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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:carotenoid beta-end derivative
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Accession:CHEBI:139120 term browser browse the term
Definition:Any carotenoid derivative with an beta-end group
Synonyms:related_synonym: Formula=C19H27R;   SMILES=C1(=C(CCCC1(C)C)C)/C=C/C(=C/C=C/C(=C/*)/C)/C;   a carotenoid beta-end derivative
 xref: MetaCyc:Carotenoid-beta-end-group



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alpha-carotene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MGMT O-6-methylguanine-DNA methyltransferase affects response to substance EXP MGMT gene SNP affects the susceptibility to alpha-carotene CTD PMID:16014702 NCBI chr10:129,467,241...129,770,983
Ensembl chr10:129,467,190...129,770,983
JBrowse link
astaxanthin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AIFM1 apoptosis inducing factor mitochondria associated 1 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of AIFM1 mRNA] CTD PMID:16964424 NCBI chr  X:130,129,362...130,165,841
Ensembl chr  X:130,124,666...130,165,879
JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions ISO astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased phosphorylation of AKT1 protein] CTD PMID:33008094 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759
JBrowse link
G ALB albumin multiple interactions ISO astaxanthine inhibits the reaction [thiacloprid results in decreased expression of ALB protein] CTD PMID:34564187 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
JBrowse link
G APP amyloid beta precursor protein multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of APP mRNA] CTD PMID:16964424 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128
JBrowse link
G ARG1 arginase 1 multiple interactions ISO astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of ARG1 mRNA] CTD PMID:33008094 NCBI chr 6:131,573,226...131,584,329
Ensembl chr 6:131,470,832...131,584,332
JBrowse link
G ATG12 autophagy related 12 multiple interactions EXP astaxanthine inhibits the reaction [bisphenol A results in increased expression of ATG12 mRNA] CTD PMID:34439521 NCBI chr 5:115,828,200...115,841,565
Ensembl chr 5:115,828,200...115,841,837
JBrowse link
G ATG14 autophagy related 14 multiple interactions EXP astaxanthine inhibits the reaction [bisphenol A results in increased expression of ATG14 mRNA] CTD PMID:34439521 NCBI chr14:55,366,391...55,411,830
Ensembl chr14:55,366,391...55,411,830
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions EXP astaxanthine inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX mRNA] CTD PMID:33212048 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BECN1 beclin 1 multiple interactions EXP astaxanthine inhibits the reaction [bisphenol A results in increased expression of BECN1 mRNA]; astaxanthine inhibits the reaction [bisphenol A results in increased expression of BECN1 protein] CTD PMID:34439521 NCBI chr17:42,810,132...42,824,282
Ensembl chr17:42,810,134...42,833,350
JBrowse link
G C1QA complement C1q A chain decreases expression ISO astaxanthine results in decreased expression of C1QA mRNA CTD PMID:19555370 NCBI chr 1:22,636,463...22,639,678
Ensembl chr 1:22,635,077...22,639,678
JBrowse link
G CASP3 caspase 3 multiple interactions EXP astaxanthine inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 mRNA] CTD PMID:33212048 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
JBrowse link
G CAT catalase multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of CAT mRNA]
astaxanthine inhibits the reaction [thiacloprid results in decreased activity of CAT protein]
CTD PMID:16964424 PMID:34564187 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CNTD1 cyclin N-terminal domain containing 1 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of CNTD1 mRNA] CTD PMID:16964424 NCBI chr17:42,798,785...42,811,587
Ensembl chr17:42,798,800...42,811,587
JBrowse link
G COL2A1 collagen type II alpha 1 chain multiple interactions ISO astaxanthine inhibits the reaction [IL1B protein results in decreased expression of COL2A1 protein] CTD PMID:36084724 NCBI chr12:47,972,967...48,006,212
Ensembl chr12:47,972,967...48,004,554
JBrowse link
G COX15 cytochrome c oxidase assembly homolog COX15 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX15 mRNA] CTD PMID:16964424 NCBI chr10:99,694,293...99,732,127
Ensembl chr10:99,710,868...99,732,127
JBrowse link
G COX5A cytochrome c oxidase subunit 5A multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX5A mRNA] CTD PMID:16964424 NCBI chr15:74,919,791...74,938,073
Ensembl chr15:74,919,791...74,938,083
JBrowse link
G COX5B cytochrome c oxidase subunit 5B multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX5B mRNA] CTD PMID:16964424 NCBI chr 2:97,646,062...97,648,383
Ensembl chr 2:97,646,062...97,648,383
JBrowse link
G COX6B1 cytochrome c oxidase subunit 6B1 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX6B1 mRNA] CTD PMID:16964424 NCBI chr19:35,648,323...35,658,782
Ensembl chr19:35,648,323...35,658,782
JBrowse link
G COX6C cytochrome c oxidase subunit 6C multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX6C mRNA] CTD PMID:16964424 NCBI chr 8:99,877,865...99,893,707
Ensembl chr 8:99,873,200...99,893,707
JBrowse link
G CTSS cathepsin S decreases expression ISO astaxanthine results in decreased expression of CTSS mRNA CTD PMID:19555370 NCBI chr 1:150,730,188...150,765,778
Ensembl chr 1:150,730,079...150,765,957
JBrowse link
G CYBB cytochrome b-245 beta chain multiple interactions
decreases expression
ISO astaxanthine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CYBB mRNA]; astaxanthine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CYBB protein]; tin protoporphyrin IX inhibits the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CYBB mRNA]]
astaxanthine results in decreased expression of CYBB mRNA
CTD PMID:23272707 NCBI chr  X:37,780,059...37,813,461
Ensembl chr  X:37,780,018...37,813,461
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions
increases expression
ISO astaxanthine results in increased expression of and results in increased activity of CYP1A1 protein
astaxanthine results in increased expression of CYP1A1 mRNA
CTD PMID:21414371 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G FOXO3 forkhead box O3 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of FOXO3 mRNA] CTD PMID:16964424 NCBI chr 6:108,559,825...108,684,774
Ensembl chr 6:108,559,835...108,684,774
JBrowse link
G G6PD glucose-6-phosphate dehydrogenase increases activity
multiple interactions
ISO astaxanthine results in increased activity of G6PD protein
[Cadmium co-treated with astaxanthine] results in decreased activity of G6PD protein
CTD PMID:28665548 PMID:29975440 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,517,825...154,547,572
JBrowse link
G GFAP glial fibrillary acidic protein decreases expression ISO astaxanthine results in decreased expression of GFAP mRNA CTD PMID:19555370 NCBI chr17:44,903,159...44,915,500
Ensembl chr17:44,903,159...44,916,937
JBrowse link
G GJA1 gap junction protein alpha 1 increases expression
multiple interactions
ISO astaxanthine results in increased expression of GJA1 protein
2-chloro-5-nitrobenzanilide inhibits the reaction [astaxanthine results in increased expression of GJA1 protein]; astaxanthine promotes the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of GJA1 protein]
CTD PMID:16091010 NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727
JBrowse link
G GNA13 G protein subunit alpha 13 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GNA13 mRNA] CTD PMID:16964424 NCBI chr17:65,009,289...65,056,740
Ensembl chr17:65,009,289...65,056,740
JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions ISO astaxanthine inhibits the reaction [thiacloprid results in increased expression of GPT protein] CTD PMID:34564187 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174
JBrowse link
G GPX3 glutathione peroxidase 3 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GPX3 mRNA] CTD PMID:16964424 NCBI chr 5:151,020,591...151,028,988
Ensembl chr 5:151,020,591...151,028,988
JBrowse link
G GPX4 glutathione peroxidase 4 multiple interactions
increases expression
ISO
EXP
astaxanthine inhibits the reaction [IL1B protein results in decreased expression of GPX4 protein]
astaxanthine results in increased expression of GPX4 protein
astaxanthine inhibits the reaction [erastin results in decreased expression of GPX4 protein]
CTD PMID:36084724 PMID:37648051 NCBI chr19:1,103,994...1,106,779
Ensembl chr19:1,103,982...1,106,791
JBrowse link
G GRIN1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions ISO [mithramycin A co-treated with astaxanthine] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein]; astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 mRNA]; astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein]; astaxanthine promotes the reaction [mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 mRNA]]; astaxanthine promotes the reaction [mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein]]; mithramycin A promotes the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 mRNA]]; mithramycin A promotes the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein]] CTD PMID:23538867 NCBI chr 9:137,139,154...137,168,756
Ensembl chr 9:137,138,346...137,168,756
JBrowse link
G GRN granulin precursor multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GRN mRNA] CTD PMID:16964424 NCBI chr17:44,345,302...44,353,106
Ensembl chr17:44,345,246...44,353,106
JBrowse link
G GSR glutathione-disulfide reductase multiple interactions ISO astaxanthine inhibits the reaction [Cadmium results in decreased activity of GSR protein] CTD PMID:29975440 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G GSTM2 glutathione S-transferase mu 2 multiple interactions
increases expression
EXP [astaxanthine co-treated with Docosahexaenoic Acids] results in increased expression of GSTM2 mRNA; [astaxanthine co-treated with Eicosapentaenoic Acid] results in increased expression of GSTM2 mRNA
astaxanthine results in increased expression of GSTM2 mRNA
CTD PMID:24157545 NCBI chr 1:109,668,057...109,683,997
Ensembl chr 1:109,668,022...109,709,551
JBrowse link
G HMGB1 high mobility group box 1 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of HMGB1 mRNA]
astaxanthine inhibits the reaction [thiacloprid results in increased expression of HMGB1 mRNA]
CTD PMID:16964424 PMID:34564187 NCBI chr13:30,456,704...30,617,597
Ensembl chr13:30,456,704...30,617,597
JBrowse link
G HMOX1 heme oxygenase 1 increases expression
multiple interactions
decreases expression
ISO
EXP
astaxanthine results in increased expression of HMOX1 protein
astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of HMOX1 mRNA]; astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of HMOX1 protein]
astaxanthine results in decreased expression of HMOX1 mRNA
[astaxanthine co-treated with Cyclophosphamide] results in increased expression of HMOX1 protein; astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]; astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]; tin protoporphyrin IX inhibits the reaction [astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]]; tin protoporphyrin IX inhibits the reaction [astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]]
astaxanthine results in increased expression of HMOX1 mRNA
[astaxanthine co-treated with Docosahexaenoic Acids] results in increased expression of HMOX1 mRNA; [astaxanthine co-treated with Eicosapentaenoic Acid] results in increased expression of HMOX1 mRNA; astaxanthine inhibits the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]
CTD PMID:20038455 PMID:23272707 PMID:24157545 PMID:33008094 PMID:33212048 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
JBrowse link
G HOXA9 homeobox A9 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of HOXA9 mRNA] CTD PMID:16964424 NCBI chr 7:27,162,438...27,165,537
Ensembl chr 7:27,162,438...27,175,180
JBrowse link
G IDH1 isocitrate dehydrogenase (NADP(+)) 1 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of IDH1 mRNA] CTD PMID:16964424 NCBI chr 2:208,236,227...208,255,071
Ensembl chr 2:208,236,229...208,266,074
JBrowse link
G IFNG interferon gamma increases expression ISO astaxanthine results in increased expression of IFNG protein CTD PMID:33132140 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IL10 interleukin 10 multiple interactions ISO astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of IL10 mRNA]
astaxanthine inhibits the reaction [thiacloprid results in increased expression of IL10 protein]
CTD PMID:33008094 PMID:34564187 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL11 interleukin 11 increases expression ISO astaxanthine results in increased expression of IL11 protein CTD PMID:33132140 NCBI chr19:55,364,382...55,370,463
Ensembl chr19:55,364,382...55,370,463
JBrowse link
G IL1B interleukin 1 beta decreases expression
multiple interactions
ISO astaxanthine results in decreased expression of IL1B mRNA; astaxanthine results in decreased expression of IL1B protein
astaxanthine inhibits the reaction [IL1B protein results in decreased expression of COL2A1 protein]; astaxanthine inhibits the reaction [IL1B protein results in decreased expression of GPX4 protein]; astaxanthine inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; astaxanthine inhibits the reaction [IL1B protein results in increased expression of NOS2 protein]; astaxanthine inhibits the reaction [IL1B protein results in increased expression of P53 protein]; astaxanthine inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; astaxanthine inhibits the reaction [thiacloprid results in increased expression of IL1B protein]
astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of IL1B mRNA]
CTD PMID:21621527 PMID:33008094 PMID:34564187 PMID:36084724 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL6 interleukin 6 decreases expression
multiple interactions
ISO astaxanthine results in decreased expression of IL6 mRNA
astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of IL6 mRNA]
CTD PMID:21621527 PMID:33008094 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G INS-IGF2 INS-IGF2 readthrough decreases expression ISO astaxanthine results in decreased expression of INS1 protein CTD PMID:33132140 NCBI chr11:2,129,117...2,161,209
Ensembl chr11:2,132,538...2,161,209
JBrowse link
G LEPR leptin receptor multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of AIFM1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of APP mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of CAT mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of CNTD1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX15 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX5A mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX5B mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX6B1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX6C mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of FOXO3 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GNA13 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GPX3 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GRN mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of HMGB1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of HOXA9 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of IDH1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of ND6 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFA1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFA5 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFC2 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFV2 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NME2 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of PPP1CB mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of PRDX1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of RPS2 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of SOD1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of SPP1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of TGM2 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of TKT mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UBB mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UQCRB mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UQCRC2 mRNA] CTD PMID:16964424 NCBI chr 1:65,420,652...65,641,559
Ensembl chr 1:65,420,652...65,641,559
JBrowse link
G MAP1LC3B2 microtubule associated protein 1 light chain 3 beta 2 multiple interactions EXP astaxanthine inhibits the reaction [bisphenol A results in increased expression of MAP1LC3B2 mRNA] CTD PMID:34439521 NCBI chr12:116,559,381...116,576,606
Ensembl chr12:116,548,105...116,576,606
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP astaxanthine inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein] CTD PMID:34439521 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP astaxanthine inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK3 protein] CTD PMID:34439521 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions ISO astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased phosphorylation of MAPK8 protein] CTD PMID:33008094 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360
JBrowse link
G MMP13 matrix metallopeptidase 13 multiple interactions ISO astaxanthine inhibits the reaction [IL1B protein results in increased expression of MMP13 protein] CTD PMID:36084724 NCBI chr11:102,942,995...102,955,732
Ensembl chr11:102,942,995...102,955,732
JBrowse link
G MT-ND6 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of ND6 mRNA] CTD PMID:16964424 NCBI chr MT:14,149...14,673
Ensembl chr MT:14,149...14,673
JBrowse link
G NDUFA1 NADH:ubiquinone oxidoreductase subunit A1 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFA1 mRNA] CTD PMID:16964424 NCBI chr  X:119,871,832...119,876,662
Ensembl chr  X:119,871,832...119,876,662
JBrowse link
G NDUFA5 NADH:ubiquinone oxidoreductase subunit A5 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFA5 mRNA] CTD PMID:16964424 NCBI chr 7:123,536,997...123,601,651
Ensembl chr 7:123,536,997...123,557,904
JBrowse link
G NDUFC2 NADH:ubiquinone oxidoreductase subunit C2 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFC2 mRNA] CTD PMID:16964424 NCBI chr11:78,068,297...78,079,862
Ensembl chr11:78,068,297...78,079,862
JBrowse link
G NDUFV2 NADH:ubiquinone oxidoreductase core subunit V2 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFV2 mRNA] CTD PMID:16964424 NCBI chr18:9,102,699...9,134,341
Ensembl chr18:9,102,630...9,134,345
JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 increases expression
multiple interactions
ISO
EXP
astaxanthine results in increased expression of NFE2L2 protein
astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which affects the localization of NFE2L2 protein]
[astaxanthine co-treated with Cyclophosphamide] results in increased expression of NFE2L2 protein; astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NFE2L2 protein]; tin protoporphyrin IX inhibits the reaction [astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NFE2L2 protein]]
astaxanthine results in increased expression of NFE2L2 mRNA
[astaxanthine co-treated with Docosahexaenoic Acids] results in increased expression of NFE2L2 mRNA; [astaxanthine co-treated with Eicosapentaenoic Acid] results in increased expression of NFE2L2 mRNA; astaxanthine promotes the reaction [Hydrogen Peroxide results in increased expression of NFE2L2 mRNA]
CTD PMID:20038455 PMID:23272707 PMID:24157545 PMID:33008094 PMID:33212048 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756
JBrowse link
G NME2 NME/NM23 nucleoside diphosphate kinase 2 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NME2 mRNA] CTD PMID:16964424 NCBI chr17:51,165,536...51,171,744
Ensembl chr17:51,165,435...51,171,744
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of NOS2 mRNA]; astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of NOS2 protein]
astaxanthine inhibits the reaction [IL1B protein results in increased expression of NOS2 protein]; astaxanthine inhibits the reaction [thiacloprid results in increased expression of NOS2 mRNA]
CTD PMID:33008094 PMID:34564187 PMID:36084724 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
ISO
EXP
[astaxanthine co-treated with Cyclophosphamide] results in increased expression of NQO1 protein
[astaxanthine co-treated with Docosahexaenoic Acids] results in increased expression of NQO1 mRNA; [astaxanthine co-treated with Eicosapentaenoic Acid] results in increased expression of NQO1 mRNA; astaxanthine inhibits the reaction [Hydrogen Peroxide results in increased expression of NQO1 mRNA]
astaxanthine results in increased expression of NQO1 mRNA
astaxanthine results in increased expression of NQO1 protein
CTD PMID:20038455 PMID:24157545 PMID:33212048 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G PAH phenylalanine hydroxylase decreases expression ISO astaxanthine results in decreased expression of PAH mRNA CTD PMID:19555370 NCBI chr12:102,836,889...102,958,441
Ensembl chr12:102,836,889...102,958,410
JBrowse link
G PGD phosphogluconate dehydrogenase increases activity ISO astaxanthine results in increased activity of PGD protein CTD PMID:28665548 PMID:29975440 NCBI chr 1:10,399,064...10,420,511
Ensembl chr 1:10,398,592...10,420,511
JBrowse link
G POR cytochrome p450 oxidoreductase decreases activity
increases expression
ISO astaxanthine results in decreased activity of POR protein
astaxanthine results in increased expression of POR protein
CTD PMID:21414371 NCBI chr 7:75,915,155...75,986,855
Ensembl chr 7:75,899,200...75,986,855
JBrowse link
G PPP1CB protein phosphatase 1 catalytic subunit beta multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of PPP1CB mRNA] CTD PMID:16964424 NCBI chr 2:28,751,604...28,802,940
Ensembl chr 2:28,751,640...28,802,940
JBrowse link
G PRDX1 peroxiredoxin 1 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of PRDX1 mRNA] CTD PMID:16964424 NCBI chr 1:45,511,051...45,522,890
Ensembl chr 1:45,510,914...45,542,732
JBrowse link
G PTEN phosphatase and tensin homolog multiple interactions EXP astaxanthine inhibits the reaction [Hydrogen Peroxide results in increased expression of PTEN mRNA] CTD PMID:33212048 NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,862,638...87,971,930
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions
ISO astaxanthine results in decreased expression of PTGS2 mRNA
astaxanthine inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]
astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of PTGS2 mRNA]
CTD PMID:21621527 PMID:33008094 PMID:36084724 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP astaxanthine inhibits the reaction [bisphenol A results in increased phosphorylation of RELA protein] CTD PMID:34439521 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090
JBrowse link
G RPS2 ribosomal protein S2 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of RPS2 mRNA] CTD PMID:16964424 NCBI chr16:1,962,058...1,964,826
Ensembl chr16:1,962,058...1,964,841
JBrowse link
G SKAP2 src kinase associated phosphoprotein 2 decreases expression ISO astaxanthine results in decreased expression of SKAP2 mRNA CTD PMID:19555370 NCBI chr 7:26,654,770...26,864,590
Ensembl chr 7:26,667,068...26,995,239
JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of SOD1 mRNA] CTD PMID:16964424 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931
JBrowse link
G SP1 Sp1 transcription factor multiple interactions ISO [mithramycin A co-treated with astaxanthine] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of and affects the localization of SP1 protein]; astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 mRNA]; astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 protein]; astaxanthine promotes the reaction [mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 mRNA]]; astaxanthine promotes the reaction [mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 protein]]; mithramycin A promotes the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 mRNA]]; mithramycin A promotes the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 protein]] CTD PMID:23538867 NCBI chr12:53,380,176...53,416,446
Ensembl chr12:53,380,176...53,416,446
JBrowse link
G SPP1 secreted phosphoprotein 1 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of SPP1 mRNA] CTD PMID:16964424 NCBI chr 4:87,975,714...87,983,411
Ensembl chr 4:87,975,667...87,983,532
JBrowse link
G TGM2 transglutaminase 2 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of TGM2 mRNA] CTD PMID:16964424 NCBI chr20:38,127,385...38,168,475
Ensembl chr20:38,127,385...38,166,578
JBrowse link
G TKT transketolase multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of TKT mRNA] CTD PMID:16964424 NCBI chr 3:53,224,712...53,256,022
Ensembl chr 3:53,224,712...53,256,052
JBrowse link
G TLR2 toll like receptor 2 multiple interactions ISO astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of TLR2 mRNA] CTD PMID:33008094 NCBI chr 4:153,684,280...153,710,637
Ensembl chr 4:153,684,050...153,706,260
JBrowse link
G TLR4 toll like receptor 4 multiple interactions ISO astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of TLR4 mRNA] CTD PMID:33008094 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735
JBrowse link
G TNF tumor necrosis factor decreases expression
multiple interactions
increases expression
ISO astaxanthine results in decreased expression of TNF protein
astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of TNF mRNA]
astaxanthine results in increased expression of TNF protein
CTD PMID:21621527 PMID:33008094 PMID:33132140 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TP53 tumor protein p53 multiple interactions ISO astaxanthine inhibits the reaction [Cyclophosphamide results in increased expression of TP53 protein] CTD PMID:20038455 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546
JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 multiple interactions ISO astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of TREM2 mRNA] CTD PMID:33008094 NCBI chr 6:41,158,508...41,163,116
Ensembl chr 6:41,158,506...41,163,186
JBrowse link
G UBB ubiquitin B multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UBB mRNA] CTD PMID:16964424 NCBI chr17:16,380,779...16,382,745
Ensembl chr17:16,380,798...16,382,745
JBrowse link
G UQCRB ubiquinol-cytochrome c reductase binding protein multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UQCRB mRNA] CTD PMID:16964424 NCBI chr 8:96,222,947...96,235,545
Ensembl chr 8:96,222,947...96,235,546
JBrowse link
G UQCRC2 ubiquinol-cytochrome c reductase core protein 2 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UQCRC2 mRNA] CTD PMID:16964424 NCBI chr16:21,953,361...21,983,660
Ensembl chr16:21,953,288...21,983,660
JBrowse link
beta-carotene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACAD9 acyl-CoA dehydrogenase family member 9 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ACAD9 mRNA CTD PMID:24657404 NCBI chr 3:128,879,620...128,913,114
Ensembl chr 3:128,879,596...128,924,003
JBrowse link
G ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide increases expression EXP beta Carotene results in increased expression of ADH1A mRNA CTD PMID:17034753 NCBI chr 4:99,276,369...99,290,985
Ensembl chr 4:99,276,369...99,291,003
JBrowse link
G ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide increases expression EXP beta Carotene results in increased expression of ADH5 mRNA CTD PMID:17034753 NCBI chr 4:99,070,978...99,088,788
Ensembl chr 4:99,070,978...99,088,801
JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing decreases expression ISO beta Carotene results in decreased expression of ADIPOQ mRNA CTD PMID:21569430 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463
JBrowse link
G AEBP1 AE binding protein 1 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of AEBP1 mRNA CTD PMID:24657404 NCBI chr 7:44,104,345...44,114,560
Ensembl chr 7:44,104,345...44,114,562
JBrowse link
G AKT1 AKT serine/threonine kinase 1 decreases phosphorylation
decreases expression
EXP
ISO
beta Carotene results in decreased phosphorylation of AKT1 protein
beta Carotene results in decreased expression of AKT1 mRNA
CTD PMID:26733226 PMID:36819991 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759
JBrowse link
G ALAD aminolevulinate dehydratase multiple interactions ISO beta Carotene inhibits the reaction [arsenic trioxide results in decreased expression of ALAD protein] CTD PMID:25542264 NCBI chr 9:113,386,312...113,401,284
Ensembl chr 9:113,386,312...113,401,290
JBrowse link
G ALDH3B1 aldehyde dehydrogenase 3 family member B1 decreases expression EXP beta Carotene results in decreased expression of ALDH3B1 mRNA CTD PMID:17034753 NCBI chr11:68,008,547...68,029,276
Ensembl chr11:68,008,578...68,029,282
JBrowse link
G ALDH4A1 aldehyde dehydrogenase 4 family member A1 decreases expression EXP beta Carotene results in decreased expression of ALDH4A1 mRNA CTD PMID:17034753 NCBI chr 1:18,871,430...18,902,555
Ensembl chr 1:18,871,430...18,902,724
JBrowse link
G ANK2 ankyrin 2 increases expression EXP beta Carotene results in increased expression of ANK2 mRNA CTD PMID:17034753 NCBI chr 4:112,705,622...113,383,736
Ensembl chr 4:112,818,032...113,384,221
JBrowse link
G ANK3 ankyrin 3 increases expression EXP beta Carotene results in increased expression of ANK3 mRNA CTD PMID:17034753 NCBI chr10:60,026,298...60,733,528
Ensembl chr10:60,026,298...60,733,490
JBrowse link
G APPBP2 amyloid beta precursor protein binding protein 2 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of APPBP2 mRNA CTD PMID:24657404 NCBI chr17:60,443,158...60,526,242
Ensembl chr17:60,443,158...60,526,242
JBrowse link
G ARHGAP26 Rho GTPase activating protein 26 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ARHGAP26 mRNA CTD PMID:24657404 NCBI chr 5:142,770,377...143,229,011
Ensembl chr 5:142,770,377...143,229,011
JBrowse link
G ASAH1 N-acylsphingosine amidohydrolase 1 increases expression EXP beta Carotene results in increased expression of ASAH1 mRNA CTD PMID:17034753 NCBI chr 8:18,055,992...18,084,961
Ensembl chr 8:18,055,992...18,084,998
JBrowse link
G ASB1 ankyrin repeat and SOCS box containing 1 increases expression EXP beta Carotene results in increased expression of ASB1 mRNA CTD PMID:17034753 NCBI chr 2:238,426,927...238,452,250
Ensembl chr 2:238,426,742...238,452,250
JBrowse link
G ASB9 ankyrin repeat and SOCS box containing 9 increases expression EXP beta Carotene results in increased expression of ASB9 mRNA CTD PMID:17034753 NCBI chr  X:15,243,987...15,270,467
Ensembl chr  X:15,235,288...15,270,467
JBrowse link
G ATP8B1 ATPase phospholipid transporting 8B1 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ATP8B1 mRNA CTD PMID:24657404 NCBI chr18:57,646,426...57,803,315
Ensembl chr18:57,646,426...57,803,315
JBrowse link
G BAG3 BAG cochaperone 3 decreases expression EXP beta Carotene results in decreased expression of BAG3 mRNA CTD PMID:17034753 NCBI chr10:119,651,380...119,677,819
Ensembl chr10:119,651,380...119,677,819
JBrowse link
G BAG4 BAG cochaperone 4 decreases expression EXP beta Carotene results in decreased expression of BAG4 mRNA CTD PMID:17034753 NCBI chr 8:38,176,855...38,213,301
Ensembl chr 8:38,176,533...38,213,301
JBrowse link
G BAG5 BAG cochaperone 5 decreases expression EXP beta Carotene results in decreased expression of BAG5 mRNA CTD PMID:17034753 NCBI chr14:103,556,551...103,562,657
Ensembl chr14:103,556,545...103,562,657
JBrowse link
G BAX BCL2 associated X, apoptosis regulator decreases expression
increases expression
EXP beta Carotene results in decreased expression of BAX mRNA
beta Carotene results in increased expression of BAX mRNA; beta Carotene results in increased expression of BAX protein
CTD PMID:15949688 PMID:17034753 PMID:26733226 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression EXP beta Carotene results in decreased expression of BCL2 protein CTD PMID:26733226 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCO1 beta-carotene oxygenase 1 multiple interactions
affects response to substance
increases oxidation
increases expression
EXP
ISO
beta Carotene results in increased expression of and results in increased activity of BCO1 protein
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ACAD9 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of AEBP1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of APPBP2 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ARHGAP26 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ATP8B1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CDCA8 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CENPE mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CLCN3 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of COQ7 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CTNNAL1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of DHFR mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of DTWD2 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of EDN1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of EIF2S1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of FOXM1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of FZD6 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of IRX4 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ITM2A mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of KIF11 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of LANCL1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of LMNB2 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of METTL21A mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of METTL9 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of MRPL57 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of MTCH2 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of NCKAP1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of NOM1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PARD6A mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PCDH1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PLAT mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of RPP14 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of RRM1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TFCP2 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of THOC7 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TMEM209 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TTC21B mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TWF1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TYMP mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of YTHDC2 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ZDHHC3 mRNA
BCO1 protein results in increased oxidation of beta Carotene
beta Carotene results in increased expression of BCO1 mRNA
Ascorbic Acid inhibits the reaction [Oxidants inhibits the reaction [BCO1 protein results in increased oxidation of beta Carotene]]; Oxidants inhibits the reaction [BCO1 protein results in increased oxidation of beta Carotene]; Vitamin E inhibits the reaction [Oxidants inhibits the reaction [BCO1 protein results in increased oxidation of beta Carotene]]
CTD PMID:9526112 PMID:16186334 PMID:24657404 NCBI chr16:81,238,689...81,291,142
Ensembl chr16:81,238,689...81,291,142
JBrowse link
G BCO2 beta-carotene oxygenase 2 multiple interactions
increases metabolic processing
ISO [BCO2 protein results in increased metabolism of beta Carotene] which results in increased chemical synthesis of apocarotenal CTD PMID:21106934 NCBI chr11:112,175,512...112,218,946
Ensembl chr11:112,175,510...112,224,699
JBrowse link
G CASP3 caspase 3 multiple interactions
increases activity
EXP alpha-Tocopherol promotes the reaction [beta Carotene metabolite results in decreased activity of CASP3 protein]
beta Carotene metabolite results in increased activity of CASP3 protein; beta Carotene results in increased activity of CASP3 protein
CTD PMID:17618090 PMID:26733226 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
JBrowse link
G CAT catalase multiple interactions ISO [Ascorbic Acid co-treated with beta Carotene co-treated with alpha-Tocopherol co-treated with Sodium Selenite] inhibits the reaction [Galactosamine results in increased activity of CAT protein]; beta Carotene inhibits the reaction [cholestane-3,5,6-triol results in decreased activity of CAT protein]; beta Carotene inhibits the reaction [Indomethacin results in decreased expression of CAT protein]
beta Carotene inhibits the reaction [arsenic trioxide results in decreased activity of CAT protein]
CTD PMID:9306888 PMID:12500499 PMID:25542264 PMID:31022331 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CAV1 caveolin 1 decreases expression EXP beta Carotene results in decreased expression of CAV1 protein CTD PMID:26733226 NCBI chr 7:116,525,009...116,561,185
Ensembl chr 7:116,524,994...116,561,179
JBrowse link
G CCND1 cyclin D1 decreases expression EXP beta Carotene results in decreased expression of CCND1 protein CTD PMID:26733226 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CDCA8 cell division cycle associated 8 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CDCA8 mRNA CTD PMID:24657404 NCBI chr 1:37,692,516...37,709,719
Ensembl chr 1:37,692,481...37,709,719
JBrowse link
G CDH1 cadherin 1 increases expression EXP beta Carotene results in increased expression of CDH1 mRNA; beta Carotene results in increased expression of CDH1 protein CTD PMID:17034753 PMID:26733226 NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,537
JBrowse link
G CEBPA CCAAT enhancer binding protein alpha decreases expression ISO beta Carotene results in decreased expression of CEBPA mRNA CTD PMID:21569430 NCBI chr19:33,299,934...33,302,534
Ensembl chr19:33,299,934...33,302,534
JBrowse link
G CENPE centromere protein E multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CENPE mRNA CTD PMID:24657404 NCBI chr 4:103,105,811...103,198,343
Ensembl chr 4:103,105,349...103,198,445
JBrowse link
G CFLAR CASP8 and FADD like apoptosis regulator increases expression EXP beta Carotene results in increased expression of CFLAR mRNA CTD PMID:17034753 NCBI chr 2:201,116,164...201,176,687
Ensembl chr 2:201,116,154...201,176,687
JBrowse link
G CLCN3 chloride voltage-gated channel 3 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CLCN3 mRNA CTD PMID:24657404 NCBI chr 4:169,620,578...169,723,673
Ensembl chr 4:169,612,633...169,723,673
JBrowse link
G CLDN10 claudin 10 increases expression EXP beta Carotene results in increased expression of CLDN10 mRNA CTD PMID:17034753 NCBI chr13:95,433,755...95,579,759
Ensembl chr13:95,433,604...95,579,759
JBrowse link
G CLDN18 claudin 18 increases expression EXP beta Carotene results in increased expression of CLDN18 mRNA CTD PMID:17034753 NCBI chr 3:137,998,816...138,033,649
Ensembl chr 3:137,998,735...138,033,655
JBrowse link
G COL1A1 collagen type I alpha 1 chain decreases expression EXP beta Carotene results in decreased expression of COL1A1 mRNA CTD PMID:17034753 NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632
JBrowse link
G COL4A1 collagen type IV alpha 1 chain decreases expression EXP beta Carotene results in decreased expression of COL4A1 mRNA CTD PMID:17034753 NCBI chr13:110,148,963...110,307,157
Ensembl chr13:110,148,963...110,307,202
JBrowse link
G COL4A2 collagen type IV alpha 2 chain decreases expression EXP beta Carotene results in decreased expression of COL4A2 mRNA CTD PMID:17034753 NCBI chr13:110,307,284...110,513,209
Ensembl chr13:110,305,812...110,513,209
JBrowse link
G COQ7 coenzyme Q7, hydroxylase multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of COQ7 mRNA CTD PMID:24657404 NCBI chr16:19,067,614...19,083,097
Ensembl chr16:19,067,614...19,080,095
JBrowse link
G CPT1B carnitine palmitoyltransferase 1B decreases expression ISO beta Carotene results in decreased expression of CPT1B mRNA CTD PMID:21569430 NCBI chr22:50,568,861...50,578,612
Ensembl chr22:50,568,861...50,578,465
JBrowse link
G CRADD CASP2 and RIPK1 domain containing adaptor with death domain increases expression EXP beta Carotene results in increased expression of CRADD mRNA CTD PMID:17034753 NCBI chr12:93,677,375...93,894,840
Ensembl chr12:93,677,375...93,894,840
JBrowse link
G CTNNAL1 catenin alpha like 1 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CTNNAL1 mRNA CTD PMID:24657404 NCBI chr 9:108,942,577...109,013,499
Ensembl chr 9:108,942,569...109,013,522
JBrowse link
G CTSB cathepsin B decreases expression EXP beta Carotene results in decreased expression of CTSB mRNA CTD PMID:17034753 NCBI chr 8:11,842,524...11,868,087
Ensembl chr 8:11,842,524...11,869,533
JBrowse link
G CXCL12 C-X-C motif chemokine ligand 12 increases expression EXP beta Carotene results in increased expression of CXCL12 mRNA CTD PMID:17034753 NCBI chr10:44,370,165...44,385,097
Ensembl chr10:44,370,165...44,386,493
JBrowse link
G CXCL6 C-X-C motif chemokine ligand 6 increases expression EXP beta Carotene results in increased expression of CXCL6 mRNA CTD PMID:17034753 NCBI chr 4:73,836,678...73,838,760
Ensembl chr 4:73,836,640...73,849,064
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP beta Carotene promotes the reaction [Tetradecanoylphorbol Acetate results in increased secretion of CXCL8 protein] CTD PMID:19135038 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716
JBrowse link
G CXCL9 C-X-C motif chemokine ligand 9 increases expression EXP beta Carotene results in increased expression of CXCL9 mRNA CTD PMID:17034753 NCBI chr 4:76,001,275...76,007,509
Ensembl chr 4:76,001,275...76,007,509
JBrowse link
G CXCR4 C-X-C motif chemokine receptor 4 increases expression EXP beta Carotene results in increased expression of CXCR4 mRNA CTD PMID:17034753 NCBI chr 2:136,114,349...136,118,149
Ensembl chr 2:136,114,349...136,119,177
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 multiple interactions EXP beta Carotene promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein]; Quercetin inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein]] CTD PMID:16970932 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP26A1 cytochrome P450 family 26 subfamily A member 1 increases expression EXP beta Carotene results in increased expression of CYP26A1 mRNA CTD PMID:16186334 PMID:22542753 NCBI chr10:93,073,475...93,077,885
Ensembl chr10:93,073,475...93,077,885
JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 increases expression EXP beta Carotene results in increased expression of CYP2C9 mRNA CTD PMID:17034753 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 multiple interactions EXP beta Carotene promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] CTD PMID:16632523 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G CYP3A43 cytochrome P450 family 3 subfamily A member 43 increases expression EXP beta Carotene results in increased expression of CYP3A43 mRNA CTD PMID:17034753 NCBI chr 7:99,828,013...99,866,093
Ensembl chr 7:99,828,013...99,866,093
JBrowse link
G DHFR dihydrofolate reductase multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of DHFR mRNA CTD PMID:24657404 NCBI chr 5:80,626,226...80,654,983
Ensembl chr 5:80,626,226...80,654,983
JBrowse link
G DLX2 distal-less homeobox 2 increases expression EXP beta Carotene results in increased expression of DLX2 mRNA CTD PMID:17034753 NCBI chr 2:172,099,438...172,102,900
Ensembl chr 2:172,099,438...172,102,900
JBrowse link
G DLX4 distal-less homeobox 4 increases expression EXP beta Carotene results in increased expression of DLX4 mRNA CTD PMID:17034753 NCBI chr17:49,968,572...49,974,959
Ensembl chr17:49,968,588...49,974,959
JBrowse link
G DPP4 dipeptidyl peptidase 4 multiple interactions ISO [Xiao-Ke-An results in increased abundance of beta Carotene] which results in decreased activity of DPP4 protein CTD PMID:32535096 NCBI chr 2:161,992,245...162,074,215
Ensembl chr 2:161,992,245...162,074,394
JBrowse link
G DTWD2 DTW domain containing 2 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of DTWD2 mRNA CTD PMID:24657404 NCBI chr 5:118,836,074...118,988,547
Ensembl chr 5:118,836,074...118,988,547
JBrowse link
G EDN1 endothelin 1 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of EDN1 mRNA CTD PMID:24657404 NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194
JBrowse link
G EIF2S1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of EIF2S1 mRNA CTD PMID:24657404 NCBI chr14:67,360,328...67,386,516
Ensembl chr14:67,360,328...67,386,516
JBrowse link
G ERCC2 ERCC excision repair 2, TFIIH core complex helicase subunit decreases expression EXP beta Carotene results in decreased expression of ERCC2 mRNA CTD PMID:17034753 NCBI chr19:45,349,837...45,370,573
Ensembl chr19:45,349,837...45,370,918
JBrowse link
G ESR1 estrogen receptor 1 multiple interactions EXP beta Carotene inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; beta Carotene inhibits the reaction [Genistein results in increased activity of ESR1 protein]; beta Carotene inhibits the reaction [Paclitaxel results in increased expression of ESR1 mRNA] CTD PMID:17051425 PMID:19340624 NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619
JBrowse link
G ESR2 estrogen receptor 2 multiple interactions EXP beta Carotene inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; beta Carotene inhibits the reaction [Genistein results in increased activity of ESR2 protein] CTD PMID:17051425 NCBI chr14:64,226,707...64,338,613
Ensembl chr14:64,084,232...64,338,112
JBrowse link
G FABP4 fatty acid binding protein 4 decreases expression ISO beta Carotene results in decreased expression of FABP4 mRNA CTD PMID:21569430 NCBI chr 8:81,478,419...81,483,233
Ensembl chr 8:81,478,419...81,483,236
JBrowse link
G FAIM2 Fas apoptotic inhibitory molecule 2 increases expression EXP beta Carotene results in increased expression of FAIM2 mRNA CTD PMID:17034753 NCBI chr12:49,866,896...49,903,900
Ensembl chr12:49,866,896...49,904,217
JBrowse link
G FAS Fas cell surface death receptor increases expression EXP beta Carotene results in increased expression of FAS mRNA CTD PMID:17034753 NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605
JBrowse link
G FOSL1 FOS like 1, AP-1 transcription factor subunit increases expression ISO beta Carotene results in increased expression of FOSL1 protein CTD PMID:20025956 NCBI chr11:65,892,049...65,900,545
Ensembl chr11:65,892,049...65,900,573
JBrowse link
G FOXA1 forkhead box A1 increases expression EXP beta Carotene results in increased expression of FOXA1 mRNA CTD PMID:17034753 NCBI chr14:37,589,552...37,595,249
Ensembl chr14:37,589,552...37,596,059
JBrowse link
G FOXM1 forkhead box M1 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of FOXM1 mRNA CTD PMID:24657404 NCBI chr12:2,857,680...2,877,174
Ensembl chr12:2,857,680...2,877,174
JBrowse link
G FZD6 frizzled class receptor 6 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of FZD6 mRNA CTD PMID:24657404 NCBI chr 8:103,298,494...103,332,866
Ensembl chr 8:103,298,433...103,332,866
JBrowse link
G GATA6 GATA binding protein 6 increases expression EXP beta Carotene results in increased expression of GATA6 mRNA CTD PMID:17034753 NCBI chr18:22,169,589...22,202,528
Ensembl chr18:22,169,589...22,202,528
JBrowse link
G GBP1 guanylate binding protein 1 increases expression EXP beta Carotene results in increased expression of GBP1 mRNA CTD PMID:17034753 NCBI chr 1:89,052,319...89,065,208
Ensembl chr 1:89,051,882...89,065,360
JBrowse link
G GJA1 gap junction protein alpha 1 multiple interactions
increases expression
ISO beta Carotene promotes the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of GJA1 protein]; Ro 41-5253 inhibits the reaction [beta Carotene results in increased expression of GJA1 protein]
beta Carotene inhibits the reaction [Hydrogen Peroxide results in decreased expression of GJA1 mRNA]; beta Carotene inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of GJA1 protein]
CTD PMID:16091010 PMID:27154496 NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727
JBrowse link
G GJA9 gap junction protein alpha 9 increases expression EXP beta Carotene results in increased expression of GJA9 mRNA CTD PMID:17034753 NCBI chr 1:38,874,069...38,881,587
Ensembl chr 1:38,874,069...38,881,587
JBrowse link
G GSR glutathione-disulfide reductase multiple interactions ISO beta Carotene inhibits the reaction [arsenic trioxide results in decreased activity of GSR protein] CTD PMID:25542264 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G GSTK1 glutathione S-transferase kappa 1 decreases expression EXP beta Carotene results in decreased expression of GSTK1 mRNA CTD PMID:17034753 NCBI chr 7:143,263,441...143,269,115
Ensembl chr 7:143,244,093...143,270,854
JBrowse link
G GSTM2 glutathione S-transferase mu 2 increases expression EXP beta Carotene results in increased expression of GSTM2 mRNA CTD PMID:17034753 NCBI chr 1:109,668,057...109,683,997
Ensembl chr 1:109,668,022...109,709,551
JBrowse link
G GSTM4 glutathione S-transferase mu 4 decreases expression EXP beta Carotene results in decreased expression of GSTM4 mRNA CTD PMID:17034753 NCBI chr 1:109,656,099...109,667,727
Ensembl chr 1:109,656,099...109,665,496
JBrowse link
G GSTM5 glutathione S-transferase mu 5 increases expression EXP beta Carotene results in increased expression of GSTM5 mRNA CTD PMID:17034753 NCBI chr 1:109,711,751...109,718,268
Ensembl chr 1:109,711,780...109,775,428
JBrowse link
G GSTZ1 glutathione S-transferase zeta 1 decreases expression EXP beta Carotene results in decreased expression of GSTZ1 mRNA CTD PMID:17034753 NCBI chr14:77,321,036...77,331,597
Ensembl chr14:77,320,996...77,331,597
JBrowse link
G HOXA7 homeobox A7 increases expression EXP beta Carotene results in increased expression of HOXA7 mRNA CTD PMID:17034753 NCBI chr 7:27,153,716...27,156,675
Ensembl chr 7:27,153,716...27,157,936
JBrowse link
G HOXB6 homeobox B6 increases expression EXP beta Carotene results in increased expression of HOXB6 mRNA CTD PMID:17034753 NCBI chr17:48,595,751...48,604,986
Ensembl chr17:48,595,751...48,604,992
JBrowse link
G HOXC10 homeobox C10 increases expression EXP beta Carotene results in increased expression of HOXC10 mRNA CTD PMID:17034753 NCBI chr12:53,985,146...53,990,279
Ensembl chr12:53,985,065...53,990,279
JBrowse link
G HPRT1 hypoxanthine phosphoribosyltransferase 1 multiple interactions ISO beta Carotene inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of HPRT1 gene] CTD PMID:12467141 NCBI chr  X:134,460,165...134,500,668
Ensembl chr  X:134,460,165...134,520,513
JBrowse link
G IFNA14 interferon alpha 14 increases expression EXP beta Carotene results in increased expression of IFNA14 mRNA CTD PMID:17034753 NCBI chr 9:21,239,002...21,240,005
Ensembl chr 9:21,239,002...21,240,005
JBrowse link
G IFNA16 interferon alpha 16 increases expression EXP beta Carotene results in increased expression of IFNA16 mRNA CTD PMID:17034753 NCBI chr 9:21,216,373...21,217,311
Ensembl chr 9:21,216,373...21,217,311
JBrowse link
G IFNA17 interferon alpha 17 increases expression EXP beta Carotene results in increased expression of IFNA17 mRNA CTD PMID:17034753 NCBI chr 9:21,227,243...21,228,222
Ensembl chr 9:21,227,243...21,228,222
JBrowse link
G IFNA5 interferon alpha 5 increases expression EXP beta Carotene results in increased expression of IFNA5 mRNA CTD PMID:17034753 NCBI chr 9:21,304,326...21,305,313
Ensembl chr 9:21,304,326...21,305,313
JBrowse link
G IGFBP5 insulin like growth factor binding protein 5 multiple interactions ISO [alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of IGFBP5 mRNA CTD PMID:23859036 NCBI chr 2:216,672,105...216,695,549
Ensembl chr 2:216,672,105...216,695,549
JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of IL1B protein]; pyrazolanthrone inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of IL1B protein]]; Quercetin inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of IL1B protein]] CTD PMID:21447443 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IRF8 interferon regulatory factor 8 increases expression EXP beta Carotene results in increased expression of IRF8 mRNA CTD PMID:17034753 NCBI chr16:85,899,162...85,922,609
Ensembl chr16:85,899,116...85,922,606
JBrowse link
G IRX4 iroquois homeobox 4 decreases expression
multiple interactions
EXP
ISO
beta Carotene results in decreased expression of IRX4 mRNA
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of IRX4 mRNA
CTD PMID:17034753 PMID:24657404 NCBI chr 5:1,877,413...1,887,179
Ensembl chr 5:1,877,413...1,887,236
JBrowse link
G ITGB1 integrin subunit beta 1 decreases expression EXP beta Carotene results in decreased expression of ITGB1 mRNA CTD PMID:17034753 NCBI chr10:32,900,318...32,958,230
Ensembl chr10:32,887,273...33,005,792
JBrowse link
G ITGB4 integrin subunit beta 4 decreases expression EXP beta Carotene results in decreased expression of ITGB4 mRNA CTD PMID:17034753 NCBI chr17:75,721,459...75,757,818
Ensembl chr17:75,721,328...75,757,818
JBrowse link
G ITM2A integral membrane protein 2A multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ITM2A mRNA CTD PMID:24657404 NCBI chr  X:79,360,384...79,367,334
Ensembl chr  X:79,360,384...79,367,667
JBrowse link
G IVL involucrin increases expression EXP beta Carotene results in increased expression of IVL mRNA CTD PMID:17034753 NCBI chr 1:152,908,546...152,911,886
Ensembl chr 1:152,908,546...152,911,886
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO beta Carotene results in increased expression of JUN protein CTD PMID:20025956 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048
JBrowse link
G KIF11 kinesin family member 11 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of KIF11 mRNA CTD PMID:24657404 NCBI chr10:92,593,130...92,655,395
Ensembl chr10:92,574,105...92,655,395
JBrowse link
G KRT18 keratin 18 increases expression EXP beta Carotene results in increased expression of KRT18 mRNA CTD PMID:17034753 NCBI chr12:52,948,855...52,952,906
Ensembl chr12:52,948,871...52,952,906
JBrowse link
G KRT19 keratin 19 increases expression EXP beta Carotene results in increased expression of KRT19 mRNA CTD PMID:17034753 NCBI chr17:41,523,617...41,528,308
Ensembl chr17:41,523,617...41,528,308
JBrowse link
G KRT2 keratin 2 increases expression EXP beta Carotene results in increased expression of KRT2 mRNA CTD PMID:17034753 NCBI chr12:52,644,558...52,652,211
Ensembl chr12:52,644,558...52,652,211
JBrowse link
G KRT7 keratin 7 affects expression EXP beta Carotene affects the expression of KRT7 mRNA CTD PMID:17034753 NCBI chr12:52,233,243...52,255,853
Ensembl chr12:52,232,520...52,252,186
JBrowse link
G KRT8 keratin 8 decreases expression EXP beta Carotene results in decreased expression of KRT8 mRNA CTD PMID:17034753 NCBI chr12:52,897,191...52,949,860
Ensembl chr12:52,897,187...52,949,954
JBrowse link
G LANCL1 LanC like glutathione S-transferase 1 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of LANCL1 mRNA CTD PMID:24657404 NCBI chr 2:210,431,251...210,477,584
Ensembl chr 2:210,427,131...210,477,652
JBrowse link
G LHX3 LIM homeobox 3 increases expression EXP beta Carotene results in increased expression of LHX3 mRNA CTD PMID:17034753 NCBI chr 9:136,196,250...136,205,128
Ensembl chr 9:136,196,250...136,205,128
JBrowse link
G LMNB2 lamin B2 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of LMNB2 mRNA CTD PMID:24657404 NCBI chr19:2,428,166...2,456,959
Ensembl chr19:2,427,638...2,456,959
JBrowse link
G LPL lipoprotein lipase decreases expression ISO beta Carotene results in decreased expression of LPL mRNA CTD PMID:21569430 NCBI chr 8:19,939,253...19,967,259
Ensembl chr 8:19,901,717...19,967,259
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation
multiple interactions
EXP
ISO
beta Carotene results in increased phosphorylation of MAPK1 protein
beta Carotene inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]
CTD PMID:16206275 PMID:27154496 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation
multiple interactions
EXP
ISO
beta Carotene results in increased phosphorylation of MAPK3 protein
beta Carotene inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]
CTD PMID:16206275 PMID:27154496 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MBL2 mannose binding lectin 2 multiple interactions EXP MBL2 gene polymorphism affects the susceptibility to [Vitamin A co-treated with beta Carotene] CTD PMID:16960176 NCBI chr10:52,765,380...52,772,784
Ensembl chr10:52,765,380...52,772,784
JBrowse link
G MCL1 MCL1 apoptosis regulator, BCL2 family member affects expression EXP beta Carotene affects the expression of MCL1 mRNA CTD PMID:17034753 NCBI chr 1:150,574,558...150,579,610
Ensembl chr 1:150,560,895...150,579,738
JBrowse link
G MEIS2 Meis homeobox 2 increases expression EXP beta Carotene results in increased expression of MEIS2 mRNA CTD PMID:17034753 NCBI chr15:36,889,204...37,101,311
Ensembl chr15:36,889,204...37,101,299
JBrowse link
G MEOX1 mesenchyme homeobox 1 increases expression EXP beta Carotene results in increased expression of MEOX1 mRNA CTD PMID:17034753 NCBI chr17:43,640,389...43,661,922
Ensembl chr17:43,640,389...43,661,922
JBrowse link
G METTL21A methyltransferase 21A, HSPA lysine multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of METTL21A mRNA CTD PMID:24657404 NCBI chr 2:207,580,635...207,626,053
Ensembl chr 2:207,580,631...207,625,928
JBrowse link
G METTL9 methyltransferase 9, His-X-His N1(pi)-histidine multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of METTL9 mRNA CTD PMID:24657404 NCBI chr16:21,597,208...21,657,471
Ensembl chr16:21,597,218...21,657,471
JBrowse link
G MGMT O-6-methylguanine-DNA methyltransferase affects response to substance EXP MGMT gene SNP affects the susceptibility to beta Carotene CTD PMID:16014702 NCBI chr10:129,467,241...129,770,983
Ensembl chr10:129,467,190...129,770,983
JBrowse link
G MKI67 marker of proliferation Ki-67 multiple interactions ISO [alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of MKI67 mRNA CTD PMID:23859036 NCBI chr10:128,096,659...128,126,423
Ensembl chr10:128,096,659...128,126,423
JBrowse link
G MNX1 motor neuron and pancreas homeobox 1 increases expression EXP beta Carotene results in increased expression of MNX1 mRNA CTD PMID:17034753 NCBI chr 7:157,004,854...157,010,663
Ensembl chr 7:156,994,051...157,010,663
JBrowse link
G MPO myeloperoxidase multiple interactions ISO [Ascorbic Acid co-treated with beta Carotene co-treated with alpha-Tocopherol co-treated with Sodium Selenite] inhibits the reaction [Galactosamine results in increased activity of MPO protein] CTD PMID:31022331 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935
JBrowse link
G MRPL57 mitochondrial ribosomal protein L57 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of MRPL57 mRNA CTD PMID:24657404 NCBI chr13:21,176,658...21,179,084
Ensembl chr13:21,176,658...21,179,084
JBrowse link
G MSH5 mutS homolog 5 increases expression EXP beta Carotene results in increased expression of MSH5 mRNA CTD PMID:17034753 NCBI chr 6:31,740,005...31,762,676
Ensembl chr 6:31,739,677...31,762,676
JBrowse link
G MTCH2 mitochondrial carrier 2 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of MTCH2 mRNA CTD PMID:24657404 NCBI chr11:47,604,317...47,642,559
Ensembl chr11:47,617,315...47,642,607
JBrowse link
G MUC5AC mucin 5AC, oligomeric mucus/gel-forming increases expression EXP beta Carotene results in increased expression of MUC5AC mRNA CTD PMID:17034753 NCBI chr11:1,157,953...1,201,138
Ensembl chr11:1,157,953...1,201,138
JBrowse link
G NCKAP1 NCK associated protein 1 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of NCKAP1 mRNA CTD PMID:24657404 NCBI chr 2:182,909,115...183,038,457
Ensembl chr 2:182,909,115...183,038,858
JBrowse link
G NOM1 nucleolar protein with MIF4G domain 1 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of NOM1 mRNA CTD PMID:24657404 NCBI chr 7:156,949,712...156,973,176
Ensembl chr 7:156,949,712...156,973,176
JBrowse link
G NOS1 nitric oxide synthase 1 increases expression EXP beta Carotene results in increased expression of NOS1 mRNA CTD PMID:17034753 NCBI chr12:117,208,142...117,361,626
Ensembl chr12:117,208,142...117,452,170
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO [Ascorbic Acid co-treated with Vitamin E co-treated with beta Carotene co-treated with Copper] inhibits the reaction [Streptozocin results in increased expression of NOS2 mRNA] CTD PMID:18779489 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 multiple interactions
increases activity
EXP beta Carotene promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA]
beta Carotene results in increased activity of NR1I2 protein
CTD PMID:15949683 PMID:16632523 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487
JBrowse link
G OLR1 oxidized low density lipoprotein receptor 1 increases expression EXP beta Carotene results in increased expression of OLR1 mRNA CTD PMID:17034753 NCBI chr12:10,158,301...10,176,266
Ensembl chr12:10,158,301...10,172,138
JBrowse link
G PARD6A par-6 family cell polarity regulator alpha multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PARD6A mRNA CTD PMID:24657404 NCBI chr16:67,660,960...67,662,774
Ensembl chr16:67,660,946...67,662,774
JBrowse link
G PCDH1 protocadherin 1 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PCDH1 mRNA CTD PMID:24657404 NCBI chr 5:141,853,090...141,878,410
Ensembl chr 5:141,853,090...141,879,246
JBrowse link
G PCDHGC3 protocadherin gamma subfamily C, 3 increases expression EXP beta Carotene results in increased expression of PCDHGC3 mRNA CTD PMID:17034753 NCBI chr 5:141,475,966...141,512,975
Ensembl chr 5:141,475,947...141,512,977
JBrowse link
G PDGFRB platelet derived growth factor receptor beta multiple interactions ISO [alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of PDGFRB mRNA; [alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of PDGFRB protein CTD PMID:23859036 NCBI chr 5:150,113,839...150,155,845
Ensembl chr 5:150,113,839...150,155,872
JBrowse link
G PIK3R5 phosphoinositide-3-kinase regulatory subunit 5 increases expression ISO beta Carotene results in increased expression of PIK3R5 protein CTD PMID:20025956 NCBI chr17:8,878,916...8,965,707
Ensembl chr17:8,878,911...8,965,712
JBrowse link
G PLAT plasminogen activator, tissue type multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PLAT mRNA CTD PMID:24657404 NCBI chr 8:42,174,718...42,207,565
Ensembl chr 8:42,174,718...42,207,709
JBrowse link
G PLSCR1 phospholipid scramblase 1 increases expression EXP beta Carotene results in increased expression of PLSCR1 mRNA CTD PMID:17034753 NCBI chr 3:146,515,180...146,544,607
Ensembl chr 3:146,515,180...146,544,856
JBrowse link
G PLSCR3 phospholipid scramblase 3 increases expression EXP beta Carotene results in increased expression of PLSCR3 mRNA CTD PMID:17034753 NCBI chr17:7,389,727...7,394,525
Ensembl chr17:7,389,727...7,394,842
JBrowse link
G PLSCR4 phospholipid scramblase 4 increases expression EXP beta Carotene results in increased expression of PLSCR4 mRNA CTD PMID:17034753 NCBI chr 3:146,192,335...146,251,105
Ensembl chr 3:146,192,335...146,251,179
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha decreases expression ISO beta Carotene results in decreased expression of PPARA mRNA CTD PMID:21569430 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma decreases expression ISO beta Carotene results in decreased expression of PPARG mRNA CTD PMID:21569430 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G RAD51AP1 RAD51 associated protein 1 decreases expression EXP beta Carotene results in decreased expression of RAD51AP1 mRNA CTD PMID:17034753 NCBI chr12:4,538,890...4,560,047
Ensembl chr12:4,538,798...4,560,047
JBrowse link
G RAD51D RAD51 paralog D increases expression EXP beta Carotene results in increased expression of RAD51D mRNA CTD PMID:17034753 NCBI chr17:35,092,221...35,119,860
Ensembl chr17:35,092,221...35,121,522
JBrowse link
G RARA retinoic acid receptor alpha decreases expression EXP beta Carotene results in decreased expression of RARA mRNA CTD PMID:17034753 NCBI chr17:40,309,180...40,357,643
Ensembl chr17:40,309,180...40,357,643
JBrowse link
G RARB retinoic acid receptor beta increases expression EXP beta Carotene results in increased expression of RARB mRNA CTD PMID:17034753 NCBI chr 3:24,829,321...25,597,932
Ensembl chr 3:24,687,887...25,597,932
JBrowse link
G RARRES1 retinoic acid receptor responder 1 increases expression EXP beta Carotene results in increased expression of RARRES1 mRNA CTD PMID:17034753 NCBI chr 3:158,696,892...158,732,457
Ensembl chr 3:158,696,892...158,732,489
JBrowse link
G RBP4 retinol binding protein 4 multiple interactions ISO
EXP
beta Carotene results in decreased expression of and results in decreased secretion of RBP4 protein CTD PMID:22542753 NCBI chr10:93,591,694...93,601,744
Ensembl chr10:93,591,687...93,601,744
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit decreases phosphorylation EXP beta Carotene results in decreased phosphorylation of RELA protein CTD PMID:26733226 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090
JBrowse link
G RPP14 ribonuclease P/MRP subunit p14 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of RPP14 mRNA CTD PMID:24657404 NCBI chr 3:58,306,245...58,320,193
Ensembl chr 3:58,306,245...58,324,695
JBrowse link
G RRM1 ribonucleotide reductase catalytic subunit M1 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of RRM1 mRNA CTD PMID:24657404 NCBI chr11:4,094,685...4,138,932
Ensembl chr11:4,094,707...4,138,932
JBrowse link
G RXRA retinoid X receptor alpha multiple interactions EXP beta Carotene promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] CTD PMID:16632523 NCBI chr 9:134,326,455...134,440,585
Ensembl chr 9:134,317,098...134,440,585
JBrowse link
G SCARB1 scavenger receptor class B member 1 increases transport EXP SCARB1 protein results in increased transport of beta Carotene CTD PMID:16177187 NCBI chr12:124,776,856...124,863,864
Ensembl chr12:124,776,856...124,882,668
JBrowse link
G SIX6 SIX homeobox 6 increases expression EXP beta Carotene results in increased expression of SIX6 mRNA CTD PMID:17034753 NCBI chr14:60,509,146...60,512,850
Ensembl chr14:60,509,146...60,512,850
JBrowse link
G SLC2A4 solute carrier family 2 member 4 decreases expression ISO beta Carotene results in decreased expression of SLC2A4 mRNA CTD PMID:21569430 NCBI chr17:7,281,718...7,288,257
Ensembl chr17:7,281,718...7,288,257
JBrowse link
G SOD1 superoxide dismutase 1 decreases expression EXP beta Carotene results in decreased expression of SOD1 mRNA CTD PMID:17034753 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931
JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions ISO [alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of SOD2 mRNA; [Ascorbic Acid co-treated with Vitamin E co-treated with beta Carotene co-treated with Copper] inhibits the reaction [Streptozocin results in decreased expression of SOD2 mRNA]; [Ascorbic Acid co-treated with Vitamin E co-treated with beta Carotene co-treated with Copper] inhibits the reaction [Streptozocin results in decreased expression of SOD2 protein] CTD PMID:18779489 PMID:23859036 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G SPTLC2 serine palmitoyltransferase long chain base subunit 2 affects expression EXP beta Carotene affects the expression of SPTLC2 mRNA CTD PMID:17034753 NCBI chr14:77,505,997...77,616,637
Ensembl chr14:77,505,997...77,616,637
JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 increases expression EXP beta Carotene results in increased expression of SREBF1 mRNA CTD PMID:17034753 NCBI chr17:17,811,334...17,836,986
Ensembl chr17:17,810,399...17,837,002
JBrowse link
G TFCP2 transcription factor CP2 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TFCP2 mRNA CTD PMID:24657404 NCBI chr12:51,093,656...51,173,135
Ensembl chr12:51,093,656...51,173,135
JBrowse link
G TGM2 transglutaminase 2 increases expression EXP beta Carotene results in increased expression of TGM2 mRNA CTD PMID:17034753 NCBI chr20:38,127,385...38,168,475
Ensembl chr20:38,127,385...38,166,578
JBrowse link
G TGM4 transglutaminase 4 increases expression EXP beta Carotene results in increased expression of TGM4 mRNA CTD PMID:17034753 NCBI chr 3:44,874,608...44,914,990
Ensembl chr 3:44,874,608...44,914,990
JBrowse link
G THOC7 THO complex subunit 7 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of THOC7 mRNA CTD PMID:24657404 NCBI chr 3:63,833,870...63,864,484
Ensembl chr 3:63,833,870...63,863,868
JBrowse link
G TMEM209 transmembrane protein 209 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TMEM209 mRNA CTD PMID:24657404 NCBI chr 7:130,164,713...130,205,406
Ensembl chr 7:130,164,713...130,207,770
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP
ISO
beta Carotene affects the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TNF protein]; beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of TNF protein]; pyrazolanthrone inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of TNF protein]]; Quercetin affects the reaction [beta Carotene affects the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TNF protein]]; Quercetin inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of TNF protein]]
beta Carotene promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
CTD PMID:19135038 PMID:21447443 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNFRSF9 TNF receptor superfamily member 9 increases expression EXP beta Carotene results in increased expression of TNFRSF9 mRNA CTD PMID:17034753 NCBI chr 1:7,915,871...7,940,839
Ensembl chr 1:7,915,871...7,943,165
JBrowse link
G TNFSF10 TNF superfamily member 10 increases expression EXP beta Carotene results in increased expression of TNFSF10 mRNA CTD PMID:17034753 NCBI chr 3:172,505,508...172,523,430
Ensembl chr 3:172,505,508...172,523,475
JBrowse link
G TTC21B tetratricopeptide repeat domain 21B multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TTC21B mRNA CTD PMID:24657404 NCBI chr 2:165,873,362...165,953,776
Ensembl chr 2:165,857,475...165,953,851
JBrowse link
G TWF1 twinfilin actin binding protein 1 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TWF1 mRNA CTD PMID:24657404 NCBI chr12:43,793,723...43,806,317
Ensembl chr12:43,793,723...43,806,328
JBrowse link
G TXNDC9 thioredoxin domain containing 9 increases expression EXP beta Carotene results in increased expression of TXNDC9 mRNA CTD PMID:17034753 NCBI chr 2:99,306,184...99,336,333
Ensembl chr 2:99,318,982...99,340,702
JBrowse link
G TYMP thymidine phosphorylase multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TYMP mRNA CTD PMID:24657404 NCBI chr22:50,525,752...50,530,085
Ensembl chr22:50,525,752...50,530,032
JBrowse link
G VEGFA vascular endothelial growth factor A decreases expression ISO beta Carotene results in decreased expression of VEGFA mRNA CTD PMID:36819991 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link
G XRCC3 X-ray repair cross complementing 3 increases expression EXP beta Carotene results in increased expression of XRCC3 mRNA CTD PMID:17034753 NCBI chr14:103,697,617...103,715,451
Ensembl chr14:103,697,609...103,715,504
JBrowse link
G YTHDC2 YTH N6-methyladenosine RNA binding protein C2 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of YTHDC2 mRNA CTD PMID:24657404 NCBI chr 5:113,513,694...113,595,284
Ensembl chr 5:113,513,694...113,595,285
JBrowse link
G ZDHHC3 zinc finger DHHC-type palmitoyltransferase 3 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ZDHHC3 mRNA CTD PMID:24657404 NCBI chr 3:44,915,261...44,976,174
Ensembl chr 3:44,915,257...44,976,185
JBrowse link
canthaxanthin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases expression ISO Canthaxanthin results in increased expression of CYP1A1 mRNA CTD PMID:9271336 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 increases expression ISO Canthaxanthin results in increased expression of CYP1A2 mRNA CTD PMID:9271336 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
lutein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALS2 alsin Rho guanine nucleotide exchange factor ALS2 multiple interactions
decreases expression
ISO [Cisplatin co-treated with Lutein] results in decreased expression of ALS2 mRNA; [Cisplatin co-treated with Lutein] results in increased expression of ALS2 mRNA
Lutein results in decreased expression of ALS2 mRNA
CTD PMID:24865317 NCBI chr 2:201,700,267...201,780,933
Ensembl chr 2:201,700,267...201,782,112
JBrowse link
G APC APC regulator of WNT signaling pathway multiple interactions ISO [Cisplatin co-treated with Lutein] results in increased expression of APC mRNA CTD PMID:24865317 NCBI chr 5:112,707,498...112,846,239
Ensembl chr 5:112,707,518...112,846,239
JBrowse link
G AQR aquarius intron-binding spliceosomal factor decreases expression
multiple interactions
ISO Lutein results in decreased expression of AQR mRNA
[Cisplatin co-treated with Lutein] results in decreased expression of AQR mRNA
CTD PMID:24865317 NCBI chr15:34,851,782...34,969,742
Ensembl chr15:34,851,782...34,969,742
JBrowse link
G ATR ATR serine/threonine kinase multiple interactions
decreases expression
ISO [Cisplatin co-treated with Lutein] results in decreased expression of ATR mRNA
Lutein results in decreased expression of ATR mRNA
CTD PMID:24865317 NCBI chr 3:142,449,235...142,578,733
Ensembl chr 3:142,449,007...142,578,733
JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression EXP Lutein results in increased expression of BAX protein CTD PMID:17455471 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression EXP Lutein results in decreased expression of BCL2 protein CTD PMID:17455471 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2L1 BCL2 like 1 increases expression EXP Lutein results in increased expression of BCL2L1 protein CTD PMID:10750663 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G BCO2 beta-carotene oxygenase 2 increases metabolic processing
affects metabolic processing
multiple interactions
ISO BCO2 protein results in increased metabolism of Lutein
BCO2 protein affects the metabolism of Lutein
[BCO2 protein affects the metabolism of Lutein] which results in increased abundance of 3'-dehydrolutein; [BCO2 protein results in increased metabolism of Lutein] which results in increased chemical synthesis of apocarotenal metabolite
CTD PMID:21106934 NCBI chr11:112,175,512...112,218,946
Ensembl chr11:112,175,510...112,224,699
JBrowse link
G CAT catalase multiple interactions EXP Lutein inhibits the reaction [deoxynivalenol results in increased expression of CAT protein] CTD PMID:20347963 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CCND1 cyclin D1 decreases expression EXP Lutein results in decreased expression of CCND1 protein CTD PMID:17718427 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CCS copper chaperone for superoxide dismutase increases expression ISO Lutein results in increased expression of CCS mRNA CTD PMID:24865317 NCBI chr11:66,593,185...66,606,019
Ensembl chr11:66,593,153...66,606,019
JBrowse link
G CFD complement factor D decreases expression
decreases secretion
EXP Lutein results in decreased expression of CFD mRNA
Lutein results in decreased secretion of CFD protein
CTD PMID:26504594 NCBI chr19:859,664...863,641
Ensembl chr19:859,453...867,884
JBrowse link
G CKB creatine kinase B multiple interactions ISO Lutein inhibits the reaction [Isoproterenol results in increased activity of CKB protein] CTD PMID:34435724 NCBI chr14:103,519,667...103,522,830
Ensembl chr14:103,519,667...103,522,833
JBrowse link
G CTSB cathepsin B increases expression
multiple interactions
ISO Lutein results in increased expression of CTSB mRNA
Cisplatin inhibits the reaction [Lutein results in increased expression of CTSB mRNA]
CTD PMID:24865317 NCBI chr 8:11,842,524...11,868,087
Ensembl chr 8:11,842,524...11,869,533
JBrowse link
G CYBA cytochrome b-245 alpha chain multiple interactions
decreases expression
ISO [Cisplatin co-treated with Lutein] results in decreased expression of CYBA mRNA
Lutein results in decreased expression of CYBA mRNA
CTD PMID:24865317 NCBI chr16:88,643,289...88,651,053
Ensembl chr16:88,643,275...88,651,083
JBrowse link
G DES desmin multiple interactions ISO Lutein inhibits the reaction [Isoproterenol results in decreased expression of DES protein] CTD PMID:34435724 NCBI chr 2:219,418,377...219,426,734
Ensembl chr 2:219,418,377...219,426,735
JBrowse link
G ERCC2 ERCC excision repair 2, TFIIH core complex helicase subunit decreases expression
multiple interactions
ISO Lutein results in decreased expression of ERCC2 mRNA
[Cisplatin co-treated with Lutein] results in decreased expression of ERCC2 mRNA
CTD PMID:24865317 NCBI chr19:45,349,837...45,370,573
Ensembl chr19:45,349,837...45,370,918
JBrowse link
G ERCC6 ERCC excision repair 6, chromatin remodeling factor decreases expression ISO Lutein results in decreased expression of ERCC6 mRNA CTD PMID:24865317 NCBI chr10:49,434,881...49,539,538
Ensembl chr10:49,454,168...49,539,538
JBrowse link
G FMO2 flavin containing dimethylaniline monoxygenase 2 decreases expression ISO Lutein results in decreased expression of FMO2 mRNA CTD PMID:24865317 NCBI chr 1:171,185,208...171,212,686
Ensembl chr 1:171,185,249...171,212,686
JBrowse link
G GAB1 GRB2 associated binding protein 1 decreases expression
multiple interactions
ISO Lutein results in decreased expression of GAB1 mRNA
[Cisplatin co-treated with Lutein] results in decreased expression of GAB1 mRNA
CTD PMID:24865317 NCBI chr 4:143,336,876...143,474,565
Ensembl chr 4:143,336,876...143,474,565
JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions
increases expression
ISO Cisplatin inhibits the reaction [Lutein results in increased expression of GPX1 mRNA]; Lutein inhibits the reaction [Lipopolysaccharides results in decreased expression of GPX1 mRNA] CTD PMID:22040935 PMID:24865317 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,174...49,358,605
JBrowse link
G GPX2 glutathione peroxidase 2 multiple interactions ISO [Lutein co-treated with Cisplatin] results in increased expression of GPX2 mRNA CTD PMID:24865317 NCBI chr14:64,939,158...64,942,745
Ensembl chr14:64,939,152...64,942,746
JBrowse link
G GPX3 glutathione peroxidase 3 multiple interactions ISO [Cisplatin co-treated with Lutein] results in decreased expression of GPX3 mRNA CTD PMID:24865317 NCBI chr 5:151,020,591...151,028,988
Ensembl chr 5:151,020,591...151,028,988
JBrowse link
G GSR glutathione-disulfide reductase increases expression
multiple interactions
ISO Lutein results in increased expression of GSR mRNA
[Cisplatin co-treated with Lutein] results in decreased expression of GSR mRNA
CTD PMID:24865317 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G GSTK1 glutathione S-transferase kappa 1 multiple interactions ISO [Cisplatin co-treated with Lutein] results in decreased expression of GSTK1 mRNA CTD PMID:24865317 NCBI chr 7:143,263,441...143,269,115
Ensembl chr 7:143,244,093...143,270,854
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions
increases expression
ISO arsenic trioxide promotes the reaction [Lutein results in increased expression of HMOX1 mRNA]; arsenic trioxide promotes the reaction [Lutein results in increased expression of HMOX1 protein]; Lutein promotes the reaction [arsenic trioxide results in increased expression of HMOX1 mRNA]; Lutein promotes the reaction [arsenic trioxide results in increased expression of HMOX1 protein]
Lutein results in increased expression of HMOX1 mRNA; Lutein results in increased expression of HMOX1 protein
CTD PMID:25815309 PMID:26187899 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
JBrowse link
G IDH1 isocitrate dehydrogenase (NADP(+)) 1 multiple interactions
decreases expression
ISO [Cisplatin co-treated with Lutein] results in decreased expression of IDH1 mRNA
Lutein results in decreased expression of IDH1 mRNA
CTD PMID:24865317 NCBI chr 2:208,236,227...208,255,071
Ensembl chr 2:208,236,229...208,266,074
JBrowse link
G IFT172 intraflagellar transport 172 multiple interactions
decreases expression
ISO [Cisplatin co-treated with Lutein] results in decreased expression of IFT172 mRNA
Lutein results in decreased expression of IFT172 mRNA
CTD PMID:24865317 NCBI chr 2:27,444,377...27,489,743
Ensembl chr 2:27,444,377...27,489,805
JBrowse link
G INS-IGF2 INS-IGF2 readthrough multiple interactions
decreases expression
ISO [Lutein co-treated with alpha-Tocopherol] results in decreased expression of INS1 protein; [Lutein co-treated with Ascorbic Acid] results in decreased expression of INS1 protein
Lutein results in decreased expression of INS1 protein
CTD PMID:12949374 NCBI chr11:2,129,117...2,161,209
Ensembl chr11:2,132,538...2,161,209
JBrowse link
G KIF9 kinesin family member 9 multiple interactions
increases expression
ISO Lutein promotes the reaction [Cisplatin results in decreased expression of KIF9 mRNA]
Lutein results in increased expression of KIF9 mRNA
CTD PMID:24865317 NCBI chr 3:47,227,998...47,282,799
Ensembl chr 3:47,227,998...47,283,451
JBrowse link
G MB myoglobin increases expression ISO Lutein results in increased expression of MB mRNA CTD PMID:24865317 NCBI chr22:35,606,764...35,623,354
Ensembl chr22:35,606,764...35,637,951
JBrowse link
G MGST1 microsomal glutathione S-transferase 1 multiple interactions
increases expression
ISO arsenic trioxide promotes the reaction [Lutein results in increased expression of MGST1 mRNA]; Lutein promotes the reaction [arsenic trioxide results in increased expression of MGST1 mRNA] CTD PMID:25815309 PMID:26187899 NCBI chr12:16,347,115...16,593,331
Ensembl chr12:16,347,142...16,609,259
JBrowse link
G MIAT myocardial infarction associated transcript multiple interactions ISO Lutein inhibits the reaction [Isoproterenol results in increased expression of MIAT] CTD PMID:34435724 NCBI chr22:26,646,429...26,676,478
Ensembl chr22:26,646,411...26,676,478
JBrowse link
G MIR200A microRNA 200a multiple interactions ISO Lutein inhibits the reaction [Isoproterenol results in decreased expression of MIR200A mRNA] CTD PMID:34435724 NCBI chr 1:1,167,863...1,167,952
Ensembl chr 1:1,167,863...1,167,952
JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression
ISO arsenic trioxide promotes the reaction [Lutein results in increased expression of NFE2L2 mRNA]; arsenic trioxide promotes the reaction [Lutein results in increased expression of NFE2L2 protein]; Lutein promotes the reaction [arsenic trioxide results in increased expression of NFE2L2 mRNA]; Lutein promotes the reaction [arsenic trioxide results in increased expression of NFE2L2 protein]; Lutein results in increased expression of and affects the localization of NFE2L2 protein
Lutein inhibits the reaction [Isoproterenol results in decreased expression of NFE2L2 protein]
Lutein results in increased expression of NFE2L2 mRNA; Lutein results in increased expression of NFE2L2 protein
CTD PMID:25815309 PMID:26187899 PMID:34435724 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756
JBrowse link
G NGB neuroglobin increases expression ISO Lutein results in increased expression of NGB mRNA CTD PMID:24865317 NCBI chr14:77,265,483...77,271,206
Ensembl chr14:77,265,483...77,271,206
JBrowse link
G NOX4 NADPH oxidase 4 multiple interactions
decreases expression
ISO [Cisplatin co-treated with Lutein] results in decreased expression of NOX4 mRNA
Lutein results in decreased expression of NOX4 mRNA
CTD PMID:24865317 NCBI chr11:89,324,353...89,589,557
Ensembl chr11:89,324,353...89,498,187
JBrowse link
G NOXO1 NADPH oxidase organizer 1 multiple interactions ISO [Cisplatin co-treated with Lutein] results in decreased expression of NOXO1 mRNA CTD PMID:24865317 NCBI chr16:1,978,917...1,981,469
Ensembl chr16:1,978,917...1,984,192
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
ISO [Cisplatin co-treated with Lutein] results in increased expression of NQO1 mRNA; arsenic trioxide promotes the reaction [Lutein results in increased expression of NQO1 mRNA]; arsenic trioxide promotes the reaction [Lutein results in increased expression of NQO1 protein]; Lutein promotes the reaction [arsenic trioxide results in increased expression of NQO1 mRNA]; Lutein promotes the reaction [arsenic trioxide results in increased expression of NQO1 protein]
Lutein results in increased expression of NQO1 mRNA; Lutein results in increased expression of NQO1 protein
CTD PMID:24865317 PMID:25815309 PMID:26187899 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G NUDT15 nudix hydrolase 15 decreases expression
multiple interactions
ISO Lutein results in decreased expression of NUDT15 mRNA
[Cisplatin co-treated with Lutein] results in decreased expression of NUDT15 mRNA
CTD PMID:24865317 NCBI chr13:48,037,726...48,052,755
Ensembl chr13:48,037,726...48,047,221
JBrowse link
G NXN nucleoredoxin increases expression
multiple interactions
ISO Lutein results in increased expression of NXN mRNA
Lutein inhibits the reaction [Cisplatin results in increased expression of NXN mRNA]
CTD PMID:24865317 NCBI chr17:799,310...979,776
Ensembl chr17:799,310...979,776
JBrowse link
G PARK7 Parkinsonism associated deglycase multiple interactions ISO [Cisplatin co-treated with Lutein] results in decreased expression of PARK7 mRNA CTD PMID:24865317 NCBI chr 1:7,961,711...7,985,505
Ensembl chr 1:7,954,291...7,985,505
JBrowse link
G PPP1R15B protein phosphatase 1 regulatory subunit 15B multiple interactions
decreases expression
ISO [Cisplatin co-treated with Lutein] results in decreased expression of PPP1R15B mRNA
Lutein results in decreased expression of PPP1R15B mRNA
CTD PMID:24865317 NCBI chr 1:204,395,826...204,411,817
Ensembl chr 1:204,396,492...204,411,887
JBrowse link
G PRDX4 peroxiredoxin 4 increases expression ISO Lutein results in increased expression of PRDX4 mRNA CTD PMID:24865317 NCBI chr  X:23,667,493...23,686,397
Ensembl chr  X:23,664,262...23,686,397
JBrowse link
G PRDX5 peroxiredoxin 5 decreases expression ISO Lutein results in decreased expression of PRDX5 mRNA CTD PMID:24865317 NCBI chr11:64,318,121...64,321,811
Ensembl chr11:64,318,121...64,321,811
JBrowse link
G PRDX6 peroxiredoxin 6 multiple interactions
decreases expression
ISO [Cisplatin co-treated with Lutein] results in decreased expression of PRDX6 mRNA
Lutein results in decreased expression of PRDX6 mRNA
CTD PMID:24865317 NCBI chr 1:173,477,335...173,488,815
Ensembl chr 1:173,477,330...173,488,815
JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 multiple interactions ISO [Cisplatin co-treated with Lutein] results in decreased expression of PTGS1 mRNA CTD PMID:24865317 NCBI chr 9:122,370,533...122,395,703
Ensembl chr 9:122,370,530...122,395,703
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Lutein inhibits the reaction [deoxynivalenol results in increased expression of PTGS2 protein] CTD PMID:20347963 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP Lutein inhibits the reaction [deoxynivalenol affects the localization of RELA protein]; Lutein inhibits the reaction [deoxynivalenol results in increased expression of RELA protein] CTD PMID:20347963 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090
JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions
increases expression
ISO Lutein inhibits the reaction [Lipopolysaccharides results in decreased expression of SOD1 mRNA]
Lutein results in increased expression of SOD1 mRNA
CTD PMID:22040935 PMID:24865317 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931
JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions
decreases expression
ISO [Cisplatin co-treated with Lutein] results in decreased expression of SOD2 mRNA; Lutein inhibits the reaction [Lipopolysaccharides results in decreased expression of SOD2 mRNA]
Lutein results in decreased expression of SOD2 mRNA
CTD PMID:22040935 PMID:24865317 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G SOD3 superoxide dismutase 3 multiple interactions
decreases expression
ISO [Cisplatin co-treated with Lutein] results in decreased expression of SOD3 mRNA
Lutein results in decreased expression of SOD3 mRNA
CTD PMID:24865317 NCBI chr 4:24,795,573...24,800,842
Ensembl chr 4:24,789,912...24,800,842
JBrowse link
G SRXN1 sulfiredoxin 1 multiple interactions
decreases expression
ISO [Cisplatin co-treated with Lutein] results in decreased expression of SRXN1 mRNA
Lutein results in decreased expression of SRXN1 mRNA
CTD PMID:24865317 NCBI chr20:646,615...653,200
Ensembl chr20:646,615...653,200
JBrowse link
G TNNT2 troponin T2, cardiac type multiple interactions ISO Lutein inhibits the reaction [Isoproterenol results in decreased expression of TNNT2 protein] CTD PMID:34435724 NCBI chr 1:201,359,014...201,377,680
Ensembl chr 1:201,359,008...201,377,764
JBrowse link
G TXN thioredoxin multiple interactions ISO Lutein inhibits the reaction [Isoproterenol results in decreased expression of TXN protein] CTD PMID:34435724 NCBI chr 9:110,243,810...110,256,507
Ensembl chr 9:110,243,810...110,256,507
JBrowse link
G TXNIP thioredoxin interacting protein multiple interactions ISO Lutein inhibits the reaction [Isoproterenol results in increased expression of TXNIP protein] CTD PMID:34435724 NCBI chr 1:145,992,435...145,996,579
Ensembl chr 1:145,992,435...145,996,579
JBrowse link
G TXNRD1 thioredoxin reductase 1 decreases expression
multiple interactions
ISO Lutein results in decreased expression of TXNRD1 mRNA
[Cisplatin co-treated with Lutein] results in decreased expression of TXNRD1 mRNA
CTD PMID:24865317 NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307
JBrowse link
G UCP3 uncoupling protein 3 increases expression ISO Lutein results in increased expression of UCP3 mRNA CTD PMID:24865317 NCBI chr11:74,000,277...74,009,085
Ensembl chr11:74,000,277...74,009,085
JBrowse link
G VIM vimentin increases expression ISO Lutein results in increased expression of VIM mRNA CTD PMID:24865317 NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593
JBrowse link
G XIRP1 xin actin binding repeat containing 1 increases expression ISO Lutein results in increased expression of XIRP1 mRNA CTD PMID:24865317 NCBI chr 3:39,183,215...39,192,595
Ensembl chr 3:39,183,210...39,192,596
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26495
    chemical entity 26475
      atom 26471
        nonmetal atom 25731
          carbon atom 25612
            organic molecular entity 25612
              isoprenoid 14709
                terpenoid 14347
                  tetraterpenoid 609
                    carotenoid 609
                      carotenoid beta-end derivative 282
                        7,8-dihydro-beta-carotene 0
                        alpha-carotene + 61
                        beta-carotene + 241
                        beta-zeacarotene 0
                        gamma-carotene + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 26495
    subatomic particle 26471
      composite particle 26471
        hadron 26471
          baryon 26471
            nucleon 26471
              atomic nucleus 26471
                atom 26471
                  main group element atom 26207
                    main group molecular entity 26207
                      s-block molecular entity 25446
                        hydrogen molecular entity 24852
                          hydrides 23070
                            organic hydride 22029
                              organic fundamental parent 22029
                                hydrocarbon 21474
                                  terpene 14709
                                    tetraterpene 609
                                      carotene 609
                                        carotenoid 609
                                          carotenoid beta-end derivative 282
                                            7,8-dihydro-beta-carotene 0
                                            alpha-carotene + 61
                                            beta-carotene + 241
                                            beta-zeacarotene 0
                                            gamma-carotene + 0
paths to the root