Aspirin inhibits the reaction [HGF results in increased activity of MAPK1 protein]; Aspirin inhibits the reaction [HMGB1 protein results in increased phosphorylation of MAPK1 protein]; Aspirin results in decreased phosphorylation of and results in decreased activity of MAPK1 protein Aspirin results in increased activity of MAPK1 protein Aspirin results in decreased expression of MAPK1 protein modified form |
CTD |
PMID:10993886 PMID:11981761 PMID:15447849 PMID:20116423 PMID:21617849 PMID:34755645 More...
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk12 |
mitogen-activated protein kinase 12 |
decreases expression |
ISO |
Aspirin results in decreased expression of MAPK12 mRNA |
CTD |
PMID:20514442 |
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NCBI chr 7:120,206,005...120,216,711
Ensembl chr 7:120,206,271...120,216,664
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G |
Mapk14 |
mitogen activated protein kinase 14 |
multiple interactions increases phosphorylation |
ISO |
Aspirin promotes the reaction [IL1A results in increased phosphorylation of MAPK14 protein]; IL1A promotes the reaction [Aspirin results in increased phosphorylation of MAPK14 protein] |
CTD |
PMID:14742690 |
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NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions decreases expression increases activity |
ISO |
Aspirin inhibits the reaction [HGF results in increased activity of MAPK3 protein]; Aspirin inhibits the reaction [HMGB1 protein results in increased phosphorylation of MAPK3 protein]; Aspirin results in decreased phosphorylation of and results in decreased activity of MAPK3 protein Aspirin results in decreased expression of MAPK3 protein modified form Aspirin results in increased activity of MAPK3 protein |
CTD |
PMID:10993886 PMID:11981761 PMID:15447849 PMID:20116423 PMID:21617849 PMID:34755645 More...
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Mapkapk3 |
MAPK activated protein kinase 3 |
decreases expression |
ISO |
Aspirin results in decreased expression of MAPKAPK3 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 8:107,929,754...107,963,638
Ensembl chr 8:107,929,762...107,963,568
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Mcam |
melanoma cell adhesion molecule |
increases expression |
ISO |
Aspirin results in increased expression of MCAM mRNA |
CTD |
PMID:15456535 |
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NCBI chr 8:44,479,391...44,487,575
Ensembl chr 8:44,479,376...44,487,571
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Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
decreases expression multiple interactions |
ISO |
Aspirin results in decreased expression of MCL1 protein Aspirin results in increased degradation of and results in decreased expression of MCL1 protein |
CTD |
PMID:19936928 PMID:20116423 |
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NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
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Mcm5 |
minichromosome maintenance complex component 5 |
decreases expression |
EXP |
Aspirin results in decreased expression of MCM5 mRNA |
CTD |
PMID:12800193 |
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NCBI chr19:13,483,030...13,504,389
Ensembl chr19:13,483,066...13,504,389
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Mcm6 |
minichromosome maintenance complex component 6 |
decreases expression |
EXP |
Aspirin results in decreased expression of MCM6 mRNA |
CTD |
PMID:12800193 |
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NCBI chr13:39,826,745...39,851,937
Ensembl chr13:39,826,763...39,851,960
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Mdm2 |
MDM2 proto-oncogene |
decreases expression |
ISO |
Aspirin results in decreased expression of MDM2 mRNA |
CTD |
PMID:20457246 |
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NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
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Med4 |
mediator complex subunit 4 |
increases expression |
ISO |
Aspirin results in increased expression of MED4 mRNA |
CTD |
PMID:15928584 |
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NCBI chr15:48,696,542...48,706,818
Ensembl chr15:48,696,511...48,706,820
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Met |
MET proto-oncogene, receptor tyrosine kinase |
decreases expression increases expression multiple interactions |
ISO |
Aspirin results in decreased expression of CMET protein Aspirin results in increased expression of MET mRNA CTNNB1 affects the reaction [Aspirin results in decreased expression of CMET protein] |
CTD |
PMID:16878161 PMID:32816093 |
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NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
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Mir1306 |
microRNA 1306 |
multiple interactions |
ISO |
Aspirin inhibits the reaction [Benzo(a)pyrene results in decreased expression of MIR1306 mRNA] |
CTD |
PMID:37364758 |
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NCBI chr11:82,709,651...82,709,723
Ensembl chr11:82,709,637...82,709,719
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G |
Mir26b |
microRNA 26b |
multiple interactions |
ISO |
Aspirin inhibits the reaction [Benzo(a)pyrene results in decreased expression of MIR26B mRNA] |
CTD |
PMID:37364758 |
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NCBI chr 9:75,976,596...75,976,680
Ensembl chr 9:75,976,596...75,976,680
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G |
Mki67 |
marker of proliferation Ki-67 |
multiple interactions |
EXP |
Aspirin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MKI67 protein] |
CTD |
PMID:29031619 |
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NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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G |
Mlf2 |
myeloid leukemia factor 2 |
decreases expression |
ISO |
Aspirin results in decreased expression of MLF2 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 4:157,739,651...157,744,325
Ensembl chr 4:157,728,756...157,744,317
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G |
Mmp13 |
matrix metallopeptidase 13 |
increases expression multiple interactions |
EXP |
Aspirin results in increased expression of MMP13 mRNA [Aspirin co-treated with Carbon Tetrachloride] results in increased expression of and results in increased cleavage of MMP13 protein |
CTD |
PMID:12800193 PMID:21360558 |
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NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
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Mmp2 |
matrix metallopeptidase 2 |
decreases expression multiple interactions decreases secretion |
ISO EXP |
Aspirin results in decreased expression of MMP2 [Aspirin co-treated with Carbon Tetrachloride] results in increased expression of MMP2 protein Aspirin results in decreased secretion of MMP2 protein Aspirin results in decreased expression of MMP2 mRNA |
CTD |
PMID:18971601 PMID:19462226 PMID:21360558 |
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NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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Mmp3 |
matrix metallopeptidase 3 |
multiple interactions |
EXP |
Aspirin inhibits the reaction [Azoxymethane results in increased expression of MMP3 mRNA] |
CTD |
PMID:20043115 |
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NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
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G |
Mmp7 |
matrix metallopeptidase 7 |
decreases expression multiple interactions |
EXP |
Aspirin results in decreased expression of MMP7 mRNA Aspirin inhibits the reaction [Azoxymethane results in increased expression of MMP7 mRNA] |
CTD |
PMID:12800193 PMID:20043115 |
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NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902
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Mmp9 |
matrix metallopeptidase 9 |
multiple interactions decreases secretion decreases expression decreases activity |
ISO EXP |
Aspirin inhibits the reaction [HGF results in increased expression of MMP9] Aspirin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MMP9 protein] Aspirin results in decreased secretion of MMP9 protein Aspirin results in decreased expression of MMP9 mRNA Aspirin results in decreased expression of MMP9; Aspirin results in decreased expression of MMP9 mRNA Aspirin results in decreased activity of MMP9 protein |
CTD |
PMID:11981761 PMID:15928584 PMID:18971601 PMID:19462226 PMID:19880272 PMID:20137092 PMID:29031619 More...
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NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Mob2 |
MOB kinase activator 2 |
increases expression |
ISO |
Aspirin results in increased expression of MOB2 mRNA |
CTD |
PMID:15456535 |
|
NCBI chr 1:197,092,991...197,149,978
Ensembl chr 1:197,092,994...197,149,933
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G |
Mpo |
myeloperoxidase |
multiple interactions increases expression |
EXP |
Aspirin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]; Bee Venoms inhibits the reaction [Aspirin results in increased expression of MPO protein]; Ranitidine inhibits the reaction [Aspirin results in increased expression of MPO protein] |
CTD |
PMID:21893697 PMID:22039321 PMID:30885738 |
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NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Mpzl1 |
myelin protein zero-like 1 |
increases expression |
EXP |
Aspirin results in increased expression of MPZL1 mRNA |
CTD |
PMID:12800193 |
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NCBI chr13:77,852,467...77,889,305
Ensembl chr13:77,852,467...77,896,616
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G |
Mrpl46 |
mitochondrial ribosomal protein L46 |
increases expression |
ISO |
Aspirin results in increased expression of MRPL46 mRNA |
CTD |
PMID:15928584 |
|
NCBI chr 1:132,698,872...132,707,639
Ensembl chr 1:132,698,601...132,707,628
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G |
Ms4a2 |
membrane spanning 4-domains A2 |
affects response to substance |
ISO |
MS4A2 polymorphism affects the susceptibility to Aspirin; MS4A2 SNP affects the susceptibility to Aspirin |
CTD |
PMID:16839402 PMID:18379861 PMID:18534082 |
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NCBI chr 1:208,440,179...208,448,716
Ensembl chr 1:208,440,361...208,448,310
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G |
Mt-co1 |
mitochondrially encoded cytochrome c oxidase I |
increases expression |
EXP |
Aspirin results in increased expression of COX1 mRNA |
CTD |
PMID:8554334 |
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NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
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Mt-nd1 |
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 |
increases expression multiple interactions |
EXP ISO |
Aspirin results in increased expression of ND1 mRNA Aspirin inhibits the reaction [Cisplatin results in decreased expression of ND1 mRNA] |
CTD |
PMID:8554334 PMID:37179038 |
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NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694
Ensembl chr MT:2,740...3,694
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Mt-nd3 |
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3 |
multiple interactions |
ISO |
Aspirin inhibits the reaction [Cisplatin results in decreased expression of ND3 mRNA] |
CTD |
PMID:37179038 |
|
NCBI chr MT:9,451...9,798 NCBI chr MT:9,451...9,798 NCBI chr MT:9,451...9,798 NCBI chr MT:9,451...9,798 NCBI chr MT:9,451...9,798 NCBI chr MT:9,451...9,798 NCBI chr MT:9,451...9,798 NCBI chr MT:9,451...9,798 NCBI chr MT:9,451...9,798 NCBI chr MT:9,451...9,798 NCBI chr MT:9,451...9,798
Ensembl chr MT:9,451...9,798
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Mt1 |
metallothionein 1 |
increases expression multiple interactions |
EXP ISO |
Aspirin results in increased expression of MT1A mRNA Aspirin inhibits the reaction [Copper results in increased activity of MT1 promoter] |
CTD |
PMID:12800193 PMID:14576086 |
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NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049 Ensembl chr17:10,826,032...10,827,049 Ensembl chr X:10,826,032...10,827,049
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Mta1 |
metastasis associated 1 |
increases expression |
ISO |
Aspirin results in increased expression of MTA1 mRNA |
CTD |
PMID:15456535 |
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NCBI chr 6:132,178,608...132,217,641
Ensembl chr 6:132,178,853...132,217,641
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G |
Mtor |
mechanistic target of rapamycin kinase |
multiple interactions |
ISO |
Aspirin results in decreased phosphorylation of and results in increased expression of MTOR protein |
CTD |
PMID:23363784 |
|
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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G |
Mttp |
microsomal triglyceride transfer protein |
decreases expression |
ISO |
Aspirin results in decreased expression of MTTP mRNA |
CTD |
PMID:27089845 |
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NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239
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G |
Mx1 |
MX dynamin like GTPase 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of MX1 mRNA |
CTD |
PMID:15928584 |
|
NCBI chr11:36,799,659...36,825,209
Ensembl chr11:36,799,660...36,823,507
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G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
decreases expression increases expression multiple interactions |
EXP ISO |
Aspirin results in decreased expression of MYC mRNA Aspirin results in decreased expression of MYC mRNA; Aspirin results in decreased expression of MYC protein Aspirin results in increased expression of MYC mRNA CTNNB1 affects the reaction [Aspirin results in decreased expression of MYC protein] |
CTD |
PMID:11906190 PMID:12800193 PMID:16878161 PMID:20457246 PMID:21721879 |
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NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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G |
Naa15 |
N(alpha)-acetyltransferase 15, NatA auxiliary subunit |
decreases expression |
EXP |
Aspirin results in decreased expression of NAA15 mRNA |
CTD |
PMID:12800193 |
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NCBI chr 2:135,458,018...135,520,756
Ensembl chr 2:135,457,948...135,520,756
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G |
Naa38 |
N(alpha)-acetyltransferase 38, NatC auxiliary subunit |
increases expression |
ISO |
Aspirin results in increased expression of NAA38 mRNA |
CTD |
PMID:15456535 |
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NCBI chr10:54,117,754...54,118,913
Ensembl chr10:54,117,163...54,119,494
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G |
Nat1 |
N-acetyltransferase 1 |
decreases activity |
EXP |
Aspirin results in decreased activity of NAT1 protein |
CTD |
PMID:15796213 |
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NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520
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G |
Nat2 |
N-acetyltransferase 2 |
affects response to substance |
ISO |
NAT2 polymorphism affects the susceptibility to Aspirin |
CTD |
PMID:20602614 |
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NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
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G |
Ncf1 |
neutrophil cytosolic factor 1 |
multiple interactions decreases expression |
ISO |
Aspirin inhibits the reaction [Hydrogen Peroxide results in increased expression of NCF1 mRNA] Aspirin results in decreased expression of NCF1 mRNA |
CTD |
PMID:21353610 PMID:22306536 |
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NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
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Ndst2 |
N-deacetylase and N-sulfotransferase 2 |
increases expression |
ISO |
Aspirin results in increased expression of NDST2 mRNA |
CTD |
PMID:11906190 |
|
NCBI chr15:3,563,515...3,573,801
Ensembl chr15:3,563,358...3,573,801
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G |
Ndufs4 |
NADH:ubiquinone oxidoreductase subunit S4 |
multiple interactions |
ISO |
Aspirin inhibits the reaction [Cisplatin results in decreased expression of NDUFS4 mRNA] |
CTD |
PMID:37179038 |
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NCBI chr 2:45,951,327...46,061,829
Ensembl chr 2:45,951,313...46,061,846
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions decreases expression decreases localization increases activity |
ISO EXP |
Aspirin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Aspirin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Aspirin promotes the reaction [NFKB1 protein binds to SAT1 promoter] Aspirin results in decreased expression of NFKB1 mRNA Aspirin results in decreased localization of NFKB1 protein Aspirin inhibits the reaction [[Lipopolysaccharides co-treated with TNF protein co-treated with IL1B protein] results in increased activity of NFKB1 protein] [Pertussis Toxin co-treated with Dithiothreitol] inhibits the reaction [Aspirin inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]]; Aspirin inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]] Aspirin results in increased activity of NFKB1 protein |
CTD |
PMID:9281604 PMID:11826407 PMID:14976132 PMID:15489888 PMID:16262603 PMID:17259377 PMID:20457246 More...
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NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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Nfkbia |
NFKB inhibitor alpha |
multiple interactions decreases expression decreases degradation increases expression increases degradation |
ISO EXP |
Aspirin inhibits the reaction [HMGB1 protein results in increased phosphorylation of NFKBIA protein]; Aspirin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; Aspirin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]; Aspirin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Aspirin inhibits the reaction [TNF results in increased degradation of NFKBIA protein]; Aspirin inhibits the reaction [TNF results in increased phosphorylation of NFKBIA protein]; Aspirin results in decreased phosphorylation of and results in increased expression of NFKBIA protein Aspirin results in decreased expression of NFKBIA mRNA Aspirin results in decreased degradation of NFKBIA protein Aspirin results in increased expression of NFKBIA protein Aspirin results in increased degradation of NFKBIA protein |
CTD |
PMID:14753751 PMID:15036249 PMID:15188000 PMID:15489888 PMID:15770215 PMID:16199534 PMID:16310244 PMID:16880202 PMID:16936242 PMID:20457246 PMID:34755645 More...
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nfkbib |
NFKB inhibitor beta |
multiple interactions |
ISO |
Aspirin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased degradation of NFKBIB protein]; Aspirin inhibits the reaction [TNF results in increased phosphorylation of NFKBIB protein] |
CTD |
PMID:14753751 PMID:15036249 |
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NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862
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G |
Nfkbiz |
NFKB inhibitor zeta |
increases expression |
ISO |
Aspirin results in increased expression of NFKBIZ mRNA |
CTD |
PMID:15928584 |
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NCBI chr11:44,782,676...44,810,722
Ensembl chr11:44,782,676...44,810,723
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Ngfr |
nerve growth factor receptor |
increases expression |
ISO |
Aspirin analog results in increased expression of NGFR protein |
CTD |
PMID:17447067 |
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NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
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Ninj1 |
ninjurin 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of NINJ1 mRNA |
CTD |
PMID:15928584 |
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NCBI chr17:15,452,804...15,461,684
Ensembl chr17:15,452,813...15,461,704
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Nkg7 |
natural killer cell granule protein 7 |
decreases expression |
ISO |
Aspirin results in decreased expression of NKG7 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 1:93,844,748...93,845,975
Ensembl chr 1:93,844,902...93,845,983
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Nkx2-1 |
NK2 homeobox 1 |
affects expression |
EXP |
Aspirin affects the expression of NKX2-1 mRNA |
CTD |
PMID:12800193 |
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NCBI chr 6:73,996,601...74,001,483
Ensembl chr 6:73,996,601...73,999,791
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G |
Nlrp3 |
NLR family, pyrin domain containing 3 |
affects response to substance |
ISO |
NLRP3 SNP affects the susceptibility to Aspirin |
CTD |
PMID:19767079 |
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NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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G |
Nme6 |
NME/NM23 nucleoside diphosphate kinase 6 |
increases expression |
ISO |
Aspirin results in increased expression of NME6 mRNA |
CTD |
PMID:15456535 |
|
NCBI chr 8:109,832,085...109,839,301
Ensembl chr 8:109,832,589...109,839,301
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Nolc1 |
nucleolar and coiled-body phosphoprotein 1 |
decreases expression |
EXP |
Aspirin results in decreased expression of NOLC1 mRNA |
CTD |
PMID:12800193 |
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NCBI chr 1:244,921,275...244,932,089
Ensembl chr 1:244,921,377...244,932,088
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Nos2 |
nitric oxide synthase 2 |
multiple interactions decreases expression increases expression |
ISO EXP |
Ascorbic Acid inhibits the reaction [Aspirin results in increased expression of NOS2 protein] [Aspirin results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide Ampicillin inhibits the reaction [Aspirin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 mRNA]]; Aspirin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 mRNA] |
CTD |
PMID:10860828 PMID:16310244 PMID:17218764 PMID:21893697 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nos3 |
nitric oxide synthase 3 |
multiple interactions |
ISO |
Aspirin inhibits the reaction [Everolimus results in decreased expression of NOS3 protein]; Aspirin inhibits the reaction [Paclitaxel results in decreased expression of NOS3 protein]; Aspirin inhibits the reaction [Sirolimus results in decreased expression of NOS3 protein]; Aspirin promotes the reaction [NOS3 protein binds to CALM1 protein]; Aspirin results in increased acetylation of and results in increased activity of NOS3 protein; HDAC3 inhibits the reaction [Aspirin results in increased acetylation of and results in increased activity of NOS3 protein]; HDAC3 protein inhibits the reaction [Aspirin promotes the reaction [NOS3 protein binds to CALM1 protein]] |
CTD |
PMID:19520256 PMID:20705923 |
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NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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Npepps |
aminopeptidase puromycin sensitive |
decreases expression |
ISO |
Aspirin results in decreased expression of NPEPPS mRNA |
CTD |
PMID:11906190 |
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NCBI chr10:82,191,454...82,273,967
Ensembl chr10:82,191,456...82,273,967
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Nppb |
natriuretic peptide B |
affects expression multiple interactions increases expression |
EXP ISO |
Aspirin affects the expression of NPPB mRNA [carvedilol co-treated with temocapril hydrochloride co-treated with Spironolactone co-treated with Aspirin] affects the expression of NPPB protein Aspirin results in increased expression of NPPB mRNA |
CTD |
PMID:12800193 PMID:21378469 |
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NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
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G |
Npr1 |
natriuretic peptide receptor 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of NPR1 mRNA |
CTD |
PMID:11906190 |
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NCBI chr 2:175,934,181...175,950,118
Ensembl chr 2:175,934,181...175,949,505
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions increases activity |
ISO |
Acetylcysteine inhibits the reaction [Aspirin analog results in increased activity of NQO1 protein] |
CTD |
PMID:23035985 |
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NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Nr4a3 |
nuclear receptor subfamily 4, group A, member 3 |
increases expression |
ISO |
Aspirin results in increased expression of NR4A3 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733
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G |
Nrcam |
neuronal cell adhesion molecule |
decreases expression |
ISO |
Aspirin results in decreased expression of NRCAM mRNA |
CTD |
PMID:15456535 |
|
NCBI chr 6:61,402,813...61,698,536
Ensembl chr 6:61,329,863...61,702,992
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G |
Nrf1 |
nuclear respiratory factor 1 |
multiple interactions |
ISO |
Aspirin inhibits the reaction [Cisplatin results in decreased expression of NRF1 protein] |
CTD |
PMID:37179038 |
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NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328
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G |
Nubp2 |
NUBP iron-sulfur cluster assembly factor 2 |
decreases expression |
ISO |
Aspirin results in decreased expression of NUBP2 mRNA |
CTD |
PMID:15456535 PMID:15928584 |
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NCBI chr10:13,903,224...13,906,928
Ensembl chr10:13,903,224...13,906,969
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G |
Oas1a |
2'-5' oligoadenylate synthetase 1A |
increases expression |
ISO |
Aspirin results in increased expression of OAS1 mRNA |
CTD |
PMID:14976132 |
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NCBI chr12:35,669,798...35,680,505
Ensembl chr12:35,669,801...35,680,517
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G |
Odc1 |
ornithine decarboxylase 1 |
increases expression increases response to substance |
ISO |
Aspirin results in increased expression of ODC1 mRNA ODC1 polymorphism results in increased susceptibility to Aspirin |
CTD |
PMID:14976132 PMID:18413818 |
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NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
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G |
Orc4 |
origin recognition complex, subunit 4 |
increases expression |
ISO |
Aspirin results in increased expression of ORC4 mRNA |
CTD |
PMID:11906190 |
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NCBI chr 3:33,290,844...33,334,022
Ensembl chr 3:33,294,355...33,333,824
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G |
Osm |
oncostatin M |
multiple interactions |
ISO |
Aspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of OSM protein] |
CTD |
PMID:17303692 |
|
NCBI chr14:79,103,638...79,108,500
Ensembl chr14:79,104,344...79,108,313
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G |
Osr1 |
odd-skipped related transcription factor 1 |
increases expression |
ISO |
Aspirin results in increased expression of OSR1 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 6:32,369,561...32,380,822
Ensembl chr 6:32,373,816...32,380,817
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G |
Otc |
ornithine transcarbamylase |
decreases expression |
ISO |
Aspirin results in decreased expression of OTC protein |
CTD |
PMID:8295421 |
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NCBI chr X:12,453,834...12,529,954
Ensembl chr X:12,453,834...12,566,918
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G |
P2ry1 |
purinergic receptor P2Y1 |
decreases response to substance affects response to substance |
ISO |
P2RY1 polymorphism results in decreased susceptibility to Aspirin; P2RY1 SNP results in decreased susceptibility to Aspirin P2RY1 affects the susceptibility to Aspirin |
CTD |
PMID:15757620 PMID:17559347 PMID:21429568 |
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NCBI chr 2:145,241,975...145,248,186
Ensembl chr 2:145,241,849...145,248,457
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G |
P2ry12 |
purinergic receptor P2Y12 |
affects response to substance |
ISO |
P2RY12 affects the susceptibility to Aspirin |
CTD |
PMID:14597584 |
|
NCBI chr 2:143,481,468...143,523,340
Ensembl chr 2:143,481,430...143,523,361
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G |
Pag1 |
phosphoprotein membrane anchor with glycosphingolipid microdomains 1 |
increases expression |
ISO |
Aspirin results in increased expression of PAG1 mRNA |
CTD |
PMID:15928584 |
|
NCBI chr 2:91,935,378...92,076,937
Ensembl chr 2:92,057,216...92,069,849
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions increases cleavage |
ISO |
[Aspirin co-treated with TNFSF10 protein] results in increased cleavage of PARP1 protein; Aspirin inhibits the reaction [Deoxycholic Acid results in increased cleavage of PARP1 protein]; Aspirin promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]; Aspirin promotes the reaction [troglitazone results in increased cleavage of PARP1 protein]; Aspirin results in increased cleavage of and results in increased activity of PARP1 protein; BCL2 protein inhibits the reaction [Aspirin promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; troglitazone promotes the reaction [Aspirin results in increased cleavage of PARP1 protein] |
CTD |
PMID:9694730 PMID:11228543 PMID:11532860 PMID:15481331 PMID:16199534 PMID:17644113 PMID:18483385 PMID:19595669 PMID:19908241 More...
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pcbp1 |
poly(rC) binding protein 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of PCBP1 mRNA |
CTD |
PMID:15928584 |
|
NCBI chr 4:118,972,698...118,974,705
Ensembl chr 4:118,972,661...118,976,500
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G |
Pcdh17 |
protocadherin 17 |
increases expression |
ISO |
Aspirin results in increased expression of PCDH17 mRNA |
CTD |
PMID:11906190 |
|
NCBI chr15:60,222,088...60,316,172
Ensembl chr15:60,222,004...60,313,999
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G |
Pcna |
proliferating cell nuclear antigen |
increases expression |
EXP |
Aspirin results in increased expression of PCNA protein |
CTD |
PMID:14563943 |
|
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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G |
Pcnp |
PEST proteolytic signal containing nuclear protein |
increases expression |
ISO |
Aspirin results in increased expression of PCNP mRNA |
CTD |
PMID:15928584 |
|
NCBI chr11:44,592,766...44,607,372
Ensembl chr11:44,592,742...44,607,348
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G |
Pcsk1 |
proprotein convertase subtilisin/kexin type 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of PCSK1 mRNA |
CTD |
PMID:11906190 |
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NCBI chr 2:4,395,543...4,442,434
Ensembl chr 2:4,395,543...4,442,434
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G |
Pcsk7 |
proprotein convertase subtilisin/kexin type 7 |
decreases expression |
ISO |
Aspirin results in decreased expression of PCSK7 mRNA |
CTD |
PMID:15928584 |
|
NCBI chr 8:46,202,079...46,224,699
Ensembl chr 8:46,202,131...46,224,705
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G |
Pdcd10 |
programmed cell death 10 |
increases expression |
ISO |
Aspirin results in increased expression of PDCD10 mRNA |
CTD |
PMID:15928584 |
|
NCBI chr 2:160,303,465...160,346,086
Ensembl chr 2:160,303,449...160,346,018
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G |
Pdgfb |
platelet derived growth factor subunit B |
multiple interactions |
ISO |
Aspirin promotes the reaction [Adenosine Diphosphate results in increased secretion of PDGFB protein] |
CTD |
PMID:17303692 |
|
NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
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G |
Pdlim7 |
PDZ and LIM domain 7 |
decreases expression |
ISO |
Aspirin results in decreased expression of PDLIM7 mRNA |
CTD |
PMID:15928584 |
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NCBI chr17:9,124,565...9,139,814
Ensembl chr17:9,124,649...9,139,811
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G |
Pecam1 |
platelet and endothelial cell adhesion molecule 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of PECAM1 mRNA; Aspirin results in decreased expression of PECAM1 protein |
CTD |
PMID:15381054 PMID:15456535 |
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NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
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G |
Pef1 |
penta-EF hand domain containing 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of PEF1 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 5:142,451,791...142,475,061
Ensembl chr 5:142,451,778...142,475,067
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G |
Pepd |
peptidase D |
increases activity |
ISO |
Aspirin results in increased activity of PEPD protein |
CTD |
PMID:16991207 |
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NCBI chr 1:87,536,650...87,681,233
Ensembl chr 1:87,536,609...87,681,231
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G |
Pf4 |
platelet factor 4 |
multiple interactions |
ISO |
Aspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of PF4 protein] |
CTD |
PMID:17303692 |
|
NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365
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G |
Pfkfb3 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 |
decreases expression |
ISO |
Aspirin results in decreased expression of PFKFB3 mRNA |
CTD |
PMID:11906190 |
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NCBI chr17:66,983,629...67,064,702
Ensembl chr17:66,983,686...67,063,125
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G |
Pfn1 |
profilin 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of PFN1 mRNA |
CTD |
PMID:15928584 |
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NCBI chr10:55,365,263...55,367,968
Ensembl chr10:55,365,262...55,527,631
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G |
Phb1 |
prohibitin 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of PHB1 mRNA |
CTD |
PMID:14976132 |
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NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042
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G |
Phb2 |
prohibitin 2 |
decreases expression |
ISO |
Aspirin results in decreased expression of PHB2 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 4:157,517,662...157,522,268
Ensembl chr 4:157,517,577...157,522,272
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G |
Pi4kb |
phosphatidylinositol 4-kinase beta |
decreases expression |
ISO |
Aspirin results in decreased expression of PI4KB mRNA |
CTD |
PMID:15928584 |
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NCBI chr 2:182,540,377...182,572,684
Ensembl chr 2:182,540,567...182,588,488
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G |
Picalm |
phosphatidylinositol binding clathrin assembly protein |
decreases expression |
ISO |
Aspirin results in decreased expression of PICALM mRNA |
CTD |
PMID:11906190 |
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NCBI chr 1:144,056,415...144,138,045
Ensembl chr 1:144,056,721...144,137,557
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G |
Pik3c2a |
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha |
decreases expression |
ISO |
Aspirin results in decreased expression of PIK3C2A mRNA |
CTD |
PMID:11906190 |
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NCBI chr 1:170,577,942...170,684,353
Ensembl chr 1:170,577,942...170,683,472
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G |
Pik3r1 |
phosphoinositide-3-kinase regulatory subunit 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of PIK3R1 mRNA |
CTD |
PMID:20457246 |
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NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631
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G |
Pilrb2l8 |
paired immunoglobin like type 2 receptor beta 2 like 8 |
increases expression |
ISO |
Aspirin results in increased expression of ZNF37A mRNA |
CTD |
PMID:11906190 |
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NCBI chr12:17,744,315...17,756,074
Ensembl chr12:17,752,830...17,755,922
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G |
Pitx1 |
paired-like homeodomain 1 |
increases expression |
ISO |
Aspirin results in increased expression of PITX1 mRNA |
CTD |
PMID:11906190 |
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NCBI chr17:8,794,134...8,800,292
Ensembl chr17:8,794,134...8,800,291
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G |
Pla2g4a |
phospholipase A2 group 4A |
decreases expression |
ISO |
Aspirin results in decreased expression of PLA2G4A mRNA |
CTD |
PMID:10706128 |
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NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266
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G |
Pla2g6 |
phospholipase A2 group VI |
increases expression |
ISO |
Aspirin results in increased expression of PLA2G6 mRNA |
CTD |
PMID:11906190 |
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NCBI chr 7:110,851,378...110,891,557
Ensembl chr 7:110,851,378...110,891,114
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G |
Plaur |
plasminogen activator, urokinase receptor |
multiple interactions affects expression increases expression |
ISO EXP |
Aspirin promotes the reaction [FOSL1 protein binds to PLAUR promoter]; Aspirin promotes the reaction [H4C16 protein modified form binds to PLAUR promoter]; Aspirin promotes the reaction [JUN protein binds to PLAUR promoter] Aspirin affects the expression of PLAUR mRNA Aspirin results in increased expression of PLAUR mRNA; Aspirin results in increased expression of PLAUR protein |
CTD |
PMID:12800193 PMID:16893520 |
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NCBI chr 1:80,053,440...80,068,384
Ensembl chr 1:80,050,324...80,068,595
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G |
Plcd4 |
phospholipase C, delta 4 |
increases expression |
EXP |
Aspirin results in increased expression of PLCD4 mRNA |
CTD |
PMID:12800193 |
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NCBI chr 9:76,115,523...76,158,602
Ensembl chr 9:76,117,168...76,142,453
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G |
Plin2 |
perilipin 2 |
increases expression |
EXP |
Aspirin results in increased expression of PLIN2 mRNA |
CTD |
PMID:12800193 |
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NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319
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G |
Pmaip1 |
phorbol-12-myristate-13-acetate-induced protein 1 |
increases expression increases response to substance |
ISO |
Aspirin results in increased expression of PMAIP1 mRNA; Aspirin results in increased expression of PMAIP1 protein PMAIP1 results in increased susceptibility to Aspirin |
CTD |
PMID:15928584 PMID:19936928 |
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NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429
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G |
Polr2a |
RNA polymerase II subunit A |
increases expression |
ISO |
Aspirin results in increased expression of POLR2A mRNA |
CTD |
PMID:11906190 |
|
NCBI chr10:54,452,438...54,478,486
Ensembl chr10:54,452,441...54,478,455
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G |
Pon1 |
paraoxonase 1 |
increases expression increases activity multiple interactions |
ISO EXP |
Aspirin results in increased expression of PON1 mRNA Aspirin results in increased activity of PON1 mRNA; Aspirin results in increased activity of PON1 protein AHR mutant form inhibits the reaction [Aspirin results in increased activity of PON1 protein]; AHR mutant form inhibits the reaction [Aspirin results in increased expression of PON1 mRNA] |
CTD |
PMID:18519978 |
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NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
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G |
Por |
cytochrome p450 oxidoreductase |
decreases expression |
ISO |
Aspirin results in decreased expression of POR mRNA |
CTD |
PMID:15928584 |
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NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
affects activity multiple interactions increases expression decreases expression decreases activity |
ISO |
Aspirin affects the activity of PPARA protein PPARA affects the reaction [Aspirin affects the expression of ABCA1 mRNA]; PPARA affects the reaction [Aspirin affects the expression of ABCA1 protein]; PPARA affects the reaction [Aspirin promotes the reaction [APOA1 affects the transport of Cholesterol]] Aspirin results in increased expression of PPARA mRNA Aspirin results in increased expression of PPARA; Aspirin results in increased expression of PPARA mRNA; Aspirin results in increased expression of PPARA protein Aspirin results in decreased expression of PPARA protein Aspirin results in decreased activity of PPARA protein |
CTD |
PMID:15646027 PMID:16816107 PMID:18971601 PMID:19462226 PMID:19880272 PMID:21088444 More...
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NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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G |
Ppard |
peroxisome proliferator-activated receptor delta |
decreases activity increases expression decreases expression |
ISO EXP |
Aspirin results in decreased activity of PPARD protein Aspirin results in increased expression of PPARD mRNA Aspirin results in decreased expression of PPARD protein |
CTD |
PMID:12800193 PMID:15646027 PMID:18678619 |
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NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
decreases activity decreases expression increases expression multiple interactions |
ISO EXP |
Aspirin results in decreased activity of PPARG protein Aspirin results in decreased expression of PPARG mRNA Aspirin results in increased expression of PPARG mRNA Aspirin results in increased expression of PPARG; Aspirin results in increased expression of PPARG mRNA; Aspirin results in increased expression of PPARG protein Aspirin inhibits the reaction [Niacin results in increased activity of PPARG protein] |
CTD |
PMID:15646027 PMID:16386710 PMID:18222077 PMID:18971601 PMID:19462226 PMID:19880272 More...
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NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Ppargc1a |
PPARG coactivator 1 alpha |
multiple interactions |
ISO |
Aspirin inhibits the reaction [Cisplatin results in decreased expression of PPARGC1A mRNA] |
CTD |
PMID:37179038 |
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NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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G |
Ppbp |
pro-platelet basic protein |
multiple interactions |
ISO |
Aspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of PPBP protein] |
CTD |
PMID:17303692 |
|
NCBI chr14:17,302,326...17,303,130
Ensembl chr14:17,302,326...17,303,130
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G |
Ppib |
peptidylprolyl isomerase B |
decreases expression |
ISO |
Aspirin results in decreased expression of PPIB mRNA |
CTD |
PMID:15928584 |
|
NCBI chr 8:66,603,877...66,609,734
Ensembl chr 8:66,603,861...66,630,428
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G |
Ppig |
peptidylprolyl isomerase G |
increases expression |
ISO |
Aspirin results in increased expression of PPIG mRNA |
CTD |
PMID:15928584 |
|
NCBI chr 3:54,484,023...54,512,929
Ensembl chr 3:54,484,023...54,512,926
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G |
Ppp1r12a |
protein phosphatase 1, regulatory subunit 12A |
decreases expression |
ISO |
Aspirin results in decreased expression of PPP1R12A mRNA |
CTD |
PMID:11906190 |
|
NCBI chr 7:43,482,808...43,593,689
Ensembl chr 7:43,482,803...43,593,425
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G |
Ppp1r15a |
protein phosphatase 1, regulatory subunit 15A |
increases expression |
EXP |
Aspirin results in increased expression of PPP1R15A mRNA |
CTD |
PMID:12800193 |
|
NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
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G |
Ppp1r2 |
protein phosphatase 1, regulatory (inhibitor) subunit 2 |
decreases expression |
ISO |
Aspirin results in decreased expression of PPP1R2 mRNA |
CTD |
PMID:11906190 |
|
NCBI chr11:69,472,676...69,494,468
Ensembl chr11:69,472,555...69,494,463
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G |
Ppp4c |
protein phosphatase 4, catalytic subunit |
decreases expression |
ISO |
Aspirin results in decreased expression of PPP4C mRNA |
CTD |
PMID:15928584 |
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NCBI chr 1:181,392,899...181,399,703
Ensembl chr 1:181,392,923...181,399,659
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G |
Prep |
prolyl endopeptidase |
decreases expression |
ISO |
Aspirin results in decreased expression of PREP mRNA |
CTD |
PMID:15928584 |
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NCBI chr20:48,556,211...48,653,165
Ensembl chr20:48,556,280...48,654,466
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G |
Prkaa1 |
protein kinase AMP-activated catalytic subunit alpha 1 |
increases expression multiple interactions |
ISO |
Aspirin results in increased expression of PRKAA1 protein modified form Aspirin inhibits the reaction [Cisplatin results in decreased expression of PRKAA1 protein] CES1 protein promotes the reaction [Aspirin results in increased expression of PRKAA1 protein modified form] |
CTD |
PMID:25743752 PMID:37179038 |
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NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
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G |
Prkcb |
protein kinase C, beta |
multiple interactions affects expression |
ISO |
Aspirin inhibits the reaction [Deoxycholic Acid results in increased expression of PRKCB protein] Aspirin affects the expression of PRKCB protein |
CTD |
PMID:17644113 |
|
NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
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G |
Prkcd |
protein kinase C, delta |
increases cleavage |
ISO |
Aspirin results in increased cleavage of PRKCD protein |
CTD |
PMID:11228543 |
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NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352
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G |
Prkce |
protein kinase C, epsilon |
multiple interactions |
ISO |
Aspirin inhibits the reaction [Deoxycholic Acid results in increased cleavage of PRKCE protein] |
CTD |
PMID:17644113 |
|
NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719
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G |
Prnp |
prion protein |
increases expression |
EXP |
Aspirin results in increased expression of PRNP mRNA |
CTD |
PMID:12800193 |
|
NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937
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G |
Psat1 |
phosphoserine aminotransferase 1 |
decreases expression |
EXP |
Aspirin results in decreased expression of PSAT1 mRNA |
CTD |
PMID:12800193 |
|
NCBI chr 1:213,196,709...213,218,564
Ensembl chr 1:213,196,709...213,218,682
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G |
Psd |
pleckstrin and Sec7 domain containing |
increases expression |
ISO |
Aspirin results in increased expression of PSD mRNA |
CTD |
PMID:11906190 |
|
NCBI chr 1:245,173,279...245,188,681
Ensembl chr 1:245,173,279...245,189,356
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G |
Psmc6 |
proteasome 26S subunit, ATPase 6 |
decreases expression |
ISO |
Aspirin results in decreased expression of PSMC6 mRNA |
CTD |
PMID:11906190 |
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NCBI chr15:18,542,585...18,564,057
Ensembl chr15:18,542,563...18,564,055
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G |
Psmd12 |
proteasome 26S subunit, non-ATPase 12 |
increases expression |
ISO |
Aspirin results in increased expression of PSMD12 mRNA |
CTD |
PMID:15928584 |
|
NCBI chr10:92,438,223...92,457,323
Ensembl chr10:92,438,298...92,457,287
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G |
Ptgdr2 |
prostaglandin D2 receptor 2 |
affects response to substance |
ISO |
PTGDR2 gene SNP affects the susceptibility to Aspirin |
CTD |
PMID:20485159 |
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NCBI chr 1:207,585,088...207,590,275
Ensembl chr 1:207,587,917...207,589,213
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G |
Ptger2 |
prostaglandin E receptor 2 |
affects response to substance |
ISO |
PTGER2 SNP affects the susceptibility to Aspirin |
CTD |
PMID:15496426 |
|
NCBI chr15:18,215,013...18,228,714
Ensembl chr15:18,217,285...18,228,714
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G |
Ptger3 |
prostaglandin E receptor 3 |
affects response to substance |
ISO |
PTGER3 polymorphism affects the susceptibility to Aspirin |
CTD |
PMID:20587336 |
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NCBI chr 2:246,606,131...246,750,970
Ensembl chr 2:246,606,183...246,684,434
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G |
Ptges |
prostaglandin E synthase |
decreases expression |
ISO |
Aspirin results in decreased expression of PTGES mRNA; Aspirin results in decreased expression of PTGES protein |
CTD |
PMID:19880272 |
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NCBI chr 3:14,177,892...14,189,236
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G |
Ptgir |
prostaglandin I2 receptor |
affects response to substance |
ISO |
PTGIR gene SNP affects the susceptibility to Aspirin |
CTD |
PMID:20485159 |
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NCBI chr 1:77,579,596...77,581,979
Ensembl chr 1:77,579,596...77,581,979
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G |
Ptgs1 |
prostaglandin-endoperoxide synthase 1 |
multiple interactions affects expression affects response to substance decreases activity decreases expression decreases response to substance increases acetylation |
ISO EXP |
[Aspirin results in increased acetylation of PTGS1 protein] which results in decreased chemical synthesis of Thromboxane A2; Aspirin inhibits the reaction [[Arachidonic Acid results in increased activity of PTGS1 protein] which results in increased susceptibility to Methamphetamine]; Aspirin inhibits the reaction [Arachidonic Acid results in increased activity of PTGS1 protein]; Aspirin inhibits the reaction [PTGS1 protein results in increased susceptibility to Methamphetamine]; PTGS1 mutant form inhibits the reaction [Aspirin promotes the reaction [romidepsin results in increased expression of CDKN1A protein]] Aspirin affects the expression of PTGS1 protein PTGS1 polymorphism affects the susceptibility to Aspirin Aspirin analog results in decreased activity of PTGS1 protein; Aspirin results in decreased activity of PTGS1 protein Aspirin results in decreased expression of PTGS1 mRNA Aspirin promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of PTGS1 protein]; PTGS1 results in decreased susceptibility to [Hydrochloric Acid co-treated with Aspirin] PTGS1 gene polymorphism results in decreased susceptibility to Aspirin; PTGS1 gene SNP results in decreased susceptibility to Aspirin |
CTD |
PMID:12242329 PMID:15236176 PMID:15843042 PMID:16141368 PMID:16150050 PMID:16484611 PMID:16493486 PMID:19036898 PMID:19390185 PMID:19493461 PMID:20404564 PMID:21163909 PMID:21513785 PMID:23533533 More...
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NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions decreases activity increases expression decreases expression affects response to substance decreases degradation |
ISO EXP |
Ascorbic Acid inhibits the reaction [Aspirin results in increased expression of PTGS2 mRNA]; Aspirin inhibits the reaction [[Arachidonic Acid results in increased activity of PTGS2 protein] which results in increased susceptibility to Methamphetamine]; Aspirin inhibits the reaction [Arachidonic Acid results in increased activity of PTGS2 protein]; Aspirin inhibits the reaction [HMGB1 protein results in increased expression of PTGS2 protein]; Aspirin inhibits the reaction [PTGS2 protein results in increased susceptibility to Methamphetamine]; Aspirin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; Aspirin inhibits the reaction [TNF results in increased expression of PTGS2 mRNA]; Aspirin inhibits the reaction [TNF results in increased expression of PTGS2 protein]; Aspirin promotes the reaction [IL1A results in increased expression of PTGS2 mRNA]; Aspirin promotes the reaction [IL1A results in increased expression of PTGS2 protein]; IL1A promotes the reaction [Aspirin results in increased expression of PTGS2 mRNA]; IL1A promotes the reaction [Aspirin results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [Aspirin results in decreased degradation of PTGS2 mRNA]; SB 203580 inhibits the reaction [Aspirin results in increased expression of PTGS2 mRNA]; SB 203580 inhibits the reaction [Aspirin results in increased expression of PTGS2 protein] Aspirin results in decreased activity of PTGS2 protein; Aspirin results in decreased activity of PTGS2 protein mutant form Aspirin results in increased expression of PTGS2; Aspirin results in increased expression of PTGS2 mRNA; Aspirin results in increased expression of PTGS2 protein Aspirin results in decreased expression of PTGS2 protein [Aspirin co-treated with Hydrochloric Acid] results in increased expression of PTGS2 mRNA; [telmisartan co-treated with Aspirin] inhibits the reaction [Streptozocin results in increased expression of PTGS2 protein]; Ampicillin inhibits the reaction [Aspirin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 mRNA]]; apple polyphenol extract inhibits the reaction [Aspirin results in increased expression of PTGS2 mRNA]; apple polyphenol extract inhibits the reaction [Aspirin results in increased expression of PTGS2 protein]; Aspirin inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]; Aspirin inhibits the reaction [Streptozocin results in increased expression of PTGS2 protein]; Aspirin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 mRNA] [[Aspirin co-treated with Hydrochloric Acid] results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; [Aspirin co-treated with Hydrochloric Acid] results in increased expression of PTGS2 mRNA; [Aspirin co-treated with Hydrochloric Acid] results in increased expression of PTGS2 protein; Aspirin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; Aspirin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein] PTGS2 gene SNP affects the susceptibility to Aspirin; PTGS2 SNP affects the susceptibility to Aspirin Aspirin results in decreased expression of PTGS2 mRNA; Aspirin results in decreased expression of PTGS2 protein |
CTD |
PMID:9726391 PMID:10706128 PMID:12231391 PMID:12781040 PMID:14742690 PMID:15236176 PMID:15489888 PMID:15843042 PMID:15861417 PMID:16310244 PMID:16336399 PMID:16804302 PMID:17218764 PMID:17595529 PMID:18197933 PMID:18482463 PMID:19493461 PMID:19755647 PMID:19880272 PMID:20223228 PMID:20485159 PMID:21163909 PMID:21360558 PMID:21513785 PMID:21893697 PMID:22245433 PMID:32816093 PMID:34755645 More...
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Ptp4a1 |
protein tyrosine phosphatase 4A1 |
increases expression |
ISO |
Aspirin results in increased expression of PTP4A1 mRNA |
CTD |
PMID:14976132 |
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NCBI chr 9:33,214,201...33,245,046
Ensembl chr 9:33,214,208...33,221,964
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G |
Ptprcap |
protein tyrosine phosphatase, receptor type, C-associated protein |
decreases expression |
ISO |
Aspirin results in decreased expression of PTPRCAP mRNA |
CTD |
PMID:15928584 |
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NCBI chr 1:201,449,133...201,451,293
Ensembl chr 1:201,449,113...201,451,288
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G |
Pum2 |
pumilio RNA-binding family member 2 |
increases expression |
ISO |
Aspirin results in increased expression of PUM2 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 6:31,462,879...31,542,976
Ensembl chr 6:31,462,872...31,542,976
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G |
Pura |
purine rich element binding protein A |
increases expression |
EXP |
Aspirin results in increased expression of PURA mRNA |
CTD |
PMID:12800193 |
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NCBI chr18:27,885,071...27,905,509
Ensembl chr18:27,884,556...27,905,513
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G |
Pus1 |
pseudouridine synthase 1 |
increases expression |
ISO |
Aspirin results in increased expression of PUS1 mRNA |
CTD |
PMID:15456535 |
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NCBI chr12:45,880,364...45,889,196
Ensembl chr12:45,880,440...45,889,196
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G |
Pxn |
paxillin |
decreases expression |
ISO |
Aspirin results in decreased expression of PXN mRNA |
CTD |
PMID:15928584 |
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NCBI chr12:41,060,791...41,107,952
Ensembl chr12:41,060,791...41,107,931
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G |
Pygl |
glycogen phosphorylase L |
affects binding |
EXP |
Aspirin binds to PYGL protein |
CTD |
PMID:15236443 |
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NCBI chr 6:88,697,598...88,740,260
Ensembl chr 6:88,697,593...88,740,310
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G |
Rab2a |
RAB2A, member RAS oncogene family |
increases expression |
ISO |
Aspirin results in increased expression of RAB2A mRNA |
CTD |
PMID:15456535 |
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NCBI chr 5:21,676,017...21,740,035
Ensembl chr 5:21,676,129...21,739,899
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G |
Rabggta |
Rab geranylgeranyltransferase subunit alpha |
increases expression |
ISO |
Aspirin results in increased expression of RABGGTA mRNA |
CTD |
PMID:11906190 |
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NCBI chr15:29,206,328...29,213,398
Ensembl chr15:29,206,157...29,213,348
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G |
Rac1 |
Rac family small GTPase 1 |
increases expression |
ISO |
Aspirin results in increased expression of RAC1 mRNA; Aspirin results in increased expression of RAC1 protein |
CTD |
PMID:14976132 |
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NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
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G |
Raf1 |
Raf-1 proto-oncogene, serine/threonine kinase |
decreases expression |
ISO |
Aspirin results in decreased expression of RAF1 mRNA |
CTD |
PMID:20457246 |
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NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
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G |
Ralb |
RAS like proto-oncogene B |
decreases expression |
ISO |
Aspirin results in decreased expression of RALB mRNA |
CTD |
PMID:11906190 |
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NCBI chr13:30,588,036...30,624,199
Ensembl chr13:30,588,033...30,624,202
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G |
Rb1 |
RB transcriptional corepressor 1 |
multiple interactions increases expression decreases expression |
ISO |
Aspirin inhibits the reaction [troglitazone results in decreased expression of RB1 protein modified form]; Aspirin promotes the reaction [troglitazone results in increased expression of RB1 protein]; troglitazone inhibits the reaction [Aspirin results in decreased expression of RB1 protein modified form]; troglitazone promotes the reaction [Aspirin results in increased expression of RB1 protein] |
CTD |
PMID:19908241 |
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NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
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G |
Reep6 |
receptor accessory protein 6 |
increases expression |
ISO |
Aspirin results in increased expression of REEP6 mRNA |
CTD |
PMID:11906190 |
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NCBI chr 7:9,373,927...9,380,845
Ensembl chr 7:9,373,927...9,380,597
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G |
Reg1a |
regenerating family member 1 alpha |
decreases response to substance increases expression |
EXP |
REG1A results in decreased susceptibility to Aspirin Aspirin results in increased expression of REG1A mRNA; Aspirin results in increased expression of REG1A protein |
CTD |
PMID:14563943 |
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NCBI chr 4:110,892,451...110,895,115
Ensembl chr 4:110,892,453...110,895,570
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions decreases localization increases localization |
ISO EXP |
Aspirin inhibits the reaction [Glucose results in increased expression of RELA protein]; Aspirin inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]; Aspirin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Aspirin inhibits the reaction [TNF protein results in increased activity of RELA protein]; Aspirin results in decreased localization of and results in decreased activity of RELA protein Aspirin results in decreased localization of RELA protein [telmisartan co-treated with Aspirin] inhibits the reaction [Streptozocin results in increased expression of RELA protein]; Aspirin inhibits the reaction [[Lipopolysaccharides co-treated with TNF protein co-treated with IL1B protein] results in increased activity of RELA protein]; Aspirin inhibits the reaction [Streptozocin results in increased expression of RELA protein] [Pertussis Toxin co-treated with Dithiothreitol] inhibits the reaction [Aspirin inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]]; Aspirin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] affects the localization of and results in increased phosphorylation of RELA protein]; Aspirin inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]; Aspirin inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein] Aspirin results in increased localization of RELA protein |
CTD |
PMID:9281604 PMID:10328874 PMID:11826407 PMID:15188000 PMID:15489888 PMID:15770215 PMID:16600694 PMID:17259377 PMID:18786831 PMID:20137092 PMID:20223228 PMID:25449198 More...
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Ren |
renin |
decreases activity |
ISO |
Aspirin results in decreased activity of REN protein |
CTD |
PMID:7994448 PMID:19805643 |
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NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
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G |
Rgs7bp |
regulator of G-protein signaling 7 binding protein |
affects response to substance |
ISO |
RGS7BP polymorphism affects the susceptibility to Aspirin |
CTD |
PMID:21457877 |
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NCBI chr 2:36,133,944...36,231,505
Ensembl chr 2:36,139,201...36,231,505
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G |
Rhog |
ras homolog family member G |
decreases expression |
ISO |
Aspirin results in decreased expression of RHOG mRNA |
CTD |
PMID:15928584 |
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NCBI chr 1:156,618,713...156,630,710
Ensembl chr 1:156,615,349...156,631,257
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G |
Rnase1 |
ribonuclease A family member 1, pancreatic |
increases expression |
ISO |
Aspirin results in increased expression of RNASE1 mRNA |
CTD |
PMID:11906190 |
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NCBI chr15:24,361,924...24,363,633
Ensembl chr15:24,361,927...24,363,624
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G |
Rnase6 |
ribonuclease A family member 6 |
increases expression |
ISO |
Aspirin results in increased expression of RNASE6 mRNA |
CTD |
PMID:11906190 |
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NCBI chr15:24,354,305...24,357,289
Ensembl chr15:24,354,303...24,357,328
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G |
Rnd2 |
Rho family GTPase 2 |
increases expression |
ISO |
Aspirin results in increased expression of RND2 mRNA |
CTD |
PMID:11906190 |
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NCBI chr10:86,399,151...86,402,750
Ensembl chr10:86,399,148...86,402,742
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G |
Rnf26 |
ring finger protein 26 |
increases expression |
ISO |
Aspirin results in increased expression of RNF26 mRNA |
CTD |
PMID:11906190 |
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NCBI chr 8:44,454,551...44,456,745
Ensembl chr 8:44,454,292...44,457,331
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G |
Rpl34 |
ribosomal protein L34 |
increases expression |
ISO |
Aspirin results in increased expression of RPL34 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 2:219,284,373...219,288,108
Ensembl chr 2:219,284,382...219,288,111 Ensembl chr17:219,284,382...219,288,111
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G |
Rpn1 |
ribophorin I |
decreases expression |
ISO |
Aspirin results in decreased expression of RPN1 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 4:120,543,667...120,565,069
Ensembl chr 4:120,543,667...120,565,069
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G |
Rps16 |
ribosomal protein S16 |
increases expression |
ISO |
Aspirin results in increased expression of RPS16 mRNA |
CTD |
PMID:14976132 |
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NCBI chr 1:83,643,066...83,646,056
Ensembl chr 1:83,643,130...83,646,206 Ensembl chr19:83,643,130...83,646,206
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G |
Rps19 |
ribosomal protein S19 |
increases expression |
ISO |
Aspirin results in increased expression of RPS19 mRNA |
CTD |
PMID:15456535 |
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NCBI chr 1:80,480,718...80,486,511
Ensembl chr 1:80,480,951...80,486,508 Ensembl chr 7:80,480,951...80,486,508
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G |
Rps27a |
ribosomal protein S27a |
increases expression |
ISO |
Aspirin results in increased expression of RPS27A mRNA |
CTD |
PMID:15928584 |
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NCBI chr14:103,285,734...103,288,011
Ensembl chr14:103,285,734...103,288,011 Ensembl chr 5:103,285,734...103,288,011 Ensembl chr 5:103,285,734...103,288,011
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G |
Rps6 |
ribosomal protein S6 |
decreases phosphorylation |
ISO |
Aspirin results in decreased phosphorylation of RPS6 protein |
CTD |
PMID:23363784 |
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NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602 Ensembl chr 5:101,371,136...101,374,602
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G |
Rps6kb1 |
ribosomal protein S6 kinase B1 |
multiple interactions |
ISO |
Aspirin results in decreased phosphorylation of and results in decreased activity of RPS6KB1 protein |
CTD |
PMID:10993886 |
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NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
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G |
RT1-Db1 |
RT1 class II, locus Db1 |
affects response to substance |
ISO |
HLA-DRB1 gene SNP affects the susceptibility to Aspirin |
CTD |
PMID:20485159 |
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NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
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G |
RT1-M3-1 |
RT1 class Ib, locus M3, gene 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of HLA-G mRNA |
CTD |
PMID:14976132 |
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NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117
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G |
S100a11 |
S100 calcium binding protein A11 |
decreases expression |
ISO |
Aspirin results in decreased expression of S100A11 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 2:179,191,688...179,197,098
Ensembl chr 2:179,191,715...179,197,044
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G |
S100a4 |
S100 calcium-binding protein A4 |
increases expression decreases expression |
ISO |
Aspirin results in increased expression of S100A4 mRNA Aspirin results in decreased expression of S100A4 mRNA |
CTD |
PMID:14976132 PMID:20457246 |
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NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254
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G |
Sat1 |
spermidine/spermine N1-acetyl transferase 1 |
multiple interactions increases expression |
ISO |
Aspirin promotes the reaction [NFKB1 protein binds to SAT1 promoter]; Aspirin results in increased expression of and results in increased activity of SAT1 protein Aspirin results in increased expression of SAT1 mRNA |
CTD |
PMID:16262603 |
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NCBI chr X:40,158,354...40,161,641
Ensembl chr X:40,157,046...40,196,813
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G |
Sbsn |
suprabasin |
multiple interactions |
ISO |
Aspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of SBSN protein] |
CTD |
PMID:17303692 |
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NCBI chr 1:85,978,970...86,006,034
Ensembl chr 1:86,001,567...86,006,034
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G |
Scarb1 |
scavenger receptor class B, member 1 |
affects expression increases expression decreases expression multiple interactions |
ISO |
Aspirin affects the expression of SCARB1 mRNA Aspirin results in increased expression of SCARB1 mRNA; Aspirin results in increased expression of SCARB1 protein Aspirin affects the expression of SCARB1 protein Aspirin results in decreased expression of SCARB1 mRNA [Aspirin co-treated with Fenofibrate] results in increased expression of SCARB1 protein; Aspirin inhibits the reaction [Niacin results in increased expression of SCARB1 mRNA]; Aspirin results in decreased expression of and results in decreased activity of SCARB1 protein; Aspirin results in increased expression of and results in increased activity of SCARB1 protein |
CTD |
PMID:15037193 PMID:16816107 PMID:20137092 |
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NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
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G |
Scfd2 |
sec1 family domain containing 2 |
increases expression |
ISO |
Aspirin results in increased expression of SCFD2 mRNA |
CTD |
PMID:11906190 |
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NCBI chr14:33,683,348...34,008,232
Ensembl chr14:33,683,273...34,008,213
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G |
Scn1b |
sodium voltage-gated channel beta subunit 1 |
increases expression |
ISO |
Aspirin results in increased expression of SCN1B mRNA |
CTD |
PMID:11906190 |
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NCBI chr 1:86,353,917...86,363,820
Ensembl chr 1:86,353,917...86,363,739
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G |
Sdc4 |
syndecan 4 |
decreases expression |
ISO |
Aspirin results in decreased expression of SDC4 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 3:153,154,888...153,173,576
Ensembl chr 3:153,154,896...153,173,580
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G |
Sds |
serine dehydratase |
increases expression |
ISO |
Aspirin results in increased expression of SDS mRNA |
CTD |
PMID:11906190 |
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NCBI chr12:36,083,226...36,090,540
Ensembl chr12:36,083,229...36,088,203
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G |
Sec13 |
SEC13 homolog, nuclear pore and COPII coat complex component |
decreases expression |
ISO |
Aspirin results in decreased expression of SEC13 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 4:146,877,739...146,891,130
Ensembl chr 4:146,875,524...146,891,173
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G |
Selenom |
selenoprotein M |
increases expression |
ISO |
Aspirin results in increased expression of SELENOM mRNA |
CTD |
PMID:11906190 |
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NCBI chr14:78,395,826...78,398,429
Ensembl chr14:78,395,826...78,398,429
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G |
Sell |
selectin L |
decreases expression |
ISO |
Aspirin results in decreased expression of SELL protein |
CTD |
PMID:12147693 |
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NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456
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G |
Selp |
selectin P |
decreases expression multiple interactions increases expression |
ISO |
Aspirin results in decreased expression of SELP protein Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of SELP protein]; Glucose inhibits the reaction [Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of SELP protein]] Aspirin results in increased expression of SELP protein |
CTD |
PMID:15140583 PMID:15381054 PMID:16756193 PMID:17543677 PMID:18413191 |
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NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845
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G |
Serpina1 |
serpin family A member 1 |
multiple interactions |
ISO |
Aspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of SERPINA1 protein] |
CTD |
PMID:17303692 |
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NCBI chr 6:122,866,314...122,888,339
Ensembl chr 6:122,866,312...122,888,339
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G |
Serpina3n |
serpin family A member 3N |
decreases expression increases expression |
ISO |
Aspirin results in decreased expression of SERPINA3 mRNA Aspirin results in increased expression of SERPINA3 mRNA |
CTD |
PMID:11906190 PMID:15456535 |
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NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433
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G |
Serpinb1a |
serpin family B member 1A |
decreases expression |
ISO |
Aspirin results in decreased expression of SERPINB1 mRNA |
CTD |
PMID:14976132 |
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NCBI chr17:31,590,695...31,599,102
Ensembl chr17:31,590,677...31,599,102
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G |
Serpinb2 |
serpin family B member 2 |
decreases expression |
ISO |
Aspirin results in decreased expression of SERPINB2 mRNA |
CTD |
PMID:15456535 |
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NCBI chr13:23,537,312...23,551,823
Ensembl chr13:23,541,400...23,550,408
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G |
Serpinb5 |
serpin family B member 5 |
increases expression |
ISO |
Aspirin results in increased expression of SERPINB5 protein |
CTD |
PMID:16546864 |
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NCBI chr13:22,985,557...23,005,756
Ensembl chr13:22,985,557...23,005,756
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G |
Sfpq |
splicing factor proline and glutamine rich |
decreases expression |
EXP |
Aspirin results in decreased expression of SFPQ mRNA |
CTD |
PMID:12800193 |
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NCBI chr 5:139,338,034...139,353,476
Ensembl chr 5:139,338,075...139,353,472
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G |
Sftpd |
surfactant protein D |
increases expression |
ISO |
Aspirin results in increased expression of SFTPD mRNA |
CTD |
PMID:15456535 |
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NCBI chr16:17,046,491...17,058,968
Ensembl chr16:17,046,483...17,059,927
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G |
Si |
sucrase-isomaltase |
increases activity decreases activity |
ISO EXP |
Aspirin results in increased activity of SI protein Aspirin results in decreased activity of SI protein |
CTD |
PMID:9399670 PMID:18604318 |
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NCBI chr 2:157,505,893...157,586,228
Ensembl chr 2:157,506,342...157,585,260
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G |
Siah2 |
siah E3 ubiquitin protein ligase 2 |
decreases expression |
ISO |
Aspirin results in decreased expression of SIAH2 mRNA |
CTD |
PMID:15928584 |
|
NCBI chr 2:142,913,924...142,931,752
Ensembl chr 2:142,914,003...142,931,950
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G |
Sirt1 |
sirtuin 1 |
multiple interactions |
ISO |
Aspirin inhibits the reaction [Everolimus results in decreased expression of SIRT1 protein]; Aspirin inhibits the reaction [Paclitaxel results in decreased expression of SIRT1 protein]; Aspirin inhibits the reaction [Sirolimus results in decreased expression of SIRT1 protein] |
CTD |
PMID:19520256 |
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NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
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G |
Slc16a1 |
solute carrier family 16 member 1 |
multiple interactions decreases expression |
ISO |
Aspirin affects the reaction [SLC16A1 protein results in increased uptake of Butyrates] Aspirin results in decreased expression of SLC16A1 mRNA |
CTD |
PMID:11906190 PMID:19023563 |
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NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611
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G |
Slc22a2 |
solute carrier family 22 member 2 |
affects response to substance |
ISO |
SLC22A2 polymorphism affects the susceptibility to Aspirin |
CTD |
PMID:21346370 |
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NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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G |
Slc22a25 |
solute carrier family 22, member 25 |
decreases activity |
ISO |
Aspirin results in decreased activity of SLC22A9 protein |
CTD |
PMID:12388633 |
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NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085
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G |
Slc22a6 |
solute carrier family 22 member 6 |
decreases activity |
ISO |
Aspirin results in decreased activity of SLC22A6 protein |
CTD |
PMID:12388633 |
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NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
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G |
Slc22a7 |
solute carrier family 22 member 7 |
decreases activity |
ISO |
Aspirin results in decreased activity of SLC22A7 protein |
CTD |
PMID:12388633 |
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NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921
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G |
Slc22a8 |
solute carrier family 22 member 8 |
increases expression |
ISO |
Aspirin results in increased expression of SLC22A8 mRNA |
CTD |
PMID:11906190 |
|
NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
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G |
Slc25a5 |
solute carrier family 25 member 5 |
increases expression |
EXP |
Aspirin results in increased expression of SLC25A5 mRNA |
CTD |
PMID:8554334 |
|
NCBI chr X:116,031,896...116,034,963
Ensembl chr X:116,031,803...116,034,967
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G |
Slc6a12 |
solute carrier family 6 member 12 |
affects response to substance |
ISO |
SLC6A12 polymorphism affects the susceptibility to Aspirin |
CTD |
PMID:20597903 |
|
NCBI chr 4:154,585,386...154,603,750
Ensembl chr 4:154,585,500...154,603,750
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G |
Slc7a11 |
solute carrier family 7 member 11 |
increases expression |
ISO |
Aspirin results in increased expression of SLC7A11 mRNA |
CTD |
PMID:32816093 |
|
NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
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G |
Slpi |
secretory leukocyte peptidase inhibitor |
decreases expression increases expression |
ISO |
Aspirin results in decreased expression of SLPI mRNA Aspirin results in increased expression of SLPI mRNA |
CTD |
PMID:15928584 PMID:32816093 |
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NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
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G |
Smap2 |
small ArfGAP2 |
affects response to substance |
ISO |
SMAP2 protein affects the susceptibility to Aspirin |
CTD |
PMID:20831471 |
|
NCBI chr 5:134,530,542...134,576,938
Ensembl chr 5:134,530,543...134,576,938
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G |
Smc4 |
structural maintenance of chromosomes 4 |
decreases expression |
ISO |
Aspirin results in decreased expression of SMC4 mRNA |
CTD |
PMID:11906190 |
|
NCBI chr 2:153,240,243...153,268,722
Ensembl chr 2:153,240,283...153,271,571
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G |
Smurf2 |
SMAD specific E3 ubiquitin protein ligase 2 |
increases expression |
ISO |
Aspirin results in increased expression of SMURF2 mRNA |
CTD |
PMID:15928584 |
|
NCBI chr10:91,761,798...91,862,485
Ensembl chr10:91,761,807...91,862,488
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G |
Snca |
synuclein alpha |
decreases expression |
ISO |
Aspirin results in decreased expression of SNCA mRNA |
CTD |
PMID:21353610 |
|
NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
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G |
Socs2 |
suppressor of cytokine signaling 2 |
increases expression multiple interactions |
ISO |
Aspirin results in increased expression of SOCS2 mRNA butyloxycarbonyl-phenylalanyl-leucyl-phenylalanyl-leucyl-phenylalanine inhibits the reaction [Aspirin results in increased expression of SOCS2 mRNA]; SOCS2 affects the reaction [Aspirin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]] |
CTD |
PMID:16415877 |
|
NCBI chr 7:30,006,360...30,045,161
Ensembl chr 7:30,008,578...30,043,548
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G |
Sod1 |
superoxide dismutase 1 |
multiple interactions |
ISO |
Aspirin inhibits the reaction [Cisplatin results in decreased activity of SOD1 protein] |
CTD |
PMID:37179038 |
|
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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G |
Sod2 |
superoxide dismutase 2 |
decreases expression multiple interactions increases expression |
ISO EXP |
Aspirin results in decreased expression of SOD2 mRNA rebamipide promotes the reaction [Aspirin results in increased expression of SOD2 protein] |
CTD |
PMID:21353610 PMID:22653900 |
|
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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G |
Spag6 |
sperm associated antigen 6 |
increases expression |
ISO |
Aspirin results in increased expression of SPAG6 mRNA |
CTD |
PMID:11906190 |
|
NCBI chr17:81,352,372...81,401,504
Ensembl chr17:81,349,084...81,401,501
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G |
Sparc |
secreted protein acidic and cysteine rich |
multiple interactions |
ISO |
Aspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of SPARC protein] |
CTD |
PMID:17303692 |
|
NCBI chr10:39,516,394...39,538,252
Ensembl chr10:39,516,406...39,538,396
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G |
Spp1 |
secreted phosphoprotein 1 |
affects expression |
EXP |
Aspirin affects the expression of SPP1 mRNA |
CTD |
PMID:12800193 |
|
NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
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G |
Sptan1 |
spectrin, alpha, non-erythrocytic 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of SPTAN1 mRNA |
CTD |
PMID:15456535 PMID:15928584 |
|
NCBI chr 3:13,241,164...13,306,047
Ensembl chr 3:13,241,217...13,306,046
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G |
Srpx |
sushi-repeat-containing protein, X-linked |
decreases expression |
ISO |
Aspirin results in decreased expression of SRPX mRNA |
CTD |
PMID:15456535 |
|
NCBI chr X:12,676,984...12,751,296
Ensembl chr X:12,566,645...12,747,882
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G |
Ssr3 |
signal sequence receptor subunit 3 |
increases expression |
ISO |
Aspirin results in increased expression of SSR3 mRNA |
CTD |
PMID:15456535 |
|
NCBI chr 2:149,605,005...149,625,069
Ensembl chr 2:149,605,005...149,625,132
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G |
Stambp |
Stam binding protein |
increases expression |
ISO |
Aspirin results in increased expression of STAMBP mRNA |
CTD |
PMID:15928584 |
|
NCBI chr 4:116,055,563...116,083,563
Ensembl chr 4:116,056,057...116,080,543
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G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions decreases phosphorylation decreases expression |
ISO |
IL6 protein inhibits the reaction [Aspirin results in decreased expression of STAT3 protein modified form] Aspirin results in decreased phosphorylation of STAT3 protein Aspirin results in decreased expression of STAT3 mRNA; Aspirin results in decreased expression of STAT3 protein modified form |
CTD |
PMID:11906190 PMID:19595669 PMID:20886344 |
|
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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G |
Stat5b |
signal transducer and activator of transcription 5B |
decreases expression |
ISO |
Aspirin results in decreased expression of STAT5B mRNA |
CTD |
PMID:15928584 |
|
NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668
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G |
Stat6 |
signal transducer and activator of transcription 6 |
multiple interactions |
ISO |
Aspirin inhibits the reaction [IL4 results in increased activity of STAT6 protein]; Aspirin inhibits the reaction [IL4 results in increased phosphorylation of STAT6 protein] |
CTD |
PMID:19767084 |
|
NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495
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G |
Stk10 |
serine/threonine kinase 10 |
affects response to substance |
ISO |
STK10 polymorphism affects the susceptibility to Aspirin |
CTD |
PMID:21905501 |
|
NCBI chr10:17,117,860...17,212,065
Ensembl chr10:17,117,878...17,212,061
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G |
Strn4 |
striatin 4 |
increases expression |
ISO |
Aspirin results in increased expression of STRN4 mRNA |
CTD |
PMID:11906190 |
|
NCBI chr 1:77,482,267...77,511,862
Ensembl chr 1:77,482,094...77,511,858
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G |
Stxbp1 |
syntaxin binding protein 1 |
affects expression |
EXP |
Aspirin affects the expression of STXBP1 mRNA |
CTD |
PMID:12800193 |
|
NCBI chr 3:16,076,725...16,138,431
Ensembl chr 3:16,076,391...16,138,369
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G |
Sumo1 |
small ubiquitin-like modifier 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of SUMO1 mRNA |
CTD |
PMID:11906190 |
|
NCBI chr 9:61,078,790...61,108,697
Ensembl chr 9:61,077,435...61,108,761
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G |
Sumo3 |
small ubiquitin-like modifier 3 |
increases expression |
ISO |
Aspirin results in increased expression of SUMO3 mRNA |
CTD |
PMID:11906190 |
|
NCBI chr20:11,010,140...11,020,850
Ensembl chr20:11,007,148...11,020,877 Ensembl chr20:11,007,148...11,020,877
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G |
Sun2 |
Sad1 and UNC84 domain containing 2 |
increases expression |
ISO |
Aspirin results in increased expression of SUN2 mRNA |
CTD |
PMID:11906190 |
|
NCBI chr 7:111,275,374...111,292,565
Ensembl chr 7:111,275,380...111,292,553
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G |
Tacc3 |
transforming, acidic coiled-coil containing protein 3 |
decreases expression |
ISO |
Aspirin results in decreased expression of TACC3 mRNA |
CTD |
PMID:15928584 |
|
NCBI chr14:77,051,209...77,065,343
Ensembl chr14:77,051,215...77,065,219
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G |
Taf6 |
TATA-box binding protein associated factor 6 |
decreases expression |
ISO |
Aspirin results in decreased expression of TAF6 mRNA |
CTD |
PMID:11906190 |
|
NCBI chr12:17,055,864...17,064,244
Ensembl chr12:17,055,873...17,064,247
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G |
Tap2 |
transporter 2, ATP binding cassette subfamily B member |
affects response to substance |
ISO |
TAP2 SNP affects the susceptibility to Aspirin |
CTD |
PMID:21796142 |
|
NCBI chr20:4,636,347...4,650,387
Ensembl chr20:4,636,357...4,650,407
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G |
Tbc1d10b |
TBC1 domain family, member 10b |
increases expression |
ISO |
Aspirin results in increased expression of TBC1D10B mRNA |
CTD |
PMID:11906190 |
|
NCBI chr 1:181,814,972...181,826,628
Ensembl chr 1:181,814,972...181,826,628
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G |
Tbl1x |
transducin (beta)-like 1 X-linked |
decreases expression |
ISO |
Aspirin results in decreased expression of TBL1X mRNA |
CTD |
PMID:15928584 |
|
NCBI chr X:41,574,558...41,731,117
Ensembl chr X:41,576,047...41,731,101
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G |
Tbx21 |
T-box transcription factor 21 |
affects response to substance |
ISO |
TBX21 SNP affects the susceptibility to Aspirin |
CTD |
PMID:15806396 |
|
NCBI chr10:82,082,322...82,098,831
Ensembl chr10:82,082,322...82,098,831
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G |
Tbxa2r |
thromboxane A2 receptor |
affects response to substance decreases response to substance |
ISO |
TBXA2R gene SNP affects the susceptibility to Aspirin; TBXA2R polymorphism affects the susceptibility to Aspirin TBXA2R SNP results in decreased susceptibility to Aspirin |
CTD |
PMID:17245331 PMID:20485159 PMID:21070398 |
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NCBI chr 7:8,383,347...8,390,753
Ensembl chr 7:8,383,378...8,388,176
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G |
Tbxas1 |
thromboxane A synthase 1 |
affects response to substance |
ISO |
TBXAS1 polymorphism affects the susceptibility to Aspirin |
CTD |
PMID:21449675 |
|
NCBI chr 4:67,664,963...67,837,096
Ensembl chr 4:67,665,007...67,837,096
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G |
Tcf4 |
transcription factor 4 |
multiple interactions decreases activity |
ISO |
TCF4 protein promotes the reaction [Aspirin results in increased susceptibility to TNFSF10 protein] Aspirin results in decreased activity of TCF4 protein |
CTD |
PMID:11593435 PMID:21171083 |
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NCBI chr18:62,941,739...63,288,126
Ensembl chr18:62,943,782...63,284,425
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G |
Tcirg1 |
T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 |
increases expression |
ISO |
Aspirin results in increased expression of TCIRG1 mRNA |
CTD |
PMID:11906190 |
|
NCBI chr 1:201,127,034...201,138,787
Ensembl chr 1:201,127,034...201,138,742
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G |
Tert |
telomerase reverse transcriptase |
increases expression |
ISO |
Aspirin results in increased expression of TERT mRNA |
CTD |
PMID:20457246 |
|
NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561
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G |
Tf |
transferrin |
multiple interactions |
ISO |
Aspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of TF protein] |
CTD |
PMID:17303692 |
|
NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
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G |
Tfam |
transcription factor A, mitochondrial |
multiple interactions |
ISO |
Aspirin inhibits the reaction [Cisplatin results in decreased expression of TFAM protein] |
CTD |
PMID:37179038 |
|
NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292
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G |
Tfe3 |
transcription factor binding to IGHM enhancer 3 |
decreases expression |
ISO |
Aspirin results in decreased expression of TFE3 mRNA |
CTD |
PMID:15928584 |
|
NCBI chr X:14,729,547...14,742,830
Ensembl chr X:14,729,550...14,742,571
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G |
Tff2 |
trefoil factor 2 |
multiple interactions |
EXP |
[Aspirin co-treated with Hydrochloric Acid] results in increased expression of TFF2 mRNA |
CTD |
PMID:9726391 |
|
NCBI chr20:9,215,750...9,219,619
Ensembl chr20:9,215,761...9,219,619
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G |
Tfg |
trafficking from ER to golgi regulator |
increases expression |
ISO |
Aspirin results in increased expression of TFG mRNA |
CTD |
PMID:15928584 |
|
NCBI chr11:43,885,542...43,911,976
Ensembl chr11:43,885,661...43,911,976
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G |
Tgfa |
transforming growth factor alpha |
multiple interactions decreases expression |
EXP |
[Aspirin co-treated with Hydrochloric Acid] results in increased expression of TGFA mRNA Aspirin results in decreased expression of TGFA mRNA |
CTD |
PMID:9726391 PMID:12231391 |
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NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894
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G |
Tgfb1 |
transforming growth factor, beta 1 |
decreases expression multiple interactions increases response to substance |
ISO EXP |
Aspirin results in decreased expression of TGFB1 mRNA Aspirin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; Aspirin inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA] TGFB1 promoter SNP results in increased susceptibility to Aspirin |
CTD |
PMID:12566377 PMID:14586741 PMID:15928584 PMID:19138248 PMID:21360558 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Tgif1 |
TGFB-induced factor homeobox 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of TGIF1 mRNA |
CTD |
PMID:15928584 |
|
NCBI chr 9:110,748,094...110,757,714
Ensembl chr 9:110,720,921...110,757,802
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G |
Thbs1 |
thrombospondin 1 |
increases expression multiple interactions |
ISO |
Aspirin results in increased expression of THBS1 mRNA Aspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of THBS1 protein] |
CTD |
PMID:15928584 PMID:17303692 |
|
NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440
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G |
Timm17b |
translocase of inner mitochondrial membrane 17b |
increases expression |
ISO |
Aspirin results in increased expression of TIMM17B mRNA |
CTD |
PMID:11906190 |
|
NCBI chr X:14,596,330...14,603,491
Ensembl chr X:14,594,577...14,603,416
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G |
Timp1 |
TIMP metallopeptidase inhibitor 1 |
increases expression increases secretion |
ISO |
Aspirin results in increased expression of TIMP1 mRNA Aspirin results in increased secretion of TIMP1 protein |
CTD |
PMID:18971601 PMID:19462226 |
|
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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G |
Timp2 |
TIMP metallopeptidase inhibitor 2 |
decreases expression increases expression |
ISO |
Aspirin results in decreased expression of TIMP2 mRNA Aspirin results in increased expression of TIMP2 mRNA |
CTD |
PMID:15928584 PMID:18971601 |
|
NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611
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G |
Tlr3 |
toll-like receptor 3 |
affects response to substance |
ISO |
TLR3 polymorphism affects the susceptibility to Aspirin |
CTD |
PMID:21461252 |
|
NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545
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G |
Tmed9 |
transmembrane p24 trafficking protein 9 |
increases expression |
ISO |
Aspirin results in increased expression of TMED9 mRNA |
CTD |
PMID:11906190 |
|
NCBI chr17:9,029,646...9,034,160
Ensembl chr17:9,029,646...9,034,176
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G |
Tmem205 |
transmembrane protein 205 |
increases expression |
EXP |
Aspirin results in increased expression of TMEM205 mRNA |
CTD |
PMID:12800193 |
|
NCBI chr 8:20,452,092...20,458,011
Ensembl chr 8:20,452,092...20,457,828
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G |
Tmod4 |
tropomodulin 4 |
increases expression |
ISO |
Aspirin results in increased expression of TMOD4 mRNA |
CTD |
PMID:11906190 |
|
NCBI chr 2:182,695,709...182,700,540
Ensembl chr 2:182,695,709...182,700,540
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G |
Tmsb4x |
thymosin beta 4, X-linked |
increases expression |
ISO |
Aspirin results in increased expression of TMSB4X mRNA |
CTD |
PMID:15928584 |
|
NCBI chr X:27,144,666...27,146,667
Ensembl chr X:27,128,610...27,146,667 Ensembl chr10:27,128,610...27,146,667
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G |
Tnf |
tumor necrosis factor |
multiple interactions increases expression decreases expression affects secretion affects response to substance |
ISO EXP |
[Aspirin co-treated with IL1A] results in increased expression of TNF mRNA; Aspirin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Aspirin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Aspirin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Aspirin inhibits the reaction [TNF protein results in increased activity of CHUK protein]; Aspirin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Aspirin inhibits the reaction [TNF protein results in increased activity of RELA protein]; Aspirin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Aspirin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Aspirin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; Aspirin inhibits the reaction [TNF results in increased degradation of NFKBIA protein]; Aspirin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]; Aspirin inhibits the reaction [TNF results in increased expression of CX3CL1 mRNA]; Aspirin inhibits the reaction [TNF results in increased expression of CX3CL1 protein]; Aspirin inhibits the reaction [TNF results in increased expression of CXCL8 mRNA]; Aspirin inhibits the reaction [TNF results in increased expression of PTGS2 mRNA]; Aspirin inhibits the reaction [TNF results in increased expression of PTGS2 protein]; Aspirin inhibits the reaction [TNF results in increased phosphorylation of NFKBIA protein]; Aspirin inhibits the reaction [TNF results in increased phosphorylation of NFKBIB protein]; Aspirin inhibits the reaction [TNF results in increased secretion of CCL2 protein]; Aspirin inhibits the reaction [TNF results in increased secretion of CXCL8 protein]; Aspirin promotes the reaction [Salmonella Vaccines results in increased expression of TNF protein] Aspirin results in increased expression of TNF protein [Telmisartan co-treated with Aspirin] inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Ampicillin inhibits the reaction [Aspirin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF mRNA]]; Ampicillin inhibits the reaction [Aspirin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]]; Aspirin inhibits the reaction [[Lipopolysaccharides co-treated with TNF protein co-treated with IL1B protein] results in increased activity of NFKB1 protein]; Aspirin inhibits the reaction [[Lipopolysaccharides co-treated with TNF protein co-treated with IL1B protein] results in increased activity of RELA protein]; Aspirin inhibits the reaction [Azoxymethane results in increased expression of TNF mRNA]; Aspirin inhibits the reaction [Oxaliplatin results in increased expression of TNF mRNA]; Aspirin inhibits the reaction [Oxaliplatin results in increased expression of TNF protein]; Aspirin inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Aspirin promotes the reaction [Acetic Acid results in increased expression of TNF protein]; Aspirin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF mRNA]; Aspirin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]; Bee Venoms inhibits the reaction [Aspirin results in increased expression of TNF protein]; lipopolysaccharide, Helicobacter pylori inhibits the reaction [Aspirin results in increased expression of TNF protein]; Ranitidine inhibits the reaction [Aspirin results in increased expression of TNF protein] Aspirin results in decreased expression of TNF mRNA [Aspirin co-treated with Lipopolysaccharides] results in increased secretion of TNF protein; [Pertussis Toxin co-treated with Dithiothreitol] inhibits the reaction [Aspirin inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]]; [Pertussis Toxin co-treated with Dithiothreitol] inhibits the reaction [Aspirin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; Aspirin inhibits the reaction [Acetaminophen results in increased expression of TNF mRNA]; Aspirin inhibits the reaction [Benzo(a)pyrene results in increased expression of TNF protein]; Aspirin inhibits the reaction [Cisplatin results in increased expression of TNF mRNA]; Aspirin inhibits the reaction [Cisplatin results in increased expression of TNF protein]; Aspirin inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]; Aspirin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Aspirin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Aspirin inhibits the reaction [TNF protein results in increased abundance of Dinoprostone]; Aspirin inhibits the reaction [TNF protein results in increased secretion of Dinoprostone]; SOCS2 affects the reaction [Aspirin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]] Aspirin affects the secretion of TNF protein TNF gene SNP affects the susceptibility to Aspirin; TNF polymorphism affects the susceptibility to Aspirin |
CTD |
PMID:9281604 PMID:10328874 PMID:11376495 PMID:11826407 PMID:12045164 PMID:14742690 PMID:15024038 PMID:15036249 PMID:15136050 PMID:15379866 PMID:15489888 PMID:16413386 PMID:16415877 PMID:17328244 PMID:17516296 PMID:19164858 PMID:19493461 PMID:20043115 PMID:20223228 PMID:20485159 PMID:21353610 PMID:21893697 PMID:22039321 PMID:30885738 PMID:35537566 PMID:35574720 PMID:37179038 PMID:37364758 More...
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnfaip6 |
TNF alpha induced protein 6 |
increases expression decreases expression |
ISO |
Aspirin results in increased expression of TNFAIP6 mRNA Aspirin results in decreased expression of TNFAIP6 mRNA |
CTD |
PMID:15928584 PMID:32816093 |
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NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649
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Tnfrsf10b |
TNF receptor superfamily member 10b |
multiple interactions |
EXP |
Aspirin inhibits the reaction [Azoxymethane results in increased expression of TNFRSF10B mRNA] |
CTD |
PMID:20043115 |
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NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467
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Tnfrsf1a |
TNF receptor superfamily member 1A |
increases expression |
ISO |
Aspirin results in increased expression of TNFRSF1A mRNA |
CTD |
PMID:20457246 |
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NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
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Tnfrsf25 |
TNF receptor superfamily member 25 |
increases expression |
ISO |
Aspirin results in increased expression of TNFRSF25 mRNA |
CTD |
PMID:20457246 |
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NCBI chr 5:162,621,669...162,626,341
Ensembl chr 5:162,622,075...162,626,341
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Tnfsf10 |
TNF superfamily member 10 |
multiple interactions increases response to substance |
ISO EXP |
[Aspirin co-treated with TNFSF10 protein] results in decreased expression of BIRC5 protein; [Aspirin co-treated with TNFSF10 protein] results in increased activity of CASP8 protein; [Aspirin co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP3 protein; [Aspirin co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP8 protein; [Aspirin co-treated with TNFSF10 protein] results in increased cleavage of BID protein; [Aspirin co-treated with TNFSF10 protein] results in increased cleavage of PARP1 protein; [TNFSF10 protein co-treated with Aspirin] results in increased cleavage of and results in increased activity of CASP3 protein; [TNFSF10 protein co-treated with Aspirin] results in increased cleavage of and results in increased activity of CASP9 protein; [TNFSF10 protein co-treated with Aspirin] results in increased cleavage of CASP8 protein; Aspirin promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]; BCL2 protein inhibits the reaction [[TNFSF10 protein co-treated with Aspirin] results in increased cleavage of and results in increased activity of CASP3 protein]; BCL2 protein inhibits the reaction [[TNFSF10 protein co-treated with Aspirin] results in increased cleavage of and results in increased activity of CASP9 protein]; BCL2 protein inhibits the reaction [Aspirin promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; TCF4 protein promotes the reaction [Aspirin results in increased susceptibility to TNFSF10 protein] Aspirin inhibits the reaction [Azoxymethane results in increased expression of TNFSF10 mRNA] |
CTD |
PMID:16199534 PMID:18483385 PMID:20043115 PMID:21171083 |
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NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
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Tnni3 |
troponin I3, cardiac type |
increases expression |
ISO |
Aspirin results in increased expression of TNNI3 mRNA |
CTD |
PMID:11906190 |
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NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580
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Tns3 |
tensin 3 |
increases expression |
ISO |
Aspirin results in increased expression of TNS3 mRNA |
CTD |
PMID:11906190 |
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NCBI chr14:83,173,649...83,405,671
Ensembl chr14:83,173,649...83,405,998
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Tob1 |
transducer of ErbB-2.1 |
decreases expression |
ISO |
Aspirin results in decreased expression of TOB1 mRNA |
CTD |
PMID:11906190 |
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NCBI chr10:79,163,093...79,165,131
Ensembl chr10:79,160,154...79,165,215
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Top3b |
DNA topoisomerase III beta |
increases expression |
ISO |
Aspirin results in increased expression of TOP3B mRNA |
CTD |
PMID:11906190 |
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NCBI chr11:84,097,018...84,125,474
Ensembl chr11:84,097,026...84,125,392
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Tp53 |
tumor protein p53 |
increases acetylation multiple interactions increases expression |
ISO |
Aspirin results in increased acetylation of TP53 protein Aspirin inhibits the reaction [sodium bichromate results in increased expression of TP53 protein] Aspirin results in increased expression of TRP53 protein Aspirin results in increased expression of TP53 protein |
CTD |
PMID:10942736 PMID:12535653 PMID:16880202 PMID:19212664 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Tp53i13 |
tumor protein p53 inducible protein 13 |
increases expression |
ISO |
Aspirin results in increased expression of TP53I13 mRNA |
CTD |
PMID:11906190 |
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NCBI chr10:62,356,722...62,363,122
Ensembl chr10:62,356,722...62,361,343
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Tpd52l2 |
TPD52 like 2 |
decreases expression |
ISO |
Aspirin results in decreased expression of TPD52L2 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 3:168,598,449...168,618,201
Ensembl chr 3:168,594,609...168,619,762
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Tra2b |
transformer 2 beta |
increases expression decreases expression |
ISO EXP |
Aspirin results in increased expression of TRA2B mRNA Aspirin results in decreased expression of TRA2B mRNA |
CTD |
PMID:12800193 PMID:15928584 |
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NCBI chr11:78,788,880...78,807,252
Ensembl chr11:78,788,884...78,807,249
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Traf6 |
TNF receptor associated factor 6 |
increases expression |
ISO |
Aspirin results in increased expression of TRAF6 mRNA |
CTD |
PMID:11906190 |
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NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507
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Trappc6a |
trafficking protein particle complex subunit 6A |
increases expression |
ISO |
Aspirin results in increased expression of TRAPPC6A mRNA |
CTD |
PMID:11906190 |
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NCBI chr 1:79,158,587...79,165,502
Ensembl chr 1:79,158,529...79,165,493
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Trim21 |
tripartite motif-containing 21 |
decreases expression |
ISO |
Aspirin results in decreased expression of TRIM21 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 1:156,964,896...156,987,504
Ensembl chr 1:156,964,913...156,987,440
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Trit1 |
tRNA isopentenyltransferase 1 |
increases expression |
ISO |
Aspirin results in increased expression of TRIT1 mRNA |
CTD |
PMID:11906190 |
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NCBI chr 5:135,293,472...135,341,522
Ensembl chr 5:135,295,330...135,338,764
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Trpm4 |
transient receptor potential cation channel, subfamily M, member 4 |
increases expression |
ISO |
Aspirin results in increased expression of TRPM4 mRNA |
CTD |
PMID:11906190 |
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NCBI chr 1:95,781,805...95,812,095
Ensembl chr 1:95,782,000...95,812,532
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Tsnax |
translin-associated factor X |
increases expression |
ISO |
Aspirin results in increased expression of TSNAX mRNA |
CTD |
PMID:11906190 |
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NCBI chr19:52,975,848...52,989,886
Ensembl chr19:52,975,659...52,989,878
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Tspan3 |
tetraspanin 3 |
decreases expression |
ISO |
Aspirin results in decreased expression of TSPAN3 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 8:56,546,067...56,569,815
Ensembl chr 8:56,546,069...56,569,880
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Tuba1a |
tubulin, alpha 1A |
decreases expression |
ISO |
Aspirin results in decreased expression of TUBA1A mRNA |
CTD |
PMID:15928584 |
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NCBI chr 7:130,113,214...130,116,880
Ensembl chr 7:130,081,032...130,196,186
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Txnrd1 |
thioredoxin reductase 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of TXNRD1 mRNA |
CTD |
PMID:11906190 |
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NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
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Tyk2 |
tyrosine kinase 2 |
decreases expression |
ISO |
Aspirin results in decreased expression of TYK2 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 8:19,641,881...19,667,157
Ensembl chr 8:19,641,884...19,667,044
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Tymp |
thymidine phosphorylase |
multiple interactions decreases expression |
ISO |
Aspirin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TYMP mRNA] Aspirin results in decreased expression of TYMP mRNA |
CTD |
PMID:14573775 PMID:15456535 |
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NCBI chr 7:120,438,768...120,444,088
Ensembl chr 7:120,438,770...120,443,874 Ensembl chr 7:120,438,770...120,443,874
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Uba2 |
ubiquitin-like modifier activating enzyme 2 |
increases expression |
ISO |
Aspirin results in increased expression of UBA2 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 1:86,775,239...86,802,685
Ensembl chr 1:86,775,244...86,802,682
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Ube2a |
ubiquitin-conjugating enzyme E2A |
increases expression |
ISO |
Aspirin results in increased expression of UBE2A mRNA |
CTD |
PMID:15928584 |
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NCBI chr X:116,114,339...116,125,076
Ensembl chr X:116,113,875...116,125,070
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Ube2b |
ubiquitin-conjugating enzyme E2B |
increases expression |
EXP |
Aspirin results in increased expression of UBE2B mRNA |
CTD |
PMID:12800193 |
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NCBI chr10:36,248,434...36,263,379
Ensembl chr10:36,248,438...36,264,665
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Ube2k |
ubiquitin-conjugating enzyme E2K |
increases expression |
ISO |
Aspirin results in increased expression of UBE2K mRNA |
CTD |
PMID:11906190 |
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NCBI chr14:42,658,016...42,718,899
Ensembl chr14:42,658,016...42,718,630
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Ube3c |
ubiquitin protein ligase E3C |
affects response to substance |
ISO |
UBE3C polymorphism affects the susceptibility to Aspirin |
CTD |
PMID:20934631 |
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NCBI chr 4:5,648,932...5,749,922
Ensembl chr 4:5,648,690...5,750,011
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Ube4a |
ubiquitination factor E4A |
increases expression |
ISO |
Aspirin results in increased expression of UBE4A mRNA |
CTD |
PMID:15928584 |
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NCBI chr 8:45,236,022...45,278,129
Ensembl chr 8:45,236,026...45,278,038
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Ubtd1 |
ubiquitin domain containing 1 |
increases expression |
ISO |
Aspirin results in increased expression of UBTD1 mRNA |
CTD |
PMID:11906190 |
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NCBI chr 1:240,794,570...240,845,795
Ensembl chr 1:240,794,570...240,845,788
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Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
increases response to substance |
EXP |
UGT1A1 gene mutant form results in increased susceptibility to Aspirin; UGT1A1 protein mutant form results in increased susceptibility to Aspirin |
CTD |
PMID:3864191 PMID:6776978 |
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NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Ugt1a2 |
UDP glucuronosyltransferase 1 family, polypeptide A2 |
increases glucuronidation |
ISO |
UGT1A3 protein results in increased glucuronidation of Aspirin |
CTD |
PMID:15117964 |
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NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Ugt1a6 |
UDP glucuronosyltransferase family 1 member A6 |
affects expression |
EXP |
Aspirin affects the expression of UGT1A6 mRNA |
CTD |
PMID:12800193 |
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NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Ung |
uracil-DNA glycosylase |
increases expression |
ISO |
Aspirin results in increased expression of UNG mRNA |
CTD |
PMID:11906190 |
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NCBI chr12:42,485,276...42,494,217
Ensembl chr12:42,485,276...42,494,206
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Uqcrc2 |
ubiquinol cytochrome c reductase core protein 2 |
multiple interactions |
ISO |
Aspirin inhibits the reaction [Cisplatin results in decreased expression of UQCRC2 mRNA] |
CTD |
PMID:37179038 |
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NCBI chr 1:175,167,933...175,198,499
Ensembl chr 1:175,167,894...175,199,453
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Usp15 |
ubiquitin specific peptidase 15 |
increases expression |
ISO |
Aspirin results in increased expression of USP15 mRNA |
CTD |
PMID:11906190 |
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NCBI chr 7:58,756,714...58,848,778
Ensembl chr 7:58,756,872...58,848,721
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Vamp1 |
vesicle-associated membrane protein 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of VAMP1 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 4:158,012,634...158,019,350
Ensembl chr 4:158,012,663...158,019,349
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Vav1 |
vav guanine nucleotide exchange factor 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of VAV1 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 9:2,161,985...2,209,951
Ensembl chr 9:2,157,900...2,208,937
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Vcam1 |
vascular cell adhesion molecule 1 |
decreases expression |
ISO EXP |
Aspirin results in decreased expression of VCAM1 mRNA Aspirin results in decreased expression of VCAM1 protein |
CTD |
PMID:15456535 PMID:16310244 |
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NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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Vcl |
vinculin |
decreases expression |
ISO |
Aspirin results in decreased expression of VCL mRNA |
CTD |
PMID:11906190 |
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NCBI chr15:3,265,776...3,355,586
Ensembl chr15:3,265,815...3,355,606
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Vdac1 |
voltage-dependent anion channel 1 |
affects expression |
EXP |