The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Organic heterohexacyclic compounds that are diterpenoid trilactones found in the ginkgo tree (also known as the maidenhair tree, Ginkgo biloba). They have a cage skeleton consisting of six 5-membered rings (a spiro[4.4]nonane carbobicyclic ring, three lactones and a tetrahydrofuran ring) which includes a tert-butyl substituent. The ginkolides vary only in the number and positions of their hydroxy substituents.
ginkgolide B results in increased expression of ABCB1 mRNA NR1I2 protein affects the reaction [ginkgolide B results in increased expression of ABCB1 mRNA]; sulforaphane inhibits the reaction [ginkgolide B results in increased expression of ABCB1 mRNA]
ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the activity of GPT protein]; ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of FTH1 protein]; ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of GPX4 protein]; ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of HMOX1 protein]; ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of NFE2L2 protein]; ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of TFRC protein]
ginkgolide B inhibits the reaction [APP protein results in increased abundance of Reactive Oxygen Species]; ginkgolide B inhibits the reaction [APP protein results in increased cleavage of and results in increased activity of CASP3 protein]; ginkgolide B inhibits the reaction [APP protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; ginkgolide B inhibits the reaction [APP protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; ginkgolide B inhibits the reaction [APP protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; ginkgolide B inhibits the reaction [APP protein results in increased phosphorylation of and results in increased activity of MAPK8 protein]
ginkgolide B inhibits the reaction [APP protein results in increased cleavage of and results in increased activity of CASP3 protein]; ginkgolide B inhibits the reaction [Doxorubicin results in increased cleavage of CASP3 protein]; ginkgolide B inhibits the reaction [Staurosporine results in increased cleavage of CASP3 protein] ginkgolide B inhibits the reaction [Ethanol results in increased activity of CASP3 protein]
[Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] affects the activity of CYP1A1 protein; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
ginkgolide B results in increased expression of and results in increased activity of CYP1A2 protein ginkgolide B results in increased expression of CYP1A2 mRNA
NR1I2 protein affects the reaction [ginkgolide B results in increased expression of CYP3A4 mRNA]; sulforaphane inhibits the reaction [ginkgolide B results in increased expression of CYP3A4 mRNA]
ginkgolide B inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in decreased expression of FTH1 protein] ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of FTH1 protein]
ginkgolide B inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in increased activity of GPT protein] ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the activity of GPT protein]
ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of GPX4 protein] ginkgolide B inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in decreased expression of GPX4 protein]
ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of HMOX1 protein] ginkgolide B inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in decreased expression of HMOX1 protein]
ginkgolide B inhibits the reaction [Cisplatin results in decreased expression of MIR214 mRNA]; MIR214 mRNA affects the reaction [ginkgolide B inhibits the reaction [Cisplatin results in increased expression of NOX4 mRNA]]; MIR214 mRNA affects the reaction [ginkgolide B inhibits the reaction [Cisplatin results in increased expression of SHC1 mRNA]]; MIR214 mRNA affects the reaction [ginkgolide B inhibits the reaction [Cisplatin results in increased expression of TRP53 mRNA]]
ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of NFE2L2 protein] ginkgolide B inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in decreased expression of and affects the localization of NFE2L2 protein]
ginkgolide B inhibits the reaction [Cisplatin promotes the reaction [TRP53 protein binds to NOX4 promoter]]; ginkgolide B inhibits the reaction [Cisplatin results in increased expression of NOX4 mRNA]; ginkgolide B inhibits the reaction [Cisplatin results in increased expression of NOX4 protein]; MIR214 mRNA affects the reaction [ginkgolide B inhibits the reaction [Cisplatin results in increased expression of NOX4 mRNA]]; TRP53 protein inhibits the reaction [ginkgolide B inhibits the reaction [Cisplatin promotes the reaction [TRP53 protein binds to NOX4 promoter]]]; TRP53 protein inhibits the reaction [ginkgolide B inhibits the reaction [Cisplatin results in increased expression of NOX4 mRNA]]
ginkgolide B results in increased activity of NR1I2 protein NR1I2 protein affects the reaction [ginkgolide B inhibits the reaction [TNF protein results in increased expression of SELE mRNA]]; NR1I2 protein affects the reaction [ginkgolide B inhibits the reaction [TNF protein results in increased expression of SELE protein]]; NR1I2 protein affects the reaction [ginkgolide B inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; NR1I2 protein affects the reaction [ginkgolide B inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]]; NR1I2 protein affects the reaction [ginkgolide B results in increased expression of ABCB1 mRNA]; NR1I2 protein affects the reaction [ginkgolide B results in increased expression of CYP3A4 mRNA] ginkgolide B affects the localization of NR1I2 protein
ginkgolide B inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; ginkgolide B inhibits the reaction [TNF protein results in increased expression of SELE protein]; NR1I2 protein affects the reaction [ginkgolide B inhibits the reaction [TNF protein results in increased expression of SELE mRNA]]; NR1I2 protein affects the reaction [ginkgolide B inhibits the reaction [TNF protein results in increased expression of SELE protein]]
ginkgolide B inhibits the reaction [Cisplatin promotes the reaction [TRP53 protein binds to SHC1 promoter]]; ginkgolide B inhibits the reaction [Cisplatin results in increased expression of SHC1 mRNA]; ginkgolide B inhibits the reaction [Cisplatin results in increased expression of SHC1 protein]; MIR214 mRNA affects the reaction [ginkgolide B inhibits the reaction [Cisplatin results in increased expression of SHC1 mRNA]]; TRP53 protein inhibits the reaction [ginkgolide B inhibits the reaction [Cisplatin promotes the reaction [TRP53 protein binds to SHC1 promoter]]]; TRP53 protein inhibits the reaction [ginkgolide B inhibits the reaction [Cisplatin results in increased expression of SHC1 mRNA]]
ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of TFRC protein] ginkgolide B inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in increased expression of TFRC protein]
ginkgolide B inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; ginkgolide B inhibits the reaction [TNF protein results in increased expression of SELE protein]; ginkgolide B inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; ginkgolide B inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; NR1I2 protein affects the reaction [ginkgolide B inhibits the reaction [TNF protein results in increased expression of SELE mRNA]]; NR1I2 protein affects the reaction [ginkgolide B inhibits the reaction [TNF protein results in increased expression of SELE protein]]; NR1I2 protein affects the reaction [ginkgolide B inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; NR1I2 protein affects the reaction [ginkgolide B inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]]
ginkgolide B inhibits the reaction [Cisplatin promotes the reaction [TRP53 protein binds to NOX4 promoter]]; ginkgolide B inhibits the reaction [Cisplatin promotes the reaction [TRP53 protein binds to SHC1 promoter]]; ginkgolide B inhibits the reaction [Cisplatin results in increased expression of TRP53 mRNA]; ginkgolide B inhibits the reaction [Cisplatin results in increased expression of TRP53 protein]; MIR214 mRNA affects the reaction [ginkgolide B inhibits the reaction [Cisplatin results in increased expression of TRP53 mRNA]]; TRP53 protein inhibits the reaction [ginkgolide B inhibits the reaction [Cisplatin promotes the reaction [TRP53 protein binds to NOX4 promoter]]]; TRP53 protein inhibits the reaction [ginkgolide B inhibits the reaction [Cisplatin promotes the reaction [TRP53 protein binds to SHC1 promoter]]]; TRP53 protein inhibits the reaction [ginkgolide B inhibits the reaction [Cisplatin results in increased expression of NOX4 mRNA]]; TRP53 protein inhibits the reaction [ginkgolide B inhibits the reaction [Cisplatin results in increased expression of SHC1 mRNA]]
ginkgolide B inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; ginkgolide B inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; NR1I2 protein affects the reaction [ginkgolide B inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; NR1I2 protein affects the reaction [ginkgolide B inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]]
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]; KT 5823 inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]; KT 5823 inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]
[Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] affects the activity of CYP1A1 protein; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
[Paraquat co-treated with ginkgolide C] results in increased expression of HMOX1 protein; ginkgolide C promotes the reaction [Paraquat results in increased expression of HMOX1 protein]
ginkgolide C results in increased localization of NFE2L2 protein ginkgolide C inhibits the reaction [Paraquat affects the localization of NFE2L2 protein]
ginkgolide C inhibits the reaction [Paraquat affects the localization of RELA protein]; ginkgolide C inhibits the reaction [Paraquat results in increased localization of RELA protein]
[Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] affects the activity of CYP1A1 protein; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
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