secondary ammonium ion - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	secondary ammonium ion	go back to main search page
Accession:	CHEBI:137419	browse the term
Definition:	An organic cation obtained by protonation of any secondary amino compound; major species at pH 7.3.
Synonyms:	related_synonym:	Formula=H2NR2; SMILES=[NH+]()[H]; a secondary amine; secondary amine(1+)
	xref:	MetaCyc:Secondary-Amines
	cyclic_relationship:	is_conjugate_acid_of CHEBI:32863

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Genes (103)

dizocilpine maleate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adenosine A3 receptor

multiple interactions

[N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein] which results in decreased susceptibility to Dizocilpine Maleate

NCBI chr 2:193,352,759...193,392,946
Ensembl chr 2:193,388,713...193,392,357

G

adenosylhomocysteinase-like 2

increases expression

Dizocilpine Maleate results in increased expression of AHCYL2 protein

NCBI chr 4:58,381,290...58,531,061
Ensembl chr 4:58,381,218...58,531,060

G

aryl hydrocarbon receptor

multiple interactions

Dizocilpine Maleate inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 promoter]]

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

apoptosis inducing factor, mitochondria associated 1

multiple interactions

Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists affects the localization of AIFM1 protein]

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

G

aldolase, fructose-bisphosphate C

increases expression

Dizocilpine Maleate results in increased expression of ALDOC protein

NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066

G

amyloid beta precursor protein

multiple interactions

Dizocilpine Maleate inhibits the reaction [Pentylenetetrazole results in increased expression of APP mRNA]

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

activity-regulated cytoskeleton-associated protein

multiple interactions

Dizocilpine Maleate inhibits the reaction [phosphinothricin results in increased expression of ARC mRNA]

NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

Dizocilpine Maleate results in increased expression of BAX protein
Dizocilpine Maleate inhibits the reaction [Dextromethorphan results in increased expression of BAX protein]; Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists results in increased expression of BAX protein]

PMID:19201465 PMID:19759125 PMID:25937004 PMID:28916251

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression
multiple interactions

Dizocilpine Maleate results in decreased expression of BCL2 protein
Dizocilpine Maleate inhibits the reaction [decabromobiphenyl ether results in decreased expression of BCL2 protein]
Dizocilpine Maleate inhibits the reaction [Cocaine results in increased phosphorylation of BCL2 protein]

PMID:10859492 PMID:19879923 PMID:29151189

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

multiple interactions

Dizocilpine Maleate inhibits the reaction [Dextromethorphan results in decreased expression of BCL2L1 protein]

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

brain-derived neurotrophic factor

decreases expression
multiple interactions
affects expression

Dizocilpine Maleate results in decreased expression of BDNF mRNA
Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased expression of and results in increased localization of BDNF mRNA]; Pentobarbital inhibits the reaction [Dizocilpine Maleate affects the expression of BDNF mRNA]; Scopolamine inhibits the reaction [Dizocilpine Maleate affects the expression of BDNF mRNA]

PMID:8247360 PMID:8405262 PMID:15282290

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

calcium/calmodulin-dependent protein kinase II alpha

multiple interactions

Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agents promotes the reaction [CAMK2A protein binds to DRD3 protein]]

NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994

G

calcium/calmodulin-dependent protein kinase IV

multiple interactions

Dizocilpine Maleate inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of CAMK4 protein]

NCBI chr18:24,582,988...24,811,918
Ensembl chr18:24,585,269...24,802,487

G

caspase 3

multiple interactions
increases activity
increases expression

Dizocilpine Maleate inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased cleavage of CASP3 protein]; Dizocilpine Maleate inhibits the reaction [D-Aspartic Acid results in increased activity of and results in increased cleavage of CASP3 protein]; Dizocilpine Maleate inhibits the reaction [Dextromethorphan results in increased cleavage of CASP3 protein]; Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased cleavage of CASP3 protein]
Dizocilpine Maleate results in increased activity of CASP3 protein
Dizocilpine Maleate results in increased expression of CASP3 protein modified form

PMID:19759125 PMID:21873648 PMID:22824136 PMID:25937004 PMID:28916251 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

increases activity

Dizocilpine Maleate results in increased activity of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions

[bastadin 12 co-treated with Ryanodine co-treated with Dizocilpine Maleate] inhibits the reaction [tetrabromobisphenol A results in decreased activity of CAT protein]; Dizocilpine Maleate inhibits the reaction [ammonium acetate results in decreased activity of CAT protein]

PMID:12885441 PMID:27718046

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cholecystokinin

multiple interactions
decreases expression

Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CCK mRNA]; Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CCK protein]
Dizocilpine Maleate results in decreased expression of CCK mRNA; Dizocilpine Maleate results in decreased expression of CCK protein

NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084

G

choline O-acetyltransferase

multiple interactions

Dizocilpine Maleate inhibits the reaction [Quinolinic Acid results in decreased activity of CHAT protein]

NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093

G

cannabinoid receptor 1

affects response to substance

CNR1 protein affects the susceptibility to Dizocilpine Maleate

NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099

G

collagen type I alpha 1 chain

multiple interactions
increases expression

Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists results in increased expression of COL1A1 mRNA]
Dizocilpine Maleate results in increased expression of COL1A1 mRNA

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collagen type III alpha 1 chain

multiple interactions

Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists results in increased expression of COL3A1 mRNA]

NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547

G

cAMP responsive element binding protein 1

increases phosphorylation
multiple interactions
decreases phosphorylation

Dizocilpine Maleate results in increased phosphorylation of CREB1 protein
Dizocilpine Maleate inhibits the reaction [Sodium Glutamate results in increased expression of CREB1 mRNA]
Dizocilpine Maleate inhibits the reaction [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased phosphorylation of CREB1 protein]; Dizocilpine Maleate inhibits the reaction [Dopamine results in increased phosphorylation of CREB1 protein]; Dizocilpine Maleate inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CREB1 protein binds to CYP1A1 promoter]]
Dizocilpine Maleate inhibits the reaction [Formaldehyde results in increased expression of CREB1 mRNA]
Dizocilpine Maleate results in decreased phosphorylation of CREB1 protein

PMID:14622123 PMID:15877933 PMID:17434604 PMID:17973980 PMID:31981724

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

catenin beta 1

decreases expression
multiple interactions

Dizocilpine Maleate results in decreased expression of CTNNB1 mRNA
Famotidine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CTNNB1 mRNA]; Olanzapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CTNNB1 mRNA]

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

C-X-C motif chemokine ligand 2

multiple interactions

Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists results in decreased activity of CXCL2 protein]

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

Dizocilpine Maleate inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 promoter]]; Dizocilpine Maleate inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CREB1 protein binds to CYP1A1 promoter]]

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 46, subfamily a, polypeptide 1

multiple interactions

Dizocilpine Maleate inhibits the reaction [Sodium Glutamate results in increased expression of CYP46A1 mRNA]; Dizocilpine Maleate inhibits the reaction [Sodium Glutamate results in increased expression of CYP46A1 protein]

NCBI chr 6:127,247,543...127,274,765
Ensembl chr 6:127,243,315...127,274,760

G

discs large MAGUK scaffold protein 1

increases expression

Dizocilpine Maleate results in increased expression of DLG1 mRNA

NCBI chr11:68,911,883...69,103,230
Ensembl chr11:68,911,883...69,102,689

G

discs large MAGUK scaffold protein 4

increases expression

Dizocilpine Maleate results in increased expression of DLG4 mRNA

NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153

G

dynamin 1-like

multiple interactions

Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists results in decreased expression of DNM1L protein]

NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482

G

dopamine receptor D1

multiple interactions

[[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Dizocilpine Maleate] co-treated with [1-hydroxy-3-amino-2-pyrrolidone results in increased activity of DRD1 protein]] results in increased susceptibility to Pilocarpine; Dizocilpine Maleate inhibits the reaction [Formaldehyde results in increased expression of DRD1 mRNA]

PMID:7906944 PMID:17434604

NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002

G

dopamine receptor D2

multiple interactions

Dizocilpine Maleate inhibits the reaction [Formaldehyde results in increased expression of DRD2 mRNA]

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

G

dopamine receptor D3

multiple interactions

Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agents promotes the reaction [CAMK2A protein binds to DRD3 protein]]

NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596

G

dual specificity phosphatase 1

multiple interactions

Dizocilpine Maleate inhibits the reaction [Methamphetamine results in increased expression of DUSP1 mRNA]

NCBI chr10:16,680,478...16,683,275

G

dual specificity phosphatase 6

multiple interactions

Dizocilpine Maleate inhibits the reaction [Methamphetamine results in increased expression of DUSP6 mRNA]

NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185

G

early growth response 1

multiple interactions

Dizocilpine Maleate inhibits the reaction [Zinc results in increased expression of EGR1 protein]

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions

Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of EIF2AK3 protein]

NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911

G

ectonucleotide pyrophosphatase/phosphodiesterase 2

multiple interactions

Dizocilpine Maleate inhibits the reaction [[ENPP2 protein co-treated with Capsaicin] results in increased abundance of lysophosphatidic acid]

NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827

G

endoplasmic reticulum to nucleus signaling 1

multiple interactions

Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of ERN1 protein]

NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029

G

fatty acid amide hydrolase

decreases activity

Dizocilpine Maleate results in decreased activity of FAAH protein

NCBI chr 5:129,479,774...129,499,018
Ensembl chr 5:129,479,824...129,498,677

G

fibroblast growth factor 2

increases expression

Dizocilpine Maleate results in increased expression of FGF2 mRNA

NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
decreases expression
increases expression

[Morphine co-treated with Dizocilpine Maleate] inhibits the reaction [Naloxone results in increased expression of FOS protein]; Dizocilpine Maleate inhibits the reaction [[Kainic Acid co-treated with dihydroxyethyldithiocarbamate] results in increased expression of FOS protein]; Dizocilpine Maleate inhibits the reaction [Haloperidol results in increased expression of FOS protein]
Dizocilpine Maleate results in decreased expression of FOS mRNA; Dizocilpine Maleate results in decreased expression of FOS protein
Dizocilpine Maleate results in increased expression of FOS mRNA
Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of FOS protein]; Dizocilpine Maleate inhibits the reaction [Dextroamphetamine results in increased expression of FOS mRNA]; Dizocilpine Maleate inhibits the reaction [Dextromethorphan results in increased expression of FOS protein]; Dizocilpine Maleate inhibits the reaction [Pentylenetetrazole results in increased expression of FOS protein]; Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA]

PMID:7984056 PMID:8404677 PMID:11421588 PMID:12401322 PMID:12807422 More...

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

FosB proto-oncogene, AP-1 transcription factor subunit

increases response to substance

FOSB protein modified form results in increased susceptibility to Dizocilpine Maleate

NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465

G

glutamate decarboxylase 1

multiple interactions

Dizocilpine Maleate inhibits the reaction [Oxygen deficiency results in decreased expression of GAD1 protein]

NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333

G

galanin and GMAP prepropeptide

multiple interactions

Dizocilpine Maleate inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of GAL mRNA]

NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959

G

growth associated protein 43

multiple interactions

Dizocilpine Maleate inhibits the reaction [Kainic Acid results in increased expression of GAP43 mRNA]

NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045

G

glyceraldehyde-3-phosphate dehydrogenase

increases expression

Dizocilpine Maleate results in increased expression of GAPDH protein

NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235

G

glial fibrillary acidic protein

multiple interactions

Dizocilpine Maleate inhibits the reaction [diphenylditelluride results in decreased phosphorylation of GFAP protein]

NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589

G

glutamate ionotropic receptor AMPA type subunit 1

multiple interactions

Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of GRIA1 protein]

NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283

G

glutamate ionotropic receptor NMDA type subunit 1

decreases activity
affects binding
increases expression
multiple interactions

Dizocilpine Maleate results in decreased activity of GRIN1 protein
Dizocilpine Maleate binds to GRIN1 protein
Dizocilpine Maleate results in increased expression of GRIN1 mRNA
[GRIN1 protein co-treated with GRIN2A protein] results in increased susceptibility to Dizocilpine Maleate; [GRIN1 protein co-treated with GRIN2B protein] results in increased susceptibility to Dizocilpine Maleate; Dizocilpine Maleate inhibits the reaction [[GRIN1 protein co-treated with GRIN2A protein] results in increased susceptibility to Excitatory Amino Acid Agonists]
Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of GRIN1 protein]; Dizocilpine Maleate inhibits the reaction [Folic Acid deficiency results in increased expression of GRIN1 protein]; Dizocilpine Maleate promotes the reaction [GRIN1 protein binds to SRC protein]

PMID:11249956 PMID:11801363 PMID:19224577 PMID:19788891 PMID:20406136 More...

NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603

G

glutamate ionotropic receptor NMDA type subunit 2A

multiple interactions
increases phosphorylation

Dizocilpine Maleate inhibits the reaction [Formaldehyde results in increased expression of GRIN2A mRNA]
Dizocilpine Maleate results in increased phosphorylation of GRIN2A protein
[GRIN1 protein co-treated with GRIN2A protein] results in increased susceptibility to Dizocilpine Maleate; Dizocilpine Maleate inhibits the reaction [[GRIN1 protein co-treated with GRIN2A protein] results in increased susceptibility to Excitatory Amino Acid Agonists]
Dizocilpine Maleate inhibits the reaction [Folic Acid deficiency results in increased expression of GRIN2A protein]

PMID:11249956 PMID:17434604 PMID:19224577 PMID:20406136

NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637

G

glutamate ionotropic receptor NMDA type subunit 2B

multiple interactions
decreases expression

Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of GRIN2B protein]; Dizocilpine Maleate inhibits the reaction [Dextromethorphan results in increased expression of GRIN2B protein]
Dizocilpine Maleate results in decreased expression of GRIN2B mRNA
[GRIN1 protein co-treated with GRIN2B protein] results in increased susceptibility to Dizocilpine Maleate

PMID:11169168 PMID:11801363 PMID:19224577 PMID:28916251

NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279

G

glutamate ionotropic receptor NMDA type subunit 2C

decreases expression

Dizocilpine Maleate results in decreased expression of GRIN2C mRNA

NCBI chr10:100,488,430...100,507,083
Ensembl chr10:100,488,431...100,506,427

G

glycogen synthase kinase 3 beta

multiple interactions
increases phosphorylation
increases expression

3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Dizocilpine Maleate results in decreased phosphorylation of and results in increased activity of GSK3B protein]; Dizocilpine Maleate results in decreased phosphorylation of and results in increased activity of GSK3B protein; Famotidine inhibits the reaction [Dizocilpine Maleate results in decreased phosphorylation of and results in increased activity of GSK3B protein]; Famotidine inhibits the reaction [Dizocilpine Maleate results in increased expression of GSK3B mRNA]; Olanzapine inhibits the reaction [Dizocilpine Maleate results in increased expression of GSK3B mRNA]
Dizocilpine Maleate results in increased phosphorylation of GSK3B protein

PMID:15877933 PMID:31563592

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

heat shock protein family A (Hsp70) member 1A

multiple interactions

Dizocilpine Maleate inhibits the reaction [[Kainic Acid co-treated with dihydroxyethyldithiocarbamate] results in increased expression of HSPA1A protein]

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 5

multiple interactions

Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of HSPA5 protein]

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

interleukin 1 beta

multiple interactions

Dizocilpine Maleate inhibits the reaction [Ibotenic Acid results in increased expression of IL1B protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

Dizocilpine Maleate inhibits the reaction [Ibotenic Acid results in increased expression of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

inhibin subunit beta A

multiple interactions

Dizocilpine Maleate inhibits the reaction [Ibotenic Acid results in increased expression of INHBA protein]

NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased expression of JUN mRNA]

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

JunB proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Dizocilpine Maleate inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of JUNB mRNA]; Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA]

PMID:7984056 PMID:9890435

NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035

G

monoamine oxidase A

multiple interactions

Dizocilpine Maleate inhibits the reaction [ammonium acetate results in increased activity of MAOA protein]

NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593

G

mitogen activated protein kinase 1

multiple interactions
decreases phosphorylation

[Dizocilpine Maleate co-treated with 2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline] inhibits the reaction [Dieldrin results in increased phosphorylation of MAPK1 protein]; Dizocilpine Maleate affects the reaction [Ptychodiscus brevis T2 toxin affects the phosphorylation of MAPK1 protein]; Dizocilpine Maleate inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] results in increased activity of and results in increased phosphorylation of MAPK1 protein]; Dizocilpine Maleate inhibits the reaction [Dronabinol results in increased activity of MAPK1 protein]; Dizocilpine Maleate inhibits the reaction [Dronabinol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Dizocilpine Maleate inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Dizocilpine Maleate results in decreased phosphorylation of and results in decreased activity of MAPK1 protein
Dizocilpine Maleate results in decreased phosphorylation of MAPK1 protein
Dizocilpine Maleate inhibits the reaction [Ammonium Chloride results in increased phosphorylation of MAPK1 protein]; Dizocilpine Maleate inhibits the reaction [Capsaicin results in increased phosphorylation of MAPK1 protein]
Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists results in increased phosphorylation of MAPK1 protein]

PMID:11553284 PMID:11923223 PMID:12657697 PMID:15086530 PMID:15385614 More...

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

decreases phosphorylation
multiple interactions

Dizocilpine Maleate results in decreased phosphorylation of MAPK3 protein
[Dizocilpine Maleate co-treated with 2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline] inhibits the reaction [Dieldrin results in increased phosphorylation of MAPK3 protein]; Dizocilpine Maleate affects the reaction [Ptychodiscus brevis T2 toxin affects the phosphorylation of MAPK3 protein]; Dizocilpine Maleate inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] results in increased activity of and results in increased phosphorylation of MAPK3 protein]; Dizocilpine Maleate inhibits the reaction [Dronabinol results in increased activity of MAPK3 protein]; Dizocilpine Maleate inhibits the reaction [Dronabinol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Dizocilpine Maleate inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Dizocilpine Maleate results in decreased phosphorylation of and results in decreased activity of MAPK3 protein
Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists results in increased phosphorylation of MAPK3 protein]
Dizocilpine Maleate inhibits the reaction [Ammonium Chloride results in increased phosphorylation of MAPK3 protein]; Dizocilpine Maleate inhibits the reaction [Capsaicin results in increased phosphorylation of MAPK3 protein]

PMID:11553284 PMID:11923223 PMID:12657697 PMID:15086530 PMID:15385614 More...

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

microtubule-associated protein tau

multiple interactions

Dizocilpine Maleate inhibits the reaction [Methylmercury Compounds results in increased phosphorylation of MAPT protein]
Dizocilpine Maleate inhibits the reaction [D-Aspartic Acid results in decreased expression of and affects the phosphorylation of MAPT protein]; Dizocilpine Maleate inhibits the reaction [D-Aspartic Acid results in decreased phosphorylation of MAPT protein]; Dizocilpine Maleate inhibits the reaction [D-Aspartic Acid results in increased cleavage of MAPT protein]

PMID:21976409 PMID:30822420

NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129

G

mitofusin 2

multiple interactions

Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists results in decreased expression of MFN2 protein]

NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342

G

matrix metallopeptidase 1

multiple interactions

Dizocilpine Maleate inhibits the reaction [Folic Acid deficiency results in decreased expression of MMP1 mRNA]; Dizocilpine Maleate inhibits the reaction [Homocysteine analog results in decreased expression of and results in decreased activity of MMP1 protein]

NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097

G

matrix metallopeptidase 9

multiple interactions

Dizocilpine Maleate inhibits the reaction [Folic Acid deficiency results in decreased expression of MMP9 mRNA]; Dizocilpine Maleate inhibits the reaction [Homocysteine analog results in decreased expression of MMP9 protein]

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

neurofilament light chain

multiple interactions

Dizocilpine Maleate inhibits the reaction [diphenylditelluride results in decreased phosphorylation of NEFL protein]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of NEFL mRNA]; Dizocilpine Maleate inhibits the reaction [Rotenone results in decreased expression of NEFL mRNA]

PMID:21863293 PMID:31969611

NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793

G

neurofilament medium chain

multiple interactions

Dizocilpine Maleate inhibits the reaction [diphenylditelluride results in decreased phosphorylation of NEFM protein]

NCBI chr15:42,360,449...42,365,753
Ensembl chr15:42,360,454...42,365,755

G

NFKB inhibitor alpha

multiple interactions

Dizocilpine Maleate inhibits the reaction [Ammonium Chloride results in increased degradation of NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

NME/NM23 nucleoside diphosphate kinase 1

increases expression

Dizocilpine Maleate results in increased expression of NME1 protein

NCBI chr10:78,907,036...78,929,659
Ensembl chr10:78,906,083...78,916,408

G

nitric oxide synthase 1

multiple interactions

Dizocilpine Maleate inhibits the reaction [decabromobiphenyl ether results in increased expression of NOS1 protein]

NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945

G

nitric oxide synthase 2

multiple interactions

Dizocilpine Maleate inhibits the reaction [Ammonium Chloride results in increased expression of NOS2 protein]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

neuropeptide S

decreases activity
multiple interactions

NPS protein results in decreased activity of Dizocilpine Maleate
3-oxo-1,1-diphenyltetrahydrooxazolo(3,4-a)pyrazine-7-carboxylic acid 4-fluorobenzylamide inhibits the reaction [NPS protein results in decreased activity of Dizocilpine Maleate]

NCBI chr 1:190,077,040...190,080,821
Ensembl chr 1:190,077,040...190,080,821

G

N-ethylmaleimide sensitive factor, vesicle fusing ATPase

increases expression

Dizocilpine Maleate results in increased expression of NSF protein

NCBI chr10:88,727,912...88,857,375
Ensembl chr10:88,727,912...88,857,386

G

occludin

multiple interactions

Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists results in decreased expression of OCLN protein]

NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150

G

opioid receptor, mu 1

multiple interactions

Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]]; Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]

NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409

G

poly (ADP-ribose) polymerase 1

multiple interactions

Dizocilpine Maleate inhibits the reaction [ammonium acetate results in increased expression of PARP1 protein]

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

phosphodiesterase 2A

multiple interactions

Dizocilpine Maleate inhibits the reaction [decabromobiphenyl ether results in increased expression of PDE2A mRNA]

NCBI chr 1:155,823,590...155,915,434
Ensembl chr 1:155,813,180...155,915,434

G

phosphodiesterase 5A

multiple interactions

Dizocilpine Maleate inhibits the reaction [decabromobiphenyl ether results in increased expression of PDE5A mRNA]

NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701

G

proenkephalin

multiple interactions

Dizocilpine Maleate inhibits the reaction [Amphetamine results in increased expression of PENK mRNA]

NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129

G

proopiomelanocortin

multiple interactions

Dizocilpine Maleate inhibits the reaction [Capsaicin results in increased secretion of POMC protein]

NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664

G

protein kinase C, alpha

multiple interactions

Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]]

NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012

G

protein kinase C, gamma

increases expression
multiple interactions

Dizocilpine Maleate results in increased expression of PRKCG mRNA
Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]

PMID:11169168 PMID:18652891

NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384

G

prolactin

decreases expression

Dizocilpine Maleate results in decreased expression of PRL protein

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

proline dehydrogenase

affects response to substance

PRODH protein affects the susceptibility to Dizocilpine Maleate

NCBI chr11:82,910,043...82,927,305
Ensembl chr11:82,910,137...82,927,305

G

prostaglandin-endoperoxide synthase 2

multiple interactions

Dizocilpine Maleate inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

pleiotrophin

multiple interactions

Dizocilpine Maleate promotes the reaction [Amphetamine results in increased expression of PTN mRNA]

NCBI chr 4:65,293,731...65,375,572
Ensembl chr 4:65,293,734...65,375,456

G

Rac family small GTPase 1

multiple interactions

Dizocilpine Maleate inhibits the reaction [bisphenol A results in increased expression of RAC1 protein]; Dizocilpine Maleate inhibits the reaction [Estradiol results in increased expression of RAC1 protein]

NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251

G

retinoic acid receptor, alpha

multiple interactions

Dizocilpine Maleate inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [Alitretinoin results in increased activity of RARA protein]]

NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142

G

ras homolog family member A

multiple interactions

Dizocilpine Maleate inhibits the reaction [bisphenol A results in decreased expression of RHOA protein]; Dizocilpine Maleate inhibits the reaction [Estradiol results in decreased expression of RHOA protein]

NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746

G

sirtuin 1

multiple interactions

Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

G

superoxide dismutase 2

multiple interactions

Dizocilpine Maleate inhibits the reaction [ammonium acetate results in decreased activity of SOD2 protein]

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

SRC proto-oncogene, non-receptor tyrosine kinase

multiple interactions
increases activity
increases expression

Dizocilpine Maleate promotes the reaction [GRIN1 protein binds to SRC protein]; Dizocilpine Maleate results in increased phosphorylation of and results in increased activity of SRC protein
Dizocilpine Maleate results in increased activity of SRC protein
Dizocilpine Maleate results in increased expression of SRC mRNA; Dizocilpine Maleate results in increased expression of SRC protein

NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476

G

somatostatin

decreases expression
multiple interactions

Dizocilpine Maleate results in decreased expression of SST mRNA; Dizocilpine Maleate results in decreased expression of SST protein
Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of SST mRNA]; Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of SST protein]

NCBI chr11:76,956,896...76,958,173
Ensembl chr11:76,956,896...76,958,173

G

tachykinin, precursor 1

multiple interactions

Dizocilpine Maleate inhibits the reaction [[Lithium co-treated with Pilocarpine] results in increased expression of TAC1 protein modified form]

NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178

G

transforming growth factor alpha

multiple interactions

Dizocilpine Maleate inhibits the reaction [Lipopolysaccharides results in increased secretion of TGFA]

NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894

G

TIMP metallopeptidase inhibitor 1

multiple interactions

Dizocilpine Maleate inhibits the reaction [Homocysteine analog results in increased expression of TIMP1 mRNA]; Dizocilpine Maleate inhibits the reaction [Homocysteine analog results in increased expression of TIMP1 protein]

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

tight junction protein 1

multiple interactions

Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of TJP1 mRNA]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of TJP1 protein]

NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432

G

triosephosphate isomerase 1

increases expression

Dizocilpine Maleate results in increased expression of TPI1 protein

NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541

G

vimentin

multiple interactions

Dizocilpine Maleate inhibits the reaction [diphenylditelluride results in decreased phosphorylation of VIM protein]

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

G

xanthine dehydrogenase

multiple interactions

Dizocilpine Maleate inhibits the reaction [ammonium acetate affects the activity of XDH protein]

NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268

pentolinium tartrate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

insulin 2

multiple interactions

Pentolinium Tartrate inhibits the reaction [Epinephrine results in decreased secretion of INS protein]

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19898
chemical entity	19896
molecular entity	19896
ion	17094
organic ion	11451
organic cation	8962
secondary ammonium ion	103
(1S,7R,8R,14S)-6,9-dioxo-15,17-diazatetracyclo[12.2.2.1(3,7).1(8,12)]icosa-3(20),12(19)-dien-15-ium	0
(R)-salsolinol(1+)	0
(S)-norreticuline(1+)	0
N,N'-bis(diphenylmethyl)ethane-1,2-diamine(2+) +	0
N,N-dimethyl-cadaverine(+2)	0
N-(D-erythrulosyl)-cadaverine(2+)	0
N-[2-chloro-2-(naphthalen-2-yl)ethyl]propan-2-aminium +	0
N-methyl-2-methylpropan-1-aminium	0
N-methylmescalinium	0
N-methyltryptaminium	0
aculene A(1+)	0
aculene B(1+)	0
ciprofloxacin(1+)	0
dilevalol(1+) +	0
dizocilpine(1+) +	102
ent-tamsulosin(1+) +	0
fasudil(1+) +	0
heliamine(1+) +	0
herquline B(1+)	0
herquline C(1+)	0
mefuparib(1+) +	0
methamphetamine(1+) +	0
morpholinium	0
nirogacestat(2+) +	0
norreticuline(1+) +	0
norsalsolinol(1+)	0
perivine(1+)	0
piperidinium	0
pyrrolidinium ion +	1
secondary aliphatic ammonium ion +	0
solasodine 3-beta-D-glucoside(1+)	0
solasodine(1+)	0
spectinomycin(1+)	0
tamsulosin(1+) +	0
tomatidine(1+)	0
validoxylamine B(1+)	0
Path 2
Term	Annotations
CHEBI ontology	19898
subatomic particle	19896
composite particle	19896
hadron	19896
baryon	19896
nucleon	19896
atomic nucleus	19896
atom	19896
main group element atom	19835
main group molecular entity	19835
s-block molecular entity	19670
hydrogen molecular entity	19651
hydrides	19158
inorganic hydride	18176
pnictogen hydride	18166
nitrogen hydride	18079
ammonium	8322
ammonium ion derivative	8317
secondary ammonium ion	103
(1S,7R,8R,14S)-6,9-dioxo-15,17-diazatetracyclo[12.2.2.1(3,7).1(8,12)]icosa-3(20),12(19)-dien-15-ium	0
(R)-salsolinol(1+)	0
(S)-norreticuline(1+)	0
N,N'-bis(diphenylmethyl)ethane-1,2-diamine(2+) +	0
N,N-dimethyl-cadaverine(+2)	0
N-(D-erythrulosyl)-cadaverine(2+)	0
N-[2-chloro-2-(naphthalen-2-yl)ethyl]propan-2-aminium +	0
N-methyl-2-methylpropan-1-aminium	0
N-methylmescalinium	0
N-methyltryptaminium	0
aculene A(1+)	0
aculene B(1+)	0
ciprofloxacin(1+)	0
dilevalol(1+) +	0
dizocilpine(1+) +	102
ent-tamsulosin(1+) +	0
fasudil(1+) +	0
heliamine(1+) +	0
herquline B(1+)	0
herquline C(1+)	0
mefuparib(1+) +	0
methamphetamine(1+) +	0
morpholinium	0
nirogacestat(2+) +	0
norreticuline(1+) +	0
norsalsolinol(1+)	0
perivine(1+)	0
piperidinium	0
pyrrolidinium ion +	1
secondary aliphatic ammonium ion +	0
solasodine 3-beta-D-glucoside(1+)	0
solasodine(1+)	0
spectinomycin(1+)	0
tamsulosin(1+) +	0
tomatidine(1+)	0
validoxylamine B(1+)	0

paths to the root