Theaflavin 3,3'-digallate - Ontology Report - Rat Genome Database

Submit Data | Help | Video Tutorials | News | Publications | Download | REST API | Citing RGD | Contact

Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

{{ watchLinkText }}

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	Theaflavin 3,3'-digallate	go back to main search page
Accession:	CHEBI:136608	browse the term
Synonyms:	exact_synonym:	(3,4,5-Trihydroxy-6-oxo-6H-benzo[7]annulene-1,8-diyl)bis[(2R,3R)-5,7-dihydroxy-3,4-dihydro-2H-chromene-2,3-diyl] bis(3,4,5-trihydroxybenzoate)
	related_synonym:	Formula=C43H32O20; InChI=1S/C43H32O20/c44-17-7-23(46)21-12-33(62-42(58)15-3-25(48)36(54)26(49)4-15)40(60-31(21)9-17)14-1-19-20(11-30(53)39(57)35(19)38(56)29(52)2-14)41-34(13-22-24(47)8-18(45)10-32(22)61-41)63-43(59)16-5-27(50)37(55)28(51)6-16/h1-11,33-34,40-41,44-51,53-55,57H,12-13H2,(H,52,56)/t33-,34-,40-,41-/m1/s1; InChIKey=ZEASWHWETFMWCV-ISBUVJFSSA-N; SMILES=O1[C@@H]([C@H](OC(=O)C2=CC(O)=C(O)C(O)=C2)CC=3C1=CC(O)=CC3O)C=4C5=CC([C@H]6OC=7C(C[C@H]6OC(=O)C8=CC(O)=C(O)C(O)=C8)=C(O)C=C(O)C7)=CC(=O)C(O)=C5C(O)=C(O)C4
	xref:	Chemspider:410681
	xref_mesh:	MESH:C585473

show annotations for term's descendants Sort by:
Rat (514) Mouse (516) Human (550) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (514)

Theaflavin 3,3'-digallate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 2

affects expression

theaflavin-3,3'-digallate affects the expression of ABCC2 mRNA

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

acyl-CoA dehydrogenase medium chain

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [LEP gene mutant form affects the expression of ACADM mRNA]

NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147

G

aggrecan

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in decreased expression of ACAN mRNA]; theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in decreased expression of ACAN protein]

NCBI chr 1:132,981,582...133,044,416
Ensembl chr 1:132,981,582...133,043,627

G

1-aminocyclopropane-1-carboxylate synthase-like

affects expression

theaflavin-3,3'-digallate affects the expression of ACCSL mRNA

NCBI chr 3:79,826,464...79,841,163
Ensembl chr 3:79,826,464...79,841,163

G

angiotensin converting enzyme 2

affects binding

theaflavin-3,3'-digallate binds to ACE2 protein

NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977

G

acetylcholinesterase

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [Galactose results in increased activity of ACHE protein]

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

acyl-CoA thioesterase 6

affects expression

theaflavin-3,3'-digallate affects the expression of ACOT6 mRNA

NCBI chr 6:103,732,372...103,741,446
Ensembl chr 6:103,732,372...103,741,446

G

acrosin binding protein

affects expression

theaflavin-3,3'-digallate affects the expression of ACRBP mRNA

NCBI chr 4:157,851,149...157,864,211
Ensembl chr 4:157,841,841...157,864,213

G

actin alpha 2, smooth muscle

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [PDGFBB protein results in decreased expression of ACTA2 protein]

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

actin-like 6B

affects expression

theaflavin-3,3'-digallate affects the expression of ACTL6B mRNA

NCBI chr12:19,124,887...19,141,419
Ensembl chr12:19,124,916...19,141,376

G

ADAM metallopeptidase domain 30

affects expression

theaflavin-3,3'-digallate affects the expression of ADAM30 mRNA

NCBI chr 2:185,752,183...185,755,623
Ensembl chr 2:185,752,072...185,755,599

G

ADAM metallopeptidase domain 32

affects expression

theaflavin-3,3'-digallate affects the expression of ADAM32 mRNA

NCBI chr16:67,102,384...67,212,163
Ensembl chr16:67,102,320...67,212,161

G

ADAM metallopeptidase domain 33

affects expression

theaflavin-3,3'-digallate affects the expression of ADAM33 mRNA

NCBI chr 3:118,262,395...118,283,456
Ensembl chr 3:118,271,029...118,283,461

G

ADAM metallopeptidase with thrombospondin type 1 motif, 5

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in increased expression of ADAMTS5 mRNA]; theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in increased expression of ADAMTS5 protein]

NCBI chr11:25,000,627...25,047,205
Ensembl chr11:25,000,637...25,047,205

G

adducin 2

affects expression

theaflavin-3,3'-digallate affects the expression of ADD2 mRNA

NCBI chr 4:118,444,594...118,538,505
Ensembl chr 4:118,497,416...118,538,505

G

adhesion G protein-coupled receptor F2

affects expression

theaflavin-3,3'-digallate affects the expression of ADGRF2P mRNA

NCBI chr 9:18,238,389...18,248,745
Ensembl chr 9:18,219,714...18,269,038

G

adhesion G protein-coupled receptor G7

affects expression

theaflavin-3,3'-digallate affects the expression of ADGRG7 mRNA

NCBI chr11:43,808,101...43,877,539
Ensembl chr11:43,813,801...43,876,316

G

adiponectin, C1Q and collagen domain containing

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [Methylmercury Compounds results in increased secretion of ADIPOQ protein]

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

adrenoceptor alpha 2B

affects expression

theaflavin-3,3'-digallate affects the expression of ADRA2B mRNA

NCBI chr 3:114,585,174...114,589,220
Ensembl chr 3:114,585,169...114,589,355

G

androgen-dependent TFPI-regulating protein

affects expression

theaflavin-3,3'-digallate affects the expression of ADTRP mRNA

NCBI chr17:22,907,758...22,993,834
Ensembl chr17:22,930,740...22,993,826

G

angiotensinogen

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [AGT protein results in decreased abundance of Nitric Oxide]; theaflavin-3,3'-digallate inhibits the reaction [AGT protein results in decreased activity of CAT protein]; theaflavin-3,3'-digallate inhibits the reaction [AGT protein results in decreased phosphorylation of NFATC3 protein]; theaflavin-3,3'-digallate inhibits the reaction [AGT protein results in increased abundance of Reactive Oxygen Species]; theaflavin-3,3'-digallate inhibits the reaction [AGT protein results in increased expression of ANP mRNA]; theaflavin-3,3'-digallate inhibits the reaction [AGT protein results in increased expression of BNP mRNA]; theaflavin-3,3'-digallate inhibits the reaction [AGT protein results in increased expression of PPP3CA protein]

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

aryl hydrocarbon receptor

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [Tetrachlorodibenzodioxin binds to and affects the activity of AHR protein]

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

aryl hydrocarbon receptor-interacting protein-like 1

affects expression

theaflavin-3,3'-digallate affects the expression of AIPL1 mRNA

NCBI chr10:56,655,693...56,664,922
Ensembl chr10:56,655,693...56,664,922

G

AKT serine/threonine kinase 1

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in increased phosphorylation of AKT1 protein]; theaflavin-3,3'-digallate inhibits the reaction [PDGFBB protein results in increased phosphorylation of AKT1 protein]
theaflavin-3,3'-digallate inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]

PMID:12931129 PMID:35847580 PMID:35903325

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

allantoicase

affects expression

theaflavin-3,3'-digallate affects the expression of ALLC mRNA

NCBI chr 6:45,179,181...45,214,275
Ensembl chr 6:45,179,187...45,214,223

G

alkaline phosphatase, germ cell

affects expression

theaflavin-3,3'-digallate affects the expression of ALPPL2 mRNA

NCBI chr 9:87,748,721...87,761,500
Ensembl chr 9:87,753,648...87,757,836

G

anti-Mullerian hormone

increases expression

theaflavin-3,3'-digallate results in increased expression of AMH mRNA

NCBI chr 7:8,906,776...8,909,192
Ensembl chr 7:8,906,836...8,909,282

G

adenosine monophosphate deaminase 1

affects expression

theaflavin-3,3'-digallate affects the expression of AMPD1 mRNA

NCBI chr 2:190,598,707...190,619,938
Ensembl chr 2:190,598,700...190,619,938

G

archaelysin family metallopeptidase 1

affects expression

theaflavin-3,3'-digallate affects the expression of AMZ1 mRNA

NCBI chr12:13,886,518...13,924,275
Ensembl chr12:13,891,123...13,909,783

G

angiogenin

decreases secretion
multiple interactions

theaflavin-3,3'-digallate results in decreased secretion of ANG protein
[Methotrexate co-treated with theaflavin-3,3'-digallate] results in decreased secretion of ANG protein

NCBI chr15:24,312,711...24,323,361

G

ankyrin repeat and ubiquitin domain containing 1

affects expression

theaflavin-3,3'-digallate affects the expression of ANKUB1 mRNA

NCBI chr 2:141,857,623...141,894,624
Ensembl chr 2:141,856,573...141,894,339

G

apolipoprotein A4

affects expression

theaflavin-3,3'-digallate affects the expression of APOA4 mRNA

NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469

G

apolipoprotein L9a

affects expression

theaflavin-3,3'-digallate affects the expression of APOL4 mRNA

NCBI chr 7:109,140,871...109,149,799
Ensembl chr 7:109,140,871...109,147,649

G

activity-regulated cytoskeleton-associated protein

affects expression

theaflavin-3,3'-digallate affects the expression of ARC mRNA

NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378

G

amphiregulin

affects expression

theaflavin-3,3'-digallate affects the expression of AREG mRNA

NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535

G

ankyrin repeat and SOCS box containing 15

affects expression

theaflavin-3,3'-digallate affects the expression of ASB15 mRNA

NCBI chr 4:53,021,553...53,050,846
Ensembl chr 4:53,031,692...53,049,928

G

acid sensing ion channel subunit family member 4

affects expression

theaflavin-3,3'-digallate affects the expression of ASIC4 mRNA

NCBI chr 9:76,941,532...76,962,900
Ensembl chr 9:76,941,532...76,962,900

G

atonal bHLH transcription factor 1

affects expression

theaflavin-3,3'-digallate affects the expression of ATOH1 mRNA

NCBI chr 4:93,912,068...93,914,163
Ensembl chr 4:93,912,068...93,914,154

G

ATPase phospholipid transporting 10B

affects expression

theaflavin-3,3'-digallate affects the expression of ATP10B mRNA

NCBI chr10:27,495,207...27,751,313
Ensembl chr10:27,408,747...27,749,637

G

ATPase Na+/K+ transporting subunit alpha 4

affects expression

theaflavin-3,3'-digallate affects the expression of ATP1A4 mRNA

NCBI chr13:84,683,766...84,719,790
Ensembl chr13:84,683,768...84,719,687

G

ATPase Na+/K+ transporting family member beta 4

affects expression

theaflavin-3,3'-digallate affects the expression of ATP1B4 mRNA

NCBI chr X:117,087,284...117,108,023
Ensembl chr X:117,057,423...117,108,020

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1

affects expression

theaflavin-3,3'-digallate affects the expression of ATP2A1 mRNA

NCBI chr 1:181,026,606...181,044,859
Ensembl chr 1:181,026,608...181,044,838

G

ATPase plasma membrane Ca2+ transporting 2

affects expression

theaflavin-3,3'-digallate affects the expression of ATP2B2 mRNA

NCBI chr 4:146,894,602...147,208,060
Ensembl chr 4:146,896,332...147,140,665

G

advillin

affects expression

theaflavin-3,3'-digallate affects the expression of AVIL mRNA

NCBI chr 7:62,825,459...62,844,103
Ensembl chr 7:62,826,025...62,844,071

G

bile acid CoA:amino acid N-acyltransferase

affects expression

theaflavin-3,3'-digallate affects the expression of BAAT mRNA

NCBI chr 5:63,851,668...63,860,641
Ensembl chr 5:63,850,705...63,860,685

G

BCL2 associated X, apoptosis regulator

increases expression
decreases expression
multiple interactions

theaflavin-3,3'-digallate results in increased expression of BAX protein
theaflavin-3,3'-digallate results in decreased expression of BAX protein
[Methotrexate co-treated with theaflavin-3,3'-digallate] results in increased expression of BAX protein
theaflavin-3,3'-digallate results in decreased expression of BAX mRNA; theaflavin-3,3'-digallate results in decreased expression of BAX protein

PMID:30769778 PMID:32964953 PMID:34350509 PMID:34925699

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

increases expression
multiple interactions
decreases expression

theaflavin-3,3'-digallate results in increased expression of BCL2 mRNA; theaflavin-3,3'-digallate results in increased expression of BCL2 protein
[Methotrexate co-treated with theaflavin-3,3'-digallate] results in decreased expression of BCL2 protein
theaflavin-3,3'-digallate results in decreased expression of BCL2 protein

PMID:32964953 PMID:34350509

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

decreases expression

theaflavin-3,3'-digallate results in decreased expression of BCL2L1 protein

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

beclin 1

decreases expression
multiple interactions

theaflavin-3,3'-digallate results in decreased expression of BECN1 protein
[Methotrexate co-treated with theaflavin-3,3'-digallate] results in decreased expression of BECN1 protein

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

bone gamma-carboxyglutamate protein

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [TNF protein results in decreased expression of BGLAP protein]; theaflavin-3,3'-digallate results in increased expression of and results in increased secretion of BGLAP protein

NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495

G

bone morphogenetic protein 15

increases expression

theaflavin-3,3'-digallate results in increased expression of BMP15 mRNA

NCBI chr X:16,169,123...16,174,187
Ensembl chr X:16,169,123...16,174,187

G

basonuclin zinc finger protein 1

affects expression

theaflavin-3,3'-digallate affects the expression of BNC1 mRNA

NCBI chr 1:135,917,676...135,943,333
Ensembl chr 1:135,917,687...135,943,333

G

BCL2 interacting protein like

affects expression

theaflavin-3,3'-digallate affects the expression of BNIPL mRNA

NCBI chr 2:182,818,593...182,830,421
Ensembl chr 2:182,818,595...182,828,588

G

BOP1 ribosomal biogenesis factor

affects expression

theaflavin-3,3'-digallate affects the expression of BOP1 mRNA

NCBI chr 7:108,172,062...108,195,875
Ensembl chr 7:108,172,066...108,195,931

G

B and T lymphocyte associated

affects expression

theaflavin-3,3'-digallate affects the expression of BTLA mRNA

NCBI chr11:55,563,683...55,588,187
Ensembl chr11:55,564,899...55,587,181

G

butyrophilin, subfamily 1, member A1

affects expression

theaflavin-3,3'-digallate affects the expression of BTN1A1 mRNA

NCBI chr17:41,653,499...41,664,246
Ensembl chr17:41,654,249...41,664,272

G

bystin-like

affects expression

theaflavin-3,3'-digallate affects the expression of BYSL mRNA

NCBI chr 9:13,382,806...13,392,557
Ensembl chr 9:13,382,557...13,394,339

G

similar to human chromosome 1 open reading frame 116

affects expression

theaflavin-3,3'-digallate affects the expression of C1ORF116 mRNA

NCBI chr13:42,187,442...42,201,432
Ensembl chr13:42,188,609...42,201,426

G

similar to human chromosome 4 open reading frame 19

affects expression

theaflavin-3,3'-digallate affects the expression of C4ORF19 mRNA

NCBI chr14:44,387,386...44,478,344
Ensembl chr14:44,387,393...44,478,041

G

C1q and TNF related 2

affects expression

theaflavin-3,3'-digallate affects the expression of C1QTNF2 mRNA

NCBI chr10:27,941,948...27,958,926
Ensembl chr10:27,941,948...27,959,185

G

similar to human chromosome 3 open reading frame 20

affects expression

theaflavin-3,3'-digallate affects the expression of C3ORF20 mRNA

NCBI chr 4:124,422,033...124,470,657
Ensembl chr 4:124,432,193...124,469,254

G

complement C5a receptor 2

affects expression

theaflavin-3,3'-digallate affects the expression of C5AR2 mRNA

NCBI chr 1:76,930,381...76,945,432
Ensembl chr 1:76,930,383...76,959,517

G

similar to human chromosome 9 open reading frame 152

affects expression

theaflavin-3,3'-digallate affects the expression of C9ORF152 mRNA

NCBI chr 5:72,660,573...72,667,941
Ensembl chr 5:72,660,573...72,668,379

G

similar to human chromosome 12 open reading frame 50

affects expression

theaflavin-3,3'-digallate affects the expression of C12ORF50 mRNA

NCBI chr 7:35,406,147...35,443,324
Ensembl chr 7:35,411,555...35,443,320

G

complement C9

affects expression

theaflavin-3,3'-digallate affects the expression of C9 mRNA

NCBI chr 2:55,573,094...55,621,345
Ensembl chr 2:55,572,992...55,621,338

G

calpain 11

affects expression

theaflavin-3,3'-digallate affects the expression of CAPN11 mRNA

NCBI chr 9:15,344,059...15,365,604
Ensembl chr 9:15,344,089...15,365,601

G

caspase 3

decreases expression
increases activity
multiple interactions

theaflavin-3,3'-digallate results in decreased expression of CASP3 protein
theaflavin-3,3'-digallate results in decreased expression of CASP3 mRNA; theaflavin-3,3'-digallate results in decreased expression of CASP3 protein
theaflavin-3,3'-digallate results in increased activity of CASP3 protein
[Methotrexate co-treated with theaflavin-3,3'-digallate] results in increased expression of and results in increased cleavage of and results in increased activity of CASP3 protein; theaflavin-3,3'-digallate results in increased expression of and results in increased cleavage of and results in increased activity of CASP3 protein

PMID:30769778 PMID:32964953 PMID:34350509 PMID:34925699

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

increases activity

theaflavin-3,3'-digallate results in increased activity of CASP8 protein

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions
increases activity

[Methotrexate co-treated with theaflavin-3,3'-digallate] results in increased expression of and results in increased cleavage of and results in increased activity of CASP9 protein; theaflavin-3,3'-digallate results in increased expression of and results in increased cleavage of and results in increased activity of CASP9 protein
theaflavin-3,3'-digallate results in increased activity of CASP9 protein

PMID:30769778 PMID:34350509

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

Cas scaffold protein family member 4

affects expression

theaflavin-3,3'-digallate affects the expression of CASS4 mRNA

NCBI chr 3:161,162,520...161,202,523
Ensembl chr 3:161,163,436...161,202,186

G

catalase

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [TNFSF11 protein results in decreased expression of CAT mRNA]
theaflavin-3,3'-digallate inhibits the reaction [AGT protein results in decreased activity of CAT protein]

PMID:32694992 PMID:35406003

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

coiled-coil and C2 domain containing 2B

affects expression

theaflavin-3,3'-digallate affects the expression of CC2D2B mRNA

NCBI chr 1:239,561,506...239,655,771
Ensembl chr 1:239,561,987...239,682,416

G

coiled-coil domain containing 17

affects expression

theaflavin-3,3'-digallate affects the expression of CCDC17 mRNA

NCBI chr 5:130,051,158...130,056,676
Ensembl chr 5:130,045,938...130,056,673

G

coiled-coil domain containing 62

affects expression

theaflavin-3,3'-digallate affects the expression of CCDC62 mRNA

NCBI chr12:32,623,170...32,659,912
Ensembl chr12:32,623,170...32,660,017

G

coiled-coil domain containing 65

affects expression

theaflavin-3,3'-digallate affects the expression of CCDC65 mRNA

NCBI chr 7:129,857,118...129,870,803
Ensembl chr 7:129,857,247...129,870,803

G

coiled-coil domain containing 70

affects expression

theaflavin-3,3'-digallate affects the expression of CCDC70 mRNA

NCBI chr16:70,037,309...70,042,401
Ensembl chr16:70,037,309...70,042,339

G

C-C motif chemokine ligand 4

affects expression

theaflavin-3,3'-digallate affects the expression of CCL4 mRNA

NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231

G

cyclin D1

decreases expression
multiple interactions

theaflavin-3,3'-digallate results in decreased expression of CCND1 protein
CDKN1B promotes the reaction [theaflavin-3,3'-digallate results in decreased expression of CCND1 protein]

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

C-C motif chemokine receptor 1

affects expression

theaflavin-3,3'-digallate affects the expression of CCR1 mRNA

NCBI chr 8:123,556,286...123,561,841

G

C-C motif chemokine receptor 6

affects expression

theaflavin-3,3'-digallate affects the expression of CCR6 mRNA

NCBI chr 1:52,474,477...52,508,301
Ensembl chr 1:52,474,168...52,498,603

G

Cd300e molecule

affects expression

theaflavin-3,3'-digallate affects the expression of CD300E mRNA

NCBI chr10:100,289,729...100,309,996
Ensembl chr10:100,291,437...100,299,311

G

CD33 molecule

affects expression

theaflavin-3,3'-digallate affects the expression of CD33 mRNA

NCBI chr 1:93,935,418...93,940,452
Ensembl chr 1:93,930,971...93,950,149

G

CD3 gamma subunit of T-cell receptor complex

affects expression

theaflavin-3,3'-digallate affects the expression of CD3G mRNA

NCBI chr 8:45,280,797...45,287,271
Ensembl chr 8:45,281,204...45,287,147

G

CD40 molecule

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [TNFSF11 protein results in increased expression of CD40 mRNA]

NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534

G

Cd69 molecule

affects expression

theaflavin-3,3'-digallate affects the expression of CD69 mRNA

NCBI chr 4:162,725,446...162,733,364
Ensembl chr 4:162,725,446...162,733,542

G

CDC42 effector protein 1

affects expression

theaflavin-3,3'-digallate affects the expression of CDC42EP1 mRNA

NCBI chr 7:110,395,287...110,403,203
Ensembl chr 7:110,395,332...110,403,200

G

cyclin-dependent kinase 4

decreases expression
multiple interactions

theaflavin-3,3'-digallate results in decreased expression of CDK4 protein
CDKN1B promotes the reaction [theaflavin-3,3'-digallate results in decreased expression of CDK4 protein]

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase 5 regulatory subunit 1

affects expression

theaflavin-3,3'-digallate affects the expression of CDK5R1 mRNA

NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456

G

cyclin-dependent kinase inhibitor 1B

multiple interactions
increases expression

CDKN1B promotes the reaction [theaflavin-3,3'-digallate results in decreased expression of and results in decreased phosphorylation of RB1 protein]; CDKN1B promotes the reaction [theaflavin-3,3'-digallate results in decreased expression of CCND1 protein]; CDKN1B promotes the reaction [theaflavin-3,3'-digallate results in decreased expression of CDK4 protein]
theaflavin-3,3'-digallate results in increased expression of CDKN1B protein

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

caudal type homeo box 2

affects expression

theaflavin-3,3'-digallate affects the expression of CDX2 mRNA

NCBI chr12:7,726,798...7,733,142
Ensembl chr12:7,726,798...7,733,142

G

CEA cell adhesion molecule 4

affects expression

theaflavin-3,3'-digallate affects the expression of CEACAM4 mRNA

NCBI chr 1:80,376,667...80,382,943
Ensembl chr 1:80,376,648...80,382,915

G

CCAAT/enhancer binding protein alpha

affects expression

theaflavin-3,3'-digallate affects the expression of CEBPA mRNA

NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412

G

cilia and flagella associated protein 141

affects expression

theaflavin-3,3'-digallate affects the expression of CFAP141 mRNA

NCBI chr 2:175,507,628...175,510,662
Ensembl chr 2:175,507,628...175,510,662

G

cilia and flagella associated protein 161

affects expression

theaflavin-3,3'-digallate affects the expression of CFAP161 mRNA

NCBI chr 1:137,743,783...137,768,685
Ensembl chr 1:137,743,784...137,768,730

G

cilia and flagella associated protein 206

affects expression

theaflavin-3,3'-digallate affects the expression of CFAP206 mRNA

NCBI chr 5:49,254,399...49,299,145
Ensembl chr 5:49,254,408...49,299,090

G

cilia and flagella associated protein 276

affects expression

theaflavin-3,3'-digallate affects the expression of CFAP276 mRNA

NCBI chr 2:196,166,009...196,177,919
Ensembl chr 2:196,166,009...196,177,919

G

ChaC glutathione-specific gamma-glutamylcyclotransferase 1

affects expression

theaflavin-3,3'-digallate affects the expression of CHAC1 mRNA

NCBI chr 3:106,342,302...106,345,526
Ensembl chr 3:106,342,302...106,345,526

G

chromodomain helicase DNA binding protein 5

affects expression

theaflavin-3,3'-digallate affects the expression of CHD5 mRNA

NCBI chr 5:162,848,273...162,898,997
Ensembl chr 5:162,848,394...162,896,291

G

checkpoint kinase 2

increases phosphorylation

theaflavin-3,3'-digallate results in increased phosphorylation of CHEK2 protein

NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286

G

cholinergic receptor, muscarinic 5

affects expression

theaflavin-3,3'-digallate affects the expression of CHRM5 mRNA

NCBI chr 3:99,284,846...99,337,252
Ensembl chr 3:99,284,846...99,337,252

G

cholinergic receptor nicotinic alpha 3 subunit

affects expression

theaflavin-3,3'-digallate affects the expression of CHRNA3 mRNA

NCBI chr 8:55,401,668...55,415,165
Ensembl chr 8:55,401,702...55,415,165

G

cholinergic receptor nicotinic alpha 4 subunit

affects expression

theaflavin-3,3'-digallate affects the expression of CHRNA4 mRNA

NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957

G

chloride voltage-gated channel 1

affects expression

theaflavin-3,3'-digallate affects the expression of CLCN1 mRNA

NCBI chr 4:71,171,949...71,201,483
Ensembl chr 4:71,172,547...71,199,984

G

claudin 19

affects expression

theaflavin-3,3'-digallate affects the expression of CLDN19 mRNA

NCBI chr 5:132,862,939...132,870,364
Ensembl chr 5:132,863,267...132,868,227

G

C-type lectin domain family 4, member A1

affects expression

theaflavin-3,3'-digallate affects the expression of ZNF705A mRNA

NCBI chr 4:156,173,894...156,186,009
Ensembl chr 4:156,173,894...156,186,008

G

C-type lectin domain containing 5A

affects expression

theaflavin-3,3'-digallate affects the expression of CLEC5A mRNA

NCBI chr 4:69,407,125...69,416,872
Ensembl chr 4:69,407,835...69,416,859

G

C-type lectin domain containing 7A

affects expression

theaflavin-3,3'-digallate affects the expression of CLEC7A mRNA

NCBI chr 4:162,902,731...162,913,931
Ensembl chr 4:162,902,732...162,913,897

G

CKLF-like MARVEL transmembrane domain containing 2B

affects expression

theaflavin-3,3'-digallate affects the expression of CMTM2 mRNA

NCBI chr19:640,838...651,872
Ensembl chr19:640,824...651,939

G

cyclic nucleotide binding domain containing 2

affects expression

theaflavin-3,3'-digallate affects the expression of CNBD2 mRNA

NCBI chr 3:144,819,166...144,884,825
Ensembl chr 3:144,819,195...144,901,583

G

carnosine dipeptidase 1

affects expression

theaflavin-3,3'-digallate affects the expression of CNDP1 mRNA

NCBI chr18:77,984,886...78,030,837
Ensembl chr18:77,984,907...78,007,765

G

cannabinoid receptor 1

affects expression

theaflavin-3,3'-digallate affects the expression of CNR1 mRNA

NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099

G

collagen type XI alpha 2 chain

affects expression

theaflavin-3,3'-digallate affects the expression of COL11A2 mRNA

NCBI chr20:4,786,932...4,816,598
Ensembl chr20:4,786,929...4,815,985

G

collagen type II alpha 1 chain

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in decreased expression of COL2A1 mRNA]; theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in decreased expression of COL2A1 protein]

NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546

G

complexin 3

affects expression

theaflavin-3,3'-digallate affects the expression of CPLX3 mRNA

NCBI chr 8:58,003,535...58,010,297
Ensembl chr 8:58,003,535...58,010,297

G

complement C3d receptor 2

affects expression

theaflavin-3,3'-digallate affects the expression of CR2 mRNA

NCBI chr13:106,678,579...106,716,595
Ensembl chr13:106,685,413...106,716,235

G

crystallin, beta B2

affects expression

theaflavin-3,3'-digallate affects the expression of CRYBB2 mRNA

NCBI chr12:43,569,747...43,579,671
Ensembl chr12:43,569,747...43,579,671

G

catenin beta 1

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [TNF protein results in decreased expression of CTNNB1 protein]

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cathepsin K

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]

NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550

G

cathepsin L

decreases expression

theaflavin-3,3'-digallate results in decreased expression of CTSL protein

NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [LEP gene mutant form affects the expression of CYP1A2 mRNA]

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 26, subfamily a, polypeptide 1

affects expression

theaflavin-3,3'-digallate affects the expression of CYP26A1 mRNA

NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204

G

cytochrome P450, family 2, subfamily b, polypeptide 3

affects expression

theaflavin-3,3'-digallate affects the expression of CYP2B6 mRNA

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 4, subfamily b, polypeptide 1

affects expression

theaflavin-3,3'-digallate affects the expression of CYP4B1 mRNA

NCBI chr 5:129,139,019...129,176,860
Ensembl chr 5:129,139,038...129,156,348

G

cytochrome P450, family 4, subfamily f, polypeptide 1

affects expression
multiple interactions

theaflavin-3,3'-digallate affects the expression of CYP4F12 mRNA
theaflavin-3,3'-digallate inhibits the reaction [LEP gene mutant form affects the expression of CYP4F14 mRNA]

PMID:34925699 PMID:36105184

NCBI chr 7:12,010,850...12,022,497
Ensembl chr 7:12,010,852...12,022,046

G

cytochrome P450 family 7 subfamily A member 1

affects expression

theaflavin-3,3'-digallate affects the expression of CYP7A1 mRNA

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

DDB1 and CUL4 associated factor 12-like 1

affects expression

theaflavin-3,3'-digallate affects the expression of DCAF12L1 mRNA

NCBI chr X:123,695,286...123,698,905
Ensembl chr X:123,695,286...123,698,905

G

DNA-damage inducible transcript 3

affects expression
multiple interactions

theaflavin-3,3'-digallate affects the expression of DDIT3 mRNA
[Methotrexate co-treated with theaflavin-3,3'-digallate] results in increased expression of DDIT3 protein

PMID:34350509 PMID:34925699

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

diacylglycerol kinase, beta

affects expression

theaflavin-3,3'-digallate affects the expression of DGKB mRNA

NCBI chr 6:54,640,948...55,397,210
Ensembl chr 6:54,641,614...55,397,043

G

7-dehydrocholesterol reductase

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [LEP gene mutant form affects the expression of DHCR7 mRNA]

NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055

G

dehydrogenase/reductase 9

affects expression

theaflavin-3,3'-digallate affects the expression of DHRS9 mRNA

NCBI chr 3:54,147,834...54,170,052
Ensembl chr 3:54,147,803...54,220,241

G

dickkopf WNT signaling pathway inhibitor 4

affects expression

theaflavin-3,3'-digallate affects the expression of DKK4 mRNA

NCBI chr16:69,403,215...69,406,580
Ensembl chr16:69,402,989...69,406,580

G

distal-less homeobox 1

affects expression

theaflavin-3,3'-digallate affects the expression of DLX1 mRNA

NCBI chr 3:56,356,190...56,360,780
Ensembl chr 3:56,356,190...56,360,780

G

dynein, axonemal, assembly factor 1

affects expression

theaflavin-3,3'-digallate affects the expression of DNAAF1 mRNA

NCBI chr19:47,624,534...47,652,314
Ensembl chr19:47,624,181...47,652,313

G

dynein, axonemal, heavy chain 11

affects expression

theaflavin-3,3'-digallate affects the expression of DNAH11 mRNA

NCBI chr 6:138,839,175...139,155,554
Ensembl chr 6:138,839,177...139,155,536

G

dynein, axonemal, heavy chain 12

affects expression

theaflavin-3,3'-digallate affects the expression of DNAH12 mRNA

NCBI chr16:1,936,354...2,092,663
Ensembl chr16:1,937,817...2,092,664

G

deoxyribonuclease 2 beta

affects expression

theaflavin-3,3'-digallate affects the expression of DNASE2B mRNA

NCBI chr 2:235,470,915...235,515,211
Ensembl chr 2:235,470,919...235,486,295

G

docking protein 2

affects expression

theaflavin-3,3'-digallate affects the expression of DOK2 mRNA

NCBI chr15:45,826,984...45,841,409
Ensembl chr15:45,827,398...45,841,402

G

developmental pluripotency-associated 3

affects expression

theaflavin-3,3'-digallate affects the expression of DPPA3 mRNA

NCBI chr 4:155,851,461...155,854,845
Ensembl chr 4:155,815,296...155,854,861
Ensembl chr 5:155,815,296...155,854,861

G

developmental pluripotency associated 5

affects expression

theaflavin-3,3'-digallate affects the expression of DPPA5 mRNA

NCBI chr 8:79,215,341...79,217,282
Ensembl chr 8:79,215,362...79,216,570
Ensembl chr 7:79,215,362...79,216,570
Ensembl chr 1:79,215,362...79,216,570
Ensembl chr 3:79,215,362...79,216,570

G

dynein regulatory complex subunit 7

affects expression

theaflavin-3,3'-digallate affects the expression of DRC7 mRNA

NCBI chr19:9,943,452...9,961,266
Ensembl chr19:9,943,456...9,961,163

G

DS cell adhesion molecule-like 1

affects expression

theaflavin-3,3'-digallate affects the expression of DSCAML1 mRNA

NCBI chr 8:45,740,298...46,057,322
Ensembl chr 8:45,740,298...46,057,320

G

endogenous Bornavirus like nucleoprotein 1

affects expression

theaflavin-3,3'-digallate affects the expression of EBLN1 mRNA

NCBI chr10:78,938,645...78,940,651

G

EBP, cholestenol delta-isomerase

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [LEP gene mutant form affects the expression of EBP mRNA]

NCBI chr X:14,299,427...14,305,826
Ensembl chr X:14,299,448...14,305,826

G

endothelin 1

affects expression

theaflavin-3,3'-digallate affects the expression of EDN1 mRNA

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

ephrin B1

affects expression

theaflavin-3,3'-digallate affects the expression of EFNB1 mRNA

NCBI chr X:64,257,351...64,270,158
Ensembl chr X:64,257,351...64,270,157

G

epidermal growth factor

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [EGF protein results in increased activity of SP1 protein]; theaflavin-3,3'-digallate inhibits the reaction [EGF protein results in increased expression of FAS mRNA]; theaflavin-3,3'-digallate inhibits the reaction [EGF protein results in increased expression of FAS protein]; theaflavin-3,3'-digallate inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]
theaflavin-3,3'-digallate inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of EGFR protein]; theaflavin-3,3'-digallate inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; theaflavin-3,3'-digallate inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]

PMID:12931129 PMID:16353237

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

epidermal growth factor receptor

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of EGFR protein]
theaflavin-3,3'-digallate results in increased ubiquitination of and results in increased degradation of and results in decreased expression of EGFR protein

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

ELOVL fatty acid elongase 1

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [LEP gene mutant form affects the expression of ELOVL1 mRNA]

NCBI chr 5:131,961,478...131,965,961
Ensembl chr 5:131,961,322...131,965,958

G

Eph receptor A8

affects expression

theaflavin-3,3'-digallate affects the expression of EPHA8 mRNA

NCBI chr 5:149,166,107...149,193,515
Ensembl chr 5:149,166,697...149,193,399

G

ermin

affects expression

theaflavin-3,3'-digallate affects the expression of ERMN mRNA

NCBI chr 3:42,628,160...42,633,816
Ensembl chr 3:42,626,309...42,633,744

G

endoplasmic reticulum to nucleus signaling 1

multiple interactions
decreases expression

[Methotrexate co-treated with theaflavin-3,3'-digallate] results in decreased expression of ERN1 mRNA
theaflavin-3,3'-digallate results in decreased expression of ERN1 mRNA

NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029

G

ERBB receptor feedback inhibitor 1

affects expression

theaflavin-3,3'-digallate affects the expression of ERRFI1 mRNA

NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282

G

envoplakin

affects expression

theaflavin-3,3'-digallate affects the expression of EVPL mRNA

NCBI chr10:101,458,227...101,474,778
Ensembl chr10:101,458,216...101,474,763

G

EZH inhibitory protein

affects expression

theaflavin-3,3'-digallate affects the expression of EZHIP mRNA

NCBI chr X:16,368,582...16,371,648
Ensembl chr X:16,368,962...16,372,256

G

coagulation factor XI

affects expression

theaflavin-3,3'-digallate affects the expression of F11 mRNA

NCBI chr16:46,987,988...47,009,015
Ensembl chr16:46,986,107...47,008,437

G

coagulation factor XIII B chain

affects expression

theaflavin-3,3'-digallate affects the expression of F13B mRNA

NCBI chr13:51,130,908...51,156,383
Ensembl chr13:51,130,920...51,156,381

G

coagulation factor II, thrombin

affects expression

theaflavin-3,3'-digallate affects the expression of F2 mRNA

NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486

G

F2R like thrombin or trypsin receptor 3

affects expression

theaflavin-3,3'-digallate affects the expression of F2RL3 mRNA

NCBI chr16:17,117,441...17,119,434
Ensembl chr16:17,117,441...17,119,472

G

coagulation factor III, tissue factor

affects expression

theaflavin-3,3'-digallate affects the expression of F3 mRNA

NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668

G

fatty acid binding protein 12

affects expression

theaflavin-3,3'-digallate affects the expression of FABP12 mRNA

NCBI chr 2:91,539,568...91,554,999
Ensembl chr 2:91,500,539...91,554,996

G

fatty acid binding protein 4

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [LEP gene mutant form affects the expression of FABP4 mRNA]

NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578

G

fatty acid desaturase 1

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [LEP gene mutant form affects the expression of FADS1 mRNA]

NCBI chr 1:206,827,724...206,842,734
Ensembl chr 1:206,827,765...206,842,734

G

family with sequence similarity 177 member B

affects expression

theaflavin-3,3'-digallate affects the expression of FAM177B mRNA

NCBI chr13:94,904,128...94,909,688

G

family with sequence similarity 180, member A

affects expression

theaflavin-3,3'-digallate affects the expression of FAM180A mRNA

NCBI chr 4:63,992,867...64,008,047
Ensembl chr 4:63,992,867...64,008,047

G

family with sequence similarity 83, member C

affects expression

theaflavin-3,3'-digallate affects the expression of FAM83C mRNA

NCBI chr 3:144,333,736...144,339,758
Ensembl chr 3:144,332,982...144,339,802

G

Fas cell surface death receptor

multiple interactions
increases expression

theaflavin-3,3'-digallate inhibits the reaction [EGF protein results in increased expression of FAS mRNA]; theaflavin-3,3'-digallate inhibits the reaction [EGF protein results in increased expression of FAS protein]
theaflavin-3,3'-digallate results in increased expression of FAS protein

PMID:12931129 PMID:30769778

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

Fas ligand

affects expression

theaflavin-3,3'-digallate affects the expression of FASLG mRNA

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

Fc alpha and mu receptor

affects expression

theaflavin-3,3'-digallate affects the expression of FCAMR mRNA

NCBI chr13:42,273,891...42,288,002
Ensembl chr13:42,273,628...42,287,113

G

Fc receptor-like 5

affects expression

theaflavin-3,3'-digallate affects the expression of FCRL5 mRNA

NCBI chr 2:172,881,763...172,912,912
Ensembl chr 2:172,881,448...172,913,148

G

Fc receptor-like 6

affects expression

theaflavin-3,3'-digallate affects the expression of FCRL6 mRNA

NCBI chr13:85,062,709...85,072,308
Ensembl chr13:85,066,694...85,072,600

G

farnesyl diphosphate farnesyl transferase 1

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [LEP gene mutant form affects the expression of FDFT1 mRNA]

NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287

G

FYVE, RhoGEF and PH domain containing 2

affects expression

theaflavin-3,3'-digallate affects the expression of FGD2 mRNA

NCBI chr20:7,424,795...7,441,603
Ensembl chr20:7,424,790...7,441,603

G

fibroblast growth factor 17

affects expression

theaflavin-3,3'-digallate affects the expression of FGF17 mRNA

NCBI chr15:45,711,498...45,717,622
Ensembl chr15:45,711,998...45,717,063

G

fibroblast growth factor 18

affects expression

theaflavin-3,3'-digallate affects the expression of FGF18 mRNA

NCBI chr10:17,706,011...17,737,702
Ensembl chr10:17,706,174...17,736,818

G

Fli-1 proto-oncogene, ETS transcription factor

affects expression

theaflavin-3,3'-digallate affects the expression of FLI1 mRNA

NCBI chr 8:30,831,422...30,950,468
Ensembl chr 8:30,832,753...30,950,433

G

fibronectin type III domain containing 7

affects expression

theaflavin-3,3'-digallate affects the expression of FNDC7 mRNA

NCBI chr 2:196,501,313...196,537,816
Ensembl chr 2:196,502,460...196,537,694

G

forkhead box D3

affects expression

theaflavin-3,3'-digallate affects the expression of FOXD3 mRNA

NCBI chr 5:114,335,084...114,337,450
Ensembl chr 5:114,335,408...114,336,817

G

forkhead box D4

affects expression

theaflavin-3,3'-digallate affects the expression of FOXD4 mRNA

NCBI chr 1:222,557,494...222,559,189
Ensembl chr 1:222,557,360...222,559,159

G

forkhead box E3

affects expression

theaflavin-3,3'-digallate affects the expression of FOXE3 mRNA

NCBI chr 5:128,444,912...128,446,494
Ensembl chr 5:128,445,594...128,446,454

G

forkhead box G1

affects expression

theaflavin-3,3'-digallate affects the expression of FOXG1 mRNA

NCBI chr 6:66,674,797...66,677,611
Ensembl chr 6:66,666,587...66,678,607

G

forkhead box L1

affects expression

theaflavin-3,3'-digallate affects the expression of FOXL1 mRNA

NCBI chr19:49,197,269...49,200,682
Ensembl chr19:49,197,400...49,198,425

G

forkhead box Q1

affects expression

theaflavin-3,3'-digallate affects the expression of FOXQ1 mRNA

NCBI chr17:32,912,744...32,915,377
Ensembl chr17:32,912,744...32,915,377
Ensembl chr17:32,912,744...32,915,377

G

FERM domain containing 7

affects expression

theaflavin-3,3'-digallate affects the expression of FRMD7 mRNA

NCBI chr X:130,375,925...130,423,836
Ensembl chr X:130,377,227...130,423,771

G

frizzled-related protein

affects expression

theaflavin-3,3'-digallate affects the expression of FRZB mRNA

NCBI chr 3:65,332,274...65,365,208
Ensembl chr 3:65,332,277...65,365,208

G

fascin actin-bundling protein 3

affects expression

theaflavin-3,3'-digallate affects the expression of FSCN3 mRNA

NCBI chr 4:57,042,797...57,052,224
Ensembl chr 4:57,042,797...57,052,404

G

gamma-aminobutyric acid type A receptor subunit rho 1

affects expression

theaflavin-3,3'-digallate affects the expression of GABRR1 mRNA

NCBI chr 5:47,524,151...47,561,228
Ensembl chr 5:47,524,151...47,561,228

G

polypeptide N-acetylgalactosaminyltransferase 14

affects expression

theaflavin-3,3'-digallate affects the expression of GALNT14 mRNA

NCBI chr 6:21,756,039...21,977,533
Ensembl chr 6:21,755,195...21,972,192

G

golgi associated RAB2 interactor 1A

affects expression

theaflavin-3,3'-digallate affects the expression of GARIN1A mRNA

NCBI chr 4:57,880,019...57,890,824
Ensembl chr 4:57,880,019...57,890,820

G

golgi associated RAB2 interactor family member 4

affects expression

theaflavin-3,3'-digallate affects the expression of GARIN4 mRNA

NCBI chr13:102,742,988...102,745,168
Ensembl chr13:102,742,988...102,745,168

G

growth differentiation factor 9

affects expression
increases expression

theaflavin-3,3'-digallate affects the expression of GDF9 mRNA
theaflavin-3,3'-digallate results in increased expression of GDF9 mRNA

NCBI chr10:37,589,200...37,599,970
Ensembl chr10:37,595,679...37,599,672

G

glycerophosphodiester phosphodiesterase domain containing 3

affects expression

theaflavin-3,3'-digallate affects the expression of GDPD3 mRNA

NCBI chr 1:181,373,505...181,383,063
Ensembl chr 1:181,366,626...181,383,063

G

growth factor independent 1B transcriptional repressor

affects expression

theaflavin-3,3'-digallate affects the expression of GFI1B mRNA

NCBI chr 3:11,940,232...11,952,989
Ensembl chr 3:11,940,233...11,952,942

G

growth hormone secretagogue receptor

affects expression

theaflavin-3,3'-digallate affects the expression of GHSR mRNA

NCBI chr 2:110,268,489...110,271,865
Ensembl chr 2:110,268,489...110,271,865

G

gap junction protein, beta 1

affects expression

theaflavin-3,3'-digallate affects the expression of GJB1 mRNA

NCBI chr X:66,501,848...66,509,783
Ensembl chr X:66,501,820...66,509,925

G

gap junction protein, delta 4

affects expression

theaflavin-3,3'-digallate affects the expression of GJD4 mRNA

NCBI chr17:57,348,844...57,352,601
Ensembl chr17:57,349,877...57,352,446

G

glycosyltransferase 1 domain containing 1

affects expression

theaflavin-3,3'-digallate affects the expression of GLT1D1 mRNA

NCBI chr12:28,975,984...29,049,707
Ensembl chr12:28,975,988...29,049,695

G

G protein subunit alpha transducin 1

affects expression

theaflavin-3,3'-digallate affects the expression of GNAT1 mRNA

NCBI chr 8:108,350,935...108,355,671
Ensembl chr 8:108,350,935...108,355,671

G

glycoprotein V (platelet)

affects expression

theaflavin-3,3'-digallate affects the expression of GP5 mRNA

NCBI chr11:70,443,613...70,446,705
Ensembl chr11:70,443,613...70,446,705

G

G protein-coupled bile acid receptor 1

affects expression

theaflavin-3,3'-digallate affects the expression of GPBAR1 mRNA

NCBI chr 9:75,860,758...75,863,260
Ensembl chr 9:75,860,677...75,863,168

G

G protein-coupled receptor 162

affects expression

theaflavin-3,3'-digallate affects the expression of GPR162 mRNA

NCBI chr 4:157,662,200...157,668,341
Ensembl chr 4:157,662,200...157,668,121

G

G protein-coupled receptor 19

affects expression

theaflavin-3,3'-digallate affects the expression of GPR19 mRNA

NCBI chr 4:167,710,944...167,739,232
Ensembl chr 4:167,710,666...167,741,036

G

G protein-coupled receptor 25

affects expression

theaflavin-3,3'-digallate affects the expression of GPR25 mRNA

NCBI chr13:47,712,815...47,714,721
Ensembl chr13:47,713,592...47,714,671

G

G protein-coupled receptor 82

affects expression

theaflavin-3,3'-digallate affects the expression of GPR82 mRNA

NCBI chr X:9,079,016...9,084,696
Ensembl chr X:9,080,254...9,081,240

G

G protein-coupled receptor 83

affects expression

theaflavin-3,3'-digallate affects the expression of GPR83 mRNA

NCBI chr 8:11,693,540...11,704,028
Ensembl chr 8:11,693,540...11,704,028

G

G protein-coupled receptor 89B

affects expression

theaflavin-3,3'-digallate affects the expression of GPR89B mRNA

NCBI chr 2:184,408,136...184,445,560
Ensembl chr 2:184,401,438...184,445,584

G

glutathione peroxidase 1

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [Galactose results in decreased expression of GPX1 mRNA]; theaflavin-3,3'-digallate inhibits the reaction [TNFSF11 protein results in decreased expression of GPX1 mRNA]

PMID:32694992 PMID:36638877

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutamate ionotropic receptor AMPA type subunit 2

affects expression

theaflavin-3,3'-digallate affects the expression of GRIA2 mRNA

NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510

G

gasdermin C

affects expression

theaflavin-3,3'-digallate affects the expression of GSDMC mRNA

NCBI chr 7:95,594,015...95,606,106
Ensembl chr 7:95,594,015...95,611,344

G

GTP binding protein 6 (putative)

affects expression

theaflavin-3,3'-digallate affects the expression of GTPBP6 mRNA

NCBI chr12:46,574,913...46,578,873
Ensembl chr12:46,574,435...46,578,873

G

guanylate cyclase 2C

affects expression

theaflavin-3,3'-digallate affects the expression of GUCY2C mRNA

NCBI chr 4:169,568,505...169,649,092
Ensembl chr 4:169,568,529...169,649,092

G

H1.8 linker histone

affects expression

theaflavin-3,3'-digallate affects the expression of H1FOO mRNA

NCBI chr 4:148,993,133...148,998,254
Ensembl chr 4:148,993,133...148,998,254

G

H2A.X variant histone

decreases expression

theaflavin-3,3'-digallate results in decreased expression of H2AX protein

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239

G

heart and neural crest derivatives expressed 1

affects expression

theaflavin-3,3'-digallate affects the expression of HAND1 mRNA

NCBI chr10:42,006,646...42,009,213
Ensembl chr10:42,006,651...42,009,213

G

homocysteine inducible ER protein with ubiquitin like domain 1

affects expression

theaflavin-3,3'-digallate affects the expression of HERPUD1 mRNA

NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424

G

hes family bHLH transcription factor 1

affects expression

theaflavin-3,3'-digallate affects the expression of HES1 mRNA

NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192

G

hes-related family bHLH transcription factor with YRPW motif 1

affects expression

theaflavin-3,3'-digallate affects the expression of HEY1 mRNA

NCBI chr 2:93,096,605...93,100,316
Ensembl chr 2:93,095,498...93,100,312

G

homogentisate 1, 2-dioxygenase

affects expression

theaflavin-3,3'-digallate affects the expression of HGD mRNA

NCBI chr11:63,086,750...63,138,325
Ensembl chr11:63,086,752...63,138,323

G

hedgehog acyltransferase-like

affects expression

theaflavin-3,3'-digallate affects the expression of HHATL mRNA

NCBI chr 8:121,447,001...121,454,070
Ensembl chr 8:121,447,002...121,454,001

G

HHIP like 2

affects expression

theaflavin-3,3'-digallate affects the expression of HHIPL2 mRNA

NCBI chr13:95,054,685...95,074,609
Ensembl chr13:95,054,694...95,074,608

G

hypoxia inducible factor 1 subunit alpha

decreases expression
multiple interactions

theaflavin-3,3'-digallate results in decreased expression of HIF1A protein
[Methotrexate co-treated with theaflavin-3,3'-digallate] results in decreased expression of HIF1A protein

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

heme oxygenase 1

increases expression
multiple interactions

theaflavin-3,3'-digallate results in increased expression of HMOX1 protein
theaflavin-3,3'-digallate inhibits the reaction [TNFSF11 protein results in decreased expression of HMOX1 mRNA]

PMID:32694992 PMID:35847580

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

H6 family homeobox 1

affects expression

theaflavin-3,3'-digallate affects the expression of HMX1 mRNA

NCBI chr14:75,361,207...75,364,993
Ensembl chr14:75,361,225...75,364,993

G

HORMA domain containing 1

affects expression

theaflavin-3,3'-digallate affects the expression of HORMAD1 mRNA

NCBI chr 2:183,115,815...183,152,383
Ensembl chr 2:183,116,716...183,152,383

G

HORMA domain containing 2

affects expression

theaflavin-3,3'-digallate affects the expression of HORMAD2 mRNA

NCBI chr14:79,215,013...79,300,447
Ensembl chr14:79,214,998...79,299,910

G

homeobox A10

affects expression

theaflavin-3,3'-digallate affects the expression of HOXA10 mRNA

NCBI chr 4:81,331,591...81,340,878
Ensembl chr 4:81,331,591...81,340,919

G

homeo box C10

affects expression

theaflavin-3,3'-digallate affects the expression of HOXC10 mRNA

NCBI chr 7:134,103,741...134,108,966
Ensembl chr 7:134,103,643...134,108,966

G

heparan sulfate-glucosamine 3-sulfotransferase 5

affects expression

theaflavin-3,3'-digallate affects the expression of HS3ST5 mRNA

NCBI chr20:40,106,876...40,417,661
Ensembl chr20:40,106,876...40,417,653

G

heat shock protein family A (Hsp70) member 1A

decreases expression
multiple interactions

theaflavin-3,3'-digallate results in decreased expression of HSPA1A protein
[Methotrexate co-treated with theaflavin-3,3'-digallate] results in decreased expression of HSPA1A protein

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 5

multiple interactions
decreases expression

[Methotrexate co-treated with theaflavin-3,3'-digallate] results in decreased expression of HSPA5 protein
theaflavin-3,3'-digallate results in decreased expression of HSPA5 protein

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family A (Hsp70) member 8

affects expression

theaflavin-3,3'-digallate affects the expression of HSPA8 mRNA

NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259

G

5-hydroxytryptamine receptor 1D

affects expression

theaflavin-3,3'-digallate affects the expression of HTR1D mRNA

NCBI chr 5:148,656,252...148,676,532
Ensembl chr 5:148,674,495...148,675,619

G

5-hydroxytryptamine receptor 5A

affects expression

theaflavin-3,3'-digallate affects the expression of HTR5A mRNA

NCBI chr 4:7,444,968...7,454,651
Ensembl chr 4:7,444,968...7,454,651

G

HUS1 checkpoint clamp component B

affects expression

theaflavin-3,3'-digallate affects the expression of HUS1B mRNA

NCBI chr17:33,534,032...33,535,199

G

inhibitor of DNA binding 3

affects expression

theaflavin-3,3'-digallate affects the expression of ID3 mRNA

NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349

G

immediate early response 5-like

affects expression

theaflavin-3,3'-digallate affects the expression of IER5L mRNA

NCBI chr 3:13,744,056...13,745,647
Ensembl chr 3:13,744,078...13,745,647

G

immunoglobulin superfamily, DCC subclass, member 3

affects expression

theaflavin-3,3'-digallate affects the expression of IGDCC3 mRNA

NCBI chr 8:65,661,165...65,707,961
Ensembl chr 8:65,661,196...65,707,959

G

interleukin 10

affects expression
multiple interactions

theaflavin-3,3'-digallate affects the expression of IL10 mRNA
theaflavin-3,3'-digallate results in increased expression of and results in increased secretion of IL10 protein

PMID:33833684 PMID:34925699

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 13

affects expression

theaflavin-3,3'-digallate affects the expression of IL13 mRNA

NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737

G

interleukin 19

affects expression

theaflavin-3,3'-digallate affects the expression of IL19 mRNA

NCBI chr13:42,397,715...42,411,637
Ensembl chr13:42,399,138...42,405,473

G

interleukin 1 beta

decreases secretion
multiple interactions

theaflavin-3,3'-digallate results in decreased secretion of IL1B protein
theaflavin-3,3'-digallate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B mRNA]; theaflavin-3,3'-digallate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL1B protein]
theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in decreased expression of ACAN mRNA]; theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in decreased expression of ACAN protein]; theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in decreased expression of COL2A1 mRNA]; theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in decreased expression of COL2A1 protein]; theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in decreased expression of SOX9 mRNA]; theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in decreased expression of SOX9 protein]; theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in increased abundance of and results in increased secretion of Dinoprostone]; theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in increased expression of ADAMTS5 mRNA]; theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in increased expression of ADAMTS5 protein]; theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in increased expression of IL6 mRNA]; theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in increased expression of MMP3 protein]; theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in increased expression of NOS2 protein]; theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in increased expression of TNF mRNA]; theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in increased phosphorylation of AKT1 protein]; theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in increased phosphorylation of and results in decreased expression of NFKBIA protein]; theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK1 protein]; theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK3 protein]; theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in increased phosphorylation of RELA protein]; theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in increased secretion of IL1B protein]; theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in increased secretion of IL6 protein]; theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in increased secretion of TNF protein]

PMID:27871911 PMID:30874838 PMID:33833684 PMID:35847580 PMID:37651426

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 2

decreases expression

theaflavin-3,3'-digallate results in decreased expression of IL2 mRNA

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 5 receptor subunit alpha

affects expression

theaflavin-3,3'-digallate affects the expression of IL5RA mRNA

NCBI chr 4:139,630,652...139,664,593
Ensembl chr 4:139,632,066...139,668,544

G

interleukin 6

multiple interactions
decreases secretion

theaflavin-3,3'-digallate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]; theaflavin-3,3'-digallate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL6 protein]
theaflavin-3,3'-digallate results in decreased secretion of IL6 protein
theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in increased expression of IL6 mRNA]; theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in increased secretion of IL6 protein]

PMID:27871911 PMID:30874838 PMID:33833684 PMID:35847580 PMID:37651426

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

innate immunity activator

affects expression

theaflavin-3,3'-digallate affects the expression of INAVA mRNA

NCBI chr13:47,666,446...47,687,383
Ensembl chr13:47,666,447...47,686,729

G

inhibin subunit beta A

affects expression

theaflavin-3,3'-digallate affects the expression of INHBA mRNA

NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982

G

INSM transcriptional repressor 2

affects expression

theaflavin-3,3'-digallate affects the expression of INSM2 mRNA

NCBI chr 6:72,973,861...72,976,453

G

inhibitory synaptic factor family member 2B

affects expression

theaflavin-3,3'-digallate affects the expression of INSYN2B mRNA

NCBI chr10:18,916,721...19,023,859
Ensembl chr10:19,003,131...19,022,139

G

IQ motif containing N

affects expression

theaflavin-3,3'-digallate affects the expression of IQCN mRNA

NCBI chr16:18,716,519...18,733,971
Ensembl chr16:18,716,519...18,726,261

G

IQ motif and ubiquitin domain containing

affects expression

theaflavin-3,3'-digallate affects the expression of IQUB mRNA

NCBI chr 4:52,931,768...52,993,795
Ensembl chr 4:52,931,767...52,993,834

G

immunity related GTPase cinema

affects expression

theaflavin-3,3'-digallate affects the expression of IRGC mRNA

NCBI chr 1:80,020,114...80,025,797
Ensembl chr 1:80,020,079...80,025,802

G

integrin subunit alpha 2b

affects expression

theaflavin-3,3'-digallate affects the expression of ITGA2B mRNA

NCBI chr10:87,408,532...87,426,055
Ensembl chr10:87,408,536...87,426,168

G

integrin subunit beta 6

affects expression

theaflavin-3,3'-digallate affects the expression of ITGB6 mRNA

NCBI chr 3:45,046,295...45,170,532
Ensembl chr 3:45,048,044...45,121,671

G

IZUMO1 receptor, JUNO

affects expression

theaflavin-3,3'-digallate affects the expression of IZUMO1R mRNA

NCBI chr 8:11,744,384...11,748,131
Ensembl chr 8:11,725,863...11,748,465

G

jagged canonical Notch ligand 2

affects expression

theaflavin-3,3'-digallate affects the expression of JAG2 mRNA

NCBI chr 6:131,983,059...132,005,665
Ensembl chr 6:131,983,056...132,005,818

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of JUN protein]

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

potassium voltage-gated channel subfamily E regulatory subunit 3

affects expression

theaflavin-3,3'-digallate affects the expression of KCNE3 mRNA

NCBI chr 1:154,523,903...154,530,865
Ensembl chr 1:154,523,830...154,532,020

G

potassium inwardly-rectifying channel, subfamily J, member 6

affects expression

theaflavin-3,3'-digallate affects the expression of KCNJ6 mRNA

NCBI chr11:34,061,702...34,308,758
Ensembl chr11:34,061,708...34,308,758

G

potassium two pore domain channel subfamily K member 7

affects expression

theaflavin-3,3'-digallate affects the expression of KCNK7 mRNA

NCBI chr 1:202,988,801...202,992,842
Ensembl chr 1:202,990,198...202,992,872

G

potassium sodium-activated channel subfamily T member 1

affects expression

theaflavin-3,3'-digallate affects the expression of KCNT1 mRNA

NCBI chr 3:8,682,964...8,736,615
Ensembl chr 3:8,682,113...8,736,667

G

KIAA1614 homolog

affects expression

theaflavin-3,3'-digallate affects the expression of KIAA1614 mRNA

NCBI chr13:67,388,916...67,427,392
Ensembl chr13:67,389,044...67,421,272

G

KIT proto-oncogene receptor tyrosine kinase

affects expression

theaflavin-3,3'-digallate affects the expression of KIT mRNA

NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652

G

kallikrein related-peptidase 11

affects expression

theaflavin-3,3'-digallate affects the expression of KLK11 mRNA

NCBI chr 1:94,228,741...94,233,281
Ensembl chr 1:94,228,741...94,233,281

G

kallikrein related-peptidase 14

affects expression

theaflavin-3,3'-digallate affects the expression of KLK14 mRNA

NCBI chr 1:94,123,131...94,137,239
Ensembl chr 1:94,131,998...94,137,240

G

keratin 79

affects expression

theaflavin-3,3'-digallate affects the expression of KRT79 mRNA

NCBI chr 7:133,056,710...133,067,750
Ensembl chr 7:133,056,709...133,067,705

G

leukocyte-associated immunoglobulin-like receptor 1

affects expression

theaflavin-3,3'-digallate affects the expression of LAIR1 mRNA

NCBI chr 1:70,068,571...70,187,851
Ensembl chr 1:70,157,681...70,185,807

G

linker for activation of T cells family, member 2

affects expression

theaflavin-3,3'-digallate affects the expression of LAT2 mRNA

NCBI chr12:22,104,173...22,118,294
Ensembl chr12:22,104,219...22,118,288

G

LIM domain binding 2

affects expression

theaflavin-3,3'-digallate affects the expression of LDB2 mRNA

NCBI chr14:66,277,044...66,598,071
Ensembl chr14:66,277,085...66,597,778

G

lactate dehydrogenase A-like 6B

affects expression

theaflavin-3,3'-digallate affects the expression of LDHAL6B mRNA

NCBI chr 1:45,997,845...45,999,268
Ensembl chr 1:45,991,991...45,999,272

G

leptin

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [LEP gene mutant form affects the expression of ACADM mRNA]; theaflavin-3,3'-digallate inhibits the reaction [LEP gene mutant form affects the expression of CYP1A2 mRNA]; theaflavin-3,3'-digallate inhibits the reaction [LEP gene mutant form affects the expression of CYP2C70 mRNA]; theaflavin-3,3'-digallate inhibits the reaction [LEP gene mutant form affects the expression of CYP4F14 mRNA]; theaflavin-3,3'-digallate inhibits the reaction [LEP gene mutant form affects the expression of DHCR7 mRNA]; theaflavin-3,3'-digallate inhibits the reaction [LEP gene mutant form affects the expression of EBP mRNA]; theaflavin-3,3'-digallate inhibits the reaction [LEP gene mutant form affects the expression of ELOVL1 mRNA]; theaflavin-3,3'-digallate inhibits the reaction [LEP gene mutant form affects the expression of FABP4 mRNA]; theaflavin-3,3'-digallate inhibits the reaction [LEP gene mutant form affects the expression of FADS1 mRNA]; theaflavin-3,3'-digallate inhibits the reaction [LEP gene mutant form affects the expression of FDFT1 mRNA]; theaflavin-3,3'-digallate inhibits the reaction [LEP gene mutant form affects the expression of LPL mRNA]; theaflavin-3,3'-digallate inhibits the reaction [LEP gene mutant form affects the expression of PLIN4 mRNA]; theaflavin-3,3'-digallate inhibits the reaction [LEP gene mutant form affects the expression of PPARD mRNA]; theaflavin-3,3'-digallate inhibits the reaction [LEP gene mutant form affects the expression of SCD1 mRNA]; theaflavin-3,3'-digallate inhibits the reaction [LEP gene mutant form affects the expression of TECR mRNA]; theaflavin-3,3'-digallate inhibits the reaction [LEP gene mutant form affects the expression of TM7SF2 mRNA]

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

leucine rich repeat containing G protein coupled receptor 5

affects expression

theaflavin-3,3'-digallate affects the expression of LGR5 mRNA

NCBI chr 7:51,087,059...51,221,882
Ensembl chr 7:51,088,239...51,222,446

G

leukocyte immunoglobulin like receptor B3

affects expression

theaflavin-3,3'-digallate affects the expression of LILRB5 mRNA

NCBI chr 1:69,928,948...69,939,461
Ensembl chr 1:69,928,945...69,939,048

G

lectin, mannose-binding, 1 like

affects expression

theaflavin-3,3'-digallate affects the expression of LMAN1L mRNA

NCBI chr 8:58,010,839...58,029,599
Ensembl chr 8:58,010,839...58,023,681

G

interferon alpha-1-like

affects expression

theaflavin-3,3'-digallate affects the expression of IFNA5 mRNA

NCBI chr 5:103,227,820...103,230,500

G

lipoprotein lipase

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [LEP gene mutant form affects the expression of LPL mRNA]

NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249

G

LDL receptor related protein 1B

affects expression

theaflavin-3,3'-digallate affects the expression of LRP1B mRNA

NCBI chr 3:24,594,302...26,715,037
Ensembl chr 3:24,594,991...26,715,505

G

leucine rich repeat containing 18

affects expression

theaflavin-3,3'-digallate affects the expression of LRRC18 mRNA

NCBI chr16:8,253,524...8,277,141
Ensembl chr16:8,254,352...8,277,437

G

leucine rich repeat containing 66

affects expression

theaflavin-3,3'-digallate affects the expression of LRRC66 mRNA

NCBI chr14:34,578,934...34,604,977
Ensembl chr14:34,581,240...34,604,541

G

leucine-rich single-pass membrane protein 1

affects expression

theaflavin-3,3'-digallate affects the expression of LSMEM1 mRNA

NCBI chr 6:57,251,720...57,261,590
Ensembl chr 6:57,252,056...57,261,653

G

lymphocyte antigen 9

affects expression

theaflavin-3,3'-digallate affects the expression of LY9 mRNA

NCBI chr13:84,079,345...84,100,783
Ensembl chr13:84,079,458...84,100,823

G

mab-21 like 3

affects expression

theaflavin-3,3'-digallate affects the expression of MAB21L3 mRNA

NCBI chr 2:189,248,895...189,271,652
Ensembl chr 2:189,248,895...189,271,652

G

MAF bZIP transcription factor B

affects expression

theaflavin-3,3'-digallate affects the expression of MAFB mRNA

NCBI chr 3:148,998,111...149,000,031
Ensembl chr 3:148,998,122...149,000,031

G

MAM and LDL receptor class A domain containing 1

affects expression

theaflavin-3,3'-digallate affects the expression of MALRD1 mRNA

NCBI chr17:78,418,819...79,131,015
Ensembl chr17:78,418,819...79,131,016

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions
decreases expression

[Methotrexate co-treated with theaflavin-3,3'-digallate] results in decreased expression of MAP1LC3B protein
theaflavin-3,3'-digallate results in decreased expression of MAP1LC3B protein

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690

G

mitogen activated protein kinase kinase 1

decreases expression

theaflavin-3,3'-digallate results in decreased expression of MAP2K1 mRNA; theaflavin-3,3'-digallate results in decreased expression of MAP2K1 protein

NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147

G

mitogen activated protein kinase kinase 2

decreases expression

theaflavin-3,3'-digallate results in decreased expression of MAP2K2 mRNA; theaflavin-3,3'-digallate results in decreased expression of MAP2K2 protein

NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243

G

mitogen activated protein kinase 1

decreases expression
multiple interactions
decreases phosphorylation

theaflavin-3,3'-digallate results in decreased expression of MAPK1 mRNA; theaflavin-3,3'-digallate results in decreased expression of MAPK1 protein
theaflavin-3,3'-digallate inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; theaflavin-3,3'-digallate inhibits the reaction [TNF protein results in decreased phosphorylation of MAPK1 protein]
theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK1 protein]; theaflavin-3,3'-digallate inhibits the reaction [PDGFBB protein results in increased phosphorylation of MAPK1 protein]
theaflavin-3,3'-digallate results in decreased phosphorylation of MAPK1 protein

PMID:16353237 PMID:30874838 PMID:32694992 PMID:32964953 PMID:33833684 More...

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions
decreases phosphorylation
decreases expression

theaflavin-3,3'-digallate inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; theaflavin-3,3'-digallate inhibits the reaction [TNF protein results in decreased phosphorylation of MAPK3 protein]
theaflavin-3,3'-digallate results in decreased phosphorylation of MAPK3 protein
theaflavin-3,3'-digallate results in decreased expression of MAPK3 mRNA; theaflavin-3,3'-digallate results in decreased expression of MAPK3 protein
theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK3 protein]; theaflavin-3,3'-digallate inhibits the reaction [PDGFBB protein results in increased phosphorylation of MAPK3 protein]

PMID:16353237 PMID:30874838 PMID:32694992 PMID:32964953 PMID:33833684 More...

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions
decreases phosphorylation

theaflavin-3,3'-digallate inhibits the reaction [PDGFBB protein results in increased phosphorylation of MAPK8 protein]
theaflavin-3,3'-digallate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK8 protein]
theaflavin-3,3'-digallate results in decreased phosphorylation of MAPK8 protein

PMID:27871911 PMID:32694992 PMID:35903325

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

mitogen-activated protein kinase 9

decreases phosphorylation

theaflavin-3,3'-digallate results in decreased phosphorylation of MAPK9 protein

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

G

matrilin 4

affects expression

theaflavin-3,3'-digallate affects the expression of MATN4 mRNA

NCBI chr 3:153,120,605...153,135,628
Ensembl chr 3:153,120,632...153,135,865

G

meprin A subunit beta

affects expression

theaflavin-3,3'-digallate affects the expression of MEP1B mRNA

NCBI chr18:12,366,126...12,392,840
Ensembl chr18:12,365,289...12,392,840

G

maltase-glucoamylase

affects expression

theaflavin-3,3'-digallate affects the expression of MGAM mRNA

NCBI chr 4:69,441,626...69,602,068
Ensembl chr 4:69,446,150...69,692,715

G

MIA SH3 domain containing

affects expression

theaflavin-3,3'-digallate affects the expression of MIA mRNA

NCBI chr 1:82,473,677...82,476,378
Ensembl chr 1:82,473,678...82,475,370

G

mohawk homeobox

affects expression

theaflavin-3,3'-digallate affects the expression of MKX mRNA

NCBI chr17:55,077,073...55,156,877
Ensembl chr17:55,077,540...55,156,124

G

matrix metallopeptidase 1

decreases expression

theaflavin-3,3'-digallate results in decreased expression of MMP1 protein

NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097

G

matrix metallopeptidase 13

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]

NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239

G

matrix metallopeptidase 17

affects expression

theaflavin-3,3'-digallate affects the expression of MMP17 mRNA

NCBI chr12:27,074,398...27,099,317
Ensembl chr12:27,074,409...27,099,316

G

matrix metallopeptidase 2

decreases expression

theaflavin-3,3'-digallate results in decreased expression of MMP2 protein

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 3

multiple interactions
decreases expression

theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in increased expression of MMP3 protein]
theaflavin-3,3'-digallate results in decreased expression of MMP3 protein

PMID:30874838 PMID:35847580

NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961

G

matrix metallopeptidase 9

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 mRNA]

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

MORN repeat containing 3

affects expression

theaflavin-3,3'-digallate affects the expression of MORN3 mRNA

NCBI chr12:33,505,654...33,529,918
Ensembl chr12:33,514,230...33,529,931

G

MOS proto-oncogene, serine/threonine kinase

affects expression

theaflavin-3,3'-digallate affects the expression of MOS mRNA

NCBI chr 5:16,859,957...16,861,264
Ensembl chr 5:16,859,957...16,861,264

G

MPL proto-oncogene, thrombopoietin receptor

affects expression

theaflavin-3,3'-digallate affects the expression of MPL mRNA

NCBI chr 5:131,973,895...131,987,472
Ensembl chr 5:131,973,895...131,986,797

G

myelin protein zero-like 2

affects expression

theaflavin-3,3'-digallate affects the expression of MPZL2 mRNA

NCBI chr 8:45,348,285...45,359,298
Ensembl chr 8:45,348,285...45,359,298

G

melanocortin 2 receptor accessory protein 2

affects expression

theaflavin-3,3'-digallate affects the expression of MRAP2 mRNA

NCBI chr 8:88,088,293...88,144,636
Ensembl chr 8:88,088,272...88,143,886

G

maestro heat-like repeat family member 2B

affects expression

theaflavin-3,3'-digallate affects the expression of MROH2B mRNA

NCBI chr 2:54,003,870...54,063,992
Ensembl chr 2:54,003,862...54,063,984

G

membrane spanning 4-domains A5

affects expression

theaflavin-3,3'-digallate affects the expression of MS4A5 mRNA

NCBI chr 1:207,927,057...207,934,886
Ensembl chr 1:207,927,052...207,934,836

G

mitochondrial fission regulator 2

affects expression

theaflavin-3,3'-digallate affects the expression of MTFR2 mRNA

NCBI chr 1:15,123,232...15,138,632
Ensembl chr 1:15,070,894...15,148,832

G

mechanistic target of rapamycin kinase

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [PDGFBB protein results in increased phosphorylation of MTOR protein]

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

mucin 13, cell surface associated

affects expression

theaflavin-3,3'-digallate affects the expression of MUC13 mRNA

NCBI chr11:66,957,208...66,980,264
Ensembl chr11:66,960,595...66,984,727

G

mucin 5B, oligomeric mucus/gel-forming

affects expression

theaflavin-3,3'-digallate affects the expression of MUC5B mRNA

NCBI chr 1:196,916,861...196,948,830
Ensembl chr 1:196,916,825...196,949,250

G

myeloid-associated differentiation marker-like 2

affects expression

theaflavin-3,3'-digallate affects the expression of MYADML2 mRNA

NCBI chr10:105,922,557...105,927,867
Ensembl chr10:105,925,947...105,927,575

G

myosin binding protein H-like

affects expression

theaflavin-3,3'-digallate affects the expression of MYBPHL mRNA

NCBI chr 2:196,005,297...196,018,826
Ensembl chr 2:196,005,325...196,018,824

G

myosin heavy chain 11

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [PDGFBB protein results in decreased expression of MYH11 protein]

NCBI chr10:743,364...838,459
Ensembl chr10:743,685...838,459

G

myosin light chain kinase 3

affects expression

theaflavin-3,3'-digallate affects the expression of MYLK3 mRNA

NCBI chr19:21,685,085...21,743,587
Ensembl chr19:21,691,929...21,742,954

G

myosin IA

affects expression

theaflavin-3,3'-digallate affects the expression of MYO1A mRNA

NCBI chr 7:63,542,988...63,557,944
Ensembl chr 7:63,542,988...63,557,944

G

myosin IF

affects expression

theaflavin-3,3'-digallate affects the expression of MYO1F mRNA

NCBI chr 7:14,363,340...14,413,911
Ensembl chr 7:14,363,350...14,413,911

G

myogenic differentiation 1

affects expression

theaflavin-3,3'-digallate affects the expression of MYOD1 mRNA

NCBI chr 1:96,884,864...96,887,574
Ensembl chr 1:96,884,948...96,887,554

G

NALCN channel auxiliary factor 2

affects expression

theaflavin-3,3'-digallate affects the expression of NALF2 mRNA

NCBI chr X:64,925,100...64,951,074
Ensembl chr X:64,925,051...64,951,077

G

neutrophil cytosolic factor 4

affects expression

theaflavin-3,3'-digallate affects the expression of NCF4 mRNA

NCBI chr 7:109,825,420...109,843,389
Ensembl chr 7:109,826,020...109,843,389

G

NCK associated protein 1 like

affects expression

theaflavin-3,3'-digallate affects the expression of NCKAP1L mRNA

NCBI chr 7:134,577,470...134,622,928
Ensembl chr 7:134,577,482...134,622,934

G

neurogenin 2

affects expression

theaflavin-3,3'-digallate affects the expression of NEUROG2 mRNA

NCBI chr 2:216,092,709...216,095,276
Ensembl chr 2:216,093,363...216,094,154

G

nuclear factor of activated T-cells 3

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [AGT protein results in decreased phosphorylation of NFATC3 protein]

NCBI chr19:33,960,643...34,035,150
Ensembl chr19:33,960,852...34,035,150

G

NFE2 like bZIP transcription factor 2

multiple interactions
increases expression

[theaflavin-3,3'-digallate results in increased expression of NFE2L2 protein] inhibits the reaction [TNFSF11 protein results in increased abundance of Reactive Oxygen Species]; [theaflavin-3,3'-digallate results in increased expression of NFE2L2 protein] which results in decreased abundance of Reactive Oxygen Species; theaflavin-3,3'-digallate inhibits the reaction [Galactose results in decreased expression of NFE2L2 mRNA]; theaflavin-3,3'-digallate inhibits the reaction [TNFSF11 protein results in decreased expression of NFE2L2 mRNA]; theaflavin-3,3'-digallate results in increased expression of and affects the localization of NFE2L2 protein

PMID:32694992 PMID:35847580 PMID:36638877

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NFKB inhibitor alpha

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in increased phosphorylation of and results in decreased expression of NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

Sodium/potassium transporting ATPase interacting 3

affects expression

theaflavin-3,3'-digallate affects the expression of NKAIN3 mRNA

NCBI chr 5:33,613,720...34,310,090
Ensembl chr 5:33,623,713...34,309,381

G

NK3 homeobox 2

affects expression

theaflavin-3,3'-digallate affects the expression of NKX3-2 mRNA

NCBI chr14:69,183,795...69,186,182
Ensembl chr14:69,183,820...69,186,061

G

NLR family, pyrin domain containing 4

affects expression

theaflavin-3,3'-digallate affects the expression of NLRP4 mRNA

NCBI chr 1:68,089,321...68,132,429
Ensembl chr 1:68,089,321...68,127,521

G

NLR family, pyrin domain containing 5

affects expression

theaflavin-3,3'-digallate affects the expression of NLRP5 mRNA

NCBI chr 1:67,778,037...67,810,941
Ensembl chr 1:67,777,948...68,023,736

G

nitric oxide synthase 2

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in increased expression of NOS2 protein]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

NOTUM, palmitoleoyl-protein carboxylesterase

affects expression

theaflavin-3,3'-digallate affects the expression of NOTUM mRNA

NCBI chr10:105,933,245...105,940,327
Ensembl chr10:105,933,249...105,940,315

G

NOVA alternative splicing regulator 2

affects expression

theaflavin-3,3'-digallate affects the expression of NOVA2 mRNA

NCBI chr 1:78,572,253...78,613,703
Ensembl chr 1:78,572,279...78,608,021

G

natriuretic peptide A

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [AGT protein results in increased expression of ANP mRNA]

NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351

G

natriuretic peptide B

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [AGT protein results in increased expression of BNP mRNA]

NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168

G

nuclear receptor subfamily 4, group A, member 2

affects expression

theaflavin-3,3'-digallate affects the expression of NR4A2 mRNA

NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877

G

neuregulin 1

affects expression

theaflavin-3,3'-digallate affects the expression of NRG1 mRNA

NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884

G

nucleolar and spindle associated protein 1

affects expression

theaflavin-3,3'-digallate affects the expression of NUSAP1 mRNA

NCBI chr 3:106,603,273...106,633,428
Ensembl chr 3:106,603,289...106,633,624

G

nuclear RNA export factor 7

affects expression

theaflavin-3,3'-digallate affects the expression of NXF5 mRNA

NCBI chr X:98,535,374...98,552,562
Ensembl chr X:98,535,375...98,552,526

G

oligodendrocyte transcription factor 1

affects expression

theaflavin-3,3'-digallate affects the expression of OLIG1 mRNA

NCBI chr11:30,514,379...30,516,521
Ensembl chr11:30,514,379...30,516,521

G

oligodendrocyte-myelin glycoprotein

affects expression

theaflavin-3,3'-digallate affects the expression of OMG mRNA

NCBI chr10:64,461,350...64,464,084
Ensembl chr10:64,461,350...64,464,084

G

opsin 1, short wave sensitive

affects expression

theaflavin-3,3'-digallate affects the expression of OPN1SW mRNA

NCBI chr 4:57,977,317...57,980,457
Ensembl chr 4:57,977,313...57,980,457

G

olfactory receptor family 2 subfamily A member 25

affects expression

theaflavin-3,3'-digallate affects the expression of OR2A25 mRNA

NCBI chr 4:71,878,578...71,879,519
Ensembl chr 4:71,878,578...71,879,519

G

olfactory receptor family 2 subfamily K member 2

affects expression

theaflavin-3,3'-digallate affects the expression of OR2K2 mRNA

NCBI chr 5:73,582,686...73,583,627
Ensembl chr 5:73,581,080...73,585,725

G

olfactory receptor family 51 subfamily I member 1

affects expression

theaflavin-3,3'-digallate affects the expression of OR51I1 mRNA

NCBI chr 1:158,502,581...158,503,525
Ensembl chr 1:158,502,362...158,506,799

G

olfactory receptor family 5 subfamily B member 99

affects expression

theaflavin-3,3'-digallate affects the expression of OR5B2 mRNA

NCBI chr 1:210,136,841...210,137,767
Ensembl chr 1:210,132,946...210,138,365

G

otolin 1

affects expression

theaflavin-3,3'-digallate affects the expression of OTOL1 mRNA

NCBI chr 2:154,339,612...154,349,050
Ensembl chr 2:154,339,612...154,349,023

G

otoraplin

affects expression

theaflavin-3,3'-digallate affects the expression of OTOR mRNA

NCBI chr 3:130,415,339...130,418,601
Ensembl chr 3:130,415,339...130,418,601

G

orthopedia homeobox

affects expression

theaflavin-3,3'-digallate affects the expression of OTP mRNA

NCBI chr 2:26,108,158...26,116,359
Ensembl chr 2:26,108,163...26,116,359

G

orthodenticle homeobox 2

affects expression

theaflavin-3,3'-digallate affects the expression of OTX2 mRNA

NCBI chr15:21,942,233...21,953,034
Ensembl chr15:21,943,191...21,953,416

G

peptidyl arginine deiminase 6

affects expression

theaflavin-3,3'-digallate affects the expression of PADI6 mRNA

NCBI chr 5:153,021,855...153,037,443
Ensembl chr 5:153,021,965...153,037,414

G

poly (ADP-ribose) polymerase 1

increases cleavage

theaflavin-3,3'-digallate results in increased cleavage of PARP1 protein

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

prostate and testis expressed 1

affects expression

theaflavin-3,3'-digallate affects the expression of PATE1 mRNA

NCBI chr 8:34,048,410...34,050,867
Ensembl chr 8:34,048,617...34,050,848

G

paired box 3

affects expression

theaflavin-3,3'-digallate affects the expression of PAX3 mRNA

NCBI chr 9:79,567,455...79,664,042
Ensembl chr 9:79,568,634...79,664,042

G

PBX homeobox 4

affects expression

theaflavin-3,3'-digallate affects the expression of PBX4 mRNA

NCBI chr16:19,555,089...19,590,054
Ensembl chr16:19,555,090...19,590,014

G

protocadherin alpha 5

affects expression

theaflavin-3,3'-digallate affects the expression of PCDHA5 mRNA

Ensembl chr18:28,581,225...28,846,211

G

Purkinje cell protein 4-like 1

affects expression

theaflavin-3,3'-digallate affects the expression of PCP4L1 mRNA

NCBI chr13:83,588,992...83,612,631
Ensembl chr13:83,588,992...83,609,966

G

proprotein convertase subtilisin/kexin type 2

affects expression

theaflavin-3,3'-digallate affects the expression of PCSK2 mRNA

NCBI chr 3:130,880,422...131,183,127
Ensembl chr 3:130,880,422...131,183,127

G

phosphodiesterase 2A

affects expression

theaflavin-3,3'-digallate affects the expression of PDE2A mRNA

NCBI chr 1:155,823,590...155,915,434
Ensembl chr 1:155,813,180...155,915,434

G

phosphodiesterase 3A

affects expression

theaflavin-3,3'-digallate affects the expression of PDE3A mRNA

NCBI chr 4:174,172,804...174,443,944
Ensembl chr 4:174,172,868...174,438,274

G

platelet derived growth factor receptor beta

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [PDGFBB protein results in increased phosphorylation of PDGFRB protein]

NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843

G

peroxisomal biogenesis factor 5-like

affects expression

theaflavin-3,3'-digallate affects the expression of PEX5L mRNA

NCBI chr 2:115,694,868...115,908,365
Ensembl chr 2:115,700,972...115,913,628

G

phosphoethanolamine/phosphocholine phosphatase 1

affects expression

theaflavin-3,3'-digallate affects the expression of PHOSPHO1 mRNA

NCBI chr10:80,762,062...80,769,596
Ensembl chr10:80,760,792...80,770,342

G

polycystin 1 like 1, transient receptor potential channel interacting

affects expression

theaflavin-3,3'-digallate affects the expression of PKD1L1 mRNA

NCBI chr14:83,552,964...83,670,062
Ensembl chr14:83,545,469...83,638,498

G

polycystin 1 like 3, transient receptor potential channel interacting

affects expression

theaflavin-3,3'-digallate affects the expression of PKD1L3 mRNA

NCBI chr19:37,585,564...37,650,083
Ensembl chr19:37,585,725...37,650,155

G

polycystin family receptor for egg jelly

affects expression

theaflavin-3,3'-digallate affects the expression of PKDREJ mRNA

NCBI chr 7:116,909,094...116,915,468
Ensembl chr 7:116,909,094...116,915,468

G

phospholipase A2, group XIIB

affects expression

theaflavin-3,3'-digallate affects the expression of PLA2G12B mRNA

NCBI chr20:27,369,196...27,389,517
Ensembl chr20:27,370,266...27,388,743

G

phospholipase A2, group IIF

affects expression

theaflavin-3,3'-digallate affects the expression of PLA2G2F mRNA

NCBI chr 5:150,986,788...150,993,175
Ensembl chr 5:150,986,788...150,993,175

G

phospholipase C, gamma 1

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [PDGFBB protein results in increased phosphorylation of PLCG1 protein]

NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330

G

pleckstrin homology domain containing A6

affects expression

theaflavin-3,3'-digallate affects the expression of PLEKHA6 mRNA

NCBI chr13:44,614,740...44,754,951
Ensembl chr13:44,615,011...44,754,673

G

perilipin 1

affects expression

theaflavin-3,3'-digallate affects the expression of PLIN1 mRNA

NCBI chr 1:133,664,294...133,676,854
Ensembl chr 1:133,664,892...133,676,828

G

perilipin 4

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [LEP gene mutant form affects the expression of PLIN4 mRNA]

NCBI chr 9:929,168...938,062
Ensembl chr 9:929,176...938,056

G

phospholipid phosphatase 2

affects expression

theaflavin-3,3'-digallate affects the expression of PLPP2 mRNA

NCBI chr 7:10,175,918...10,184,032
Ensembl chr 7:10,175,948...10,184,071

G

peripheral myelin protein 2

affects expression

theaflavin-3,3'-digallate affects the expression of PMP2 mRNA

NCBI chr 2:91,611,334...91,615,252
Ensembl chr 2:91,611,334...91,615,252

G

peroxisome proliferator-activated receptor delta

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [LEP gene mutant form affects the expression of PPARD mRNA]

NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968

G

protein phosphatase with EF-hand domain 2

affects expression

theaflavin-3,3'-digallate affects the expression of PPEF2 mRNA

NCBI chr14:15,797,414...15,831,620
Ensembl chr14:15,797,435...15,831,491

G

protein phosphatase 3 catalytic subunit alpha

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [AGT protein results in increased expression of PPP3CA protein]

NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974

G

proline-rich acidic protein 1

affects expression

theaflavin-3,3'-digallate affects the expression of PRAP1 mRNA

NCBI chr 1:194,883,078...194,886,874
Ensembl chr 1:194,883,078...194,886,872

G

peroxiredoxin 2

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [Galactose results in decreased expression of PRDX2 mRNA]

NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194

G

protein kinase AMP-activated non-catalytic subunit gamma 3

affects expression

theaflavin-3,3'-digallate affects the expression of PRKAG3 mRNA

NCBI chr 9:76,295,715...76,304,959
Ensembl chr 9:76,295,715...76,304,959

G

prokineticin receptor 1

affects expression

theaflavin-3,3'-digallate affects the expression of PROKR1 mRNA

NCBI chr 4:120,022,301...120,033,367
Ensembl chr 4:120,021,747...120,033,379

G

protein Z, vitamin K-dependent plasma glycoprotein

affects expression

theaflavin-3,3'-digallate affects the expression of PROZ mRNA

NCBI chr16:76,450,013...76,463,558
Ensembl chr16:76,450,013...76,463,480

G

pre T-cell antigen receptor alpha

affects expression

theaflavin-3,3'-digallate affects the expression of PTCRA mRNA

NCBI chr 9:14,218,907...14,229,141
Ensembl chr 9:14,218,802...14,229,235

G

prostaglandin D2 receptor 2

affects expression

theaflavin-3,3'-digallate affects the expression of PTGDR2 mRNA

NCBI chr 1:207,585,088...207,590,275
Ensembl chr 1:207,587,917...207,589,213

G

prostaglandin I2 receptor

affects expression

theaflavin-3,3'-digallate affects the expression of PTGIR mRNA

NCBI chr 1:77,579,596...77,581,979
Ensembl chr 1:77,579,596...77,581,979

G

prostaglandin-endoperoxide synthase 2

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

glycogen phosphorylase, muscle associated

affects expression

theaflavin-3,3'-digallate affects the expression of PYGM mRNA

NCBI chr 1:203,690,550...203,705,369
Ensembl chr 1:203,690,533...203,705,368

G

peptide YY

affects expression

theaflavin-3,3'-digallate affects the expression of PYY mRNA

NCBI chr10:87,061,155...87,062,278
Ensembl chr10:87,061,161...87,061,815

G

RAB39A, member RAS oncogene family

affects expression

theaflavin-3,3'-digallate affects the expression of RAB39A mRNA

NCBI chr 8:54,088,246...54,105,867
Ensembl chr 8:54,088,129...54,106,483

G

RAB44, member RAS oncogene family

affects expression

theaflavin-3,3'-digallate affects the expression of RAB44 mRNA

NCBI chr20:7,164,576...7,198,473
Ensembl chr20:7,164,720...7,198,468

G

RB transcriptional corepressor 1

multiple interactions

CDKN1B promotes the reaction [theaflavin-3,3'-digallate results in decreased expression of and results in decreased phosphorylation of RB1 protein]; theaflavin-3,3'-digallate results in decreased expression of and results in decreased phosphorylation of RB1 protein

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

RNA binding fox-1 homolog 3

affects expression

theaflavin-3,3'-digallate affects the expression of RBFOX3 mRNA

NCBI chr10:103,720,355...104,157,277
Ensembl chr10:103,720,636...104,156,935

G

retinol binding protein 7

affects expression

theaflavin-3,3'-digallate affects the expression of RBP7 mRNA

NCBI chr 5:159,889,723...159,894,338
Ensembl chr 5:159,889,723...159,894,339

G

regulator of calcineurin 2

affects expression

theaflavin-3,3'-digallate affects the expression of RCAN2 mRNA

NCBI chr 9:16,959,478...17,174,823
Ensembl chr 9:16,959,480...17,174,856

G

recoverin

affects expression

theaflavin-3,3'-digallate affects the expression of RCVRN mRNA

NCBI chr10:52,388,706...52,396,454
Ensembl chr10:52,388,706...52,396,453

G

RD3 regulator of GUCY2D

affects expression

theaflavin-3,3'-digallate affects the expression of RD3 mRNA

NCBI chr13:103,551,823...103,562,925
Ensembl chr13:103,552,857...103,562,622

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of RELA protein]; theaflavin-3,3'-digallate results in decreased expression of and affects the localization of RELA protein
theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in increased phosphorylation of RELA protein]

PMID:27871911 PMID:30874838 PMID:35847580

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

resistin

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [Methylmercury Compounds results in increased secretion of RETN protein]

NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620

G

regulatory factor X, 6

affects expression

theaflavin-3,3'-digallate affects the expression of RFX6 mRNA

NCBI chr20:31,019,784...31,073,266
Ensembl chr20:31,019,829...31,073,147

G

regulator of G-protein signaling 18

affects expression

theaflavin-3,3'-digallate affects the expression of RGS18 mRNA

NCBI chr13:56,493,134...56,516,045
Ensembl chr13:56,494,010...56,516,098

G

ras homolog family member H

affects expression

theaflavin-3,3'-digallate affects the expression of RHOH mRNA

NCBI chr14:42,341,135...42,371,971
Ensembl chr14:42,337,751...42,386,369

G

ring finger protein 152

affects expression

theaflavin-3,3'-digallate affects the expression of RNF152 mRNA

NCBI chr13:21,324,039...21,403,405
Ensembl chr13:21,323,824...21,403,113

G

R-spondin 1

affects expression

theaflavin-3,3'-digallate affects the expression of RSPO1 mRNA

NCBI chr 5:137,251,629...137,273,273
Ensembl chr 5:137,251,659...137,272,933

G

R-spondin 2

affects expression

theaflavin-3,3'-digallate affects the expression of RSPO2 mRNA

NCBI chr 7:74,096,378...74,239,398
Ensembl chr 7:74,103,090...74,238,933

G

RUNX family transcription factor 2

multiple interactions
increases expression

theaflavin-3,3'-digallate inhibits the reaction [TNF protein results in decreased expression of RUNX2 protein]
theaflavin-3,3'-digallate results in increased expression of RUNX2 protein

NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167

G

stearoyl-CoA desaturase

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [LEP gene mutant form affects the expression of SCD1 mRNA]

NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562

G

sodium channel epithelial 1 subunit beta

affects expression

theaflavin-3,3'-digallate affects the expression of SCNN1B mRNA

NCBI chr 1:176,430,063...176,484,451
Ensembl chr 1:176,430,103...176,484,451

G

scleraxis bHLH transcription factor

affects expression

theaflavin-3,3'-digallate affects the expression of SCX mRNA

NCBI chr 7:108,176,608...108,178,626
Ensembl chr 7:108,176,608...108,178,626

G

short chain dehydrogenase/reductase family 42E, member 1

affects expression

theaflavin-3,3'-digallate affects the expression of SDR42E1 mRNA

NCBI chr19:45,715,366...45,727,901
Ensembl chr19:45,715,399...45,727,901

G

selectin P

affects expression

theaflavin-3,3'-digallate affects the expression of SELP mRNA

NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845

G

selectin P ligand

affects expression

theaflavin-3,3'-digallate affects the expression of SELPLG mRNA

NCBI chr12:42,796,690...42,809,908
Ensembl chr12:42,796,580...42,812,585

G

serine incorporator 4

affects expression

theaflavin-3,3'-digallate affects the expression of SERINC4 mRNA

NCBI chr 3:108,428,896...108,434,778
Ensembl chr 3:108,428,897...108,434,778

G

serpin family A member 6

affects expression

theaflavin-3,3'-digallate affects the expression of SERPINA6 mRNA

NCBI chr 6:122,780,040...122,790,274
Ensembl chr 6:122,780,043...122,790,349

G

serpin family B member 10

affects expression

theaflavin-3,3'-digallate affects the expression of SERPINB10 mRNA

NCBI chr13:23,553,348...23,571,182
Ensembl chr13:23,553,430...23,571,182

G

serpin family B member 5

affects expression

theaflavin-3,3'-digallate affects the expression of SERPINB5 mRNA

NCBI chr13:22,985,557...23,005,756
Ensembl chr13:22,985,557...23,005,756

G

serpin family C member 1

affects expression

theaflavin-3,3'-digallate affects the expression of SERPINC1 mRNA

NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293

G

stratifin

affects expression

theaflavin-3,3'-digallate affects the expression of SFN mRNA

NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314

G

SH2 domain containing 4B

affects expression

theaflavin-3,3'-digallate affects the expression of SH2D4B mRNA

NCBI chr16:16,673,518...16,783,076
Ensembl chr16:16,677,889...16,769,087

G

SH2 domain containing 7

affects expression

theaflavin-3,3'-digallate affects the expression of SH2D7 mRNA

NCBI chr 8:54,918,399...54,930,129
Ensembl chr 8:54,918,406...54,929,726

G

sialic acid binding Ig like lectin 1

affects expression

theaflavin-3,3'-digallate affects the expression of SIGLEC1 mRNA

NCBI chr 3:118,287,988...118,307,125
Ensembl chr 3:118,287,988...118,306,850

G

SLAM family member 8

affects expression

theaflavin-3,3'-digallate affects the expression of SLAMF8 mRNA

NCBI chr13:85,047,729...85,057,571
Ensembl chr13:85,047,727...85,057,211

G

solute carrier family 10 member 6

affects expression

theaflavin-3,3'-digallate affects the expression of SLC10A6 mRNA

NCBI chr14:6,080,716...6,102,902
Ensembl chr14:6,080,717...6,103,037

G

solute carrier family 17 member 8

affects expression

theaflavin-3,3'-digallate affects the expression of SLC17A8 mRNA

NCBI chr 7:23,994,212...24,049,498
Ensembl chr 7:23,994,217...24,048,079

G

solute carrier family 20 member 1

affects expression

theaflavin-3,3'-digallate affects the expression of SLC20A1 mRNA

NCBI chr 3:116,427,095...116,441,049
Ensembl chr 3:116,427,098...116,441,051

G

solute carrier family 22 member 13

affects expression

theaflavin-3,3'-digallate affects the expression of SLC22A13 mRNA

NCBI chr 8:118,922,367...118,934,020
Ensembl chr 8:118,922,367...118,953,635

G

solute carrier family 22 member 20

affects expression

theaflavin-3,3'-digallate affects the expression of SLC22A20 mRNA

NCBI chr 1:203,257,374...203,273,854
Ensembl chr 1:203,257,374...203,273,822

G

solute carrier family 35, member F3

affects expression

theaflavin-3,3'-digallate affects the expression of SLC35F3 mRNA

NCBI chr19:54,102,811...54,371,765
Ensembl chr19:54,103,120...54,372,839

G

solute carrier family 45, member 2

affects expression

theaflavin-3,3'-digallate affects the expression of SLC45A2 mRNA

NCBI chr 2:59,963,599...59,996,408
Ensembl chr 2:59,963,706...59,996,317

G

solute carrier family 6 member 12

affects expression

theaflavin-3,3'-digallate affects the expression of SLC6A12 mRNA

NCBI chr 4:154,585,386...154,603,750
Ensembl chr 4:154,585,500...154,603,750

G

solute carrier family 6 member 13

affects expression

theaflavin-3,3'-digallate affects the expression of SLC6A13 mRNA

NCBI chr 4:154,539,246...154,577,784
Ensembl chr 4:154,540,468...154,576,152

G

solute carrier family 6 member 20a

affects expression

theaflavin-3,3'-digallate affects the expression of SLC6A20 mRNA

NCBI chr 8:123,282,325...123,322,609
Ensembl chr 8:123,281,472...123,322,573

G

solute carrier family 6 member 3

affects expression

theaflavin-3,3'-digallate affects the expression of SLC6A3 mRNA

NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413

G

solute carrier family 6 member 4

affects expression

theaflavin-3,3'-digallate affects the expression of SLC6A4 mRNA

NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384

G

solute carrier family 6 member 7

affects expression

theaflavin-3,3'-digallate affects the expression of SLC6A7 mRNA

NCBI chr18:54,448,464...54,467,319
Ensembl chr18:54,448,464...54,467,319

G

solute carrier organic anion transporter family, member 1a4

affects expression

theaflavin-3,3'-digallate affects the expression of SLCO1A2 mRNA

NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573

G

solute carrier organic anion transporter family, member 2b1

affects expression

theaflavin-3,3'-digallate affects the expression of SLCO2B1 mRNA

NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353

G

slit guidance ligand 1

affects expression

theaflavin-3,3'-digallate affects the expression of SLIT1 mRNA

NCBI chr 1:240,409,559...240,558,127
Ensembl chr 1:240,409,561...240,558,127

G

small integral membrane protein 23

affects expression

theaflavin-3,3'-digallate affects the expression of SMIM23 mRNA

NCBI chr10:17,403,456...17,407,091
Ensembl chr10:17,403,456...17,407,168

G

superoxide dismutase 1

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [Galactose results in decreased expression of SOD1 mRNA]

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

increases expression

theaflavin-3,3'-digallate results in increased expression of SOD2 protein

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

sclerostin domain containing 1

affects expression

theaflavin-3,3'-digallate affects the expression of SOSTDC1 mRNA

NCBI chr 6:53,051,336...53,055,510
Ensembl chr 6:53,051,354...53,055,579

G

sosondowah ankyrin repeat domain family member A

affects expression

theaflavin-3,3'-digallate affects the expression of SOWAHA mRNA

NCBI chr10:37,641,823...37,645,390
Ensembl chr10:37,643,444...37,645,102

G

sosondowah ankyrin repeat domain family member B

affects expression

theaflavin-3,3'-digallate affects the expression of SOWAHB mRNA

NCBI chr14:15,029,203...15,033,038
Ensembl chr14:15,029,395...15,031,698

G

SRY-box transcription factor 15

affects expression

theaflavin-3,3'-digallate affects the expression of SOX15 mRNA

NCBI chr10:54,373,045...54,374,749
Ensembl chr10:54,372,403...54,376,591

G

SRY-box transcription factor 30

affects expression

theaflavin-3,3'-digallate affects the expression of SOX30 mRNA

NCBI chr10:30,417,499...30,446,441
Ensembl chr10:30,418,473...30,446,453

G

SRY-box transcription factor 9

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in decreased expression of SOX9 mRNA]; theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in decreased expression of SOX9 protein]

NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994

G

Sp1 transcription factor

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [EGF protein results in increased activity of SP1 protein]

NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961

G

Sp7 transcription factor

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [TNF protein results in decreased expression of SP7 protein]

NCBI chr 7:133,484,609...133,494,788
Ensembl chr 7:133,484,609...133,494,847

G

sperm acrosome developmental regulator

affects expression

theaflavin-3,3'-digallate affects the expression of SPACDR mRNA

NCBI chr12:18,930,608...18,936,787
Ensembl chr12:18,914,398...18,952,008

G

speedy/RINGO cell cycle regulator family member A

affects expression

theaflavin-3,3'-digallate affects the expression of SPDYA mRNA

NCBI chr 6:23,905,574...23,954,926
Ensembl chr 6:23,910,223...23,954,850

G

serine peptidase inhibitor, Kazal type 2

affects expression

theaflavin-3,3'-digallate affects the expression of SPINK2 mRNA

NCBI chr14:30,967,682...30,974,326
Ensembl chr14:30,967,714...30,974,326

G

sprouty RTK signaling antagonist 4

affects expression

theaflavin-3,3'-digallate affects the expression of SPRY4 mRNA

NCBI chr18:30,436,513...30,451,426
Ensembl chr18:30,436,443...30,453,004

G

spexin hormone

affects expression

theaflavin-3,3'-digallate affects the expression of SPX mRNA

NCBI chr 4:175,356,044...175,362,082
Ensembl chr 4:175,356,247...175,362,082

G

sequestosome 1

multiple interactions

[Methotrexate co-treated with theaflavin-3,3'-digallate] results in decreased expression of SQSTM1 protein

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

SRC proto-oncogene, non-receptor tyrosine kinase

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [PDGFBB protein results in increased phosphorylation of SRC protein]

NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476

G

somatostatin

affects expression

theaflavin-3,3'-digallate affects the expression of SST mRNA

NCBI chr11:76,956,896...76,958,173
Ensembl chr11:76,956,896...76,958,173

G

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6

affects expression

theaflavin-3,3'-digallate affects the expression of ST8SIA6 mRNA

NCBI chr17:76,740,755...76,884,178
Ensembl chr17:76,745,224...76,884,299

G

stabilin 1

affects expression

theaflavin-3,3'-digallate affects the expression of STAB1 mRNA

NCBI chr16:6,330,435...6,360,934
Ensembl chr16:6,330,444...6,360,923

G

SH3 and cysteine rich domain 2

affects expression

theaflavin-3,3'-digallate affects the expression of STAC2 mRNA

NCBI chr10:83,032,418...83,048,260
Ensembl chr10:83,032,417...83,048,260

G

serine threonine kinase 31

affects expression

theaflavin-3,3'-digallate affects the expression of STK31 mRNA

NCBI chr 4:78,370,691...78,467,599
Ensembl chr 4:78,370,649...78,466,240

G

serine/threonine kinase 32B

affects expression

theaflavin-3,3'-digallate affects the expression of STK32B mRNA

NCBI chr14:73,077,944...73,337,976
Ensembl chr14:73,078,061...73,336,458

G

SVOP like

affects expression

theaflavin-3,3'-digallate affects the expression of SVOPL mRNA

NCBI chr 4:66,697,550...66,751,699
Ensembl chr 4:66,698,177...66,758,978

G

synaptonemal complex protein 2

affects expression

theaflavin-3,3'-digallate affects the expression of SYCP2 mRNA

NCBI chr 3:165,431,715...165,502,134
Ensembl chr 3:165,436,331...165,498,789

G

synaptonemal complex protein 3

affects expression

theaflavin-3,3'-digallate affects the expression of SYCP3 mRNA

NCBI chr 7:22,874,055...22,888,512
Ensembl chr 7:22,874,055...22,888,511

G

synapse differentiation inducing 1-like

affects expression

theaflavin-3,3'-digallate affects the expression of SYNDIG1L mRNA

NCBI chr 6:104,318,096...104,344,989
Ensembl chr 6:104,323,424...104,344,891

G

tachykinin precursor 4

affects expression

theaflavin-3,3'-digallate affects the expression of TAC4 mRNA

NCBI chr10:80,207,824...80,216,156
Ensembl chr10:80,207,610...80,216,156

G

transgelin

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [PDGFBB protein results in decreased expression of TAGLN protein]

NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668

G

TRPM8 channel-associated factor 2

affects expression

theaflavin-3,3'-digallate affects the expression of TCAF2 mRNA

G

TEA domain transcription factor 4

affects expression

theaflavin-3,3'-digallate affects the expression of TEAD4 mRNA

NCBI chr 4:161,474,122...161,572,837
Ensembl chr 4:161,497,851...161,572,323

G

trans-2,3-enoyl-CoA reductase

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [LEP gene mutant form affects the expression of TECR mRNA]

NCBI chr19:24,526,700...24,568,168
Ensembl chr19:24,541,615...24,568,168

G

tectorin alpha

affects expression

theaflavin-3,3'-digallate affects the expression of TECTA mRNA

NCBI chr 8:42,707,962...42,779,726
Ensembl chr 8:42,707,962...42,779,707

G

TEF transcription factor, PAR bZIP family member

affects expression

theaflavin-3,3'-digallate affects the expression of TEF mRNA

NCBI chr 7:113,317,191...113,341,783
Ensembl chr 7:113,317,283...113,341,783

G

testis expressed 29

affects expression

theaflavin-3,3'-digallate affects the expression of TEX29 mRNA

NCBI chr16:77,650,471...77,664,171
Ensembl chr16:77,650,473...77,664,116

G

tolloid-like 2

affects expression

theaflavin-3,3'-digallate affects the expression of TLL2 mRNA

NCBI chr 1:239,912,648...240,028,168
Ensembl chr 1:239,915,508...240,028,120

G

toll-like receptor 9

affects expression

theaflavin-3,3'-digallate affects the expression of TLR9 mRNA

NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796

G

transmembrane 7 superfamily member 2

multiple interactions

theaflavin-3,3'-digallate inhibits the reaction [LEP gene mutant form affects the expression of TM7SF2 mRNA]

NCBI chr 1:203,355,930...203,360,287
Ensembl chr 1:203,355,931...203,360,270

G

transmembrane protein 119

affects expression

theaflavin-3,3'-digallate affects the expression of TMEM119 mRNA

NCBI chr12:42,828,621...42,835,678
Ensembl chr12:42,828,418...42,835,689

G

transmembrane protein 132E

affects expression

theaflavin-3,3'-digallate affects the expression of TMEM132E mRNA

NCBI chr10:67,330,863...67,386,790
Ensembl chr10:67,330,751...67,386,789

G

transmembrane protein 150B

affects expression

theaflavin-3,3'-digallate affects the expression of TMEM150B mRNA

NCBI chr 1:69,124,943...69,134,617
Ensembl chr 1:69,125,710...69,141,034

G

transmembrane protein 151A

affects expression

theaflavin-3,3'-digallate affects the expression of TMEM151A mRNA

NCBI chr 1:202,387,397...202,392,182
Ensembl chr 1:202,388,240...202,392,182

G

transmembrane protein 178B

affects expression

theaflavin-3,3'-digallate affects the expression of TMEM178B mRNA

NCBI chr 4:68,659,425...69,035,690
Ensembl chr 4:68,657,343...69,035,690

G

transmembrane protein 40

affects expression

theaflavin-3,3'-digallate affects the expression of TMEM40 mRNA

NCBI chr 4:148,791,509...148,819,287
Ensembl chr 4:148,791,505...148,823,665

G

transmembrane serine protease 7

affects expression

theaflavin-3,3'-digallate affects the expression of TMPRSS7 mRNA

NCBI chr11:55,127,992...55,166,597
Ensembl chr11:55,128,998...55,164,882

G

tumor necrosis factor

multiple interactions
decreases secretion
affects expression

theaflavin-3,3'-digallate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF mRNA]
theaflavin-3,3'-digallate results in decreased secretion of TNF protein
theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in increased expression of TNF mRNA]; theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in increased secretion of TNF protein]
theaflavin-3,3'-digallate affects the expression of TNF mRNA
theaflavin-3,3'-digallate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF mRNA]; theaflavin-3,3'-digallate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]; theaflavin-3,3'-digallate inhibits the reaction [TNF protein results in decreased expression of BGLAP protein]; theaflavin-3,3'-digallate inhibits the reaction [TNF protein results in decreased expression of CTNNB1 protein]; theaflavin-3,3'-digallate inhibits the reaction [TNF protein results in decreased expression of RUNX2 protein]; theaflavin-3,3'-digallate inhibits the reaction [TNF protein results in decreased expression of SP7 protein]; theaflavin-3,3'-digallate inhibits the reaction [TNF protein results in decreased phosphorylation of MAPK1 protein]; theaflavin-3,3'-digallate inhibits the reaction [TNF protein results in decreased phosphorylation of MAPK3 protein]; theaflavin-3,3'-digallate results in decreased expression of and results in decreased secretion of TNF protein

PMID:27871911 PMID:30874838 PMID:33833684 PMID:34925699 PMID:35847580 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 11A

affects expression

theaflavin-3,3'-digallate affects the expression of TNFRSF11A mRNA

NCBI chr13:21,928,370...21,986,719
Ensembl chr13:21,928,408...21,986,695

G

TNF superfamily member 11

multiple interactions

[theaflavin-3,3'-digallate results in increased expression of NFE2L2 protein] inhibits the reaction [TNFSF11 protein results in increased abundance of Reactive Oxygen Species]; theaflavin-3,3'-digallate inhibits the reaction [TNFSF11 protein results in decreased expression of CAT mRNA]; theaflavin-3,3'-digallate inhibits the reaction [TNFSF11 protein results in decreased expression of GPX1 mRNA]; theaflavin-3,3'-digallate inhibits the reaction [TNFSF11 protein results in decreased expression of HMOX1 mRNA]; theaflavin-3,3'-digallate inhibits the reaction [TNFSF11 protein results in decreased expression of NFE2L2 mRNA]; theaflavin-3,3'-digallate inhibits the reaction [TNFSF11 protein results in increased expression of CD40 mRNA]; theaflavin-3,3'-digallate inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; theaflavin-3,3'-digallate inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 mRNA]

NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445

G

TOG array regulator of axonemal microtubules 2

affects expression

theaflavin-3,3'-digallate affects the expression of TOGARAM2 mRNA

NCBI chr 6:23,770,979...23,828,884
Ensembl chr 6:23,771,052...23,828,499

G

trafficking regulator of GLUT4 (SLC2A4) 1

affects expression

theaflavin-3,3'-digallate affects the expression of TUSC5 mRNA

NCBI chr10:61,521,107...61,541,494
Ensembl chr10:61,521,107...61,541,494

G

triggering receptor expressed on myeloid cells 2

affects expression

theaflavin-3,3'-digallate affects the expression of TREM2 mRNA

NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170

G

tripartite motif-containing 31

affects expression

theaflavin-3,3'-digallate affects the expression of TRIM31 mRNA

NCBI chr20:1,653,165...1,666,494
Ensembl chr20:1,653,165...1,666,494

G

tripartite motif-containing 36

affects expression

theaflavin-3,3'-digallate affects the expression of TRIM36 mRNA

NCBI chr18:38,859,604...38,912,859
Ensembl chr18:38,861,018...38,912,859

G

tripartite motif containing 72

affects expression

theaflavin-3,3'-digallate affects the expression of TRIM72 mRNA

NCBI chr 1:182,613,753...182,621,613
Ensembl chr 1:182,613,712...182,621,606

G

transient receptor potential cation channel, subfamily M, member 6

affects expression

theaflavin-3,3'-digallate affects the expression of TRPM6 mRNA

NCBI chr 1:216,136,407...216,320,523
Ensembl chr 1:216,170,038...216,320,520

G

transient receptor potential cation channel, subfamily V, member 5

affects expression

theaflavin-3,3'-digallate affects the expression of TRPV5 mRNA

NCBI chr 4:70,536,432...70,562,743
Ensembl chr 4:70,536,440...70,562,745

G

translocator protein 2

affects expression

theaflavin-3,3'-digallate affects the expression of TSPO2 mRNA

NCBI chr 9:12,544,615...12,548,563
Ensembl chr 9:12,545,015...12,548,573

G

tetratricopeptide repeat domain 22

affects expression

theaflavin-3,3'-digallate affects the expression of TTC22 mRNA

NCBI chr 5:121,401,973...121,423,130
Ensembl chr 5:121,406,326...121,423,130

G

urotensin 2

affects expression

theaflavin-3,3'-digallate affects the expression of UTS2 mRNA

NCBI chr 5:161,450,846...161,456,235
Ensembl chr 5:161,450,846...161,456,237

G

vascular endothelial growth factor A

decreases secretion
multiple interactions

theaflavin-3,3'-digallate results in decreased secretion of VEGFA protein
[Methotrexate co-treated with theaflavin-3,3'-digallate] results in decreased secretion of VEGFA protein

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

villin 1

affects expression

theaflavin-3,3'-digallate affects the expression of VIL1 mRNA

NCBI chr 9:75,991,141...76,018,860
Ensembl chr 9:75,991,141...76,018,858

G

V-set and immunoglobulin domain containing 2

affects expression

theaflavin-3,3'-digallate affects the expression of VSIG2 mRNA

NCBI chr 8:37,250,107...37,255,150
Ensembl chr 8:37,250,107...37,255,150

G

visinin-like 1

affects expression

theaflavin-3,3'-digallate affects the expression of VSNL1 mRNA

NCBI chr 6:34,038,641...34,159,479
Ensembl chr 6:34,038,642...34,159,479

G

visual system homeobox 2

affects expression

theaflavin-3,3'-digallate affects the expression of VSX2 mRNA

NCBI chr 6:104,214,842...104,240,264
Ensembl chr 6:104,217,230...104,240,018

G

von Willebrand factor A domain containing 3A

affects expression

theaflavin-3,3'-digallate affects the expression of VWA3A mRNA

NCBI chr 1:175,293,782...175,355,588
Ensembl chr 1:175,293,873...175,355,602

G

WD repeat domain 38

affects expression

theaflavin-3,3'-digallate affects the expression of WDR38 mRNA

NCBI chr 3:22,750,150...22,753,260
Ensembl chr 3:22,749,396...22,753,259

G

WD repeat domain 86

affects expression

theaflavin-3,3'-digallate affects the expression of WDR86 mRNA

NCBI chr 4:10,423,496...10,443,473
Ensembl chr 4:10,424,008...10,441,465

G

Wnt family member 16

affects expression

theaflavin-3,3'-digallate affects the expression of WNT16 mRNA

NCBI chr 4:50,820,968...50,831,380
Ensembl chr 4:50,820,968...50,831,380

G

Wnt family member 6

affects expression

theaflavin-3,3'-digallate affects the expression of WNT6 mRNA

NCBI chr 9:76,329,882...76,343,523
Ensembl chr 9:76,329,882...76,343,523

G

Wnt family member 7A

affects expression

theaflavin-3,3'-digallate affects the expression of WNT7A mRNA

NCBI chr 4:123,863,108...123,908,981
Ensembl chr 4:123,863,108...123,908,981

G

WT1 transcription factor

affects expression

theaflavin-3,3'-digallate affects the expression of WT1 mRNA

NCBI chr 3:91,566,540...91,613,653
Ensembl chr 3:91,567,001...91,613,643

G

X-box binding protein 1

multiple interactions

[Methotrexate co-treated with theaflavin-3,3'-digallate] results in decreased expression of and results in decreased splicing of XBP1 mRNA; theaflavin-3,3'-digallate results in decreased expression of and results in decreased splicing of XBP1 mRNA

NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693

G

zygote arrest 1

affects expression

theaflavin-3,3'-digallate affects the expression of ZAR1 mRNA

NCBI chr14:35,193,446...35,197,382
Ensembl chr14:35,193,446...35,197,382

G

zygote arrest 1-like

affects expression

theaflavin-3,3'-digallate affects the expression of ZAR1L mRNA

NCBI chr12:46,534...56,434
Ensembl chr12:46,534...56,425

G

zinc finger protein 385C

affects expression

theaflavin-3,3'-digallate affects the expression of ZNF385C mRNA

NCBI chr10:85,562,003...85,618,100
Ensembl chr10:85,562,820...85,582,986

G

zinc finger FYVE-type containing 28

affects expression

theaflavin-3,3'-digallate affects the expression of ZFYVE28 mRNA

NCBI chr14:76,468,424...76,554,039
Ensembl chr14:76,468,424...76,554,039

G

zona pellucida glycoprotein 2

affects expression

theaflavin-3,3'-digallate affects the expression of ZP2 mRNA

NCBI chr 1:174,513,507...174,525,288
Ensembl chr 1:174,513,511...174,525,288

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19874
chemical entity	19872
molecular entity	19872
polyatomic entity	19824
heteroatomic molecular entity	19781
hydroxides	19341
organic hydroxy compound	18951
hydroxyflavan	3378
catechin	3357
Theaflavin 3,3'-digallate	514
Path 2
Term	Annotations
CHEBI ontology	19874
subatomic particle	19872
composite particle	19872
hadron	19872
baryon	19872
nucleon	19872
atomic nucleus	19872
atom	19872
main group element atom	19811
p-block element atom	19811
carbon group element atom	19751
carbon atom	19748
organic molecular entity	19748
organic molecule	19700
organic cyclic compound	19490
organic heterocyclic compound	18868
oxacycle	17903
benzopyran	11971
1-benzopyran	11725
flavonoid	7225
flavans	3639
hydroxyflavan	3378
catechin	3357
Theaflavin 3,3'-digallate	514

paths to the root