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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:linsidomine
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Accession:CHEBI:136004 term browser browse the term
Synonyms:related_synonym: Formula=C6H10N4O2;   InChI=1S/C6H10N4O2/c7-6-5-10(8-12-6)9-1-3-11-4-2-9/h5,7H,1-4H2;   InChIKey=FKDHHVKWGRFRTG-UHFFFAOYSA-N;   SMILES=C1CN(CCO1)[N+]2=CC(O[N-]2)=N;   linsidomine HCl;   linsidomine hydrochloride
 xref: CAS:33876-97-0;   Drug_Central:4589
 xref_mesh: MESH:C002385



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linsidomine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca5 ATP binding cassette subfamily A member 5 increases oxidation EXP linsidomine results in increased oxidation of ABCA5 protein CTD PMID:28086193 NCBI chr10:95,739,610...95,808,633
Ensembl chr10:95,240,154...95,308,976
JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant increases oxidation EXP linsidomine results in increased oxidation of ACP5 protein CTD PMID:28086193 NCBI chr 8:28,939,984...28,946,639
Ensembl chr 8:20,663,985...20,667,929
JBrowse link
G Agrn agrin increases oxidation EXP linsidomine results in increased oxidation of AGRN protein CTD PMID:28086193 NCBI chr 5:172,031,528...172,064,429
Ensembl chr 5:166,749,310...166,786,003
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases metabolic processing
multiple interactions
increases phosphorylation
ISO
EXP
linsidomine results in increased metabolism of AKT1 protein
linsidomine inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]
wortmannin inhibits the reaction [linsidomine results in increased phosphorylation of AKT1 protein]
CTD PMID:17302912 PMID:19682478 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Anxa2 annexin A2 decreases expression EXP linsidomine results in decreased expression of ANXA2 protein CTD PMID:21204247 NCBI chr 8:78,986,252...79,022,638
Ensembl chr 8:70,105,253...70,141,658
JBrowse link
G Ap2a2 adaptor related protein complex 2 subunit alpha 2 increases oxidation EXP linsidomine results in increased oxidation of AP2A2 protein CTD PMID:28086193 NCBI chr 1:196,652,315...196,725,609
Ensembl chr 1:196,652,337...196,725,603
JBrowse link
G Apba1 amyloid beta precursor protein binding family A member 1 increases oxidation EXP linsidomine results in increased oxidation of APBA1 protein CTD PMID:28086193 NCBI chr 1:230,790,297...230,995,986
Ensembl chr 1:221,363,778...221,566,553
JBrowse link
G Apob apolipoprotein B increases oxidation EXP linsidomine results in increased oxidation of APOB protein CTD PMID:28086193 NCBI chr 6:36,563,704...36,603,300
Ensembl chr 6:30,844,368...30,892,497
JBrowse link
G Arnt2 aryl hydrocarbon receptor nuclear translocator 2 increases oxidation EXP linsidomine results in increased oxidation of ARNT2 protein CTD PMID:28086193 NCBI chr 1:147,645,354...147,801,986
Ensembl chr 1:138,189,940...138,393,153
JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO linsidomine results in increased expression of ATF4 mRNA CTD PMID:21703327 NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Avp arginine vasopressin increases expression EXP linsidomine results in increased expression of AVP mRNA CTD PMID:10460269 NCBI chr 3:138,246,544...138,248,522
Ensembl chr 3:117,793,457...117,795,425
JBrowse link
G Avpr1b arginine vasopressin receptor 1B increases oxidation EXP linsidomine results in increased oxidation of AVPR1B protein CTD PMID:28086193 NCBI chr13:45,598,116...45,611,680
Ensembl chr13:43,046,267...43,057,792
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO linsidomine results in increased expression of BAX
MT1A inhibits the reaction [linsidomine results in increased expression of BAX]
linsidomine results in increased expression of BAX protein
Selegiline inhibits the reaction [linsidomine results in increased expression of BAX protein]
CTD PMID:12880480 PMID:16291239 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO linsidomine results in decreased expression of BCL2; linsidomine results in decreased expression of BCL2 protein
MT1A inhibits the reaction [linsidomine results in decreased expression of BCL2]; Plant Extracts inhibits the reaction [linsidomine results in decreased expression of BCL2 protein]
[linsidomine results in increased abundance of Nitric Oxide] which results in increased expression of BCL2 mRNA; [linsidomine results in increased abundance of Nitric Oxide] which results in increased expression of BCL2 protein; Selegiline inhibits the reaction [linsidomine results in decreased expression of BCL2 protein]
CTD PMID:7706495 PMID:12880480 PMID:16291239 PMID:23174672 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Brca2 BRCA2, DNA repair associated increases oxidation EXP linsidomine results in increased oxidation of BRCA2 protein CTD PMID:28086193 NCBI chr12:4,895,092...4,939,340
Ensembl chr12:59,819...100,567
JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C multiple interactions ISO [linsidomine co-treated with Peroxynitrous Acid] results in increased nitrosation of CACNA1C protein CTD PMID:17551092 NCBI chr 4:153,431,169...154,051,932
Ensembl chr 4:151,764,138...152,379,648
JBrowse link
G Cacna1e calcium voltage-gated channel subunit alpha1 E increases oxidation EXP linsidomine results in increased oxidation of CACNA1E protein CTD PMID:28086193 NCBI chr13:69,125,048...69,613,795
Ensembl chr13:66,581,920...66,894,450
JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H increases oxidation EXP linsidomine results in increased oxidation of CACNA1H protein CTD PMID:28086193 NCBI chr10:14,894,630...14,952,317
Ensembl chr10:14,390,113...14,448,376
JBrowse link
G Cacnb2 calcium voltage-gated channel auxiliary subunit beta 2 increases oxidation EXP linsidomine results in increased oxidation of CACNB2 protein CTD PMID:28086193 NCBI chr17:82,473,097...82,818,564
Ensembl chr17:77,564,460...77,909,106
JBrowse link
G Calca calcitonin-related polypeptide alpha increases response to substance EXP CALCA protein results in increased susceptibility to linsidomine CTD PMID:8581270 NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Carm1 coactivator-associated arginine methyltransferase 1 increases oxidation EXP linsidomine results in increased oxidation of CARM1 protein CTD PMID:28086193 NCBI chr 8:28,373,370...28,418,056
Ensembl chr 8:20,097,254...20,147,689
JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage
increases expression
multiple interactions
ISO
EXP
linsidomine results in increased activity of CASP3 protein
linsidomine results in increased cleavage of CASP3 protein
linsidomine results in increased expression of CASP3 mRNA; linsidomine results in increased expression of CASP3 protein; linsidomine results in increased expression of CASP3 protein modified form
Melatonin inhibits the reaction [linsidomine results in increased expression of CASP3 mRNA]; MT1A inhibits the reaction [linsidomine results in increased activity of CASP3 protein]; Plant Extracts inhibits the reaction [linsidomine results in increased cleavage of CASP3 protein]; Plant Extracts inhibits the reaction [linsidomine results in increased expression of CASP3 protein modified form]; Selegiline inhibits the reaction [linsidomine results in increased expression of CASP3 mRNA]; Selegiline inhibits the reaction [linsidomine results in increased expression of CASP3 protein]; Ubiquinone inhibits the reaction [linsidomine results in increased expression of CASP3 mRNA]
CTD PMID:12880480 PMID:15686499 PMID:16291239 PMID:19038279 PMID:23174672 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase multiple interactions ISO linsidomine results in decreased activity of and results in decreased expression of CAT protein; Plant Extracts inhibits the reaction [linsidomine results in decreased activity of and results in decreased expression of CAT protein]
CAT protein inhibits the reaction [linsidomine results in decreased expression of CCND1 mRNA]; CAT protein inhibits the reaction [linsidomine results in decreased expression of CCND1 protein]
CTD PMID:12600834 PMID:23174672 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO CAT protein inhibits the reaction [linsidomine results in decreased expression of CCND1 mRNA]; CAT protein inhibits the reaction [linsidomine results in decreased expression of CCND1 protein]
linsidomine results in decreased expression of CCND1 mRNA; linsidomine results in decreased expression of CCND1 protein
CTD PMID:12600834 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cep83 centrosomal protein 83 increases oxidation EXP linsidomine results in increased oxidation of CEP83 protein CTD PMID:28086193 NCBI chr 7:29,280,358...29,389,574
Ensembl chr 7:29,280,419...29,389,574
JBrowse link
G Cep95 centrosomal protein 95 increases oxidation EXP linsidomine results in increased oxidation of CEP95 protein CTD PMID:28086193 NCBI chr10:92,231,829...92,259,813
Ensembl chr10:91,732,111...91,760,092
JBrowse link
G Cldn5 claudin 5 decreases expression ISO linsidomine results in decreased expression of CLDN5 protein CTD PMID:34391839 NCBI chr11:95,717,172...95,718,598
Ensembl chr11:82,211,475...82,214,992
JBrowse link
G Clrn1 clarin 1 increases oxidation EXP linsidomine results in increased oxidation of CLRN1 protein CTD PMID:28086193 NCBI chr 2:143,084,030...143,130,948
Ensembl chr 2:143,084,030...143,130,948
JBrowse link
G Clu clusterin increases oxidation EXP linsidomine results in increased oxidation of CLU protein CTD PMID:28086193 NCBI chr15:44,336,619...44,375,861
Ensembl chr15:40,174,617...40,200,315
JBrowse link
G Crh corticotropin releasing hormone multiple interactions
increases expression
EXP CRH protein affects the reaction [linsidomine results in increased secretion of POMC protein alternative form]
linsidomine results in increased expression of CRH mRNA
CTD PMID:10460269 NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:102,143,055...102,144,919
JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 increases expression EXP linsidomine results in increased expression of CRHR1 mRNA CTD PMID:10460269 NCBI chr10:89,540,192...89,583,466
Ensembl chr10:89,040,203...89,083,481
JBrowse link
G Cttnbp2 cortactin binding protein 2 increases oxidation EXP linsidomine results in increased oxidation of CTTNBP2 protein CTD PMID:28086193 NCBI chr 4:47,766,867...47,930,598
Ensembl chr 4:46,800,981...46,964,631
JBrowse link
G Cycs cytochrome c, somatic affects localization
multiple interactions
ISO linsidomine affects the localization of CYCS protein
Selegiline inhibits the reaction [linsidomine affects the localization of CYCS protein]
CTD PMID:12880480 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO linsidomine results in increased expression of DDIT3 mRNA CTD PMID:21703327 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Ddx52 DExD-box helicase 52 increases oxidation EXP linsidomine results in increased oxidation of DDX52 protein CTD PMID:28086193 NCBI chr10:68,824,594...68,847,400
Ensembl chr10:68,824,645...68,848,266
JBrowse link
G Dlgap4 DLG associated protein 4 increases oxidation EXP linsidomine results in increased oxidation of DLGAP4 protein CTD PMID:28086193 NCBI chr 3:145,124,189...145,271,791
Ensembl chr 3:145,175,479...145,270,490
JBrowse link
G Dnah7 dynein, axonemal, heavy chain 7 increases oxidation EXP linsidomine results in increased oxidation of DNAH7 protein CTD PMID:28086193 NCBI chr 9:62,454,838...62,760,504
Ensembl chr 9:54,960,440...55,262,297
JBrowse link
G Dnmt1 DNA methyltransferase 1 increases oxidation EXP linsidomine results in increased oxidation of DNMT1 protein CTD PMID:28086193 NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:19,440,611...19,486,659
JBrowse link
G Dscam DS cell adhesion molecule increases oxidation EXP linsidomine results in increased oxidation of DSCAM protein CTD PMID:28086193 NCBI chr11:35,921,924...36,507,100
Ensembl chr11:35,926,896...36,507,415
JBrowse link
G E2f2 E2F transcription factor 2 decreases activity ISO linsidomine results in decreased activity of E2F2 protein CTD PMID:12600834 NCBI chr 5:153,682,789...153,706,087
Ensembl chr 5:148,399,642...148,421,217
JBrowse link
G Eaf2 ELL associated factor 2 increases oxidation EXP linsidomine results in increased oxidation of EAF2 protein CTD PMID:28086193 NCBI chr11:77,465,585...77,509,993
Ensembl chr11:63,960,200...64,004,610
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases phosphorylation ISO linsidomine results in increased phosphorylation of EIF2AK3 protein CTD PMID:21703327 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation ISO linsidomine results in increased phosphorylation of EIF2S1 protein CTD PMID:21703327 NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Ephx2 epoxide hydrolase 2 increases oxidation EXP linsidomine results in increased oxidation of EPHX2 protein CTD PMID:28086193 NCBI chr15:44,465,447...44,503,157
Ensembl chr15:40,289,902...40,327,615
JBrowse link
G Evl Enah/Vasp-like increases oxidation EXP linsidomine results in increased oxidation of EVL protein CTD PMID:28086193 NCBI chr 6:133,238,547...133,358,730
Ensembl chr 6:127,474,543...127,594,344
JBrowse link
G Fam221b family with sequence similarity 221, member B increases oxidation EXP linsidomine results in increased oxidation of FAM221B protein CTD PMID:28086193 NCBI chr 5:57,910,346...57,919,562
Ensembl chr 5:57,910,352...57,919,367
JBrowse link
G Faslg Fas ligand multiple interactions ISO [linsidomine results in increased abundance of Nitric Oxide] inhibits the reaction [Etoposide results in increased activity of FASLG promoter]; [linsidomine results in increased abundance of Nitric Oxide] inhibits the reaction [N-caproylsphingosine results in increased activity of FASLG promoter] CTD PMID:10811113 NCBI chr13:76,680,885...76,706,042
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fasn fatty acid synthase increases oxidation EXP linsidomine results in increased oxidation of FASN protein CTD PMID:28086193 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fra10ac1 FRA10A associated CGG repeat 1 increases oxidation EXP linsidomine results in increased oxidation of FRA10AC1 protein CTD PMID:28086193 NCBI chr 1:235,969,071...236,001,074
Ensembl chr 1:235,969,112...236,001,210
JBrowse link
G Gabra5 gamma-aminobutyric acid type A receptor subunit alpha 5 increases oxidation EXP linsidomine results in increased oxidation of GABRA5 protein CTD PMID:28086193 NCBI chr 1:117,404,446...117,517,424
Ensembl chr 1:108,268,776...108,380,917
JBrowse link
G Glg1 golgi glycoprotein 1 increases oxidation EXP linsidomine results in increased oxidation of GLG1 protein CTD PMID:28086193 NCBI chr19:56,034,248...56,133,538
Ensembl chr19:39,124,641...39,224,178
JBrowse link
G Golga4 golgin A4 increases oxidation EXP linsidomine results in increased oxidation of GOLGA4 protein CTD PMID:28086193 NCBI chr 8:118,208,200...118,285,003 JBrowse link
G Grm7 glutamate metabotropic receptor 7 increases oxidation EXP linsidomine results in increased oxidation of GRM7 protein CTD PMID:28086193 NCBI chr 4:143,730,862...144,613,230
Ensembl chr 4:143,731,259...144,612,344
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression EXP linsidomine results in increased expression of GSTA2; linsidomine results in increased expression of GSTA2 protein CTD PMID:12446173 PMID:15357004 NCBI chr 8:88,064,829...88,077,168
Ensembl chr 8:79,184,322...79,196,798
JBrowse link
G Gucy2e guanylate cyclase 2E increases oxidation EXP linsidomine results in increased oxidation of GUCY2E protein CTD PMID:28086193 NCBI chr10:54,453,753...54,478,639
Ensembl chr10:53,959,010...53,974,067
JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha increases oxidation EXP linsidomine results in increased oxidation of HADHA protein CTD PMID:28086193 NCBI chr 6:31,907,801...31,947,434
Ensembl chr 6:26,187,956...26,227,869
JBrowse link
G Hgs hepatocyte growth factor-regulated tyrosine kinase substrate increases oxidation EXP linsidomine results in increased oxidation of HGS protein CTD PMID:28086193 NCBI chr10:105,739,617...105,757,838
Ensembl chr10:105,739,296...105,757,835
JBrowse link
G Hist1h2bg histone cluster 1, H2bg increases oxidation EXP linsidomine results in increased oxidation of HIST1H2BG protein CTD PMID:28086193 NCBI chr17:41,999,269...42,000,237
Ensembl chr17:41,571,210...41,571,896
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO [linsidomine co-treated with Nitroprusside] results in increased expression of HMOX1 mRNA; [linsidomine co-treated with S-Nitrosoglutathione] results in increased expression of HMOX1 mRNA
linsidomine results in increased expression of HMOX1 mRNA
CTD PMID:8764571 PMID:10423162 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hnrnpm heterogeneous nuclear ribonucleoprotein M increases oxidation EXP linsidomine results in increased oxidation of HNRNPM protein CTD PMID:28086193 NCBI chr 7:15,140,877...15,178,871
Ensembl chr 7:14,438,688...14,476,762
JBrowse link
G Hormad1 HORMA domain containing 1 increases oxidation EXP linsidomine results in increased oxidation of HORMAD1 protein CTD PMID:28086193 NCBI chr 2:185,803,572...185,841,449
Ensembl chr 2:183,116,716...183,152,383
JBrowse link
G Il6 interleukin 6 multiple interactions
increases secretion
ISO TLR4 gene mutant form inhibits the reaction [linsidomine results in increased secretion of IL6 protein] CTD PMID:29175419 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ilk integrin-linked kinase increases oxidation EXP linsidomine results in increased oxidation of ILK protein CTD PMID:28086193 NCBI chr 1:169,500,716...169,506,972
Ensembl chr 1:160,088,897...160,095,140
JBrowse link
G Ins1 insulin 1 multiple interactions ISO linsidomine inhibits the reaction [INS1 protein binds to PIK3R1 protein]; linsidomine inhibits the reaction [INS1 protein results in increased activity of PIK3R1 protein]; linsidomine inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]; linsidomine inhibits the reaction [INS1 protein results in increased phosphorylation of INSR protein]; linsidomine inhibits the reaction [INS1 protein results in increased phosphorylation of IRS1 protein] CTD PMID:19682478 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:251,244,973...251,245,536
JBrowse link
G Insr insulin receptor multiple interactions
increases metabolic processing
ISO linsidomine inhibits the reaction [INS1 protein results in increased phosphorylation of INSR protein]
linsidomine results in increased metabolism of INSR protein
CTD PMID:19682478 NCBI chr12:5,991,135...6,129,275
Ensembl chr12:1,197,100...1,330,883
JBrowse link
G Iqsec3 IQ motif and Sec7 domain ArfGEF 3 increases oxidation EXP linsidomine results in increased oxidation of IQSEC3 protein CTD PMID:28086193 NCBI chr 4:156,283,040...156,379,396
Ensembl chr 4:154,610,934...154,707,310
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO linsidomine inhibits the reaction [INS1 protein results in increased phosphorylation of IRS1 protein]; linsidomine results in increased metabolism of and results in decreased expression of IRS1 protein CTD PMID:19682478 NCBI chr 9:91,001,137...91,053,959
Ensembl chr 9:83,548,944...83,606,122
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 multiple interactions
increases expression
ISO Cycloheximide inhibits the reaction [linsidomine results in increased expression of ITPR1 mRNA]; Dactinomycin inhibits the reaction [linsidomine results in increased expression of ITPR1 mRNA] CTD PMID:17241155 NCBI chr 4:142,743,401...143,066,505
Ensembl chr 4:141,187,418...141,510,491
JBrowse link
G Itpr3 inositol 1,4,5-trisphosphate receptor, type 3 increases oxidation EXP linsidomine results in increased oxidation of ITPR3 protein CTD PMID:28086193 NCBI chr20:5,138,553...5,204,189
Ensembl chr20:5,136,441...5,202,337
JBrowse link
G Kat6a lysine acetyltransferase 6A increases oxidation EXP linsidomine results in increased oxidation of KAT6A protein CTD PMID:28086193 NCBI chr16:75,787,411...75,868,584
Ensembl chr16:69,084,914...69,163,606
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 affects response to substance ISO KEAP1 mRNA affects the susceptibility to linsidomine CTD PMID:16092930 NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Khdrbs2 KH RNA binding domain containing, signal transduction associated 2 increases oxidation EXP linsidomine results in increased oxidation of KHDRBS2 protein CTD PMID:28086193 NCBI chr 9:41,943,029...42,449,687
Ensembl chr 9:34,447,056...34,915,530
JBrowse link
G Klk8 kallikrein related-peptidase 8 increases oxidation EXP linsidomine results in increased oxidation of KLK8 protein CTD PMID:28086193 NCBI chr 1:103,388,352...103,395,195
Ensembl chr 1:94,251,803...94,258,646
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation
ISO bosutinib affects the reaction [linsidomine results in increased phosphorylation of MAPK8 protein] CTD PMID:34519134 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mprip myosin phosphatase Rho interacting protein increases oxidation EXP linsidomine results in increased oxidation of MPRIP protein CTD PMID:28086193 NCBI chr10:44,953,472...45,073,388
Ensembl chr10:44,453,929...44,569,118
JBrowse link
G Mt1 metallothionein 1 multiple interactions
decreases response to substance
increases expression
ISO MT1A inhibits the reaction [linsidomine results in decreased expression of BCL2]; MT1A inhibits the reaction [linsidomine results in increased activity of CASP3 protein]; MT1A inhibits the reaction [linsidomine results in increased expression of BAX]
MT1 protein results in decreased susceptibility to linsidomine
linsidomine results in increased expression of MT1 protein
Selegiline inhibits the reaction [linsidomine results in increased expression of MT1 protein]
CTD PMID:12880480 PMID:16291239 NCBI chr19:10,831,959...10,832,975
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr  X:10,826,032...10,827,049
JBrowse link
G Mtfr1 mitochondrial fission regulator 1 increases oxidation EXP linsidomine results in increased oxidation of MTFR1 protein CTD PMID:28086193 NCBI chr 2:103,594,458...103,629,697
Ensembl chr 2:101,679,265...101,713,544
JBrowse link
G Mtor mechanistic target of rapamycin kinase increases oxidation EXP linsidomine results in increased oxidation of MTOR protein CTD PMID:28086193 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Mybpc3 myosin binding protein C3 increases oxidation EXP linsidomine results in increased oxidation of MYBPC3 protein CTD PMID:28086193 NCBI chr 3:97,550,974...97,569,216
Ensembl chr 3:77,095,252...77,113,405
JBrowse link
G Nat1 N-acetyltransferase 1 decreases activity ISO linsidomine results in decreased activity of NAT1 protein CTD PMID:14672957 NCBI chr16:26,984,882...27,005,194
Ensembl chr16:22,208,194...22,238,520
JBrowse link
G Nbr1 NBR1, autophagy cargo receptor increases oxidation EXP linsidomine results in increased oxidation of NBR1 protein CTD PMID:28086193 NCBI chr10:86,978,024...87,006,664
Ensembl chr10:86,478,290...86,506,412
JBrowse link
G Nf1 neurofibromin 1 increases oxidation EXP linsidomine results in increased oxidation of NF1 protein CTD PMID:28086193 NCBI chr10:64,803,986...65,037,086
Ensembl chr10:64,306,301...64,536,658
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
decreases response to substance
ISO
EXP
[linsidomine results in increased expression of NFE2L2 protein] which results in decreased susceptibility to Oxidopamine
NFE2L2 protein results in decreased susceptibility to linsidomine
1,2-dithiol-3-thione promotes the reaction [NFE2L2 results in decreased susceptibility to linsidomine]
linsidomine results in increased localization of and results in increased activity of NFE2L2 protein
CTD PMID:12446173 PMID:16092930 PMID:18367636 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nos1 nitric oxide synthase 1 increases expression
increases oxidation
EXP linsidomine results in increased expression of NOS1 mRNA
linsidomine results in increased oxidation of NOS1 protein
CTD PMID:19038279 PMID:28086193 NCBI chr12:44,276,011...44,456,371
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
ISO linsidomine results in increased expression of NOS2 protein
[linsidomine results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitrites; [Plant Extracts inhibits the reaction [linsidomine results in increased expression of NOS2 protein]] which results in decreased chemical synthesis of Nitrites; Plant Extracts inhibits the reaction [linsidomine results in increased expression of NOS2 protein]
CTD PMID:23174672 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression EXP linsidomine results in increased expression of NR4A1 mRNA CTD PMID:10460269 NCBI chr 7:134,247,153...134,268,044
Ensembl chr 7:132,374,840...132,389,297
JBrowse link
G Oma1 OMA1 zinc metallopeptidase increases oxidation EXP linsidomine results in increased oxidation of OMA1 protein CTD PMID:28086193 NCBI chr 5:118,083,728...118,136,980
Ensembl chr 5:118,083,728...118,136,980
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
decreases expression
decreases folding
decreases activity
increases cleavage
ISO Selegiline inhibits the reaction [linsidomine results in decreased expression of PARP1 protein]
linsidomine results in decreased folding of PARP1 protein
[bosutinib co-treated with linsidomine] affects the expression of PARP1 protein; bosutinib affects the reaction [linsidomine results in increased cleavage of PARP1 protein]; linsidomine inhibits the reaction [PARP1 protein binds to Zinc]; linsidomine results in decreased activity of and results in increased nitrosation of PARP1 protein
linsidomine results in decreased activity of PARP1 protein
CTD PMID:12880480 PMID:31152818 PMID:34519134 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO linsidomine results in decreased expression of PCNA protein CTD PMID:12600834 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pds5a PDS5 cohesin associated factor A increases oxidation EXP linsidomine results in increased oxidation of PDS5A protein CTD PMID:28086193 NCBI chr14:42,905,734...43,004,740
Ensembl chr14:42,552,647...42,648,669
JBrowse link
G Pepd peptidase D multiple interactions ISO linsidomine results in increased phosphorylation of and results in increased activity of PEPD protein CTD PMID:16167338 NCBI chr 1:87,536,650...87,681,233
Ensembl chr 1:87,536,609...87,681,231
JBrowse link
G Per2 period circadian regulator 2 decreases response to substance ISO PER2 protein mutant form results in decreased susceptibility to linsidomine CTD PMID:25628599 NCBI chr 9:99,454,828...99,497,069
Ensembl chr 9:92,007,296...92,049,459
JBrowse link
G Pi4ka phosphatidylinositol 4-kinase alpha increases oxidation EXP linsidomine results in increased oxidation of PI4KA protein CTD PMID:28086193 NCBI chr11:83,609,148...83,726,876
Ensembl chr11:83,609,069...83,724,080
JBrowse link
G Pif1 PIF1 5'-to-3' DNA helicase increases oxidation EXP linsidomine results in increased oxidation of PIF1 protein CTD PMID:28086193 NCBI chr 8:75,005,820...75,015,331
Ensembl chr 8:66,111,072...66,120,200
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions ISO linsidomine inhibits the reaction [INS1 protein binds to PIK3R1 protein]; linsidomine inhibits the reaction [INS1 protein results in increased activity of PIK3R1 protein] CTD PMID:19682478 NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:32,882,032...32,963,631
JBrowse link
G Plb1 phospholipase B1 increases oxidation EXP linsidomine results in increased oxidation of PLB1 protein CTD PMID:28086193 NCBI chr 6:29,807,127...29,945,607
Ensembl chr 6:24,089,214...24,210,117
JBrowse link
G Plekhg5 pleckstrin homology and RhoGEF domain containing G5 increases oxidation EXP linsidomine results in increased oxidation of PLEKHG5 protein CTD PMID:28086193 NCBI chr 5:162,577,999...162,621,518
Ensembl chr 5:162,578,071...162,621,513
JBrowse link
G Pomc proopiomelanocortin multiple interactions
increases secretion
EXP CRH protein affects the reaction [linsidomine results in increased secretion of POMC protein alternative form] CTD PMID:10460269 NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Ppp1r37 protein phosphatase 1, regulatory subunit 37 increases oxidation EXP linsidomine results in increased oxidation of PPP1R37 protein CTD PMID:28086193 NCBI chr 1:88,308,782...88,340,796
Ensembl chr 1:79,180,793...79,212,612
JBrowse link
G Prkca protein kinase C, alpha multiple interactions EXP [linsidomine co-treated with Staurosporine] results in decreased expression of PRKCA protein; Staurosporine inhibits the reaction [linsidomine results in increased phosphorylation of PRKCA protein] CTD PMID:11994256 NCBI chr10:93,388,991...93,787,617
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase increases expression
multiple interactions
ISO linsidomine results in increased expression of PRKN protein
Selegiline inhibits the reaction [linsidomine results in increased expression of PRKN protein]
CTD PMID:12880480 NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:48,690,556...49,882,555
JBrowse link
G Pten phosphatase and tensin homolog increases oxidation EXP linsidomine results in increased oxidation of PTEN protein CTD PMID:17302912 NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Rab29 RAB29, member RAS oncogene family increases oxidation EXP linsidomine results in increased oxidation of RAB29 protein CTD PMID:28086193 NCBI chr13:45,859,930...45,865,468
Ensembl chr13:43,307,775...43,313,417
JBrowse link
G Ran RAN, member RAS oncogene family increases oxidation EXP linsidomine results in increased oxidation of RAN protein CTD PMID:28086193 NCBI chr12:33,311,155...33,314,339
Ensembl chr12:27,674,050...27,678,276
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO linsidomine results in decreased phosphorylation of RB1 protein CTD PMID:12600834 NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [linsidomine affects the activity of RELA protein]; linsidomine affects the localization of and affects the activity of RELA protein CTD PMID:29175419 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rexo5 RNA exonuclease 5 increases oxidation EXP linsidomine results in increased oxidation of REXO5 protein CTD PMID:28086193 NCBI chr 1:183,599,954...183,698,433
Ensembl chr 1:174,168,694...174,241,486
JBrowse link
G Rps12 ribosomal protein S12 affects expression EXP linsidomine affects the expression of RPS12 protein CTD PMID:21204247 NCBI chr 1:23,499,943...23,502,234
Ensembl chr 1:21,680,852...21,683,014
JBrowse link
G Ryr2 ryanodine receptor 2 increases oxidation EXP linsidomine results in increased oxidation of RYR2 protein CTD PMID:28086193 NCBI chr17:63,081,527...63,667,141
Ensembl chr17:58,389,925...58,975,142
JBrowse link
G Sclt1 sodium channel and clathrin linker 1 increases oxidation EXP linsidomine results in increased oxidation of SCLT1 protein CTD PMID:28086193 NCBI chr 2:126,533,436...126,691,879
Ensembl chr 2:124,605,658...124,764,065
JBrowse link
G Scn8a sodium voltage-gated channel alpha subunit 8 increases oxidation EXP linsidomine results in increased oxidation of SCN8A protein CTD PMID:28086193 NCBI chr 7:133,860,901...134,034,809
Ensembl chr 7:131,982,480...132,151,292
JBrowse link
G Secisbp2 SECIS binding protein 2 increases oxidation EXP linsidomine results in increased oxidation of SECISBP2 protein CTD PMID:28086193 NCBI chr17:13,690,263...13,721,303
Ensembl chr17:13,538,513...13,569,523
JBrowse link
G Sfrp4 secreted frizzled-related protein 4 increases oxidation EXP linsidomine results in increased oxidation of SFRP4 protein CTD PMID:28086193 NCBI chr17:49,974,532...50,026,448
Ensembl chr17:45,234,097...45,330,736
JBrowse link
G Slc12a2 solute carrier family 12 member 2 multiple interactions
increases activity
EXP linsidomine results in increased phosphorylation of and results in increased expression of SLC12A2 protein
linsidomine results in increased activity of SLC12A2 protein
CTD PMID:25817889 NCBI chr18:53,546,263...53,614,478
Ensembl chr18:51,348,302...51,416,440
JBrowse link
G Smc1a structural maintenance of chromosomes 1A increases oxidation EXP linsidomine results in increased oxidation of SMC1A protein CTD PMID:28086193 NCBI chr  X:24,582,732...24,627,462
Ensembl chr  X:21,103,282...21,148,056
JBrowse link
G Snca synuclein alpha increases expression
multiple interactions
ISO linsidomine results in increased expression of SNCA protein
Selegiline inhibits the reaction [linsidomine results in increased expression of SNCA protein]
CTD PMID:12880480 NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:89,696,420...89,796,262
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO linsidomine results in decreased activity of and results in decreased expression of SOD1 protein; Plant Extracts inhibits the reaction [linsidomine results in decreased activity of and results in decreased expression of SOD1 protein] CTD PMID:23174672 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression
increases response to substance
ISO Acetylcysteine inhibits the reaction [linsidomine results in increased expression of SOD2 mRNA]; Cysteine inhibits the reaction [linsidomine results in increased expression of SOD2 mRNA]
SOD2 protein results in increased susceptibility to linsidomine
CTD PMID:9741582 PMID:10511315 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Speg striated muscle enriched protein kinase increases oxidation EXP linsidomine results in increased oxidation of SPEG protein CTD PMID:28086193 NCBI chr 9:84,314,387...84,371,816
Ensembl chr 9:76,865,754...76,923,144
JBrowse link
G Sst somatostatin increases secretion EXP linsidomine results in increased secretion of SST protein CTD PMID:17961553 NCBI chr11:90,461,546...90,462,823
Ensembl chr11:76,956,896...76,958,173
JBrowse link
G Svep1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 increases oxidation EXP linsidomine results in increased oxidation of SVEP1 protein CTD PMID:28086193 NCBI chr 5:72,811,200...72,988,185
Ensembl chr 5:72,811,410...72,988,525
JBrowse link
G Synrg synergin, gamma increases oxidation EXP linsidomine results in increased oxidation of SYNRG protein CTD PMID:28086193 NCBI chr10:69,346,154...69,428,714
Ensembl chr10:68,849,642...68,931,250
JBrowse link
G Sytl4 synaptotagmin-like 4 increases oxidation EXP linsidomine results in increased oxidation of SYTL4 protein CTD PMID:28086193 NCBI chr  X:101,428,785...101,479,207
Ensembl chr  X:97,135,500...97,185,854
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases expression
increases activity
EXP 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide inhibits the reaction [linsidomine results in decreased expression of TGFB1 mRNA]; 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide inhibits the reaction [linsidomine results in decreased expression of TGFB1 protein]
linsidomine results in decreased expression of TGFB1 mRNA; linsidomine results in decreased expression of TGFB1 protein
linsidomine results in increased activity of TGFB1 protein
CTD PMID:11994256 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO TLR4 gene mutant form inhibits the reaction [linsidomine results in increased secretion of IL6 protein]; TLR4 gene mutant form inhibits the reaction [linsidomine results in increased secretion of TNF protein] CTD PMID:29175419 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor increases secretion
multiple interactions
ISO linsidomine results in increased secretion of TNF protein
TLR4 gene mutant form inhibits the reaction [linsidomine results in increased secretion of TNF protein]
CTD PMID:29175419 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Trim40 tripartite motif-containing 40 increases oxidation EXP linsidomine results in increased oxidation of TRIM40 protein CTD PMID:28086193 NCBI chr20:1,680,554...1,691,123
Ensembl chr20:1,676,270...1,685,214
JBrowse link
G Trpm1 transient receptor potential cation channel, subfamily M, member 1 increases oxidation EXP linsidomine results in increased oxidation of TRPM1 protein CTD PMID:28086193 NCBI chr 1:117,718,896...117,835,434
Ensembl chr 1:117,718,896...117,834,605
JBrowse link
G Trpm7 transient receptor potential cation channel, subfamily M, member 7 increases oxidation EXP linsidomine results in increased oxidation of TRPM7 protein CTD PMID:28086193 NCBI chr 3:134,499,617...134,588,113
Ensembl chr 3:114,046,258...114,135,190
JBrowse link
G Unc13a unc-13 homolog A increases oxidation EXP linsidomine results in increased oxidation of UNC13A protein CTD PMID:28086193 NCBI chr16:18,367,891...18,415,808
Ensembl chr16:18,336,229...18,381,872
JBrowse link
G Vgf VGF nerve growth factor inducible increases oxidation EXP linsidomine results in increased oxidation of VGF protein CTD PMID:28086193 NCBI chr12:25,274,004...25,281,803
Ensembl chr12:19,637,320...19,640,341
JBrowse link
G Vim vimentin increases oxidation EXP linsidomine results in increased oxidation of VIM protein CTD PMID:28086193 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Wdr7 WD repeat domain 7 increases oxidation EXP linsidomine results in increased oxidation of WDR7 protein CTD PMID:28086193 NCBI chr18:57,165,482...57,448,568
Ensembl chr18:57,165,488...57,448,540
JBrowse link
G Whrn whirlin increases oxidation EXP linsidomine results in increased oxidation of WHRN protein CTD PMID:28086193 NCBI chr 5:81,843,820...81,933,400
Ensembl chr 5:76,828,301...76,912,223
JBrowse link
G Ythdc1 YTH N6-methyladenosine RNA binding protein C1 increases oxidation EXP linsidomine results in increased oxidation of YTHDC1 protein CTD PMID:28086193 NCBI chr14:21,540,276...21,570,724
Ensembl chr14:21,185,440...21,216,028
JBrowse link
G Zfp148 zinc finger protein 148 increases oxidation EXP linsidomine results in increased oxidation of ZFP148 protein CTD PMID:28086193 NCBI chr11:80,780,865...80,890,877
Ensembl chr11:67,281,707...67,385,772
JBrowse link
G Zfp518a zinc finger protein 518A increases oxidation EXP linsidomine results in increased oxidation of ZFP518A protein CTD PMID:28086193 NCBI chr 1:249,668,815...249,694,401
Ensembl chr 1:239,719,505...239,744,979
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    chemical entity 19897
      atom 19897
        nonmetal atom 19820
          nitrogen atom 19000
            nitrogen molecular entity 19000
              organonitrogen compound 18854
                organonitrogen heterocyclic compound 18178
                  oxazinane 911
                    morpholines 911
                      linsidomine 137
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19836
                    p-block element atom 19836
                      carbon group element atom 19776
                        carbon atom 19772
                          organic molecular entity 19772
                            organic molecule 19725
                              organic cyclic compound 19517
                                organic heterocyclic compound 18894
                                  organic heteromonocyclic compound 17817
                                    oxazinane 911
                                      morpholines 911
                                        linsidomine 137
paths to the root