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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:lercanidipine
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Accession:CHEBI:135930 term browser browse the term
Synonyms:related_synonym: Formula=C36H41N3O6;   InChI=1S/C36H41N3O6/c1-24-31(34(40)44-6)33(28-18-13-19-29(22-28)39(42)43)32(25(2)37-24)35(41)45-36(3,4)23-38(5)21-20-30(26-14-9-7-10-15-26)27-16-11-8-12-17-27/h7-19,22,30,33,37H,20-21,23H2,1-6H3;   InChIKey=ZDXUKAKRHYTAKV-UHFFFAOYSA-N;   SMILES=C1(C(=C(NC(=C1C(=O)OC(C)(C)CN(C)CCC(C2=CC=CC=C2)C3=CC=CC=C3)C)C)C(=O)OC)C4=CC=CC(=C4)[N+](=O)[O-];   lercanidipine HCl;   lercanidipine hydrochloride;   masnidipine;   zanidip
 xref: CAS:100427-26-7;   Drug_Central:4157;   HMDB:HMDB0014669
 xref_mesh: MESH:C060343


show annotations for term's descendants           Sort by:
lercanidipine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor decreases activity ISO lercanidipine results in decreased activity of AR protein CTD PMID:25257666 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Esr1 estrogen receptor 1 decreases activity ISO lercanidipine results in decreased activity of ESR1 protein CTD PMID:25257666 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Ins2 insulin 2 decreases expression ISO lercanidipine results in decreased expression of INS protein CTD PMID:17220028 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases activity
multiple interactions		 EXP
ISO		 lercanidipine results in decreased activity of MAPK1 protein
lercanidipine inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK1 protein]		 CTD PMID:18973813 PMID:33771646 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases activity
multiple interactions		 EXP
ISO		 lercanidipine results in decreased activity of MAPK3 protein
lercanidipine inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK3 protein]		 CTD PMID:18973813 PMID:33771646 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 decreases activity
multiple interactions		 ISO lercanidipine results in decreased activity of NR1H4 protein
lercanidipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]		 CTD PMID:25257666 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta decreases phosphorylation EXP lercanidipine results in decreased phosphorylation of PDGFRB protein CTD PMID:18973813 NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    chemical entity 19909
      group 19863
        polyatomic entity 19862
          molecule 19752
            cyclic compound 19523
              organic cyclic compound 19526
                organic aromatic compound 19390
                  diarylmethane 9440
                    lercanidipine 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    p-block element atom 19849
                      p-block molecular entity 19826
                        carbon group molecular entity 19766
                          organic molecular entity 19785
                            organic molecule 19737
                              organic cyclic compound 19526
                                organic aromatic compound 19390
                                  diarylmethane 9440
                                    lercanidipine 7
paths to the root