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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:etazolate
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Accession:CHEBI:138502 term browser browse the term
Definition:A pyrazolopyridine that is 1H-pyrazolo[3,4-b]pyridine which is substituted at positions 1, 4, and 5 by ethyl, 2-isopropylidenehydrazino, and ethoxycarbonyl groups, respectively. A phosphodiesterase IV inhibitor with antidepressant and anxiolytic properties.
Synonyms:exact_synonym: ethyl 1-ethyl-4-(2-isopropylidenehydrazino)-1H-pyrazolo[3,4-b]pyridine-5-carboxylate
 related_synonym: 1-ethyl-4-(2-propan-2-ylidenehydrazinyl)-5-pyrazolo[3,4-b]pyridinecarboxylic acid ethyl ester;   1H-pyrazolo(3,4-b)pyridine-5-carboxylic acid, 1-ethyl-4-((1-methylethylidene)hydrazino)-, ethyl ester;   EHT-0202;   Formula=C14H19N5O2;   InChI=1S/C14H19N5O2/c1-5-19-13-10(8-16-19)12(18-17-9(3)4)11(7-15-13)14(20)21-6-2/h7-8H,5-6H2,1-4H3,(H,15,18);   InChIKey=OPQRBXUBWHDHPQ-UHFFFAOYSA-N;   SMILES=CCN1C2=NC=C(C(=C2C=N1)NN=C(C)C)C(=O)OCC;   SQ-20,009;   etazolato;   etazolatum;   ethyl 1-ethyl-4-(2-isopropylidenehydrazino)pyrazolo[3,4-b]pyridine-5-carboxylate;   ethyl 1-ethyl-4-(2-propan-2-ylidenehydrazinyl)pyrazolo[3,4-b]pyridine-5-carboxylate;   ethyl 1-ethyl-4-(2-propan-2-ylidenehydrazinyl)pyrazolo[4,5-e]pyridine-5-carboxylate;   ethyl 1-ethyl-4-[2-(1-methylethylidene)hydrazino]-1H-pyrazolo[3,4-b]pyridine-5-carboxylate
 alt_id: CHEBI:93135
 xref: CAS:51022-77-6;   Chemspider:3162;   LINCS:LSM-3446
 xref_mesh: MESH:D004974
 xref: PMID:18397369;   PMID:20223232;   PMID:22698578;   PMID:23178198;   PMID:23384434;   PMID:23926692;   PMID:23974048;   PMID:24434771;   PMID:24705918;   PMID:25120105;   PMID:25136630;   PMID:27988361;   PMID:449623;   PMID:6131949;   PMID:6132997;   PMID:6991258;   Pubchem:3277;   Reaxys:548872;   Wikipedia:Etazolate


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etazolate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il13 interleukin 13 decreases expression
decreases secretion		 ISO Etazolate results in decreased expression of IL13 mRNA
Etazolate results in decreased secretion of IL13 protein		 CTD PMID:16083514 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Ltc4s leukotriene C4 synthase decreases secretion ISO Etazolate results in decreased secretion of LTC4S protein CTD PMID:16083514 NCBI chr10:34,560,476...34,562,790
Ensembl chr10:34,560,360...34,562,651 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    role 19869
      biological role 19867
        pharmacological role 19101
          neurotransmitter agent 16813
            GABA agent 15658
              etazolate 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19835
                    p-block element atom 19835
                      chalcogen 19586
                        oxygen atom 19558
                          oxygen molecular entity 19558
                            hydroxides 19366
                              organic hydroxy compound 18975
                                alcohol 15749
                                  primary alcohol 14706
                                    ethanols 8928
                                      ethanol 8928
                                        ethyl ester 4383
                                          etazolate 2
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