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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ilomastat
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Accession:CHEBI:137236 term browser browse the term
Definition:An N-acyl-amino acid obtained by formal condensation of the carboxy group of (2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoic acid with the amino group of N-methyl-L-tryptophanamide. A cell permeable broad-spectrum matrix metalloproteinase (MMP) inhibitor
Synonyms:exact_synonym: (2R)-N(4)-hydroxy-N(1)-[(2S)-3-(1H-indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl]-2-(2-methylpropyl)butanediamide
 related_synonym: CS 610;   Formula=C20H28N4O4;   GM 6001;   GM6001;   InChI=1S/C20H28N4O4/c1-12(2)8-13(10-18(25)24-28)19(26)23-17(20(27)21-3)9-14-11-22-16-7-5-4-6-15(14)16/h4-7,11-13,17,22,28H,8-10H2,1-3H3,(H,21,27)(H,23,26)(H,24,25)/t13-,17+/m1/s1;   InChIKey=NITYDPDXAAFEIT-DYVFJYSZSA-N;   SMILES=C(C(NO)=O)[C@H](C(N[C@H](C(NC)=O)CC=1C=2C(NC1)=CC=CC2)=O)CC(C)C;   galardin
 alt_id: CHEBI:42919
 xref: CAS:142880-36-2;   KEGG:D03793;   LINCS:LSM-3143
 xref_mesh: MESH:C119203
 xref: PDBeChem:GM6;   PMID:12410973;   PMID:14568001;   PMID:15350544;   PMID:16565079;   PMID:16712832;   PMID:18782669;   PMID:18790756;   PMID:18837084;   PMID:19545667;   PMID:20299089;   PMID:20818082;   PMID:21040999;   PMID:21146503;   PMID:22512086;   PMID:22903888;   PMID:23141517;   PMID:23870824;   PMID:24380772;   PMID:24589605;   PMID:25576979;   PMID:26171681;   PMID:26394037;   PMID:27038494;   PMID:27112177;   PMID:27296149;   PMID:27708133;   PMID:27743382;   PMID:28297575;   PMID:28298987;   PMID:28417261;   Reaxys:7982373;   Wikipedia:Ilomastat


show annotations for term's descendants           Sort by:
ilomastat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il13 interleukin 13 multiple interactions EXP ilomastat inhibits the reaction [Mustard Gas results in increased expression of IL13 protein] CTD PMID:18852015 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions EXP ilomastat affects the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MMP1 protein]; ilomastat inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MMP1 mRNA] CTD PMID:18837084 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP ilomastat affects the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TIMP1 mRNA]; ilomastat affects the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TIMP1 protein] CTD PMID:18837084 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      application 19695
        anti-inflammatory agent 16672
          ilomastat 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    main group molecular entity 19817
                      s-block molecular entity 19653
                        hydrogen molecular entity 19634
                          hydrides 19144
                            inorganic hydride 18161
                              pnictogen hydride 18151
                                nitrogen hydride 18064
                                  azane 17872
                                    ammonia 17871
                                      organic amino compound 17871
                                        amino acid 16060
                                          alpha-amino acid 13932
                                            L-alpha-amino acid 12141
                                              erythrose 4-phosphate/phosphoenolpyruvate family amino acid 2403
                                                L-tryptophan 21
                                                  L-tryptophan derivative 9
                                                    ilomastat 3
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