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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:perfluorooctanesulfonamide
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Accession:CHEBI:138089 term browser browse the term
Definition:A perfluorinated compound that is perfluorooctane in which one of the terminal fluorines has been replace by a sulfamoyl group.
Synonyms:exact_synonym: 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane-1-sulfonamide
 related_synonym: Formula=C8H2F17NO2S;   InChI=1S/C8H2F17NO2S/c9-1(10,3(13,14)5(17,18)7(21,22)23)2(11,12)4(15,16)6(19,20)8(24,25)29(26,27)28/h(H2,26,27,28);   InChIKey=RRRXPPIDPYTNJG-UHFFFAOYSA-N;   PFOSA;   SMILES=C(C(C(C(C(C(C(C(S(N)(=O)=O)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)(F)F;   heptadecafluorooctanesulphonamide;   perfluoroctylsulfonamide;   perfluorooctane sulfonamide;   perfluorooctanesulfonic acid amide
 xref: CAS:754-91-6
 xref_mesh: MESH:C063900
 xref: PMID:16720684;   PMID:16786681;   PMID:17295423;   PMID:17384769;   PMID:18007991;   PMID:20951402;   PMID:25222623;   PMID:26053759;   PMID:27239709;   PMID:27276029;   PMID:28092384;   PMID:28350446;   Reaxys:1813858;   Wikipedia:Perfluorooctanesulfonamide


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perfluorooctanesulfonamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO perfluorooctanesulfonamide analog results in increased expression of ABCA1 mRNA; perfluorooctanesulfonamide results in increased expression of ABCA1 mRNA CTD PMID:35337807 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170 		JBrowse link
G Acaa1a acetyl-CoA acyltransferase 1A multiple interactions EXP [perfluorooctanesulfonamide results in increased activity of PPARA protein] which results in increased expression of ACAA1A mRNA; [perfluorooctanesulfonamide results in increased activity of PPARA protein] which results in increased expression of ACAA1A protein CTD PMID:15071170 NCBI chr 8:119,079,401...119,088,626
Ensembl chr 8:119,079,775...119,088,624 		JBrowse link
G Acot2 acyl-CoA thioesterase 2 increases expression ISO perfluorooctanesulfonamide analog results in increased expression of ACOT2 mRNA CTD PMID:35337807 NCBI chr 6:103,611,738...103,619,404
Ensembl chr 6:103,611,544...103,619,245 		JBrowse link
G Bdh2 3-hydroxybutyrate dehydrogenase 2 increases expression ISO perfluorooctanesulfonamide analog results in increased expression of BDH2 mRNA CTD PMID:35337807 NCBI chr 2:223,702,410...223,723,076
Ensembl chr 2:223,702,412...223,723,072 		JBrowse link
G Cdh5 cadherin 5 affects expression ISO perfluorooctanesulfonamide affects the expression of CDH5 protein CTD PMID:33677611 NCBI chr19:815,415...854,478
Ensembl chr19:815,411...854,368 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases expression ISO perfluorooctanesulfonamide analog results in increased expression of CYP7A1 mRNA CTD PMID:35337807 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase multiple interactions
increases expression		 EXP
ISO		 [perfluorooctanesulfonamide results in increased activity of PPARA protein] which results in increased expression of EHHADH mRNA
perfluorooctanesulfonamide analog results in increased expression of EHHADH mRNA		 CTD PMID:15071170 PMID:35337807 NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188 		JBrowse link
G Fasn fatty acid synthase increases expression ISO perfluorooctanesulfonamide analog results in increased expression of FASN mRNA CTD PMID:35337807 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial increases expression ISO perfluorooctanesulfonamide analog results in increased expression of GPAM mRNA; perfluorooctanesulfonamide results in increased expression of GPAM mRNA CTD PMID:35337807 NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 increases expression ISO perfluorooctanesulfonamide analog results in increased expression of GSTA1 mRNA CTD PMID:35337807 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 increases expression ISO perfluorooctanesulfonamide analog results in increased expression of GSTM3 mRNA CTD PMID:35337807 NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO perfluorooctanesulfonamide analog results in increased expression of HMGCS1 mRNA; perfluorooctanesulfonamide results in increased expression of HMGCS1 mRNA CTD PMID:35337807 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100 		JBrowse link
G Itga1 integrin subunit alpha 1 affects expression ISO perfluorooctanesulfonamide affects the expression of ITGA1 protein CTD PMID:33677611 NCBI chr 2:46,646,125...46,812,237
Ensembl chr 2:46,653,193...46,812,238 		JBrowse link
G Mmp1 matrix metallopeptidase 1 affects expression ISO perfluorooctanesulfonamide affects the expression of MMP1 protein CTD PMID:33677611 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Mttp microsomal triglyceride transfer protein increases expression ISO perfluorooctanesulfonamide analog results in increased expression of MTTP mRNA CTD PMID:35337807 NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression ISO perfluorooctanesulfonamide analog results in increased expression of NFE2L2 mRNA CTD PMID:35337807 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO perfluorooctanesulfonamide analog results in increased expression of NQO1 mRNA CTD PMID:35337807 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases expression ISO perfluorooctanesulfonamide analog results in increased expression of NR1I2 mRNA CTD PMID:35337807 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases expression ISO perfluorooctanesulfonamide analog results in increased expression of NR1I3 mRNA CTD PMID:35337807 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) increases expression ISO perfluorooctanesulfonamide analog results in increased expression of PCK2 mRNA CTD PMID:35337807 NCBI chr15:29,027,891...29,036,729
Ensembl chr15:29,027,894...29,037,283 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases activity
multiple interactions
decreases activity
increases expression		 ISO
EXP		 perfluorooctanesulfonamide results in increased activity of PPARA protein
[perfluorooctanesulfonamide results in increased activity of PPARA protein] which results in increased expression of ACAA1A mRNA; [perfluorooctanesulfonamide results in increased activity of PPARA protein] which results in increased expression of ACAA1A protein; [perfluorooctanesulfonamide results in increased activity of PPARA protein] which results in increased expression of EHHADH mRNA
perfluorooctanesulfonamide results in decreased activity of PPARA protein
perfluorooctanesulfonamide analog results in increased expression of PPARA mRNA		 CTD PMID:15071170 PMID:28857218 PMID:35337807 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO perfluorooctanesulfonamide analog results in increased expression of SCD mRNA CTD PMID:35337807 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Sod1 superoxide dismutase 1 increases expression ISO perfluorooctanesulfonamide analog results in increased expression of SOD1 mRNA CTD PMID:35337807 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression ISO perfluorooctanesulfonamide analog results in increased expression of SREBF1 mRNA; perfluorooctanesulfonamide results in increased expression of SREBF1 mRNA CTD PMID:35337807 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 increases expression ISO perfluorooctanesulfonamide analog results in increased expression of SULT2A1 mRNA CTD PMID:35337807 NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134 		JBrowse link
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Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      chemical role 19479
        environmental contaminant 18858
          persistent organic pollutant 16771
            perfluorooctanesulfonamide 25
              perfluorooctane sulfonamidoacetic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      chalcogen 19569
                        oxygen atom 19541
                          oxygen molecular entity 19541
                            hydroxides 19347
                              oxoacid 18782
                                chalcogen oxoacid 13784
                                  sulfur oxoacid 13573
                                    sulfonic acid 11618
                                      sulfonic acid derivative 11618
                                        sulfonamide 5307
                                          perfluorooctanesulfonamide 25
                                            perfluorooctane sulfonamidoacetic acid 0
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