CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: linsidomine
Accession: CHEBI:136004
browse the term
Synonyms: related_synonym: Formula=C6H10N4O2; InChI=1S/C6H10N4O2/c7-6-5-10(8-12-6)9-1-3-11-4-2-9/h5,7H,1-4H2; InChIKey=FKDHHVKWGRFRTG-UHFFFAOYSA-N; SMILES=C1CN(CCO1)[N+]2=CC(O[N-]2)=N; linsidomine HCl; linsidomine hydrochloride
xref: CAS:33876-97-0; Drug_Central:4589
xref_mesh: MESH:C002385
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Abca5
ATP binding cassette subfamily A member 5
increases oxidation
EXP
linsidomine results in increased oxidation of ABCA5 protein
CTD
PMID:28086193
NCBI chr10:95,739,610...95,808,633
Ensembl chr10:95,240,154...95,308,976
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Acp5
acid phosphatase 5, tartrate resistant
increases oxidation
EXP
linsidomine results in increased oxidation of ACP5 protein
CTD
PMID:28086193
NCBI chr 8:28,939,984...28,946,639
Ensembl chr 8:20,663,985...20,667,929
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Agrn
agrin
increases oxidation
EXP
linsidomine results in increased oxidation of AGRN protein
CTD
PMID:28086193
NCBI chr 5:172,031,528...172,064,429
Ensembl chr 5:166,749,310...166,786,003
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Akt1
AKT serine/threonine kinase 1
increases metabolic processing multiple interactions increases phosphorylation
ISO EXP
linsidomine results in increased metabolism of AKT1 protein linsidomine inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein] wortmannin inhibits the reaction [linsidomine results in increased phosphorylation of AKT1 protein]
CTD
PMID:17302912 PMID:19682478
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
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Anxa2
annexin A2
decreases expression
EXP
linsidomine results in decreased expression of ANXA2 protein
CTD
PMID:21204247
NCBI chr 8:78,986,252...79,022,638
Ensembl chr 8:70,105,253...70,141,658
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Ap2a2
adaptor related protein complex 2 subunit alpha 2
increases oxidation
EXP
linsidomine results in increased oxidation of AP2A2 protein
CTD
PMID:28086193
NCBI chr 1:196,652,315...196,725,609
Ensembl chr 1:196,652,337...196,725,603
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Apba1
amyloid beta precursor protein binding family A member 1
increases oxidation
EXP
linsidomine results in increased oxidation of APBA1 protein
CTD
PMID:28086193
NCBI chr 1:230,790,297...230,995,986
Ensembl chr 1:221,363,778...221,566,553
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Apob
apolipoprotein B
increases oxidation
EXP
linsidomine results in increased oxidation of APOB protein
CTD
PMID:28086193
NCBI chr 6:36,563,704...36,603,300
Ensembl chr 6:30,844,368...30,892,497
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Arnt2
aryl hydrocarbon receptor nuclear translocator 2
increases oxidation
EXP
linsidomine results in increased oxidation of ARNT2 protein
CTD
PMID:28086193
NCBI chr 1:147,645,354...147,801,986
Ensembl chr 1:138,189,940...138,393,153
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Atf4
activating transcription factor 4
increases expression
ISO
linsidomine results in increased expression of ATF4 mRNA
CTD
PMID:21703327
NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:111,804,183...111,806,446
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Avp
arginine vasopressin
increases expression
EXP
linsidomine results in increased expression of AVP mRNA
CTD
PMID:10460269
NCBI chr 3:138,246,544...138,248,522
Ensembl chr 3:117,793,457...117,795,425
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Avpr1b
arginine vasopressin receptor 1B
increases oxidation
EXP
linsidomine results in increased oxidation of AVPR1B protein
CTD
PMID:28086193
NCBI chr13:45,598,116...45,611,680
Ensembl chr13:43,046,267...43,057,792
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Bax
BCL2 associated X, apoptosis regulator
increases expression multiple interactions
ISO
linsidomine results in increased expression of BAX MT1A inhibits the reaction [linsidomine results in increased expression of BAX] linsidomine results in increased expression of BAX protein Selegiline inhibits the reaction [linsidomine results in increased expression of BAX protein]
CTD
PMID:12880480 PMID:16291239
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
decreases expression multiple interactions
ISO
linsidomine results in decreased expression of BCL2; linsidomine results in decreased expression of BCL2 protein MT1A inhibits the reaction [linsidomine results in decreased expression of BCL2]; Plant Extracts inhibits the reaction [linsidomine results in decreased expression of BCL2 protein] [linsidomine results in increased abundance of Nitric Oxide] which results in increased expression of BCL2 mRNA; [linsidomine results in increased abundance of Nitric Oxide] which results in increased expression of BCL2 protein; Selegiline inhibits the reaction [linsidomine results in decreased expression of BCL2 protein]
CTD
PMID:7706495 PMID:12880480 PMID:16291239 PMID:23174672
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Brca2
BRCA2, DNA repair associated
increases oxidation
EXP
linsidomine results in increased oxidation of BRCA2 protein
CTD
PMID:28086193
NCBI chr12:4,895,092...4,939,340
Ensembl chr12:59,819...100,567
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Cacna1c
calcium voltage-gated channel subunit alpha1 C
multiple interactions
ISO
[linsidomine co-treated with Peroxynitrous Acid] results in increased nitrosation of CACNA1C protein
CTD
PMID:17551092
NCBI chr 4:153,431,169...154,051,932
Ensembl chr 4:151,764,138...152,379,648
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Cacna1e
calcium voltage-gated channel subunit alpha1 E
increases oxidation
EXP
linsidomine results in increased oxidation of CACNA1E protein
CTD
PMID:28086193
NCBI chr13:69,125,048...69,613,795
Ensembl chr13:66,581,920...66,894,450
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Cacna1h
calcium voltage-gated channel subunit alpha1 H
increases oxidation
EXP
linsidomine results in increased oxidation of CACNA1H protein
CTD
PMID:28086193
NCBI chr10:14,894,630...14,952,317
Ensembl chr10:14,390,113...14,448,376
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Cacnb2
calcium voltage-gated channel auxiliary subunit beta 2
increases oxidation
EXP
linsidomine results in increased oxidation of CACNB2 protein
CTD
PMID:28086193
NCBI chr17:82,473,097...82,818,564
Ensembl chr17:77,564,460...77,909,106
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Calca
calcitonin-related polypeptide alpha
increases response to substance
EXP
CALCA protein results in increased susceptibility to linsidomine
CTD
PMID:8581270
NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:168,878,214...168,883,105
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Carm1
coactivator-associated arginine methyltransferase 1
increases oxidation
EXP
linsidomine results in increased oxidation of CARM1 protein
CTD
PMID:28086193
NCBI chr 8:28,373,370...28,418,056
Ensembl chr 8:20,097,254...20,147,689
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Casp3
caspase 3
increases activity increases cleavage increases expression multiple interactions
ISO EXP
linsidomine results in increased activity of CASP3 protein linsidomine results in increased cleavage of CASP3 protein linsidomine results in increased expression of CASP3 mRNA; linsidomine results in increased expression of CASP3 protein; linsidomine results in increased expression of CASP3 protein modified form Melatonin inhibits the reaction [linsidomine results in increased expression of CASP3 mRNA]; MT1A inhibits the reaction [linsidomine results in increased activity of CASP3 protein]; Plant Extracts inhibits the reaction [linsidomine results in increased cleavage of CASP3 protein]; Plant Extracts inhibits the reaction [linsidomine results in increased expression of CASP3 protein modified form]; Selegiline inhibits the reaction [linsidomine results in increased expression of CASP3 mRNA]; Selegiline inhibits the reaction [linsidomine results in increased expression of CASP3 protein]; Ubiquinone inhibits the reaction [linsidomine results in increased expression of CASP3 mRNA]
CTD
PMID:12880480 PMID:15686499 PMID:16291239 PMID:19038279 PMID:23174672
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
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Cat
catalase
multiple interactions
ISO
linsidomine results in decreased activity of and results in decreased expression of CAT protein; Plant Extracts inhibits the reaction [linsidomine results in decreased activity of and results in decreased expression of CAT protein] CAT protein inhibits the reaction [linsidomine results in decreased expression of CCND1 mRNA]; CAT protein inhibits the reaction [linsidomine results in decreased expression of CCND1 protein]
CTD
PMID:12600834 PMID:23174672
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
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Ccnd1
cyclin D1
multiple interactions decreases expression
ISO
CAT protein inhibits the reaction [linsidomine results in decreased expression of CCND1 mRNA]; CAT protein inhibits the reaction [linsidomine results in decreased expression of CCND1 protein] linsidomine results in decreased expression of CCND1 mRNA; linsidomine results in decreased expression of CCND1 protein
CTD
PMID:12600834
NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602
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Cep83
centrosomal protein 83
increases oxidation
EXP
linsidomine results in increased oxidation of CEP83 protein
CTD
PMID:28086193
NCBI chr 7:29,280,358...29,389,574
Ensembl chr 7:29,280,419...29,389,574
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Cep95
centrosomal protein 95
increases oxidation
EXP
linsidomine results in increased oxidation of CEP95 protein
CTD
PMID:28086193
NCBI chr10:92,231,829...92,259,813
Ensembl chr10:91,732,111...91,760,092
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Cldn5
claudin 5
decreases expression
ISO
linsidomine results in decreased expression of CLDN5 protein
CTD
PMID:34391839
NCBI chr11:95,717,172...95,718,598
Ensembl chr11:82,211,475...82,214,992
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Clrn1
clarin 1
increases oxidation
EXP
linsidomine results in increased oxidation of CLRN1 protein
CTD
PMID:28086193
NCBI chr 2:143,084,030...143,130,948
Ensembl chr 2:143,084,030...143,130,948
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Clu
clusterin
increases oxidation
EXP
linsidomine results in increased oxidation of CLU protein
CTD
PMID:28086193
NCBI chr15:44,336,619...44,375,861
Ensembl chr15:40,174,617...40,200,315
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Crh
corticotropin releasing hormone
multiple interactions increases expression
EXP
CRH protein affects the reaction [linsidomine results in increased secretion of POMC protein alternative form] linsidomine results in increased expression of CRH mRNA
CTD
PMID:10460269
NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:102,143,055...102,144,919
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Crhr1
corticotropin releasing hormone receptor 1
increases expression
EXP
linsidomine results in increased expression of CRHR1 mRNA
CTD
PMID:10460269
NCBI chr10:89,540,192...89,583,466
Ensembl chr10:89,040,203...89,083,481
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Cttnbp2
cortactin binding protein 2
increases oxidation
EXP
linsidomine results in increased oxidation of CTTNBP2 protein
CTD
PMID:28086193
NCBI chr 4:47,766,867...47,930,598
Ensembl chr 4:46,800,981...46,964,631
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Cycs
cytochrome c, somatic
affects localization multiple interactions
ISO
linsidomine affects the localization of CYCS protein Selegiline inhibits the reaction [linsidomine affects the localization of CYCS protein]
CTD
PMID:12880480
NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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Ddit3
DNA-damage inducible transcript 3
increases expression
ISO
linsidomine results in increased expression of DDIT3 mRNA
CTD
PMID:21703327
NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201
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Ddx52
DExD-box helicase 52
increases oxidation
EXP
linsidomine results in increased oxidation of DDX52 protein
CTD
PMID:28086193
NCBI chr10:68,824,594...68,847,400
Ensembl chr10:68,824,645...68,848,266
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Dlgap4
DLG associated protein 4
increases oxidation
EXP
linsidomine results in increased oxidation of DLGAP4 protein
CTD
PMID:28086193
NCBI chr 3:145,124,189...145,271,791
Ensembl chr 3:145,175,479...145,270,490
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Dnah7
dynein, axonemal, heavy chain 7
increases oxidation
EXP
linsidomine results in increased oxidation of DNAH7 protein
CTD
PMID:28086193
NCBI chr 9:62,454,838...62,760,504
Ensembl chr 9:54,960,440...55,262,297
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Dnmt1
DNA methyltransferase 1
increases oxidation
EXP
linsidomine results in increased oxidation of DNMT1 protein
CTD
PMID:28086193
NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:19,440,611...19,486,659
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Dscam
DS cell adhesion molecule
increases oxidation
EXP
linsidomine results in increased oxidation of DSCAM protein
CTD
PMID:28086193
NCBI chr11:35,921,924...36,507,100
Ensembl chr11:35,926,896...36,507,415
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E2f2
E2F transcription factor 2
decreases activity
ISO
linsidomine results in decreased activity of E2F2 protein
CTD
PMID:12600834
NCBI chr 5:153,682,789...153,706,087
Ensembl chr 5:148,399,642...148,421,217
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Eaf2
ELL associated factor 2
increases oxidation
EXP
linsidomine results in increased oxidation of EAF2 protein
CTD
PMID:28086193
NCBI chr11:77,465,585...77,509,993
Ensembl chr11:63,960,200...64,004,610
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Eif2ak3
eukaryotic translation initiation factor 2 alpha kinase 3
increases phosphorylation
ISO
linsidomine results in increased phosphorylation of EIF2AK3 protein
CTD
PMID:21703327
NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:102,805,510...102,866,911
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Eif2s1
eukaryotic translation initiation factor 2 subunit alpha
increases phosphorylation
ISO
linsidomine results in increased phosphorylation of EIF2S1 protein
CTD
PMID:21703327
NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:97,672,766...97,706,225
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Ephx2
epoxide hydrolase 2
increases oxidation
EXP
linsidomine results in increased oxidation of EPHX2 protein
CTD
PMID:28086193
NCBI chr15:44,465,447...44,503,157
Ensembl chr15:40,289,902...40,327,615
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Evl
Enah/Vasp-like
increases oxidation
EXP
linsidomine results in increased oxidation of EVL protein
CTD
PMID:28086193
NCBI chr 6:133,238,547...133,358,730
Ensembl chr 6:127,474,543...127,594,344
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Fam221b
family with sequence similarity 221, member B
increases oxidation
EXP
linsidomine results in increased oxidation of FAM221B protein
CTD
PMID:28086193
NCBI chr 5:57,910,346...57,919,562
Ensembl chr 5:57,910,352...57,919,367
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Faslg
Fas ligand
multiple interactions
ISO
[linsidomine results in increased abundance of Nitric Oxide] inhibits the reaction [Etoposide results in increased activity of FASLG promoter]; [linsidomine results in increased abundance of Nitric Oxide] inhibits the reaction [N-caproylsphingosine results in increased activity of FASLG promoter]
CTD
PMID:10811113
NCBI chr13:76,680,885...76,706,042
Ensembl chr13:74,154,954...74,162,215
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Fasn
fatty acid synthase
increases oxidation
EXP
linsidomine results in increased oxidation of FASN protein
CTD
PMID:28086193
NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,072,091...106,090,261
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Fra10ac1
FRA10A associated CGG repeat 1
increases oxidation
EXP
linsidomine results in increased oxidation of FRA10AC1 protein
CTD
PMID:28086193
NCBI chr 1:235,969,071...236,001,074
Ensembl chr 1:235,969,112...236,001,210
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Gabra5
gamma-aminobutyric acid type A receptor subunit alpha 5
increases oxidation
EXP
linsidomine results in increased oxidation of GABRA5 protein
CTD
PMID:28086193
NCBI chr 1:117,404,446...117,517,424
Ensembl chr 1:108,268,776...108,380,917
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Glg1
golgi glycoprotein 1
increases oxidation
EXP
linsidomine results in increased oxidation of GLG1 protein
CTD
PMID:28086193
NCBI chr19:56,034,248...56,133,538
Ensembl chr19:39,124,641...39,224,178
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Golga4
golgin A4
increases oxidation
EXP
linsidomine results in increased oxidation of GOLGA4 protein
CTD
PMID:28086193
NCBI chr 8:118,208,200...118,285,003
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Grm7
glutamate metabotropic receptor 7
increases oxidation
EXP
linsidomine results in increased oxidation of GRM7 protein
CTD
PMID:28086193
NCBI chr 4:143,730,862...144,613,230
Ensembl chr 4:143,731,259...144,612,344
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Gsta2
glutathione S-transferase alpha 2
increases expression
EXP
linsidomine results in increased expression of GSTA2; linsidomine results in increased expression of GSTA2 protein
CTD
PMID:12446173 PMID:15357004
NCBI chr 8:88,064,829...88,077,168
Ensembl chr 8:79,184,322...79,196,798
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Gucy2e
guanylate cyclase 2E
increases oxidation
EXP
linsidomine results in increased oxidation of GUCY2E protein
CTD
PMID:28086193
NCBI chr10:54,453,753...54,478,639
Ensembl chr10:53,959,010...53,974,067
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Hadha
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
increases oxidation
EXP
linsidomine results in increased oxidation of HADHA protein
CTD
PMID:28086193
NCBI chr 6:31,907,801...31,947,434
Ensembl chr 6:26,187,956...26,227,869
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Hgs
hepatocyte growth factor-regulated tyrosine kinase substrate
increases oxidation
EXP
linsidomine results in increased oxidation of HGS protein
CTD
PMID:28086193
NCBI chr10:105,739,617...105,757,838
Ensembl chr10:105,739,296...105,757,835
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Hist1h2bg
histone cluster 1, H2bg
increases oxidation
EXP
linsidomine results in increased oxidation of HIST1H2BG protein
CTD
PMID:28086193
NCBI chr17:41,999,269...42,000,237
Ensembl chr17:41,571,210...41,571,896
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Hmox1
heme oxygenase 1
multiple interactions increases expression
ISO
[linsidomine co-treated with Nitroprusside] results in increased expression of HMOX1 mRNA; [linsidomine co-treated with S-Nitrosoglutathione] results in increased expression of HMOX1 mRNA linsidomine results in increased expression of HMOX1 mRNA
CTD
PMID:8764571 PMID:10423162
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
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Hnrnpm
heterogeneous nuclear ribonucleoprotein M
increases oxidation
EXP
linsidomine results in increased oxidation of HNRNPM protein
CTD
PMID:28086193
NCBI chr 7:15,140,877...15,178,871
Ensembl chr 7:14,438,688...14,476,762
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Hormad1
HORMA domain containing 1
increases oxidation
EXP
linsidomine results in increased oxidation of HORMAD1 protein
CTD
PMID:28086193
NCBI chr 2:185,803,572...185,841,449
Ensembl chr 2:183,116,716...183,152,383
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Il6
interleukin 6
multiple interactions increases secretion
ISO
TLR4 gene mutant form inhibits the reaction [linsidomine results in increased secretion of IL6 protein]
CTD
PMID:29175419
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
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Ilk
integrin-linked kinase
increases oxidation
EXP
linsidomine results in increased oxidation of ILK protein
CTD
PMID:28086193
NCBI chr 1:169,500,716...169,506,972
Ensembl chr 1:160,088,897...160,095,140
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Ins1
insulin 1
multiple interactions
ISO
linsidomine inhibits the reaction [INS1 protein binds to PIK3R1 protein]; linsidomine inhibits the reaction [INS1 protein results in increased activity of PIK3R1 protein]; linsidomine inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]; linsidomine inhibits the reaction [INS1 protein results in increased phosphorylation of INSR protein]; linsidomine inhibits the reaction [INS1 protein results in increased phosphorylation of IRS1 protein]
CTD
PMID:19682478
NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:251,244,973...251,245,536
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Insr
insulin receptor
multiple interactions increases metabolic processing
ISO
linsidomine inhibits the reaction [INS1 protein results in increased phosphorylation of INSR protein] linsidomine results in increased metabolism of INSR protein
CTD
PMID:19682478
NCBI chr12:5,991,135...6,129,275
Ensembl chr12:1,197,100...1,330,883
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Iqsec3
IQ motif and Sec7 domain ArfGEF 3
increases oxidation
EXP
linsidomine results in increased oxidation of IQSEC3 protein
CTD
PMID:28086193
NCBI chr 4:156,283,040...156,379,396
Ensembl chr 4:154,610,934...154,707,310
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Irs1
insulin receptor substrate 1
multiple interactions
ISO
linsidomine inhibits the reaction [INS1 protein results in increased phosphorylation of IRS1 protein]; linsidomine results in increased metabolism of and results in decreased expression of IRS1 protein
CTD
PMID:19682478
NCBI chr 9:91,001,137...91,053,959
Ensembl chr 9:83,548,944...83,606,122
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Itpr1
inositol 1,4,5-trisphosphate receptor, type 1
multiple interactions increases expression
ISO
Cycloheximide inhibits the reaction [linsidomine results in increased expression of ITPR1 mRNA]; Dactinomycin inhibits the reaction [linsidomine results in increased expression of ITPR1 mRNA]
CTD
PMID:17241155
NCBI chr 4:142,743,401...143,066,505
Ensembl chr 4:141,187,418...141,510,491
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Itpr3
inositol 1,4,5-trisphosphate receptor, type 3
increases oxidation
EXP
linsidomine results in increased oxidation of ITPR3 protein
CTD
PMID:28086193
NCBI chr20:5,138,553...5,204,189
Ensembl chr20:5,136,441...5,202,337
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Kat6a
lysine acetyltransferase 6A
increases oxidation
EXP
linsidomine results in increased oxidation of KAT6A protein
CTD
PMID:28086193
NCBI chr16:75,787,411...75,868,584
Ensembl chr16:69,084,914...69,163,606
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Keap1
Kelch-like ECH-associated protein 1
affects response to substance
ISO
KEAP1 mRNA affects the susceptibility to linsidomine
CTD
PMID:16092930
NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:19,768,375...19,777,862
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Khdrbs2
KH RNA binding domain containing, signal transduction associated 2
increases oxidation
EXP
linsidomine results in increased oxidation of KHDRBS2 protein
CTD
PMID:28086193
NCBI chr 9:41,943,029...42,449,687
Ensembl chr 9:34,447,056...34,915,530
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Klk8
kallikrein related-peptidase 8
increases oxidation
EXP
linsidomine results in increased oxidation of KLK8 protein
CTD
PMID:28086193
NCBI chr 1:103,388,352...103,395,195
Ensembl chr 1:94,251,803...94,258,646
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Mapk8
mitogen-activated protein kinase 8
multiple interactions increases phosphorylation
ISO
bosutinib affects the reaction [linsidomine results in increased phosphorylation of MAPK8 protein]
CTD
PMID:34519134
NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981
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Mprip
myosin phosphatase Rho interacting protein
increases oxidation
EXP
linsidomine results in increased oxidation of MPRIP protein
CTD
PMID:28086193
NCBI chr10:44,953,472...45,073,388
Ensembl chr10:44,453,929...44,569,118
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Mt1
metallothionein 1
multiple interactions decreases response to substance increases expression
ISO
MT1A inhibits the reaction [linsidomine results in decreased expression of BCL2]; MT1A inhibits the reaction [linsidomine results in increased activity of CASP3 protein]; MT1A inhibits the reaction [linsidomine results in increased expression of BAX] MT1 protein results in decreased susceptibility to linsidomine linsidomine results in increased expression of MT1 protein Selegiline inhibits the reaction [linsidomine results in increased expression of MT1 protein]
CTD
PMID:12880480 PMID:16291239
NCBI chr19:10,831,959...10,832,975
Ensembl chr19:10,826,032...10,827,049 Ensembl chr17:10,826,032...10,827,049 Ensembl chr X:10,826,032...10,827,049
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Mtfr1
mitochondrial fission regulator 1
increases oxidation
EXP
linsidomine results in increased oxidation of MTFR1 protein
CTD
PMID:28086193
NCBI chr 2:103,594,458...103,629,697
Ensembl chr 2:101,679,265...101,713,544
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Mtor
mechanistic target of rapamycin kinase
increases oxidation
EXP
linsidomine results in increased oxidation of MTOR protein
CTD
PMID:28086193
NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311
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Mybpc3
myosin binding protein C3
increases oxidation
EXP
linsidomine results in increased oxidation of MYBPC3 protein
CTD
PMID:28086193
NCBI chr 3:97,550,974...97,569,216
Ensembl chr 3:77,095,252...77,113,405
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Nat1
N-acetyltransferase 1
decreases activity
ISO
linsidomine results in decreased activity of NAT1 protein
CTD
PMID:14672957
NCBI chr16:26,984,882...27,005,194
Ensembl chr16:22,208,194...22,238,520
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Nbr1
NBR1, autophagy cargo receptor
increases oxidation
EXP
linsidomine results in increased oxidation of NBR1 protein
CTD
PMID:28086193
NCBI chr10:86,978,024...87,006,664
Ensembl chr10:86,478,290...86,506,412
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Nf1
neurofibromin 1
increases oxidation
EXP
linsidomine results in increased oxidation of NF1 protein
CTD
PMID:28086193
NCBI chr10:64,803,986...65,037,086
Ensembl chr10:64,306,301...64,536,658
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Nfe2l2
NFE2 like bZIP transcription factor 2
multiple interactions decreases response to substance
ISO EXP
[linsidomine results in increased expression of NFE2L2 protein] which results in decreased susceptibility to Oxidopamine NFE2L2 protein results in decreased susceptibility to linsidomine 1,2-dithiol-3-thione promotes the reaction [NFE2L2 results in decreased susceptibility to linsidomine] linsidomine results in increased localization of and results in increased activity of NFE2L2 protein
CTD
PMID:12446173 PMID:16092930 PMID:18367636
NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737
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Nos1
nitric oxide synthase 1
increases expression increases oxidation
EXP
linsidomine results in increased expression of NOS1 mRNA linsidomine results in increased oxidation of NOS1 protein
CTD
PMID:19038279 PMID:28086193
NCBI chr12:44,276,011...44,456,371
Ensembl chr12:38,626,714...38,710,945
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Nos2
nitric oxide synthase 2
increases expression multiple interactions
ISO
linsidomine results in increased expression of NOS2 protein [linsidomine results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitrites; [Plant Extracts inhibits the reaction [linsidomine results in increased expression of NOS2 protein]] which results in decreased chemical synthesis of Nitrites; Plant Extracts inhibits the reaction [linsidomine results in increased expression of NOS2 protein]
CTD
PMID:23174672
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
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Nr4a1
nuclear receptor subfamily 4, group A, member 1
increases expression
EXP
linsidomine results in increased expression of NR4A1 mRNA
CTD
PMID:10460269
NCBI chr 7:134,247,153...134,268,044
Ensembl chr 7:132,374,840...132,389,297
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Oma1
OMA1 zinc metallopeptidase
increases oxidation
EXP
linsidomine results in increased oxidation of OMA1 protein
CTD
PMID:28086193
NCBI chr 5:118,083,728...118,136,980
Ensembl chr 5:118,083,728...118,136,980
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Parp1
poly (ADP-ribose) polymerase 1
multiple interactions decreases expression decreases folding decreases activity increases cleavage
ISO
Selegiline inhibits the reaction [linsidomine results in decreased expression of PARP1 protein] linsidomine results in decreased folding of PARP1 protein [bosutinib co-treated with linsidomine] affects the expression of PARP1 protein; bosutinib affects the reaction [linsidomine results in increased cleavage of PARP1 protein]; linsidomine inhibits the reaction [PARP1 protein binds to Zinc]; linsidomine results in decreased activity of and results in increased nitrosation of PARP1 protein linsidomine results in decreased activity of PARP1 protein
CTD
PMID:12880480 PMID:31152818 PMID:34519134
NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
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Pcna
proliferating cell nuclear antigen
decreases expression
ISO
linsidomine results in decreased expression of PCNA protein
CTD
PMID:12600834
NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995
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Pds5a
PDS5 cohesin associated factor A
increases oxidation
EXP
linsidomine results in increased oxidation of PDS5A protein
CTD
PMID:28086193
NCBI chr14:42,905,734...43,004,740
Ensembl chr14:42,552,647...42,648,669
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Pepd
peptidase D
multiple interactions
ISO
linsidomine results in increased phosphorylation of and results in increased activity of PEPD protein
CTD
PMID:16167338
NCBI chr 1:87,536,650...87,681,233
Ensembl chr 1:87,536,609...87,681,231
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Per2
period circadian regulator 2
decreases response to substance
ISO
PER2 protein mutant form results in decreased susceptibility to linsidomine
CTD
PMID:25628599
NCBI chr 9:99,454,828...99,497,069
Ensembl chr 9:92,007,296...92,049,459
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Pi4ka
phosphatidylinositol 4-kinase alpha
increases oxidation
EXP
linsidomine results in increased oxidation of PI4KA protein
CTD
PMID:28086193
NCBI chr11:83,609,148...83,726,876
Ensembl chr11:83,609,069...83,724,080
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Pif1
PIF1 5'-to-3' DNA helicase
increases oxidation
EXP
linsidomine results in increased oxidation of PIF1 protein
CTD
PMID:28086193
NCBI chr 8:75,005,820...75,015,331
Ensembl chr 8:66,111,072...66,120,200
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Pik3r1
phosphoinositide-3-kinase regulatory subunit 1
multiple interactions
ISO
linsidomine inhibits the reaction [INS1 protein binds to PIK3R1 protein]; linsidomine inhibits the reaction [INS1 protein results in increased activity of PIK3R1 protein]
CTD
PMID:19682478
NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:32,882,032...32,963,631
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Plb1
phospholipase B1
increases oxidation
EXP
linsidomine results in increased oxidation of PLB1 protein
CTD
PMID:28086193
NCBI chr 6:29,807,127...29,945,607
Ensembl chr 6:24,089,214...24,210,117
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Plekhg5
pleckstrin homology and RhoGEF domain containing G5
increases oxidation
EXP
linsidomine results in increased oxidation of PLEKHG5 protein
CTD
PMID:28086193
NCBI chr 5:162,577,999...162,621,518
Ensembl chr 5:162,578,071...162,621,513
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Pomc
proopiomelanocortin
multiple interactions increases secretion
EXP
CRH protein affects the reaction [linsidomine results in increased secretion of POMC protein alternative form]
CTD
PMID:10460269
NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:26,939,837...26,945,664
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Ppp1r37
protein phosphatase 1, regulatory subunit 37
increases oxidation
EXP
linsidomine results in increased oxidation of PPP1R37 protein
CTD
PMID:28086193
NCBI chr 1:88,308,782...88,340,796
Ensembl chr 1:79,180,793...79,212,612
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Prkca
protein kinase C, alpha
multiple interactions
EXP
[linsidomine co-treated with Staurosporine] results in decreased expression of PRKCA protein; Staurosporine inhibits the reaction [linsidomine results in increased phosphorylation of PRKCA protein]
CTD
PMID:11994256
NCBI chr10:93,388,991...93,787,617
Ensembl chr10:92,894,012...93,288,012
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Prkn
parkin RBR E3 ubiquitin protein ligase
increases expression multiple interactions
ISO
linsidomine results in increased expression of PRKN protein Selegiline inhibits the reaction [linsidomine results in increased expression of PRKN protein]
CTD
PMID:12880480
NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:48,690,556...49,882,555
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Pten
phosphatase and tensin homolog
increases oxidation
EXP
linsidomine results in increased oxidation of PTEN protein
CTD
PMID:17302912
NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:230,630,338...230,696,838
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Rab29
RAB29, member RAS oncogene family
increases oxidation
EXP
linsidomine results in increased oxidation of RAB29 protein
CTD
PMID:28086193
NCBI chr13:45,859,930...45,865,468
Ensembl chr13:43,307,775...43,313,417
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Ran
RAN, member RAS oncogene family
increases oxidation
EXP
linsidomine results in increased oxidation of RAN protein
CTD
PMID:28086193
NCBI chr12:33,311,155...33,314,339
Ensembl chr12:27,674,050...27,678,276
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Rb1
RB transcriptional corepressor 1
decreases phosphorylation
ISO
linsidomine results in decreased phosphorylation of RB1 protein
CTD
PMID:12600834
NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [linsidomine affects the activity of RELA protein]; linsidomine affects the localization of and affects the activity of RELA protein
CTD
PMID:29175419
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
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Rexo5
RNA exonuclease 5
increases oxidation
EXP
linsidomine results in increased oxidation of REXO5 protein
CTD
PMID:28086193
NCBI chr 1:183,599,954...183,698,433
Ensembl chr 1:174,168,694...174,241,486
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Rps12
ribosomal protein S12
affects expression
EXP
linsidomine affects the expression of RPS12 protein
CTD
PMID:21204247
NCBI chr 1:23,499,943...23,502,234
Ensembl chr 1:21,680,852...21,683,014
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Ryr2
ryanodine receptor 2
increases oxidation
EXP
linsidomine results in increased oxidation of RYR2 protein
CTD
PMID:28086193
NCBI chr17:63,081,527...63,667,141
Ensembl chr17:58,389,925...58,975,142
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Sclt1
sodium channel and clathrin linker 1
increases oxidation
EXP
linsidomine results in increased oxidation of SCLT1 protein
CTD
PMID:28086193
NCBI chr 2:126,533,436...126,691,879
Ensembl chr 2:124,605,658...124,764,065
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Scn8a
sodium voltage-gated channel alpha subunit 8
increases oxidation
EXP
linsidomine results in increased oxidation of SCN8A protein
CTD
PMID:28086193
NCBI chr 7:133,860,901...134,034,809
Ensembl chr 7:131,982,480...132,151,292
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Secisbp2
SECIS binding protein 2
increases oxidation
EXP
linsidomine results in increased oxidation of SECISBP2 protein
CTD
PMID:28086193
NCBI chr17:13,690,263...13,721,303
Ensembl chr17:13,538,513...13,569,523
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Sfrp4
secreted frizzled-related protein 4
increases oxidation
EXP
linsidomine results in increased oxidation of SFRP4 protein
CTD
PMID:28086193
NCBI chr17:49,974,532...50,026,448
Ensembl chr17:45,234,097...45,330,736
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Slc12a2
solute carrier family 12 member 2
multiple interactions increases activity
EXP
linsidomine results in increased phosphorylation of and results in increased expression of SLC12A2 protein linsidomine results in increased activity of SLC12A2 protein
CTD
PMID:25817889
NCBI chr18:53,546,263...53,614,478
Ensembl chr18:51,348,302...51,416,440
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Smc1a
structural maintenance of chromosomes 1A
increases oxidation
EXP
linsidomine results in increased oxidation of SMC1A protein
CTD
PMID:28086193
NCBI chr X:24,582,732...24,627,462
Ensembl chr X:21,103,282...21,148,056
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Snca
synuclein alpha
increases expression multiple interactions
ISO
linsidomine results in increased expression of SNCA protein Selegiline inhibits the reaction [linsidomine results in increased expression of SNCA protein]
CTD
PMID:12880480
NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:89,696,420...89,796,262
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Sod1
superoxide dismutase 1
multiple interactions
ISO
linsidomine results in decreased activity of and results in decreased expression of SOD1 protein; Plant Extracts inhibits the reaction [linsidomine results in decreased activity of and results in decreased expression of SOD1 protein]
CTD
PMID:23174672
NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249
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Sod2
superoxide dismutase 2
multiple interactions increases expression increases response to substance
ISO
Acetylcysteine inhibits the reaction [linsidomine results in increased expression of SOD2 mRNA]; Cysteine inhibits the reaction [linsidomine results in increased expression of SOD2 mRNA] SOD2 protein results in increased susceptibility to linsidomine
CTD
PMID:9741582 PMID:10511315
NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189
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Speg
striated muscle enriched protein kinase
increases oxidation
EXP
linsidomine results in increased oxidation of SPEG protein
CTD
PMID:28086193
NCBI chr 9:84,314,387...84,371,816
Ensembl chr 9:76,865,754...76,923,144
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Sst
somatostatin
increases secretion
EXP
linsidomine results in increased secretion of SST protein
CTD
PMID:17961553
NCBI chr11:90,461,546...90,462,823
Ensembl chr11:76,956,896...76,958,173
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Svep1
sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
increases oxidation
EXP
linsidomine results in increased oxidation of SVEP1 protein
CTD
PMID:28086193
NCBI chr 5:72,811,200...72,988,185
Ensembl chr 5:72,811,410...72,988,525
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Synrg
synergin, gamma
increases oxidation
EXP
linsidomine results in increased oxidation of SYNRG protein
CTD
PMID:28086193
NCBI chr10:69,346,154...69,428,714
Ensembl chr10:68,849,642...68,931,250
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Sytl4
synaptotagmin-like 4
increases oxidation
EXP
linsidomine results in increased oxidation of SYTL4 protein
CTD
PMID:28086193
NCBI chr X:101,428,785...101,479,207
Ensembl chr X:97,135,500...97,185,854
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Tgfb1
transforming growth factor, beta 1
multiple interactions decreases expression increases activity
EXP
2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide inhibits the reaction [linsidomine results in decreased expression of TGFB1 mRNA]; 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide inhibits the reaction [linsidomine results in decreased expression of TGFB1 protein] linsidomine results in decreased expression of TGFB1 mRNA; linsidomine results in decreased expression of TGFB1 protein linsidomine results in increased activity of TGFB1 protein
CTD
PMID:11994256
NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
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Tlr4
toll-like receptor 4
multiple interactions
ISO
TLR4 gene mutant form inhibits the reaction [linsidomine results in increased secretion of IL6 protein]; TLR4 gene mutant form inhibits the reaction [linsidomine results in increased secretion of TNF protein]
CTD
PMID:29175419
NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628
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Tnf
tumor necrosis factor
increases secretion multiple interactions
ISO
linsidomine results in increased secretion of TNF protein TLR4 gene mutant form inhibits the reaction [linsidomine results in increased secretion of TNF protein]
CTD
PMID:29175419
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
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Trim40
tripartite motif-containing 40
increases oxidation
EXP
linsidomine results in increased oxidation of TRIM40 protein
CTD
PMID:28086193
NCBI chr20:1,680,554...1,691,123
Ensembl chr20:1,676,270...1,685,214
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Trpm1
transient receptor potential cation channel, subfamily M, member 1
increases oxidation
EXP
linsidomine results in increased oxidation of TRPM1 protein
CTD
PMID:28086193
NCBI chr 1:117,718,896...117,835,434
Ensembl chr 1:117,718,896...117,834,605
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Trpm7
transient receptor potential cation channel, subfamily M, member 7
increases oxidation
EXP
linsidomine results in increased oxidation of TRPM7 protein
CTD
PMID:28086193
NCBI chr 3:134,499,617...134,588,113
Ensembl chr 3:114,046,258...114,135,190
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Unc13a
unc-13 homolog A
increases oxidation
EXP
linsidomine results in increased oxidation of UNC13A protein
CTD
PMID:28086193
NCBI chr16:18,367,891...18,415,808
Ensembl chr16:18,336,229...18,381,872
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Vgf
VGF nerve growth factor inducible
increases oxidation
EXP
linsidomine results in increased oxidation of VGF protein
CTD
PMID:28086193
NCBI chr12:25,274,004...25,281,803
Ensembl chr12:19,637,320...19,640,341
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Vim
vimentin
increases oxidation
EXP
linsidomine results in increased oxidation of VIM protein
CTD
PMID:28086193
NCBI chr17:81,577,261...81,585,746
Ensembl chr17:76,668,647...76,677,187
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Wdr7
WD repeat domain 7
increases oxidation
EXP
linsidomine results in increased oxidation of WDR7 protein
CTD
PMID:28086193
NCBI chr18:57,165,482...57,448,568
Ensembl chr18:57,165,488...57,448,540
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Whrn
whirlin
increases oxidation
EXP
linsidomine results in increased oxidation of WHRN protein
CTD
PMID:28086193
NCBI chr 5:81,843,820...81,933,400
Ensembl chr 5:76,828,301...76,912,223
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Ythdc1
YTH N6-methyladenosine RNA binding protein C1
increases oxidation
EXP
linsidomine results in increased oxidation of YTHDC1 protein
CTD
PMID:28086193
NCBI chr14:21,540,276...21,570,724
Ensembl chr14:21,185,440...21,216,028
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Zfp148
zinc finger protein 148
increases oxidation
EXP
linsidomine results in increased oxidation of ZFP148 protein
CTD
PMID:28086193
NCBI chr11:80,780,865...80,890,877
Ensembl chr11:67,281,707...67,385,772
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Zfp518a
zinc finger protein 518A
increases oxidation
EXP
linsidomine results in increased oxidation of ZFP518A protein
CTD
PMID:28086193
NCBI chr 1:249,668,815...249,694,401
Ensembl chr 1:239,719,505...239,744,979
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