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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:VX nerve agent
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Accession:CHEBI:136185 term browser browse the term
Definition:A organic thiophosphate that is the ethyl ester of S-{2-[di(propan-2-yl)amino]ethyl} O hydrogen methylphosphonothioate. A toxic nerve agent used in chemical warfare.
Synonyms:exact_synonym: S-{2-[di(propan-2-yl)amino]ethyl} O-ethyl methylphosphonothioate
 related_synonym: Ethyl S-2-diisopropylaminoethyl methylphosphonothiolate;   Ethyl-S-diisopropylaminoethyl methylthiophosphonate;   Formula=C11H26NO2PS;   InChI=1S/C11H26NO2PS/c1-7-14-15(6,13)16-9-8-12(10(2)3)11(4)5/h10-11H,7-9H2,1-6H3;   InChIKey=JJIUCEJQJXNMHV-UHFFFAOYSA-N;   O-Ethyl S-(2-diisopropylaminoethyl) methylphosphonothioate;   O-ethyl-S-[2-(N,N-diisopropylamino)ethyl] ester;   S-(2-Diisopropylaminoethyl) O-ethyl methyl phosphonothiolate;   SMILES=CC(N(CCSP(OCC)(=O)C)C(C)C)C;   VX
 xref: CAS:50782-69-9;   Chemspider:36386
 xref_mesh: MESH:C009680
 xref: PMID:20947456;   PMID:21862421;   PMID:21905719;   PMID:22042427;   PMID:23083335;   PMID:23126561;   PMID:23402290;   PMID:23872337;   PMID:24517492;   PMID:24633585;   PMID:24766293;   PMID:24854058;   PMID:24972874;   PMID:26327407;   PMID:26561750;   PMID:27113675;   PMID:27594690;   PMID:27627873;   PMID:28098192;   PMID:28179194;   PMID:28267914;   Reaxys:1949015;   Wikipedia:VX_(nerve_agent)


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VX nerve agent term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase multiple interactions
decreases activity		 EXP [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [VX results in decreased activity of ACHE protein] CTD PMID:16915560 NCBI chr 6:8,874,747...8,879,926
Ensembl chr 6:8,873,584...8,879,702 		JBrowse link
G BCHE butyrylcholinesterase decreases activity EXP VX results in decreased activity of BCHE protein CTD PMID:16915560 NCBI chr34:30,912,632...30,977,624
Ensembl chr34:30,912,632...30,977,583 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 498
    role 498
      biological role 498
        aetiopathogenetic role 394
          neurotoxin 358
            VX nerve agent 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 498
    subatomic particle 498
      composite particle 498
        hadron 498
          baryon 498
            nucleon 498
              atomic nucleus 498
                atom 498
                  main group element atom 491
                    p-block element atom 491
                      chalcogen 447
                        oxygen atom 445
                          oxygen molecular entity 445
                            hydroxides 420
                              oxoacid 375
                                pnictogen oxoacid 14
                                  phosphorus oxoacid 9
                                    phosphoric acids 9
                                      phosphoric acid 9
                                        phosphoric acid derivative 8
                                          phosphate 8
                                            organic phosphate 8
                                              organic thiophosphate 2
                                                VX nerve agent 2
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