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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:camostat
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Accession:CHEBI:135632 term browser browse the term
Definition:A benzoate ester resulting from the formal condensation of the carboxy group of 4-guanidinobenzoic acid with the hydroxy group of 2-(dimethylamino)-2-oxoethyl (4-hydroxyphenyl)acetate. It is a potent inhibitor of the human transmembrane protease serine 2 (TMPRSS2) and its mesylate salt is currently under investigation for its effectiveness in COVID-19 patients.
Synonyms:exact_synonym: 4-{2-[2-(dimethylamino)-2-oxoethoxy]-2-oxoethyl}phenyl 4-carbamimidamidobenzoate
 related_synonym: 4-{2-[(dimethylcarbamoyl)methoxy]-2-oxoethyl}phenyl 4-carbamimidamidobenzoate;   Formula=C20H22N4O5;   InChI=1S/C20H22N4O5/c1-24(2)17(25)12-28-18(26)11-13-3-9-16(10-4-13)29-19(27)14-5-7-15(8-6-14)23-20(21)22/h3-10H,11-12H2,1-2H3,(H4,21,22,23);   InChIKey=XASIMHXSUQUHLV-UHFFFAOYSA-N;   N,N-dimethylcarbamoylmethyl 4-(4-guanidinobenzoyloxy)phenylacetate;   SMILES=CN(C)C(=O)COC(=O)CC1=CC=C(OC(=O)C2=CC=C(NC(N)=N)C=C2)C=C1;   camostatum
 xref: CAS:59721-28-7;   Chemspider:2440;   DrugBank:DB13729;   Drug_Central:471;   KEGG:D07606
 xref_mesh: MESH:C034532
 xref: PMCID:PMC7809394;   PMID:23412700;   PMID:26166259;   PMID:26887332;   PMID:33176395;   PMID:33225308;   PMID:33505639;   PMID:33564221;   PMID:33676899;   PMID:7341342;   Wikipedia:Camostat
 cyclic_relationship: is_conjugate_base_of CHEBI:169939


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camostat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cckar cholecystokinin A receptor increases expression EXP camostat results in increased expression of CCKAR mRNA CTD PMID:10458643 NCBI chr14:61,505,270...61,513,618
Ensembl chr14:61,505,270...61,513,618 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP camostat inhibits the reaction [PLG protein modified form results in increased expression of CCL2 mRNA] CTD PMID:27773435 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions EXP camostat inhibits the reaction [Adenine results in increased expression of CCN2 mRNA]; camostat inhibits the reaction [PLG protein modified form results in increased expression of CCN2 mRNA] CTD PMID:25766432 PMID:27773435 NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:22,621,501...22,624,976 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression 		ISO mirdametinib inhibits the reaction [camostat results in increased expression of CCND1 protein] CTD PMID:25104499 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Ccnd3 cyclin D3 multiple interactions
increases expression 		ISO mirdametinib inhibits the reaction [camostat results in increased expression of CCND3 protein] CTD PMID:25104499 NCBI chr 9:20,891,696...20,987,199
Ensembl chr 9:20,891,704...20,987,033 		JBrowse link
G Ccne1 cyclin E1 increases expression
multiple interactions 		ISO camostat results in increased expression of CCNE1 protein
mirdametinib inhibits the reaction [camostat results in increased expression of CCNE1 protein] 		CTD PMID:25104499 NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:99,918,674...99,927,822 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP camostat inhibits the reaction [Adenine results in increased expression of COL1A1 mRNA] CTD PMID:25766432 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460 		JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions EXP camostat inhibits the reaction [Adenine results in increased expression of COL3A1 mRNA] CTD PMID:25766432 NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:54,866,632...54,903,232 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions EXP camostat inhibits the reaction [Adenine results in increased expression of CYBB mRNA] CTD PMID:25766432 NCBI chr  X:16,030,596...16,065,065
Ensembl chr  X:16,030,596...16,065,065 		JBrowse link
G Egr1 early growth response 1 multiple interactions
increases expression 		ISO mirdametinib inhibits the reaction [camostat results in increased expression of EGR1 mRNA] CTD PMID:25104499 NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843 		JBrowse link
G Fgf21 fibroblast growth factor 21 multiple interactions ISO camostat results in increased expression of and results in increased secretion of FGF21 protein CTD PMID:30920846 NCBI chr 1:105,219,825...105,221,376
Ensembl chr 1:105,219,825...105,232,056 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression 		ISO mirdametinib inhibits the reaction [camostat results in increased expression of FOS mRNA] CTD PMID:25104499 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598 		JBrowse link
G Ier3 immediate early response 3 increases expression ISO camostat results in increased expression of IER3 mRNA CTD PMID:25104499 NCBI chr20:2,933,173...2,934,377
Ensembl chr20:2,933,174...2,934,377 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression
increases phosphorylation 		ISO camostat results in increased expression of JUN mRNA
camostat results in increased phosphorylation of JUN protein 		CTD PMID:25104499 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression ISO camostat results in increased expression of JUNB mRNA CTD PMID:25104499 NCBI chr19:40,081,126...40,082,910
Ensembl chr19:40,073,541...40,085,218 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation 		ISO mirdametinib inhibits the reaction [camostat results in increased phosphorylation of MAPK1 protein]; trametinib inhibits the reaction [camostat results in increased phosphorylation of MAPK1 protein] CTD PMID:25104499 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions 		ISO camostat results in increased phosphorylation of MAPK3 protein
mirdametinib inhibits the reaction [camostat results in increased phosphorylation of MAPK3 protein]; trametinib inhibits the reaction [camostat results in increased phosphorylation of MAPK3 protein] 		CTD PMID:25104499 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mki67 marker of proliferation Ki-67 increases expression
multiple interactions 		ISO camostat results in increased expression of MKI67 protein
mirdametinib inhibits the reaction [camostat results in increased expression of MKI67 protein] 		CTD PMID:25104499 NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593 		JBrowse link
G Nos3 nitric oxide synthase 3 increases expression EXP camostat results in increased expression of NOS3 mRNA CTD PMID:10458643 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664 		JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions EXP camostat inhibits the reaction [Adenine results in increased expression of NOX1 mRNA] CTD PMID:25766432 NCBI chr  X:101,572,338...101,625,571
Ensembl chr  X:101,572,340...101,595,520 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions
increases expression 		ISO mirdametinib inhibits the reaction [camostat results in increased expression of PCNA protein] CTD PMID:25104499 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901 		JBrowse link
G Plg plasminogen decreases activity
multiple interactions 		EXP camostat results in decreased activity of PLG protein modified form
camostat inhibits the reaction [PLG protein modified form results in increased expression of CCL2 mRNA]; camostat inhibits the reaction [PLG protein modified form results in increased expression of CCN2 mRNA]; camostat inhibits the reaction [PLG protein modified form results in increased expression of TGFB1 mRNA]; camostat inhibits the reaction [PLG protein modified form results in increased expression of TNF mRNA] 		CTD PMID:27773435 NCBI chr 1:50,872,927...50,915,406
Ensembl chr 1:50,872,926...50,917,320 		JBrowse link
G Rps6 ribosomal protein S6 increases phosphorylation ISO camostat results in increased phosphorylation of RPS6 protein CTD PMID:25104499 NCBI chr 5:106,417,680...106,420,540
Ensembl chr 5:106,417,680...106,420,566 		JBrowse link
G Serpine1 serpin family E member 1 multiple interactions EXP camostat inhibits the reaction [Adenine results in increased expression of SERPINE1 mRNA] CTD PMID:25766432 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357 		JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO camostat inhibits the reaction [Bleomycin results in increased phosphorylation of SMAD2 protein] CTD PMID:26599507 NCBI chr18:72,124,792...72,193,345
Ensembl chr18:72,124,863...72,187,388 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases phosphorylation ISO camostat results in increased phosphorylation of STAT3 protein CTD PMID:25104499 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO
EXP 		camostat inhibits the reaction [Bleomycin results in increased expression of TGFB1 mRNA]
camostat inhibits the reaction [Adenine results in increased expression of TGFB1 mRNA]; camostat inhibits the reaction [PLG protein modified form results in increased expression of TGFB1 mRNA] 		CTD PMID:25766432 PMID:26599507 PMID:27773435 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP 		camostat inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
camostat inhibits the reaction [PLG protein modified form results in increased expression of TNF mRNA] 		CTD PMID:20023007 PMID:27773435 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      application 20621
        anti-inflammatory agent 16834
          camostat 28
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            heteroorganic entity 20219
                              organochalcogen compound 19904
                                organooxygen compound 19806
                                  carbon oxoacid 19155
                                    carboxylic acid 19152
                                      carboacyl group 18085
                                        univalent carboacyl group 18085
                                          carbamoyl group 17921
                                            carboxamide 17921
                                              tertiary carboxamide 877
                                                camostat 28
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