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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ethylisopropylamiloride
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Accession:CHEBI:136538 term browser browse the term
Definition:A member of the class of pyrazines that is amiloride in which the amino substitutent of the pyrazine ring that is adjacent to the chloro substituent has been substituted by an ethyl group and by an isopropyl group.
Synonyms:related_synonym: 3-amino-N-(aminoiminomethyl)-6-chloro-5-(ethyl(1-methylethyl)amino)pyrazinecarboxamide;   3-amino-N-carbamimidoyl-6-chloro-5-[ethyl(isopropyl)amino]pyrazine-2-carboxamide;   5-(N-ethyl-N-isopropyl)amiloride;   5-(ethylisopropyl)amiloride;   EIPA;   N-amidino-3-amino-5-ethylisopropylamino-6-chloropyrazine carboxamide;   ethyl isopropyl amiloride
 xref: CAS:1154-25-2
 xref_mesh: MESH:C039614
 xref: pubmed:10482815;   pubmed:12897821;   pubmed:15968466;   pubmed:20338684;   pubmed:23075671;   pubmed:23864606;   pubmed:25985899;   pubmed:26547075;   pubmed:9486355
 chemrof_formula: C11H18ClN7O
 chemrof_smiles: CCN(c1nc(N)c(C(=O)NC(=N)N)nc1Cl)C(C)C
 chemrof_inchi: InChI=1S/C11H18ClN7O/c1-4-19(5(2)3)9-7(12)16-6(8(13)17-9)10(20)18-11(14)15/h5H,4H2,1-3H3,(H2,13,17)(H4,14,15,18,20)
 chemrof_inchikey: QDERNBXNXJCIQK-UHFFFAOYSA-N
 cyclic_relationship: has_functional_parent CHEBI:2639


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ethylisopropylamiloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin decreases uptake ISO ethylisopropylamiloride results in decreased uptake of ALB protein CTD PMID:16313995 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865 		JBrowse link
G Aoc1 amine oxidase, copper containing 1 affects binding
multiple interactions
decreases activity 		ISO
EXP 		ethylisopropylamiloride binds to AOC1 protein
ethylisopropylamiloride inhibits the reaction [AOC1 protein results in increased degradation of Putrescine]
ethylisopropylamiloride results in decreased activity of AOC1 protein
Ethylisopropylamiloride inhibits the reaction [Phenylamil binds to Aoc1 protein]
Ethylisopropylamiloride binds to Aoc1 protein 		CTD
RGD		 PMID:2217167 PMID:8144586 PMID:8375402 PMID:8375402 RGD:724757, RGD:724757 NCBI chr 4:79,143,126...79,162,705
Ensembl chr 4:79,143,126...79,162,704 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO ethylisopropylamiloride inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 protein] CTD PMID:12107048 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP ethylisopropylamiloride inhibits the reaction [ferric nitrilotriacetate results in increased expression of COL1A1 protein]; ethylisopropylamiloride inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of COL1A1 protein] CTD PMID:11159895 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO ethylisopropylamiloride results in decreased activity of CYP1A1 protein CTD PMID:15081870 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO ethylisopropylamiloride results in decreased activity of CYP1A2 protein CTD PMID:15081870 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO ethylisopropylamiloride results in decreased activity of CYP1B1 protein CTD PMID:15081870 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142 		JBrowse link
G Fah fumarylacetoacetate hydrolase affects splicing ISO ethylisopropylamiloride affects the splicing of FAH mutant form CTD PMID:23895425 NCBI chr 1:147,957,931...147,980,708
Ensembl chr 1:147,957,935...147,981,046 		JBrowse link
G Ifng interferon gamma multiple interactions ISO ethylisopropylamiloride inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with IFNG protein] results in increased secretion of IL12B protein] CTD PMID:11420121 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO ethylisopropylamiloride inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with IFNG protein] results in increased secretion of IL12B protein] CTD PMID:11420121 NCBI chr10:29,390,300...29,405,194
Ensembl chr10:29,389,905...29,405,194 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO ethylisopropylamiloride inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein] CTD PMID:12065299 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO ethylisopropylamiloride inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of NFKB1 protein] CTD PMID:12107048 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO ethylisopropylamiloride inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:17237260 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO ethylisopropylamiloride inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of RELA protein] CTD PMID:12107048 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Slc9a1 solute carrier family 9 member A1 decreases activity
multiple interactions 		ISO
EXP 		ethylisopropylamiloride results in decreased activity of SLC9A1 protein
[ethylisopropylamiloride results in decreased activity of SLC9A1 protein] which results in increased abundance of Doxorubicin 		CTD PMID:12562776 PMID:15729714 PMID:17552965 NCBI chr 5:150,859,412...150,913,525
Ensembl chr 5:150,860,228...150,913,517 		JBrowse link
G Srsf3 serine and arginine rich splicing factor 3 increases expression ISO ethylisopropylamiloride results in increased expression of SRSF3 protein CTD PMID:17924536 NCBI chr20:7,093,529...7,103,517
Ensembl chr20:7,093,565...7,103,516 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO ethylisopropylamiloride results in decreased expression of VEGFA mRNA; ethylisopropylamiloride results in decreased expression of VEGFA protein CTD PMID:16884771 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      chemical role 20219
        acceptor 17380
          Bronsted base 17175
            organic amino compound 17164
              aromatic amine 11708
                ethylisopropylamiloride 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            organic molecule 20499
                              organic cyclic compound 20390
                                organic heterocyclic compound 19381
                                  organic heteromonocyclic compound 18004
                                    diazines 13662
                                      pyrazines 1113
                                        ethylisopropylamiloride 17
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