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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:manidipine
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Accession:CHEBI:135849 term browser browse the term
Synonyms:related_synonym: Formula=C35H38N4O6;   InChI=1S/C35H38N4O6/c1-24-30(34(40)44-3)32(28-15-10-16-29(23-28)39(42)43)31(25(2)36-24)35(41)45-22-21-37-17-19-38(20-18-37)33(26-11-6-4-7-12-26)27-13-8-5-9-14-27/h4-16,23,32-33,36H,17-22H2,1-3H3;   InChIKey=ANEBWFXPVPTEET-UHFFFAOYSA-N;   SMILES=C(OCCN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=CC=C3)(=O)C=4C(C(C(OC)=O)=C(NC4C)C)C5=CC([N+](=O)[O-])=CC=C5;   franidipine;   manidipine HCl;   manidipine dihydrochloride;   manidipine hydrochloride
 xref: CAS:89226-50-6;   Drug_Central:1631
 xref_mesh: MESH:C054218


show annotations for term's descendants           Sort by:
manidipine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO manidipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] CTD PMID:11895100 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Ace angiotensin I converting enzyme decreases expression EXP manidipine results in decreased expression of ACE mRNA CTD PMID:16392774 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Ar androgen receptor decreases activity ISO manidipine results in decreased activity of AR protein CTD PMID:25257666 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression EXP manidipine results in decreased expression of CCL2 mRNA CTD PMID:16392774 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP manidipine inhibits the reaction [Isoproterenol results in increased expression of COL1A1 mRNA] CTD PMID:9559417 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions EXP manidipine inhibits the reaction [Isoproterenol results in increased expression of COL3A1 mRNA] CTD PMID:9559417 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Cyba cytochrome b-245 alpha chain decreases expression
multiple interactions		 ISO manidipine results in decreased expression of CYBA mRNA
[sodium arsenite co-treated with manidipine] results in decreased expression of CYBA mRNA; [sodium arsenite co-treated with manidipine] results in decreased expression of CYBA protein		 CTD PMID:15085064 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO manidipine results in decreased activity of CYP2D6 protein CTD PMID:10805063 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 decreases activity ISO manidipine results in decreased activity of CYP2J2 protein CTD PMID:30965050 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794 		JBrowse link
G Drd1 dopamine receptor D1 affects binding
multiple interactions		 ISO manidipine binds to DRD1
manidipine inhibits the reaction [SCH 23390 binds to DRD1 protein]		 CTD PMID:8794996 PMID:9533112 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions
affects binding		 ISO manidipine inhibits the reaction [Raclopride binds to DRD2 protein]
manidipine binds to DRD2		 CTD PMID:8794996 PMID:9533112 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Esr1 estrogen receptor 1 decreases activity ISO manidipine results in decreased activity of ESR1 protein CTD PMID:25257666 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 ISO [sodium arsenite co-treated with manidipine] results in increased expression of HMOX1 mRNA; [sodium arsenite co-treated with manidipine] results in increased expression of HMOX1 protein
manidipine results in increased expression of HMOX1 mRNA		 CTD PMID:15085064 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO manidipine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Nos3 nitric oxide synthase 3 increases expression EXP manidipine results in increased expression of NOS3 mRNA; manidipine results in increased expression of NOS3 protein CTD PMID:16392774 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nox4 NADPH oxidase 4 decreases expression EXP manidipine results in decreased expression of NOX4 mRNA CTD PMID:16392774 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406 		JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP manidipine inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA] CTD PMID:9559417 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
increases activity		 ISO manidipine inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; manidipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]
manidipine results in increased activity of NR1H4 protein		 CTD PMID:25257666 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases activity ISO manidipine results in decreased activity of PPARG protein CTD PMID:25257666 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression EXP manidipine results in decreased expression of VCAM1 mRNA CTD PMID:16392774 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vdr vitamin D receptor increases activity ISO manidipine results in increased activity of VDR protein CTD PMID:25257666 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19922
    chemical entity 19920
      group 19878
        polyatomic entity 19877
          molecule 19770
            cyclic compound 19535
              organic cyclic compound 19545
                organic aromatic compound 19380
                  diarylmethane 9457
                    manidipine 21
Path 2
Term Annotations click to browse term
  CHEBI ontology 19922
    subatomic particle 19892
      composite particle 19892
        hadron 19920
          baryon 19892
            nucleon 19920
              atomic nucleus 19892
                atom 19892
                  main group element atom 19866
                    p-block element atom 19866
                      p-block molecular entity 19866
                        carbon group molecular entity 19805
                          organic molecular entity 19775
                            organic molecule 19755
                              organic cyclic compound 19545
                                organic aromatic compound 19380
                                  diarylmethane 9457
                                    manidipine 21
paths to the root