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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:n-alk-2-enal
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Accession:CHEBI:13757 term browser browse the term
Definition:An enal obtained by formal dehydrogenation across positions 2 and 3 of any n-alkanal
Synonyms:related_synonym: Formula=C3H3OR;   SMILES=[H]C(C=C*)=O;   an alk-2-enal



show annotations for term's descendants           Sort by:
2-hexenal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b1 aldo-keto reductase family 1 member B1 affects reduction
increases reduction
ISO AKR1B1 protein affects the reduction of 2-hexenal
AKR1B1 protein results in increased reduction of 2-hexenal; AKR1B1 protein results in increased reduction of 2-hexenal metabolite
CTD PMID:9890881 PMID:11306073 PMID:21329684 NCBI chr 4:63,899,222...63,913,315 JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases reduction ISO AKR1B10 protein results in increased reduction of 2-hexenal; AKR1B10 protein results in increased reduction of 2-hexenal metabolite CTD PMID:21329684 NCBI chr 4:64,005,632...64,027,860 JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO 2-hexenal results in increased expression of AKR1C2 mRNA CTD PMID:20491607 NCBI chr17:70,669,684...70,717,935 JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases metabolic processing ISO ALDH1A1 protein results in increased metabolism of 2-hexenal CTD PMID:21256123 NCBI chr 1:218,000,470...218,152,962 JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 decreases response to substance
increases metabolic processing
affects metabolic processing
ISO ALDH3A1 protein results in decreased susceptibility to 2-hexenal
ALDH3A1 protein results in increased metabolism of 2-hexenal
ALDH3A1 protein affects the metabolism of 2-hexenal
CTD PMID:11306050 PMID:21256123 NCBI chr10:46,392,464...46,402,151 JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO 2-hexenal results in increased expression of CYP1A1 mRNA CTD PMID:20491607 NCBI chr 8:66,991,940...66,998,014 JBrowse link
G Gsta1 glutathione S-transferase alpha 1 increases expression EXP 2-hexenal results in increased expression of GSTA1 mRNA CTD PMID:9799558 NCBI chr 9:23,703,476...23,720,121 JBrowse link
G Gsta4 glutathione S-transferase alpha 4 increases expression EXP 2-hexenal results in increased expression of GSTA4 mRNA; 2-hexenal results in increased expression of GSTA4 protein CTD PMID:9799558 NCBI chr 8:79,066,967...79,084,193 JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO 2-hexenal binds to and results in decreased activity of GSTP1 protein CTD PMID:9463521 NCBI chr 1:210,767,237...210,770,242 JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO 2-hexenal results in increased expression of HMOX1 mRNA CTD PMID:20491607 NCBI chr19:13,452,365...13,479,823 JBrowse link
G Maff MAF bZIP transcription factor F increases expression ISO 2-hexenal results in increased expression of MAFF mRNA CTD PMID:20491607 NCBI chr 7:112,792,787...112,804,139 JBrowse link
G Pomc proopiomelanocortin multiple interactions EXP [2,5-dihydro-2,4,5-trimethylthiazoline co-treated with 3-hexen-1-ol co-treated with 2-hexenal] results in decreased expression of POMC protein; [3-hexen-1-ol co-treated with 2-hexenal] inhibits the reaction [2,5-dihydro-2,4,5-trimethylthiazoline results in decreased expression of POMC protein]; [3-hexen-1-ol co-treated with 2-hexenal] results in decreased expression of POMC CTD PMID:19103229 PMID:21515296 NCBI chr 6:32,659,137...32,665,175 JBrowse link
G Ptgr1 prostaglandin reductase 1 multiple interactions EXP [PTGR1 protein co-treated with NADP] affects the reduction of 2-hexenal CTD PMID:11524419 NCBI chr 5:78,579,060...78,597,671 JBrowse link
hept-2-enal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b1 aldo-keto reductase family 1 member B1 increases reduction ISO AKR1B1 protein results in increased reduction of 2-heptenal CTD PMID:9890881 NCBI chr 4:63,899,222...63,913,315 JBrowse link
non-2-enal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b1 aldo-keto reductase family 1 member B1 increases reduction
affects reduction
ISO AKR1B1 protein results in increased reduction of 2-nonenal
AKR1B1 protein affects the reduction of 2-nonenal
CTD PMID:9890881 PMID:11306073 NCBI chr 4:63,899,222...63,913,315 JBrowse link
G Akr7a2 aldo-keto reductase family 7, member A2 decreases response to substance ISO AKR7A5 protein results in decreased susceptibility to 2-nonenal CTD PMID:24590062 NCBI chr 5:151,552,375...151,560,914 JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 decreases response to substance ISO ALDH1A1 protein results in decreased susceptibility to 2-nonenal CTD PMID:11306050 NCBI chr 1:218,000,470...218,152,962 JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 affects metabolic processing
decreases response to substance
ISO ALDH3A1 protein affects the metabolism of 2-nonenal
ALDH3A1 protein results in decreased susceptibility to 2-nonenal
CTD PMID:11306050 NCBI chr10:46,392,464...46,402,151 JBrowse link
G Gstm5 glutathione S-transferase, mu 5 decreases metabolic processing
increases metabolic processing
ISO GSTM3 protein polymorphism results in decreased metabolism of 2-nonenal
GSTM3 protein polymorphism results in increased metabolism of 2-nonenal
CTD PMID:15247628 NCBI chr 2:195,531,599...195,534,562 JBrowse link
G Ptgr1 prostaglandin reductase 1 multiple interactions EXP [PTGR1 protein co-treated with NADP] affects the reduction of 2-nonenal CTD PMID:11524419 NCBI chr 5:78,579,060...78,597,671 JBrowse link
oct-2-enal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b1 aldo-keto reductase family 1 member B1 increases reduction
affects reduction
ISO AKR1B1 protein results in increased reduction of 2-octenal
AKR1B1 protein affects the reduction of 2-octenal
CTD PMID:9890881 PMID:11306073 NCBI chr 4:63,899,222...63,913,315 JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 affects metabolic processing
decreases response to substance
ISO ALDH3A1 protein affects the metabolism of 2-octenal
ALDH3A1 protein results in decreased susceptibility to 2-octenal
CTD PMID:11306050 NCBI chr10:46,392,464...46,402,151 JBrowse link
G Aldh3b1 aldehyde dehydrogenase 3 family, member B1 decreases response to substance ISO ALDH3B1 protein results in decreased susceptibility to 2-octenal CTD PMID:20699116 NCBI chr 1:201,145,309...201,162,675 JBrowse link
G Ptgr1 prostaglandin reductase 1 multiple interactions EXP [PTGR1 protein co-treated with NADP] affects the reduction of 2-octenal CTD PMID:11524419 NCBI chr 5:78,579,060...78,597,671 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    chemical entity 19896
      atom 19896
        nonmetal atom 19818
          carbon atom 19770
            organic molecular entity 19770
              olefinic compound 16992
                enal 3111
                  n-alk-2-enal 16
                    2-hexadecenal + 0
                    2-hexenal + 13
                    2-undecenal + 0
                    hept-2-enal 1
                    non-2-enal 6
                    oct-2-enal + 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19770
                          organic molecular entity 19770
                            heteroorganic entity 19535
                              organochalcogen compound 19296
                                organooxygen compound 19213
                                  carbon oxoacid 18682
                                    carboxylic acid 18679
                                      carboacyl group 17726
                                        univalent carboacyl group 17726
                                          formyl group 9386
                                            aldehyde 9386
                                              alpha,beta-unsaturated aldehyde 3111
                                                enal 3111
                                                  n-alk-2-enal 16
                                                    2-hexadecenal + 0
                                                    2-hexenal + 13
                                                    2-undecenal + 0
                                                    hept-2-enal 1
                                                    non-2-enal 6
                                                    oct-2-enal + 4
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