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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:eupatorin
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Accession:CHEBI:136666 term browser browse the term
Definition:A trimethoxyflavone that is 6-hydroxyluteolin in which the phenolic hydogens at positions 4', 6 and 7 have been replaced by methyl groups.
Synonyms:exact_synonym: 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-6,7-dimethoxy-4H-1-benzopyran-4-one
 related_synonym: 3',5-dihydroxy-4',6,7-trimethoxyflavone;   Eupatorine;   Formula=C18H16O7;   InChI=1S/C18H16O7/c1-22-12-5-4-9(6-10(12)19)13-7-11(20)16-14(25-13)8-15(23-2)18(24-3)17(16)21/h4-8,19,21H,1-3H3;   InChIKey=KLAOKWJLUQKWIF-UHFFFAOYSA-N;   SMILES=O1C=2C(=C(O)C(OC)=C(OC)C2)C(=O)C=C1C3=CC(O)=C(OC)C=C3
 xref: AGR:IND43745404;   AGR:IND605417569;   CAS:855-96-9;   Chemspider:87743;   KNApSAcK:C00003894;   LIPID_MAPS_instance:LMPK12111239
 xref_mesh: MESH:C103110
 xref: PMID:18454852;   PMID:19601638;   PMID:22227008;   PMID:22516932;   PMID:22698713;   PMID:22898066;   PMID:23839090;   PMID:24422962;   PMID:25390937;   PMID:25442272;   PMID:25598631;   PMID:26281557;   PMID:26322527;   PMID:26404257;   PMID:26649063;   PMID:26983579;   PMID:27187805;   PMID:27370961;   PMID:27470387;   PMID:27679866;   PMID:27695261;   PMID:27834876;   PMID:27991400;   PMID:28044092;   PMID:28347190;   PMID:29373904;   PMID:5847037;   PMID:905420;   Reaxys:1355109


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eupatorin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases response to substance
increases expression
decreases activity
increases metabolic processing		 ISO CYP1A1 protein results in increased susceptibility to eupatorin
eupatorin results in increased expression of CYP1A1 mRNA
eupatorin analog results in decreased activity of CYP1A1 protein
CYP1A1 protein results in increased metabolism of eupatorin analog		 CTD PMID:18454852 PMID:19601638 PMID:21482471 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases metabolic processing
decreases activity
increases expression		 ISO CYP1B1 protein results in increased metabolism of eupatorin analog
eupatorin results in decreased activity of CYP1B1 protein
eupatorin results in increased expression of CYP1B1 mRNA		 CTD PMID:19601638 PMID:21482471 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases activity ISO eupatorin results in decreased activity of CYP2C19 protein CTD PMID:21093571 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO eupatorin results in decreased activity of CYP2D6 protein CTD PMID:21276781 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO eupatorin results in decreased activity of CYP3A4 protein CTD PMID:21276781 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      application 19695
        anti-inflammatory agent 16672
          eupatorin 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            organic molecule 19706
                              organic cyclic compound 19495
                                organic heterocyclic compound 18874
                                  oxacycle 17906
                                    benzopyran 11972
                                      1-benzopyran 11726
                                        flavonoid 7226
                                          anthoxanthin 4585
                                            flavones 4585
                                              hydroxyflavone 4562
                                                3'-hydroxyflavonoid 307
                                                  luteolin 240
                                                    6-hydroxyluteolin 5
                                                      eupatorin 5
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