CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: S100 calcium-binding protein B inhibitor
Accession: CHEBI:136651
browse the term
Definition: Any inhibitor of S100 calcium-binding protein B.
Synonyms: related_synonym: S100 calcium-binding protein B inhibitors; S100B inhibitor; S100B inhibitors
xref: Wikipedia:S100B
G
Ar
androgen receptor
multiple interactions
ISO
Pentamidine binds to and results in decreased activity of AR protein
CTD
PMID:25752796
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
G
Asic5
acid sensing ion channel subunit family member 5
decreases activity
ISO
Pentamidine results in decreased activity of ASIC5 protein
CTD
PMID:21828194
NCBI chr 2:167,307,984...167,336,812
Ensembl chr 2:167,307,984...167,336,812
G
Asns
asparagine synthetase (glutamine-hydrolyzing)
increases expression
ISO
Pentamidine results in increased expression of ASNS mRNA
CTD
PMID:15342952
NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
G
Atm
ATM serine/threonine kinase
affects localization decreases activity
ISO
Pentamidine affects the localization of ATM protein modified form Pentamidine results in decreased activity of ATM protein
CTD
PMID:20144237
NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
G
Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
decreases activity
ISO
Pentamidine results in decreased activity of CYP1B1 protein
CTD
PMID:33814510
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
G
Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
decreases activity
ISO
Pentamidine results in decreased activity of CYP2C19 protein
CTD
PMID:11124226
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
G
Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
decreases activity
ISO
Pentamidine results in decreased activity of CYP2D6 protein
CTD
PMID:11124226
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
G
Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
decreases activity
ISO
Pentamidine results in decreased activity of CYP3A4 protein
CTD
PMID:11124226
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
G
Depp1
DEPP autophagy regulator 1
increases expression
ISO
Pentamidine results in increased expression of DEPP1 mRNA
CTD
PMID:15342952
NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542
G
Fabp1
fatty acid binding protein 1
decreases expression
ISO
Pentamidine results in decreased expression of FABP1 mRNA
CTD
PMID:15342952
NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
G
Fndc4
fibronectin type III domain containing 4
increases expression
ISO
Pentamidine results in increased expression of FNDC4 mRNA
CTD
PMID:15342952
NCBI chr 6:25,077,155...25,080,812
Ensembl chr 6:25,077,349...25,080,675
G
H2ax
H2A.X variant histone
affects localization
ISO
Pentamidine affects the localization of H2AX protein modified form
CTD
PMID:20144237
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 Ensembl chr 4:44,671,786...44,673,239
G
Hpn
hepsin
increases expression
ISO
Pentamidine results in increased expression of HPN mRNA
CTD
PMID:15342952
NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811
G
Ifng
interferon gamma
multiple interactions
ISO
[Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG protein [Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA
CTD
PMID:15588918 PMID:29594315
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
G
Ifngr1
interferon gamma receptor 1
increases expression
ISO
Pentamidine results in increased expression of IFNGR1 mRNA; Pentamidine results in increased expression of IFNGR1 protein
CTD
PMID:12803856
NCBI chr 1:14,333,167...14,351,799
Ensembl chr 1:14,333,187...14,351,785
G
Il10
interleukin 10
multiple interactions decreases expression
ISO
[Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL10 protein Pentamidine results in decreased expression of IL10 protein
CTD
PMID:15588918
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
G
Il1b
interleukin 1 beta
decreases expression
ISO
Pentamidine results in decreased expression of IL1B mRNA
CTD
PMID:29594315
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il2
interleukin 2
multiple interactions
ISO
[Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 protein [Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA
CTD
PMID:15588918 PMID:29594315
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
G
Il4
interleukin 4
multiple interactions
ISO
[Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL4 protein
CTD
PMID:15588918
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
G
Inhbe
inhibin subunit beta E
increases expression
ISO
Pentamidine results in increased expression of INHBE mRNA
CTD
PMID:15342952
NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172
G
Kat5
lysine acetyltransferase 5
multiple interactions decreases activity
ISO
Pentamidine inhibits the reaction [KAT5 protein results in increased acetylation of TP53 protein] Pentamidine results in decreased activity of KAT5 protein
CTD
PMID:20144237
NCBI chr 1:202,895,751...202,903,178
Ensembl chr 1:202,895,751...202,903,458
G
Kcnh2
potassium voltage-gated channel subfamily H member 2
multiple interactions decreases activity
ISO
Pentamidine affects the localization of and affects the activity of KCNH2 protein; Pentamidine affects the localization of and results in decreased activity of KCNH2 protein; Pentamidine inhibits the reaction [KCNH2 protein results in increased transport of Thallium] Pentamidine results in decreased activity of KCNH2 protein
CTD
PMID:15340016 PMID:15711590 PMID:21158687
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
G
Lss
lanosterol synthase
decreases expression
ISO
Pentamidine results in decreased expression of LSS mRNA
CTD
PMID:15342952
NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762
G
Mre11
MRE11 homolog, double strand break repair nuclease
decreases activity
ISO
Pentamidine results in decreased activity of MRE11 protein
CTD
PMID:20144237
NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279
G
Nbn
nibrin
affects localization
ISO
Pentamidine affects the localization of NBN protein
CTD
PMID:20144237
NCBI chr 5:29,459,574...29,494,152
Ensembl chr 5:29,459,457...29,494,150
G
Nr0b2
nuclear receptor subfamily 0, group B, member 2
increases expression
ISO
Pentamidine results in increased expression of NR0B2 mRNA
CTD
PMID:15342952
NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
G
Nr1h4
nuclear receptor subfamily 1, group H, member 4
increases activity
ISO
Pentamidine results in increased activity of NR1H4 protein
CTD
PMID:22414727
NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
G
Nupr1
nuclear protein 1, transcriptional regulator
increases expression
ISO
Pentamidine results in increased expression of NUPR1 mRNA
CTD
PMID:15342952
NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281
G
RT1-Bb
RT1 class II, locus Bb
affects expression
ISO
Pentamidine affects the expression of HLA-DQB1 mRNA
CTD
PMID:25811541
NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597
G
Serpina3n
serpin family A member 3N
increases expression
ISO
Pentamidine results in increased expression of SERPINA3 mRNA
CTD
PMID:15342952
NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433
G
Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Pentamidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
G
Slc2a3
solute carrier family 2 member 3
decreases expression
ISO
Pentamidine results in decreased expression of SLC2A3 mRNA
CTD
PMID:15342952
NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472
G
Tp53
tumor protein p53
multiple interactions
ISO
Pentamidine inhibits the reaction [KAT5 protein results in increased acetylation of TP53 protein]
CTD
PMID:20144237
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
G
Wipi1
WD repeat domain, phosphoinositide interacting 1
increases expression
ISO
Pentamidine results in increased expression of WIPI1 mRNA
CTD
PMID:15342952
NCBI chr10:94,542,946...94,580,174
Ensembl chr10:94,542,946...94,579,846
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all